• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Generator of nanoparticulate aerosols and continuous aerosol generation procedure associated to said generator. The object of the present invention relates to a nanoparticulate aerosol generator, comprising a reservoir (1) of compressed gas connected, through an operation valve (8 '), to a reservoir (2) of nanoparticulate material, wherein said reservoir (2) comprises an aerosol outlet orifice (3). Advantageously, said deposit (2) of nanoparticulate material is connected or embedded, at its outlet, to a pressurized aerosol distribution chamber (4), equipped with an orifice (9) for exiting said aerosol to the outside of the chamber (4). The invention provides the possibility of using nanoparticles of different nature with sizes less than 100 nanometers, continuously over time during long production periods, exceeding three hours. The invention also relates to a process for the generation of continuous nanoparticulate aerosols associated with said generator. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2679721A1
    申请号:ES201730055
    申请日:2017-01-18
    公开日:2018-08-30
    发明作者:Jesús Santamaría Ramiro；Francisco BALAS NIETO；María Pilar LOBERA GONZÁLEZ；Alberto CLEMENTE CORNAGO
    申请人:Universidad de Zaragoza；
    IPC主号:
    专利说明:

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    (8, 8 ’, 8’ ’, 8’ ’) Gas flow control / regulation valves
    (9, 9 ’) Access holes to the pressurized distribution chamber
    (10, 10 ’) Inlet gas pressure control points
    (eleven) Pressurized distribution chamber humidity sensors
    (12) Mass flow controller
    (13) Spray generated
    (14) Flow control point of the generated aerosol DETAILED DESCRIPTION OF THE INVENTION
    A detailed description of the invention, referring to a preferred embodiment thereof based on Figures 1-2 of this document, is set forth below.
    As shown in Figures 1a-1b, the present invention relates to a nanoparticulate aerosol generator comprising, essentially, a reservoir
    (1) of compressed gas connected to a reservoir (2) of nanoparticulate material (see
    10 detail in Figure 1b), wherein said reservoir (2) comprises an outlet port (3) connected to a pressurized aerosol distribution chamber (4). According to this configuration, the reservoir (1) of compressed gas is a tank, for example stainless steel, which can have a variable volume depending on the application chosen, and which receives a first source (5) of gas flow (said gas being, for
    15 example, air) under controlled pressure. In an example of use for laboratory applications, said volume may be between 30-50 cm3, with air stored at a pressure of 7-10 barg. Preferably, the connection between the first gas flow source (5) and the reservoir (1) is made through a desiccator
    (6) and / or a filter (7) (for example, a HEPA type filter, or “High Efficiency Particle
    20 Arresting ”), with the aim of removing moisture from the aerosol generating air, as well as the impurities present in it. It is also possible, in other embodiments of the generator, to have a valve (8) between the first source (5) of gas flow and the reservoir (1), as a means of regulating said flow.
    As mentioned, the reservoir (1) of compressed gas is connected to a reservoir (2) of nanoparticulate material. Said tank (2) comprises a container (as an example, in Figure 1b a cylindrical container is shown) equipped with an outlet hole (3) for the release of the nanoparticulate aerosol. Typically, for a laboratory cylindrical generator, said reservoir (2) is between 80-120 mm long, 5
    8
    20mm internal diameter and has an outlet hole (3) between 1.0-1.4 mm internal diameter. Preferably, the tank (2) is made of stainless steel.
    By opening another bypass valve (8 ') disposed between the reservoir (1) of compressed gas and the reservoir (2) of nanoparticulate material, the compressed gas is released instantly, driving said solid material through the orifice (3) output The increase in the speed that the gas experiences when passing through the orifice (3) gives rise to great shear forces that break the agglomerates formed in the nanoparticulate powder, releasing a cloud of nanoparticles of the desired scale.
    In order to provide the generator of the invention with the ability to deliver the aerosol continuously, the reservoir (2) of nanoparticulate material is connected, or embedded, in the pressurized distribution chamber (4), which allows the aerosol to be maintained , once generated, in a state of dispersion thanks to the internal pressure at which said chamber is maintained (4). In different embodiments of the invention, the distribution chamber (4) can be, for example, a controlled atmosphere chamber, or a dispersion tube. This second case is shown in the representation illustrated by Figures 1a-1b, wherein said dispersion tube consists of a chamber (4) formed by several sections (4 ') (preferably stainless steel), for example cylindrical sections, each of them with an inner diameter between 8-12 cm and a height of 1525 cm. Each section preferably contains one or more holes (9, 9 ’) for access to the interior of the chamber (4) once mounted and the generator is in operation. Also, the ends of the chamber (4) consist of corresponding terminal sections (4 ’) of closure. The tank (2) (see Figure 1b) of nanoparticulate material that will be used to generate the aerosols is inserted or connected by one of said terminal sections (4 ''), while by another of the terminal sections (4 '') a second source (5 ') of gas flow is connected which serves to maintain the internal pressure at different values, depending on the specific needs of the generation. The connection of said source (5 ') to the distribution chamber (4) is carried out, for example, by means of a valve (8' '), optionally including the presence of a desiccator (6') and / or a filter ( 7 ') (for example, a HEPA filter). In both the pressurized distribution chamber (4) and the compressed gas reservoir (1) it is possible to include one or more control points (10, 10 ’) of the working pressure.
