• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a composition comprising, in combination: - at least one prebiotic; at least one probiotic fraction; and - lactic acid. It also relates to the use of a composition according to the invention as a product intended for application to superficial body growths, in particular the skin.
    公开号:FR3040624A1
    申请号:FR1558386
    申请日:2015-09-09
    公开日:2017-03-10
    发明作者:Marie Drago
    申请人:Marie Drago；
    IPC主号:
    专利说明:

    COMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND ACID
    LACTIC
    The present invention relates to compositions for a cutaneous application comprising, in combination: - prebiotics; - probiotic fractions; and - lactic acid.
    This combination allows a triple action on the skin microbiome: - supply of nutrients to good skin bacteria with prebiotics; - stimulation of the immune system of the skin with probiotic fractions; and - skin care while creating an optimal environment for good bacteria thanks to lactic acid.
    [0003] "Prebiotic" is understood to mean a non-digestible food ingredient beneficially affecting the host by stimulating the growth and / or activity of one or a limited number of colon bacteria. This 1995 definition was refined in 2004 with the following three characteristics: - resistance to gastric acidity, hydrolysis by mammalian enzymes and gastrointestinal absorption; - fermentation by intestinal microflora; - selectively stimulates the growth and / or activity of intestinal bacteria associated with health and well-being.
    Prebiotics are all sugars, they are considered as non-digestible fibers and can be classified according to their degree of polymerization: monosaccharides; There is for example Tagatose, which is naturally present in small amounts in nature, and which can be produced from lactose by isomerization of galactose. Mostly known for its sweetening and antidiabetic properties, it is also degraded by certain enterococcus and Lactobacillus bacteria. - disaccharides; There is for example lactulose. Composed of a fructose and a galactose, it is a natural product derived from the treatment of milk by high temperature. Studies show prebiotic activity on Bifidus bacteria, but it is marketed primarily for its osmotic laxative qualities. oligosaccharides; The most common is Inulin, an oligofructose polymer (abbreviated FOS for Fructo-oligosaccharides) naturally present in nature. Depending on the degree of polymerization one can also speak of oligofructose.
    There are also other oligosaccharides, such as Transgalactooligosaccharides (TOS): a mixture of oligosaccharides derived from lactose by enzymatic transglycosylation. Their precise content depends on the original saccharides and the enzymes used. Generally, they are tri-, tetra- or pentasaccharides: polydextrose, Galactooligosaccharides (GOS) which are naturally present for example in colostrum and breast milk.
    [0009] "Probiotic" is understood to mean living microorganisms which, when they are administered in adequate quantities, confer a health benefit on their host. It is important to note that dead organisms, even though they may have activity, should not be called probiotics.
    Probiotics can be bacteria or yeasts.
    Bacteria: genera Lactobacillus and Bifidobacterium. The strains identified as probiotic apply mainly to the intestinal sphere, these include, respectively, Lactobacillus acidophilus, L. casei, L. gasseri, L. paracasei, L. Rhamnosus and Bifidobacteria animal, B. breve, B longum. - Yeasts: Saccharomyces cerevisiae var. boulardii found naturally in the lychee.
    By "synbiotic" is meant a mixture of prebiotics and probiotics. Since the term evokes synergy, it should only be used when the action of this precise prebiotic stimulates the growth of the probiotics of the mixture.
    Lactic acid can be considered a "postbiotic" term used to define bacterial products or metabolites of probiotic organisms that have a biological activity on the host. Lactic acid belongs to the group of alpha-hydroxy acids such as glycolic acid, citric acid and malic acid. Naturally produced by the muscles of the human body, it is also synthesized by certain bacteria (lactic acid bacteria).
    Lactic acid being a chiral molecule, it is found in three forms: D, L, or DL. Humans only synthesize the L-form, while bacteria can synthesize both forms. Since lactic acid is used primarily as a food ingredient, there is a tendency to find more available L-form. In cosmetic use, there is less irritation with the L-shape.
    These assets in combination, namely the at least one prebiotic, the at least one probiotic fraction and lactic acid are hydrophilic active ingredients and their formulation in compositions for application to the skin, which are often emulsions, present a number of difficulties, particularly in terms of rheology or viscosity as well as problems of conservation and phase shift.
    Surprisingly these problems could be solved by setting the pH in an interval between 4 and 6, this interval being a pH range little used in cosmetic formulation.
    The present invention relates to a composition, comprising, in combination: [00018] at least one prebiotic; at least one probiotic fraction and; r lactic acid.
