• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Device for dispensing a fluid product synchronized with inhalation, comprising a body (10; 10 ') provided with a mouthpiece (400), a product reservoir (100) containing a fluid and a propellant being mounted axially sliding in said body (10; 10 '), a metering valve (200) having a valve (210) being assembled on said reservoir (100) for selectively dispensing the fluid, comprising: - an actuating element (500, 500' , 500 "; 550) movable and / or deformable between a non-actuating position, in which said metering valve (200) can not be actuated, and an actuating position, in which said metering valve (200) can be actuated an inhalation-activated triggering system comprising an inhalation sensitive member (60, 61; 65, 66) which is deformable and / or displaceable by inhalation, said inhalable responsive member (60, 61, 65, 66), when it deforms e and / or moves, displacing and / or deforming said actuating element (500, 500 ', 500 "; 550) from its non-actuating position to its actuating position, - an electronic dose counter (1000), and - signal transmission means (1100) for remote communication including information relating to the actuations of the device.
    公开号:FR3050116A1
    申请号:FR1653375
    申请日:2016-04-15
    公开日:2017-10-20
    发明作者:Guillaume Brouet；Ludovic Petit
    申请人:Aptar France SAS；
    IPC主号:
    专利说明:

    The present invention relates to a fluid dispensing device synchronized with inhalation, and more particularly to an inhalation device of the aerosol type synchronized with the inhalation.
    Inhaling devices generally referred to as B.A.I. (meaning "Breath Actuated Inhaler"), are well known in the state of the art. The main advantage of this type of device is that the distribution of the product is synchronized with the inhalation of the patient, to ensure a good distribution of the product in the airways. Thus, in the field of aerosol devices, that is to say those in which the product is distributed using a propellant, many types of devices for triggering by inhalation have been proposed. However, these devices have the disadvantage of having a large number of parts, that is to say, they are complicated and expensive to manufacture and assemble, which is obviously disadvantageous. It is also difficult to find the right balance between reliable triggering at each inhalation, without the triggering threshold being too high, and a lock robust enough to prevent accidental or unwanted actuation. However, if the lock unlocks accidentally, the device is operated automatically and the dose is distributed, even if the user did not want it.
    Thus, more than the automatic actuation of the device, what is important to obtain a good distribution of the dose is to achieve this distribution in a manner synchronized with the inhalation of the user, even if the actuation or triggering itself remains manual.
    The object of the present invention is to provide a fluid dispensing device synchronized with the inhalation which does not reproduce the aforementioned drawbacks.
    It is another object of the present invention to provide a fluid delivery device synchronized with inhalation which improves operating reliability, ensuring effective actuation with each inhalation.
    The present invention also aims to provide a fluid dispenser device synchronized with the inhalation which minimizes the risk of accidental or unwanted actuation.
    It is another object of the present invention to provide a fluid delivery device synchronized with the inhalation which does not have an excessively high triggering threshold, thus enabling relatively weak persons, such as sick or elderly persons, to use the device safely and reliably.
    The present invention also aims to provide a device for dispensing fluid synchronized with inhalation that is simple and inexpensive to manufacture and assemble.
    The subject of the present invention is therefore a fluid dispensing device synchronized with inhalation, comprising a body provided with a mouthpiece, a product reservoir containing a fluid product and a propellant gas being mounted axially sliding in said body, a metering valve comprising a valve being assembled on said reservoir for selectively dispensing the fluid, said device comprising: an actuating element displaceable and / or deformable between a non-actuating position, in which said metering valve can not be actuated, and an actuating position, in which said metering valve can be actuated, - an inhalation controlled triggering system comprising an inhaled, deformable and / or movable member under inhalation, said organ responsive to inhalation, when it deforms and / or moves, displacing and / or deforming said element of actuating its non-actuating position towards its actuated position, - an electronic dose counter, and - signal transmission means for remote communication including information relating to the actuations of the device.
    Advantageously, said actuating element is a locking element which, in the non-actuating position, cooperates on the one hand with the body and on the other with the reservoir to prevent axial displacement of said reservoir in the body.
    Advantageously, the device comprises a trigger element displaceable and / or deformable between a locking position, in which it blocks said locking element in its locking position, and a release position, in which it does not block said locking element.
    Advantageously, said triggering system controlled by inhalation comprises a deformable membrane defining a deformable air chamber, said deformable membrane being fixed to said trigger element, said deformable membrane being deformed during inhalation so that it displaces said triggering element from its blocking position to its release position.
    Advantageously, said trigger element is manually accessible by the user so that it can be moved manually towards its release position even in the absence of inhalation.
    Advantageously, an actuating member is assembled on the reservoir on the side axially opposite to said metering valve, said actuating member comprising a hollow sleeve axially movable relative to said reservoir between a rest position and a loaded position, a spring being disposed between the bottom of the tank and the closed upper edge of said hollow sleeve, so that when the user manually presses said actuating member to move it to its loaded position, said spring is compressed to transmit an axial force F to said reservoir .
    Advantageously, a lateral actuating handle is pivotally mounted on the body between a rest position and a position of use in which it axially displaces said actuating member (800) in its loaded position.
    Advantageously, said body comprises an opening connecting the mouthpiece with the inside of the body, said opening being closed at the beginning of inhalation by a valve, so that the inhalation flow is initially mainly transmitted to the triggering system by the valve. 'inhalation.
    Advantageously, said valve is open when said blocking element moves towards its actuating position.
    Advantageously, which said locking element comprises an axial extension of which a lower end is fixed radially and axially with respect to said body and an upper end cooperates with said reservoir in the non-operating position.
    Advantageously, said triggering system controlled by inhalation comprises a sliding piston in a chamber between a rest position and an inhalation position.
    Advantageously, said locking element is assembled on a rod integral with the piston, so that during inhalation, said rod moves radially deforming and / or moving said axial extension to its actuating position.
