瑞典专利SE1000466A1 Syringe with expandable element

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专利摘要:
The invention relates to a syringe comprising a cylindrical container (1) in which runs a first piston (5, Sa-b) which delimits a storage space. The syringe is provided with an expandable element (16a-b) which closely delimits the storage space and is in intermediate communication the intermediate storage space and the environment of the syringe. This enables the syringe to remain tight even if the pressure of the substance in the storage space increases. It can be used for heat sterilization or by drying the substance in the syringe. In a form of desiccation, the syringe comprises a first (Sa) piston and a second piston (Sb). The two piston alarms then define two storage spaces which can be used for storing freeze-dried substance or solvent for the ﬁy-dried substance. The different substances are affected very differently by sterilization with heat, which can give rise to a pressure difference between storage spaces, but this compensates for the expandable element so that no leaks occur between them. The invention also relates to a cassette for mounting, filling and sterilizing such a syringe. 9/31 16
公开号:SE1000466A1
申请号:SE1000466
申请日:2010-05-06
公开日:2011-11-07
发明作者:Jan Svensson
申请人:Jan Svensson；
IPC主号:

专利说明:

An object of the invention is therefore to provide a syringe with an expandable element which reduces the risk of leakage during sterilization by heating or during ﬁ drying.
Another object of the invention is to provide a cassette for use in mounting, filling and sterilizing such a syringe.
These and other objects are achieved by a syringe with an expandable element and a cassette for use with such a syringe according to the characterizing parts of the independent claims.
Summary of the invention The invention relates to a syringe comprising a cylindrical container 1 in which runs at least a first piston 5, 5a-b which delimits at least one storage space. The syringe is provided with at least one expandable element lóa-b which tightly delimits the storage space and is in ﬂ uid communication between the storage space and the environment of the syringe. This allows the syringe to remain tight even if the pressure of substance in the storage space increases. It can be advantageously used for heat sterilization or for freeze-drying of substance in the syringe. In one embodiment, the expandable element 16a ~ b is constituted by a bellows.
In a particularly advantageous embodiment, the syringe comprises at least a first piston Sa with a first piston rod 12 and a second piston 5b with a second piston rod 13, where the first piston rod 12 and the second piston rod 12 can be locked against each other with a locking element 15. The two pistons they then två deny two storage spaces which can be used particularly advantageously for storage of ﬁ cheese-dried substance and solvent for the freeze-dried substance, respectively. The different substances are affected very differently by sterilization with heat, which can give rise to a pressure difference between storage spaces, but this compensates for the expandable element so that no leaks occur between them.
In a further particularly advantageous embodiment, the second piston 5b is provided with a sealing element 7b which is sealing unloaded, under load lets pass in a first direction while under load does not let pass in a second direction. This allows later mixing of the two substances, but keeps them separate during storage, sterilization and freeze-drying.
The invention furthermore relates to a cassette for mounting, filling and sterilizing such a syringe, wherein the cassette comprises receiving plates 21, 22, 25, 27a-c, where at least one of the receiving plates comprises openings 24 for receiving such syringes and where at least one of the receiving plates comprises openings 26, 30 which can be arranged in communication with at least one expandable element 16a-bi at least one syringe. This allows a larger number of syringes in such a cassette to be sterilized simultaneously.
Brief description of the figures F ig. 1 shows a longitudinal cross-section through a two-chamber syringe according to the prior art.
Fig. 2 shows a cross section perpendicular to the longitudinal axis of a two-chamber syringe according to the prior art.
Fig. 3 shows a fully assembled and filled syringe according to the invention.
Fig. 4 shows a cross section through a syringe according to the invention in a first step in the filling process.
Fig. 5 shows the upper end of the syringe with a locking device.
F ig. 6 shows an expandable plug for use with the syringe according to the invention.
Fig. 7 shows an orifice part for use with the syringe.
Fig. 8 shows a cross section through a syringe according to the invention in a second step in the filling process.
Fig. 9 shows a cross section through a syringe according to the invention in a third step in the filling process.
