• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    1. Process for preparing a solution of alkali metal methioninate free from inorganic salts, which solution can be directly used as an additive for feeding livestock, characterized in that a sufficient amount of 4-methylmercapto-2-aminobutyramide is hydrolysed by means of an alkali metal hydroxide, the ammonia formed is removed and a solution of alkali metal methioninate, the concentration of which, expressed in equivalents of methionine, is between 30 and 60% by weight, is obtained, where appropriate after concentration.
    公开号:SU1598867A3
    申请号:SU864028573
    申请日:1986-12-02
    公开日:1990-10-07
    发明作者:Жиллоннье Клод；Муассон Рене
    申请人:Рон-Пуленк Нютрисьон Анималь (Фирма)；
    IPC主号:
    专利说明:

    (21) (22) (31) (32) (33) (46) (71) (7.2)
    4028573 / 23-04
    02.12.86
    8517847
    12/03/85
    FR
    07.10.90.
    Bul Number 37
    Ron-Poulenc Nutrizion Animal (FR) Claude Gillonnier and Rene Moisson (FR)
    (53) 547.466.07 (088.8) (56) Patent of France; 2499563, cl. C 07 C 149/247, 1983.
    Patent of France No. 2499565, cl. C 07 C 149/247, 1983.
    Laid out in France for registration number 2372797, cl. C 07 C 99/10, J978.
    (54) METHOD FOR PREPARING 30-60% -NOTE SODIUM METHININATE SOLUTION
    (57) The invention relates to the production of animal feed, in particular the production of an additive thereto, a 30-60% sodium methioninate solution. The goal is to improve the quality of the target product. For this, acetone is removed from the reaction mixture obtained by catalytic hydrolysis of 4-methylmercapto-2-aminobutyronitrile in the presence of acetone and NaOH. Next, o-amino amide is hydrolyzed with an aqueous solution of NaOH containing 0.9-1.1 mol of NaOH on 1 mole of amide, with removal of ammonia formed. The resulting solution contains a very small amount of impurities, which allows it to be used directly for feeding animals.
    This invention relates to an improved process for the preparation of an aqueous solution of sodium methioninate used as an additive to animal feed.
    The aim of the invention is to improve the quality of the target product.
    Example 1. In a reactor with a capacity of 500 cm-, allowing to operate under pressure, 1 mol of 3-methyl-mercapto-propionic aldehyde (MMPA) and 20 mg of triethylamine are introduced.
    1.05 moles of hydrocyanic acid are introduced at a temperature of about 20 ° C. After the reaction has proceeded, 5 moles of liquid are introduced over 10 minutes.
    ammonia. Heated at B for 30 minutes under a pressure of 11.5 bar all the time intensively mixing. Excess ammonia is removed by relieving the pressure. The reaction mixture contains 0.8 mol of residual ammonia per 1 mol of formed aminonitrile. After cooling to a temperature close to 10 ° C, 350 g of aqueous ipacTBOpa containing 0.2 mol of acetone and 0.2 mol of sodium hydroxide are added. The temperature rises to 20-25 ° C. Heated at 30 ° C for 1 hour. Acetone and excess aMMViaK are removed under reduced pressure. 68 g of 50% sodium hydroxide are then added.
    po
    00
    but

    (0.85 mol), then heated at for 5 min. The pressure is reduced to atmospheric, temperature - to 95 C.- After cooling to a temperature close to, 333 g of a yellow solution containing 43.40% by weight of methionine and 0.055% by weight of ammonia are obtained.
    The yield of methionine is 37% relative to the used MMPA.
    The content of residual ammonia can be reduced by concentration under reduced pressure.
    Under these conditions, a solution of the composition is obtained: 43.7% by weight (0.293 mol / 100 g of methionine, 7.08% (0.308 g-atom / 100 g) of sodium, and 0.013% of ammonia. At the same time, the viscosity at 10 cSt density 1,195, point of crystallization.
