• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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    • 专利摘要:
    Device for controlling blood flow in a blood vessel. The invention describes a device (1) for controlling blood flow in a blood vessel comprising a chain (2) formed by links where the maximum angle of rotation between each pair of links is limited, where the chain (2) has a proximal portion (2p) provided with a loop (3) configured to surround the blood vessel for the purpose of compressing it and a distal portion (2d) configured to close the loop (3) through the application of traction. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2630732A1
    申请号:ES201630066
    申请日:2016-01-20
    公开日:2017-08-23
    发明作者:Carlos Andrés PARDO PARDO；Antonio Ordoñez Fernández；Israel VALVERDE PÉREZ；Sandra Liliana PARDO PRIETO；Juan MORA MACÍAS；Esther REINA ROMO；Jaime DOMÍNGUEZ ABASCAL
    申请人:Universidad de Sevilla；Servicio Andaluz de Salud；
    IPC主号:
    专利说明:

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    DESCRIPTION
    Blood flow control device in a blood vessel OBJECT OF THE INVENTION
    The invention belongs to the medical field, and more particularly to the devices used for the surgical treatment of congenital heart disease in the pulmonary artery.
    The object of the present invention is a new device designed to control the flow of blood through the pulmonary artery by means of the banding technique.
    BACKGROUND OF THE INVENTION
    Within the classification of congenital heart disease there is a typology related to an excessive blood flow in the pulmonary artery, secondary to an incorrect communication of the cardiac chambers. This excessive blood flow causes, over time, a remodeling of the endothelial layer of the arterial wall that ultimately leads to irreversible arterial hypertension. Although it is possible to solve this heart disease by performing a definitive repair surgery, most of the patients are neonates or infants whose weight and size advise against performing a surgical procedure of these characteristics.
    To solve this problem, in 1952 Dr. Muller and Danimann described the banding technique. The banding technique consists mainly of placing a band around the main trunk of the pulmonary artery so that it is constricted, which reduces its internal section and increases the resistance to flow, which finally decreases the blood volume that reaches lungs.
    The banding technique is performed using a medium sternotomy or thoracotomy. Once the pericardium is opened, the pulmonary artery is isolated from adjacent tissues and sufficient space is created to place the band (usually teflon) around the main trunk, which is closed with a stitch. In this way, the flow through the pulmonary artery is limited, which makes it possible to balance the blood volume that reaches the lungs with the systemic blood volume. The correct reduction diameter is valued at
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    operating room by means of arterial oxygen saturation, blood pressure and pulmonary arterial pressure under direct measurement on the main trunk, before and after the band.
    This procedure allows the blood flow to the pulmonary artery to be controlled in a palliative and non-invasive way, avoiding endothelial remodeling, known as the Eisenmenger smdrome, and the poor perfusion smdrome. This allows the definitive repair surgery to be delayed until the patient has gained weight and size.
    However, an important limitation of this technique is that it is not possible to exercise any type of control over the band once the patient's chest has been closed. This is important because the patient's hemodynamic parameters change in the postoperative period, which may even require a new adjustment of the band. In addition, patient growth limits the time of proper functioning of the banding device.
    To solve these problems, recently adjustable banding devices have been developed from outside the thoracic cavity. The Davide del Pozzo document entitled “Hydraulic remotely adjustable pulmonary artery banding”, Proceedings of the 2010 design of medical devices conference, DMD2010, April 13-15, 2010, Minneapolis, USA, provides a summary of different types of adjustable banding devices existing today.
    However, none of these devices has managed to completely solve the problem described, and for this reason they have not been established as devices commonly used by pediatric cardiac surgeons.
    DESCRIPTION OF THE INVENTION
    A first aspect of the present invention is directed to a novel blood flow control device in a blood vessel based on the use of a chain instead of elements such as tapes or the like. It is a chain formed by links where the maximum angle of rotation between each pair of links is limited. This chain has a proximal portion provided with a loop configured to surround the blood vessel for the purpose of compressing it and a distal portion configured to close the loop by applying traction. The user can thus control the diameter of the loop, and in
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    consequently the blood flow through the inner blood vessel to the loop, by applying traction from the distal end of the chain located near the patient's skin outside the thoracic cage. Once it has been achieved that the blood vessel has the desired diameter, the distal end of the chain is fixed to prevent the endoluminal pressure of the vessel itself causing the loop to reopen.
