• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Procedure for the preparation of a product based on the leaves of the sedum telephium plant for the treatment of infected onychomycosis nails. The procedure consists of stripping the leaves of the sedum telephium plant from the skin of one of its faces, subsequently, the stripped face is impregnated with powdered sulfanilamide and then applied as a dressing on onychomycosis infected nails. It is also used for topical application in the form of cream or ointment on nails infected with onychomycosis. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2652313A1
    申请号:ES201600663
    申请日:2016-08-01
    公开日:2018-02-01
    发明作者:Ángel GONZÁLEZ HERNÁNDEZ；Marta FERNANDEZ LEÓN
    申请人:Ángel GONZÁLEZ HERNÁNDEZ；Marta FERNANDEZ LEÓN；
    IPC主号:
    专利说明:

    Procedure for preparing a product based on the leaves of the Sedum telephium plant for the treatment of nails infected with onychomycosis.  
    5   SECTOR OF THE TECHNIQUE
    The present invention relates to the preparation of a product whereby the infection of the human nail known as onychomycosis is cured.
    10 The main object of this invention is the use of the Sedum telephium plant leaf which together with an impregnation of sulfanilamide in adequate proportion achieves the cure of onychomycosis.
    15 20 BACKGROUND OF THE INVENTION Plasters for the treatment of onychomycosis are already known. For example, W099 / 40955 A describes a patch with pressure sensitive steel die for onychomycosis treatment. This device for treating fungal infections of the toenails and fingernails consists of an occlusive backing layer and a pressure sensitive adhesive matrix layer, where an effective amount of an antifungal agent is dispersed uniformly, optionally with a chemical improver.
    2S 30 Another treatment for treating onychomycosis is described in US546461O A. With that treatment a plaster preparation comprising salicylic acid or a salt, ester or mixture thereof is used. The plaster preparation is connected to and transports the salicylic acid that is present in the plaster preparation in an amount in the range of 10 to 80% by weight of the preparation. Compositions and treatments for nail evulsion and treating infections in the nails and in nail matrices, are described in US5993790 A, where
    claims a topical nail polish composition comprising water-based nail polish, a preservative, urea and a natural additive. This nail polish composition is suitable for treating fungal, yeast and bacterial infections of the nails and nail matrices.
    US 5753256 A describes a plaster for the treatment of nail mycoses, comprising a flexible cover film, a layer of an acrylate polymer matrix, inseparably bonded with the cover film and comprising an active compound selected from miconazole , econazole, isoconazole, thioconazole, terconazole, oxiconazole, ketoconazole, itraconazole, tolcyclate, sulbentin, haloprogin, griseofulvin, cyclopyrox, terbinafine, and salts of these compounds.
    US5181914 A discloses an adhesive gel cushion for treating onyxicosis comprising an occlusive layer, a permeation enhancer and an antifungal agent. US6303140 A discloses a plaster to treat warts, chicken eyes and calluses containing salicylic acid as an active ingredient. US6303140 A also reveals that when the plaster is used to treat onyxicosis, antifungal agents such as clotrimazole, butenaphine, terbinafine or miconazole can be added.
    On the other hand, patents describing the use of plants as curative agents are well known, among them one can mention the Spanish patent ES2104516 of Emeterio Pérez Ruiz in which it patents the use of a plant of the same family and genus ( Crasulácea, Sedum) as requested in this patent. It refers to the use of the juice of the leaves of the Sedum album L plant mixed together with other ingredients and claiming it as an anti-inflammatory lotion. CURRENT TREATMENT OF ONICOMYCHOSIS
    In a publication of the National Health System. Volume 32, No. 3/2008, doctors Larruskain, Idígoras and others, say the following about onychomycosis: Nail infection caused by fungi or onychomycosis (OM) is a very frequent process. Numerous studies from developed countries give prevalence figures between 2-18% of the population. Onychomycosis are nail infections caused by three types of fungi: dermatophytes, yeasts and non-dermatophyte molds. The microbiological diagnosis is essential for its treatment, since this varies depending on the etiologic agent and the type of nail lesion. In onychomycosis caused by dermatophytes, the most frequent and usually affecting the toenails, topical treatment is usually not enough, requiring prolonged oral treatment most of the time. The combination of oral terbinafine and lacquer amorolfine is the therapeutic scheme of choice. In the majority of yeast onychomycosis, which mainly affect the fingernails, lacquers of amorolfine or cyclopyroxolamine are sufficient for healing. Onychomycosis caused by non-dermatophyte molds is uncommon and, to avoid confusion with occasional contaminants, the diagnosis should always be confirmed with two or more positive cultures. Clinical cure is more likely by combining oral and topical treatment.). When it is impossible to perform systemic treatment or health problems arise during treatment and in some opportunistic fungal mycoses, palliative procedures such as the removal of parasitized portions by the fungus can be resorted by partial or total excision of the affected nails. Topical therapy should be considered first because of its limited side effects. There are several antifungal preparations based on imidazoles, allylamines or polyenes. Chemical preparations with antifungal, antiseptic and often keratolytic properties such as benzoic acid, benzoyl peroxide or salicylic acid have also been used, in which there is evidence of their inefficiency. Creams, ointments or solutions do not diffuse well through the nail plate.