    Advantageously, said actuating element is a locking element which, in the non-actuating position, allows the axial displacement of said metering valve valve together with said reservoir in the body, preventing the actuation of said metering valve when said reservoir is moved axially in the body without inhalation.
    Advantageously, during inhalation, said locking element is moved and / or deformed so that it blocks the axial displacement of the valve relative to the body.
    Advantageously, said triggering system controlled by inhalation comprises a sliding piston in a chamber between a rest position and an inhalation position.
    Advantageously, said locking element is integral with a rod integral with the piston, so that during inhalation, said rod moves radially moving said locking member towards its actuating position in which it prevents the axial displacement of said valve of the metering valve when said reservoir is moved axially in the body.
    These and other features and advantages will appear more clearly in the following detailed description, made with reference to the accompanying drawings, given as non-limiting examples, and in which: FIG. 1 is a diagrammatic view in section of FIG. a fluid dispenser device, according to a first advantageous embodiment, in the rest position, - Figure 2 is a schematic sectional view of a fluid dispenser device, according to another advantageous embodiment, in the rest position, - Figure 3 is a view similar to that of Figure 2, when the user attempts to operate the device without inhalation, - Figure 4 is a view similar to that of Figure 3, when the user actuates the device with simultaneous inhalation; - Figure 5 is a diagrammatic cut-away view of a fluid dispensing device, according to yet another advantageous embodiment, in position of rest, - Figure 6 is a view similar to that of Figure 5, in the dispensing position, and - Figure 7 is a view similar to that of Figure 5, illustrating an alternative embodiment, - Figure 8 is a diagrammatic sectional view of a fluid dispensing device, according to yet another advantageous embodiment, in the rest position, - Figure 9 is a view similar to that of Figure 8, after actuation, and - FIG. 10 is an exploded perspective view of the device of FIGS. 8 and 9.
    In the description, the terms "upper", "lower", "high" and "low" refer to the position of the device shown in particular in FIG. 1. The terms "axial" and "radial" refer to the axis vertical central A shown in particular in Figure 1. The terms "proximal" and "distal" refer to the mouthpiece. The invention is more particularly applicable to aerosol valve type inhalation devices for oral delivery, as will be described in more detail below, but it could also be applicable to other types of devices. inhalation, for example of the nasal type.
    The figures represent several advantageous embodiments of the invention, but it is understood that one or more of the component parts described below may be performed differently while providing similar or even identical functions.
    With reference to the drawings, the device comprises a main body 10 provided with a mouthpiece 400. This mouthpiece 400 defines a dispensing orifice through which the user will inhale during use of the device. The mouthpiece 400 can be made in one piece with the body 10, as in Figures 1 to 7, or be formed on a lower body portion 10 'which is fixed to said main body 10, as in Figures 8 to 10. A removable protective cover 410 may be provided on said mouthpiece 400, especially during storage periods, that the user will remove before use. Figure 1 shows such a protective cover, which could be of any shape.
    The main body 10 contains a reservoir 100, containing the product to be dispensed and a propellant, such as an HFA-type gas, a metering valve 200 being mounted on said reservoir 100 to selectively dispense the product. The metering valve 200 comprises a valve body 201 and a valve 210 axially displaceable upon actuation with respect to said valve body 201, and thus with respect to said tank 100. This metering valve 200 may be of any suitable type. It can be fixed to the reservoir 100 by a fixing element, preferably a crimped capsule 5, preferably with the interposition of a neck seal 4.
    Advantageously, during actuation, the valve 210 is fixed relative to the body 10, and it is the reservoir 100 which is displaced axially relative to the body 10 between a distal position, which is the rest position, and a position proximal. The outlet port of the valve 210 of said metering valve 200 is connected via a channel 300 to said mouthpiece 400, through which the user inhales the dispensed product. In known manner, said valve 210 is received in a valve well 700 which at least partially defines said channel 300. In the embodiments of FIGS. 1 and 8 to 10, the valve well 700 is formed in one piece with the body 10 or the lower part of body 10 ', whereas in the embodiments of FIGS. 2 to 7, said valve well 700 is axially displaceable with respect to said body 10.
    According to the invention, the device comprises an actuating element 500, 500 ', 500 ", 550 displaceable and / or deformable between a non-actuating position, in which said metering valve 200 can not be actuated, and a position of actuation, in which said metering valve 200 can be actuated In the rest position, said actuating element 500, 500 ', 500 ", 550 is in the non-actuating position, and this is the inhalation of the user through the mouthpiece 400 which moves and / or deforms said actuating element 500, 500 ', 500 ", 550 to its actuating position, in other words, as long as the user has not inhaled , the actuation of the metering valve 200 is impossible, and it is only when it inhales that it can actuate said metering valve 200, preferably by manual support on the bottom of the tank 100.
    As will be described in more detail below, the actuating element may be a locking element 500, 500 ', 500 "which, in the non-actuating position, prevents axial displacement of the reservoir 100 in the body 10. During inhalation, this locking element 500, 500 ', 500 "is displaced and / or deformed so that it no longer blocks the axial displacement of the reservoir 100 in the body 10. Thus, after inhalation, such axial displacement of the reservoir 100 causes the actuation of the metering valve 200 and the distribution of a product dose synchronized with this inhalation.
    In a variant, as will be described with reference to FIGS. 2 to 4, the actuating element may be a locking element 550 which, in the non-actuating position, allows axial displacement of the valve 210 of the metering valve 200 together. with reservoir 100 in the body 10, thereby preventing the actuation of said metering valve 200 when said reservoir 100 is moved axially in the body 10 without inhalation. Upon inhalation, this locking member 550 is moved and / or deformed such that it blocks the axial displacement of the valve 210 relative to the body 10. Thus, after inhalation, an axial displacement of the reservoir 100 causes the actuating the metering valve 200 and dispensing a dose of product synchronized with this inhalation.
