• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A method is disclosed for the sealing of gelatin capsules having hard shell coaxial cap and body parts which overlap when telescopically joined. Also described are apparatus and sealing fluids to seal the capsules. …<??>The method comprises sealing the cap and body parts by the application of thermal energy, or a sealing fluid and thermal energy, to the region of overlap of the cap and body parts. …<??>An apparatus for performing the method is also disclosed. The apparatus comprises: a funnel (5) for receiving the capsules (4) and applying them to a conveyor (14); wetting means (6,7) for applying sealing fluid to the capsules; drying means (9) for removing excess fluid from the capsules; and a energy source (15) for applying thermal energy to the capsules.
    公开号:SU1393309A3
    申请号:SU833655358
    申请日:1983-10-17
    公开日:1988-04-30
    发明作者:Виттвер Фритц；Томка Иван
    申请人:Варнер-Ламберт Компани (Фирма)；
    IPC主号:
    专利说明:

     s
    The invention relates to the medical industry and can be used to encapsulate capsules.
    The purpose of the invention is to improve the reliability of sealing, |
    The method is carried out as follows.
    Gelatin Kaisulu is moistened with a sealing liquid that dissolves the amorphous part l; epatina between the overlap of the side walls of the body
    capsules. In addition, the encapsulating fluid may partially lower the melting point of the crystalline portion of gelatin.
    After wetting, the capsule is dried by means of an air jet at room temperature, followed by heating the overlapping zone of the body and the cover at a temperature above the melting point of gelatin. When this occurs, the cap overlaps the cap with the capsule body, ensuring full contact of the surface of the coating wall and thus obtaining a strong seam. This is due to the fact that the specific volume of gelatin | is changing. Wetting the capsule can be accomplished by spraying it with a sealing liquid, which can be an aqueous solution of alcohol, preferably an aqueous solution of ethanol. In this case, the sealing liquid may contain an organic solvent for lowering the melting point of the gelatin, which has solubility parameters in the di-: 10-23.4 (cal / cm) range, and a solution of water or salt is selected from the series. acids, or bases of salt, or water solution of organic solvent and salt in corresponding acids or bases of salt with cations and anions of salt, or polymer solution, or emulsion, or any of the mentioned liquids with added proteolytic enzyme E to create a zone of overlap capsules protein distributed create. Organic solvents with specified solubility parameters, miscible with water, increase the drying efficiency.
    The effect of cations and anions of salts is to lower the melting point of Gelatin.
    Cations are extremely efficient if their charge is high, and
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    the radius is small, which gives a strong polarization according to the range of the outmaster, the Anions must have a large electronic cloud to provide a strong ability to polarize. The PL sealing pharmaceutical gelatin capsules use only pharmaceutically acceptable salts.
    Heating can be accomplished by electromagnetic irradiation with a laser or electromagnetic irradiation with a frequency of 2.4 GHz and a field strength of about 200 V / cm, since microwaves, with such a field strength, cause effective peptization and denaturation; 11; thereby a strong physical bond and tightness of the joint, the conventional medium can be heated air, and the hot metal can be used in the form of a stamp or rod coated with a non-stick material, preferably on dimetmsilicon or polytetrafluoroethylene.
    The organic solvent can be any one with solubility parameters in the range of 10-23.4 (cal / cm) and sufficiently miscible with water.
    Example 1. 100 capsules of size 2 were filled with rep oil, combined and placed in a sieve, which was coated with another sieve. The capsules were completely immersed for 3 seconds in a sealing liquid consisting of 60% ethanol, 40% water and 0.1% sodium lauryl sulfate at 5 ° C. Excess sealing liquid was removed from the surface of k-capsule within 10 s by means of a strong air jet at room temperature. Then the capsules were placed in a conveyor system and fed to the treatment zone, where they were heated to a temperature of about 80 ° C for 20 s. Local application of thermal energy to the overlap of the housing and the cover is required so that during the sealing procedure, the heat expandable liquid content displaces the air between the housing and the cap.
    Example 2. 50 capsules of size 2 were filled with rep oil, combined and placed in a sieve. The capsules were sprayed with a sealing liquid consisting of water containing 0.1%.
    sodium lauryl sulfate at. After sprinkling, the screen was covered with another screen. Excessive current medium was removed from the surface by means of an air jet at room temperature and a relative humidity of 20% for 20 s. To obtain a strong bond in the overlap of the cap and the body of the capsule, it was irradiated for 4 with electromagnetic energy at a frequency of 2.4 Hz with a field strength of 171 V / cm. All capsules were sealed.
    Example 3. The same as in example 1, and the sealing liquid is a 60% ethanol solution in water (40%).
    Example 4. 10 capsules of size 2 were filled with rep oil and combined. A full connection over a 360 ° angle of the overlap circumference was obtained by locally applying thermal energy through three metal stamps (rods) coated with teflon, each of which sealed the overlapping sector 120 °.
    Example 5. Same as in example 1. Heating was performed using an infrared lamp for 90 s at 60 ° C.
