• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a capacitive electrode for measuring a physiological parameter of a subject, comprising: a body (32) made of electrically insulating material, the body (32) comprising a base (31) and a plurality of protuberances (34); ) projecting from the base (31), and - a plurality of capacitive elements (37) of electrically conductive material, embedded within the body (32), each capacitive element (37) being disposed within the body (32), at one end of the respective protuberances (34), so that when the ends of the protuberances (34) are in contact with the subject's skin, the capacitive elements are at a distance predefined skin.
    公开号:FR3039979A1
    申请号:FR1557676
    申请日:2015-08-11
    公开日:2017-02-17
    发明作者:Sylvain Zorman；Pierre Prot；Pierre-Yves Frouin
    申请人:Bioserenity SAS；
    IPC主号:
    专利说明:

    FIELD OF THE INVENTION
    The present invention relates to a device for measuring a physiological parameter of a subject, in the form of a capacitive electrode.
    STATE OF THE ART Electrophysiology is the study of these physiological signals of an electrical nature. The most common measurements are measurement of muscle activity by electromyogram, recording of cardiac muscle activity by electrocardiogram or brain activity by electroencephalogram.
    These signals can be measured directly at the level of the skin measurement area non-invasively.
    In order to continuously monitor the physiological state of a user, it is known to place conductive electrodes in contact with the skin measurement zone. Thanks to the electrical contact of the electrode at the cutaneous measurement zone, the electrical potential variations resulting from the electrophysiology activity vary the electrical potential of the electrode. These variations are then directly recorded by an electronic circuit.
    However, the operation of this type of sensor requires a good electrical contact with the skin measurement zone which is generally obtained by the use of a gel or other aqueous conductive substance. The use of a conductive substance greatly degrades the ergonomics of the system for the subject, the stability of its characteristics over time and the time of placement of the electrodes in particular outside of research or care centers.
    Cognionics, g.tec, emotiv and neuroelectrics have developed dry conductor type electrodes that do not require the addition of an electrical contact gel between the skin measurement zone and the electrode. These devices are described in US4967038 A, US8326396 B2, U S8644904 B2, US8548554 B2.
    However, said dry conductor type electrodes require electrical contact with the skin measurement zone and possible skin irritation. On the other hand, the weakness of the electrical contact between the electrodes and the cutaneous measurement zone results in a strong impedance and in a degradation of the quality of the electrophysiological signals collected. For these systems, sweating is also a source of signal quality degradation.
    In order to overcome these limitations, so-called capacitive electrodes that do not require electrical contact have been proposed.
    GB 2353594A discloses said capacitive electrodes for electrophysiological measurements. But the absence of a suitable geometry does not ensure a repeatable and stable distance with the skin measurement zone, especially in areas with high capillarity such as the scalp. The effective capacitance of the electrode is therefore subject to fluctuations which degrade the recorded signal.
    Document US 2014/0171775 discloses an intra-auricular capacitive electrode system. This positioning of the electrode is not part of the standards of electrophysiology, such a measurement is generally not usable in a medical or research environment.
    SUMMARY OF THE INVENTION
    An object of the invention is to propose a method for measuring an electrophysiological parameter by means of a capacitive measurement device integrated into a support allowing improved accuracy and ergonomics.
    This object is achieved by means of capacitive electrodes for measuring a physiological parameter of a subject comprising inter alia an insulating body, conductive capacitive elements.
    The body is made of electrically insulating material. It comprises a base and a plurality of protuberances projecting from the base. These protuberances make it possible to pass through the capillary elements so that the end of the protuberances is in direct mechanical contact with the measurement zone.
    Each of the capacitive elements is made of electrically conductive material embedded inside the body. Each capacitive element is disposed inside the body, at one end of the respective protuberances, so that when the ends of the protuberances are in contact with the skin of the subject, the capacitive elements are at a predetermined distance and constant from the skin.
    These two characteristics make it possible to place the measuring element, the capacitive element, at a fixed distance from the measurement zone in order to obtain a fixed capacitance reproducible and not affected by sweating.
