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    abstract patent of invention: "method and apparatus for dermatological treatment". Illustrative methods and systems can be provided for skin renewal which includes the formation of a plurality of small holes, for example, having widths greater than about 0.2 mm and less than 0.7 mm or 0.5 mm, using a mechanical device. Compression and / or tension forces can then be applied to the treated region of the skin as the damage heals to facilitate closure of the hole, and provide improved and / or directional shrinkage of the treated skin area.
    公开号:BR112015000082B1
    申请号:R112015000082-7
    申请日:2013-07-05
    公开日:2020-03-17
    发明作者:Richard R. Anderson；Mathew Avram；Fernanda H. Sakamoto；Wikunda Limpiangkanan；William A. Farinelli
    申请人:The General Hospital Corporation；
    IPC主号:
    专利说明:

    Descriptive Report of the Invention Patent for "SYSTEM FOR PRODUCTION OF A COSMETIC EFFECT ON CUTANEOUS TISSUE".
    Cross Reference to Related Applications [001] The present application refers to and claims priority from U.S. provisional patent application No. 61 / 668,744 filed on July 6, 2012, the description of which is incorporated herein by reference in its entirety.
    Technical Field [002] The present description refers to cosmetic methods and systems for fractional renewal of skin tissue and similar procedures, specifically, such methods and systems that facilitate improved and / or directional reduction in the skin area or reduction of wrinkles .
    Background [003] There is a growing demand for repairs to or improvement of skin defects, which can be induced by aging, sun exposure, dermatological diseases, trauma, surgical procedures, heredity, and the like. The skin loses its tone and smooth texture as it ages, commonly developing wrinkles and laxity. This can additionally be compounded by damage from light and other effects such as, for example, trauma healing, age-related wrinkles, and stretch marks. Aged skin is characterized by a junction between the dermis and the flattened epi-dermis, thinning of the epidermis and dermis, less fibrous glue, and changes in the organization of elastin. Skin rejuvenation therapies work to remove these damaged tissues and / or stimulate the growth of new healthy and elastic fibers in collagen and skin cells and, thus, improve the appearance of the skin.
    [004] The reduction in the appearance of wrinkles is an objective of many dermatological procedures and treatments. For example, a facial suspension operation is a standard surgical procedure in which the skin is removed from the front or back of the ears, which pulls and lifts the adjacent skin on the face and neck that has loosened during aging. However, the result of this procedure is often an unnatural stretched appearance. If the skin on the face and neck itself can be removed in a way that reduces the area of the skin, preferably in one or more directions determined to reduce the area of the skin, without visible scars, the result would be a more natural appearance while still unwanted loose or redundant skin is removed.
    [005] Certain treatments can be used to improve skin defects by irradiating the skin with electromagnetic energy, which can result in beneficial responses to improve the condition of the treated skin. A common procedure for skin rejuvenation, that is, laser renewal, uses light energy to heat and damage the upper dermis. However, laser renewal has a poor side effect profile, with many patients suffering from prolonged erythema, scarring and depigmentation.
    [006] Recently, development and use of fractionated skin therapy has achieved better results. Fractional damage can include the formation of small regions of tissue damage (eg, ablation or thermal damage) that is surrounded by healthy tissue. A small size of damaged regions (for example, usually less than about 1 mm) and the proximity of healthy tissue can facilitate rapid healing of damaged regions, in addition to other desirable effects such as tissue shrinkage. Fractional renewal techniques based on laser and devices involve the use of expensive and potentially dangerous lasers and other sources of intense optical energy to the damaged tissue. Such optical systems can be expensive, present safety hazards, and require a specialized doctor for their operation. In addition, fractional renewal treatments tend to produce a general tightening of the skin that has no preference or directional orientation.
    [007] However, many wrinkles tend to present in certain parts of the body with a general orientation, such as wrinkles that extend laterally from the corners of the eyes or mouth, along the neck below the jaw. Directional skin shrinkage can be achieved by removing elongated areas of the skin in a suitable shape, and then by joining the edges of the remaining skin (for example, with sutures) to "pull" the skin back in a particular direction. Such procedures, as used in conventional facial elevation, create large scars that must be carefully located, and can generate some unnatural-looking shrinkage in response to large-scale removal and skin repositioning.
    [008] It has been proposed to remove smaller parts of the skin, for example, in the order of a few millimeters in width, and to close the resulting holes with sutures or similar to produce a more controlled reduction of the skin area. Such holes must be elongated (for example, of a lenticular or elliptical shape) to facilitate their closure by approaching longer edges and avoiding the formation of dog ears when dismounting. However, such holes are still large enough to produce visible markings when cured, and the total curing time can take up to a few weeks. Additionally, the closure of such holes is a very specialized procedure that can exhibit manipulation such as individual or manual suturing, even approach followed by the application of an adhesive coating such as a cyanoacrylate adhesive to keep the holes closed until they heal. Such puncture closure procedures can be time-consuming and may have a tendency to form visible scars.
    [009] Accordingly, there may be a need for a simple, cheap, robust and safe cosmetic method and system that can be mechanical in nature, and can overcome at least some of the said illustrative deficiencies described above, and that can be configured to produce fractional damage to biological tissue that results in directional reduction of the skin's surface area without causing visible scarring.
    Summary [0010] This description refers to the illustrative modalities of cosmetic methods and systems, simple, inexpensive and safe for the mechanical generation of a plurality of small holes, for example, damage micro-regions, in biological tissue, such as the skin , and for handling the treated skin to generate a cosmetically desirable reduction in the area of the skin that can be improved and / or that has a particular or preferred direction. Such illustrative holes may have a width or diameter that is, for example, between about 0.2 mm and 0.7 mm, or preferably between about 0.2 mm and 0.5 mm as measured along the fabric surface. . Such holes may extend into or preferably through the entire thickness of the dermis. The fractional area of skin removed by the formation of such holes in a treatment region can be between about 5% and 50% or between about 10% and 30%. The formation of holes in this range of size less than a millimeter and area coverage is well tolerated by the body, with a minimal risk of scarring, infection or other complications.
    [0011] An illustrative embodiment of a cosmetic method according to the present description can be provided and may include the formation of a plurality of holes in a region of the skin as described above, and then an application of tension and / or compression tension in a direction usually along the skin's surface to the treated region during the subsequent healing process. Such stresses can improve the overall reduction in the treated region and / or provide directional guidance for the resulting shrinkage. The applied stresses can be maintained in the treated region until the holes have closed substantially and / or the new tissue growth has been effectively modified, for example, between about 4 to 6 days or more. In certain illustrative embodiments, this period of time may be much shorter, for example, on the order of several minutes or hours, if a fabric, glue or similar adhesive is used to facilitate the closure of the hole.
    [0012] In an illustrative embodiment, a pre-stretched or heat shrinkable film can be adhered to the surface of the treated region after the holes are formed. The resulting compression stresses can improve the closure of the hole in the direction of applied stresses and / or affect the orientation of collagen or other structures that grow or evolve as part of a healing response in the tissue surrounding the small holes. A rigid film, plate or other object can optionally be adhered to the stretched film to provide mechanical stability and maintain deformation of the treated region during the primary curing process.
