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    • 专利摘要:

    公开号:SU812176A3
    申请号:SU772456704
    申请日:1977-02-28
    公开日:1981-03-07
    发明作者:А.Якобаччи Джуллермо；Дж.Свини Джеймс
    申请人:Дзе Кока-Кола Компани (Фирма)；
    IPC主号:
    专利说明:

    the form. After drying by evaporation of the SCHE, the light same 3 oil is obtained. This oil is dissolved in 25 ml of acetic anhydride and 30 ml of pyridine, and the solution is held at RT at overnight. It is then injected into 200 ml of ice in dyes and extracted with 150 ml of LCHS. The LCHS5 layer is washed with 200 ml of ice water, 200 ml of cold 3% NSC and 200 ml of cold 0.5% NaHCO. After incubation and evaporation of CHC jCHOBa get a pale yellow oil. The latter was divided into two components by chromatography using a 2.5 x 40 cm column, filled with S) LICARCC-7, and using a 50% CHCEi - hexane mixture as eluent. The fractions containing the component with a higher R coefficient are combined and crystallized from methane, as a result of which 2.77 g (57% yield, two extracts) of 4,5,7, -triacetoxyflavane, m.p. 102-103c. Found,%: C 65.78 / H 5.09 ui Calculated,%: C 65.63, H 5.20. Mass spectrum: m / e (true ratio) 348 (18), 342 (18), 300 (19 258 (25), 120 (38), 69. (21), 43 (10 NMR spectrum: 1.7 -2.1 (2H, SZ-N, t), 2.20 (3N, OAc, S). 2.24 (6H, RLV, 5), 2.5-2.7 (2H, C4-H, t), 4.97 (1H, C2-H, q 6.50 (2H, C6 and C8-H, q), 7.20 (4H, C2 ff J f. H f P I, 6 "-H, q). IR spectrum, µm (EHF): 5.65, 8.22, 8.89, 9.24, 9.40, 9.79., Example 2. 4 -Methoxy-3, 5, -triacetoxyflavane ... ... To a solution of 5.0 g of triacetylcespira in 250 ml of tetrahydrofuran-ethanol, 500 mg of HBH is added. After stirring at room temperature, an additional 500 mg of NaBH is added for 30 minutes and stirring is continued in about difficulty for 1 h. This solution is mown with 750 ml. cold 0.5% acetic acid and extracted three times with 250 ml. After drying (N3,504) and evaporation of the CNSC a light brown oil is obtained. This oil is dissolved in 25 ml of acetic anhydride and 30 ml of pyridine and kept at room temperature at room temperature overnight. The solution is then added to 200 ml of ice-cold water and extracted with 150 ml of CHC & A layer of CHCCj is treated with 200 ml of ice-cold water, 200 with cold 3% ISK and 200 ml with cold 0.5% NaHCOj. After drying and evaporation of the CHse, a pale yellow oil is obtained. This oil was separated by chromatography on a 2.5 x X 40 cm column filled with CC-7, using as mixture eluent; ,, ,, .., -.: 4: j.,;:. I., :) ,. HOFIE y -; i-: K; i iS:.; ./, ii; o3 SI hexane with SNS, in the ratio,.,.; 50:50 The fractions containing the component with a higher Rf coefficient are combined and maintained at 20 at 5 ° C overnight. The resulting white solid is removed by filtration and dried in vacuo to give 2.12 g (yield 44%) of 4-methoxy-3, 5,7-triacet. Oxyflavane, m.p. 106-107 s. Found,%: C 63.70, H 5.15 C 27. IT. 8 Calculated,%: C 63.77 / H 5.31 / Mass spectrum: m / e (true ratio): 372 (100), 150 (85), 330 (48), 43 (49), 414 (45 ), 238 (40), 287 (39). NMR spectrum, (5 (CDCe,): 2.0-2.4 (2H, C3-H, m), 2.6-3.0 (2H, C4-H, m), 2.32 (3H , OAc, S), 2.38 (3N, OAc, S), 2.38 (3H, OAc, S), 4.00 (3H, OCHj, S),: iH, C2-H / q), 6 , 85 (2H, 5, 10 6.85 (2H, 06 and 7.2-7, G (3H, C2; 5, b-H, t). C8-H, q), IR spectrum, μm ( KVH); 8.26 / 8.86, 5.63; 9.77; 7.27; 82.9; 41. H, 4,5,7-Tetra Example 3, acetoxy flavan. To a mixed solution of 1.0 g 3, 4, 5, 7-tetraacetoxyflavanone and 50 ml of a 50% aqueous solution of tetrahydrofuran in ethanol are added 100 mg of NaBH4. After 30 minutes, an additional 100 mg of NaBH is added and the stirring is continued