    The use of a chain of the type described instead of elements such as tapes or the like is advantageous for several reasons. In the first place, thanks to the limitation in the angle of rotation between links, it is achieved that to produce a circle a minimum number of links is necessary, each rotated with respect to the adjacent link the maximum allowed angle. This implies that the chain has a maximum curvature that cannot be overcome, which avoids unwanted impingement and irregularities in the compression of the blood vessel.
    In addition, the use of a chain allows to easily reopen the loop. Indeed, if it is desired to increase the diameter of the loop, for example when the patient has increased in size, it is necessary to move a certain chain length in the proximal direction. Normally, the tension caused by the endoluminal pressure of the blood vessel in question causes that, when the fixation of the distal end of the chain is released, a certain length of the same store to move proximally, thus allowing the opening of the loop. However, due to friction or the presence of hooks, sometimes the endoluminal pressure is not enough to open the loop. To solve this problem, if a band or tape were used it would be necessary to reopen the patient to relieve the pressure of the blood vessel, which entailed multiple inconveniences and risks. An important advantage of the use of a chain is that, in combination with a conduit through which it runs, it is possible to "push" it in the proximal direction. Indeed, as links are introduced into the tube from its distal end, said links are they approach each other until they touch, and when all the links inside the tube are in contact with each other it is possible to “push” the chain by introducing more links through the distal end of the tube, which causes the exit of one or several links through its proximal end and allows to achieve the opening of the loop.
    Another advantage more related to the use of a chain is the ease of fixing a traction chain in a given position compared to a band or tape. Indeed, getting the hook or fastening of a link in the chain is very simple, since it is almost impossible for a link to slip or slide from the grip in the way that a band or tape can do.
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    In short, this invention can be applied in general to the control of blood flow in any blood vessel of the patient, although as explained above it is especially indicated for the control of blood flow in the pulmonary artery.
    In a particularly preferred embodiment of the invention, the links that make up the chain are spheres. The use of spheres is particularly useful in this context because a loop formed by a chain of spheres cannot be closed beyond a diameter corresponding to the moment when the spheres come into contact with each other. It is thus possible to limit the angle of rotation between adjacent links of the chain in a simple manner. In addition, the spheres have smooth contours and no edges, which is very suitable in the context of the invention.
    Preferably, the chain comprises a flexible outer coating, for example silicone. This outer coating facilitates the sliding of the chain and also prevents contact with body fluids to affect its properties. As for the chain itself, it can be made of a metallic material. For example, biocomatible and hypoallergenic metal materials such as steel or titanium can be used. In addition, the links in the distal portion of the chain may comprise ultrasound-visible markers that indicate the diameter of the loop. For example, it may be a numbering incorporated into the links by means of a relief.
    In principle, the device of the invention can be configured in any way as long as a chain is used instead of elements such as bands or tapes. However, in a preferred embodiment of the invention the device further comprises a conduit that has a distal end configured to be essentially low to the patient's skin and a proximal end configured to be located next to the blood vessel. This allows the chain to travel through the duct from its distal end to its proximal end, protruding through the proximal end of said duct to form the loop configured to surround the blood vessel. As mentioned, this loop can be closed by applying traction to the chain from the distal end of the duct. In this configuration, the duct serves as a guide for the chain from a peripheral localization close to the patient's skin, from which it is relatively easy to operate the distal end of the chain, to a more internal location adjacent to the vessel whose bloody diameter is controlled . Note that the duct must have sufficient flexibility characteristics to accommodate the patient's tissues in
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    the path between the position of the blood vessel inside the patient where its proximal end will be located and the peripheral position next to the patient's skin where its distal end will be located, and at the same time it should have sufficient consistency to adequately guide the chain along that path.
    The loop can be formed in different ways. For example, it would be possible simply that the proximal end of the conduit had a fixing element for the proximal end of the chain. However, preferably the device of the invention comprises a pin integral with the proximal end of the conduit configured to form the chain loop. The fact that the pin is integral with the proximal end of the conduit only means that relative displacement of one relative to the other is prevented, so that transmission of tensions from the distal end of the chain to the blood vessel is prevented. This is important because the application of traction to said distal end of the chain is prevented from causing a displacement of the position of the blood vessel, which could be dangerous for the patient. For example, the pin could rest on said proximal end of the conduit. In another example, the pin could comprise an essentially cylindrical projection configured to snap fit to the proximal end of the conduit. The pin can be configured in different ways, although it preferably comprises a through hole configured for the passage of the chain and a fixing element for the proximal end of the chain. Thus, the user only has to fix the proximal end of the chain to the fixing element of the pin, then pass the distal end of the chain through the through hole, and finally pull it until the loop has the desired diameter .