    [0013] In additional illustrative modalities, compression stresses can be generated in the treated region of the skin by applying one or more surgical clips and / or sutures to the area. The staples and / or sutures are preferably large, so that they cover several formed holes, and, optionally, the entire treated region. In certain embodiments, a plurality of staples or sutures can be applied to a single area in different orientations, to provide omnidirectional compression stresses that can improve the hole closure and the overall shrinkage of the treated region compared to a treated region. similar without the applied voltages.
    [0014] In other illustrative modalities, compression stresses can be generated by the application of a shrinkable material to the skin surface after the holes are formed. The shrinkable material may include, for example, a heat shrink film with adhered to the surface of the skin and then heated, a liquid layer that can polymerize or react to form an adherent film that reduces in size as it is formed, cures or it ages, etc.
    [0015] In other illustrative modalities, a photoactivated adhesive can be applied to the surface of the treated region, and a tension or compression can be generated in the region while directing the light energy to the region to activate the adhesive. The light-activated adhesive may include, for example, rose bengal or any other biological light-activated adhesive known in the art.
    [0016] In other additional illustrative modalities, stresses can be generated in the treated region of the skin by stretching the treated region in one or more directions along the skin surface, which can facilitate the closure of the hole and shrinkage in a direction orthogonal to the direction of applied voltage. Such stresses can be generated manually and then maintained, for example, by adhering a rigid film, plate or other object to the stretched area of the skin.
    [0017] According to additional illustrative modalities of the present description, a system can be provided to generate a plurality of holes in a region of the skin that includes one or more nucleus forming needles that can remove small nuclei of tissue by insertion and removal of skin needles. A plurality of such needles can be attached to a substrate to facilitate the movement and positioning of all needles simultaneously. The insertion and removal of the needles can be controlled by an actuator, which can control the positioning of the needles and / or the substrate, if present, through a coupling or mechanical actuation of an electric or pneumatic or similar translation element.
    [0018] The illustrative system may additionally include a compression arrangement capable of or configured to apply a compression device or substance to deform the treated region after the holes are formed therein. For example, the compression arrangement may include a surgical stapler, a suture device, an applicator capable of applying a stretched film or curable / shrinkable liquid to the skin surface, etc.
    [0019] The illustrative modalities described here belong to the cosmetic method and apparatus. It should also be noted that the cosmetic method described here has been tested and is a safe and routine procedure that can be practiced in beauty salons or other facilities. The method presented is a minimally invasive method. In addition, the illustrative method is safe since it does not present a substantial health risk, and does not require professional medical specialization to be performed. No doctor is required to perform the illustrative modalities of the method described here, and little or no risk, much less a health risk, is presented to people being treated with the said cosmetic method if standard hygiene and sterilization procedures are employed , as will be apparent from the description below.
    [0020] Synergistic effects can arise from different combinations of characteristics and modalities described here, although such combinations may not be described in detail. In addition, it should be noted that all the modalities of the present description referring to the method or system according to the illustrative modality of the present description can be performed with the order of steps or procedures as described, however, this need not be the only one order of procedure steps of the method and system. All different orders and combinations of steps and procedures are described here.
    [0021] These and other objects, characteristics and advantages of the present description will become apparent by reading the detailed description below of the illustrative modalities of the present description, when taken together with the attached drawings and claims.
    Brief Description of the Drawings [0022] Objectives, characteristics and additional advantages of the present description will become apparent from the detailed description below taken into consideration together with the attached figures illustrating the illustrative modalities, results and / or characteristics of the present description, where: [0023] Figure 1A is a top view of a round hole that can be formed in the cutaneous tissue, according to the illustrative modalities of the present description;
    [0024] Figure 1B is a top view of a set of holes as shown in Figure 1A;
    [0025] Figure 1C is a top view of an elongated hole that can be formed in the skin tissue, according to additional modalities of the present description;
    [0026] Figure 1D is a top view of a lenticular hole that can be formed in the skin tissue, according to other additional modalities of the present description;
    [0027] Figure 2 is a schematic illustration of a piercing needle that can be used to form small holes in a biological tissue such as the skin, according to the illustrative modalities of the present description;
    [0028] Figure 3A is a schematic side view of a stretched film, according to additional illustrative modalities of the present description;
    [0029] Figure 3B is a schematic side view of the illustrative film illustrated in Figure 3A being applied to the surface of a region of the skin containing holes;
    [0030] Figure 3C is a schematic top view of the skin region illustrated in Figure 2B with the illustrative film applied to its surface;
    [0031] Figure 3D is a schematic side view of the illustrative film applied to the surface of the skin region as illustrated in Figure 3B, with a rigid object adhered to the top of the film stretched to stabilize it mechanically;
    [0032] Figure 4A is a schematic side view of a surgical clip that can be used to compress a region of the skin tissue, according to the additional illustrative modalities of the present description;
    [0033] Figure 4B is a schematic side view of the clip illustrated in Figure 4A that is applied to a region of the skin containing holes in it;
    [0034] Figure 4C is a schematic side view of a tensioning fastener that is applied to a region of the skin containing holes according to certain illustrative modalities of the description;
    [0035] Figure 5A is a schematic side view of a suture that can be used to compress a region of the skin tissue, according to additional illustrative modalities of the present description;
    [0036] Figure 5B is a schematic top view of a plurality of sutures as illustrated in Figure 5A which are applied to a region of the skin containing holes in a first configuration;
    [0037] Figure 5C is a schematic top view of a plurality of sutures as illustrated in Figure 5A that are applied to a region of the skin containing holes in a second configuration;
    [0038] Figure 6A is a schematic top view of a tension being applied to a region of the skin containing holes in it;
    [0039] Figure 6B is a schematic top view illustrating the effect of the stress shown in Figure 6A on the holes;
    [0040] Figure 7 is a schematic side view of an illustrative apparatus for the mechanical generation of fractional damage to the tissue and providing a compressive tension to the tissue, according to additional illustrative modalities of the present description;
    [0041] Figures 8A to 8C are illustrative images of a region of swine tissue taken at various times, illustrating the changes in size and shape that arise from fractional damage generated in it followed by applied stresses; and [0042] Figures 9A and 9B are bar graphs of illustrative data illustrating the changes observed in the width and height of the regions of the porcine tissue damaged in fractional form with nucleus forming needles, normalized by the corresponding size changes of untreated regions. .
    [0043] Throughout the drawings, the same numerical references and characters, unless otherwise mentioned, are used to denote characteristics, elements or similar parts of the illustrated modalities. Similar characteristics can, therefore, be described by the same numerical references, which indicate to the specialized reader that exchanges of characteristics between different modalities can be carried out unless explicitly stated otherwise. Furthermore, while the present description will now be described in detail with reference to the Figures, this is done so that with respect to the illustrative modalities and not limited by the particular modalities illustrated in the Figures. It is intended that changes and modifications can be made to the modalities described without departing from the true scope and spirit of this description as defined by the attached claims.
    Detailed Description of the Illustrative Modalities [0044] Illustrative modalities of the present description refer to cosmetic methods and systems for the generation of a plurality of small holes in the skin tissue and then manipulation or compression of the treated region in a particular direction, which can result in a local directional reduction of the skin surface area without visible scarring.
