cosmetic processes for skin and cosmetic sheet for skin

专利摘要:

公开号:BR112014024011B1
申请号:R112014024011
申请日:2012-04-11
公开日:2018-07-17
发明作者:Shiroya Toshifumi；Laure Bernard Anne；Dumousseaux Christophe
申请人:L'oreal；
IPC主号:

专利说明:

(54) Title: COSMETIC PROCESSES FOR SKIN AND COSMETIC LEAF FOR SKIN (51) Int.CI .: A61K 8/02; A61K 8/67; A61K 8/73; A61K 8/81; A61K 8/85; A61Q 15/00; A61Q 17/00; A61Q
19/00; A61Q 19/02 (73) Holder (s): LOREAL (72) Inventor (s): TOSHIFUMI SHIROYA; ANNE LAURE BERNARD; CHRISTOPHE DUMOUSSEAUX
1/47 “COSMETIC PROCESSES FOR SKIN AND COSMETIC SHEET FOR SKIN”
Field of the Invention [001] The present invention relates to a self-sustaining cosmetic sheet for the skin.
Background of the Invention [002] For applying makeup to the skin, a method of applying a cosmetic sheet, in the form of a layer for the skin, as well as a makeup method using cosmetic compositions, has been proposed.
[003] For example, publication WO 2009/041121 proposed a thin sheet based on polyurethane for cosmetic purposes, which is prepared by applying an adhesive to a layer of polyurethane. This cosmetic sheet is used, for example, to reduce skin wrinkles by tightening the skin with the sheet.
[004] However, since the thickness of the thin polyurethane-based cosmetic sheet described in WO 2009/0401121 is 2 to 20 microns, it is possible that the cosmetic sheet on the skin is perceived.
[005] One of the options for producing the least noticeable cosmetic sheet would be to reduce the thickness of the sheet. However, a reduction in thickness from that cosmetic sheet affects the self-sustaining property and, therefore, the usability is impaired.
[006] Furthermore, when a typical cosmetic sheet such as that described in publication WO 2009/041121 includes an adhesive layer, which is directly attached to the skin, the skin often becomes irritated due to the adhesive layer. In addition, it is possible that the adhesive layer also causes a rash on the skin.
Petition 870180039927, of 05/14/2018, p. 14/23
2/47 [007] One of the options for producing the least irritable cosmetic sheet would be to remove the adhesive layer. However, it is difficult for the cosmetic sheet to adhere to the skin without an adhesive layer. JP-A-2011-136971 describes a cosmetic sheet, without the adhesive layer, but the materials for preparing the cosmetic sheet are quite limited, and biodegradable polymers cannot be used.
[008] Cosmetic sheets for the skin must have superior cosmetic effects, such as the good feeling of the skin touch, good skin pores or concealment of wrinkles and the skin protections against pollution, contaminants and the like.
[009] In addition, it is desirable that the cosmetic sheets for the skin provide additional cosmetic effects, such as reducing the skin's bad smell and whitening the skin.
Brief Description of the Invention [010] An object of the present invention is to provide a cosmetic process using a self-sustaining cosmetic sheet that can provide superior cosmetic effects, such as a good feeling of the touch of the skin, changes in the appearance of the skin, for example, good pore of the skin or concealment of wrinkles and the protection of the skin against pollution, contaminants and the like.
[011] The object above the present invention can be achieved through a cosmetic process to alter the appearance of the skin, altering the sensation of the skin's touch and / or protecting the skin, which comprises the stage of applying a cosmetic sheet to the skin self-supporting which comprises at least one biocompatible and / or biodegradable hydrophobic polymeric layer, in which the self-sustaining cosmetic sheet has a thickness from 10 to 1,000 nm, preferably from 30 to 500 nm and, most preferably, from 50 to 300 nm.
3/47 [012] Another object of the present invention is to provide a cosmetic process using a self-sustaining cosmetic sheet that can provide, in addition to the above properties, the superior cosmetic effects, such as the treatment of skin aging, the absorption of sebum on the skin. skin, control of perspiration on the skin, control of odors on the skin, and the supply of a cosmetic active ingredient through the skin.
[013] The above object of the present invention can be achieved through a cosmetic process for the treatment of skin aging, the absorption of sebum on the skin, the control of perspiration on the skin, the control of odors on the skin and / or the provision of at least one active cosmetic ingredient through the skin, comprising the step of applying a self-sustaining cosmetic sheet comprising at least one biocompatible and / or biodegradable hydrophobic polymeric layer, in which the self-sustaining cosmetic sheet has a thickness from 10 to 1,000 nm, preferably from 30 to 500 nm and, most preferably, from 50 to 300 nm, and the cosmetic sheet comprises at least one cosmetic active ingredient, preferably , selected from antiseptic agents, anti-acne agents, deodorant agents, antiperspirant agents, antibacterial agents, anti-aging agents, bleaching agents or mixtures thereof .
[014] The biocompatible and / or biodegradable hydrophobic polymeric layer may be non-cross-linked, preferably selected from non-cross-linked poly (lactic acid) and its derivatives.
[015] The biocompatible and / or biodegradable hydrophobic polymeric layer may comprise at least one cationic polymer and at least one anionic polymer.
[016] The cationic polymer can have at least one portion
4/47 positively chargeable selected from the group consisting of a quaternary ammonium group, a guanidine group, a biguanide group, an imidazole group, an imino group, a pyridyl group and an amino group.
[017] The cationic polymer can be selected from the group consisting of chitosan, collagen, polyalylamines, polyvinylamines, polydialyldialkylammonium chloride, polyanilines, polyvinylimidazoles, polydimethylaminoethylenemetacrilates, poly-1-methylethine, 2-vinyl-pyyridine polyvinylpyridines, poly (quaternary pyridine), polylysines, polyvinitines, polyarginines, polyhiistidines, polyaminopropyl biguanides, and their salts.
[018] The anionic polymer may have at least one negatively chargeable portion selected from the group consisting of a sulfuric group, a sulfate group, a sulfonic group, a sulfonate group, a phosphoric group, a phosphate group, a group phosphonic, a phosphonate group, a carboxyl group and a carboxylate group.
[019] The anionic polymer can be selected from the group consisting of alginic acid, hyaluronic acid, polyglutamic acid, polylactic acids, polyglycolic acids, polycaprolactones, poly (meth) acrylic acids, polyamic acids, polystyrene sulfonate, poly (sulfate vinyl), dextran sulfate, chondroitin sulfate, polymalleic acids, polyfumaric acids, carboxy methyl cellulose, derivatives of maleic styrene anhydride and their salts.
[020] The cosmetic active ingredient can be selected from anti-sebum agents, anti-acne agents, or ingredients for oily skin.
[021] The cosmetic active ingredient can be a deodorant agent, an antiperspirant agent, or an antibacterial agent. The deodorant agent can be selected from cyclodextrins and their derivatives.
5/47 [022] The cosmetic active ingredient can be an anti-aging agent or a bleaching agent.
[023] The amount of the active cosmetic ingredient (s) can be from 0.01 to 30% by weight, preferably from 0.05 to 20% by weight and more preferably, from 0.1 to 10% by weight, based on the total weight of the cosmetic sheet.
[024] The self-sustaining cosmetic sheet used in the present invention can be attached to a substrate sheet. Preferably, the cosmetic sheet will be peelable from the substrate sheet.
[025] Another object of the present invention is to provide a self-sustaining cosmetic sheet for the skin, which is very thin and not easily perceptible, which can be prepared with a variety of materials such as a biodegradable material, and can adhere well to the skin. skin, without any adhesive layer, and can provide cosmetic effects, such as the treatment of skin aging, the absorption of sebum on the skin, the control of perspiration on the skin, the control of odors on the skin and / or supply of at least one cosmetic active ingredient through the skin. In addition, cosmetic effects can include anti-shine effects, the effects of reducing the bad smell of the skin and the effects of providing active ingredients for skin whitening. The self-sustaining cosmetic sheet can be used for the above cosmetic process.
[026] The object mentioned above of the present invention can be achieved through a self-sustaining cosmetic skin sheet, as described above, wherein the cosmetic sheet comprises at least one cosmetic active ingredient.
Detailed Description of the Invention [027] After diligent research, Depositors have discovered that it is possible to provide a cosmetic process that can provide the effects
6/47 superior cosmetics, such as a good feeling of skin touch, changes in the appearance of the skin, and / or skin protection, through the use of a self-sustaining cosmetic sheet that is very thin, almost transparent, and is not easily noticeable in the skin; that it can be prepared with a variety of materials, such as biocompatible and / or biodegradable material; and a good adhesion on the skin, without any layer of adhesive so that it is less irritable or non-irritable to the skin, and durable for long-term use. The cosmetic sheet can have good air and water permeability and good elasticity due to the very thin thickness of the sheet.
[028] Depositors have also discovered that it is possible to provide a cosmetic process using a self-sustaining cosmetic sheet which can provide, in addition to the above properties, the superior cosmetic effects, such as the treatment of skin aging, the absorption of sebum on the skin, control of perspiration on the skin, control of odors on the skin and / or the supply of a cosmetic active ingredient through the skin.
[029] In addition, Depositors have also discovered that it is possible to provide a self-sustaining cosmetic sheet for the skin that can be used for the above cosmetic process in accordance with the present invention.
[030] Hereinafter, the cosmetic process, according to the present invention, and the self-sustaining cosmetic sheet used for the cosmetic process, according to the present invention, will be explained in detail.
First Realization of the Cosmetic Process [031] An embodiment of the present invention is a cosmetic process to change the appearance of the skin, changing the sensation of the touch of the skin.
7/47 skin, and / or protecting the skin, which comprises the stage of application on the skin, of a self-sustaining cosmetic sheet for the skin, which comprises:
at least one layer of the hydrophobic, biocompatible and / or biodegradable polymer in which the self-sustaining cosmetic sheet has a thickness from 10 to 1,000 nm, preferably from 30 to 500 nm and, most preferably, from 50 to 300 nm.
[032] Hereinafter, the cosmetic sheet used in the first embodiment of the present invention will be explained in detail.