    The device of the invention preferably further comprises a storage box connectable to the distal end of the conduit for the storage of a distal portion of the chain. This storage box accumulates a distal portion of chain of sufficient length to provide a sufficient range of variation of loop diameter depending on the position and diameter of the blood vessel whose flow is to be controlled. More preferably, the storage box further comprises a means for fixing the chain in a certain position. For example, the chain fixing means may be formed by a pair of facing projections so that they form a groove configured to engage a link in the chain. Indeed, once the medical professional has applied traction from the distal end of the chain to reduce the diameter of the loop, and therefore the section of the blood vessel, the chain is tense due to the tendency of the blood vessel to recover its original diameter , And because of that
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    it is necessary to fix its distal end. In this example, it is enough to pass a pair of links of the distal portion housed in the storage box respectively on each side of the pair of facing projections so that the chain is immobilized longitudinally. In addition, as will be described in greater detail later in this document, the storage box can be formed by two halves that fit together allowing their union in a hermetic way.
    In principle, the storage box can be connected to the conduit in different ways as long as they are firm enough so that the connection does not separate as a result of normal stresses that occur during the life of the device. In a particularly preferred embodiment of the invention, the connection between the storage box and the conduit is separable. This greatly facilitates the procedure for installing the device, since it is possible to first place the conduit in isolation and then fix it to the storage box. In addition, the fact that the box and the duct are separable allows the duct to be obtained from elements usually found in operating rooms, such as catheters. In fact, the duct can be obtained from at least one section of a catheter of a suitable diameter. As for the length, it is enough to cut a section of the appropriate length depending on the length necessary for each application. This procedure will be described in more detail later in this document.
    More preferably, the connection between the storage box and the conduit comprises an essentially cylindrical projection protruding from an inlet opening of the storage box and which is configured to engage the distal end of the conduit. The connection between the projection and the conduit can be carried out in different ways, such as a thread. Alternatively, the connection can be made under pressure, for example if the essentially cylindrical projection has an external taper that allows the distal end of the conduit to be coupled. Thus, it is sufficient to press the protrusion into the distal end of the duct.
    In a particularly preferred embodiment of the invention, the duct is formed by the combination of an outer duct and an inner duct that projects proximally from said outer duct. This configuration is especially suitable when elements such as catheters are used to form the conduit: an outer catheter of a first diameter can be used for connection with the projection of the storage box, and then introduce an inner catheter of a second diameter
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    smaller than the first diameter in the outer catheter. The reason why an inner catheter of smaller diameter is inserted into the outer catheter is to reduce the inner diameter of the duct so that it fits better to the diameter of the chain and thus prevent it from snagging during use, for example at the end proximal duct or at the edges of the projection connecting to the storage box.
    The use of the described device would be essentially the following. First of all, the duct is placed inside the patient in a position that allows to connect a proximal position where the blood vessel is located whose diameter is to be controlled and a peripheral distal position close to the patient's skin. This operation may require adjusting the length of the duct, for example by cutting it, depending on the needs of each application and particular patient. As described above, it is necessary for the duct to have a certain flexibility in order to accommodate the patient's tissues in the desired position. Once the duct is in position, its distal end is fixed to the storage box by coupling said distal end to the projection provided with an external conicity of the storage box. If necessary, an inner conduit is introduced into the conduit mentioned above, which in that case would be the outer conduit. The chain is then introduced through the distal orifice of the duct until it is expelled from its proximal end. The pin is used to form the loop by passing the proximal end of the chain through the through hole of the pin and fixing said proximal end to a fixing element of said pin. Alternatively, the proximal end of the chain is fixed first to the pin, then this is placed in a position adjacent to the blood vessel, and thirdly the distal end of the chain is passed through the through hole of the pin. In either case, once the loop is formed with the blood vessel located inside, it is only necessary to pull the distal end of the chain until the diameter of the loop, and therefore also the diameter of the blood vessel, is the wanted. The distal end of the chain is then fixed by introducing the corresponding pair of links between the pair of facing projections of the storage box. Finally, the storage box is closed and the incision made in the patient is sutured. The blood vessel is constricted by the chain loop. If it was necessary to act on the chain diameter after a while, for example because the patient has increased in size, it would be enough to make a superficial incision to access the storage box. Once opened, the medical professional only has to remove the two links attached to the pair of facing projections and fix another pair of different links. In this case, if it is assumed that the diameter of the blood vessel has increased as a result of the growth of the
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    patient, the medical professional can reduce the tension allowing the displacement of the chain in the proximal direction under direct vision by ultrasonography. This displacement in the proximal direction can occur by itself due to the endoluminal tension of the blood vessel itself, or it may be necessary for the medical professional to “push” the chain proximally by introducing several links in the tube. On the contrary, if it is necessary to further limit the flow of blood through the blood vessel, the medical professional must pull the chain distally.
