• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    surgical implant. the present invention relates to a surgical implant (10) that has a basic surface structure (12) provided with pores (14). at least one projection (16, 17), which emerges at an angle of at most 40° from the plane defined by the basic surface structure (12) in the local environment of the projection (16, 17), projects in at least one of the pores (14). preferably, the at least one projection (16, 17) is produced from the material of the basic structure (12), part of the edge of the pore (14) and is located in the area defined by the basic structure (12).
    公开号:BR112014023567B1
    申请号:R112014023567-8
    申请日:2013-03-21
    公开日:2022-01-04
    发明作者:Joerg PRIEWE
    申请人:Johnson & Johnson Medical Gmbh；
    IPC主号:
    专利说明:

    [001] The invention relates to a surgical implant with a basic surface structure provided with pores.
    [002] Surgical implants for soft body tissue, eg hernia implants, are often difficult to position in the intended location. Fixation means such as staples or sutures are generally necessary to maintain the implant in a flat or superficial installed state and to prevent it from moving in body tissue before it is incorporated. This can lead to complications in the surgical operation or it can cause side effects.
    [003] WO 2003/099160 A1 discloses a medical implant in the form of a knotted film. The nodes provide the implant with greater flexibility.
    [004] Document No. WO 2010/086515 A1 discloses an implantable plate with a textile substrate, whose plate is provided, on at least one of its surfaces, with a series of projections intended to prevent the implant from slipping. These projections are produced by punching, a perforation being formed, in each case, in the center of a dam-shaped projection. Projections protrude from the plate plane at an angle in the range of 45° to 90°.
    [005] Document No. US 7 331 199 discloses a textile implant with projections that project perpendicularly to the flat implant, with a head that rests on the free ends of each of the projections.
    [006] Document no. EP 2 368 524 A2 discloses a surgical implant comprising a substrate, the surface of which is provided with projections made of a memory material. When the implant is fitted, the projections are completely flat. A change in temperature causes the projections to curve upward at steep angles to anchor the implant in body tissue.
    [007] The aim of the invention is to provide a surgical implant that automatically attaches at least partially to body tissue and that can be easily produced.
    [008] This objective is achieved by a surgical implant that has the features according to claim 1. Advantageous embodiments of the invention are presented in the dependent claims.
    [009] The surgical implant according to the invention comprises a basic surface structure provided with pores. At least one projection projects into at least one of the pores. From the plane defined by the basic surface structure in the local environment of the projection, it emerges at an angle α of at most 40°. The maximum value of angle α can also be given by any value smaller than 40°, in particular by one of the values contained in the following list: 38°, 36°, 34°, 32°, 30°, 28°, 26° , 24°, 22°, 20°, 18°, 16°, 14°, 12°, 10°, 8°, 6°, 4°, 2°.
    [0010] In the advantageous embodiments of the invention, the at least one projection is located in the area defined by the basic structure, that is, the angle α is very small, practically zero, or zero, as long as the projection is not curved.
    [0011] The basic structure is shallow in the sense that its thickness is generally small (e.g. less than 1 mm) compared to its extent in the length direction and width direction (e.g. more than 1 mm). than 1 mm and, in most cases, significantly more than 1 mm).
    [0012] The implant according to the invention is suitable, in particular, as a hernia mesh, but other uses are similarly conceivable, including as part of a medical implant that has additional components. In principle, the implant is designed for implantation into human or mammalian tissue.
    [0013] The pores of the basic structure can, in principle, have any shape and can be arranged in any pattern. The shape and arrangement of the pores give the basic structure elasticity and adaptability due to the anatomical circumstances at the implantation site.
    [0014] One or more projections project into a given pore of the basic structure, although it is also possible that no projection projects into a given pore. In general, a series of pores in the basic structure is provided with one or more projections. The individual projections may be differently configured and/or extend in different directions.
    [0015] Projections increase friction when an attempt is made to pull the implant through body tissue, particularly when the implant is pulled towards the free end of a projection, as the free end can then hook or secure at least temporarily in body tissue. If a series of projections are present, the friction behavior of the basic structure can be predefined by the directions of the projections (see also below). With the aid of the projections, the implant according to the invention is thus substantially and automatically attached to the body tissue, at least in directions predetermined by the orientation of the projections.