[033] The cosmetic sheet used in the present invention is self-sustaining. The term self-sustaining in the present specification means that the cosmetic sheet used in the present invention can be in the form of a sheet and can be handled as an independent sheet, without the aid of a substrate or support. Therefore, the term self-sustainable can have the same meaning as self-sufficient.
[034] The cosmetic sheet comprises at least one layer of the biocompatible and / or biodegradable polymer. Two or more biocompatible and / or biodegradable polymers can be used in combination. Therefore, a single type of biocompatible and / or biodegradable polymer or a combination of different types of biocompatible and / or biodegradable polymers can be used.
[035] The term biocompatible polymer in the present specification means that the polymer does not exhibit excessive interaction between the polymer and the cells in the living organism, including the skin, and the polymer is not recognized by the living organism as a foreign material.
[036] The term biodegradable polymer in this specification means that the polymer can be degraded or decomposed in a
8/47 living body, due to, for example, the metabolism of the living body itself or the metabolism of microorganisms that may be present in the living body. In addition, the biodegradable polymer can be degraded through hydrolysis.
[037] The term hydrophobic in this specification means that the solubility of the polymer in water (preferably with a volume of 1 liter) at 20 to 40 ° C, preferably from 25 to 40 ° C and more preferably, from 30 to 40 ° C it is less than 10% by weight, preferably less than 5% by weight, more preferably less than 1% by weight and most preferably less than 0.1% by weight, based on the total weight of the polymer. Most preferably, the polymer is not water-soluble.
[038] Since the cosmetic sheet used in the present invention uses a biocompatible and / or biodegradable polymer, it is less irritable or non-irritable to the skin, and does not cause any rash. In addition, in combination with the very thin thickness and the use of a biocompatible and / or biodegradable polymer, the cosmetic sheet used in the present invention can adhere well to the skin.
[039] As examples of biocompatible and / or biodegradable polymers, mention may be made of polyvinyl alcohol and its derivatives; polyethyleneoxides and their derivatives; polyvinylpyrrolidones and their derivatives; polylactic acid; polyamino acids; proteins, such as albumin, caseins, and gelatins; polysaccharides such as glycogen, dextrin, dextran, hydroxypropyl cellulose, agarose, chitin, and pullulan; and carboxyvinyl polymers.
[040] The above polymer may or may not be cross-linked.
[041] Preferably, as the biocompatible and / or biodegradable polymer, a non-cross-linked polymer is used, such as non-cross-linked polylactic acid and its derivatives. Two or more non-crosslinked polymers can be used in combination. Therefore, a single type of
9/47 non-cross-linked polymer or a combination of different types of non-cross-linked polymers can be used.
[042] As derivatives of polylactic acid, mention may be made of the polymer which has the following repetition unit:
wherein R ¹ and R ² independently indicate a hydrogen atom, an alkyl group, an aryl group or a halogen atom, on the condition that R ¹ and R ² do not simultaneously designate a hydrogen atom and a methyl group. The use of polylactic acid as a material for a self-sustaining thin sheet is described in Adv. Mater., 21, 4.388-4.392, 2009, which is incorporated herein as a reference.
[043] Preferably, a cross-linked polymer such as biocompatible and / or biodegradable polymer is also used. Two or more crosslinked polymers can be used in combination. Therefore, a single type of crosslinked polymer or a combination of different types of crosslinked polymers can be used. Preferably, the polymer is cross-linked to enhance its self-sustaining capacity. The use as a material for a self-sustaining thin sheet is described in Pure and Applied Chemistry, 80, 2.259-2.271, 2008, which is incorporated herein by reference.
[044] It is possible to use a combination of at least one non-cross-linked polymer, such as polylactic acid and at least one cross-linked polymer, such as, as the biocompatible and / or biodegradable polymer.
[045] The biocompatible and / or biodegradable polymer, of
Preferably, it can be prepared by comprising at least one cationic polymer and at least one anionic polymer. Therefore, the biocompatible and / or biodegradable polymer preferably can comprise at least one cationic polymer and at least one anionic polymer. Two or more cationic or anionic polymers can be used in combination. Therefore, a single type of cationic or anionic polymer, or a combination of different types of cationic or anionic polymers can be used.
[046] The cationic polymer may have at least one positively chargeable portion selected from the group consisting of a quaternary ammonium group, a guanidine group, a biguanide group, an imidazole group, an imino group, a pyridyl group and a group amino.
[047] The cationic polymer can be selected from the group consisting of chitosan, collagen, polyalylamines, polyvinylamines, polydialyldialkylammonium chloride, polyanilines, polyvinylimidazoles, polydimethylaminoethylenemetacrilates, poly-1-methylethine, 2-vinyl-pyyridines polyvinylpyridines, poly (quaternary pyridine), polylysines, polyvinitines, polyarginines, polyhiistidines, polyaminopropyl biguanides, and their salts. Chitosan is preferred.
[048] The anionic polymer may have at least one negatively chargeable portion selected from the group consisting of a sulfuric group, a sulfate group, a sulfonic group, a sulfonate group, a phosphoric group, a phosphate group, a group phosphonic, a phosphonate group, a carboxyl group and a carboxylate group.
[049] The anionic polymer can be selected from the group consisting of alginic acid, hyaluronic acid, polyglutamic acid, polylactic acids, polyglycolic acids, polycaprolactones, poly (meth) acrylic acids, polyamic acids, polystyrene sulfonate, poly (sulfate vinyl), sulfate
11/47 dextran, chondroitin sulfate, polymalleic acids, polyfumaric acids, carboxy methyl cellulose, derivatives of maleic styrene anhydride and their salts. Alginic acid or its salt is preferably, and sodium alginate is most preferred.
[050] The self-sustaining cosmetic sheet, according to the present invention, has a thickness from 10 to 1,000 nm, preferably from 30 to 500 nm, more preferably, from 50 to 300 nm, from even more preferably, from 70 to 200 nm and, even more preferably, from 80 to 150 nm.
[051] It is possible to prepare this self-sustaining cosmetic sheet with a very thin thickness, for example, alternately laminating a cationic polymer and an anionic polymer or vice versa. Due to the alternative lamination, the positive charge of the cationic polymer and the anionic charge of the anionic polymer are electrostatically attracted to each other, and form a cross-linked structure, which can be advantageous to enhance the self-sustaining property of the cosmetic sheet.
[052] Alternative lamination can be performed, for example, by centrifuging a support such as a SiO2 support, using a solution of the cationic polymer and a solution of the anionic polymer alternately. The preparation of a very thin sheet by coating it by centrifuging a SiO2 support, with a solution of a cationic polymer, such as chitosan and a solution of an anionic polymer, such as sodium alginate, is described in Adv. Mater ., 19, 3.549-3.553, 2007 and Surgery, 148, 48-58, 2010, which are hereby incorporated by reference.
[053] Preferably, the cosmetic sheet according to the present invention comprises a layer of biocompatible and / or biodegradable polymer, which comprises at least one cationic polymer and at least
12/47 less, an anionic polymer, since the polymer prepared through cationic and anionic polymers can be hydrophobic and, therefore, the cosmetic sheet, according to the present invention, can be water resistant, and can present greater durability.
[054] The cosmetic sheet can be applied to the skin for cosmetic purposes, such as for deodorization, skin care, or makeup.
[055] Preferably, the cosmetic sheet according to the present invention comprises a layer of biocompatible and / or biodegradable polymer, which comprises at least one cationic polymer and at least one anionic polymer, since it can capture the acidic and basic foul-smelling molecules through the cationic and anionic groups, respectively, in the polymer, and / or may have antibacterial properties (cationic polymers, such as polysilins that have antibacterial properties).
[056] The first realization of the present invention is a cosmetic process to alter the appearance of the skin, alter the sensation of skin touch, and / or protect the skin.
[057] The above cosmetic process can be performed using the self-sustaining cosmetic sheet, as described above, even if the cosmetic sheet does not comprise any cosmetic active ingredient.
[058] For example, the self-sustaining cosmetic sheet can immediately alter or modify the appearance of the skin, altering the reflection of light on the skin and the like. Therefore, it is possible for the self-sustaining cosmetic sheet to hide skin defects, such as pores or wrinkles. In addition, the self-sustaining cosmetic sheet can immediately alter or modify the feel of the skin's touch, changing the roughness of the
13/47 skin surface and the like. In addition, the self-sustaining cosmetic sheet can immediately protect the skin, covering the skin surface and protecting the skin, as an obstacle, from environmental stresses such as pollution, contaminants and the like.
[059] Therefore, the term cosmetic process for skin protection means that the self-sustaining cosmetic sheet can protect the skin covering the skin surface and protect the skin, as an obstacle, from environmental stresses such as pollution, contaminants and the like.
[060] The cosmetic effects above can be adjusted or controlled by changing the chemical composition, the thickness and / or the surface roughness of the cosmetic sheet.
[061] It is also possible to apply a cosmetic make-up composition, in the cosmetic composition on the cosmetic sheet after being applied to the skin.
[062] Preferably, the self-sustaining cosmetic sheet is used under the conditions in which it is attached to a substrate sheet, since the application of the cosmetic sheet to the skin becomes easier. For example, the composite sheet of the cosmetic sheet and the substrate sheet can be applied to the skin in such a way that the cosmetic sheet is directly in contact with the skin, and the substrate sheet can be removed by peeling the cosmetic sheet or washing with water, if the cosmetic sheet is hydrophobic and the substrate sheet is water-soluble. Therefore, the cosmetic sheet alone can be left on the skin.
Second Realization of the Cosmetic Process and the Cosmetic Sheet
Self-sustaining [063] The second embodiment of the present invention is a
14/47 cosmetic process for the treatment of skin aging, the absorption of sebum on the skin, the control of perspiration on the skin, the control of odors in the skin, and / or the supply of at least one cosmetic active ingredient through the skin, which comprises the step of applying a self-sustaining cosmetic sheet to the skin, which comprises:
at least one layer of the hydrophobic, biocompatible and / or biodegradable polymer in which the self-sustaining cosmetic sheet has a thickness from 10 to 1,000 nm, preferably from 30 to 500 nm and, most preferably, from 50 to 300 nm; and the cosmetic sheet comprises at least one cosmetic active ingredient, preferably selected from anti-sebum agents, anti-acne agents, deodorants, anti-perspirant agents, antibacterial agents, anti-aging agents, bleaching agents or mixtures thereof.
