• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Storage device for sample holders, which comprises a cylindrical body (1) including a plurality of holes (2) to detachably support sample holders (5), said holes (2) extending through the cylindrical body (1) in a direction parallel with respect to the longitudinal axis (L) of said cylindrical body (1). The cylindrical body (1) is made of polymeric material and comprises at least one cavity (4a, 4b) for compensating for dimensional variations in the material caused by changes in temperature, said at least one cavity (4a, 4b) extending through said material. cylindrical body (1). (Machine-translation by Google Translate, not legally binding)
    公开号:ES2657507A1
    申请号:ES201731129
    申请日:2017-09-20
    公开日:2018-03-05
    发明作者:Iñaki DE DIEGO MARTÍNEZ；Roeland BOER；Francisco MARTÍNEZ LÓPEZ
    申请人:Consorci per a la Construccio Equipament i Explotacio del Laboratori de Llum Sincrotro；
    IPC主号:
    专利说明:

    DESCRIPTION
    Storage device for sample holders.
    Object of the invention.
    The present invention relates to a storage device for sample holders. 5
    Background of the invention.
    The use of storage devices for crystalline sample holders is known. These crystalline samples, sometimes frozen, should be kept frequently at very low temperatures, usually in liquid nitrogen, for study in analysis or experimental stations, for example, in light lines of 10 synchrotron. Said storage devices allow storing the collected samples, for example, in a laboratory, and transporting said samples to facilities in which their analysis will be carried out.
    Standards have been developed to facilitate the manipulation of the samples and to increase the speed with which the samples can be transferred to the experimental stations 15, facilitating their arrangement in the experimental station and simplifying the transfer processes of the samples of the samples. storage device to said station.
    One type of sample holder widely used in the art and with which the device of the present invention will be used consists of a sample holder of a circular base type (eg, a goniometer base or "cap") with a rod that extends from said base. This type of sample holder generally comprises a circular base with a maximum outside diameter of approximately 12 mm at its bottom. The circular base can have various configurations, for example, it can have a conical shape in its upper part, or it can have 25 additional profiles of different diameter in its outer contour. The support also comprises a rod, usually in the form of a tube, which extends from the top of said base and in parallel with respect to the longitudinal axis of the circular base. This rod supports the sample to be analyzed at its free end. The approximate length
    of said rod can be 18 mm.
    Examples of this type of sample holder include Crystal CapTM goniometer stands or bases, produced by Hampton Research, CryoCapTM, produced by Molecular Dimensions, or goniometer bases produced by MiTeGen, or any other supports that are compatible with this type of 5 format or analogues to it.
    The sample holders described may also comprise a removable vial, cap or cover that fits into the base and covers the rod, insulating the sample from the outside. This vial makes it possible to handle an individual sample in a safer way, limiting the impact of the non-refrigerated environment or contact with other 10 elements on it, since said vial protects the sample from the outside environment, for example, when the sample holder is Remove from storage device.
    These sample holders can be housed in a type of storage device designed to protect them, for example, in a low temperature environment, such as in liquid nitrogen, and to be transferred together with the supports to the experimental station, such as a synchrotron light line, for example, to a sample exchange device thereof.
    This storage device is of the type called Puck, Basket, or Revolver, which comprises a cylindrical body that has an outer diameter of about 67 mm and that includes a plurality of holes extending through the body and in parallel with respect to its longitudinal axis, the corresponding sample holders described above supporting the samples to be analyzed being housed in said holes. Each sample holder is embedded in each of the holes of the cylindrical body, with the base 25 arranged at the height of the entrance hole of the corresponding hole and with the sample arranged at the end of the protected rod inside said hole. orifice.
    Two main modalities of this type of storage device are the so-called Uni-Puck or Universal Puck, developed by Stanford University, which comprises a cylindrical body with 16 longitudinal holes for the supports of 30
    samples described above, and the so-called SPINE Puck, which comprises a cylindrical body with the same diameter but with 10 holes for said sample holders.
    Examples of the Uni-Puck or Universal Puck type device include the Universal V1-Puck model, produced by Molecular Dimensions, or the Original Puck 5 (ALS-Style Puck) model, produced by MiTeGen.