    [0045] According to the illustrative modalities of the present description, a plurality of small holes 100, such as the hole illustrated in the top view of Figure 1A, can be formed mechanically in the skin tissue, for example, by a core as described in more detail below. The width or diameter of the holes 100 can be between 200 microns and 700 microns, or preferably between 200 microns and 500 microns. The reduced sizes of such holes can prevent the formation of visible marks or scars after the surrounding tissue heals. The formation of holes in this size range is also well tolerated and safe, due to the very small size of the damaged regions formed in the presence of undamaged adjacent tissue to promote rapid healing.
    [0046] The holes 100 can be substantially round as shown in Figure 1A. A plurality of such holes 100 can be formed in a skin treatment region or other tissue, for example, as illustrated in Figure 1B, to promote a general healing reaction across the treated region. Such a healing reaction can, for example, stimulate the contraction of the existing collagen and / or the growth of new collagen in the treated region in response to the mechanical damage generated by the formation of holes 100.
    [0047] For example, holes 100 can be formed using a long hollow needle 200 as illustrated in Figure 2. This illustrative needle 200 has double-ended shanks, and can be formed, for example, by abrasion from opposite sides of the distal end of a hollow needle at an angle relative to the needle's geometric axis. Other needle geometries can also be used, for example, needles 200 having rods with more than two ends. Such a pointed needle 200 (as opposed to, for example, a conventional biopsy needle having a circular cut end) can facilitate the penetration of the needle end 200 into the skin and the removal of small tissue cores to form holes 100 without rotate needle 200. These needles 200 can be formed, for example, from conventional syringe needles having a caliber between about 19 and 27, for example, having an internal diameter between about 700 microns (0.7 mm) and about 200 microns (0.2 mm). Preferably, the needle gauge can be between 21 and 27, corresponding to an internal diameter between about 0.5 mm and about 0.2 mm. Core forming needles 200 can also be formed from other types of hollow tubes having an internal diameter corresponding to the desired hole width.
    [0048] The insertion of needle 200 into the skin tissue, and the subsequent removal therefrom, can remove a tissue core and form a microscopic hole 100. Needle 200 can be inserted to a depth that extends at least partially into the layer underlying dermal, or, preferably, through the entire dermal layer to the underlying subcutaneous adipose layer. Insertion of needle 200 to at least the depth of subcutaneous fat can facilitate removal of the tissue core within the needle lumen of the surrounding tissue, for example, since the tissue core will be cut from the adjacent dermal tissue and the bottom of the core of tissue is not kept strong enough by the underlying fat. Such mechanical core forming procedures used to generate holes 100 may be accompanied by minor bleeding, which is insignificant and may tend to stop quickly due to the small size of the hole.
    [0049] The hole 100 formed by a double-ended needle 200 can be somewhat elongated in shape, as illustrated in Figure 1C. This non-circular shape can result from the stretching of the fabric in a slightly asymmetrical shape and from the cut that can occur when the two points of the needle 200 pierce the fabric and advance within it. For example, the hole 100 formed using a double-pointed needle 200 may have an aspect ratio (for example, length-to-width ratio in cross section) of about 3: 2 on or near the fabric surface. .
    [0050] Other hole shapes can be created according to certain illustrative modalities of the present description, such as a lenticular shape hole 100 illustrated in Figure 1D. For example, the aspect ratio of lenticular hole 100 in Figure 1D can be, for example, about 3: 1, and the angle at which the curved sides meet can be about 30 degrees. This ratio (or a similar appearance ratio) and geometry can facilitate the closure of hole 100 by reducing stresses or associated deformations in the surrounding tissue. Although the shape of a real lenticular hole 100 formed in the soft tissue may not have precisely smooth edges and sharp corners as shown in Figure 1D, an almost lenticular shape can facilitate the closure of such holes 100 as they heal.
    [0051] In general, the specific shapes of the holes 100 may not be important and / or critical, since the small size scale facilitates the approximation of the edges of the hole in any desired direction without generating undesirable effects such as "dog ears" or lack of alignment when they close and heal together. Needles 200 having more tips, for example, 3 or 4 tips, can be used in additional embodiments, where such needles 200 may tend to produce rounder holes 100 such as those illustrated in Figure 1A.
    [0052] In additional illustrative embodiments of the description, the formation of microscopic holes 100 in the fabric that are asymmetrical or non-circular, such as hole 100 illustrated in Figure 1C, may be desirable for generating hole closure 100 that is local and / or macroscopically directional. Such asymmetrical holes 100 can be closed more easily, for example, by compressing the fabric so that the narrow width is further narrowed and opposite sides of the hole 100 are approached or contacted with each other. Asymmetric holes 100 can be formed using a variety of techniques and apparatus in accordance with the modalities of the present description.
    [0053] In an illustrative embodiment, the elongated holes 100 can be formed in the fabric by stretching the fabric in one direction and then forming holes 100 in the fabric, for example, using a mechanical drilling needle 200, or another mechanical device. After allowing the fabric to relax, hole 100 will tend to be stretched in some way, such as hole 100 shown in Figure 1C.
    [0054] In the additional illustrative embodiments, the piercing needle 200 can be provided in various formats, for example, having an elongated non-circular cross section, so that the holes 100 formed in the skin or other tissue by inserting and removing the needle 200 be stretched in shape.
    [0055] In general, the shape of a microscopic hole 100 formed in the soft skin tissue may not have precisely smooth edges and a well-defined shape, and the precise shape of the holes 100 may not significantly affect the subsequent directional shrinkage or the closing behavior due to its small size (for example, 0.7 mm or less).
    The holes 100 can be mechanically formed so that the fraction of the surface area removed in the treated region is between 5% and 50%, for example, between about 10% and 30%. Such fractions of removed tissue area may be small enough to promote healing or recovery of mechanically damaged skin by retaining sufficient healthy tissue around each hole 100, while being large enough to generate a cosmetically desirable amount of shrinkage in a single illustrative procedure performed in the treated region as described here. The fraction of particular area of holes 100 can be selected based on factors such as, for example, the desired extent of shrinkage, the location of the treated region (for example, face, neck, arms, etc.), general skin characteristics , etc.
    [0057] The distribution of holes 100 can be substantially random, or formed in any one of several patterns. For example, a plurality of holes 100 can be formed in the skin or other fabric in a generally square or rectangular arrangement. In additional embodiments, holes 100 may be formed in a set of skewed rows, or in a random pattern. The particular or standard arrangement of the holes 100 may not be particularly important with respect to the shrinkage behavior, for example, due to the large number and small size of the holes 100 in the treated region.
    [0058] A hole pattern 100, as illustrated, for example, in Figure 1B, can be formed using a variety of techniques. For example, holes 100 can be formed mechanically, for example, using an alternating mechanism that passes through the fabric to form the pattern. The mechanism may include one or more rows of core forming needles 200, so that the skewed rows of holes 100 can be generated in the skin tissue. In additional illustrative embodiments, holes 100 can be formed in other patterns that may not be rows, for example, in spatially random arrangements, which can be achieved by repeatedly inserting and removing manually one or more needles 200 at various locations in the treated region .