Fig. 10 shows in greater detail the mouth of the syringe.
F ig. 11 shows in greater detail the upper piston of the syringe with bellows.
Fig. 12 shows the syringe when mixing the substances in the chambers.
Fig. 13 shows in greater detail the lower piston of the syringe. Fig. 14 shows the upper end of the syringe with a locking device.
F ig. 15 shows the syringe when the substances in the chambers are mixed.
Fig. 16 shows in greater detail the upper piston of the syringe with bellows after mixing.
F ig. Fig. 17 shows the syringe during dispensing of mixed substance. Fig. 18 shows in greater detail part of the upper piston of the syringe with one bellows.
F ig. 19 shows a cassette in a first assembly, filling and sterilization step.
Fig. 20 shows the cassette in a second assembly, filling and sterilization step.
Fig. 21 shows the cassette turned upside down in a third assembly, filling and sterilizing step.
Fig. 22 shows the cassette turned upside down in a fourth assembly, filling and sterilizing step.
Fig. 23 shows a first variant of the cassette turned upside down in a fourth assembly, filling and sterilization step.
F ig. 24 shows a detail of the first variant of the cassette F ig. 25 shows a second variant of the cassette turned upside down in a fourth assembly, filling and sterilizing step.
Fig. 26 shows a detail in the second variant of the cassette F ig. 27 shows a cassette in a first assembly step.
Fig. 28 shows in greater detail the cassette in the first mounting step.
F ig. Fig. 29 shows the upper piston and the outer piston rod separately. Fig. 30 shows separately the grip 14 for the inner piston rod Figs. 31 shows separately a locking element 15 for the inner piston rod Description of preferred embodiments F ig. 1 shows a longitudinal cross-section through a two-chamber syringe according to the prior art.
The two-chamber cushion comprises a substantially cylindrical container 1 with a spout 2 at the lower end and an upper seal 3 at the upper end. At the spout is a lower seal 4 and in the space between the upper 3 and the lower seal 4 there is a storage space for substances for medical use.
The storage space is divided by a piston 5 into an upper storage space and a lower storage space.
The piston is surrounded around its periphery by a sealing ring which normally keeps the substances in the two storage spaces separate. The sealing ring is designed to let liquid pass in one direction at a relatively low pressure difference with blocking liquid flow in the other direction even at a comparatively high pressure difference, in the manner described in, for example, SE0900798-0.
A user can apply kra ﬁ to the piston with a piston rod 6 running through a tight opening in the upper seal 3. By pulling the piston upwards, the substance in the upper storage space is forced past the sealing ring and mixed with the substance in the lower storage space.
The user can then push the plunger downwards and dispense the mixed substances through the spout.
In a typical application, dry, lyophilized substance is stored in the lower storage space and saline solution in the upper storage space. As long as a user does not apply force to the piston rod, the two substances are kept separate and the dry, lyophilized substance then has a long pouring time. During freeze-drying, the water in the upper storage space can freeze and then expand. During expansion, ice can force past the sealing ring and mix when it melts with the freeze-dried substance which then begins to dry out. During sterilization with heating, the steam pressure in the upper storage space increases instead so that steam or liquid can be forced past the sealing ring, which also means that the ﬁ-dried substance begins to be experienced.
Fig. 2 shows a cross section perpendicular to the longitudinal axis of such a two-chamber syringe according to the prior art. The figure shows a cross section through the cylindrical container 1 and illustrates an element annular in cross section 5.
F ig. 3 shows a fully assembled and filled syringe according to the invention. The syringe comprises a cylindrical container I, typically formed of glass or semi-transparent plastic, but the illustration does not show the inner details of the syringe but only its outer surfaces. At the lower end of the container there is a spout 2 on a mouth part 8 which is sealingly connected to the open lower end of the cylindrical container.
The spout 2 is closed with a lid 9 so that the lower end after filling is completely tight.
At the other end of the cylinder there is an abutment 10 which the user can use to push away towards when the piston rod is to be pushed or pulled in one or the other direction. In the interior of the cylinder two piston rods run one inside the other, of which only the outer piston rod 12 is visible. With the syringe filled and sterilized, typically containing at least one ﬁ-dried substance, the syringe can be stored for a long time without the contents being frozen. Thereafter, the substances can be mixed and then discharged in the manner described in connection with ﬁ gures 12-18. When dispensing for injection, the syringe can be fitted with an injection needle or connected to a tube for intravenous delivery of substance to the bloodstream.