    Thus, in the various variants described above, in the absence of inhalation, there is no risk that a dose of active product is lost by an unfortunate or incomplete operation in which the user would not exercise inhalation. The actuation of the valve 200 and the expulsion of a dose of fluid product are therefore possible only if the user inhales and simultaneously presses the reservoir 100 to actuate the valve 200.
    The device comprises a triggering system controlled by inhalation of the user, which is intended to move and / or deform said actuating element 500, 500 ', 500 ", 550 from its non-actuating position to its position d actuation, when the user inhales through the mouthpiece 400.
    This trigger system comprises an inhalation sensitive member 60, 61, 65, 66 deformable and / or displaceable under the effect of inhalation, this inhalation-sensitive member 60, 61, 65, 66 being adapted, when it deforms and / or moves, to move and / or deform said actuating element 500, 500 ', 500 ", 550 from its non-operating position to its actuating position.
    As will be described in more detail below, the organ sensitive to inhalation can be made in the form of a deformable membrane 61 defining a deformable air chamber 60, for example a bellows or a deformable bag.
    Alternatively, as will be described with reference to FIGS. 2 to 7, the organ sensitive to inhalation may be in the form of a piston 65, preferably cylindrical, sliding in a chamber 66, preferably cylindrical, not deformable.
    According to the invention, the device embeds electronic modules.
    In particular, an electronic dose counter 1000 is provided. This counter 1000 can notably detect the movements of the reservoir 100, for example by means of a contact sensor 1010. As a variant, the counter 1000 could be connected to a sensor, in particular a membrane sensor, which detects the distribution of the dose of fluid, for example in the valve well 700. Other means of actuating the electronic counter 1000 are also possible, for example the detection of the displacement of the valve 210 of the metering valve relative to the valve body 201.
    The device also comprises signal transmission means 1100 for remote communication including information relating to the actuations of the device. In particular, the body 10 may comprise a signal transmission module for remote communication with any base. Suitable feeding means are advantageously provided.
    Advantageously, the electronic module may comprise in particular a card comprising an electrical switch which sends a pulse. The module may also include a display and / or use a Bluetooth or Wifi connection to send the information to a peripheral device. Suitable sensors may be provided, such as flow rate and / or pressure sensors, to detect various parameters of the inhalation flow.
    Associated with a dose counter 1000 which counts each dose actually emitted and the synchronization device with the inhalation of the invention, these signal emitting means 1100 make it possible to transmit in an absolutely reliable manner each dose distribution, for example to a physician or other person wishing to monitor the use of the inhalation device by the user. The synchronization device with inhalation ensures that the user inhales each time he actuates the device, and the meter records each dose dispensed, as well as various associated parameters, such as the timestamp of each distribution and the characteristics of the device. inhalation. The doctor can thus know exactly the conditions of use of the device by the user.
    According to a first embodiment, represented in FIG. 1, the non-actuating position corresponds to a blocking position of the reservoir 100 in the body 10. In this blocking position, the reservoir 100 is prevented from moving by said element actuation, which will be released only at the moment of inhalation. The actuating element, forming a blocking element, is here advantageously formed by a locking ring 500, comprising at least one, preferably three axial locking tabs 501, which are elastically deformable radially outwardly. This locking ring 500 is fixed, in particular latched, on the reservoir 100, in particular on the capsule 5 which fixes the metering valve 200 on the reservoir 100. The said locking tabs 501 rest in the rest position on a radial shoulder 710 of the valve well 700. This shoulder is preferably inclined downwards and radially outwards, so that when the reservoir 100 slides axially in the body 10 during actuation, said axial locking tabs 501 slide on said shoulder 710 inclined, which deforms them radially outwards.
    A trigger element 600 is mounted to slide axially around said valve well 700 between a locking position, in which it blocks said locking ring 500 in its non-actuating position, and a release position, in which it no longer blocks said ring. In particular, in the embodiment of FIG. 1, said trigger element 600, in the locked position, cooperates with said locking tabs 501, preventing any radial outward deformation of said locking lugs 501. when said trigger element 600 is in the locking position, it prevents radial outward deformation of said locking tabs 501, which consequently remain axially locked by said shoulder 710 of the valve well 700, which blocks the axial displacement of the reservoir 100 and therefore the actuation of the metering valve 200. Optionally, sliding means, such as balls, may t be interposed between the valve well 700 and the trigger element 600, to facilitate the sliding of the latter during inhalation. The trigger element 600 advantageously comprises a hollow central sleeve 650 which slides axially around the valve well 700. Two axial lugs (not shown), diametrically opposite, and each connected to said central sleeve 650 may be provided to cooperate each with a respective opening of the body 10, to substantially close these openings in the locking position, and to substantially open these openings in the release position. These openings being closed at the beginning of inhalation, the inhalation flow is initially mainly transmitted to the triggering system by inhalation, in this example the deformable air chamber 60. This makes it possible to optimize this triggering by inhalation. . When the trigger element 600 has moved axially towards its release position under the effect of inhalation, and therefore when the user can actuate the metering valve 200 to dispense a dose of fluid product, the axial tabs open said openings of the body 10, which generates a call for air, and thus increases the flow of inhalation. This optimizes the synchronization between the dose distribution and the user's inhalation, and promotes a good distribution of the dose in the lungs of the user.
    Advantageously, said axial tabs can be accessible from the outside through said openings. This makes it possible, in case of necessity, to manually move the trigger element 600 so as to be able to actuate the metering valve 200 even without inhalation, for example if the person to receive the dose of fluid product is incapable of producing a sufficient inhalation. It is therefore a security. As a variant for this security, it would be possible to provide an axial extension (not shown) integral with the trigger element 600, extending for example laterally from the tank 100, and accessible by the user from outside the body 10.