    The invention also relates to the use of a composition according to any one of the preceding claims as a product intended for application to superficial body growths, in particular the skin.
    In one embodiment, the lactic acid is L-shaped.
    In one embodiment, the prebiotic is selected from the group consisting of inulin and alphaglucan oligosaccharide.
    These compounds are marketed in various forms and under various denominations and trade names, some examples of which are given as examples in Table 1.
    Table 1 [00023] In one embodiment, the composition is characterized in that the probiotic fraction is selected from the group consisting of probiotic lysates.
    In one embodiment, the probiotic lysate is a lysate of the genus Bacillus.
    [00025] Probiotics or probiotic fractions are marketed in various forms and under various names and trade names, some examples of which are given as examples in Table 2.
    Table 2 [00026] In one embodiment, the sum of the prebiotic and probiotic content is between 0.5 and 6% by weight relative to the total weight of said composition.
    In one embodiment, the sum of the contents of prebiotic and probiotic fraction is between 1 and 5% by weight relative to the total mass of said composition.
    In one embodiment, the sum of the contents of prebiotic and probiotic fraction is between 2 and 4% by weight relative to the total weight of said composition.
    In one embodiment, the prebiotic content is between 0.5 and 2% by weight relative to the total weight of said composition.
    In one embodiment, the prebiotic content is between 0.5 and 1.5% by weight relative to the total weight of said composition.
    In one embodiment, the prebiotic content is between 0.75 and 1.25% by weight relative to the total weight of said composition.
    In one embodiment, the lactic acid content is between 0.5 and 5 by weight relative to the total weight of said composition.
    In one embodiment, the lactic acid content is between 1 and 4% by weight relative to the total weight of said composition.
    In one embodiment, the lactic acid content is between 2 and 3% by weight relative to the total weight of said composition.
    In one embodiment, the content of probiotic fraction is between 0.5 and 4% by weight relative to the total weight of said composition.
    In one embodiment, the content of probiotic fraction is between 1 and 3% by weight relative to the total weight of said composition.
    In one embodiment, the content of probiotic fraction is between 1.5 and 2% by weight relative to the total weight of said composition.
    In one embodiment, the at least one prebiotic and the at least one probiotic fraction form a synbiotic.
    In one embodiment, the pH of the composition is between 4 and 6.
    In one embodiment, the pH of the composition is between 5 and 5.5.
    The compositions according to the invention are intended for applications on integuments, especially on the skin for cosmetic and pharmaceutical use.
    The compositions of the invention may further comprise preservatives taking into account the preservative effects of lactic acid.
    The actions of the compositions according to the invention on the skin are selected from the group consisting of: - protective action and rebalancing soft for all skin types; - action promoting the growth of beneficial microbial flora to the detriment of unwanted and pathogenic flora; - action of stimulation of the natural mechanisms of defense of the skin; - action of selective stimulation of the good cutaneous flora; action of inhibiting the growth of undesirable flora; - action of stimulation of the beta-defensins of the skin; - action to improve the radiance and comfort of the skin; - restructuring, nourishing, smoothing action; - action to reduce the feeling of discomfort; - action of increase of cellular renewal to reveal a skin of younger aspect; - exfoliating action for all skin types; - hydration action; - action to reduce wrinkles and fine lines.
    The compositions according to the invention may further comprise the conventional ingredients used in pharmaceutical and / or cosmetic formulation.
    The composition according to the invention may further comprise conventional adjuvants chosen in particular from fatty substances, organic solvents, ionic or nonionic thickeners, softeners, antioxidants, opacifiers, stabilizers, emollients, silicones, α-hydroxy acids, anti-foam agents, moisturizers, vitamins, perfumes, preservatives, surfactants, fillers, sequestering agents, polymers, propellants, basifying or acidifying agents, dyes, or any other ingredient usually used for the manufacture of compositions in the form of emulsions.
    The fatty substances may consist of an oil or a wax or mixtures thereof, and they also include fatty acids, fatty alcohols and fatty acid esters. The oils may be chosen from animal, vegetable, mineral or synthetic oils and in particular from liquid petroleum jelly, liquid paraffin, silicone oils, which may or may not be volatile, isoparaffins and poly-α-olefins. fluorinated and perfluorinated oils. Similarly, the waxes can be chosen from animal, fossil, vegetable, mineral or synthetic waxes known per se.
    Among the organic solvents, there may be mentioned lower alcohols and polyols.
    The thickeners may be chosen in particular from crosslinked polyacrylic acids, guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, methylhydroxyethylcellulose and hydroxypropylmethylcellulose.
