• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Nanoparticles with protected interiors, and methods of using them. The present invention relates generally to particles, including nanoparticles, for example, for the administration of drugs or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner part and a coating. The inner part may contain insulin or other therapeutic molecules for administration to a living being. In some cases, the molecules may be electrostatically complexed with a peptide of opposite charge, such as an oligoarginine, or other species. The species are typically positively charged, for example, for therapeutic molecules negatively ionized at neutral pH. The therapeutic molecules can also be soluble in water. In some cases, the peptide may be conjugated with a hydrophobic moiety, such as cholesterol, lauric acid, or a fatty acid chain. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2664584A1
    申请号:ES201631221
    申请日:2016-09-19
    公开日:2018-04-20
    发明作者:Maria Josefa Alonso Fernandez；Zhigao Niu；Manuel Jesus Santander Ortega
    申请人:Universidade de Santiago de Compostela；
    IPC主号:
    专利说明:

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    权利要求:
    Claims (1)
    [1]
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    同族专利:
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    ES2664584B2|2018-12-13|
    US10471020B2|2019-11-12|
    WO2018050942A8|2018-05-11|
    US20180078510A1|2018-03-22|
    WO2018050942A1|2018-03-22|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2005032593A1|2003-10-01|2005-04-14|Japan Science And Technology Agency|Polyarginine-modified liposome capable of transferring into nucleus|
    US8709472B1|2007-11-13|2014-04-29|Abbott Cardiovascular Systems Inc.|Bioactive agent-loaded heart-targeting nanoparticles|
    US9566349B2|2010-10-14|2017-02-14|Rutgers, The State University Of New Jersey|Intestinal peptide targeting ligands|
    ES2385995B2|2011-01-10|2013-05-21|Universidade De Santiago De Compostela|NANOCAPPSULES WITH POLYMER COVER|
    EP2886128A1|2013-12-20|2015-06-24|Nanobiotix|Pharmaceutical composition comprising nanoparticles, preparation and uses thereof|
    CN104434806B|2014-11-06|2017-05-03|中国人民解放军第四军医大学|Lipid-mixed poly nanoparticle having high drug loading amount and active targeting effect|
    CN104497147B|2014-12-23|2018-07-03|四川大学|A kind of cancer target nanoscale medicine delivery system of the tandem type cell-penetrating peptide modification of amboceptor identification|
    ES2664584B2|2016-09-19|2018-12-13|Universidade De Santiago De Compostela|NANOPARTICLES WITH PROTECTED INTERIOR, AND METHODS OF USE OF THE SAME|ES2664584B2|2016-09-19|2018-12-13|Universidade De Santiago De Compostela|NANOPARTICLES WITH PROTECTED INTERIOR, AND METHODS OF USE OF THE SAME|
    CN109260174B|2018-09-04|2021-10-15|中山大学|High-throughput preparation method of therapeutic protein nanoparticles|
    WO2021011398A1|2019-07-12|2021-01-21|The Board Of Trustees Of The Leland Stanford Junior University|Functionalized nanoparticles and their use in treating bacterial infections|
    法律状态:
    2018-12-13| FG2A| Definitive protection|Ref document number: 2664584 Country of ref document: ES Kind code of ref document: B2 Effective date: 20181213 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201631221A|ES2664584B2|2016-09-19|2016-09-19|NANOPARTICLES WITH PROTECTED INTERIOR, AND METHODS OF USE OF THE SAME|ES201631221A| ES2664584B2|2016-09-19|2016-09-19|NANOPARTICLES WITH PROTECTED INTERIOR, AND METHODS OF USE OF THE SAME|
    US15/350,653| US10471020B2|2016-09-19|2016-11-14|Nanoparticles with protected interiors, and methods of use thereof|
    PCT/ES2017/070617| WO2018050942A1|2016-09-19|2017-09-18|Nanoparticles with protected cores, and methods for using same|
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