    Alternatively, the trigger member 600 may not include the axial lugs, and the body may not have the openings 13. In this case, the inhalation flow may flow axially into the body 10, around the well. valve 700, which could be favored by a central sleeve 650 provided with axial cuts allowing passage of the air flow.
    In the embodiment of FIG. 1, the organ sensitive to inhalation is in the form of a deformable air chamber 60. Advantageously, this air chamber comprises a deformable membrane 61 which is connected to one part to the body 10 and the other to said trigger element 600. Advantageously, a membrane sleeve 900 is fixedly disposed in the body 10, with a lower shoulder 910 which wedges a first edge 62 of the membrane 61 against a portion 17 of the body 10. The second edge 63 of the membrane 61 can be fixed in a groove 630 of the trigger element 600, advantageously formed on the hollow central sleeve 650 thereof.
    Upon inhalation, the deformable membrane 61 deforms and / or contracts under the effect of the depression generated by inhalation, causing the trigger 600 to move from its blocking position to its release position. This then allows the radial deformation of said locking tabs 501 and thus the displacement of said locking ring 500 forming the actuating element from its non-actuating position to its actuating position. Figure 1 shows a deformable membrane 61 made in the form of a pocket or a diaphragm. Of course, other forms are also conceivable, for example a bellows as shown in Figures 8 to 10.
    The valve 200 is therefore actuated at the time of inhalation, so that the fluid dose is expelled out of the dispensing orifice simultaneously with the inhalation. The dose distribution is counted by the counter 1000, and the information relating to the taking of dose, such as, for example, the time stamp and the parameters of the inhalation flow, are transmitted by the emitting means 1100.
    When the user wishes to use the device, he places the mouthpiece 400 in his mouth, and manually presses on the bottom of the tank 100, that is to say the upper surface of said reservoir 100 in the position of Figure 1 The reservoir 100 will then be blocked and prevented from sliding in the body 10 by the locking tabs 501 of the locking ring 500, which rest on the shoulder 710 of the valve well 700. Optionally, the reservoir 100 can perform a small race before being blocked, this small initial race being however insufficient to actuate the metering valve 200.
    When the user inhales through the mouthpiece 400, he will deform the deformable membrane 61, which will slide the trigger element 600 attached to said deformable membrane 61. This displacement of the trigger element 600 on the well of valve 700 will radially release the tabs 501 of the locking ring 500. Under the effect of the axial force transmitted by the reservoir 100, generated by the user pressing against the bottom of said tank 100, the axial tabs 501 will be able to radially outwardly deform, and thus pass over said shoulder 710, to allow the sliding of the reservoir 100 to its dispensing position, and thus the actuation of the valve 200.
    At the end of inhalation, the trigger element 600 is brought upwards by the elasticity of the membrane 61.
    When the user releases its pressure on the bottom of the tank 100, it returns towards the rest position under the effect of the return spring of the valve 200, and simultaneously the valve 210 of the metering valve returns to position resting, loading a new dose of fluid into the valve chamber. The device is then ready for another use.
    Figures 2 to 4 illustrate another embodiment of the invention. Here, the actuating element is a locking element 550 which, in the non-actuating position, allows the axial displacement of the valve 210 of the metering valve 200 together with the reservoir 100 in the body 10, preventing the actuation of said metering valve 200 when said reservoir 100 is axially displaced in the body 10 without inhalation. Upon inhalation, this locking member 550 is moved and / or deformed such that it blocks the axial displacement of the valve 210 relative to the body 10. Thus, after inhalation, an axial displacement of the reservoir 100 causes the actuating the metering valve 200 and dispensing a dose of product synchronized with this inhalation. The organ sensitive to inhalation is in the form of a piston 65 sliding in a chamber 66 between a rest position and an inhalation position. The chamber 66 is advantageously formed in the mouthpiece 400. Said piston 65 is connected to said locking element 550, advantageously by a rod 540. In particular, as can be seen in FIGS. 2 to 4, the locking element 550 can be formed at the end of said rod 540 opposite said piston 65, and comprises an axial projection 551. A spring 67, advantageously disposed in the chamber 66, is adapted to return said piston 65 towards its rest position when there has more inhalation through the mouthpiece 400.
    In the non-actuating position, said projection is offset radially with respect to the valve well 700, so that it can move axially in the body 10, together with the valve 210 of the metering valve 200 and the reservoir 100. Thus in this non-actuating position, the valve 210 moves relative to the reservoir 100, and the metering valve 200 is not actuated.
    When the user inhales through the mouthpiece 400, the piston 65 moves radially (relative to the displacement axis of the reservoir 100 in the body 10) in the chamber 66 under the effect of the depression created by inhalation. Projection 551 thus also moves radially, and is positioned under said valve well 700, thereby forming an abutment to axial downward movement of said valve well. Therefore, the pressure exerted by the user on the bottom of the tank 100 will move it axially downwards in the body, and the valve well 700, now axially fixed relative to the body 10, will therefore block the valve 210 of the metering valve axially relative to the body 10, so that it will sink into the valve body, thereby causing the actuation of the metering valve 200 and the dispensing of a dose of fluid.
    Of course, in this embodiment where the reservoir 100 is axially displaceable in the body 10 both in the actuating position and the non-actuating position of the actuating element 550, the dose counter 1000 can not measure this displacement. In this case, preference will be given to sensors detecting the distribution of the fluid product, in particular in the valve well 700, or sensors detecting the displacement of the valve 210 of the metering valve 200 with respect to the valve body 201.
    Figures 5 to 7 illustrate yet another embodiment. Here, the triggering system by inhalation is similar to that described above with reference to Figures 2 to 4, with a piston 65 sliding radially in a chamber 66 of the mouthpiece 400.