    [0059] The density or proximity of holes 100 can also vary in different regions of the fabric being treated. For example, the holes can be evenly spaced on the peripheral areas or edges of a particular treated region. Such "feathering" of the volume of tissue removed can facilitate a smoother or gradual transition between the shrunk or tightened skin within the treatment region and the untreated region of the tissue surrounding it. However, such fea-thering or density gradients of holes 100 may not be particularly important for obtaining continuous directional shrinkage across the treated region, since the large number of small holes 100 can adjust to the gradients in skin deformation during the subsequent healing process. For example, the large number and moderate to high density of microscopic holes 100 can accommodate macroscopic gradients in shrinkage with only very small local differences in the closing and curing behavior of each individual hole 100. Such gradients and direction can be produced, for example. example, by illustrative manipulation of the treated region after holes 100 are formed, as described below.
    [0060] The particular shape and size of the treated region in which holes 100 are formed are arbitrary, and can be selected based on the areas of the skin that can benefit from the illustrative methods described here. Such methods can be efficient across both small regions (for example, on the order of cm2 or less) and larger regions, due to the large number of holes 100 less than a millimeter used to achieve the cosmetic effects described here. For example, the small size of the holes 100 generated in a fraction of area between about 5% and 50% can provide a substantially uniform dispersion of such holes 100 when viewed on size scales of about 1 cm or more. Accordingly, the illustrative methods described here can include a directional closure of a large number of small holes 100, which can accommodate any gradients in shrinkage that may result in or adjacent to a particular treatment region and which can be applied to regions of treatment having arbitrary formats and extensions.
    [0061] After the holes 100 are formed in the skin or other fabric, as described above, it is possible to promote the closure of the holes 100 by applying appropriate lateral forces (for example, tension or compression forces) to the fabric in the treated region as it heals. Such forces can facilitate contact between opposite edges of the holes 100, particularly near the fabric surface, and increase the overall shrinkage of the fabric as the holes 100 heal in a closed configuration. In addition, anisotropy and targeting of general skin shrinkage in the treated region following the formation of holes 100 can be achieved by applying such forces in a particular direction during subsequent healing or recovery processes.
    [0062] In an illustrative embodiment of the present description, a stretched film 300 can be used to provide a compressive surface force on the fabric surface in the treated region and to promote the closure of the hole. For example, as illustrated in Figure 3A, the film 300 can be pre-stretched in the direction of the arrows. The stretched film 300 can then be adhered to the fabric surface, as illustrated in the cross-section illustrative of the region treated in Figure 3B. The pre-stretched film 300 can then generate a directional compression force along the fabric surface, as illustrated by the arrows in Figure 3B. This force can pull and join the edges of the holes 100, particularly close to the surface of the fabric to facilitate closing the hole and increased shrinkage of the fabric during the curing process. For example, the stretched film 300 can be applied so that the direction of the compressive forces on the fabric surface (indicated by the arrows in Figure 3B) is in the preferred direction of shrinkage. The hole closure resulting from such compression forces can result in a closed hole configuration similar to the illustrative configuration illustrated in the top view of the treated region of Figure 3C, where the arrows represent the direction of the compression forces, and the small vertical lines 310 represent the approximate edges of the holes 100 on the skin surface.
    [0063] Materials that can be used to form film 300 include Tegaderm ™, another stretchable polymer, or the like. For example, Tegaderm ™ has adherent properties and can be stretched to about 30 to 40% and then applied to the fabric's surface. Other film materials can be used in the additional modalities. Such films can be provided with an adhesive surface, or alternatively they can be adhered to the fabric surface using any suitable biocompatible glue, cement or adhesive.
    [0064] For example, the compression film 300 can be kept on the surface of the tissue for several days, for example, about 4 to 6 days, to facilitate sufficient healing or modification of the skin tissue while being kept in a compressed state, for example, to minimize or avoid the reopening of holes 100 or expansion of collagen in the direction of compression by external forces.
    [0065] In the additional illustrative modalities, a stabilizing film 330 (illustrated in Figure 3D), for example, a non-stretch film, or rigid plate, or the like, can be adhered to the upper surface of the film 300 after having been relaxed and compress the fabric surface. The stabilizing film 330 can provide mechanical stability to the surface of the compressed tissue to maintain the state of compression and to restrict further displacement (eg, relaxation) of the compressed tissue during the curing process, for example, to prevent the relaxation of the film 300 during the recovery process or prevent the release of film 300 from the skin surface. In certain illustrative embodiments, the stabilizing film can be adhered directly to the surface of the skin surrounding the treated region, for example, beyond the edges of the stretched film 300, instead of or in addition to being adhered to the top of the stretched film 300.
    [0066] In another illustrative embodiment of the description, one or more surgical clamps 400 can be used to apply and maintain a compressive force to the treated region, as illustrated in the illustrative cross-sectional views of a treated region in Figures 4A and 4B. An illustrative large surgical clamp 400 (e.g., a clamp large enough to span through a plurality of holes 100) is positioned across the region treated in Figure 4A. Figure 4B illustrates the compression deformation of the region treated by the inserted clamp 400. Illustrative clamp 400 can be used to provide general compression of the treated region of the skin, thereby bringing the edges of a plurality of holes 100 closer together, as illustrated in Figure 4B, instead of approaching two opposite edges of a single incision or wound (as is typically done with conventional surgical staple applications). Such illustrative use of one or more surgical clamps 400 can provide increased compression of the skin under the surface of the treated region compared to that provided by applying a film stretched 300 to the surface of the skin (illustrated in Figure 3B), due to anchorage and joint retraction of the fabric below the surface by clamp 400.
    [0067] In another illustrative embodiment, a tensioning clamp 450 as illustrated in Figure 4C can be used to apply and maintain a compressive tension in the treatment region. The holder 450 includes two-pointed arrangements 460 capable of being inserted into the skin. Tip arrangements 460 may have a sharp point or edge at their distal ends to facilitate penetration into the skin, and may be made of any material sufficiently rigid or strong to withstand tension as described below without significantly breaking or deforming (for example, a rigid metal or plastic or the like). The tip arrangements 460 can be connected by an elastic material 470, which can be supplied as a strip, cord or similar (for example, similar to an elastic, small jump rope or the like). The elastic material 470 can be stretched and the tip arrangements 460 then inserted into the skin within and / or adjacent to the treatment region containing holes formed as described here. The stretched elastic material 470 can then cause the tip arrangements 460 to exert a compressive force between them, as illustrated by the arrows in FIGURE 4C. In this way, a compression stress can be generated and maintained across at least part of the treatment area using a tensioning clip 450 that can be easily inserted and removed from the skin. The size of the tip arrangements 460 and elastic material 470 can be selected based on the size of the treatment region and / or part of that region through which a tension must be maintained.
    [0068] According to certain illustrative modalities, a plurality of clamps 400 and / or tensioning clamps 450 can be applied within and / or across the entire treated region, or a part thereof. In additional embodiments, clamps 400 and / or tensioning clips 450 can be oriented in different directions in or through the treated region to vary the preferred local shrinking direction and / or to provide increased non-directional shrinkage in the treated region (for example, example, compared to a conventional fractional damage procedure that does not compress the treated region after holes 100 are formed).