    A second aspect of the present invention is directed to a set of parts for the control of blood flow in a blood vessel with the help of a conduit. This set of parts fundamentally comprises:
    a) A chain formed by links where the maximum angle of rotation between each pair of links is limited, which has a proximal end provided with a loop configured to surround the blood vessel for the purpose of compressing it and a distal end configured to close the loop by applying traction.
    b) A storage box connectable to the distal end of the conduit for the storage of a distal portion of the chain, where the storage box comprises an essentially cylindrical projection protruding from an entrance hole thereof and which is configured to engage the distal end of the duct, so that the chain can travel the duct from its distal end to its proximal end and protrude through its proximal end so that it forms the loop configured to surround the blood vessel.
    c) A pin attached to the proximal end of the duct configured to form the chain loop.
    Indeed, this set of parts could be marketed as is, since the user could simply obtain the conduit from one or more catheters usually present in any medical center. You would only have to choose the necessary diameter and cut a section of catheter of adequate length in the operating room itself. Therefore, the procedure for using this set of parts would be identical to the previous one.
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    BRIEF DESCRIPTION OF THE FIGURES
    Fig. 1 shows a sectional view of an example device according to the present invention.
    Figs. 2a and 2b respectively show the lid and the base of a storage box belonging to the example device of Fig. 1.
    Figs. 3a and 3b respectively show an example of a pin belonging to the example of the device of Fig. 1 and a section of said pin along the plane P.
    Figs. 4a and 4b show respectively a chain of spheres in resting position and a chain of spheres tensioned with the maximum curvature.
    Fig. 5 shows an example of a set of parts according to the present invention. PREFERRED EMBODIMENTS OF THE INVENTION
    An example of a blood flow control device (1) in a blood vessel according to the present invention where a chain (2) whose links are spheres is used is described below. Fig. 1 shows a sectional view of said device (1) where the main parts that comprise it are appreciated: chain (2), conduit (4), pin (5) and storage box (8). Next, each of them is described in greater detail.
    Chain (2)
    Figs. 4a and 4b show a chain (2) of spheres respectively in a resting position and a closed position forming a loop of the smallest possible diameter. The chain (2) of spheres is formed by a set of small diameter spheres, for example between 4 French (1.35 mm) and 6 French (2 mm), joined together to form a chain. In this specific example, the diameter of the spheres is approximately 5 French (1.67 mm). As is known, each pair of spheres are connected to each other by means of a small rod whose ends are slidably fixed within the respective spheres. It is, for example, a chain similar to those commonly used for the cap
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    of a bathtub. As can be seen in Fig. 4a, below a maximum curvature the chain (2) of spheres behaves in a manner similar to a tape or band. However, when trying to form a loop of the smallest possible diameter, that is, when trying to increase the curvature of the chain (2), as shown in Fig. 4b, there is a time when each sphere collides with the spheres adjacent and prevents the diameter of the chain (2) of spheres can decrease further. This diameter corresponds to a maximum curvature that cannot be overcome, since, as mentioned earlier in this document, the angle of rotation between adjacent links in the chain is limited. This feature is especially advantageous in the context of the invention, since it prevents pinching in the blood vessel whose diameter is to be controlled.
    The chain (2) of spheres is made of any biocompatible and hypoallergenic material, such as a metal material such as titanium or steel. In addition, a tube (12) of a flexible material such as silicone or the like can be used to cover the conduit and prevent it from directly contacting the patient's tissues. In this example, the silicone coating tube (12) has a diameter of 7 French (2.3 mm).