    An example of the SPINE Puck type device comprises the SPINE Puck model (SC3 Basket), produced by MiTeGen.
    The existence of other commercial names of this type of storage device is possible. 10
    The described storage device and its holes are configured so that, once placed in the experimental station, for example in the exchange device thereof, the sample holders can be recognized and transferred for analysis, for example, by robotic means
    These storage devices are made of a metallic material, specifically, in aluminum. The process of mechanization of the cylindrical body is very laborious and complex and, consequently, the price of each storage device is considerable. Therefore, the cost of acquiring these storage devices can be a great inconvenience or even prohibitive for laboratories that need to keep numerous samples for analysis in an experimental station. The purchase of only one or a few storage devices of this type can also lead to an unacceptable disbursement for many laboratories that have limited budgets.
    Therefore, there is a need for a sample storage device of the type described above that can be produced economically and that avoids having to disburse considerable amounts of money for its acquisition. The existence of such an economic storage device will allow laboratories or institutions that use them to save considerable amounts of money in the storage of samples. Likewise, said storage device will allow users with fewer resources to use several of these 30
    devices, something that to date has not been possible due to the high cost of state-of-the-art devices.
    Description of the invention
    The objective of the present invention is to solve the drawbacks of the devices known in the art, by providing a storage device for sample holders of circular base type with a rod extending from said base, said device comprising a cylindrical body which includes a plurality of holes for removably housing said sample holders, said holes extending through the cylindrical body in a parallel direction with respect to the longitudinal axis of said cylindrical body, 10 characterized by the fact that the cylindrical body is of polymeric material and comprises at least one compensation cavity of dimensional variations in the material caused by temperature changes, said at least one cavity extending through said cylindrical body.
    Thanks to these characteristics, the storage device of the invention 15 constitutes a much cheaper alternative than the metal storage devices currently used, since being made of a polymeric material can be manufactured using much cheaper manufacturing methods, Especially 3D printing. Polymeric materials are more prone to dimensional variations and the consequent deterioration caused by temperature changes compared to metallic materials. It has been proven experimentally that an adequate arrangement of cavities through various parts of the cylindrical body makes it possible to compensate for the dimensional variations of the plastic material caused by the large changes in temperature to which the device of the invention can be subjected (for example, temperature 25 ambient at temperatures of the order of 100 degrees Kelvin (-173 ° C)), avoiding the appearance of cracks and fractures in the polymeric material, as well as an excess of dimensional changes, and thus solving a problem not present in the parts Metals of the prior art.
     30
    Preferably, the at least one cavity extends through the cylindrical body in a parallel direction with respect to the longitudinal axis of said cylindrical body.
    Also preferably, the at least one cavity is arranged in an intermediate space between several holes.
    Advantageously, the at least one cavity extends in a transverse direction 5 with respect to a direction parallel to the longitudinal axis of said cylindrical body.
    Also advantageously, the at least one cavity extends through hole walls.
    The cavities can be longitudinal and parallel with respect to the longitudinal axis of the cylindrical body and with respect to the direction of extension of the holes or they can extend transversely with respect to a direction parallel to said longitudinal axis and with respect to the direction of extension of the holes.
    The cavities that extend in parallel with respect to the longitudinal axis and with respect to the holes of the cylindrical body are arranged in intermediate spaces between said holes to reduce the dimensional variations in said intermediate spaces 15 which, if these cavities are not understood, would constitute susceptible areas of contracting or dilating differentially in response to temperature changes.
    The cavities can also extend transversely with respect to a direction parallel to the longitudinal axis of the cylindrical body and to the direction of extension of the holes, being generally practiced in the walls of the holes, that is to say, in walls that separate said holes or in the walls present between the holes and the outer space. These cavities help to avoid or reduce the appearance of cracks in said walls, which generally constitute the parts with a smaller thickness of the cylindrical body and more prone to the appearance of this type of defects due to the dimensional variations of the material. The contours of these 25 cavities would act as structural reinforcement and would constitute limits to the extent of possible cracks in said walls.