    Example 2. Into a 500 cm reactor, which allows operation under pressure, 50 g of water, 88.8 g of 4-methyl mercapto-2-amino-butyramide (0.60 mol) and 50.4 g of 50% sodium hydroxide are introduced. liquor (0.63 mol). Complement the mixture by adding water to obtain a 220 g reaction mixture. Heat to 10 minutes, then hold at this temperature for 20 minutes, stirring all the time. Ammonia formed is removed. The temperature is reduced to a value of about. After cooling to a temperature close to 20 seconds, 205 g of a light yellow solution containing 43.2% by weight of methionine is obtained. The yield is close to 99%.
    Example 3. 194.7 g of methylthiopropionic aldehyde and 52.78 g of hydrocyanic acid were added. 120.5 g of ammonia are heated at and added. Heat 30 minutes at bo with.
    0
    ,
    50
    five
    0
    35
    40
    then an aqueous solution containing 292 g of water, 0.2 mol of sodium alcohol and 0.2 mol of acetone is introduced. Heat 30 minutes at. Acetone and ammonium are removed, 68 g of alkali with 50% sodium (0.85 mol) is added and heated at 5 min. This gives 494.5 g of a solution, which is concentrated to obtain 55% by weight of methionine sodium chloride.
    Working in a similar manner, solutions containing 30% by weight and 60% by weight sodium methioninate are obtained.
    The aqueous solution of sodium methioninate obtained in accordance with the inventive method contains impurities in a very small amount, which makes it possible to use this solution directly for feeding animals.
    The sodium methionine solution obtained by a known method contains impurities during the side reaction, which occurs even when acetone is removed during the hydrolysis of the o / -aminoamide.
    权利要求:
    Claims (1)
    [1]
    Invention Formula
    The method of obtaining 30-60% sodium methioninate solution by catalytic hydrolysis of 4-methylmercapito-2-amino-butyronitrile in the presence of acetone and sodium hydroxide to obtain 4-methylmercalito-2-amino-butyramide, which is hydrolyzed with an aqueous solution of caustic soda, containing 0.9-1.1 mol of caustic soda or 1 mol of amide, and ammonia formed is removed, characterized in that, in order to increase the quality of the target product, from the reaction mixture before the hydrolysis of the s-amino-amide is removed acetone.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1598867A3|1990-10-07|Method of producing 30-60% solution of sodium methyoninate
    JP4499706B2|2010-07-07|Method for producing methionine and its salt
    US5672745A|1997-09-30|Method for the continuous preparation of methionine or methionine derivatives
    US2557913A|1951-06-19|Production of methionine
    KR100669873B1|2007-01-17|Method for preparing hydroxymethylthiobutyric acid
    DK147972B|1985-01-21|PROCEDURE FOR PREPARING AN ALFA AMINO ACID AMOID SOLUTION
    US3536726A|1970-10-27|Preparation of alpha-amino-carboxylic acids
    SU503509A3|1976-02-15|Methionine Production Method
    KR940007741B1|1994-08-24|Process for preparing glycine
    RU2017726C1|1994-08-15|Method of imidodiacetonitrile synthesis
    SU1311619A3|1987-05-15|Method for producing methionine
    KR950004048B1|1995-04-22|Process for the preparation of an aqueous solution of the sodium salt of methionine
    US4336384A|1982-06-22|Preparation of 4-amino-3,5,6-trichloropicolinic acid
    SU503510A3|1976-02-15|The method of obtaining d - / - / - 2-amino-2 / -oxyphenyl / acetic acid or its salts
    US3344179A|1967-09-26|Method for synthesizing di-glutamic acid and its alkyl derivatives
    US4560516A|1985-12-24|Process for the production of ethylenediamine tetraacetonitrile