[064] Another aspect of the present invention is, as described above, a self-sustaining cosmetic sheet itself. The self-sustaining cosmetic sheet according to the present invention is intended to be applied to the skin.
[065] In the following, the cosmetic sheet according to the present invention, which is used in this second embodiment of the present invention will be explained in more detail.
[066] The cosmetic sheet used in the second embodiment of the present invention includes at least one active cosmetic ingredient in the cosmetic sheet, preferably in the biocompatible and / or biodegradable hydrophobic polymeric layer used in the cosmetic process,
15/47 according to the first embodiment of the present invention.
[067] There are no limits to the cosmetic active ingredient. Two or more cosmetic active ingredients can be used in combination. Therefore, a single type of cosmetic active ingredient or a combination of different types of cosmetic active ingredients can be used.
[068] According to the present invention, the cosmetic active ingredient can be an anti-sebum agent. The cosmetic sheet according to the present invention, including an anti-sebum agent, can alter the appearance of the skin, reducing the shiny appearance due to sebum. In addition, since the anti-sebum agent is on the leaf, the skin is protected from harmful external factors. Therefore, the cosmetic sheet according to the present invention, including an anti-sebum agent, may be less irritable or non-irritable to the skin.
[069] As examples of the anti-sebum agent, mention can be made of zinc salts, such as zinc lactate, zinc gluconate, zinc pidolate, zinc carboxylate, zinc salicylate and zinc cystate; and magnesium salts, such as magnesium carbonate, magnesium silicate, magnesium nitrate, magnesium sulfate, magnesium acetate, magnesium citrate and magnesium oxide.
[070] It is also possible that the cosmetic active ingredient is selected from sebum regulating agents, such as retinoids, and particularly retinol; sulfur and sulfur-containing derivatives; selenium chloride; vitamin B6 or pyridoxine; the mixture of capriloylglycine, sarcosine and extract of Cinnamomum zeylanicum, in particular, marketed by Seppic under the trade name Sepicontrol A5®; an extract of Laminaria saccharina, in particular, marketed by Secma under the trade name Phlorogine®; an extract
16/47 from Spiraea ulmaria, in particular, marketed by Silab under the trade name Sebonormine®; plant extracts of the species Arnica montana, Cinchona succirubra, Eugenia caryophyllata, Humulus lupulus, Hypericum perforatum, Mentha piperita, Rosmarinus officinalis, Salvia officinalis and Thymus vulgaris, all marketed, for example, by Maruzen; an extract from Serenoa repens, in particular, marketed by Euromed; plant extracts of the genus Silybum; vegetable extracts containing sapogenins, and especially extracts rich in Dioscoreaceae diosgenin; and extracts of Eugenia caryophyllata that contain the eugenol and eugenyl glycoside.
[071] According to the present invention, the cosmetic active ingredient can be an anti-acne agent.
[072] According to the present invention, the cosmetic active ingredient can be a deodorant agent, an antiperspirant agent, or an antibacterial agent.
[073] As examples of the deodorant, mention can be made of chelating agents, such as EDTA and DPTA; enzyme inhibitors, involving the formation of foul-smelling compounds, such as arylsulfatase, 5-lipoxygenase, aminocylase, and beta-glucuronidase inhibitors; zeolites; cyclodextrins; and metal oxide silicates.
[074] Preferably, the deodorant is selected from cyclodextrins and their derivatives. Any type of cyclodextrins and their derivatives can be used. The cyclodextrin that can be used can be selected from, for example, the Formula oligosaccharides:
17/47
where x is selected from (4) (corresponding to acyclodextrin), (5) (corresponding to β-cyclodextrin) and (6) (corresponding to ycyclodextrin). In one embodiment, cyclodextrin can be selected from β-cyclodextrin and γ-cyclodextrin, for example, β-cyclodextrin. A β-cyclodextrin marketed by the company WACKER under the name Cavamax W7 PHARMA and a γ-cyclodextrin marketed by the company WACKER under the name Cavamax W8, for example, can be used. In another embodiment, cyclodextrin derivatives can be selected, for example, from methylcyclodextrins such as methyl-βcyclodextrin marketed by the company WACKER under the name CAVASOL W7.
[075] As examples of the antiperspirant agent, mention can be made of aluminum salts, zirconium salts and zinc salts, as mentioned above. Antiperspirant aluminum salts are preferably. As used herein, the term antiperspirant aluminum salt means any salt or any aluminum complex that has the effect of reducing or limiting the flow of sweat. The aluminum salt according to the present invention can, for example, be selected from aluminum halohydrates; aluminum and zirconium halohydrates; and zirconium hydroxychloride and aluminum hydroxychloride complexes, with an amino acid, such as those described in US patent 3,792,068, which are commonly known as ZAG complexes. Among the aluminum salts that can be mentioned, for example, are aluminum hydrochloride in activated or inactivated form,
18/47 aluminum chlorohydrex, aluminum chlorohydrex polyethylene glycol complex, aluminum chlorohydrex propylene glycol complex, aluminum dichlorohydrate, aluminum dichlorohydrex polyethylene glycol complex, aluminum dichlorohydrex propylene glycol complex, aluminum sesichlorohydrate aluminum sesquichlorohydrex complex, polyethylene glycol aluminum sesquichlorohydrex complex, and aluminum sulfate buffered with sodium and aluminum lactate. Among the double salts of aluminum and zirconium that can be mentioned, for example, are zirconium and aluminum octachlorhydrate, zirconium and aluminum pentachlor, aluminum and zirconium tetrachlorohydrate, zirconium and aluminum trichlorohydrate. An example of a double aluminum and zirconium salt is the product marketed by the company Reheis under the name AZP-908-SUF. The complexes of zirconium and hydroxychloride of aluminum hydroxychloride, with an amino acid, in general, are known under the name of ZAG (when the amino acid is glycine). Among these products, mention can be made of the aluminum and zirconium octachlorohidrex glycine complexes, zirconium and aluminum pentachlorohidrex glycine, aluminum and zirconium tetrachlorohidrex glycine, and aluminum and zirconium trichlorohydrex glycine.
[076] As examples of the antibacterial agent, mention should be made of 2,4,4'-trichloro-2'-hydroxydiphenyl ether (or triclosan), 3,4,4'trichlorocarbanilide, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, hexamidine isethionate , metronidazole and its salts, miconazole and its salts, itraconazole, terconazole, econazole, ketoconazole, saperconazole, fluconazole, clotrimazole, butoconazole, oxyzazole, sulfaconazole, sulconazole, terbinafine, cyclopoxyoxy, and amoxicol, cyclopoxide benzoyl peroxide, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, phytic acid, N-acetyl-L-cysteine, lipoic acid, azelaic acid and its salts, arachidonic acid, resorcinol, octopirox, octoxiglycerol, octanolglycine,
19/47 caprylylglycol, 10-hydroxy-2-decanoic acid, dichlorophenyl dioxolane imidazole and its derivatives described in publication WO 9318743, copper pidolate, salicylic acid, iodopropynyl butylcarbamate, farnesol, phytosphingosinfs and mixtures thereof. In addition, metal salts can be used, which can supply metal ions, such as silver ions.
[077] According to the present invention, the cosmetic active ingredient can be an anti-aging agent or a bleaching agent.
[078] The active anti-aging agent can be any active agent capable of treating or preventing any signs of skin aging.
[079] As examples of the anti-aging agent, mention may be made of moisturizers, free radical scavengers, keratolytic agents, vitamins, anti-elastase and anti-collagenase agents, protides, fatty acid derivatives, steroids, trace elements, bleaching agents, algae extracts and of plankton, sunscreens, enzymes and coenzymes, flavonoids and ceramides and their mixtures.
[080] (I). Moisturizers include sodium lactate; polyols, and in particular, glycerol, sorbitol and polyethylene glycols; mannitol; amino acids; hyaluronic acid; lanolin; urea and mixtures containing urea, such as NMF (Natural Hydration Factor); petroleum jelly; and their mixtures.
[081] (II). Useful free radical scavengers include phosphonic acid derivatives, such as ethylene diaminetetra (methylene phosphonic acid), hexamethylenediaminatetra (methylene phosphonic acid), diethylene triamminenta (methylene phosphonic acid), and their salts and in particular their sodium salts, such as sodium salts ethylenediamine tetra (methylenephosphonic acid); ethylenediaminetetraacetic acid and its salts such as the sodium salt; guanosine; superoxydismutase; tocopherol (vitamin E) and its
20/47 derivatives (acetate); ethoxyquin; lactoferrin; lactoperoxidase and nitroxide derivatives; dismutase superoxide; glutathione peroxidase; vegetable extracts with free radical scavenging activity, such as the aqueous extract of wheat germ marketed by the company Silab under the reference Detoxiline; and their mixtures.
[082] (III). Useful keratolytic agents include α-hydroxy acids, especially those derived from fruits, for example, glycolic acid, lactic acid, malic acid, citric acid, tartaric acid and mandelic acid and their derivatives and mixtures thereof; β-hydroxy acids, for example, salicylic acid and its derivatives, such as 5-n-octanoylsalicylic acid or 5-n-dodecanoysalicylic acid; α-keto acids, for example, ascorbic acid or vitamin C and its derivatives, such as their salts, for example, sodium ascorbate, magnesium phosphate ascorbyl or sodium phosphate ascorbyl; their esters, for example ascorbyl acetate, ascorbyl palmitate and propionate, or their sugars, for example, to glycosylated ascorbic acid, and mixtures thereof; β-keto acids; retinoids, for example, retinol (vitamin A) and its esters, retinal, retinoic acid and its derivatives, and also the retinoids described in patents FR-A-2,570,377, EP-A199,636, EP-A-325- 540 and EP -A-402,072; and their mixtures.