    In addition, the cavities facilitate the circulation through them of refrigerant fluid, thus helping the cylindrical body to cool or change
    temperature more uniformly in all its parts, thus avoiding the presence of zones that change temperature at different speeds, which minimizes the dimensional variations of the material.
    Preferably, the polymeric material is resin.
    Optionally, the polymeric material is a material based on polylactic acid. 5
    Advantageously, the cylindrical body is an element produced by 3D printing.
    The polymeric material will preferably be a material suitable for use in a manufacturing process by 3D printing. This manufacturing process allows the production cost of the device of the present invention to be reduced considerably, avoiding the use of molds, the manufacturing of which is very expensive.
    Optionally, the storage device for sample holders of the present invention comprises an integrated sensor.
    Also preferably, the sensor comprises a temperature sensor integrated in the cylindrical body. fifteen
    The incorporation of such a sensor allows monitoring the storage conditions of the samples in the device of the invention during transport or waiting to be analyzed in order to know if the samples may have suffered any deterioration during said period.
    Brief description of the drawings. twenty
    In order to facilitate the description of what has been set forth above, some drawings are attached in which, schematically and only by way of non-limiting example, a practical case of embodiment of the device of the invention is represented, in which:
    Fig. 1 is a perspective view of the cylindrical body of the device of the present invention;
    Fig. 2 is a front elevation view of the cylindrical body shown in Fig. 1;
    Fig. 3 is a view along the cutting line shown in Fig. 2;
    Fig. 4 is a top plan view of the cylindrical body of Fig. 1;
    Fig. 5 is another enlarged perspective view of the cylindrical body of Fig. 1, shown from a different angle; Y
    Fig. 6 shows the cylindrical body of Fig. 5 with a sample holder 5 partially inserted in one of the holes of the cylindrical body.
    Description of a preferred embodiment.
    In Figs. 1-6 shows an embodiment of the sample storage device of the present invention. More specifically, the storage device comprises a cylindrical body 1 made of polymeric material and 10 with a configuration and dimensions that essentially correspond to those of storage devices of the type called Puck, Basket, or Revolver described in section ' Background of the invention 'and that make it compatible with them. Here, "cylindrical body" means any body with a generally cylindrical configuration that may be slightly different from an ideal cylindrical body.
    In the embodiment shown, the cylindrical body 1 comprises 16 holes that completely cross the cylindrical body 1 in a parallel direction with respect to its longitudinal axis L. In Fig. 4 it can be seen that the holes 2 are concentrically distributed around the longitudinal axis L to make better use of the space 20 available in the cylindrical body 1. In this case, the distribution and position of the holes 2 correspond to the standard position of the holes for the sample holders of the Uni-Puck or Universal Puck format described above. .
    The cylindrical body 1 further comprises a central hole 3a and another hole 3b displaced towards the periphery of the cylindrical body 1 which also extend through 25 of the body 1 in parallel with respect to its longitudinal axis L. These holes 3a, 3b have the function of guiding axes of sample holder handling devices (not shown) used for this type of storage device.

    The cylindrical body 1 of the present embodiment also comprises a series of longitudinal cavities 4a and transverse cavities 4b therethrough.
    The longitudinal cavities 4a are arranged in the areas of the cylindrical body 1 located between several holes 2. More specifically, the longitudinal cavities 4a are located in the material areas of the body 1 which, seen in plan, 5 would occupy the largest surface if said longitudinal cavities 4a were not present. The longitudinal cavities 4a extend in parallel with respect to the longitudinal axis L of the cylindrical body 1 a length equivalent to the length of the holes 2.
    As can be seen, the longitudinal cavities 4a have different cross sections 10 depending on the position in which they are located. Specifically, in this embodiment, the longitudinal cavities 4a have cross sections with generally triangular or trapezoidal shapes, with their sides curved inwards, with a complementary contour with respect to the contour of the adjacent holes 2. Also, in some areas between holes 2 (in the more extensive areas 15) longitudinal cavities 4a with a circular cross-section are also present.
