• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The novel 1,4-benzodiazepines of the formula Ia or Ib which are shown in the description can be prepared by customary methods and are suitable as active substances for medicaments.
    公开号:SU1681729A3
    申请号:SU874202929
    申请日:1987-07-20
    公开日:1991-09-30
    发明作者:Вальтер Герхард；Харреус Альбрехт；Вебер Карл-Гейнц；Странски Вернер；Муацевич Гойко；Казальс-Штенцель Иорге；Бехтель Вольф-Дитрих
    申请人:Берингер Ингельгейм Кг (Фирма)；
    IPC主号:
    专利说明:

    Table 3
    权利要求:
    Claims (1)
    [1]
    Formula and Method for the preparation of 1,4-benzodiazepine derivatives of the general formula (la) or where A is a group of CH or N:
    R is a group —O — X — CO — OR3. — O — X — CO — OR4, —O — J — R5, or —0 — X / Hl) 35 where R3 is a Ci — Sb — al kil;
    R4 is the group —NRsRt, where Re and Rz are independently hydrogen, CiCe alkyl, and if R6 is hydrogen, then. 40 Rz is the group / N-Re, where Re is a C1-Cd alkip, or the group ~ - {CH2) 2b / p:
    Rs are groups wherein Rg and Rio are the same and mean Cs-Cb alkyl;
    X is Ci-Ce alkylene;
    Y - Cr-Ce-alkylene:
    Ri is St-C4 alkyl;
    R 2 ~ phenyl unsubstituted or singly substituted by halogen, characterized in that the compound of formula II wherein A, Ri and R 2 have the indicated meanings, are reacted with a compound of formula III
    Hal - R11 where Hal is a halogen;
    R11 is the group —X — CO — OR3, —X — CO — R4, —J — RsnnH — X—, where K3, R4. Rs, X and Y have the indicated meanings, or with its hydrochloride in an inert organic solvent in the presence of a base at the boiling point of the reaction mixture, followed by, if necessary, reduction of the target product (la) to compound (16).
    Table 1
    Compounds of formula (1a) Example A R Ri R2 T.pl 1 CH -O-CH 2 -CH 2 -NQO SNZ SbN5 4 A/ -O-SNG-S " FROMZ 0[1 SNZ SW 51'-7 V -O- (CH2) s <o SNZ CeH5 187-188 ° P0
    table 2
    Table 3
    CompoundMr. A R a b N N -O * (CH 2 ) 3 - coax 2 n 5 0-CH Z -COONH-L- Cit H 9 in N o-ch 2 -coonh- <3n-ch 3 g N 0 “CH 2 -CM 2 -a / ' D N with e N N - z CH 3 о-sn 2 - ^ Г СНз well N 0-CH 2 - C00NH- (CHg) 2 -Nf } 3 N -O-CH 2 -COON (C2H5) 2
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    同族专利:
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    EP0255028A2|1988-02-03|
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    引用文献:
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    GB1332766A|1971-06-18|1973-10-03|Upjohn Co|Triazolo-benzodiazepines|
    FR2183716B1|1972-05-05|1976-12-03|Centre Etd Ind Pharma|
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    US4663321A|1984-06-26|1987-05-05|Merck & Co., Inc.|Triazolobenzodiazepines and pharmaceutical use|
    DE3610848A1|1986-04-01|1987-10-15|Boehringer Ingelheim Kg|NEW 1,4-DIAZEPINE|
    US4735941A|1986-12-23|1988-04-05|Merck & Co., Inc.|1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents|GB8720414D0|1987-08-28|1987-10-07|Roussel Lab Ltd|Chemical compounds|
    US5895785A|1987-10-20|1999-04-20|Ruth Korth|Treatment and prevention of disorders mediated by LA-paf or endothelial cells|
    DE3808283A1|1988-03-12|1989-09-21|Boehringer Ingelheim Kg|NEW 3,4,5-SUBSTITUTED 4H-1,2,4-TRIAZOLE, THEIR PREPARATION AND USE|
    DE3810848A1|1988-03-30|1989-10-19|Boehringer Ingelheim Kg|NEW 2,3,4-SUBSTITUTED IMIDAZOLE AND 3,4,5-SUBSTITUTED 1,2,4-TRIAZOLE, THEIR PREPARATION AND USE|
    IL91386D0|1988-08-24|1990-04-29|Boehringer Ingelheim Kg|Method for treating autoimmune diseases by using a paf antagonist and pharmaceutical compositions comprising it|
    GR900100619A|1989-08-19|1991-12-30|Boehringer Ingelheim Kg|Substituted n-heterocyclic preparation process and use thereof|
    JP2733708B2|1990-09-22|1998-03-30|カースル産業株式会社|Exhaust port filter device|
    JP2520577Y2|1991-05-28|1996-12-18|住友重機械工業株式会社|Slaked lime dissolution injection device|
    ES2181665T3|1991-11-04|2003-03-01|Ruth-Maria Korth|TREATMENT AND PREVENTION OF MENTAL DISEASES, ACCOMPANIED BY ELEVATED LEVELS OF LISO PAF, WITH PAF ANTAGONISTS.|
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    JP3719324B2|1997-12-24|2005-11-24|豊田工機株式会社|Machining method using cold air cooling|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE3625197|1986-07-25|
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