    Here, the actuating element is again made in the form of a locking element 500 ', which, in the non-actuating position, prevents the axial displacement of the reservoir 100 in the body 10. During inhalation, this locking element 500 'is displaced and / or deformed so that it no longer blocks the axial displacement of the reservoir 100 in the body 10. Thus, after inhalation, such axial displacement of the reservoir 100 causes the actuation of the metering valve 200 and the distribution of a dose of product synchronized with this inhalation.
    This locking element 500 'can in particular be assembled on said rod 540 integral with the piston 65, and include an axial extension 505 which, in the non-actuating position extends axially in the body to cooperate with and axially lock said reservoir 100. When the user inhales, the rod 540 moves radially to the left (in the orientation of Figures 5 to 7), which will cause the deformation of said axial extension 505, and thus release the axial displacement of the tank 100. In the In the example shown, the valve well 700 is movably mounted in the body 10, but it could also be fixed.
    Advantageously, the lower end 506 of said axial extension 505 is fixed radially and axially relative to the body 10. Thus, when the rod 540 moves radially, it pulls radially on said axial extension, which deforms, for example bends or rotates, so that the upper end disengages the tank 100 and releases it for its axial displacement. Of course, the blocking element 500 'could have any other suitable form. In particular, one can consider the use of an articulated toggle.
    FIG. 7 represents an alternative embodiment in which the rod 540 is accessible from the outside of the body 10 through an opening 19 of said body 10. This makes it possible, if necessary, to manually move the locking element 500 ', in order to to be able to actuate the metering valve 200 even without inhalation, for example if the person to receive the dose of fluid product is unable to achieve sufficient inhalation. It is therefore a security. It should be noted that this security could also be adapted to the embodiment of FIGS. 2 to 4.
    In the example of FIGS. 8 to 10, an actuating member 800 is assembled on the upper end of the tank 100, axially opposed to said metering valve 200. This actuating member 800 comprises a hollow sleeve 801 disposed in the body 10 around the reservoir 100, with a spring 850 disposed between the bottom of the reservoir 100 and the closed upper edge of said hollow sleeve 801. The hollow sleeve 801 is axially movable relative to said reservoir 100 between a rest position and a loaded position. Thus, when the user wishes to move the reservoir 100 axially in the body 10, to actuate the metering valve 200, he presses on said actuating member 800. This will axially move said hollow sleeve 801 to its loaded position and thus compress said 850 spring, which will thus transmit an axial force F to said tank 100 which is substantially the same on each actuation. As long as the user maintains his support on said actuator 800, said spring 850 is compressed and axially urges said reservoir 100 towards its actuating position.
    In the variant of Figures 8 to 10 a lateral actuating handle 20 is pivotally mounted on the body 10. This handle, when moved from its rest position, visible in Figure 8, to its position of use, visible on the FIG. 9 axially displaces said actuating member 800 to compress the spring 850. This can in particular be done by means of a cam on the handle 20 cooperating with a complementary profile on the actuating member 800. user maintains its support on said handle, said spring 850 is compressed and axially urges said reservoir 100 to its actuating position. Advantageously, said handle 20 comprises a biasing member which urges said handle 20 towards its rest position. Thus, when the user releases its pressure on the handle 20, it automatically returns to its rest position. This avoids the risk that after actuation of the metering valve 200, the latter remains in the actuated position, which could have the consequence that the valve chamber fills with air and that the next dose is incomplete or that the valve is leaking. This is one of the problems currently encountered by existing devices on the market.
    Of course, this handle 20 is not necessary, and also the actuator 800, the user can directly press the bottom of the tank, as in the embodiments described above. The actuation of the valve 200 and the expulsion of a dose of fluid product are therefore possible only if the user inhales and simultaneously it bears axially on the reservoir 100 to actuate the valve 200. As described above, this support axial on the tank 100 can be done through the actuating member 800 which compresses the spring 850. Alternatively, the user could directly press the bottom of the tank 100. In the variant of Figures 8 to 10 it is the handle 20 that will generate this axial support, also via the actuating member 800 in the example shown. Finally, one could also use an automatic actuation system, which would apply this axial support on the tank 100 independently of the user.
    In the embodiment of FIGS. 8 to 10, the actuating element is a locking element 500 "which, in the non-actuating position, prevents the axial displacement of the reservoir 100 in the body 10. The locking element 500 "is advantageously pivotally mounted about an axis B on the body 10 or on the body portion 10 'between a locking position and an actuating position. In the example shown, said axis B passes through a lower edge of said locking element 500. The locking element 500 "comprises at least one, preferably two locking extensions 501 ', which cooperate in the locking position with the reservoir 100 (advantageously with the crimping capsule 5). The locking element 500 "is held in the locking position by a trigger element 600 'This trigger element 600 is pivotally mounted about an axis C on the body 10, on the body part 10' or on the handle 20 between a locking position, in which it blocks said locking element 500 "in its locking position, and a release position, in which it no longer blocks said locking element 500". In the example shown, said axis C passes approximately in the middle of said element of said trigger 600 'Advantageously, the axes B and C are parallel The locking element 500 "and the trigger element 600' together define a lock. In particular, said trigger element 600 'comprises a locking shoulder which, in the locking position, cooperates with a projection of the locking element 500 ", preventing the pivoting of said locking element 500" from its locking position. Thus, when said trigger element 600 'is in the locking position, it prevents the displacement of the blocking element 500 "towards its actuating position, which blocks the axial displacement of the tank 100 and therefore the actuation of the valve metering machine 200.
    Thanks to this system of effort of the lock, the force required to rotate the trigger 600 'is very low and can be generated by the deformable membrane 61, which transforms the depression generated by the inhalation force unlocking.