[083] (IV). The vitamins, in addition to vitamins A, E and C above, include vitamin B3- (or vitamin PP or niacinamide), vitamin B5 (or panthenol), vitamin D, vitamin F, derivatives, analogs and precursors of these vitamins and also those vitamins A, E and C, for example, lycopenes or carotenes that are precursors of vitamin A, and mixtures thereof.
[084] Vitamin B3, also known as vitamin PP, is a compound of Formula:
21/47
where R can be -CONH ₂ - ₍ niacinamide), -COOH (nicotinic acid or niacin), CH ₂ OH (nicotinyl alcohol), -CO-NH-CH ₂ -COON (nicotinuric acid) or -CO-NH-OH (nicotinyl hydroxamic acid). Derivatives of vitamin B3 include esters of nicotinic acid, such as tocopherol nicotinate; amides derived from niacinamide by substituting the hydrogen groups of CONH ₂ ; reaction products with carboxylic acids and amino acids; esters of nicotinyl alcohol and carboxylic acids, such as acetic acid, salicylic acid, glycolic acid or palmitic acid. The following derivatives can also be mentioned: 2-chloronicotinamide, 6-methylnicotinamide,
6-aminonicotinamide, N-methylnicotinamide, Ν, Ν-dimethylnicotinamide, N (hydroxymethyl) nicotinamide, quninolinic acid imide, nicotinanilide, Nbenzylnicotinamide, N-ethylnicotinamide, nifenazone, acid, isotonic, nicotinamide, 2-amino nicomol and niaprazine. Other derivatives of vitamin B3, which can also be mentioned include mineral salts, such as chlorides, bromides, iodides and carbonates, and their organic salts, such as salts obtained through reaction with carboxylic acids, such as acetate , salicylate, glycolate, lactate, malate, citrate, mandelate, tartrate, and the like.
[085] As vitamin B5, it is also possible to use panthenol or panthenyl alcohol or 2,4-dihydroxy-N (3-hydroxypropyl) -3,3-dimethylbutanamide, in its various forms: D-panthenol, DL-panthenol, and its derivatives and analogues, such as calcium pantothenate, pantethine, pantothin, ethyl panthenyl ether, pangamic acid, pyridoxine and pantoillactose and the natural compounds that contain them, such as royal jelly.
22/47 [086] As vitamin D, mention may be made of vitamin D3 1a, 25-dihydroxy and its analogs, as well as vitamin D analogs, such as those described in publication WO A-00/26167, such as, for example:
3-hydroxymethyl-5- {2- [3- (5-hydroxy-5- or 6-methylhexyl) -phenyl] -vinyl} phenol, [3- (5-hydroxy-1,5-dimethylhexyl) phenoxymethyl] -5-hydroxymethylphenol,
6- [3- (3,4-bis-hydroxymethyl-benzyloxy) -phenyl] -2-methyl-hepta-3,5diene-2-ol,
6- [3- (3,4-bis-hydroxymethyl-benzyloxy) -phenyl] -2-methyl-hexan-2-ol,
6- [3- (3,4-bis-hydroxymethyl-phenoxymethyl) -phenyl] -2-methyl-heptan-2ol,
7- [3- (3,4-bis-hydroxymethyl-phenoxymethyl) -phenyl] -3-ethyl-octan-3-ol,
5- {2- [4 (5-hydroxy-5-methylhexyl) -phenyl] -vinyl or ethyl} -benzene-1,3diol,
5- {2- [3- or 4- (6-hydroxy-6-methyl-heptyl) -phenyl] -vinyl} -benzene-1,3diol,
5- {2- [3- or 4- (6-hydroxy-6-methyl-heptyl) -phenyl] -ethyl-benzene-1,3diol,
2-hydroxymethyl-4- {2- [3- or 4- (5-hydroxy-5-methylhexyl) -phenyl] -vinylphenol,
2-hydroxymethyl-4- {2- [3- or 4- (6-hydroxy-6-methyl-heptyl) -phenyl] -vinyl} phenol,
2-hydroxymethyl-4- {2- [3- or 4- (5-hydroxy-5-methyl-heptyl) -phenyl] -ethyl} phenol,
2-hydroxymethyl-4- {2- [3- or 4- (6-hydroxy-6-methyl-heptyl) -phenyl] -ethyl} phenol,
2-hydroxymethyl-5- (2- [4 (5-hydroxy-5-methylhexyl) -phenyl] -vinyl-phenol,
23/47
6- [3- (3,4-bis-hydroxymethyl-benzyloxy) -phenyl12-methyl-heptan-2ol,
4- [3- (5-hydroxy-1,5-dimethyl-hexyl) phenoxymethyl] 2-hydroxymethylphenol,
6- [3 or 4- [2- (3,4-bis-hydroxymethyl-phenyl) vinyl] phenyl} -2-methylhexan-2-ol,
7- {4- [2- (3,4-bis-hydroxymethyl-phenyl) vinyl] phenyl} -2-methyl-heptan-2ol,
5- {2- [3- (6-hydroxy-6-methyl-heptyl) -phenyl] -1-methyl-benzene-1,3-diol, 5- {2- [3- (5-hydroxy-5- methylhexyl) -phenyl] -vinyl} -benzene-1,3-diol,
5- [3- (6-hydroxy-6-methyl-heptyl) phenoxymethyl] benzene-1,3-diol, 5- {2- [3- (7-hydroxy-7-methyl-oct-1-enyl) - phenyl] -vinyl} -benzene-1,3diol,
5- {2- [3- (7-hydroxy-7-methyl-octyl) -phenyl] -vinillbenzene-1,3-diol, {2- [3- (6-hydroxy-6-methyl-heptyl) -phenyl ] -vinyl) benzene-1,2-diol, 3- {2- [3- (6-hydroxy-6-methyl-heptyl) -phenyl] -vinyl} -phenol,
6- {3 [2- (3,5-bis-hydroxymethyl-phenyl) vinyl] phenyl} -2-methyl-hexan-2-ol, 3- {2- [3- (7-hydroxy-7-methyl- octyl) -phenyl] -vinyl} -phenol,
7- {3 [2- (3,5-bis-hydroxymethyl-phenyl) vinyl] phenyl-2-methyl-heptan-2-ol,
7- {3 [2- (3,4-bis-hydroxymethyl-phenyl) vinyl] phenyl} -2-methyl-heptan-2ol,
7- {3 [2- (4-hydroxymethyl-phenyl) vinyl] phenyl} 2-methyl-heptan-2-ol, {2- [3- (7-hydroxy-7-methyl-oct-1-enyl) - phenyl] -vinyl} -benzene-1,2diol,
7- [3- (3,4-bis-hydroxymethyl-phenylethynyl) -phenyl] 2-methyl-heptan-2-ol, 5- {2- [3- (6-hydroxy-6-methyl-hept-1- enyl) -phenyl] -vinyl} -benzene-1,3diol,
5- {2- [3- (7-ethyl-7-hydroxy-non-1-enyl) -phenyl] -vinyl) benzene-1,324 / 47 diol,
5- {2- [3- (7-hydroxy-1-methoxy-1,7-dimethyl-octyl) -phenyl] -vinillbenzene-1,3-diol,
5- {2- [3- (6-hydroxy-1-methoxy-1,6-dimethyl-heptyl) -phenyl] -vinyl} benzene-1,3-diol,
5- {2- [3- (5-hydroxy-pentyl) -phenyl] -vinyl benzene1,3-diol, 5- {2- [3- (5-hydroxy-6-methyl-heptyl) -phenyl] -vinyl } -benzene-1,3-diol, 5- {2- [3- (6-hydroxy-7-methyl-octyl) -phenyl] -vinyl) benzene-1,3-diol, 5- {2- [3 - (5-hydroxy-6-methyl-hept-1-enyl) -phenyl] -vinyl} -benzene-1,3diol,
5- {2- [3- (6-hydroxy-7-methyl-oct-1-enyl) -phenyl] -vinyl} -benzene-1,3diol,
5- {2- [3- (1,6-dihydroxy-1,6-dimethyl-heptyl) -phenyl] -vinyl} -benzene-1,3diol, and
5- (2- [3- (6-hydroxy-1,6-dimethyl-maintained-1-enyl) -phenyl] -vinyl} benzene-1,3-diol.
[087] Vitamin F is a mixture of essential fatty acids, that is, unsaturated acids that contain at least one double bond, such as linoleic acid or 9,12-octadecadienic acid, and its stereoisomers, linolenic acid in α form (9,12,15-octadecatrienoic acid) or γ form 6,9,12-octadecatrienoic acid) and its stereoisomers, arachidonic acid or 5,8,11,14-eicosatetraenoic acid and its stereoisomers. Vitamin F or its analogs, such as mixtures of unsaturated acids that contain at least a double bond, and especially mixtures of linoleic acid, linolenic acid and arachidonic acid, or the compounds containing them, and especially oils of vegetable origin, which contain them, such as jojoba oil, can be used in the cosmetic sheet of the present invention.
25/47 [088] (V). Useful antielastase agents include peptide derivatives and peptides, especially from legume seeds, such as those sold by Laboratoires Seriobiologiques de Nancy, under the reference Parelastyl; the N-acylamino amide derivatives described in patent application FR-A-2180033, such as, for example, ethyl {2- [acetyl (3 trifluoromethylphenyl) amino] -3-methylbutyrylamino} acetate and acetic acid 2 { [acetyl- (3-trifluoromethylphenyl) amino] -3-methylbutyrylaminol, and mixtures thereof. Anticollagenase agents that may be mentioned include metalloprotease inhibitors, such as ethylenediamine acid (EDTA) and cysteine, and mixtures thereof.
[089] (VI). Useful protides include proteins (wheat or soy protein), their hydrolysates, for example, those sold by the company Silab under the reference Tensine, and their mixtures.
[090] (VII). Useful phospholipid fatty acid derivatives include polyunsaturated fatty acids, including essential fatty acids, octopus phospholipids, and mixtures thereof.