Pig. 4 shows a cross section through a syringe according to the invention in a first step in the filling process. The cylindrical container 1 is in this step open at its lower end. An upper piston Sa and a lower piston Sb are arranged in the cylindrical container. The two pistons define an upper and a lower storage space, where the upper storage space extends between the pistons while the lower storage space extends from the lower piston 5b and the lower end of the cylinder. The upper storage space is filled with saline solution, which is indicated by the line in this space, while the lower storage space is still empty. An outer piston rod 12 is connected to the upper piston 5a and an inner piston rod 13 is connected to the lower piston 5b, which runs inside the outer . The inner piston rod is sealing but slidably arranged inside the outer, so that the piston rods can run relative to each other without substance being able to leak out or air leaking in between the piston rods.
The inner piston rod is provided at the end facing from the lower piston with a grip 14 which makes it easier to pull or slide the lower piston. In the illustrated first step in the filling process, the two piston rods are locked in each other with a lock 15 which is more clearly illustrated in ﬁ g. 5.
The lower piston is provided with a sealing ring 7b of a type described in SE09007 98-0.
The sealing ring extends towards the inner surface of the cylindrical container 1 and normally seals against it, but bends at the far end towards the inner surface unloaded towards the lower end. This means that with a lower pressure difference between the two storage spaces, it allows liquid to flow from the upper to the lower, while a considerably higher pressure difference is required to cause liquid to flow past the sealing ring from the lower to the upper storage space. The sealing ring is designed not to allow liquid to leak from the lower to the upper storage space under any normal pressure differences, while the reverse is allowed only when a user applies a sufficient force ﬁ to achieve such a flow.
The upper piston 5a comprises a seal 7a which seals against the inner surface of the cylinder and is not designed to preferentially pass past in one direction, but is intended to always seal. The upper piston has in its center an opening through which the inner piston rod runs and the piston seals against the inner piston rod. On the upper piston there are also two bellows 16a-b arranged which are sealingly connected to the piston, but can expand or be compressed. The bellows constitute an example of the type of element which for the sake of simplicity is referred to as expandable element in the claims, but the designation is not intended to be limiting but refers to expandable and / or compressible elements.
The first 16a and second bellows 16b are hollow and approximately cylindrical with a closed lower end and an open upper end. The approximately cylindrical outer surfaces of the bellows are accordion-like formed with a series of projecting annular portions separated by a series of annular portions of smaller radius. In the uren gure, the bellows are illustrated in cross section and appear to have zig-zag-shaped right and left sides. The accordion-shaped design makes it easier for the bellows to expand and compress at varying pressure differences between the inside and outside of the bellows.
The inside of the bellows is in communication with the outside of the syringe via channels 17 a-b, which reach the inner cavity of the bellows via their open upper surfaces. If a pressure difference occurs between the upper storage space and the environment of the syringe or if the substance in the upper storage space expands or is compressed, the bellows can expand or be compressed to compensate for this pressure difference. The bellows are made of a ﬁ resilient but resilient material, such as rubber, and strive to return to their unloaded condition. In the ﬁ guren there is no pressure difference between the upper storage space and the environment of the syringe, so the bellows have the shape they have when they are unloaded.