    [0069] Staples 400 and / or tension clamps 450, if used, can be retained in the treatment region for several days, for example, about 4 to 6 days, to maintain a state of compression during the curing process / recovery, thus allowing sufficient healing or modification of the skin tissue while being kept in a compressed state. In addition, clamps 400 and / or tension clamps 450 can be small or thin in at least one direction, to avoid the formation of visible marks after their removal. In certain illustrative embodiments, clamps 400 and / or tensioning clamps 450 can be used which are thin and / or include several points configured to pierce the skin. Such clamps 400 and / or tension clamps 450 can provide compressive forces comparable with a single large clamp 400 or clamp 450 while allowing individual tips to be smaller in size to reduce or eliminate the formation of marking when such clamps 400 and / or 450 tensioning prongs are removed.
    [0070] In another illustrative embodiment of the description, one or more sutures 500 can be applied to the treated region to maintain a compressive force thereon, as illustrated in the illustrative cross-sectional view of Figure 5A. Each suture 500 can be large enough to cover a plurality of holes 100, thereby promoting the directional approach of opposite surfaces of the holes 100, as illustrated in Figure 5A. Similar to staple 400 illustrated in Figure 4B, suture 500 can provide increased compression of the skin below the surface of the treated region compared to that provided by applying a stretched film 300 to the surface of the skin.
    [0071] According to certain illustrative modalities, a plurality of sutures 500 can be applied within and / or across an entire treated region, or a part thereof. For example, a plurality of sutures 500 can be applied substantially parallel across the treated region, as illustrated in the top illustrative view of Figure 5B. The arrows in Figure 5B indicate the direction of the compression forces, and the small vertical lines 310 represent the approximate edges of the holes 100 on the skin surface. In another illustrative embodiment, sutures 500 can be applied in different directions across the treated region, such as in the illustrative configuration illustrated in the top view of Figure 5C, to provide increased non-directional shrinkage of the treated region. The arrows in Figure 5C represent the local direction of the compression forces, which may tend to compress the edges of the holes 100 in the skin surface in an omnidirectional or isotropic manner. In another illustrative embodiment, sutures 500 can be oriented in different directions within or through the treated region to vary the preferred local direction of shrinkage within the treated region.
    [0072] Similar to stretched film 300 and staple 400, sutures 500, if used, can be retained in the treatment region for several days, for example, about 4 to 6 days, to maintain a state of compression during the process healing and recovery, thus allowing sufficient healing or modification of the skin tissue while being kept in a compressed state.
    [0073] According to the additional illustrative modalities, other devices and techniques can also be used to apply and maintain compressive forces to the perforated tissue in the treated region such as, for example, forceps, adhesive heat shrink films, surface application. of curable liquids such as polymeric precursors that can shrink and adhere to the skin's surface as they heal, etc. Any heat shrink film, curable shrink liquids, and the like that are known in the art can be used with certain embodiments of the present description.
    [0074] In additional illustrative modalities, any combination of stretch film 300, staples 400, sutures 500, heat shrink films and / or curable liquids can be used to apply and / or maintain stresses or deformations in the treated region as holes 100 heal.
    [0075] According to other illustrative modalities, a tension force can be applied to a surface region of the fabric to promote the closure of the holes 100 formed therein. For example, a plurality of holes 100 can be formed in a fabric as described here and illustrated in Figure 6A. A tension force can be applied to the tissue in the direction of the arrows shown in Figure 6A. Such an illustrative tension force can locally stretch the fabric in the direction of the arrows, which can cause the sides of the holes to approach and / or contact each other as illustrated in Figure 6B. Such narrowing of holes 100 can facilitate closure and healing, and result in a local directional shrinkage of the fabric in an orthogonal direction to the applied tension force as the holes heal, while tending to maintain or even slightly expand the skin in the direction of tension forces as tissue damage caused by the formation of holes 100 heals.
    [0076] The tension force, as illustrated in Figure 6A, can be applied using any one of a variety of techniques and / or devices. For example, such force can be applied manually, for example, by pressing dice against the skin on opposite sides of the treated region, adjacent to its perimeter. The fingers can then be spread out to apply the tension force to the tissue, for example, to stretch the region of the tissue between the contact points of the fingers. A non-stretch or rigid adhesive film or plate can then be adhered to the stretched fabric to inhibit or prevent relaxation of the fabric as the holes heal, thereby maintaining the fabric in a stretched or strained state. In an additional embodiment, an expansion device can be used including two or more contact surfaces that can be spread, for example, a pair of forceps or the like having a flat contact area at the end of each tip. In a similar way, the contact areas can be pressed against the fabric and then moved mechanically to stretch the fabric between the contact areas. Contact areas can be provided with a rough, non-slip and / or adhesive surface to maintain contact with particular locations on the skin or fabric surface as tension force is applied, and the expansion device can be configured to keep the configuration expanded while sticking to the skin surface. Other techniques for stretching the skin locally can also be used with modalities of the present description.
    [0077] Various additional procedures can be used to promote the closure and healing of the hole of the holes 100 after they are formed in the fabric. For example, holes 100 may be exposed to saline or other solutions after being formed, to promote hydration and softening of the tissue prior to curing. Such solutions can also facilitate the removal of residues or impurities in the holes, for example, removal of blood which may be present after the holes 100 are mechanically formed using one or more core forming needles 200.
    [0078] In additional illustrative modalities, biocompatible glues or adhesives can be used to facilitate faster adherence of closed holes 100, for example, during the curing process. For example, photomechanical tissue bonding (PTB) techniques can be used to help fix holes 100 in a closed configuration during the curing process. In a PTB process, a photosensitizer (eg, rose bengal, riboflavin, porphyrins, chlorine, and the like) can be applied to the fabric after holes 100 have been formed in it, but before applying the compression film 300 or a force of compression or tension as described here. Photosensitizer precursors including, for example, prodrugs of such photosensitizers, can also be used, where such precursors can be metabolized or otherwise activated to form photosensitizers in tissue. Such photoactive substances (for example, photosensitizers or precursors) can promote tissue bonding when applied to the tissue, optionally activated or metabolized, and then exposed to light having one or more suitable wavelengths.
    [0079] After the holes 100 are directionally compressed using stretched film 300, staples 400, sutures 500 and / or forces of compression or tension, the fabric can be exposed to light having a wavelength suitable for activating the union of fabric, to promote the adhesion of the walls of the hole within few minutes. The choice of wavelength can be based on the particular photosensitizer or precursor used. The material and / or objects imposing forces of compression and / or tension on the treated region can be removed while the holes 100 remain closed on the fabric surface and continue to heal.
    [0080] According to other illustrative modalities, the stretched film 300 can be supplied with a layer of one or more photosensitizers or precursors, so that at least a part of the photoactive substances is transferred to the surface of the fabric when film 300 is applied to the fabric surface. For example, photoactive substances can be supplied in a gel layer or microencapsulated layer on the surface of the film 300 which is located against a surface of the skin. The activation light can then be directed through the top surface of the film 300 and the compressed tissue surface and the applied photoactive substance. In general, one or more of the several conventional photochemical fabric bonding systems, materials and methods can be used to facilitate faster hole closure in accordance with the modalities of the present description.