[091] (VIII). Useful steroids include DHEA or dehydroepianderesterone, its biological precursors, its metabolites, and mixtures. The term biological precursors of DHEA, especially means Δδ-pregnenolone, 17a-hydroxypregnenolone and 17ahidroxipregnenolone sulfate. The term DHEA derivatives means its metabolic derivatives and its chemical derivatives. Metabolic derivatives that may be especially mentioned include Δ5-androstene-3,17-diol and, especially, 5-androstene-33, 17.beta -.- Diol, Δ4-androstene-3,17-dione, 7- DHEA hydroxy (7a-hydroxy DHEA or DHEA 7p-hydroxy) and 7-keto-DHEA, which is itself a 7EA-hydroxy DHEA metabolite. A preferred group is dehydroepiandrosterone, 5-pregnenolone, 17-hydroxypregnenolone, 17-hydroxypregnenolone sulfate, 5-androstene-3,17-diol, 4-androstene-3,17-dione, 726/47 DHEA hydroxy, 7- DHEA hydroxy, keto-DHEA, and mixtures thereof.
[092] (IX). Useful trace elements include copper, zinc, selenium, iron, magnesium and manganese, and mixtures thereof.
[093] (X). Useful bleaching agents include any compound for the treatment or prevention of age marks, that is, any depigmentation compound that acts directly on the vitality of the melanocytes of the epidermis in which melanogenesis occurs and / or that interferes with one of the steps melanin biosynthesis, through the inhibition of one of the enzymes involved in melanogenesis or intercalated, becoming as a structural analog of one of the chemical compounds in the melanin synthesis chain, the chain in which, therefore, they can be blocked and cause depigmentation. Active bleaching agents that can be mentioned, for example, include cojic acid and its derivatives, hydroquinone and its derivatives, such as arbutin and its esters; ellagic acid and its derivatives; plant extracts and, in particular, liquorice, blackberry or scutellaria extracts; glutathione and its precursors; cysteine and its precursors; aminophenol-derived compounds, which are described in publication WO A-99/10318, such as, especially, N-ethyloxycarbonyl-4-aminophenol, N-ethyloxycarbonyl-Oethyloxycarbonyl-4-aminophenol, N-cholesteryloxycarbonyl-4-aminophenol and Netylaminocarbonyl-4-aminophenol; and mixtures of these compounds.
[094] (XI). Useful seaweed extracts include red or brown seaweed extracts and, for example, the brown seaweed extract of the Laminaria family, for example, extracts of the species of Laminaria digitata, and more particularly the product marketed by the company CODIF under the name Phycosaccharides, which is a concentrated solution of an oligosaccharide obtained through controlled enzymatic depolymerization of the polysaccharides of the membrane of a brown alga. It consists of a
27/47 sequence of two uric acids: manuronic acid and guluronic acid.
[095] (XII). Useful plankton extracts include plankton in aqueous dispersion (CTFA name: Vitreoscilla Ferment) marketed under the name Mexoryl HAS by the company Chimex.
[096] (XIII). Useful enzymes that can be used include any animal enzyme, microbiological (bacteria, fungi or viruses) or of synthetic origin (obtained through chemical or biotechnological synthesis), in pure crystalline form or in a form diluted in an inert diluent. Examples that can be mentioned are, among proteases, lipases, phospholipases, cellulases, peroxidases and especially lactoperoxidases, catalases and dismutase superoxide, or among plant extracts that contain the enzymes mentioned above, and mixtures thereof. They can be selected, for example, from the product marketed under the trade name Subtilisine SP 554 by the company Novo Nordisk and the product marketed under the trade name Lysoveg LS by the company Laboratoires Serobiologiques de Nancy. Coenzymes that can be used especially include ubiquinone or coenzyme Q 10, which belongs to the alkylene chain benzoquinone family, coenzyme R, which is biotin (vitamin H or), and mixtures thereof.
[097] (XIV). Useful flavonoids that can be mentioned, for example, include isoflavones, which are a subclass of flavonoids, formed from a 3-phenylchroman skeleton that can comprise different substituents and different levels of oxidation. The term isoflavonoid combines several classes of compounds, among which mention may be made of isoflavones, isoflavanones, rotenone, pterocarpanes, isoflavans, isoflavan-3-enos, 3-arylcoumarines, 3-aryl-4hydroxycoumarins, coumestanes, coumaronochromones, α-2 -methyloxybenzoins and arylbenzofurans, and mixtures thereof. In this regard, reference should be made to
28/47 advantageous, for a complete review of isoflavonoids, their methods of analysis and their sources, to chapter 5 isoflavonoids, written by PM Dewick in The Flavonoids, edited by Harbone, pp. 125-157 (1988).
[098] Isoflavones can be of natural or synthetic origin. The term natural origin means an isoflavonoid in pure or dissolved form at different concentrations, obtained through different processes of extracting an element, in general, a vegetable of natural origin. The term synthetic origin means an isoflavonoid in pure or dissolved form at different concentrations, obtained by chemical synthesis. Isoflavonoids of natural origin are preferably used. Among these, mention can be made of: daidzine, genistin, daidzein, formononetine, cuneatin, genistein, isoprunetin and prunetin, cajanine, orobol, pratensein, Santal, junipegenin A, glycitein, afrormosin, retusin, tectorigenin, irisolidone and jamaisone and jamaine also to its analogues and metabolites.
[099] (XV). Useful ceramides that can be used include any type of ceramide of natural or synthetic origin, for example, type II, type III, type IV, type V or type VI, and mixtures thereof. Examples of ceramides that can be mentioned include Noleoildiidrosfingosina, N-estearoilfitosfingosina, N-ahidroxibehenoildiidrosfingosina, hydrosphingosina-N-a hydroxipalmitoildi-, Nlinoleoldiidrosfingosina, N-palmitoildiidrosiingosine-eina, Nina. Mention may also be made of the product consisting of a mixture of glucoceramides, marketed under the trade name Glycocer by the company Waitaki Internacional Biosciences; the compounds described in EP-A-0.227.994 and WO-A94 / 07844, such as, for example, Questamide H (bis (N-hydroxyethylNcetyl) malonamide) marketed by Quest, N- (2hydroxyethyl) cetyl acid -N- (3-ketyloxy-2-hydroxypropyl) amide; N-docosanoyl-N-methyl-D29 / 47 glucamine, described in patent application WO-A-92/05764. Mixtures of these ceramides can also be used.
[0100] As examples of the bleaching agent, mention may be made of ascorbic acid or its derivatives, cojic acid or its derivatives, tranexamic acid or its derivatives, resorcinol or its derivatives, alkoxysalicylic acid or its salts, adenosine phosphate or its salts , hydroquinone or its glycosides or derivatives, glutathione, 4- (4hydroxyphenyl) -2-butanol, magnolignan (5, '-biphenyl-dipropyl-2,2-diol), placenta extracts, chamomile recutite, and the like .
[0101] Ascorbic acid has either a D configuration or an L configuration, and the L configuration is preferably used. Ascorbic acid is also referred to as vitamin C, and has effects of inhibiting melanin production, due to the strong reducing effects of ascorbic acid. The ascorbic acid derivatives may be the ascorbic acid salts, and the ascorbic acid salts are preferably selected from sodium ascorbate, ascorbyl magnesium phosphate, and sodium ascorbyl phosphate. The ascorbic acid derivatives can be the ascorbic acid glycosides or ascorbic acid esters. As an example of ascorbic acid glycosides, mention may be made, for example, of ascorbyl glucoside. As examples of ascorbic acid esters, mention may be made, for example, of silyl ascorbate, tocopheryl ascorbate, alkyl and ascorbate. Like alkyl ascorbate, methyl ascorbate or ethyl ascorbate is preferably used. In particular, preferably, it is ascorbyl glucoside. Ascorbic acid or its derivatives can be used alone or in combination with two or more types thereof.
[0102] As detailed examples of ascorbic acid derivatives, mention may be made, for example, of 5,6-di-Odimethylsilyl ascorbate, which is commercially available as PRO-AA from Exsymol
30/47
SAM; dl-alpha-tocopheryl-2-1-ascorbyl phosphate, which is commercially available as SEPIVITAL EPC from Senju Pharmaceutical Co., Ltd .; ascorbyl sodium phosphate, which is commercially available as Stay-C 50 from Roche; ascorbyl glucoside, which is commercially available from Hayashibara Biochemical Labs. Inc .; ascorbic acid 3-O-ethyl; and the like.
[0103] Ascorbic acid or its derivative is preferably used in combination with a copolymer of styrene and maleic anhydride. In particular, at least a part of the maleic anhydride unit of the aforementioned copolymer is preferably hydrolyzed. The hydrolyzed maleic anhydride unit mentioned above can be in the form of an alkaline salt such as a sodium salt, a potassium salt, a lithium salt, or the like. The maleic anhydride unit mentioned above preferably occupies 0.4 to 0.9 mol per one mole of the entire copolymer, and the ratio between the maleic anhydride unit and the styrene unit is preferably 50 : 50. In particular, preferably, the ratio of the maleic anhydride unit and the styrene unit is preferably 50:50, and the ammonium salt or sodium salt is used. By using ascorbic acid or its derivative, in combination with the copolymer mentioned above, the stability of ascorbic acid or its derivative is improved. Like the copolymer mentioned above, for example, a copolymer of styrene and maleic anhydride (50/50) in the form of an ammonium salt in a concentration of 30% in water, which is commercially available as product number SMA 1,000 H (trademark) ), Atofina Chemicals Inc .; or a copolymer of styrene and maleic anhydride (50/50) in the form of a sodium salt in a concentration of 40% in water, which is commercially available as product number SMA 1,000 H Na (trademark) from Atofina Chemicals Inc., can be used. The copolymer mentioned above is used in a concentration that ranges from 0.1 to 20% by weight and preferably ranges from 0.1 to 10% by weight.
31/47 weight, in relation to the total weight of the bleaching agent for topical application.
[0104] As an example of cojic acid derivatives, mention may be made, for example, of cojic acid glucoside.
[0105] As examples of tranexamic acid derivatives, mention can be made of dimers of tranexamic acid (such as trans-4- carboxylic acid hydrochloric acid (trans-aminomethylcycloexanecarbonyl aminomethylcyclohexane), esters of tranexamic acid and hydroquinone (such as 4'-hydroxyphenyl trans-4-aminomethylcyclohexane carboxylate), esters of tranexamic acid and gentisic acid (such as 2- (trans-4aminomethylcyclohexanecarbonyloxy) -5-hydroxy-benzoic acid and its salts), tranexamic amides (such as a trans-4aminomethylcyclohexane carboxylic acid methylamide and its salts, trans-4- (pmethoxybenzoyl) aminomethylcyclohexane carboxylic acid and its salts, and trans-4guanidinomethylcyclohexane carboxylic acid and its salts), and the like.