    Duct (4)
    As mentioned previously, the conduit (4) may in principle be shaped in any way provided that it has a diameter that allows the passage of the chain (2) of spheres inside and that has a flexibility such that it can accommodate it between the patient's tissues but at the same time properly guide the chain (2) of spheres inside without bending or wrinkling. In the example shown in Fig. 1, the duct (4) is formed from two sections of two conventional catheters: an outer duct (4e) and an inner duct (4i). In this example, the outer duct (4e) has an approximate diameter of 14 French (4.7 mm), while the inner duct (4i) has an approximate diameter of 10 French (3.3 mm). The outer diameter of the inner duct (4i) allows its introduction fitted within the outer duct (4e). In addition, the inner duct (4i) protrudes proximally from the outer duct (4e).
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    The use of conventional catheters to implement the conduit (4), either through a single catheter or several that are introduced into each other, constitutes a great advantage of the invention. In effect, this allows medical personnel to choose the most suitable diameter conduit (4) for each case based on the diameter of the chain spheres (2), as well as to cut the length that best fits the patient's size and position of the blood vessel and the storage box (8). If any error occurs, simply take another piece of catheter and perform the operation again, since these are elements usually present in any medical center.
    Pin (5)
    The pin (5) is configured to allow the formation of the loop (3) inside which the blood vessel will be arranged whose flow is to be controlled. For this, in this example a pin (5) is used as shown in Figs. 3a and 3b. This pin (5) has an essentially cylindrical shape with a transverse through hole (6) having a diameter suitable for the passage of the chain (2) of spheres and an element (7) for fixing the proximal end (2p) of the chain (2) of spheres. The fixing element (7) in this specific example adopts the shape of a cavity located in a side wall of the cylindrical pin (5) having a shape configured to receive the sphere located at the proximal end of the chain (2) of spheres . This cavity communicates with a longitudinal hole, displaced relative to the axis of the cylindrical pin (5), which allows the insertion of two opposite screws to immobilize said sphere from the proximal end of the chain (2) of spheres.
    With this pin configuration (5), there is a direct contact between the cylindrical side wall of the pin (5) and the blood vessel itself whose diameter is controlled. This contact causes a deformation of the blood vessel wall that helps modify the endoluminate laminar flow inside, thereby increasing the resistance to blood flow inside and decreasing the need to greatly reduce the diameter of the pulmonary artery.
    Thus, to form the loop (3) it is only necessary to pass the proximal end of the chain (2) of spheres through the transverse through hole (6) and introduce the last proximal sphere (2) into the cavity. Then a couple of
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    screws through the respective ends of the longitudinal hole displaced in communication with the cavity to trap said last sphere. Alternatively, the most proximal sphere of the chain (2) of spheres can be fixed first to the pin (5) with the help of the screws, and then pass the distal end of the chain (2) of spheres through the hole (6) through which the blood vessel is inside the loop (3) formed. In any case, to reduce the diameter of the loop (3) once formed, the medical professional only has to distally distal end of the chain (2), thereby sliding through the hole (6 ) through and decrease the loop diameter (3).
    On the other hand, in this example when the distal end of the chain (2) is pulled distally to decrease the diameter of the loop (3), the pin (5) is supported against the proximal end (4p) of the conduit (4) ). This prevents the tensions from being transmitted, thus preventing the blood vessel inside the loop (3) from being pulled. In this context, it is important that the proximal end (4p) of the conduit (4) is located sufficiently close to the blood vessel so that the pin (5) is at all times supported against the proximal end (4p) of the conduit (4) .
    Storage box (8)
    The storage box (8) serves to store the distal portion (2d) of the chain (2) of spheres. This distal portion (2d) must be of sufficient length to allow different diameters of the loop (3) located in the proximal portion (2p) of said chain (2) of spheres. In addition, the storage box (8) must be completely sealed, since it will be placed under the patient's skin in contact with various body fluids for a period of time that can be quite long, of the order of several months or years. To do this, as seen in Figs. 2a and 2b, the box (8) of this example is formed by a cover (8a) and a base (8b) that fit tightly together. One or more screws or the like can be used for the secure coupling of cover (8a) and base (8b).