    In the preferred embodiment illustrated in Figures 1a-1b, the total chamber volume
    (4) distribution is 8-10 liters once disposed with the deposit (2) of material
    9
    image7
    Complete depends, ultimately, on the granulometry of the starting material and its chemical nature, the system being very versatile in terms of these two parameters.
    In short, the pressurized distribution chamber (5) allows the control of the concentration and distribution of particle size in the aerosol stream. These two parameters are of great interest in all applications that involve the use of nanoparticle aerosols in different technological fields, from the synthesis of gas phase materials to the validation of personal protective equipment in industrial hygiene, as well as in echo studies. -toxicity, toxicological investigation of nanomaterials by inhalation, quality controls, dispersion studies, filter tests and personal protection equipment, calibration of nanoparticle measuring equipment, simulation of accidents involving nanomaterials or medical applications.
    The results of aerosol generation are shown in Figures 2a and 2b using 25 mg of TiO2 nanoparticles with a nominal diameter of 25 nm (Aeroxide P25, Evonik, Germany) for a period of about 150 min, using a generator according to the embodiment illustrated in Figures 1a-1b. In them it can be observed that the concentration of the particles in the aerosol stream (Figure 2a) remains stable around 5 · 105 # / cm3 during the entire generation time, without a fall in this value being observed for more than two hours. The blanks in the concentration curve are due to the fact that the equipment for measuring the amount of matter in the aerosol was used to determine the measurement of particle size distribution. These distributions, as can be seen in Figure 2b, show similar average size and amplitude values, both at the beginning and at the end of the test. It should also be noted that the average size of the generated particles is around 50 nm, corresponding to small aggregates of 25 nm primary particles. These results therefore confirm that the aerosols generated with this system are of constant concentration and size for long periods of time.
    Another aspect of the invention relates to a process of continuous generation of nanoparticulate aerosols, by using a generator according to any of the embodiments described herein. Said process preferably comprises the following steps:
    a) A gas flow is introduced into the generator, compressing it into the reservoir
    eleven
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    权利要求:
    Claims (1)
    [1]
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    类似技术:
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    同族专利:
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    ES2679721B1|2019-06-21|
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5884846A|1996-09-19|1999-03-23|Tan; Hsiaoming Sherman|Pneumatic concentric nebulizer with adjustable and capillaries|
    US7357910B2|2002-07-15|2008-04-15|Los Alamos National Security, Llc|Method for producing metal oxide nanoparticles|
    JP2007291503A|2006-03-28|2007-11-08|Brother Ind Ltd|Aerosol generating apparatus, method for generating aerosol and film forming apparatus|
    US20080230053A1|2006-09-15|2008-09-25|Board Of Regents, The University Of Texas System|Pulse drug nebulization systems, formulations therefore, and methods of use|
    US8881997B2|2010-10-19|2014-11-11|West Virginia University|Nanoparticle aerosol generator|
    CN103353411B|2013-06-27|2015-05-27|西北核技术研究所|Quasi monodisperse nanometer aerosol generation system|
    US9533319B1|2014-05-28|2017-01-03|The United States Of America As Represented By The Secretary Of The Army|Aerosol generator and method|ES2615512B1|2015-11-06|2018-03-15|Universidad De Zaragoza|DEVICE AND MICROFLUIDIC SYSTEM FOR THE STUDY OF CELL CULTURES|
    CN109266515B|2018-09-21|2021-07-06|中国科学院生态环境研究中心|Closed aerosol generating device|
    法律状态:
    2018-08-30| BA2A| Patent application published|Ref document number: 2679721 Country of ref document: ES Kind code of ref document: A1 Effective date: 20180830 |
    2019-06-21| FG2A| Definitive protection|Ref document number: 2679721 Country of ref document: ES Kind code of ref document: B1 Effective date: 20190621 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201730055A|ES2679721B1|2017-01-18|2017-01-18|GENERATOR OF NANOPARTICULATED AEROSOLS AND PROCEDURE FOR GENERATION OF CONTINUOUS AEROSOLS ASSOCIATED WITH SUCH GENERATOR|ES201730055A| ES2679721B1|2017-01-18|2017-01-18|GENERATOR OF NANOPARTICULATED AEROSOLS AND PROCEDURE FOR GENERATION OF CONTINUOUS AEROSOLS ASSOCIATED WITH SUCH GENERATOR|
    US16/478,794| US20190366365A1|2017-01-18|2018-01-15|Nanoparticulate-aerosol generator and method for continuously generating aerosols, associated with said generator|
    PCT/ES2018/070027| WO2018134457A1|2017-01-18|2018-01-15|Nanoparticulate-aerosol generator and method for continuously generating aerosols, associated with said generator|
    EP18741991.6A| EP3572154A4|2017-01-18|2018-01-15|Nanoparticulate-aerosol generator and method for continuously generating aerosols, associated with said generator|
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