    The capacitive electrodes above may furthermore have at least one of the following characteristics: capacitive electrodes comprise an electronic card extending inside the base of the body, and an electrically conductive wire connecting each capacitive element to the electronic card.The electronic card can be configured to generate a measurement signal of the physiological parameter according to the electrical potentials of the capacitive elements. Capacitive electrodes may also include a shielding layer disposed within the body, and extending over a portion of the base. The shielding layer reduces the sensitivity to electromagnetic disturbances not coming from the measurement zone. - The shielding layer may optionally be disposed between the electronic card and the capacitive elements. The capacitive electrodes may furthermore have a connector extending through the body for connecting the electronic card to an external device for processing electrical signals representative of an electrical potential measured by the capacitive elements. The body of the electrode may be formed by molding the electrically insulating material directly on the capacitive elements. The invention also relates to a device for measuring a physiological parameter of a subject comprising: a support capable of coating a part of the body of the subject; at least one capacitive electrode according to the preceding description, the capacitive electrode; being fixed on the support so that when the subject is coated with the support, the support holds the ends of the protuberances in contact with the skin of the subject.
    These supports also make it possible to position the capacitive electrodes simply and in a reproducible manner. The support allows the application of a mechanical stress between the sensor and the measurement zone. This mechanical stress makes it possible to minimize the disturbances associated with the movement of the sensor and ensures the mechanical contact of the sensor with the measurement zone.
    In one embodiment of the invention, the carrier may coat the subject's torso to allow recording of an electrocardiogram.
    In another embodiment of the invention, the support is adapted to coat the head of the subject to allow the recording of an electroencephalogram.
    In another embodiment of the invention, the support is adapted to coat the torso of the subject to allow the recording of an electromyogram.
    In one embodiment of the invention, the device comprises a reference capacitive electrode and one or more capacitive electrodes. It is indeed common in electrophysiology to perform so-called differential measurements by the use of a so-called reference electrode. The invention further relates to a method of measuring a physiological parameter of a subject, using a measuring device according to the foregoing description, comprising a step of: - obtaining a reference signal to the subject using capacitive reference electrodes, - obtain a measurement signal with capacitive electrodes of measurement, and - obtain a signal representative of the physiological parameter by subtraction of the reference signal from the measurement signal.
    In one embodiment of the invention, the method may also comprise a step of: applying a correction filter to the signal representative of the physiological parameter, the correction filter increasing the relative amplitude of certain frequency components of the signal with respect to other frequency components.
    Indeed, as explained below, the capacitive electrodes act as a high-pass filter. This filter modifies the signal which can be considered as an inconvenience. The application of a suitable filter (described below) makes it possible to remedy this defect by correcting the modifications of the frequency spectrum posteriorly in order to obtain a signal more representative of the variations of the electric potential of the measurement zone.
    PRESENTATION OF THE DRAWINGS Other characteristics and advantages will become apparent from the description which follows, which is purely illustrative and nonlimiting and should be read in conjunction with the appended figures.
    FIG. 1 schematically represents an example of a device for measuring an electrophysiological parameter according to one embodiment of the invention.
    FIGS. 2A and 2B show, schematically, another example of a device for measuring an electrophysiological parameter according to one embodiment of the invention.
    FIG. 3 is a diagrammatic bottom view of a capacitive electrode sensor according to an embodiment of the invention.
    FIG. 4 is a diagrammatic cross-sectional view of the capacitive sensor of FIG.
    FIG. 5 schematically represents, in top view, the capacitive electrode sensor of FIG. 3.
    FIG. 6A shows, schematically, an example of an electronic circuit of a capacitive electrode sensor as well as elements external to the capacitive electrode sensor.
    FIG. 6B shows, schematically, another example of an electronic circuit of a capacitive electrode sensor comprising a shielding system as well as elements external to the capacitive electrode sensor.
    DETAILED DESCRIPTION
    In FIGS. 1, 2a and 2b the electrophysiological signal measuring device comprises a plurality of integrated capacitive electrode sensors 11 in a support 111 in order to follow at least one electrophysiological parameter of a subject, for example an electromyogram or an electroencephalogram or a electrocardiogram.
    The support 111 is in the form of a garment, such as a t-shirt or cap, suitable for coating the measuring zone.
    The support 111 of the capacitive electrode sensors 11 has mechanical properties and a pattern for applying a mechanical stress at the level of the capacitive electrode sensors 11 improving the mechanical contact between the tip 33 of the protuberances 34 and the cutaneous measurement zone of the scalp 40.
    In the embodiment illustrated in FIG. 1, the support of the capacitive electrode sensors is a t-shirt surrounding the bust.
    In the embodiment illustrated in FIG. 1, the positioning of the capacitive electrode sensors from 13 to 19 allows the recording of cardiac electrical activity and the capacitive electrode sensors 101 to 104 of the electrical activity of muscles at the level of the arms. and the abdomen.
    The position of the capacitive electrode sensors 11 is predefined so that the threading of the measuring device by the user causes the positioning of the capacitive electrode sensors 11 at predetermined and reproducible locations of the body allowing the measurement of the electrophysiological parameter (s). interest.
