• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to pyridine derivatives, in particular, aminopyridine hydroxides and their quaternary salts of the formulas g-Rr Cl-5-StO), NH,) I -N CRj-CH CT j-CH-tR, CAn) OR | gRrWbS-S (CfttNHrCjH C "BNH-tJ CRrCH CRrCH-CR,} - cf (CAn1, where either the 2-furylmethylamino group R {, Ri, R are the same lower alkyl or phenyl that have diuretic activity and can be used in medicine. The purpose is to develop a method for obtaining new ones substances of the indicated class with better activity. Synthesis of APs is carried out from the corresponding sulfonoylbenzoylhydrazide in tetrafluoroboratopyryl in a lower alcohol at a boiling point. nii (4-15 hours) followed by treatment with KOH. Synthesis of SAP is carried out by treating AP with hydrochloric acid in ethanol. Tests of pyridine derivatives show their non-toxicity and higher diuretic activity than chlorothalidone. Table 4 (Y)
    公开号:SU1376943A3
    申请号:SU843697650
    申请日:1984-02-07
    公开日:1988-02-23
    发明作者:Эстев Солер Хосе
    申请人:Провезан С.А (Фирма)；
    IPC主号:
    专利说明:

    with about
    UD
    N
    WITH
    h
     CH
    one
    This invention relates to a process for the preparation of new derivatives of aminopyridine hydroxide of the formula
    Cs
    H21S02S
    (I)
    or their Quaternary salts of formula 3
    C1
    RI
    H2N02S
    (Ii)
    where R is hydrogen or a 2-furylmethylamino group; R2, R is identical lower alkyl or
    phenyl,
    which have diuretic activity and can therefore be used in medicine.
    The purpose of the invention is to develop a method for producing new derivatives from the class of aminopyridines of formula (I), which would have a high diuretic activity as compared with the known ones, for example, chlorthalidone 1-oxo-3- (3-sulfamoyl-4-chlorophenyl) -3 -oxyisoindoline.
    Example 1. Preparation of 1- (4-chloro-3-sulphamoylbenzoyl) amino--2,4,6-trimethylpyridinium hydroxide hydroxide internal salt.
    Leave at boiling for
    4 h solution of tetrafluoroborate trimethyl-, nylpyryl (3.96 g; 0.01 mol) and 4-pyrily (3.87ir; 0.0184 mol), tol-chloro-3-sulfamoylbenzylhydrazide, and 4-chloro-3 -sul- (2.97 g; 0.011 mol) in ethanol (50 wx). famoyl benzoyl hydrazide (5.06 g; 0.0203 mol) in ethanol (60 ml). Cool with stirring to room temperature and add 85% potassium hydroxide (1.22 g; 0.0185 mol). Stir for 1 h at room temperature, heat to kiOhlazhdat with stirring to room temperature and add 85% 55 potassium hydroxide (0.68 g; 0.0103 mol) Maintain for 15 min with stirring and filter. The filtrate is evaporated to dryness, recrystallized from benzene to obtain 3.0 g.
    1376943
    o
    five
    g
    chimes, potassium tetrafluoroborate and npoNibiBaroT precipitate are filtered off with ethanol at a hot state. 4.93 g (76%) of the inner salt of 1- C (4-chloro-3-sulphamoyl-benzoyl) -amino-2,4,6-trimethylpyridinium hydroxide is obtained by crystallization from a concentrated alcohol solution. M.p. 264-265 C.
    IR spectrum (KVG), cm 1640 $ 1595; 1545; 1360, 1335; 1165.
    Н-spectrum of nuclear magnetic resonance, s /, DMSO (dj): 2.5 (S, 9H); 3.5 (1, 2H); 7.55 (s, 2H); 7.60 (d, 1H); 8.15 (g, 1H); 8.65 (d, 1H).
    Example 2. Preparation of 1- and 4-chloro-2-furylmethylamino) -5-sulfamoylbenzosh1 amino} -2,4,6-trimethylpyridinium hydroxide hydroxide.
    A solution of tetrafluoride tetrafluoroborate (3.87 g; 0.0184 mol) and 4-chloro-2- (2-furylmethylamino) -5-sulpha-5 mobenzoylhydrazide (7.21 g ;
    0.02 mol) in 70 ml of ethanol. Cool to room temperature with stirring, add 85% potassium hydroxide (1.22 g; 0.0185 mol) and keep stirring 1 for 1 hour. Filter and extract several times with ethanol. The alcohol solution is concentrated and 4.7 g (55%) of the internal salt of hydroxide 1-1 4-chloro-2 (2-furylmethylamino) -5- sulfamoylbenzoyl amino -2,4,6-tri0 is obtained
    0
    methylpyridinium. M.p. 274-275 C.