    The transverse cavities 4b comprise in the present embodiment a plurality of cavities 4b of circular cross-section extending perpendicularly with respect to a direction parallel to the longitudinal axis L of the cylindrical body 1 and with 20 with respect to the longitudinal extension direction of the holes 2 .
    As can be seen, the transverse cavities 4b are arranged in the walls of the holes 2, forming rows of cavities separated from each other along a line that extends parallel to the longitudinal axis L of the cylindrical body 1 and along of the length of said holes 2. The transverse cavities 25 4b are made in part of the walls that separate adjacent holes 2 or in the walls that separate the holes 2 located closer to the outer perimeter of the outer cylindrical body 1.
    The function of these cavities 4a, 4b will be described later.
     30
    The cylindrical body 1 comprises in its lower part two support rings 6 concentrically arranged around the longitudinal axis L. A support ring 6 has a smaller radius and, seen in plan, its position partially coincides with the interior space of the 16 holes The other ring 6 has a larger radius and is disposed on the periphery of the cylindrical body 1 and, seen in plan, its position partially coincides with the interior space of the 11 most externally located holes of the cylindrical body 1. The function of said Rings 6 will also be explained later.
    In Figs. 5 and 6 show two additional views of the cylindrical body 1 of the device of the present invention in which the function of said device can be observed. 10
    The cylindrical body 1 of the storage device of the invention serves to store sample holders inside, for example, in a low temperature environment (liquid nitrogen), and to subsequently and easily transfer the samples to a device support with a format that corresponds to that of the cylindrical body 1 for the analysis of the samples in an experimental station 15, such as a synchrotron light line.
    The cylindrical body 1 is designed to accommodate in each of the holes 2 a sample holder of circular base type with a rod extending from said base (also described in the section "Background of the invention").
    A support 5 of samples of this type can be seen in Fig. 6. The holder 5 of 20 samples comprises a generally cylindrical metal base 5a with a circular contour having a maximum outside diameter of 12 mm at its lower end (located in Fig. 6 at the top). A rod 5b, usually metallic, is connected at one end to the base 5a and extends parallel to the longitudinal axis of the base 5a and away from it. In some standards the length of said rod is 18 mm. The free end of the rod 5b comprises a sample support element that normally consists of a loop or loop of very small dimensions (or other element, such as a micro mesh, e.g., MicroMesh, etc.) with the one that collects and supports the sample (not visible in the figure). 30
    The sample holder 5 of Fig. 6 also comprises a vial 5c, cap or removable cover that can be attached to the base 5a and that covers the rod 5b when mounted on the base 5a (vial 5c is shown disassembled and separated from the base 5a in Fig. 6 to show more clearly the base 5a and the rod 5b). The vial 5c allows the sample holder 5 to be handled in non-refrigerated environments or that can damage the sample more safely, since the sample is protected from the outside environment by the vial 5c.
    The sample holder 5 would be fully inserted in the corresponding hole 2 with the lower end of the base 5a (located in Fig. 6, in the upper part) arranged at the same height as the mouth of the hole 2 and with the rest of the the base 5a, with the rod 5b, with the sample arranged at the end of the rod 5b and with the vial 5c arranged inside the hole 2. The sample holder 5 is supported with the free end of the vial 5c (the lower end in Fig. 6) in the two support rings 6. The support rings 6 act as a stop, preventing the sample holder 5 from falling through the hole 2 through the lower part of the cylindrical body 1. 15 In this embodiment, the cylindrical body 1 has a suitable length (approximately 44 mm) in order to accommodate the entire sample holder 5 inside each hole 2, so that when the vial 5c is supported on the support rings 6, the base 5a is substantially aligned with the upper face of the cylindrical body 1, that is, at the height of the mouth of the hole 2. Each hole 2 will have a suitable diameter to accommodate each support 5 relatively tightly (preferably, approximately 13.3 mm). The cylindrical body 1 of the present embodiment can accommodate 16 sample holders 5 as shown in Fig. 6.