    The interior of the base (8b) of the storage box (8) of this example is formed by a pair of cavities (11a, 11b). The cavity (11a) has a size
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    Small and fundamentally it simply consists in the continuation of the entrance hole of the chain (2) of spheres at the base (8b) of the storage box (8). The cavity (11b) has a larger size than the previous one, since it has the function of storing the distal portion (2d) of the chain (2) of spheres. Between the cavity (11a) and the cavity (11b) is located the means (9) for fixing the chain (2) of spheres, which in this example is formed by a pair of projections (9a, 9b) facing each other so that they form a groove that communicates the cavity
    (lla) with the cavity (11b) and which is configured to engage a sphere in the chain (2) of spheres. The groove has a size such that it does not allow the passage of a complete sphere of the chain (2), but the passage of the connecting rod between adjacent spheres of the chain (2). Therefore, to fix the chain (2) of spheres in the desired position the user only has to push down two adjacent spheres so that they are on the respective sides of the groove. The cover (8a) is then placed, whose closing surface is essentially flush with the upper part of the cavities (11a, 11b), so that the upper end of the groove is closed and no sphere can pass from The cavity
    (llb) to the cavity (11a).
    The base (11a) of the storage box (8) also has an outer projection (10) located in the position of the chain inlet hole (2) in the box (8) which has an essentially cylindrical shape although provided with An external conicity. In general, this conicity allows the fixing of the conduit (4) under pressure. More specifically, in the case of this example where the conduit (4) is formed by an internal conduit (4i) and an external conduit (4e), it is the external conduit (4e) that is coupled to the projection (10). Once the outer conduit (4e) has been coupled to said projection (10), the conduit (4i) can be introduced inside it until its distal end is supported against the edges of the projection (10). The inner duct (4i) must also protrude from the proximal end of the outer duct (4e). In this way it is avoided that the spheres of the chain of spheres (2) can catch on the edges of the projection (10) or on the edges of the proximal end of the outer conduit (4e) due to its excessively loose inner diameter for the spheres of the chain (2).
    Finally, Fig. 5 schematically shows a set (10) of parts for the control of
    blood flow in a blood vessel formed by a chain (2) of spheres, a pin
    (5) and a storage box (8), which in this example is formed by a base (8a) and
    a cover (8b). This set (10) of parts can be supplied in a bag or other container for the user to mount the device (1) during the surgical procedure itself, using one or more catheters of a suitable diameter to implement the conduit (4).
    权利要求:
    Claims (18)
    [1]
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    1. Blood flow control device (1) in a blood vessel, characterized in that it comprises a chain (2) formed by links where the maximum angle of rotation between each pair of links is limited, where the chain (2) has a proximal portion (2d) provided with a loop (3) configured to surround the blood vessel for the purpose of compressing it and a distal portion (2p) configured to close the loop (3) by the traction application.
    [2]
    2. Device (1) according to claim 1, wherein the links that make up the chain (2) are spheres.
    [3]
    3. Device (1) according to any of claims 1-2, which further comprises:
    a conduit (4) having a distal end (4d) configured to be essentially low to the patient's skin and a proximal end (4p) configured to be located next to the blood vessel,
    so that the chain (2) runs through the conduit (4) from its distal end (4d) to its proximal end (4p), the chain (2) protruding from the proximal end (4p) of the conduit (4) so that form the loop (3) configured to surround the blood vessel,
    and where the loop (3) is configured to close by applying traction to the chain (2) from the distal end (4d) of the duct (4).
    [4]
    4. Device (1) according to claim 3, further comprising a pin (5) integral with the proximal end (4p) of the conduit (4) configured to form the loop (3) of the chain (2).
    [5]
    5. Device (1) according to claim 4, wherein the pin (5) comprises an essentially cylindrical projection configured to engage the proximal end of the conduit (4).
    [6]
    6. Device (1) according to any of claims 4-5, wherein the pin (5) comprises a through hole (6) configured for the passage of the chain (2) and an end fixing element (7) proximal (2p) of the chain (2).
    [7]
    7. Device (1) according to any of claims 3-6, which also
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    it comprises a storage box (8) connectable to the distal end (4d) of the conduit (4) for the storage of the distal portion (2d) of the chain (2).