    US2731480A|1956-01-17|Process for the production of epsilon-acyl lysines
    SU536168A1|1976-11-25|The method of obtaining-alkyl-alanines or their salts on the amino group
    SU407887A1|1973-12-10|METHOD OF OBTAINING AMINO ACIDS
    US4014928A|1977-03-29|Process for purifying α-amino acids
    SU755779A1|1980-08-15|Method of preparing 2-semicarbazidoacetic acid
    SU427017A1|1974-05-05|METHOD OF OBTAINING TIADIAZOLYLTIOKARBONATOV
    SU320490A1|METHOD OF OBTAINING 2,2-DIMETHYLETHYLENYMINE
    CS224825B1|1984-01-16|Manufacturing process of 2-mercaptobenzthiazole sodium salt
    SU76318A1|1948-11-30|The method of obtaining formyl ether
    同族专利:
    公开号 | 公开日
    JPS62132853A|1987-06-16|
    FR2590896B1|1988-07-22|
    FR2590896A1|1987-06-05|
    US5147664A|1992-09-15|
    EP0228938A1|1987-07-15|
    ES2008090B3|1989-07-16|
    US4960932A|1990-10-02|
    CA1261348A|1989-09-26|
    KR870005982A|1987-07-08|
    KR940008921B1|1994-09-28|
    AT41148T|1989-03-15|
    DE3662267D1|1989-04-13|
    EP0228938B1|1989-03-08|
    JPH078852B2|1995-02-01|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    FR2372797B1|1976-12-03|1979-03-30|Anvar|
    DE3105009C2|1981-02-12|1994-07-07|Degussa|Use of aqueous sodium or potassium methioninate solutions for supplementation of compound feeds with methionine and method for supplementation|
    DE3105008C2|1981-02-12|1991-04-11|Degussa Ag, 6000 Frankfurt, De|
    EP0067499B1|1981-03-26|1985-10-23|Mitsubishi Gas Chemical Company, Inc.|Process for producing alpha-amino acids|
    FR2565225B1|1984-06-05|1986-10-17|Centre Nat Rech Scient|PROCESS FOR THE CONTINUOUS SYNTHESIS OF AN A-AMINO ACID BY CHEMICAL CATALYTIC HYDROLYSIS AND DEVICE FOR CARRYING OUT THE METHOD|DE4235295A1|1992-10-20|1994-04-21|Degussa|Continuously feasible process for the preparation of methionine or methionine derivatives|
    FR2733231B1|1995-04-24|1997-07-04|Rhone Poulenc Nutrition Animal|PROCESS FOR CONDENSING CYANHYDRIC ACID WITH AN ALDEHYDE|
    JPH09172979A|1995-12-27|1997-07-08|Ajinomoto Co Inc|Feed additive for ruminant containing new compound salt of phosphoric acid and amino acid and antacid|
    FR2785609B1|1998-11-06|2000-12-15|Rhone Poulenc Nutrition Animal|PROCESS FOR THE PREPARATION OF METHIONINE|
    US20110201532A1|2010-02-12|2011-08-18|Jennifer Beth Ponder|Benefit compositions comprising crosslinked polyglycerol esters|
    MX337247B|2011-02-23|2016-02-19|Evonik Degussa Gmbh|Method for producing 2-hydroxy-4-butanenitrile from 3-propanal and hydrogen cyanide.|
    EP2678313B1|2011-02-23|2014-10-15|Evonik Degussa GmbH|Storage-stable 2-hydroxy-4- butyric acid nitrile|
    CN104130169A|2014-07-08|2014-11-05|重庆紫光化工股份有限公司|Environment-friendly clean production method of D,L-methionine|
    EP3199519B1|2014-09-26|2021-02-17|Sumitomo Chemical Company, Limited|Method for producing methionine|
    EP3632894A1|2018-10-01|2020-04-08|Evonik Operations GmbH|Production of methionine from methionine nitrile with low by-product content|
    EP3632895A1|2018-10-01|2020-04-08|Evonik Operations GmbH|Salt-free production of amino acids from their aminonitriles|
    CN111116437B|2018-11-01|2021-02-05|山东新和成氨基酸有限公司|Method and apparatus for producing 2-hydroxy-4-methylthiobutyric acid and intermediate thereof|
    CN112979514A|2019-12-18|2021-06-18|重庆紫光化工股份有限公司|Method for preparing D, L-methionine from 2-hydroxy-4-methylthiobutyronitrile|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR8517847A|FR2590896B1|1985-12-03|1985-12-03|PROCESS FOR THE PREPARATION OF AN AQUEOUS SOLUTION OF AN ALKALINE SALT OF METHIONINE|
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