    Advantageously, the lower body portion 10 'has an opening 13 connected to the interior of the body 10. This opening 13 is closed at rest and at the beginning of inhalation by a valve 14, so that the inhalation flow is initially mainly transmitted to the triggering system by inhalation, in this example the deformable air chamber 60. This optimizes this triggering by inhalation. When the locking element 500 "has moved to its actuated position under the effect of inhalation, and therefore when the user can actuate the metering valve 200 to dispense a dose of fluid product, said element of blocking 500 "moves said valve 14 to an open position. When said openings 13 are thus open, a call for air is generated, which increases the inhalation flow. This optimizes the synchronization between the dose distribution and the user's inhalation, and promotes a good distribution of the dose in the lungs of the user.
    Advantageously, the trigger element 600 'may be accessible from outside the body 10 and / or the lower body portion 10'. This makes it possible, in case of necessity, to manually move the trigger element 600 'so as to be able to actuate the metering valve 200 even without inhalation, for example if the person to receive the dose of fluid product is incapable of producing a sufficient inhalation. It is therefore a security.
    In the embodiment shown in FIGS. 8 to 10, the organ sensitive to inhalation is in the form of a deformable air chamber 60. Advantageously, this air chamber comprises a deformable membrane 61 which is connected on the one hand to said lower body portion 10 'and on the other hand to said trigger element 600'. Advantageously, as shown in the figures, the membrane 61 has a bellows shape and forms a substantially sealed chamber. Other forms are possible, including a simple pocket or diaphragm. A pad can fix said membrane 61 to an orifice of said trigger element 600 '.
    Upon inhalation, the deformable membrane 61 deforms and / or contracts under the effect of the depression generated by inhalation, causing the trigger 600 'to move from its locking position to its release position . This makes it possible to open the lock defined between the locking element 500 "and the trigger element 600 ', and thus the displacement of said locking element 500" from its blocking position to its actuated position.
    The valve 200 is therefore actuated at the time of inhalation, so that the fluid dose is expelled out of the dispensing orifice simultaneously with the inhalation.
    Advantageously, the actuating member 800 comprises a locking tab (not shown), which can cooperate in the rest position with said trigger element 600 ', to prevent it from moving towards its release position. Thus, if the user inhales without exerting axial support on the tank 100, the lock will not be unlocked, since the trigger 600 'can not rotate. The air chamber 60 being substantially sealed, and the valve 14 being closed on the opening 13, the user realizes very quickly that he can not inhale properly through the mouthpiece 400, which reminds him that it is first necessary to exert the axial support on the tank 100 before inhaling. When the user presses the actuating member 800, he moves the sleeve 801 axially relative to the reservoir 100, which is blocked by the blocking element 500, which compresses the spring 850. An inhalation will then cause a pivoting of the trigger element 600, and therefore the actuation of the device, as explained above.
    When the user wishes to use the device, he places the mouthpiece 400 in his mouth, and manually exerts an axial support on the bottom of the reservoir 100, that is to say the upper surface of said reservoir 100 in the position of the FIGS. The reservoir 100 is blocked and prevented from sliding axially in the body 10 by the blocking extensions 501 of the blocking element 500. At the same time, the blocking of the trigger element 600 'is suppressed by the axial displacement of the body actuator 800.
    When the user inhales through the mouthpiece 400, it will deform the deformable membrane 61, which will rotate the trigger element 600 'attached to said deformable membrane 61. This displacement of the trigger 600' will release the lock formed between the triggering element 600 'and the blocking element 500. Under the effect of the axial force transmitted by the reservoir 100, generated by the axial support on the bottom of said tank 100, the element blocking 500 "will pivot allowing the axial sliding of the tank 100 in the body 10 to its dispensing position, and therefore the actuation of the valve 200. In parallel, the blocking element 500" will open the valve 14. '.
    At the end of inhalation, when the user releases its pressure on the bottom of the tank 100, the latter goes up axially in the body towards its rest position under the effect of the return spring of the valve 200, and simultaneously the valve 210 of the metering valve returns to the rest position, loading a new dose of fluid into the valve chamber. The trigger element 600 'is returned to its initial position by the elasticity of the membrane 61 and / or by the actuating member 800 which returns to its rest position. The blocking element 500 "returns to its blocking position, advantageously via an elastic element, such as a spring or an elastomer element (not shown).
    The device is then ready for another use.
    In particular, the electronic dose counter 1000 can be assembled in the handle 20. This counter 1000 can notably detect the movements of the reservoir 100, for example by means of a slider 1010 'which is displaced by the reservoir 100 or by the In a variant, the counter 1000 could be connected to a sensor, in particular a membrane sensor, which detects the distribution of the dose of fluid product, for example in the other means of actuating the electronic counter 1000 are also possible, for example the detection of the displacement of the valve 210 of the metering valve relative to the valve body 201.
    Preferably, the device also comprises signal transmission means 1100 for remote communication including information relating to the actuations of the device. In particular, the body 10 and / or the handle 20 may comprise a signal transmission module, for remote communication with any base. Suitable feeding means are advantageously provided.
    In the example shown in Figures 8 to 10, the electronic modules 1000, 1100 and the associated slider 1010 'are placed in the handle 20, movable relative to the body 10. Alternatively, one can imagine fixed modules by relation to the body 10.
    The present invention is particularly applicable for the treatment of asthma attacks or COPD (Broncho Obstructive Pulmonary Disease) in use with formulations of the type salbutamol, aclidinium, formoterol, tiotropium, budesonide, fluticasone, indacaterol, glycopyrronium, salmeterol, umeclidinium bromide, vilanterol, olodaterol, striverdi, or any combination of these formulations.
    The present invention has been described with reference to several advantageous embodiments and variants, but it is understood that a person skilled in the art may make any modifications thereto, without departing from the scope of the present invention as defined by the appended claims.