[0106] As examples of resorcinol derivatives, mention may be made, for example, of 4-n-butylresorcinol (Rucinol) and the like.
[0107] An alkoxysalicylic acid is a compound in which any of the hydrogen atoms in position 3, position 4, or position 5 of salicylic acid is replaced by an alkoxy group. The alkoxy group mentioned above is preferably any of a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group and, most preferably, is a methoxy group or an ethoxy group . As examples of the compound, mention may be made, for example, of 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid acid, 5-ethoxysalicylic acid, 5-propoxysalicylic acid, and the like. Salts of alkoxysalicylic acids are not particularly
32/47 limited. As examples of these, mention may be made, for example, of alkali metal salts or alkaline earth metal salts, such as sodium salts, potassium salts, calcium salts, and the like, ammonium salts, amino acid salts , and the like. A potassium salt of 4methoxysalicylic acid is preferably.
[0108] As examples of adenosine phosphate or its salts, mention may be made, for example, of adenosine phosphate, and the like.
[0109] As examples of hydroquinone glycosides, mention may be made, for example, of hexoses glycosides, such as hydroquinone alpha-D-glucose, hydroquinone-beta-D-glucose, hydroquinone alpha-Glucose, hydroquinone beta-L -glucose, hydroquinone alpha-D-galactose, hydroquinone-beta-D-galactose, hydroquinone alpha-L-galactose, hydroquinone beta-L-galactose, and the like; pentose glycosides such as hydroquinone alpha-D-ribose, hydroquinone beta-D-ribose, hydroquinone alpha-Lribose, hydroquinone beta-L-ribose, hydroquinone alpha-D-arabinose, hydroquinone beta-D-arabinose, hydroquinone L- alpha-arabinose, hydroquinone beta-L-arabinose, and the like; sugar amine glycosides such as hydroquinone alpha-D-glucosamine, hydroquinone beta-D-glucosamine, hydroquinone alpha-L-glucosamine, hydroquinone beta-L-glucosamine, hydroquinone alpha-D-galactosamine, hydroquinone beta-D-galactosamine , hydroquinone alpha-L-galactosamine, hydroquinone beta-L-galactosamine, and the like; urocanic acid glycosides, such as hydroquinone, alpha-D-glucuronic, hydroquinone beta-D-glucuronic acid, hydroquinone alpha-L-glucuronic acid, hydroquinone beta-L-glucuronic acid, hydroquinone alpha-Dgalacturonic acid, hydroquinone beta-D galacturonic acid, a hydroquinone-alpha-L-galacturonic acid, hydroquinone-beta-L-galacturonic acid, and the like; and the like. Among these compounds, hydroquinone-beta-D-glucose (hereinafter
33/47 onwards, referred to as arbutin) is preferably. As examples of hydroquinone derivatives or their glycosides, mention may be made, for example, of hydroquinone salts or their glycosides. In particular, as examples of arbutin derivatives, mention may be made, for example, of 6O-caffeoilarbutin, and the like.
[0110] As the active bleaching ingredients, in particular, L-ascorbic acid or its derivatives, cojic acid or its derivatives, tranexamic acid or its derivatives, arbutin and its derivatives, and Rucinol are preferably and, the derivatives of ascorbic acid such as L-ascorbic acid 3-O-ethyl and glycoside L-ascorbic acid are most preferred.
[0111] The self-sustaining cosmetic sheet according to the present invention can comprise the cosmetic active ingredient (s) in an amount from 0.01 to 30% by weight, preferably , from 0.05 to 20% by weight and, more preferably, from 0.1 to 10% by weight, in relation to the total weight of the cosmetic sheet.
[0112] The cosmetic sheet according to the present invention may comprise, in addition to the components mentioned above, the components normally employed in cosmetics, specifically, such as acids, bases, salts, pigments, powders, surfactants, oils , organic solvents, silicones, silicone derivatives, natural extracts derived from animals or plants, waxes, and the like, within a range that does not impair the effects of the present invention.
[0113] The self-sustaining cosmetic sheet, according to the present invention, can be attached to a substrate sheet. The materials for the substrate are not limited. Two or more materials can be used in combination. Therefore, a single type of material or a combination of different types of materials can be used. In any
34/47 preferably, the substrate sheet is flexible or elastic.
[0114] Most preferably, the substrate is water-soluble, since it is possible to remove the cosmetic sheet, according to the present invention, by washing the substrate with water, if the cosmetic sheet is hydrophobic. In fact, as mentioned above, a combination of a cationic polymer and an anionic polymer can form a hydrophobic sheet. Accordingly, a combination of a water-soluble substrate sheet and a cosmetic sheet, according to the present invention, comprises at least one biocompatible and / or biodegradable hydrophobic polymer, which comprises at least one cationic polymer and at least , an anionic polymer is preferably. As examples of water-soluble materials, mention may be made of poly (meth) acrylic acids, polyethylene glycols, polyacrylamides, polyvinyl alcohol (PVA), starch, celluloseacetates, and the like. PVA is preferred.
[0115] The substrate sheet may have a thickness greater than that of the cosmetic sheet, according to the present invention, to facilitate the manipulation of the cosmetic sheet attached to the substrate sheet. The thickness of the substrate sheet is not limited, but it can be from 1 pm to 5 mm, preferably from 10 pm to 1 mm and, most preferably, from 50 to 500 pm.
[0116] Most preferably, the cosmetic sheet is detachable from the substrate sheet. The manner of highlighting is not limited. Accordingly, the cosmetic sheet can be peeled from the substrate sheet, or detached by dissolving the substrate sheet in a solvent such as water.
[0117] The self-sustaining cosmetic sheet, according to the present invention, is used for cosmetic treatments for the skin, in particular the face. The self-sustaining cosmetic sheet, according to the
35/47 present invention, can be in any shape or form. For example, it can be used as a face mask sheet, or a layer on part of the face, such as the face, nose, and around the eyes.
[0118] The second embodiment, according to the present invention, is a cosmetic process for the treatment of skin aging, the absorption of sebum on the skin, the control of perspiration on the skin, the control of odors in the skin, and / or the supply of at least one cosmetic active ingredient through the skin, comprising the step of applying the self-sustaining cosmetic sheet to the skin, which is the same as that used in the first embodiment, according to the present invention, provided that comprise at least one cosmetic active ingredient, as described above.
[0119] In particular, the present invention can provide an active ingredient or cosmetic ingredients to the skin or through the skin. A high concentration of cosmetic active ingredient (s) can be incorporated into the cosmetic sheet, according to the present invention, and can be maintained inside the sheet, since the sheet is self-sustaining. Therefore, by applying the cosmetic sheet, according to the present invention, to the target area of the skin, the active cosmetic ingredient (s) can be supplied to or through the skin for a long time.
[0120] Since the cosmetic sheet, according to the present invention, has a very thin thickness of about 10 to 1,000 nm, preferably from 30 to 500 nm, more preferably, from 50 to 300 nm, even more preferably, from 70 to 200 nm and even more preferably, from 80 to 150 nm, the active ingredient (s) in the sheet can easily be diffuse into the skin. As a result, effective penetration of the active ingredient (s) into the skin can be accomplished.
36/47 [0121] The cosmetic effects above can be adjusted or controlled by changing the chemical composition, thickness and / or roughness of the cosmetic sheet surface, in accordance with the present invention, as well as by changing the type and / or the amount of an active cosmetic ingredient.
[0122] It is also possible to apply a cosmetic makeup composition to the cosmetic sheet, according to the present invention, after being applied to the skin.
[0123] Preferably, the self-sustaining cosmetic sheet, according to the present invention, is used under the conditions in which it is attached to a substrate sheet, since the application of the cosmetic sheet to the skin becomes easier. For example, the composite sheet of the cosmetic sheet, according to the present invention, and the substrate sheet can be applied to the skin in such a way that the cosmetic sheet is directly in contact with the skin, and the substrate sheet can be applied to the skin. removed by peeling the cosmetic sheet or washing with water, if the cosmetic sheet is hydrophobic and the substrate sheet is water-soluble. Therefore, the cosmetic sheet alone can be left on the skin.
Examples [0124] The present invention will be described in detail by way of examples, in which, however, they are not to be construed as limiting the scope of the present invention.
Example 1 [0125] An aqueous solution of chitosan (1 mg / ml, 1% (v / v) of acetic acid) and an aqueous solution of sodium alginate (1 mg / ml, 0.5 M NaCl) were prepared with deionized water.
[0126] A multi-layer nanometer sheet consisting of chitosan and sodium alginate was prepared using the following
37/47 steps:
(1) the formation of a chitosan layer by pouring 1 ml of the aqueous chitosan solution on the surface of the SiO2 substrate, followed by the centrifugation of the substrate, at 4,500 rpm for 20 seconds, and twice washing with deionized water and drying by centrifuging support for 30 seconds;
(2) the formation of a layer of sodium alginate, pouring 1 ml of the aqueous solution of sodium alginate on the surface of the SiO2 substrate coated with the chitosan layer, followed by centrifuging the substrate at 4,500 rpm for 20 seconds, and twice of washing with deionized water and drying by centrifuging the support for 30 seconds;
(3) the repetition of the formation of the layers above chitosan, and sodium alginate using the layer-by-layer coating method by assisted centrifugation (4,500 rpm, at 15 seconds) to obtain a desired thickness from the nanometer sheet;
(4) the termination of the layer-by-layer coating method by assisted centrifugation of the chitosan layer in the formation stage, and the drying of the chitosan layer surface by nitrogen;
(5) molding a 10% by weight aqueous solution of polyvinyl alcohol (APV) onto the multi-layer nanometer sheet, leaving the solution for 12 hours, and drying to form a PVA substrate sheet; and (6) the peeling of the multilayer nanometric sheet (2.0 * 2.0 cm ² ) with the PVA substrate sheet, which has a thickness starting at 70 pm from the SiO2 support, using tweezers.