    The composition according to the invention may be prepared according to the techniques well known to those skilled in the art, in particular those intended for the preparation of oil-in-water (O / W) type emulsions or water -in-oil (W / O).
    The composition according to the invention may be in particular in emulsion form, simple or complex (O / W, W / O, O / W / H or W / O / W) such as a cream, a milk, a gel or a cream gel, powder, solid stick and possibly be packaged in aerosol and be in the form of foam or spray.
    The composition according to the invention may further comprise one or more UV-A and / or UV-B active UV filters, hydrophilic or lipophilic.
    These filters may be chosen from cinnamic derivatives, salicylic derivatives, camphor derivatives, triazine derivatives, benzophenone derivatives, dibenzoylmethane derivatives, β, β-diphenylacrylate derivatives, p-Aminobenzoic Acid Derivatives, Polymeric Filters and Silicone Filters The composition according to the invention may furthermore comprise pigments or else nanopigments of coated or uncoated metal oxides, for example nanopigments of titanium oxide (amorphous or crystallized in rutile form and / or anatase) of iron, zinc, zirconium or cerium which are all known photoprotective agents acting by physical blocking (reflection and / or diffusion) of UV radiation. Conventional coating agents are, moreover, alumina and / or aluminum stearate.
    The following compositions according to the invention have been prepared, by way of examples:
    Example 1
    Table 3: Formulation 1 [00054]
    Example 2
    Table 4: Formulation 2 Example 3
    Table 5: Formulation 3
    Example 4
    Table 6: Formulation 4
    权利要求:
    Claims (12)
    [1" id="c-fr-0001]
    1. Composition comprising, in combination: - at least one prebiotic; at least one probiotic fraction; and - lactic acid.
    [2" id="c-fr-0002]
    2. Composition according to claim 1, characterized in that the pH of the composition is between 4 and 6.
    [3" id="c-fr-0003]
    3. Composition according to any one of the preceding claims, characterized in that the prebiotic is selected from the group consisting of inulin and aiphaglucan oligosaccharide.
    [4" id="c-fr-0004]
    4. Composition according to any one of the preceding claims, characterized in that the probiotic fraction is selected from the group consisting of probiotic lysates.
    [5" id="c-fr-0005]
    5. Composition according to claim 3, characterized in that the probiotic lysate is a lysate of the genus Bacillus.
    [6" id="c-fr-0006]
    6. Composition according to any one of the preceding claims, characterized in that lactic acid is form L.
    [7" id="c-fr-0007]
    7. Composition according to any one of the preceding claims, characterized in that the prebiotic content is between 0.5 and 2% by weight relative to the taotal mass of said composition.
    [8" id="c-fr-0008]
    8. Composition according to any one of the preceding claims, characterized in that the prebiotic content and probiotic fraction is between 0.5 and 6% by weight relative to the taotal mass of said composition.
    [9" id="c-fr-0009]
    9. Composition according to any one of the preceding claims, characterized in that the lactic acid content is between 0.5 and 5% by weight relative to the taotal mass of said composition.
    [10" id="c-fr-0010]
    10. Composition according to any one of the preceding claims, characterized in that the content of probiotic fraction is between 0.5 and 4% by weight relative to the taotal mass of said composition.
    [11" id="c-fr-0011]
    11. Composition according to any one of the preceding claims, characterized in that the at least one prebiotic and the at least one probiotic fraction form a synbiotic.
    [12" id="c-fr-0012]
    12. Use of a composition according to any one of the preceding claims as a product intended for application to superficial body growths, in particular the skin.
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    同族专利:
    公开号 | 公开日
    FR3040624B1|2019-07-26|
    引用文献:
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    法律状态:
    2016-09-23| PLFP| Fee payment|Year of fee payment: 2 |
    2017-03-10| PLSC| Search report ready|Effective date: 20170310 |
    2017-07-19| PLFP| Fee payment|Year of fee payment: 3 |
    2018-01-26| TP| Transmission of property|Owner name: GALLINEE LTD, GB Effective date: 20171218 |
    2018-08-16| PLFP| Fee payment|Year of fee payment: 4 |
    2019-08-31| PLFP| Fee payment|Year of fee payment: 5 |
    2020-09-30| PLFP| Fee payment|Year of fee payment: 6 |
    2021-09-25| PLFP| Fee payment|Year of fee payment: 7 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1558386A|FR3040624B1|2015-09-09|2015-09-09|COMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND LACTIC ACID|
    FR1558386|2015-09-09|FR1558386A| FR3040624B1|2015-09-09|2015-09-09|COMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND LACTIC ACID|
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