at room temperature for a total of 1 hour. the mixture is added to 200 ml of cold 0.5% acetic acid and three times extra 75 ml. The combined CHS extracts are dried () and evaporated to give a thick oil. 6 ml of acetic anhydride and 80 ml of pyridine are added to this oil and the resulting solution is kept at room temperature overnight. ml of ice water, the resulting emulsion was extracted with 125 ml of chloroform, and their chloroform phase was washed with 100 ml of ice water, 100 ml of cold 3% HCE and 100 ml of 0.5% NaHCO. After drying (.) And evaporation of CHC1, an oil is obtained which is purified by chromatography on a 2.5 x 4.0 cm column filled with SDL3CARCC-7. The first substance, which is eluted with a mixture of 60% CH 2 H 2 -hexane, is 3, 4, 5,7-tetraacetoxy flavan. The latter, after recrystallization from methanol, is obtained in an amount of 345 mg (yield: 36%), mp. 143144 ° C. Found,%: C 62.44; H 5.01 Calculated,%: C 62.44, H 4.98. Mass spectrum: m / e (true ratio) 442 (29), 400 (52), 358 (100)
    316 (85), 274 (46), 139 (48), 136 (62), 43 (84) ..
    NMR spectrum, J- (COCfjj: 2.1 (2H, C3-H, bm), 2.30 (12H, 9Ls, 5), 2.6 (2H, C4-H, m). 5.0 ( lH, Cl-H, q), 6.58 (2H, 06 and C8-H, q), 7.3 (3H, C2.5, 6-H, m).
    IR (DR) micron (EHF): 2.88, 5.63 / 7.27 / 8.22 / 8.88, 9.25 / 9.80.
    characterized in that. which is a flavanone derivative of the general formula
    权利要求:
    Claims (1)
    [1]
    (11) Claims of the invention A process for the preparation of flvane derivatives of the general formula: where R and R2 are acetoxy; R is a hydrogen atom or acexy group; R is methox- or acetoxy. Rs have the above R.E.R.R., and are now being subjected to the reduction of the borohydride with the RIDOM alkaline metal in an organic solvent medium, followed by treatment with acetic acid and then acetic anhydride in the presence of pyridine. / -Information sources. taken into account in the examination of I. Bell K.N. Sodium borohydride by-side-chain oxygen chain fromphenolic ketones - Aust. J. Chem, 1969, 22, c. 601
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    同族专利:
    公开号 | 公开日
    FR2342968B1|1984-02-10|
    US4105675A|1978-08-08|
    FR2342968A1|1977-09-30|
    AU2228277A|1978-08-24|
    JPS52110728A|1977-09-17|
    GB1552402A|1979-09-12|
    DE2708845A1|1977-09-08|
    AU512171B2|1980-09-25|
    IT1091564B|1985-07-06|
    GB1552403A|1979-09-12|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3266903A|1963-01-25|1966-08-16|Jurd Leonard|Methods of using flavylium compounds for food coloring|EP0019524A1|1979-05-09|1980-11-26|Societe De Recherches Industrielles Sori|Process for preparing flavilium derivatives, products obtained by the processus and their therapeutical application|
    HU219914B|1992-09-21|2001-09-28|BIOGAL Gyógyszergyár Rt.|Process for producing a flavylium derivatives and pharmaceutical compositions containing them|
    US5683678A|1995-03-09|1997-11-04|The Procter & Gamble Company|Oral compositions|
    US6180154B1|1999-04-28|2001-01-30|The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University|Natural colorant from potato extract|
    US8124143B2|2007-06-21|2012-02-28|Suntava, Llc|Anthocyanin pigment/dye compositions through corn extraction|
    JP5247085B2|2007-08-07|2013-07-24|三井農林株式会社|Method for producing 3-deoxyanthocyanidins|
    FR3036620B1|2015-05-27|2017-09-01|Inst Biophytis|USE OF 3-DEOXYANTHOCYANIDINES FOR THE TREATMENT OF OCULAR DISEASES|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/662,742|US4105675A|1976-03-01|1976-03-01|Method for making 3-deoxyanthocyanidins|
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