    [0016] Therefore, during the operation to fit the implant according to the invention in place, it is possible to do this without fixing means, such as sutures or staples, thus accelerating the course of the operation. In the initial phase after the operation, the tissue can pass through the pores of the basic structure, without obstruction by additional means of fixation, so that the implant is incorporated and can fulfill its real purpose, that is, to support the treated body tissue. .
    [0017] In the advantageous embodiments of the invention, the at least one projection is produced from material of the basic structure and part of the pore edge. In this way, at least one projection can be made on a part with the basic structure, for example, by cutting from the basic structure. It is particularly advantageous if the basic structure is designed as a film, from which the pores are cut in such a way as to leave the projections projecting into the pores. The term "cut" is to be understood here in the geometric sense and is not limited to a cutting technique. Implants of this type are easy to produce and can be used as implants similar to an implant mesh. The stretching behavior of the backbone is particularly favorable if the backbone, opposite where the at least one projection starts from the edge of the pore, has a recess, which is preferably designed as part of a pore adjacent to the pore.
    [0018] The pore size can be at least 1mm. The "size" of a pore is to be understood as a typical measurement of length, e.g. the lateral length in the case of a substantially square pore, and the length of the longest side in the case of a rectangular pore, which, in any case, is not very long in practice. A projection can have a length that is at least half the size of the pore to which it projects. The length of a projection is, for example, at least 1 mm. Pores and projections of such sizes are easy to produce and show the desired effect on the implant.
    [0019] In preferred embodiments of the implant according to the invention, the at least one projection tapers towards its free end. In projections modeled in this way, the friction effect increases if the implant is pulled through body tissue toward the free ends of the projections. However, the free ends of the projections should not be tapered to such an extent that surgical gloves are damaged during handling of the implant. Glove damage can also be avoided if the projections are made of relatively soft material.
    [0020] In advantageous embodiments of the implant, as already indicated, a multiplicity of pores is provided, each with at least one projection. If each projection has an oriented longitudinal axis, which follows the course of the projection to its free end, the longitudinal axes of all projections on the implant may extend in one direction or in at least two different directions.
    [0021] Modalities with only one direction of projections lead to substantial self-fixation of the implant against pulling in one direction. If the projections point in different directions, they can be arranged in patterns. An example of this is a group of pores that substantially follow the course of the circumference of a circle, with the projections pointing to the center of that circle. In general, in pores that are different from each other, the projections can extend into different areas of the pores. A number of examples of the many possibilities are explained in more detail below.
    [0022] Depending on the implant, it may also be advantageous for the projections to be arranged only in some areas of the implant. Examples of this are implants in which the pores in an implant edge zone are provided with projections, while no projections are present in a central zone of the implant.
    [0023] In an advantageous embodiment of the implant according to the invention, as already indicated, the basic structure is designed as a film (preferably not of metal), in particular as a polymer film. However, the surface structures for the basic structure can also be configured differently, for example as polymer foam or as a woven textile product, in particular as a woven, knitted or crocheted cloth. Nonwoven materials (herein referred to as polymeric nonwovens, although this is not to be understood in a restrictive sense) are similarly conceivable. It is also possible to use laminates of various surface structures with identical types (eg film on film) and also with different types (eg knitted film) of the aforementioned surface structures.
    [0024] In advantageous embodiments of the invention, the at least one projection is strengthened, for example, with a coating or by thermoforming. A coating can, for example, be applied locally to a basic structure that is projected as a film and from which the pores with projections are cut, e.g. applied only to the projections and, if appropriate, also to the initial area of the projections. . A thickening of the material in the area of the projections can also be achieved by thermoforming.
    [0025] In principle, the basic surface structure can have many large formats. For example, in addition to compact square, round or rectangular shapes, it is also possible to consider using elongated shapes, in particular shapes in which the length of the basic structure is at least three times the size of the width. Implants of this type can be used as implant strips and, in the case of very elongated shapes, also as surgical suture materials.
    [0026] Many materials can be considered for use as the material for the basic structure, eg preferably polymers. These may be synthetic or biologically generated, resorbable or non-resorbable polymer materials.
    [0027] Examples of non-resorbable polymers are: polyalkanes, polypropylene, polyethylene, partially hydrogenated polyolefins, fully hydrogenated polyolefins, fluorinated polyolefins, polytetrafluoroethylene, polyvinylidene fluoride, polyisoprenes, polystyrenes, polysilicones, polycarbonates, polyaryletherketones , polyurethanes, polymethacrylates, polyacrylates, polyimides, cross-linked hydrophilic polymers, and silicones, and also copolymers of polymerizable substances thereof.