    The products especially indicated for the nails are presented in the form of lacquers with which it is achieved that the antifungal is in contact with the nail for a longer time. These doctors continue to say: • "NATURAL" TREATMENTS There is no "natural" method that has proven effective in the treatment of onychomycosis. Some of the supposed curative effects of the homemade methods (washing with vinegar, lotions of plants, etc.) are partly due to the greater attention paid to the care of the nails during these treatments (hygiene, elimination of hyperkeratotic areas, cutting frequent, etc.). B ajoene, an organosulfurized compound obtained from alcoholic extracts of garlic, has an antifungal effect, although there are not enough studies to support its usefulness -In a publication of the editorial Elsevier-magazine-pharmacy-professional -3-pdf13095632-S300 November 2006, doctors Joan Dalmau, Esther Roé and others, say in conclusion: "In large nail hyperkeratosis many authors recommend, in addition to systemic treatment, the use of an antifungal (for example, bifonazole) in combination with nail lacquer urea to improve the penetration of the drug and reduce the nail mass. A controversial issue is the removal of the nail before starting treatment.It is a painful measure that in the various studies analyzed does not provide greater efficacy in the treatment, so only a chemical extraction with 40% urea should be recommended and then topical treatment in those patients who for some reason cannot They give receive systemic therapy. To date there is no therapeutic agent that alone obtains 100% effectiveness. For this reason, the association of a systemic antifungal agent with another in nail lacquer for 3 and 6 months is the most effective treatment for onychomycosis, both feet and hands. EXPLANATION OF THE INVENTION
    It has been unexpectedly discovered that the decarnate use of the Sedum telephium plant leaf together with a sulfanilamide powder solution has very rapid healing properties against nail onychomycosis caused by fungi and yeasts.
    The product obtained by the procedure described is used for direct topical application of the leaves or as a cream or ointment on nails infected with onychomycosis.
    In one embodiment, the invention is as explained below. A leaf of the Sedum telephium plant is separated and the skin is removed from only one of its faces - preferably the beam. Once the leaf has been unloaded, a fine solution of sulfanilamide powder is applied to that surface and then applied to the infected nail by completely covering it, including a few millimeters around it. On the sheet a gauze is superimposed that completely occludes it and on the gauze an adhesive strip or adhesive tape that holds it firmly to the finger around it and must remain so for at least 12 hours in a row.
    If you take advantage of the night, the treatment is more effective since the immobility is convenient to avoid the detachment of the plaster. Once this time has elapsed, the sheet can be replaced if necessary. Depending on the progress of the infection, several days may be necessary, although experience shows that it is not necessary to apply the treatment beyond one week, at which time the infection disappears completely. If the patient needs to move, they can do so, but due to the probable displacement of the plaster, healing can be delayed. If you compare the effectiveness of this treatment with the current ones, its results are amazing, since all studies show that onychomycosis is an infection that is usually very rebellious to current treatments, especially in the elderly or who have diabetes.
    权利要求:
    Claims (2)
    [1]
    1. Procedure for preparing a product based on the leaves of the plant 5 Sedum te / ephium comprising the following stages:
    a) Stripping the skin that protects the Sedum plant leaf from one side
    Telephium
    b) Once the leaf has been unloaded, impregnate it superficially with 10 sulfanilamide powder.
    [2]
    2. Product based on the leaves of the Sedum telephium plant obtained according to the steps of the process of claim 1.
    3. Use of the product according to claim 2 to manufacture a topical medicament for the treatment of nails infected with onychomycosis.
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    同族专利:
    公开号 | 公开日
    CN109562135A|2019-04-02|
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    EP3492092A4|2020-05-20|
    BR112019001952A2|2019-05-07|
    WO2018024923A1|2018-02-08|
    ES2652313B1|2018-09-24|
    US20190167744A1|2019-06-06|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    CN105194121A|2015-10-22|2015-12-30|黄鸿新|External solution for treating onychomycosis|
    WO2012012390A1|2010-07-19|2012-01-26|Marvphyt Development Llc|Botanical composition and methods of manufacture and use|
    US9364510B2|2011-07-19|2016-06-14|Marvphyt Development Llc|Botanical composition and methods of manufacture and use|
    CN102743614B|2012-06-17|2014-01-01|胡桂荣|Preparation method of Chinese medicine irrigation solution for treating pudendum-itching type mycotic vaginitis|CN110151916A|2019-06-24|2019-08-23|刘决梅|A kind of ointment and preparation method thereof for treating onychomycosis|
    法律状态:
    2018-09-24| FG2A| Definitive protection|Ref document number: 2652313 Country of ref document: ES Kind code of ref document: B1 Effective date: 20180924 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201600663A|ES2652313B1|2016-08-01|2016-08-01|Procedure for preparing a product based on the leaves of the Sedum telephium plant for the treatment of onychomycosis infected nails|ES201600663A| ES2652313B1|2016-08-01|2016-08-01|Procedure for preparing a product based on the leaves of the Sedum telephium plant for the treatment of onychomycosis infected nails|
    US16/322,919| US20190167744A1|2016-08-01|2017-07-26|Method for preparing product based on leaves of the sedum telephium plant for the treatment of nails infected with onychomycosis|
    BR112019001952-9A| BR112019001952A2|2016-08-01|2017-07-26|procedure for preparing a product based on the leaves of the sedum telephium plant for the treatment of onychomycosis-infected nails|
    EP17836448.5A| EP3492092A4|2016-08-01|2017-07-26|Method for preparing a product based on leaves of the sedum telephium plant for the treatment of nails infected with onychomycosis|
    CN201780047976.6A| CN109562135A|2016-08-01|2017-07-26|The method of the product of onychomycosis nail of the leaf preparation for treating infection based on Sedum telephium plant|
    PCT/ES2017/000095| WO2018024923A1|2016-08-01|2017-07-26|Method for preparing a product based on leaves of the sedum telephium plant for the treatment of nails infected with onychomycosis|
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