F ig. 5 shows the upper end of the syringe with its locking device which keeps the two piston rods locked to each other. The lock can be opened so that the piston rods and thus the pistons can move relative to each other. Upon delivery to the customer, the lock settles in the locked position and thus normally prevents the pistons from moving relative to each other, so that the substances in the two storage devices do not inadvertently mix. The inner piston rod comprises a locking element 15 which extends at a right angle from the longitudinal extent of the piston rod and out through a groove in the outer piston rod. The groove extends part of the circumference of the outer piston rod and connects at one end to a groove which extends upwards and is open towards the upper surface of the outer piston rod. By rotating the inner piston rod about its center axis, the locking element 15 can be rotated between a position in the groove which does not connect to the groove which extends upwards and an opposite position where the locking element 15 lies below the groove which extends upwards. The pistons are in these respective positions locked together and movable in the axial direction relative to each other.
F ig. 6 shows an expandable plug 18 for use with the syringe according to the invention when also the lower storage space is to be sterilized with heat. The plug is intended to be connected to the lower opening of the cylindrical container 1 so that the container is sealed. The plug comprises at its lower end a third bellows l6c of approximately the same design as the first l6a and second lobes. If the lower storage space is to be sterilized with heat, the third bellows l6c can expand and compensate for the pressure increase so that no leakage occurs between the storage spaces.
Fig. 7 shows an orifice part 8 for use with the syringe. The mouth part is received on the lower opening of the cylindrical container 1 so that the container is sealed in the same way as the expandable plug. The mouth part comprises at its lower end a spout 2 which is closed with a lid 9.
F ig. 8 shows a cross section through a syringe according to the invention in a second step in the filling process. In the second stage, the syringe is sterilized by heating and the contents of both storage compartments strive to expand due to the increased pressures. The pressure increases give rise to forces which are illustrated in the arrows in the ﬁ gures. The pressure increase in the upper storage space gives rise to a force on the first and second bellows 16a-b and ﬁ guren illustrates how these have been compressed to compensate for the pressure increase. The syringe is closed at its lower end with the expandable plug 18 and the third bellows 16c has expanded to compensate for the increase in pressure in the lower storage space.
F ig. 9 shows a cross section through a syringe according to the invention in a third step in the filling process when drying of the substance in the lower storage space is in progress. During dry drying, the pressure difference between the two storage spaces of the syringe changes and in addition the water in the upper storage space can freeze and expand.
F ig. 11 shows in greater detail the upper piston of the syringe with the first and second bellows compressed in this step to compensate for liquid in the upper storage space ﬁ usit and expanded. The expansion of the liquid and the compression of the bellows are indicated by the two lower arrows in the ﬁ gure.
In the lower opening of the cylindrical container 1, in this step a mouth part 8 is mounted instead of the expandable plug 18 and ﬁ g. 10 shows in greater detail the mouth of the syringe in this step. The lower storage space is here filled with active substance in solution which is freeze-dried by applying vacuum to the syringe. In order to allow evaporated solvent to leave the lower storage space, there is a discharge channel between the mouth part 8 and the lower opening of the cylindrical container 1, through which steam can pass, as indicated by the arrow in the clock.
After this step, the syringe is filled, sterilized, the dry substance is freeze-dried and the syringe is ready for storage for later use.
I ﬁ g. 12, a user has started using the syringe and the syringe is displayed when mixing of the substances in the chambers is in progress. The two piston rods have been locked apart with the lock 15 and the inner piston rod 13 has been pulled upwards from its position when storing the syringe. The upper piston is then forced upwards relative to its position when storing the syringe and liquid from the upper storage space is forced past the upper piston and into the lower storage space as indicated by the arrows in the clock.
Fig. 13 shows in greater detail the lower piston of the syringe, where the outer part of the sealing ring 7b has swung away downwards and towards its center, so that liquid can pass from above and downwards. The figure illustrates the still lyophilized substance as element 19 while the liquid from the upper storage space is dashed.
F ig. 14 shows the upper end of the syringe with the locking device, here in the unlocked position so that the two pistons can move relative to each other.