    [0081] In additional illustrative embodiments, other fabric glues such as, for example, cyanoacrylate, can be used to glue holes 100 together after being formed and compressed, stretched and / or closed. It may be preferable to limit the application of such glue to the fabric surface and to avoid introducing it into the holes 100, to avoid filling them with undesirable material which can inhibit the subsequent closing and shrinking of the hole. The use of any conventional fabric bonding technique or fabric adhesives, including those described here, can reduce the amount of time that the compression film 300 or other coatings are kept on the treated fabric area as it cures, while curing. prevents the re-opening of closed holes 100 during the gradual curing process.
    [0082] As described here, the shape, density or spacing and the pattern or spatial distribution of the holes 100 and / or the orientation of a compressive force or tension applied to the surface of the treated region, can provide a shape-oriented shrinkage directional direction of the fabric as it heals. Such targeting can be used to achieve improved cosmetic results by generating increased shrinkage in a preferred local direction in a mechanical fractional renewal procedure. A plurality of such procedures can be applied to a particular treated region to obtain greater general shrinkage of the skin or other tissue, preferably allowing sufficient curing time between subsequent treatments of a particular area. The directions of compression and / or tension may vary in different treatments of a single area to obtain a more homogeneous shrinkage of the tissue in the area. The preferred shrink sizes and directions of the adjacent treated regions can also be selected and varied to achieve desirable general shrinking patterns for the skin or other tissue.
    [0083] The application of a tension or compression force to the fabric to promote the closure of the hole can also affect the characteristics of the glue that can be formed during the hole closing and curing processes of the fabric that occur after the holes 100 have been formed. For example, collagen can grow and / or align in particular directions upon formation in the tissue that is deformed by the application of external forces after the formation of holes 100, as described here. Such modification of the collagen growth and / or alignment in the treated tissue can provide additional desirable cosmetic effects.
    [0084] In the additional illustrative embodiments of the present description, a system can be provided to generate a plurality of fuels 100 in a treated region of the skin, and then apply a compressive force or tension to the treated region. For example, an illustrative system 700 can be provided and includes a handpiece 710 having a bottom surface 715, a plurality of retractable core forming needles 200, a trigger handle 720, and a compression arrangement 730, as shown in Figure 7. Needles 200 can, for example, be attached to a mobile substrate 725 as a set of needles or similar to facilitate their controllable movement and positioning relative to the bottom surface 715. According to certain illustrative modalities, needles 200 and the substrate 724 can be supplied together as a single unit or cartridge, which can be disposable or reusable / sterilizable. The bottom surface 715 can be configured and / or structured to be located on the surface of a treated region, and the trigger handle 720 may be able to position and / or hold needles 200 and / or substrate 725 in one or more locations with respect to the bottom surface 715.
    [0085] A number of needles 200 and area of the needle set can be selected based on several factors. For example, a number of needles 200 may be large enough to facilitate rapid treatment of large areas of the skin, but not so large that the cost and complexity of the needle set becomes prohibitive. In addition, it may be difficult to insert a large number of 200 needles into the skin simultaneously. For example, such a number of needles 200 can be between, for example, 1 and 50, or between about 6 and 25. In certain illustrative embodiments, a greater number of needles 200 can be provided in the 700 system. The average spacing between the needles 200 can be selected based on the inner diameter of needles 200 and the desired fractional area of the skin to be removed by a single insertion and removed from needles 200, using simple geometric calculations.
    [0086] In an illustrative configuration, the system 700 can (for example, initially) be configured so that the distal ends of the needles 200 project at a particular distance below the bottom surface 715. Such an illustrative distance can be, for example, the approximate depth of the local dermis of the treated region. In certain embodiments, such a distance can be adjustable (for example, using a screwed or stopping adjustment element, a plurality of staggered or similar configurations, not shown) so that the system 700 can be used to treat the skin having various thicknesses.
    [0087] The illustrative system 700 can be applied to a treated region until the bottom surface 715 of the system 700 contacts the surface of the skin, so that the needles 200 penetrate the skin tissue up to a particular distance within the skin , for example, across the entire thickness of the dermis. The trigger handle 720 can then be tightened to retract the needles from the skin by pulling the distal ends of the needles 200 above the bottom surface 715 and forming a plurality of holes 100 in the skin. The trigger handle 720 may additionally be able to activate the compression arrangement 730 (not shown) to apply a compression element to the treated region after the needles 200 have been removed from the treated region.
    [0088] In an illustrative embodiment, the compression arrangement 730 may include a surgical stapler configured to be mechanically or electrically driven by the handle of the driver 720, so that tightening the handle of the driver 720 first removes the needles 200 from the treatment site and then apply one or more large clamps 400 and / or tension clamps 450 through at least a part of the region treated as described above.
    [0089] According to another illustrative embodiment, the compression arrangement 730 may include a suture needle (e.g., a curved needle) and a suture thread. The compression arrangement 730 may be capable of or configured to introduce one or more lengths of suture below the surface of the treated region, for example, with the ends of the thread protruding from the skin surface, when it is triggered by the handle of driver 720, after needles 200 are removed from the treatment site. The ends of the suture thread can then be tied together to form a suture 500 that can apply a compressive force to the skin tissue in the treated region as described above. Optionally, the compression arrangement 730 may be capable of or configured to untie the suture when activated, for example, at a pre-selected tension.
    [0090] In another illustrative embodiment, the compression arrangement 730 may include a stretched film applicator that can and / or is configured to adhere a stretched film 300 or the like through the treated region after the needles 200 are removed from the skin. For example, the compression arrangement 730 may include a small roll of stretched film 300 configured similarly to a packaging tape dispensing apparatus. The system 700 can be transferred through the treated region after the needles 200 are removed to apply the film 300 over the newly formed holes 100. Film 300 can also be supplied in pre-cut pieces that are sized to fit over the treated region.
    [0091] According to an additional illustrative embodiment, the compression arrangement 730 may include a reservoir of curable coating material, as described above, and may be able to apply such coating material to the surface of the treated region after the needles 200 are removed from the skin. In another embodiment, the compression arrangement 730 can be configured or adapted to apply a photoactivated material (or precursor of such material), as described above, to at least part of the treated region, and directing the light energy to the region to activate the material. The modalities of the system 700 in which the compression arrangement 730 can apply other types of compression or tensioning elements to the treated region after the holes 100 are formed are also within the scope of the present description.
    Example [0092] An illustrative procedure in accordance with certain illustrative modalities of the present description was carried out on the lower abdomen of a swine animal model to demonstrate the ability to produce directional shrinkage. Six test sites, each approximately 3 cm by 3 cm square, were tattooed on the animal on Day 0. Seven control sites of the same size were also marked between the test sites. Control sites were included to compensate for the animal's net growth through the course of observations.
    [0093] For example, 144 evenly distributed holes were drilled through the depth of the skin at each test site using a specially designed vacuum-assisted 19 gauge piercing needle. The holes were formed in a substantially random set by manually inserting and removing the drill needle 144 times at arbitrary locations within the test sites. The width of the holes formed was approximately equal to the inner diameter of the needle, for example, about 0.69 mm. This corresponds to a removal of fractionated surface area within each test site of about 6%. This corresponds to a relatively low fractional amount of skin tissue removed within the preferred ranges described here.