    In a particular embodiment, the device for measuring a physiological parameter is an electroencephalogram helmet 2.
    In a particular embodiment, the positions of the capacitive electrode sensors in the cup 2 follow a well known type 10-20 mounting, as in the embodiment described in FIG. 2B.
    In a particular embodiment, a chin strap 23 may be included in said electroencephalogram helmet 2 so as to increase the mechanical stresses on the capacitive electrode sensors at the level of the scalp in order to improve the mechanical contact between said tips 33 of the protuberances 34 and the skin measurement zone 40.
    Figures 3 and 4 show an embodiment of the capacitive electrode sensors 3.
    In one embodiment the capacitive electrode sensors 3 are formed of a body 32 of electrically insulating material. The body comprises a flat bottom 31 of 0.5cm to 3cm and a plurality of protuberances 34 projecting from the base 31.
    A plurality of capacitive element 301 of electrically conductive material, embedded inside the body 32, at the end of a protuberance 34, so that when the ends of the protuberances 34 are disposed in contact with the skin of the subject 40, the capacitive elements 37 of the electrodes extend at a predetermined distance from the skin forming a capacitor with the measurement zone 40.
    An electronic card 36 extends inside the base 31 of the body 32.
    Each capacitive element 37 is connected by a wire 38 to the electronic card 36.
    A connector 35, extending through the body 32 for connecting the electronic card 36 to an external device for recording or physiological signal processing.
    The protuberances 34 are distributed so that they are equidistant, periodic or pseudoperiodic depending on the embodiment chosen. The number, the distance between protuberances, the distribution on the base and the geometry of the protuberances are optimized so that the protuberances can cross the capillary thickness and to establish a direct mechanical contact with the cutaneous measurement zone of the subject.
    Thus, according to the subjects, the total absence or the very small number of capillary elements between the cutaneous measurement zone 40 and the tip 33 of the protuberances 34 resulting from the specificities of the embodiments presented here makes it possible to make it repeatable and stable at over time the distance between the skin measurement zone and the capacitive element 37. This has the effect of making the value of the capacitor formed between the cutaneous measuring zone and the capacitive element 37, repeatable and stable over time Significantly improve signal quality in the context of electro-capacitive sensors. The capacitive element 37, whose electrical potential is particularly sensitive to variations in the electric field at the resulting measurement zone 40 of 41 (see FIG. 4).
    Its electrical properties and its physical proximity to the skin measurement zone 40 couple the potential of the capacitive element 37 to the tip of the protuberance 34 to the electrical potential of the nearby skin measurement zone 40. The electrically insulating element surrounds all the elements of the capacitive electrode sensor with the exception of the connector 35. The insulating element 32 also gives the capacitive electrode sensor properties of mechanical strengths.
    In a particular embodiment, the protuberances 34 of which there are 3 to 50 have an elongated shape and a diameter of between 0.5 mm and 3 mm so that they can pass through the capillary zones and be in direct mechanical contact with the zone of contact. cutaneous measure 40.
    This mechanical contact with the cutaneous measurement zone of the ends 33 of said protuberances is constant during the measurement and ensures a constant and repeatable distance between the capacitive element 37 and the cutaneous measurement zone 40. This characteristic makes it possible to cancel the effects. cutaneous sweating on the measurement of electrophysiological potentials. The thickness of the insulating material 32 separating the element 37 from the cutaneous measurement zone 40 is between 50 μm and 500 μm depending on the desired characteristics.
    The value of the effective capacitance constituted by the elements 37 and 40 is a function of the geometry of the protuberances and the number of protuberances per capacitive electrode sensor. More specifically, the capacitance is a function of the diameter of said capacitive element 37, the thickness of the insulator 32 between the elements 37 and the skin measurement zone 40, the electrical permittivity of the insulating element 32 and the number of protuberances. This value of the capacitance can be estimated by using the relation C = e Na / d with C the effective capacitance of the capacitor formed by the measurement zone 40 and the element 37, e the permittivity of said material. The insulator 32, N the number of protuberances per physiological electrode, has the effective diameter of the capacitive element 37 and the thickness of the insulating element 32 between the element 37 and the skin measurement zone 40. estimation of capacitance can be performed using the well-known finite element method. In this approach, the skin measurement zone can be modeled by a plane.