    权利要求:
    Claims (14)
    [1" id="c-fr-0001]
    claims
    1. - Device for dispensing fluid product synchronized with inhalation, comprising a body (10; 10 ') provided with a mouthpiece (400), a product reservoir (100) containing a fluid and a propellant being axially slidably mounted in said body (10; 10 '), a metering valve (200) having a valve (210) being assembled on said reservoir (100) for selectively dispensing the fluid, characterized in that said device comprises: - a an actuating element (500, 500 ', 500 ", 550) displaceable and / or deformable between a non-actuating position, in which said metering valve (200) can not be actuated, and an actuating position, in which said metering valve (200) can be actuated, - an inhalation controlled triggering system comprising an inhalation sensitive member (60, 61, 65, 66), deformable and / or displaceable under the effect of the inhalation, said inhala sensitive organ (60, 61; 65, 66) as it deforms and / or moves, displacing and / or deforming said actuating element (500, 500 ', 500 "; 550) from its non-actuating position to its actuating position, - an electronic dose counter (1000), and - signal transmission means (1100) for remote communication including information relating to the actuations of the device.
    [2" id="c-fr-0002]
    2, - Device according to claim 1, wherein said actuating element is a locking element (500, 500 ', 500 ") which, in the non-actuating position, cooperates on the one hand with the body (10; ') and on the other hand with the reservoir (100) to prevent the axial displacement of said reservoir (100) in the body (10; 10').
    [3" id="c-fr-0003]
    3. - Device according to claim 2, comprising a trigger element (600, 600 ') movable and / or deformable between a locking position, in which it blocks said locking element (500, 500 ") in its locking position, and a release position, in which it does not block said locking element (500, 500 ").
    [4" id="c-fr-0004]
    4. - Device according to claim 3, wherein said triggering system controlled by inhalation comprises a deformable membrane (61) defining a deformable air chamber (60), said deformable membrane (61) being fixed to said trigger element ( 600, 600 '), said deformable membrane (61) being deformed upon inhalation so that it moves said trigger member (600, 600') from its blocking position to its release position.
    [5" id="c-fr-0005]
    5. - Device according to any one of the preceding claims, wherein an actuating member (800) is assembled on the reservoir (100) on the axially opposite side to said metering valve (200), said actuating member (800). ) having a hollow sleeve (801) axially displaceable relative to said reservoir (100) between a rest position and a loaded position, a spring (850) being disposed between the bottom of the reservoir (100) and the closed upper edge of said hollow sleeve (801), so that when the user manually presses said actuating member (800) to move it to its loaded position, said spring (850) is compressed to transmit an axial force (F) to said reservoir (100). ).
    [6" id="c-fr-0006]
    6. - Device according to claim 5, wherein a lateral actuating handle (20) is pivotally mounted on the body (10; 10 ') between a rest position and a position of use in which it moves axially said body actuator (800) in its loaded position.
    [7" id="c-fr-0007]
    7. - Device according to any one of the preceding claims, wherein said body (10; 10 ') comprises an opening (13) connecting the mouthpiece (400) with the inside of the body (10), said opening ( 13) being closed at the beginning of inhalation by a valve (14), so that the inhalation flow is initially mainly transmitted to the trigger system by inhalation.
    [8" id="c-fr-0008]
    8. - Device according to claim 2, wherein said locking element (500 ') comprises an axial extension (505), a lower end (506) is fixed radially and axially relative to said body (10) and an upper end cooperates with said reservoir (100) in the non-operating position.
    [9" id="c-fr-0009]
    9. - Device according to claim 8, wherein said triggering system controlled by inhalation comprises a piston (65) sliding in a chamber (66) between a rest position and an inhalation position.
    [10" id="c-fr-0010]
    10. - Device according to claim 9, wherein said locking element (500 ') is assembled on a rod (540) integral with the piston (65), so that during inhalation, said rod (540) moves radially deforming and / or displacing said axial extension (505) towards its actuating position.
    [11" id="c-fr-0011]
    11. - Device according to claim 1, wherein said actuating element is a locking element (550) which, in the non-actuating position, allows axial displacement of said valve (210) of the metering valve (200) together. with said reservoir (100) in the body (10), preventing actuation of said metering valve (200) when said reservoir (100) is axially displaced in the body (10) without inhalation.
    [12" id="c-fr-0012]
    12. - Device according to claim 11, wherein, during inhalation, said locking element (550) moves and / or deforms to block the axial displacement of the valve (210) relative to the body (10). .
    [13" id="c-fr-0013]
    13. - Device according to claim 12, wherein said triggering system controlled by inhalation comprises a piston (65) sliding in a chamber (66) between a rest position and an inhalation position.
    [14" id="c-fr-0014]
    14. - Device according to claim 13, wherein said locking member (550) is integral with a rod (540) integral with the piston (65), so that during inhalation, said rod (540) moves radially moving said locking member (550) to its actuating position in which it prevents axial displacement of said metering valve (210) valve (200) when said reservoir (100) is axially displaced in the body (10) .
    类似技术:
    公开号 | 公开日 | 专利标题
    EP3442630B1|2020-01-29|Device for inhalation-synchronised dispensing of a fluid product
    EP3442631B1|2020-04-29|Device for inhalation-synchronised dispensing of a fluid product
    EP3442632B1|2020-02-05|Device for the dispensing of a fluid product synchronised with inhalation
    EP3220985B1|2018-10-31|Device for dispensing a fluid product triggered by inhalation.
    EP1313524B1|2005-08-10|Improved fluid product dispenser
    EP2827927A1|2015-01-28|Duckbill valve and inhalation device including such a valve
    EP3697482B1|2021-12-08|Device for inhalation-synchronized dispensing of a fluid product
    FR3072295B1|2019-10-11|DEVICE FOR DISPENSING FLUID PRODUCT SYNCHRONIZED WITH INHALATION.