    [0094] A pre-stretched adhesive coating (Tegaderm ™) was then adhered to the test sites and allowed to retract towards its original size, thereby compressing the fabric as described above. Test sites 1, 2, 4, 5, and 6 were compressed along Langer lines that run approximately horizontally from head to toe (for example, in the X direction). Test site 3 was compressed using Langer lines (in the vertical or Y direction). No stretched film was applied to the seven control sites.
    [0095] The coating was left in place at each test site for seven days and then removed. The animal was observed, photographed and the width and height of each test and control site were measured until the 28th.
    [0096] Photographic images of test site 6 taken on Day 0 (pre-treatment), Day 7 (when the liner was removed), and Day 28, were illustrated in Figures 8A, 8B and 8C, respectively. The sizes of these images have been adjusted so that the ruler length is the same in each. The overall shape of the test site changed from substantially square to rectangular from Day 0 to Day 28, with the width of the test site (in the direction of compression, along the Langer lines) being about 12% smaller in the end of the observation compared to the initial size of the test site. The height of the test site (orthogonal to the direction of compression) increased by about 17% by Day 28 compared to the pretreatment height Day 0. Additionally, no apparent scar or mark is evident in these images, consistent with the advantages cosmetics expected to reduce skin area by forming many very small holes.
    [0097] Table 1 below illustrates the measured width and height (X and Y, respectively) of each test site on Day 0, Day 7 and Day 28. The data suggests that the width of sites 1, 2, 4, 5 and 6 decreased slightly through the course of observations, and they tended to widen slightly between Day 7 (when the compression liner was removed) and Day 28, which can be partially attributed to relaxation of unrestricted skin. The width of test site 3 increased between Day 0 and Day 7 as this site was compressed in the vertical direction, orthogonal to the other test sites. Similarly, the height of the test sites (except for site 3), orthogonal to the direction of compression, appears to have remained quite the same or increased slightly between Day 0 and Day 20.
    Table 1: Measured dimensions of each test site (in cm.) On Days 0, 7 and 28 [0098] It should be noted that there is some net growth of the animal subject through the course of the observations. To correct this, the width and height of each control location were measured on Day 0, 7 and 28. The measured width and height of each test location were then normalized by the average width and height, respectively, of the measured control locations. on the same day. This provides an approximate correction of the overall growth of the animal (ie, overall increase in the area of the skin) between measurements of the test site dimensions. Table 2 below includes the width and weight of each control location measured on Days 0, 7 and 28.
    Table 2: Measured dimensions of each control site (in cm), on Days 0, 7 and 28 [0099] Bar graphs illustrating the standardized width and height (X and Y, respectively) of each test site are illustrated in the Figures 9A and 9B, respectively. The data in these graphs suggests that there is a noticeable reduction in the width of test sites 1, 2, 4, 5, and 6 over 4 weeks following the initial treatment, when the overall growth of the animal has been compensated. There also appears to be a slightly less marked reduction in the height of these test sites (orthogonal to the direction of compression) during the same period. Thus, there seems to be some preferred direction in the test subject's skin shrinkage when treated according to the modalities of this description.
    [00100] The observed effects (and differences in behavior between the X and Y directions) are somewhat more modest in this illustrative study. Few factors should be noted when determining these measured results. First, there are qualitative differences between human and porcine skin. It is expected that human skin, being thinner and less resilient, may be more affected under similar treatment conditions. Second, the fractional area of skin removed in each test area was only 6%, which is relatively low. More marked results are likely to appear if a greater number of fusions are formed within each test area (corresponding to a greater fraction of the skin removed, for example, up to 25 to 30% or more). In addition, the coating has not always adhered very well to the animal's skin, and tends to adhere more strongly to human skin, thus providing more efficient compression forces. Additionally, the net growth of the animal during the observation period, although addressed in the data analysis, can still affect the normalized results. Such "liquid growth" effects would not typically be present in mature human patients, so that real skin shrinkage can be greater and associated directional differences may be greater. Summary [00101] It will be appreciated that those skilled in the art can envision numerous systems, arrangements and methods that, although not explicitly illustrated or described here, embody the principles of the description and are, therefore, within the spirit and scope of this description. In addition, all publications, patents and patent applications referred to herein are hereby incorporated by reference in their entirety.
    权利要求:
    Claims (8)
    [1]
    1. System, characterized by the fact that it comprises: at least one piercing needle (200) structured to form a plurality of holes (100) in a region of the skin tissue; and a compression arrangement (730) configured to produce and maintain a compression tension across the region after the holes (100) are formed, wherein the compression arrangement (730) is configured to: adhere a pre-stretched film to at least at least a portion of the skin area, apply a curable or shrinkable liquid to the skin surface; adhere a rigid material to at least a portion of the tensioned skin region, or apply at least one staple or suture to or adjacent to the skin region, where an internal diameter of at least one piercing needle (200) is between 0.2 mm and 0.7 mm, in which at least one needle is capable of forming or structured to form the holes (100) extending from the cutaneous surface in the dermal layer of the skin, and in which the compression arrangement (730) is configured to maintain the tension that provides a force in the region along a direction that is substantially parallel to the skin surface until the holes (100) have substantially closed.
    [2]
    System according to claim 1, characterized in that the at least one needle comprises a plurality of needles (200).
    [3]
    System according to claim 1, characterized by the fact that the internal diameter of at least one piercing needle (200) is greater than 0.2 mm and less than 0.5 mm.
    [4]
    4. System according to claim 1, characterized by the fact that the holes (100) extend over a fraction of the surface area of the skin tissue region that is about 5%.
    [5]
    5. System according to claim 1, characterized by the fact that the holes (100) extend over a fraction of the surface area of the skin tissue region that is about 10%.
    [6]
    6. System according to claim 1, characterized in that the at least one needle is structured to form the holes (100) that extend from the cutaneous surface through the entire dermal layer of the skin.
    [7]
    7. System according to claim 1, characterized by the fact that the holes (100) are evenly distributed.
    [8]
    8. System according to claim 1, characterized by the fact that it also comprises a vacuum fixed to the drilling needle (200), in which the vacuum assists the drilling needle (200) to form the holes (100).
