• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Preparation of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine in a liquid phase halogen exchange reaction from 2,3-dichloro-5-(trichloromethyl)pyridine in the absence of a catalyst.
    公开号:SU1473711A3
    申请号:SU853919403
    申请日:1985-06-07
    公开日:1989-04-15
    发明作者:Е.Гатлин Джэнис；А.Ван Дорт Марк；Л.Фолькман Куртис
    申请人:Дзе Дау Кемикал Компани (Фирма)；
    IPC主号:
    专利说明:

    one
    The invention relates to organic synthesis, in particular to a method for producing 2, 3-dichloro-5- (trifluoromethyl) pyridine, which is a valuable intermediate product for the synthesis of herbicides.
    The purpose of the invention is to simplify the process of obtaining 2, 3-dichloro-5- (trifluoromethyl) pyridine by carrying out the process in the liquid phase.
    Example. 1209.5 g (4.52 mol) of 99% 2, 3-dichloro-5-trichloromethyl-pyridine is placed in a 1-liter Hasteloy-C reactor (Parr autoclave) equipped with a baking dish and connected
    with refrigerators, heaters, means for regulating pressure and supplying hydrogen fluoride. The reactor is sealed, start heating and mixing. The pressure in the reactor is maintained within 1411.33 - -1549.22 kPa with nitrogen. When the temperature reaches 193 ° C, 46 g of hydrogen fluoride are added, after which the supply of HF is continued at an average consumption of 20 g / h (1.00 mol / h / 4.52 mol of pyridine), maintaining the temperature in the reactor at 186 ° C, pressure 1798 kPa and temperature in refrigerators 12 - 17 C. GLC analysis of the product
    Ј
    WITH
    -sj
    cm
    3 14737114
    after 38 hours, it showed a content of 5 mol.% Fed ,, pressure 83, 8 mass% 3-chloro-2-fluoro-5- (trifluorine 100-135.8 kPa, temperature 138-.
    methyl) pyridine, tK4n 139-140 ° C, and 170 ° C, and anhydrous is continuously fed
    8.0 wt.% 2,3-dichloro-5- (trifluorome-HCl for 23 h to obtain
    thyl) pyridine, tkv, n 50-51 ° C at 5 2,3-dichloro-5- (trifluoromethyl) pyridine
    6 mm Hg (90% yield).
    In the second stage, the reactor is outdated. The overall yield is 85% for 61 hours, is teased and purged with nitrogen, after
    权利要求:
    Claims (1)
    [1]
    1. METHOD FOR PRODUCING 2,3-Dichloro-5- (triftho-methyl) pyridine based on a derivative of 5- (trifluoromethylpyridine) using a chlorinating agent when heated in the presence of
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1473711A3|1989-04-15|Method of producing 2,3-dichloro-5-|pyridine
    SU1436868A3|1988-11-07|Method of producing tetronic acid
    US3303197A|1967-02-07|Method of fluorinating pentachloropytridine
    KR900004416B1|1990-06-25|Process for the selective reduction of 2-quinoxaline-4-oxides
    EP0448543B1|1995-12-06|Process for preparation of fluoromethyl-substituted pyridine carbodithioates
    KR19990082368A|1999-11-25|Continuous hydrolysis of cyanopyridine under substantial adiabatic conditions
    US4275212A|1981-06-23|Method of preparing pyridinyloxyphenols and derivatives
    US5591857A|1997-01-07|Process for the preparation of 2,3,5,6-tetrachloropyridine
    US3838136A|1974-09-24|Preparation of 2-chloro-3-aminopyridine
    US4939273A|1990-07-03|Method for conversion of ethylidene N,N'-bis-pyrrolidone into 2-pyrrolidone