    In the particular embodiment where the electrode contains a shielding member 39 disposed within the body and extending across the width of the base. The shield element 39 associated with the electronic elements 42, 43 and 44 of the capacitive electrode sensor makes it possible to reduce the noise generated by electromagnetic radiation produced by elements outside the measurement zone. The shielding element 39 is maintained at a particular electric potential according to a technique well known to those skilled in the art of using an operational amplifier 42 whose non-inverting input is electrically connected to the electrically conductive elements 37 of the protuberances 34. The inverting input is connected to both the shielding element 39 and the output of the operational amplifier 42. This electronic assembly called "follower" makes it possible to maintain the electrical potential of the shielding element 39 at the same potential. The shielding element 39 can then act effectively to protect the capacitive elements 301 from electromagnetic disturbances radiated by external devices. The output of the amplifier 42 having the same electrical potential as that present on the capacitive elements 301, it thus conveys a copy of the measured electrophysiological signal.
    The electro-capacitive sensor contains an electronic card 36 for amplifying and conditioning the electrophysiological signal copied at the output of the amplifier 42. This amplification and conditioning element is composed of the amplifier 43 and the resistors 44 and 444 as well as capacitor 45 whose electrical properties make it possible to determine the gain of the amplification. This gain, as well as the values of the resistors 44 and 444 and the capacitor 45, are determined according to well-known techniques, so that the level of the signal amplified at 43 is sufficient to be correctly digitized by the ADC 47. furthermore, the resistor 444 and the capacitor 45 just upstream of the ADC 47 form a low-pass filter whose characteristics can easily be determined.
    In FIG. 6b, the transfer function of the capacitive element 37 associated with the operational amplifier 43, in the embodiment containing a shield 39 and the amplifier 42, expressed in the polar coordinate frequency space is
    Hcapa = (l + RAo / ZCapa), with RA0 the effective input impedance of the elements 42 or 42 and 43 according to the embodiment and the impedance in polar coordinates Zcapa is defined by Zcapa = -i / ooC with i the imaginary unit ω the pulsation and C the capacitance capacitance of the capacitor, of which different estimation modes are described above.
    In a particular embodiment, the second electronic circuit 48 connected to the capacitive electrode sensor 3 comprises a digital filter whose transfer function Hfutre is the inverse of the transfer function Hcapa with
    Since the capacitance value of the capacitor, formed by the capacitive element 301 and the skin measurement zone 40, is stable over time and repeatable, the transfer function of the capacitive electrode sensor is also stable over time and repeatable. Thus, the digital filter, whose transfer function is predetermined, is always adapted to the transfer function of the electrode 3, which guarantees good signal quality, stable over time, and repeatable.
    权利要求:
    Claims (14)
    [1" id="c-fr-0001]
    A capacitive electrode for measuring a physiological parameter of a subject, comprising: a body (32) of electrically insulating material, the body (32) comprising a base (31) and a plurality of protuberances (34); projecting from the base (31), and - a plurality of capacitive elements (37) of electrically conductive material, embedded within the body (32), each capacitive element (37) being disposed at the inside the body (32), at one end of the respective protuberances (34), so that when the ends of the protuberances (34) are in contact with the skin of the subject, the capacitive elements are at a predetermined distance from the skin.
    [2" id="c-fr-0002]
    The capacitive electrode according to claim 1, comprising an electronic board (36) extending inside the base (31) of the body (32), and an electrically conductive wire (38) connecting each capacitive element (37). to the electronic card (36).
    [3" id="c-fr-0003]
    3. Capacitive electrode according to claim 2, wherein the electronic card (36) is configured to generate a measurement signal of the physiological parameter as a function of the electrical potentials of the capacitive elements (37).
    [4" id="c-fr-0004]
    4. Electrode according to one of claims 2 to 3, comprising a shielding layer (39) disposed within the body (32), and extending over a portion of the base (31).
    [5" id="c-fr-0005]
    An electrode according to claim 4, wherein the shielding layer (39) is disposed between the electronic board and the capacitive elements (37).
    [6" id="c-fr-0006]
    6. Electrode according to one of claims 2 to 5, comprising a connector (35) extending through the body (32) for connecting the electronic card to an external device for processing electrical signals representative of a measured electrical potential by the capacitive elements (37).
    [7" id="c-fr-0007]
    7. Electrode according to one of claims 1 to 6, wherein the body (32) is formed by molding the electrically insulating material directly on the capacitive elements (37).
    [8" id="c-fr-0008]
    8. A device for measuring a physiological parameter of a subject comprising: a support (111) capable of coating a part of the body of the subject, at least one capacitive electrode according to one of claims 1 to 7, capacitive electrode being attached to the carrier (111) so that when the subject is coated with the device, the carrier (111) holds the ends of the protuberances (34) in contact with the skin of the subject.