F ig. 15 shows the syringe when the substances in the chambers have been completely mixed and the lower piston has reached the upper one. In this position, the two pistons are locked together with a piston lock that is more clearly illustrated in ﬁ g. 16. The purpose of the piston lock is for the user to be able to press only the grip 14 of the inner piston rod and still push the two pistons together towards the mouth. In this position, the upper surface of the lower piston is immediately adjacent to the lower surface of the upper piston and only very little liquid from the upper storage space remains between the pistons which have not been mixed with the active substance.
F ig. 16 shows in greater detail the upper piston of the syringe with bellows after mixing, when the two pistons are locked together. The upper piston 7a comprises a cylindrical opening which is directed downwards and can receive the lower piston. The lower piston 5b comprises a comparatively rigid, cylindrical plate with fixed knobs 20 which are inserted into the sealing ring "fb and hold this read against the underside of the cylindrical plate. the plate projects around its periphery into a corresponding receiving groove on the inner surface of the cylindrical opening. The interaction between the cylindrical plate and the receiving groove is what locks the two pistons together.
Fig. 17 shows the syringe during exhalation of mixed substance and the piston pair is now pushed downwards.
The sealing ring 7b on the lower piston is designed to resist the passage of liquid down and up the river, which also means that it resists or counteracts movement of the sealing ring in the downward direction it is now moving. This is avoided with a design detail that is more clearly illustrated in ﬁ g. 18.
Fig. 18 shows in greater detail part of the upper piston of the syringe with one bellows. When, as here, the cylindrical plate is received in the receiving groove of the cylindrical opening in the upper piston, the outer portion of the sealing ring reaches the lower end of the upper piston. The lower end of the upper piston extends around the inner surface of the cylindrical container 1 and in this position forces the outer part of the sealing ring to fold slightly downwards and thereby bend away from the inner surface of the cylindrical container 1. In this way the sealing ring no longer abuts against the inner surface of the cylindrical container 1 and the piston pair slides easily downwards for discharging mixed substances. In the. Gure, the sealing ring and the lower end of the upper piston are illustrated as overlapping, but this is only to illustrate why the sealing ring bends away. Fig. 19 shows a cassette in a first assembly, filling and sterilization step. In the illustrated embodiment of the cassette, it is intended for all these three treatment steps, but the cassette can of course be used for only one or some of these three treatment steps.
The cassette comprises a first planar, square bottom plate 21 with 10x10 projecting cylindrical stop elements 23, each with a filling channel 24 which extends centrally in the axial direction of the stop elements. The cylindrical stop elements 23 are evenly distributed in a grid over the upper edge of the first bottom plate.
On top of the first bottom plate is a first receiving plate 22 which is square and provided with a set of 10x10 cylindrical through holes 24, evenly distributed over the square surface and arranged in a manner corresponding to the cylindrical stop elements 23.
The through holes have an inner diameter corresponding to the outer diameter of the cylindrical container 1 of the syringe, while the cylindrical stop elements 23 have an outer diameter corresponding to the inner diameter of the cylindrical container 1 of the syringe.
Cylindrical syringe containers 1, typically in the form of glass tubes, have been pushed down into all the cylindrical through holes and these extend down to the upper surface of the first bottom plate 21. The cylindrical containers 1 are thus clamped between the cylindrical stop elements 23 and the through-cylindrical holes 24.
In the cylindrical containers 1, the lower piston Sh with the inner piston rod 13 has been pushed down so far that the lower piston 5b reaches the cylindrical stop element 23. In this position the upper storage spaces are filled with liquid.
F ig. 20 shows the cassette in a second assembly, filling and sterilization step, where the upper pistons 5a with the outer piston rods 12 are pushed down into the cylindrical containers 1. The inner and outer piston rods are automatically locked together with the lock. On top of the first receiving plate 22 a second receiving plate 25 has been laid there which also receives the portions of the piston rods 12, 13 projecting from the cylindrical containers 1. The second receiving plate 25 is thus provided with a set of 10x10 non-through holes arranged in the same way as the through the holes 24 in the first receiving plate 22 and the stop elements 23 on the first bottom plate 21.
On the upper surface of the second receiving plate 25 there is a set of blow-out holes 26 which connect the 11 non-through holes to the surroundings and thus communicate with the channels 17 a-b in the syringe for pressure equalization.