38/47 [0127] The thickness of the multilayer nanometric sheet consisting of chitosan and sodium alginate was about 90 nm. The thickness of the nanometer sheet was determined by analyzing the cross section of the end of the nanometer sheet using atomic force microscopy (AFM).
Evaluation 1 [0128] The cosmetic sheet, which was composed of the nanometer multilayer sheet and the PVA substrate sheet, according to Example 1, was assessed as the visibility on the skin, the sensation of skin touch, the ability hiding pores in the skin and protecting the skin.
Visibility on the Skin [0129] The cosmetic sheet, according to Example 1, was applied to the face of an adult woman, and the sheet of PVA substrate was dissolved with water. On the first multi-layer nanometric sheet on the face, a second cosmetic sheet was applied, and the PVA substrate sheet was dissolved with water. By repeating this procedure once again, the three layers of the nanometric sheets were made on the face of the adult woman.
[0130] The visibility of the nanometer sheet was evaluated in each formation of a layer of the nanometer sheet on the face. This procedure was performed by five adult women, and visibility was classified as A (difficult to be recognized by three or more women), B (difficult to be recognized by two women) and C (difficult to be recognized by one or less women ).
[0131] As a control, a commercial layer auxiliary cosmetic film (DesignTape marketed by Kazuki International Corporation), according to publication WO 2009/041121 was used. A simple film
39/47 of the film was applied to the face of 5 adult women, the visibility of the film was assessed as above.
[0132] The results are shown in Table 1.
Table 1
Visibility 1 layer of leavesnanometric THE 2 layers of leavesnanometric THE 3 layers of leavesnanometric THE Control Ç
[0133] The nanometer sheet was found to be invisible even if a plurality of the nanometer sheets were applied to the skin. On the other hand, the control was visible.
[0134] In addition, the nanometer sheet did not cause any skin irritation, while the control caused some irritation.
Sensation of Touching the Skin [0135] The cosmetic sheet, according to Example 1, was applied to the face of an adult woman, and the sheet of PVA substrate was dissolved with water. On the first multi-layer nanometric sheet on the face, a second cosmetic sheet was applied, and the PVA substrate sheet was dissolved with water. By repeating this procedure once again, the three layers of the nanometric sheets were made on the face of the adult woman.
[0136] In each formation of a layer of the nanometer sheet on the face, the sensation of the touch of the skin, in which the nanometer sheet had been applied, was evaluated. This procedure was performed by five adult women, and the sensation of the touch of the skin was classified as A (soft for 3 or more women), B (soft for 2 women) and C (soft for one or less women).
40/47 [0137] As a control, a commercial layer auxiliary cosmetic film (DesignTape marketed by Kazuki International Corporation), according to publication WO 2009/041121, was used. A simple film of the film was applied to the face of 5 adult women, the sensation of the touch of the skin was assessed as above.
[0138] The results are shown in Table 2.
Table 2
Sensation of Skin Touch 1 layer of nanometric sheets THE 2 layers of nanometric sheets THE 3 layers of nanometric sheets THE Control Ç
[0139] The nanometer sheet has been found to provide a very smooth feeling of skin touch. On the other hand, control is difficult to provide a smooth feeling of skin touch.
PORE HIDING [0140] The cosmetic sheet, according to Example 1, was applied to the face of an adult woman, and the PVA substrate sheet was dissolved with water. On the first multi-layer nanometric sheet on the face, a second cosmetic sheet was applied, and the PVA substrate sheet was dissolved with water. By repeating this procedure once again, the three layers of the nanometric sheets were made on the face of the adult woman.
[0141] In each formation of a layer of the nanometric sheet on the face, its ability to hide the pore was evaluated. This procedure was performed by five adult women, and the pore hiding capacity was classified as A (difficult to be recognized by three or more women), B (difficult to be recognized by two women) and C (difficult to be recognized by one or less women).
41/47 [0142] As a control, the above assessment was performed without the nanometer sheet.
[0143] The results are shown in Table 3.
Table 3
Hide capacitypore 1 layer of leavesnanometric B 2 layers of leavesnanometric THE 3 layers of leavesnanometric THE Control Ç
[0144] It was found that a single nanometer sheet had the effects of pore hiding, and that the hiding effects of the pore increased according to the number of layers of the nanometer sheet.
Skin Protection [0145] The cosmetic sheet, according to Example 1, was applied to the face of an adult woman, and the sheet of PVA substrate was dissolved with water. On the first multi-layer nanometric sheet on the face, a second cosmetic sheet was applied, and the PVA substrate sheet was dissolved with water. By repeating this procedure once again, the three layers of the nanometric sheets were made on the face of the adult woman.
[0146] In each formation of a layer of the nanometric sheet on the face, the skin's protective capacity was evaluated as follows.
[0147] A carbon black powder was applied to the nanometer sheet that had been applied to the skin. After removing the carbon black particles by washing the nanometer sheet with water, the color or darkness of the nanometer sheet was evaluated. This procedure was carried out by five
42/47 adult women, and the ability to protect the skin was classified as A (clear for 3 or more women), B (clear for 2 women) and C (clear for one or less women).
[0148] As a control, the above assessment was performed without the nanometer sheet. Consequently, a carbon black powder was applied directly to the skin. After removing the carbon black particles by washing the skin with water, the color or darkness of the nanometer sheet was evaluated as above.
[0149] The results are shown in Table 4.
Table 4
Skin Protection 1 layer of nanometric sheets THE 2 layers of nanometric sheets THE 3 layers of nanometric sheets THE Control Ç
[0150] It was discovered that even a single nanometer sheet had the skin protection effects, and that the skin protection effects increased according to the number of the nanometer sheet layers.
EXAMPLE 2 [0151] An aqueous solution of chitosan (1 mg / ml, 1% (v / v) of acetic acid) and beta-cyclodextrin (0.2 mg / ml) and an aqueous solution of sodium alginate (1 mg / mL, 0.5 M NaCl) and beta cyclodextrin (0.2 mg / mL) were prepared with deionized water.
[0152] A multi-layer nanometer sheet consisting of chitosan, sodium alginate, and beta-cyclodextrin was prepared in the following steps:
(1) the formation of a layer of chitosan + betacyclodextrin pouring 1 ml of the aqueous solution of chitosan and beta43 / 47 cyclodextrin on the surface of the S1O2 substrate, followed by centrifuging the substrate at 4,500 rpm for 20 seconds, and twice washing with deionized water and drying by centrifuging the support for 30 seconds;
(2) the formation of a layer of sodium alginate + beta-cyclodextrin by pouring 1 ml of the aqueous solution of sodium alginate and beta-cyclodextrin on the surface of the SiO2 substrate coated by the layer of chitosan + beta-cyclodextrin, followed by centrifugation of the substrate, 4,500 rpm for 20 seconds, and twice of washing with deionized water and drying by centrifuging the support for 30 seconds;
(3) the repetition of the formation of the layers above chitosan + beta-cyclodextrin and sodium alginate + beta-cyclodextrin using the layer-by-layer coating method by assisted centrifugation (4,500 rpm, at 15 seconds) to obtain a thickness from desired size of the nanometer sheet;
(4) the termination of the layer-by-layer coating method by assisted centrifugation using chitosan + beta-cyclodextrin in the formation step, and the drying of the chitosan + beta-cyclodextrin layer surface by nitrogen;
(5) molding a 10% by weight aqueous solution of polyvinyl alcohol (APV) onto the multi-layer nanometer sheet, leaving the solution for 12 hours, and drying to form a PVA substrate sheet; and (6) the peeling of the multilayer nanometric sheet (2.0 * 2.0 cm ² ) with the PVA substrate sheet, which has a thickness starting at 70 pm from the SiO2 support, using tweezers.
44/47 [0153] The thickness of the multilayer nanometric sheet consisting of chitosan, sodium alginate, and beta-cyclodextrin was about 100 nm. The thickness of the nanometer sheet was determined by analyzing the cross section of the end of the nanometer sheet using atomic force microscopy (AFM).
[0154] The amount of beta-cyclodextrin in the nanometric sheet (chitosan and sodium alginate) was determined using an HPLC method, and was found to be about 10% by weight.
Assessment 2 [0155] Two cosmetic sheets, which were composed of the multi-layer nanometric sheet and the PVA substrate sheet, according to Examples 1 and 2 were assessed for their ability to control the bad smell associated with underarm perspiration.
[0156] Each of the cosmetic sheets (2.0 * 2.0 cm ² ), according to Examples 1 and 2, was applied over the armpit of an adult man, and the PVA substrate sheet was dissolved with water. After 6 hours, the smell of the armpit was assessed. This procedure was performed by five adult men, and the ability to control bad odor was classified as A (no smell), B (little smell) and C (strong smell).
[0157] As a control, the above assessment was carried out without the cosmetic sheet.
[0158] The results are shown in Table 5.
Table 5
Smell control Example 1 B Example 2 THE Control Ç
[0159] It was found that cosmetic sheets, according to
45/47, Examples 1 and 2, in particular Example 2, were effective in reducing or eliminating the stench of perspiration.
[0160] In addition, the cosmetic sheets, according to Examples 1 and 2, did not cause any skin irritation.
Example 3 [0161] An aqueous solution of chitosan (1 mg / mL, 1% (v / v) of acetic acid) and ascorbic acid 3-O-acetate (0.2 mg / mL) and an aqueous solution of alginate of sodium (1 mg / mL, 0.5 M NaCl) and 3-Oacetate ascorbic acid (0.2 mg / mL) were prepared with deionized water.