    [8]
    8. Device (1) according to claim 7, wherein the storage box (8) comprises a means (9) for fixing the chain (2).
    [9]
    9. Device (1) according to claim 8, wherein the fixing means (9) is formed by a pair of projections (9a, 9b) facing so that they form a groove configured to engage a chain link (2 ).
    [10]
    10. Device (1) according to any of claims 7-9, wherein the connection between the storage box (8) and the conduit (4) is separable.
    [11]
    11. Device (1) according to claim 10, wherein the connection between the storage box (8) and the conduit (4) comprises an essentially cylindrical projection (10) protruding from an inlet opening of the box (8) ) of storage and that is configured to be coupled to the distal end (4d) of the duct (4).
    [12]
    12. Device (1) according to claim 11, wherein the essentially cylindrical projection (10) has an external taper for coupling the distal end (4d) of the conduit (4).
    [13]
    13. Device (1) according to any of the preceding claims, wherein the conduit (4) is formed by the combination of an outer duct (4e) and an inner duct (4i) protruding proximally from said outer duct (4e) .
    [14]
    14. Device (1) according to any of the preceding claims, wherein the chain (2) comprises a flexible outer coating.
    [15]
    15. Device (1) according to claim 14, wherein the outer coating is silicone.
    [16]
    16. Device (1) according to any of the preceding claims, wherein the chain (2) is made of a metallic material.
    [17]
    17. Device (1) according to any of the preceding claims, wherein
    the links of the distal portion (2d) of the chain (2) comprise ultrasound visible markers indicating the diameter of the loop (3).
    [18]
    18. Set (10) of parts for the control of blood flow in a blood vessel with the help of a conduit (4), characterized in that it comprises:
    - a chain (2) formed by links where the maximum angle of rotation between each pair of links is limited, which has a proximal portion (2p) provided with a loop (3) configured to surround the blood vessel for the purpose of compressing it and a distal portion (2d) configured to close the loop (3) by the traction application;
    10 - a storage box (8) connectable to a distal end (4d) of the duct
    (4) for the storage of a distal portion (2d) of the chain (2), where the storage box (8) comprises an essentially cylindrical projection (10) protruding from an entrance hole thereof and which is configured to engage the distal end (4d) of the duct (4); Y
    15 - a pin (5) integral with the proximal end (4p) of the conduit (4) configured to
    form the loop (3) of the chain (2),
    - so that the chain (2) can travel the conduit (4) from its distal end (4d) to its proximal end (4p) and protrude through its proximal end (4p) so that it forms the loop (3) configured to surround the blood vessel.
    twenty
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    同族专利:
    公开号 | 公开日
    WO2017125636A1|2017-07-27|
    ES2630732B1|2018-05-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US1607996A|1925-07-02|1926-11-23|Herbert J W Morgenthaler|Surgical tourniquet|
    US3730186A|1971-03-05|1973-05-01|Univ California|Adjustable implantable artery-constricting device|
    US4069825A|1976-01-28|1978-01-24|Taichiro Akiyama|Surgical thread and cutting apparatus for the same|
    BRPI0505102A|2005-11-22|2007-08-07|Renato Samy Assad|Improvements introduced in pulmonary trunk bandage device|
    US8361093B2|2009-01-23|2013-01-29|Genesee Biomedical, Inc.|Band forming apparatus|
    WO2013018133A1|2011-08-02|2013-02-07|J.Morita Manufacturing Corporation|Pulmonary artery band|
    EP2554139A1|2011-08-05|2013-02-06|Centre Hospitalier Universitaire Vaudois|Actuating device for a surgical implant|
    FR2988287B1|2012-03-26|2017-01-27|Medical Innovation Dev|ADJUSTABLE VASCULAR RING, MEDIUM FOR TREATING THE SFS SYNDROME AND IMPLANTABLE NEEDS COMPRISING SUCH A RING, MOLD AND METHOD OF OBTAINING SUCH A RING|
    US20140236211A1|2013-02-18|2014-08-21|King Abdullah International Medical Research Center|Minimally invasive pulmonary artery band|
    法律状态:
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201630066A|ES2630732B1|2016-01-20|2016-01-20|Blood flow control device in a blood vessel|ES201630066A| ES2630732B1|2016-01-20|2016-01-20|Blood flow control device in a blood vessel|
    PCT/ES2017/070031| WO2017125636A1|2016-01-20|2017-01-19|Device for controlling the flow of blood in a blood vessel|
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