    IR spectrum (KBG), cm-: 1638; 1600; 1560; 1355; 1340; 1260; 1165.
    H NMR Spectrum, 4 DMSO (d): 2.5 (S, 9H); 4.51 (s, 2H); 6.35 (d, 2H); 6.92 (S, 1H); 7.18 (s, 2H); 7.62 (S, 3N); 8.63 (s, 1H); 9.5 (1, 1H).
    Example 3. Preparation of 1- (4-chloro-3-sulfamoylbenzoyl) amino-2,4,6-triphenylpyridinium hydroxide;
    A triphenylpyryl tetrafluoroborate solution (3.96 g; 0.01 mol) and 4-chloro-3-sulfamoylbenzyl hydrazide (2.97 g; 0.011 mol) in ethanol (50 sk) were left at the boil for 15 hours.
    Cool with stirring to room temperature and add 85% potassium hydroxide (0.68 g; 0.0103 mol). Maintain for 15 min with stirring and filter. The filtrate is evaporated to dryness, recrystallized from benzene to obtain 3.0 g.
    (52%) of the internal salt of the hydroxide
    1-G (4-chloro-3-sulfamoi.benzoyl) amino 2, 4,6-triphenylpyridinium. M.p. 170nz-c.
    IR spectrum (KBG), cm: 1628; 1600; 1550; 1350; 1165.
     H NMR Spectrum, (d): 7.2-7.85 (m, 17H); 7.92-8.25 (m, 5H).
    Example 4. Preparation of 1- (4-chloro-3-sulfamoyl. Pbenzoyl) amine -2,4, 6-trimethylpyridinium chloride.
    10 ml of ethanol saturated with hydrochloric acid are added with stirring.
    Under stirring, add 10 ml of ethanol, saturated with hydrochloric acid, to a solution of the inner salt of 1- (4-chloro-3-sulphamoyl-benzoyl) amine hydroxide 2,4,6-triphenylpyridinium (5.4 g; 0.01 g ) in the stanelle (25 ml). After half an hour of stirring, the precipitate formed is filtered and 5.2 g (90%) of chloride 1- (4-chler-3-sulfamethylbenzoyl) amine -2,4,6-triphenylpyridinium are obtained. M.p. 290-292 S.
    IR Spectrum (KVg), 1700; 1628; 1340; 1170.
     H NMR spectrum, J, G DMSO (d J:
    1 / g
    reekis 1 (4-chler-3-sulfameylbenzene) amino -2,4,6-trimetnylpyridinium (3.5 g; 0.01 stranded) in ethanele (80 ml) After 1 hour of stirring, fuse the precipitates are filtered and this is nel. 3.6 g (92%) of 1- (4-chlorine-3-sulfameylbenzene1) am-, 4,6-trimethylpyridinium are obtained. M.p. 272-274 s.
    IR spectrum (KBG), cm 1705; 1642; , give a suspended state
    .., - cRPvrnPWQMMS - FOLLOWED nfir irr Mx p tygir nnui-
     H NMR spectrum, tDMSO (d) 2.6 (S, 3N); 2.7 (s, 6H); 4.85 (1, 2H); 7.7-8.05 (m, 2H); 8.35-8.65 (m,
    2H).
    Example 5. Obtaining the cleririd is a metabelistic cell and collects the entire 1-a4-hler-2- (2-flux-1-amine) -5- isolated after the following presulfamel-benzoyl-amine-2,4,6-trimethyl-pyridinium hydrochloride.
    20
    Tey, to the solution of the internal mudsid-.
     -. - 5 5 (1, ЗН); 7.25-7.73 (t, 11H);
    7.73-8.3 (ha, 7H); 8.53 (s, 2H).
    Compounds (1) exhibit diuretic activity. Mechegenic activity.
    Sprague-Dawley male rats (HC / CPu) weighing 150-200 g are used. The animals are stopped for 16 hours before the start of the experiment. The products give a suspended state in a suspension of 5th carboxymethylcellulose, in a solution of 0.9% sodium chloride with a mixture of food and a probe at the rate of 50 ml / kg body weight. Animals are placed in individual
    Add 20 ml with stirring.
    time interval, h: 1, 2, 3, 4, 5, 6 and 8.