    Although in the present embodiment the cylindrical body 1 comprises 16 holes in the described arrangement, the cylindrical body 1 could also comprise 10 holes in an arrangement according to the SPINE standard. Likewise, the holes 2 may not cross the entire length of the cylindrical body 1 and be blind. The length of the cylindrical body 1 may also vary.
    As mentioned above, the cylindrical body 1 is made of polymeric material. The cylindrical body 1 will preferably be made by
    A 3D printing process. This type of forming process makes it possible to obtain parts and components with complex shapes at a much lower cost compared to other traditional processes for forming plastic parts (eg, injection molding). Consequently, the polymeric material from which the cylindrical body 1 is formed may be any type of polymeric material 5 suitable for use in 3D printing. The polymeric material may comprise, but not limited to, resins (preferably synthetic resins), polylactic acid (PLA), ABS, nylon, etc.
    The fact of using this type of polymeric material to form the cylindrical body 1 of the device of the present invention implies the appearance of problems 10 not present in the devices made of metal of the prior art. The cylindrical body 1 will be subject to sudden and considerable changes in temperature during use, since frequently the samples it contains should be kept at very low temperatures, of the order of 100 degrees Kelvin (-173 ° C). On numerous occasions, the cylindrical body 1 will be submerged in liquid nitrogen, which means that it goes from room temperature to very low temperatures in a very short time.
    These sudden changes in temperature will cause dimensional variations in the polymeric material more substantial than in the metallic materials. In addition to causing dimensional changes in parts of the cylindrical body 1, creating, for example, problems for a good fit of the supports 5 in the holes 2, such dimensional variations can also cause the appearance of cracks or fractures in the weakest parts of the body 1 (e.g., on thinner walls).
    Cavities 4a and 4b serve to avoid or mitigate the dimensional variations described previously and their effects. 25
    The longitudinal cavities 4a extend in parallel with respect to the longitudinal axis L of the cylindrical body 1. These cavities 4a allow to reduce the thickness of material in areas of the cylindrical body 1 which, in case of not understanding said cavities 4a, would constitute massive or solid areas of material with a thermal inertia greater than that of other parts of smaller thickness of the body 1 and, therefore, 30 with greater dimensional variations than those of the other parts. These areas
    they are essentially the zones between the holes 2, especially the zones between three or more holes 2.
    As can be seen in the figures, the longitudinal cavities 4a can have different cross sections. In the described embodiment, the longitudinal cavities 4a can have a circular section or a complementary section with 5 with respect to the outer contour of the adjacent holes 2. In this way, it is possible to combine longitudinal cavities 4a in different ways to "divide" the solid material spaces between the holes 2 into several cavities 4a.
    The longitudinal cavities 4a allow the cylindrical body 1 to be configured as a plurality of walls essentially with the same thickness (in the described embodiment, approximately 1.2 mm). In this way, the thermal variations to which the cylindrical body 1 will be subjected will essentially affect all its parts in the same way, without dimensional variations due to uneven contraction or dilation in different areas of the cylindrical body 1 due to the presence of considerably different thicknesses in different parts of it. fifteen
    Also, the longitudinal cavities 4a facilitate the passage of refrigerant fluid (e.g., liquid nitrogen) through the cylindrical body 1, thereby allowing more uniform and regular cooling in all areas of the body 1.
    The transverse cavities 4b extend transversely with respect to a direction parallel to the longitudinal axis L of the cylindrical body 1. These transverse cavities 4b cross the walls of the holes 2, more specifically, part of the walls separating adjacent holes 2 or the walls that separate the holes 2 located closer to the outer perimeter of the cylindrical body 1 from the outside. The cavities 4b may be arranged in groups of five or three units, in rows that extend along the length of each hole 2. 25
    The main function of these transverse cavities 4b is to prevent the appearance or extension of cracks or fractures in the walls in which they are arranged due to dimensional variations caused by temperature changes. The contour of the cavities 4b constitutes a limit to the extent of possible cracks that, without the presence of said cavities 4b, would extend a length that could 30
    cover a substantial part of the wall. Likewise, the presence of said cavities 4b also minimizes the appearance of cracks or fractures, since it also helps to uniformize temperature changes throughout the wall.