Fig. 21 shows the cassette turned upside down in a third assembly, filling and sterilizing step. In this step, the first bottom plate 21, now at the top of the figure, has been lifted away so that the lower storage space is in contact with the surroundings.
Fig. 22 shows the cassette turned upside down in a fourth mounting, filling and sterilizing step where the first receiving plate 22 is removed and the cylindrical containers 1 are exposed to the viewer. The syringe is now held only in the second receiving plate 25 with the portions of the piston rods 12, 13 projecting from the cylindrical containers 1.
On the open ends of the cylindrical containers 1 which are directed upwards in the groove a second plane has been laid, square bottom plate 27a which thus in this position lies at the top of the groove, but since it is placed relative to other objects in the same way as the first bottom plate 21, this is also called the bottom plate. The second base plate 27a also has a series of fastening elements 28 arranged in a manner corresponding to the stop elements 23. These 10x10 fastening elements 28 are intended to receive 100 pre-assembled orifice parts 8. The second base plate 27 is placed directly over the second receiving plate 25 so that all the orifice parts 8 pushed down on the open ends of the cylindrical containers 1.
Fig. 23 shows a first variant of the second base plate 27b which, instead of being adapted to receive and hold in position pre-assembled orifice parts, is provided with 10x10 pre-assembled circular rubber discs 29 with a normally sealing through hole which connects to a corresponding hole. In the second base plate 27b, so that pressure equalization can take place. In an alternative embodiment not illustrated, the second base plate 27a-b may be adapted to be pre-assembled with 10x10 expandable plugs 18. Fig. 24 shows a detail in the first variant of the cassette where the rubber discs 29 and the holes 30 in the second base plate 27b are more clearly illustrated.
F ig. 25 shows a second variant of the second base plate 27c which substantially corresponds to the first variant, but comprises side pieces 31a-b which extend beyond the four sides of the base plate, of which only two are visible in the uren shape. Fig. 26 shows a detail in the second variant of the second base plate 270 where one of the rubber discs 29 which normally seals the open ends of the cylindrical containers 1 is shown and it can also be seen how the hole in the rubber disc is connected to corresponding holes in the second base plate 270.
In the second variant, however, there is a cavity 31 between the rubber disc 29 and the hole in the second bottom plate 270. The cavity allows the rubber disc to sag upwards when the pressure in the lower storage space, illustrated here at the top of the figure, increases. When the rubber disc fails, the hole in the rubber disc opens and the pressure equalizes.
Regardless of whether the second base plate 27a is illustrated in ﬁ g. 22, the first variant on the second base plate 27b or the second variant on the second base plate 270 is used, both storage spaces in each of the 100 syringes mounted in the cassette can be heat sterilized with the syringes arranged in the cassette as shown in the fourth step. in the use of the cassette.
F ig. 27 shows a cassette in a first mounting step where the cylindrical containers and the lower pistons with inner piston rods are pushed down into a first receiving plate 22. The inner piston rods 13 are here ready to receive the upper pistons 5a with the outer piston rods 12, followed by the locking elements 15 and finally the grips 14. F ig. 28 shows in more detail the cassette in the first mounting step with the inner piston rods 13.
F ig. 29 shows the upper piston and the outer piston rod separately. The figure is not illustrated in cross-section, so the bellows are not visible. F ig. 30 shows separately the grip 14 for the inner piston rod and ﬁ g. 31 shows separately the locking element 15 for the inner piston rod.
The described embodiments of the syringe show two-chamber syringes, but the invention can of course also be applied to single-chamber or single-chamber syringes and the number of expandable elements 16a-b may then be adapted to the number of chambers. For expandable syringe syringes, the expandable elements can be in direct communication with the syringe environment directly or indirectly. indirect kommunikation uid communication with the environment of the syringe means that expansion in a first expandable element forces a second expandable element connected to it with a ﬂ uid to expand, which in turn is in direct ﬂ uid communication with the environment of the syringe. The number of such expandable elements connected to a ﬂ can of course be increased indefinitely in a corresponding manner. The fact that an expandable element is in unspecified communication with the environment of the syringe means in the requirements that this communication is direct or indirect. 13