    In the sword, the following para etanel-17-centered acidic 35 meters are determined: consumption (ml, kg): sodium and cat, to the inner mud suspension — ™ (meq / kg / h) (plasma fetemeter) -, reekis 1- and 4 -Hler-2- (2-fur-1 methyl chloride (meq / kg for 8 h) (device for ismine) -5-sulfameyl benzene-amine 5-measure of ferride); pH / 8 h (instrument for 2,4,6-trimethylpyridinium (4.6 g; pH measurement) and osmotic pressure — 0.01 stranded) in ethanele (40 ml). In practice (40 cm / sq / 8 h) (osmometer). For several seconds, pre-Central animals are bruised to obtain a clear solution, and the immediate 0.5% carboxymethylcellulose suspension begins to precipitate. Filtered, proloses in a solution of 0.9% fermentation are ethanel and 4.9 g (98%) of that sodium is added at the rate of 50 ml / kg of the weight of hlorhidrat 1- C4-chloro-2- (2-45 body.
    furilmetsh1amine) -5-sulfamelbenzenerim of statistical experience
    studies of t for independent values compare the values of the parameters indicated earlier, the animal batches, ebra-IR spectrum (KBr), cm: 1668; 1635; 50 betan with a diarrhea of 40 mg / kg, and batches of 1565; 1355; 1165.controlled living. It is believed that
    H NMR spectrum, s /, DMSO (e (,): the preduct has a diuretic active, 2.6 (S, .3H), 2.7 (S, 6H), 4.6 (S, 2H); when the difference between control is 5-6 (1, 5H); 6.4. (d, 2H); 7.1 (S, 1H); her party and processed party 7.6 (S, 1H); 7.95 (S, 2H); 8.73 (S, 55 more significant (P 0.05). 1H). Table 1 shows the swords volumes,
    Example 6. Preparation of 1- (4- isolated at various intervals of Hler-3-sulphamoylbenzene) amino -2.4, the time of administration of 40 mg / kg of 6-triphenylpyridinium chloride for the various proposed compounds.
    or amine -2,4,6-trimethylpyridinium. M.p. 257-258 C.
    In tab. 3 shows the effective fifth doses corresponding to the volume of urine and osmotic pressure.
    Table 1
    Compounds of Example 1 compared with chlorthalidone.
    Chlorta-lidon
    6.9
    7.7
    DEUD is calculated from the direct regression of the presentation of the decimal logarithm of the dose relative to the percentage of the effect obtained.
    According to the table. 3, the proposed compound of Example 1 is better than chloro-talidone, since its fifty effective doses are 1.5-1.7 times less for urine volume and 3.6-6.4 times less for osmotic pressure. Acute toxicity is observed.
    The compound is administered orally in suspension in 5% gum arabic to CELP-PE albino mice weighing 20-25 g and Sprague-Dawley CFY-RE rats weighing 125-175 g. The assigned volume is 25 ml / kg for an intact mouse. a maximum dose of 12.800 mg / kg, where a volume of 50 ml / kg was prescribed, and 10 ml / kg in an intact rat for a maximum dose of 12.800 mg / kg, where a volume of 30 ml / kg was prescribed.
    It is impossible to determine the lethal dose of 50 due to the fact that there is no mortality.
    The results of the studies in example 1 are presented in table. four.
    Table 4
    15
    20
    H2N02S
    where r
    - hydrogen or 2-ferylmethylamino group; R, i, R jH R-identical lower alkyl
    or phenyl,
    characterized in that a hydrazide of the formula
    35
    H2NOjS
    (Iii)
    40
    where R has the indicated meanings, is reacted with a pyryl salt of the formula
    45
    50
    R (IV)
    Bfi,
    权利要求:
    Claims (1)
    [1]
    Claim
    A method of obtaining derivatives of aminopyridinium hydroxide of the formula (I) or their quaternary salts of the formula (II)
    I
    C = 0 (ID h 2 no 2 s where R η is hydrogen or a 2-ferylmethylamino group;
    R 2 , R 3 and R 4 are the same lower alkyl or phenyl, characterized in that / hydrazide of the formula Ex 2 mn pl =
    Cl (in) where R 4 has the indicated values, is reacted with the pyrilium salt of the formula (IV) where R 2 - R + have the indicated meanings, in lower alcohol when boiled for 4- ^ 15 hours, followed by treatment of the reaction mass with potassium hydroxide and isolating the desired product of formula (I) or treating the latter with hydrochloric acid in ethanol to obtain its quaternary salt.
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    US5670480A|1994-01-05|1997-09-23|Arqule, Inc.|Method of making polymers having specific properties|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR8302380A|FR2540870B1|1983-02-15|1983-02-15|
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