Method of producing dispersion

专利摘要:
This invention relates to the chemical and pharmaceutical industry. The goal is to increase stability. To the teens or piroxicam mixed with soluble skimmed milk powder at 70-85 C.
公开号:SU1621804A3
申请号:SU864027147
申请日:1986-03-19
公开日:1991-01-15
发明作者:Хирсбруннер Пьер
申请人:Сосьете Де Продюи Нестле С.А. (Фирма)；
IPC主号:

专利说明:

This invention relates to the chemical pharmaceutical industry and relates to a process for the preparation of a composition.
The chain of the invention is to increase the stable ip, 7 and: o p 1 3 g of tenoxicam is treated with 27 g of soluble nonfat dry milk. After 90 seconds of treatment, the temperature is measured at 85 ° C and a very homogeneous and fine powder is obtained. By mixing 4 g of this powder in a dry state with 96 g of decapital soluble dry milk, a granular composition is obtained - creamy-colored, containing 20 g of tenoxicam per dose of 5 g (therapeutic dose) with excellent suspension stability during dispersion of the composition in water. The bitterness caused by the strong dispersion of the bitter active principle can be reduced by using aspartame (25 mg / cose), a flavoring agent (vanillin, 10 mg / cesa) and about 1% of a formative agent (Hercules Powders carboxymethylcellulose).
In the untreated standard (control), tenoxicam sedimented at 45% after 15 minutes, at 95% after 30 minutes after suspension in water.
Example 2. 8 g of pyroxicism (particle size 0.2-4 microns) are introduced into a glass reactor containing 92 g of skimmed instant milk powder. After gentle processing with stirring using a magnetic stirrer for 20 minutes (analogously to example 2) in a water bath with a temperature of 70 ° C, a highly colored granulated mixture is obtained, which, after diluting it with a dry mixture of 600 g of non-fat soluble dry milk and 300 g of casein condensed with formol (product of the brand PLASVita Dynamit-No-;
yo
at
oo
about
bel), tablets are molded by conventional methods, a tablet weighing 2.5 g containing 20 g of finely dispersed active principle.
Putting it in contact with water allows one to obtain a quick dispersion and the colored active principle does not sediment after even a long time. Use a sweetening agent and flavoring agent, as in example 2.
In all of these examples, the water content in skimmed instant milk powder is 3S5%.
The positive effect of the proposed method is to increase
the stability of the resulting dispersion, since the powder obtained is well suited for rochat

权利要求:
Claims (1)
[1]
Invention Formula
The method of obtaining a dispersion by mixing the active and auxiliary substances, which distinguishes - with the aim of increasing stability, is used as the active substance tenoxicas, or piroxicam in an amount of 0, - 10 wt.% And the auxiliary substances are both: - dried MOJICKO, while the components are mixed at 70-85 ° C.

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法律状态:

优先权:

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申请号 | 申请日 | 专利标题

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CH1235/85A|CH663899A5|1985-03-20|1985-03-20|PROCESS FOR THE PREPARATION OF A COMPOSITION BASED ON A FINELY DIVIDED LOW HYDROSOLUBILITY ACTIVE INGREDIENT.|

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