    Example 6. As in example 1, the sealing liquid consists of an aqueous solution of 1.5% hydrolyzed gelatin with an average molecular weight of about 2000 daltons and 0.1% sodium lauryl sulfate at. At the same time, in order to obtain a strong connection to the overlapping of the cap with the body of the capsule, it was irradiated for 4 with electromagnetic energy at a frequency of 2.4 Hz at a field strength of 171 V / cm.
    Example 7. Same as Example 1. The sealing fluid consists of an aqueous solution of 1% polyvinylpyrrolipid (average mol. Weight 25,000 Dalton) containing 0.1% sodium lauryl sulfate.
    权利要求:
    Claims (7)
    [1]
    1. A method of sealing a hard-top gelatin capsule consisting of telescopically connected, coaxially arranged lids and a body, consisting in wetting the capsule with a sealing liquid
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    and drying it, characterized in that, in order to increase the reliability of the sealing, the capsule is dried by means of an air jet at room temperature, followed by heating the overlapping zone of the body and lid at a temperature above the melting point of gelatin.
    [2]
    2. A method pop, 1, characterized in that the wetting of the capsule is carried out by spraying it with a sealing liquid.
    [3]
    3. A method according to claim 1, characterized in that the sealing liquid is an aqueous solution of alcohol, preferably an aqueous solution of ethanol.
    [4]
    4. A method according to claim 2, characterized in that the sealing liquid contains an organic solvent for lowering the melting point of gelatin, having solubility parameters in the range of 10-23.4 (cal / cm), and is selected from the range of water solution or - stems acids, or bases of salt, or an aqueous solution of an organic solvent and salt in the corresponding acids or bases of salts, with cations and anions of salt, or a polymer solution, or emulsion, or any of the above-mentioned liquids with additional proteolite eski- mi enzymes to create a zone of overlapping protein solution capsules.
    [5]
    5. The method according to claim 1, characterized in that the heating is carried out by electromagnetic irradiation with a laser or electromagnetic irradiation with a frequency of about
    2.4 GHz and a field voltage of 200 V / cm or infrared heating, or convection heating, or conductive heating to the hot metal used in the overlap zone, or friction resulting from ultrasonic vibration.
    [6]
    6. The method according to claim 5, characterized in that the convection medium is heated air.
    [7]
    7. A method according to claim 5, characterized in that the hot metal is used in the form of a stamp and a rod coated with a non-adherent material, preferably dimethyl silicon or polytetrafluoroethylene.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1393309A3|1988-04-30|Method of hermetic sealing of hard-shell gelatin capsule consisting of cover and casing telescopically connected and coaxially located
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    US4528991A|1985-07-16|Microwave applicator for creating local hyperthermias
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    ES477373A1|1979-12-16|Method of preparing foodstuffs containing coagulating proteins and a device for performing the method
    KR840006904A|1984-12-04|Capsule sealing device and method
    USRE33251E|1990-07-03|Apparatus and method of sealing capsules
    EA200200195A1|2002-06-27|METHOD AND APPARATUS FOR SEALING CAPSULES, AND ALSO CAPSULES SUITABLE FOR USE IN SPECIFIED METHODS AND APPARATUS
    CA1219214A|1987-03-17|Sealed capsule
    JP2551881B2|1996-11-06|Freeze-drying container and method for producing freeze-dried drug in filled container
    JPS54119357A|1979-09-17|Solder coating and soldering method for aluminum
    SU1436857A3|1988-11-07|Method of hermetic sealing of capsules
    EP0129130B1|1988-02-24|Apparatus for sealing capsules
    JPS57206346A|1982-12-17|Preparation of gelatinous product
    JPH01225140A|1989-09-08|Manufacture of semiconductor device
    JPS621452A|1987-01-07|Preparation of microcapsule having heat accumulating material sealed therein
    JP3160903B2|2001-04-25|Heat sterilization method
    SU380123A1|1973-12-10|METHOD OF EXTRACING OF GELING SUBSTANCES
    RU97114421A|1999-06-20|METHOD AND DEVICE FOR PRODUCING OIL
    KR20010049740A|2001-06-15|Heat-sterilization apparatus for heating and sterilizing a flowable foodstuff
    JPS5927192A|1984-02-13|Latent heat accumulating body and using method thereof
    JPS5867168A|1983-04-21|Preparation of granular capsule containing liquid food
    同族专利:
    公开号 | 公开日
    JPH0140627B2|1989-08-30|
    IE56363B1|1991-07-03|
    JPS59156349A|1984-09-05|
    ES526230A0|1984-12-16|
    CA1255271A|1989-06-06|
    IE832820L|1984-08-18|
    BR8306208A|1984-11-13|
    KR890000206B1|1989-03-10|
    AU1977383A|1984-08-23|
    US4539060A|1985-09-03|
    IN160442B|1987-07-11|
    EP0116743A1|1984-08-29|
    EP0116743B1|1988-04-06|
    YU44447B|1990-08-31|
    AU559678B2|1987-03-19|
    PH20191A|1986-10-16|
    ES8501976A1|1984-12-16|
    DE3376197D1|1988-05-11|
    KR840007664A|1984-12-20|
    AT33346T|1988-04-15|
    YU219583A|1986-02-28|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US06/468,022|US4539060A|1983-02-18|1983-02-18|Apparatus and method of sealing capsules|
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