权利要求:
Claims (8)
[1]
Claim 1 A syringe comprising a cylindrical container (1) in which at least one first piston (5, 5a-b) delimits at least one storage space, characterized! in that the syringe is provided with at least one expandable element (l6a ~ b) which tightly delimits the storage space and is in ﬂ uid communication between the storage space and the environment of the syringe.
[2]
A syringe according to claim 1, characterized in that the expandable element (16a-b) dr resiliently strives to return to an unloaded position.
[3]
A syringe according to claim 2, characterized in that the expandable element (16a-b) consists of a bellows.
[4]
A syringe according to claim 1 or 2, characterized in! in that the expandable element (16a ~ b) is arranged on a first piston (5, Sa-b).
[5]
A syringe according to any one of the preceding claims, characterized in that the expandable element (16a-b) is in fluid communication between the storage space and the environment of the syringe via a channel (17a-b) in a first piston (5, 5a-b) .
[6]
A syringe according to any one of the preceding claims, characterized in that the syringe comprises a first (Sa) piston with a first piston rod (12) and a second piston (5b) with a second piston rod (13), wherein the first piston rod ( 12) and the second piston rod (12) can be locked against each other with a locking element (15).
[7]
A syringe according to claim 6, characterized in that the second piston (5b) is provided with a sealing element (7b) which is sealing unloaded, under load escapes fluid in a first direction but under load does not escape fluids in a second direction .
[8]
A syringe according to any one of the preceding claims, characterized in that the syringe is provided with piston rods (12, 13) extending from the cylindrical container (1) in a first direction and where the syringe at the end facing in the opposite direction can receive a lid with an expandable element (l6c). A cassette is for mounting, filling and sterilizing a syringe comprising a cylindrical container (1) in which runs at least a first piston (5, Sa-b) delimiting at least one storage space, the syringe being provided with at least one expandable element ( 16a-b) which tightly delimit the storage space and are in ﬂ uid communication between the storage space and the environment of the syringe, characterized in that the cassette comprises receiving plates (21, 22, 25, 27 ac), where at least one of the receiving plates comprises openings (24) for receiving such syringes and wherein at least one of the receiving plates comprises openings (26, 30) which can be placed in communication with at least one expandable element (lóa-b) in at least one syringe. 15

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同族专利:

公开号 | 公开日

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AU2015399329B2|2015-06-19|2021-09-23|Janssen Pharmaceutica Nv|Devices and methods for drug administration and mixing, and training of proper techniques therefor|

US10286151B2|2016-02-26|2019-05-14|West Pharma. Services IL, Ltd.|Plunger with reduced leakage during storage|

EP3254717A1|2016-06-09|2017-12-13|Novartis Ag|Syringe and method for dispensing a liquid|

法律状态:
2014-01-02| NUG| Patent has lapsed|

优先权:

申请号 | 申请日 | 专利标题

SE1000466A|SE535417C2|2010-05-06|2010-05-06|Syringe with expandable element|SE1000466A| SE535417C2|2010-05-06|2010-05-06|Syringe with expandable element|

PCT/SE2011/000076| WO2011139198A1|2010-05-06|2011-05-02|Syringe with yielding element|

US13/696,467| US20130060203A1|2010-05-06|2011-05-02|Syringe with yielding element|

AU2011249084A| AU2011249084A1|2010-05-06|2011-05-02|Syringe with yielding element|

EP11777640A| EP2566540A1|2010-05-06|2011-05-02|Syringe with yielding element|

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