    EP3717048B1|2021-08-18|Device for inhalation-synchronised dispensing of a fluid product
    WO2005113384A1|2005-12-01|Fluid product dispenser
    FR3092251A1|2020-08-07|Fluid dispenser device synchronized with inhalation and method of assembling said device
    FR3092252A1|2020-08-07|Fluid dispenser device synchronized with inhalation
    FR3092250A1|2020-08-07|Fluid dispenser device synchronized with inhalation
    FR2753791A1|1998-03-27|POWDER DISPENSER WITH TILTING DOSING CHAMBER
    FR2787031A1|2000-06-16|IMPROVED INHALATION DEVICE
    WO2020109737A1|2020-06-04|Device for inhalation-synchronised dispensing of a fluid product
    同族专利:
    公开号 | 公开日
    JP2019513478A|2019-05-30|
    EP3442632B1|2020-02-05|
    WO2017178767A1|2017-10-19|
    JP6936249B2|2021-09-15|
    CN109069766B|2021-03-23|
    US20210187210A1|2021-06-24|
    FR3050116B1|2020-05-15|
    EP3442632A1|2019-02-20|
    CN109069766A|2018-12-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    EP0441643A1|1990-02-09|1991-08-14|Yvan Pesenti|Inhalation device|
    US5060643A|1990-08-07|1991-10-29|Tenax Corporation|Breath-activated inhalation device|
    WO1992005824A1|1990-10-04|1992-04-16|Valois|Powder inhaler comprising powder microdoses contained in a flexible band, and manufacturing method|
    FR2775668A1|1998-03-04|1999-09-10|Tebro|DEVICE FOR DISPENSING FLUID PRODUCT TRIGGERED BY INHALATION|
    DE202004021188U1|2003-07-14|2007-03-15|Neo-Inhalation Ltd., Odiham|Inhalator for releasing appropriate quantity of medicine, has fluid channel and foldable holding device, which is locked by locking device operating as function of flow of inhaled breath in fluid channel|
    NZ504021A|1997-10-17|2003-04-29|Systemic Pulmonary Delivery Lt|Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication|
    GB0222295D0|2002-09-25|2002-10-30|3M Innovative Properties Co|Breath actuated medicament dispensing devices|
    GB0304000D0|2003-02-21|2003-03-26|Clinical Designs Ltd|Dispenser|
    GB0518400D0|2005-09-09|2005-10-19|Clinical Designs Ltd|Dispenser|
    WO2008023018A1|2006-08-22|2008-02-28|Glaxo Group Limited|Actuator for an inhaler|
    US8225790B2|2007-01-02|2012-07-24|Astrazeneca Ab|Inhaler 624|
    CN102470227B|2009-08-07|2014-06-04|亲切消费者有限公司|An inhaler|
    ES2604482T3|2010-06-18|2017-03-07|Boehringer Ingelheim International Gmbh|Inhaler|
    FR2973012B1|2011-03-21|2013-04-26|Valois Sas|DEVICE FOR DISPENSING FLUID PRODUCT WITH SIDE ACTUATION.|
    GB201118845D0|2011-11-01|2011-12-14|Euro Celtique Sa|Dispenser|
    GB201322677D0|2013-12-20|2014-02-05|3M Innovative Properties Co|Actuator for an inhaler|
    GB201408229D0|2014-05-09|2014-06-25|Norton Waterford Ltd|Aerosol device|
    FR3050114B1|2016-04-15|2021-12-03|Aptar France Sas|FLUID PRODUCT DISTRIBUTION DEVICE SYNCHRONIZED WITH INHALATION.|FR3050114B1|2016-04-15|2021-12-03|Aptar France Sas|FLUID PRODUCT DISTRIBUTION DEVICE SYNCHRONIZED WITH INHALATION.|
    FR3074051B1|2017-11-29|2019-11-22|Aptar France Sas|DEVICE FOR DISPENSING FLUID PRODUCT SYNCHRONIZED WITH INHALATION|
    FR3077496A1|2018-02-06|2019-08-09|Nemera La Verpilliere|DEVICE FOR ASSISTING THE USE OF AN AXIAL ACTIVATION DISTRIBUTION DEVICE|
    法律状态:
    2017-04-26| PLFP| Fee payment|Year of fee payment: 2 |
    2017-10-20| PLSC| Search report ready|Effective date: 20171020 |
    2018-04-24| PLFP| Fee payment|Year of fee payment: 3 |
    2019-04-26| PLFP| Fee payment|Year of fee payment: 4 |
    2020-04-27| PLFP| Fee payment|Year of fee payment: 5 |
    2021-04-28| PLFP| Fee payment|Year of fee payment: 6 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1653375A|FR3050116B1|2016-04-15|2016-04-15|DEVICE FOR DISPENSING SYNCHRONIZED FLUID PRODUCT WITH INHALATION|
    FR1653375|2016-04-15|FR1653375A| FR3050116B1|2016-04-15|2016-04-15|DEVICE FOR DISPENSING SYNCHRONIZED FLUID PRODUCT WITH INHALATION|
    US16/093,498| US20210187210A1|2016-04-15|2017-04-13|Device for the dispensing of a fluid product synchronised with inhalation|
    PCT/FR2017/050894| WO2017178767A1|2016-04-15|2017-04-13|Device for the dispensing of a fluid product synchronised with inhalation|
    JP2018553994A| JP6936249B2|2016-04-15|2017-04-13|Intake synchronous fluid discharge device|
    CN201780023120.5A| CN109069766B|2016-04-15|2017-04-13|Device for dispensing a fluid product in synchronism with inhalation|
    EP17723447.3A| EP3442632B1|2016-04-15|2017-04-13|Device for the dispensing of a fluid product synchronised with inhalation|
    [返回顶部]