    [9" id="c-fr-0009]
    9. Device according to claim 8, wherein the support (1,111) is a clean clothing to coat the trunk of the subject to allow the recording of an electrocardiogram.
    [10" id="c-fr-0010]
    10. Device according to claim 8, wherein the support (2, 111) is a clean clothing to coat the head of the subject to allow the recording of an electroencephalogram.
    [11" id="c-fr-0011]
    11. Device according to claim 8, wherein the support (1,111) is a clean clothing to coat the trunk of the subject to allow the recording of an electromyogram.
    [12" id="c-fr-0012]
    12. Device according to one of claims 9 to 11, comprising a capacitive reference electrode and one or more capacitive electrode (s) measurement (s).
    [13" id="c-fr-0013]
    A method of measuring a physiological parameter of a subject, using a measuring device according to claim 12, comprising a step of: - obtaining a reference signal using the reference capacitive electrode, - obtain a measurement signal by means of the capacitive electrode (s) (s), and - obtain a signal representative of the physiological parameter by subtraction of the reference signal from the measurement signal.
    [14" id="c-fr-0014]
    The method according to claim 13, comprising a step of: applying a correction filter to the signal representative of the physiological parameter, the correction filter increasing the relative amplitude of certain frequency components of the signal relative to other components frequency.
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    同族专利:
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    TW201705904A|2017-02-16|
    US20180235499A1|2018-08-23|
    FR3039979B1|2017-09-01|
    AR105682A1|2017-11-01|
    CN108289609A|2018-07-17|
    JP6858748B2|2021-04-14|
    IL257405D0|2018-04-30|
    WO2017025553A1|2017-02-16|
    KR20180039130A|2018-04-17|
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    法律状态:
    2016-08-12| PLFP| Fee payment|Year of fee payment: 2 |
    2017-02-17| PLSC| Publication of the preliminary search report|Effective date: 20170217 |
    2017-08-08| PLFP| Fee payment|Year of fee payment: 3 |
    2018-08-13| PLFP| Fee payment|Year of fee payment: 4 |
    2019-08-12| PLFP| Fee payment|Year of fee payment: 5 |
    2020-08-10| PLFP| Fee payment|Year of fee payment: 6 |
    2021-08-19| PLFP| Fee payment|Year of fee payment: 7 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1557676A|FR3039979B1|2015-08-11|2015-08-11|METHOD FOR MEASURING AN ELECTROPHYSIOLOGICAL PARAMETER USING A CAPACITIVE ELECTRODE SENSOR WITH CONTROLLED CAPACITY|FR1557676A| FR3039979B1|2015-08-11|2015-08-11|METHOD FOR MEASURING AN ELECTROPHYSIOLOGICAL PARAMETER USING A CAPACITIVE ELECTRODE SENSOR WITH CONTROLLED CAPACITY|
    CN201680047410.9A| CN108289609A|2015-08-11|2016-08-10|Method for the capacitive electrode sensor measurement electric-physiology parameter by means of controlled capacitance|
    US15/751,661| US20180235499A1|2015-08-11|2016-08-10|Method for measuring an electrophysiological parameter by means of a capacitive electrode sensor of controlled capacitance|
    EP16750821.7A| EP3334330A1|2015-08-11|2016-08-10|Method for measuring an electrophysiological parameter by means of a capacitive electrode sensor of controlled capacitance|
    JP2018506837A| JP6858748B2|2015-08-11|2016-08-10|A method of measuring electrophysiological parameters using a capacitive electrode sensor with a controlled capacitance.|
    TW105125434A| TW201705904A|2015-08-11|2016-08-10|Method for measuring an electrophysiological parameter by means of a capacitive electrode sensor with controlled capacitance|
    PCT/EP2016/069019| WO2017025553A1|2015-08-11|2016-08-10|Method for measuring an electrophysiological parameter by means of a capacitive electrode sensor of controlled capacitance|
    KR1020187006743A| KR20180039130A|2015-08-11|2016-08-10|Method for measuring electrophysiological parameters by a capacitive electrode sensor of controlled capacitance|
    ARP160102471A| AR105682A1|2015-08-11|2016-08-11|METHOD FOR MEASURING AN ELECTROPHYSIOLOGICAL FACTOR THROUGH A CAPACITIVE ELECTRODE SENSOR WITH CONTROLLED CAPACITANCE|
    IL257405A| IL257405D0|2015-08-11|2018-02-07|Method for measuring an electrophysiological parameter by means of a capacitive electrode sensor of controlled capacitance|
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