    JPS5699450A|1981-08-10|Preparation of n-acyl-n-substituted formamide derivative
    JP3046137B2|2000-05-29|Preparation of 2-chloropyridine
    RU2067090C1|1996-09-27|Process for preparing carbamate
    JP2001039939A|2001-02-13|Production of malonitrile
    US4782161A|1988-11-01|Preparation of fluoropyridines
    JPH064603B2|1994-01-19|Method for producing 2-quinoxalinol compound
    SU1265193A1|1986-10-23|Method of producing 3-ethoxycarbonylaminepyridine
    SU463672A1|1975-03-15|The method of obtaining hypoxanthine or adenine
    JPS60188349A|1985-09-25|Preparation of 2,3-dichloro-6-nitrophenol
    SU891660A1|1981-12-23|Method of preparing n-methyl pyridinium chloride
    JPS6425759A|1989-01-27|2,6-dichloropyridine derivative
    US4891108A|1990-01-02|Process for preparing tetrahalopyridines
    JP3463937B2|2003-11-05|Production of 2,3,5,6-tetrachloropyridine
    US4225719A|1980-09-30|Process for preparing 2-amino-5-formylthiazole and its hydrobromide salt
    SU759510A1|1980-08-30|Method of preparing 3-ethylpyridine
    同族专利:
    公开号 | 公开日
    AU570801B2|1988-03-24|
    BR8502718A|1986-02-12|
    AU4271285A|1985-12-12|
    CS248745B2|1987-02-12|
    EP0164104A2|1985-12-11|
    JPS611662A|1986-01-07|
    EP0164104A3|1988-08-03|
    HU199122B|1990-01-29|
    DK159422B|1990-10-15|
    DE3585702D1|1992-04-30|
    DK159422C|1991-03-18|
    JPH0625111B2|1994-04-06|
    DK255485A|1985-12-09|
    EP0164104B1|1992-03-25|
    CA1199331A|1986-01-14|
    HUT38316A|1986-05-28|
    US4547577A|1985-10-15|
    DK255485D0|1985-06-06|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB1039987A|1964-03-17|1966-08-24|Pennwalt Corp|Fluoropyridines|
    GB1272475A|1969-05-30|1972-04-26|Ici Ltd|Manufacture of fluoropyridines|
    DE2862492D1|1977-08-12|1988-09-01|Ici Plc|Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith|
    JPS5461183A|1977-10-21|1979-05-17|Ishihara Sangyo Kaisha Ltd|2-substituted-5-trifluoromethyl pyridine compounds|
    JPS5585564A|1978-12-22|1980-06-27|Ishihara Sangyo Kaisha Ltd|Preparation of beta-trifluoromethylpyridine|
    JPS55158979A|1979-05-29|1980-12-10|Seiko Epson Corp|Ink jet recording head|
    EP0074192B1|1981-09-03|1986-12-30|Imperial Chemical Industries Plc|Chloro-trifluoromethyl pyridines|
    US4567273A|1982-04-16|1986-01-28|The Dow Chemical Company|Liquid phase halogen exchange of pyridines to pyridines|
    US4493932A|1982-09-13|1985-01-15|The Dow Chemical Company|Chlorine exchange for fluorine in 2-fluoro-pyridine compounds|
    IL70307A|1982-11-26|1987-02-27|Dow Chemical Co|Preparation ofpyridines|EP0063872B1|1981-04-27|1985-07-17|Imperial Chemical Industries Plc|Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom|
    US4782161A|1987-10-21|1988-11-01|The Dow Chemical Company|Preparation of fluoropyridines|
    US4999432A|1989-08-28|1991-03-12|Dowelanco|Fluorination with hydrogen fluoride|
    CN107954924A|2016-10-18|2018-04-24|内蒙古佳瑞米精细化工有限公司|A kind of preparation method of the fluoro- 3- chloro-5-trifluoromethylpyridines of 2-|
    CN107935920A|2017-11-30|2018-04-20|山东汇盟生物科技有限公司|The preparation method of 2 fluorine, 3 chlorine, 5 trifluoromethyl pyridine|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US06/618,806|US4547577A|1984-06-08|1984-06-08|Preparation of pyridines|
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