[0162] A multi-layer nanometer sheet consisting of chitosan, sodium alginate, ascorbic acid and 3-O-acetate was prepared with the following steps:
(1) the formation of a layer of ascorbic acid chitosan + 3-O-ethyl, pouring 1 ml of the aqueous solution of chitosan and ascorbic acid of 3-O-ethyl on the surface of the SiO2 substrate, followed by centrifugation of the substrate, at 4,500 rpm for 20 seconds, and twice with washing with deionized water and drying by centrifuging the support for 30 seconds;
(2) the formation of a layer of sodium alginate + 3-O-ethyl ascorbic acid, pouring 1 ml of the aqueous solution of sodium alginate and 3-O-ethyl ascorbic acid on the surface of the SiO2 substrate, coated by chitosan + 3-O-ethyl ascorbic acid layer, followed by centrifugation of the substrate, at 4,500 rpm for 20 seconds, and twice washing with deionized water and drying by centrifuging the support for 30 seconds;
(3) the repetition of the formation above the layers of chitosan + 3-O-ethyl ascorbic acid and sodium alginate + 3-O-ethyl ascorbic acid using the layer-by-layer coating method by centrifugation
46/47 assisted (4,500 rpm, at 15 seconds) to achieve a desired thickness of the nanometer sheet;
(4), the end of the layer-by-layer coating method by assisted centrifugation in the chitosan layer + 3-Oethyl ascorbic acid in the formation phase, and the drying of the surface of the chitosan layer + 3-O- ascorbic acid nitrogen ethyl;
(5) molding a 10% by weight aqueous solution of polyvinyl alcohol (APV) onto the multi-layer nanometer sheet, leaving the solution for 12 hours, and drying to form a PVA substrate sheet; and (6) the peeling of the multilayer nanometric sheet (2.0 * 2.0 cm ² ) with the PVA substrate sheet, which has a thickness starting at 70 pm from the SiO2 support, using tweezers.
[0163] The thickness of the multi-layer nanometer sheet consisting of chitosan, sodium alginate, ascorbic acid and 3-O-acetate was about 100 nm. The thickness of the nanometer sheet was determined by analyzing the cross section of the end of the nanometer sheet using atomic force microscopy (AFM).
[0164] The amount of ascorbic acid 3-O-ethia in the nanometric sheet (chitosan and sodium alginate) was determined using an HPLC method, and was found to be about 10% by weight.
Evaluation 3 [0165] Two cosmetic sheets, which were composed of the nanometer multilayer sheet and the PVA substrate sheet, according to Examples 1 and 3, were evaluated for their skin lightening ability.
[0166] Each of the cosmetic sheets (2.0 * 2.0 cm ² ), according to Examples 1 and 3 was applied on the lower arm of an adult,
47/47 and the PVA substrate sheet was dissolved with water. Then, the UVB light with an intensity of about 2 times in the minimum erythema dose was irradiated in the nanometer sheet to induce the darkness of the skin. This procedure was performed by 10 men and 10 women, and repeated for 4 weeks.
[0167] After 4 weeks, skin color was measured with a colorimeter (SPECTRO PHOTOMETER, CMS-35FS, Murakami Research Laboratory Color). Specifically, the colorimeter was used to determine the contrast of the skin color, therefore, evaluating the effects of the nanometer sheet. The L * value was measured and used as an index of skin color contrast. The difference in the L * (AL *) value in the skin color between before and after 4 weeks (AL * = L * after 4 weeks - L * before 4 weeks) was calculated based on the measured values of L *.
[0168] As a result, it was found that the AL * for the cosmetic sheet, according to Example 3, was lower than for the cosmetic sheet, according to Example 1. Therefore, it was recognized that the use of cosmetic sheet, according to Example 3, reduces skin pigmentation.
[0169] In addition, cosmetic sheets, according to Examples 1 and 3, did not cause any skin irritation.
1/4

权利要求:
Claims (16)
[1]
Claims
1. COSMETIC PROCESS FOR SKIN, characterized by the process comprising the stage of:
application on the skin of a cosmetic sheet comprising at least one biocompatible and / or biodegradable hydrophobic polymeric layer, which alters the sensation of skin touch, which hides the appearance of wrinkles and / or pores, and / or protects the skin from pollution and / or contaminants, where:
the cosmetic sheet is self-sustaining, the biocompatible and / or biodegradable hydrophobic polymer comprises a non-crosslinked polymer selected from:
non-crosslinked poly (lactic acid) and its derivatives and at least one cationic polymer and at least one anionic polymer, the self-sustaining cosmetic sheet has a thickness of 10 to
1,000 nm.
[2]
2. COSMETIC PROCESS FOR SKIN, characterized by the process comprising the application of a cosmetic sheet on the skin, which comprises at least one biocompatible and / or biodegradable hydrophobic polymeric layer, and which absorbs sebum on the skin, which controls perspiration on the skin. skin, which controls odors on the skin, and / or which provides at least one cosmetic active ingredient through the skin, where:
the cosmetic sheet is self-sustaining, the biocompatible and / or biodegradable hydrophobic polymer comprises a non-crosslinked polymer selected from:
non-cross-linked poly (lactic acid) and its derivatives, and at least one cationic polymer and at least one anionic polymer,
Petition 870180039927, of 05/14/2018, p. 15/23
2/4 the self-sustaining cosmetic sheet has a thickness of 10 to 1,000 nm, and the cosmetic sheet comprises at least one cosmetic active ingredient selected from antiseptic agents, anti-acne agents, deodorant agents, antiperspirants, antibacterial agents, bleaching agents or mixtures thereof where at least one cosmetic active ingredient is incorporated into at least one biocompatible and / or biodegradable polymer.
[3]
PROCESS according to any one of claims 1 to 2, characterized in that the biocompatible and / or biodegradable hydrophobic polymeric layer is non-cross-linked, preferably selected from non-cross-linked poly (lactic acid) and derivatives thereof.
[4]
PROCESS according to any one of claims 1 to 2, characterized in that the biocompatible and / or biodegradable hydrophobic polymeric layer comprises at least one cationic polymer and at least one anionic polymer.
[5]
5. PROCESS, according to claim 4, characterized in that the cationic polymer has at least one positively chargeable portion, selected from the group consisting of a quaternary ammonium group, a guanidine group, a biguanide group, an imidazole group, an imino group , a pyridyl group and an amino group.
[6]
6. PROCESS according to any one of claims 4 to 5, characterized in that the cationic polymer is selected from the group consisting of chitosan, collagen, polyalylamines, polyvinylamines, polydiallyldialkylammonium chloride, polyanilines, polyvinylimidazoles, polydimethylaminoethylenemetacrates, methyl-2-vinylpyridine, polyamines, polyimines, polyethyleneimines, polyvinylpyridines, poly (pyridine quaternary), polylysines, polyvinitines, polyarginines, polyhiistidines, polyaminopropyl
Petition 870180039927, of 05/14/2018, p. 16/23
3/4 biguanides, and salts thereof.
[7]
7. PROCESS according to any one of claims 4 to 6, characterized in that the anionic polymer has at least one negatively chargeable portion, selected from the group consisting of a sulfuric group, a sulfate group, a sulfonic group, a sulfonate group , a phosphoric group, a phosphate group, a phosphonic group, a phosphonate group, a carboxylic group and a carboxylate group.
[8]
8. PROCESS according to any one of claims 4 to 7, characterized in that the anionic polymer is selected from the group consisting of alginic acid, hyaluronic acid, polyglutamic acids, polylactic acids, polyglycolic acids, polycaprolactones, poly (met) acids acrylics, polyamic acids, polystyrene sulphonate, poly (vinyl sulphate), dextran sulphate, chondroitin sulphate, polymalleic acids, polyfumaric acids, carboxy methyl cellulose, maleic anhydride styrene derivatives and their salts.
[9]
PROCESS according to any one of claims 2 to 8, characterized in that the cosmetic active ingredient is a tallow crystallization agent.
[10]
PROCESS according to any one of claims 2 to 8, characterized in that the cosmetic active ingredient is a deodorant agent, an antiperspirant agent, or an antibacterial agent.
[11]
11. PROCESS, according to claim 10, characterized in that the deodorant agent is selected from the cyclodextrins and derivatives thereof.
[12]
12. PROCESS according to any one of claims 2 to 8, characterized in that the cosmetic active ingredient is an anti-aging agent or a bleaching agent.
[13]
13. PROCESS, according to any of the
Petition 870180039927, of 05/14/2018, p. 17/23
4/4 claims 2 to 12, characterized in that the amount of the active cosmetic ingredient (s) is 0.01 to 30% by weight, preferably 0.05 to 20% by weight and more preferably 0.1 to 10% by weight, based on the total weight of the cosmetic sheet.
[14]
14. PROCESS according to any one of claims 1 to 13, characterized in that the cosmetic sheet is attached to a substrate sheet.
[15]
15. PROCESS, according to claim 14, characterized in that the cosmetic sheet is detachable from the substrate sheet.
[16]
16. COSMETIC LEAF FOR SKIN, characterized by comprising:
at least one biocompatible and / or biodegradable hydrophobic polymeric layer, where:
the cosmetic sheet is self-sustaining, the biocompatible and / or biodegradable hydrophobic polymer comprises a non-crosslinked polymer selected from:
non-crosslinked poly (lactic acid) and its derivatives, and at least one cationic polymer and at least one anionic polymer, the cosmetic sheet has a thickness of 10 to 1,000 nm, and the cosmetic sheet comprises at least one cosmetic active ingredient selected from anti-sebum agents, anti-acne agents, deodorant agents, antiperspirant agents, antibacterial agents, bleaching agents or mixtures thereof, where the at least one cosmetic active ingredient is incorporated within the at least one biocompatible and / or biodegradable polymer.
Petition 870180039927, of 05/14/2018, p. 18/23
1/1

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JP2019001726A|2017-06-13|2019-01-10|ロレアル|Composition comprising poly-ion complex particles and oil|

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JP2019001727A|2017-06-13|2019-01-10|ロレアル|Combination of poly-ion complex particles and non-polymer base having two or more dissociation constants|

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JP2019104701A|2017-12-12|2019-06-27|ロレアル|Composition comprising oil and polyion complex comprising cellulosic cationic polymer having at least one aliphatic chain|

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法律状态:
2018-02-14| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|

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2018-06-05| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2018-07-17| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|

优先权:

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申请号 | 申请日 | 专利标题

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PCT/JP2012/060392|WO2013153678A1|2012-04-11|2012-04-11|Self-standing cosmetic sheet|

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