    On the other hand, the transverse cavities 4b also facilitate the passage of refrigerant fluid through the cylindrical body 1 and into the holes 2, allowing 5 to obtain more uniform and regular cooling in all areas of the body 1.
    The configurations of the cavities 4a, 4b of the device of the present invention may be different from those described in the embodiment shown.
    For example, the longitudinal cavities 4a of the described embodiment are through, that is, they extend along the entire length of the cylindrical body 1 (see Fig. 3). 10 However, said cavities 4a could be non-through and extend a certain length without completely crossing the cylindrical body (blind cavities). The cavities 4a could also comprise closed cavities, that is, cavities not communicated with the outer space and totally surrounded by the material constituting the cylindrical body 1. In addition, the cross-sectional shape of the longitudinal cavities 15 may also be different from that of the cross sections shown. On the other hand, it would also be possible to combine several of the adjacent longitudinal cavities 4a of the embodiment shown in a single cavity.
    The transverse cavities 4b will preferably have a circular cross section. However, they could have a cross section with a different shape if necessary. The number and arrangement of said cavities 4b could also be different from that shown in the described embodiment. The extension direction of the transverse cavities 4b may be different from the directions shown in the embodiment, for example, they could be extended by forming different angles with respect to the longitudinal axis L of the cylindrical body 1. 25
    The storage device of the present invention may include a sensor integrated in the cylindrical body 1 (not shown). Said sensor may comprise a non-electronic or electronic temperature sensor, which allows knowing and monitoring the temperature conditions in which the samples stored in the storage device have been for a certain period of time. Sensor 30
    It can also comprise RFID tags, a thermocouple or other elements to ensure traceability in sample handling.
    It can be seen that the present invention makes it possible to obtain a storage device for sample holders of the type described previously that is made of polymeric material and that allows a much cheaper production than the metal devices analogous to the state of the art and that, thanks to the cavities 4a, 4b described previously, allow to overcome the inconveniences derived from the dimensional variations in this type of material caused by the temperature changes.
    10
    权利要求:
    Claims (10)
    [1]
    1. Storage device for supports (5) of samples of circular base type (5a) with a rod (5b) extending from said base (5a), said device comprising a cylindrical body (1) including a plurality of holes (2) for removably housing said sample holders (5), said holes (2) extending through the cylindrical body (1) in a parallel direction with respect to the longitudinal axis (L) of said cylindrical body (1) ), characterized in that the cylindrical body (1) is made of polymeric material and comprises at least one cavity (4a, 4b) for compensation of dimensional variations in the material caused by temperature changes, said at least one cavity extending (4a, 4b) through said cylindrical body (1).
    [2]
    Device according to claim 1, characterized in that the at least one cavity (4a) extends through the cylindrical body in a parallel direction with respect to the longitudinal axis (L) of said cylindrical body (1).
    [3]
    Device according to claim 2, characterized in that the at least one cavity (4a) is arranged in an intermediate space between several holes (2).
    [4]
    Device according to any one of the preceding claims, characterized in that the at least one cavity (4b) extends in a transverse direction with respect to a direction parallel to the longitudinal axis (L) of said cylindrical body (1) .
    [5]
    Device according to claim 4, characterized in that the at least one cavity (4b) extends through the walls of the holes (2).
    [6]
    6. Device according to any of the preceding claims, characterized in that the polymeric material is resin. 25
    [7]
    7. Device according to any one of claims 1 to 5, characterized in that the polymeric material is a material based on polylactic acid.

    [8]
    Device according to any one of the preceding claims, characterized in that the cylindrical body (1) is an element produced by 3D printing.
    [9]
    9. Device according to any of the preceding claims, characterized in that it comprises an integrated sensor. 5
    [10]
    Device according to claim 9, characterized in that the sensor comprises a temperature sensor integrated in the cylindrical body (1).
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    ES201731129A|ES2657507B2|2017-09-20|2017-09-20|STORAGE DEVICE FOR SAMPLE SUPPORTS|ES201731129A| ES2657507B2|2017-09-20|2017-09-20|STORAGE DEVICE FOR SAMPLE SUPPORTS|
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