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    同族专利:
    公开号 | 公开日
    AU2018203245A1|2018-05-31|
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    WO2014008470A9|2014-07-31|
    AU2013286576A1|2015-01-22|
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    US20220054343A1|2022-02-24|
    US20150173991A1|2015-06-25|
    HK1210978A1|2016-05-13|
    WO2014008470A1|2014-01-09|
    ZA201900021B|2021-03-31|
    TWI581753B|2017-05-11|
    RU2649469C2|2018-04-03|
    JP2015522351A|2015-08-06|
    JP2018143819A|2018-09-20|
    AU2013286576B2|2018-03-08|
    CA2878458A1|2014-01-09|
    SG11201500075WA|2015-02-27|
    ZA201800043B|2019-04-24|
    TWI629044B|2018-07-11|
    RU2015103835A|2016-08-27|
    KR20150036389A|2015-04-07|
    TW201731463A|2017-09-16|
    AU2018203245B2|2019-11-28|
    US20180008500A1|2018-01-11|
    BR112015000082A2|2017-06-27|
    EP2872222A1|2015-05-20|
    CA2878458C|2020-08-18|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US6178346B1|1998-10-23|2001-01-23|David C. Amundson|Infrared endoscopic imaging in a liquid with suspended particles: method and apparatus|
    WO2001085035A2|2000-05-10|2001-11-15|Canica Design Inc.|System and method for moving and stretching plastic tissue|
    US20080183162A1|2000-12-28|2008-07-31|Palomar Medical Technologies, Inc.|Methods And Devices For Fractional Ablation Of Tissue|
    US20030091665A1|2001-11-09|2003-05-15|Avon Products, Inc|Topical cosmetic composition with skin rejuvenation benefits|
    US6908453B2|2002-01-15|2005-06-21|3M Innovative Properties Company|Microneedle devices and methods of manufacture|
    US20060155266A1|2003-03-27|2006-07-13|Dieter Manstein|Method and apparatus for dermatological treatment and fractional skin resurfacing|
    US8535299B2|2004-01-23|2013-09-17|Joseph Giovannoli|Method and apparatus for skin reduction|
    RU2325859C2|2004-03-15|2008-06-10|Марлен Андреевич Суламанидзе|Surgical suture and method of cosmetic operation performance|
    EP1726317B1|2004-03-15|2012-07-04|Marlen Andreevich Sulamanidze|Surgical means for cosmetic surgery|
    ES2293128T3|2004-07-09|2008-03-16|JOHNSON & JOHNSON GMBH|COSMETIC COMPOSITION FOR DESMAQUILLAR AND APPLICATOR THAT INCLUDES SUCH COMPOSITION|
    US9486274B2|2005-09-07|2016-11-08|Ulthera, Inc.|Dissection handpiece and method for reducing the appearance of cellulite|
    WO2007066339A1|2005-12-07|2007-06-14|Ramot At Tel Aviv University Ltd.|Drug-delivering composite structures|
    ES2529546T3|2006-04-07|2015-02-23|The General Hospital Corporation|Apparatus for producing a thermal lesion on the skin|
    RU61559U1|2006-06-06|2007-03-10|Марият Мурадалиевна Мухина|NEEDLE FOR NEEDLE-REFLEXOTHERAPY |
    CN103494620B|2006-08-03|2016-04-20|利兰斯坦福青年大学托管委员会|Be used for the treatment of or prevent the equipment of scar and/or cicatrix and binder and method thereof and external member|
    WO2008052189A2|2006-10-26|2008-05-02|Reliant Technologies, Inc.|Micropore delivery of active substances|
    TW200841866A|2007-04-25|2008-11-01|Micro Base Technology Corp|Cosmetic or medical patch structure|
    GB0719037D0|2007-09-28|2007-11-07|Vitrolife Sweden Ab|Sampling needle|
    KR101912816B1|2008-04-01|2018-10-29|더 제너럴 하스피탈 코포레이션|Apparatus for tissue grafting|
    JP2011530349A|2008-08-07|2011-12-22|ザジェネラルホスピタルコーポレーション|Method and apparatus for skin hypopigmentation|
    IT1394690B1|2008-10-23|2012-07-13|Carli De|METHOD OF DERMOCOSMETIC TREATMENT OF THE SKIN WITH THE APPLICATION OF COMPOSITIONS CONTAINING NGF.|
    EP2552323A4|2010-03-29|2013-09-25|Follica Inc|Combination therapy|
    WO2011140497A2|2010-05-07|2011-11-10|The General Hospital Corporation|Method and apparatus for tissue grafting and copying|
    WO2011163264A2|2010-06-21|2011-12-29|Candela Corporation|Driving microneedle arrays into skin and delivering rf energy|
    CA3042411A1|2011-01-28|2012-08-02|The General Hospital Corporation|Method and apparatus for skin resurfacing|
    US8523849B2|2011-02-03|2013-09-03|Tria Beauty, Inc.|Radiation-based dermatological devices and methods|
    US20120226306A1|2011-03-03|2012-09-06|Jasper Jackson|Controlled strain skin treatment devices and methods|
    CN102178616B|2011-05-06|2013-06-05|广州保税区雅兰国际化妆品有限公司|Hyaluronic acid micro-needle adhesive film and preparation method thereof|
    CN202113484U|2011-05-23|2012-01-18|苏州东邦医疗器械有限公司|Module for skin resurfacing|
    US20130110026A1|2011-07-27|2013-05-02|Neodyne Biosciences, Inc.|Strained skin treatment devices and methods|US20180344343A1|2010-12-17|2018-12-06|Edward KNOWLTON|Pixel array medical systems, devices and methods|
    US10661063B2|2010-12-17|2020-05-26|Srgi Holdings, Llc|Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal|
    WO2011075676A2|2009-12-18|2011-06-23|Knowlton Edward W|A skin treatment and drug delivery device|
    US10695546B2|2010-12-17|2020-06-30|Srgi Holdings, Llc|Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal|
    US11109887B2|2013-12-06|2021-09-07|Srgi Holdings, Llc|Pixel array medical systems, devices and methods|
    US10702684B2|2010-12-17|2020-07-07|Srgi Holdings, Llc|Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal|
    US11103275B2|2010-12-17|2021-08-31|Srgi Holdings, Llc|Pixel array medical systems, devices and methods|
    US11229452B2|2013-12-06|2022-01-25|Srgi Holdings, Llc|Pixel array medical systems, devices and methods|
    US10736653B2|2013-12-06|2020-08-11|Srgi Holdings, Llc|Pixel array medical systems, devices and methods|
    US11000310B2|2010-12-17|2021-05-11|Srgi Holdings, Llc|Pixel array medical systems, devices and methods|
    SG11201602636PA|2013-10-02|2016-05-30|Srgi Holdings Llc|Pixel array medical devices and methods|
    ES2827049T3|2013-10-02|2021-05-19|Srgi Holdings Llc|Pixel Set Medical Devices|
    US10543127B2|2013-02-20|2020-01-28|Cytrellis Biosystems, Inc.|Methods and devices for skin tightening|
    PT2991600T|2013-05-03|2018-11-05|Cytrellis Biosystems Inc|Microclosures and related methods for skin treatment|
    BR112016002695A8|2013-08-09|2020-01-28|Cytrellis Biosystems Inc|apparatus for tissue ablation, apparatus for removing portions of ablated tissue, device, kit, skin treatment method and apparatus for skin positioning|
    US10953143B2|2013-12-19|2021-03-23|Cytrellis Biosystems, Inc.|Methods and devices for manipulating subdermal fat|
    CN109152605A|2016-02-25|2019-01-04|通用医疗公司|The device and method of firm skin and other tissues|
    KR20180137500A|2016-03-29|2018-12-27|사이트렐리스 바이오시스템즈, 인크.|DEVICE AND METHOD FOR FACE RESEARCH|
    US10500342B2|2017-08-21|2019-12-10|Miraki Innovation Think Tank Llc|Cold slurry syringe|
    法律状态:
    2018-03-06| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2018-03-13| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2018-03-20| B06I| Publication of requirement cancelled [chapter 6.9 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
    2019-05-07| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|
    2019-07-30| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2020-01-14| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-03-17| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/07/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201261668744P| true| 2012-07-06|2012-07-06|
    US61/668,744|2012-07-06|
    PCT/US2013/049445|WO2014008470A1|2012-07-06|2013-07-05|Method and apparatus for dermatological treatment|
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