    [0028] Examples of resorbable polymers are: polyhydroxy acids, polylactides, polyglycolides, polyhydroxybutyrates, polyhydroxyvalerates, polycaprolactones, polydioxanones, synthetic and natural oligo and polyamino acids, polyphosphazenes, polyanhydrides, polyortho-esters, polyphosphates, polyphosphonates, polyalcohols, polysugars, polyethers, polyamides, aliphatic polyesters, aromatic polyesters, natural polyamino acids, synthetic polyamino acids, genetically engineered polyamino acids, collagen, rh collagen, silk, pseudo-polyamino acids, polycyanoacrylates, polyethylene glycols, polyvinyl alcohols, cellulose derivatives, polyphosphate esters, and also copolymers of polymerizable substances thereof. Resorbable glasses can also be used.
    [0029] It is also conceivable to use different materials, including the simultaneous use of non-resorbable and resorbable materials.
    [0030] In the advantageous embodiments of the invention, the basic structure contains different materials, of which at least one is resorbable, and the at least one projection has this resorbable material. In implants of this type, the degradation profile over time can be specifically defined. For example, projections can be degraded more quickly than the rest of the basic structure, as projections are often only needed at the beginning of the healing process, since sufficient body tissue has not yet grown through the implant.
    [0031] The implant may also have additional barbs, which are not formed from the projections discussed above. The additional barbs can, for example, be applied as add-on pastes to the basic structure.
    [0032] In many embodiments of the implant according to the invention, the implant mainly consists of the basic structure and the projections that project into the pores, which projections can be made of the material of the basic structure. In other embodiments, the implant is used as part of a medical implant that has additional components.
    [0033] An example is a film with pores, from whose film projections are formed and which is connected to an additional implant mesh which, in this case, substantially contributes to the mechanical properties of the implant. In that case, it is conceivable to cover both sides of the additional implant mesh with a film that has pores and projections. In this way, it is possible for several implants, each with a basic structure and projections, to be used in a larger medical implant. In addition to implant meshes, other examples of medical implants of this type are: Catheters, tubes, breast implants, and so on. In all these cases, the projections can contribute to the fast and dry fixation of the medical implant in its desired location.
    [0034] Several methods are described below to produce a surgical implant according to the invention that has a basic surface structure with pores (holes) and projections.
    [0035] In cutting methods, pores are cut from a surface structure (e.g. a sheet or a film), methods from which the at least one projection that projects into a respective pore and part of the edge of the pore is not cut. Conventional cutting methods are laser cutting, waterjet cutting, ultrasonic cutting, plasma cutting, mechanical cutting, thermal cutting, punching and micro-milling. Due to a melting process in the area of the cut line, laser cutting methods can also induce partial thickening and therefore projection stiffening.
    [0036] In molding methods, a suitable mold is first produced. The mold is filled with liquid plastic (molten material or solution), which then hardens or is hardened. This category also includes injection molding methods.
    [0037] Additional methods that may be mentioned are polymerization in a mold, remelting in a power source mold, and printing techniques in which, for example, a reinforcing layer is printed on the projections.
    [0038] As already indicated, examples of possible surface structures for the basic structure are polymer films (preferably biaxially stretched films or sheets), foams, nonwovens, or condensed textiles (e.g. condensed cPTFE or ePTFE). Fiber reinforced composite films can also be used. For example, a fabric "Vicryl" membrane ("Vicryl": lactide and glycolide copolymer) can be coated with a polylactide-co-glycolide of a suitable solvent, such as acetone, ethyl acetate or dichloromethane; if the solvent is evaporated, a resorbable polymer film is obtained which is strengthened by a resorbable textile product; this composite film can also be provided with pores (holes) and recesses by the methods discussed.
    [0039] Implants according to the invention can also be produced from biological material in accordance with the invention, for example by means of collagen, for example by being poured into a suitable mold, subjected to drying and optionally cut. It is also possible to machine biological implants, eg "Surgisis" (Cook) or "Strattice" (LifeCell), using the aforementioned punching or cutting methods.
    [0040] An implant in which the projections degrade differently from the base structure after implantation can be produced as follows for example: The base structure is a surface structure with regular pores (e.g. hexagonal, round, rhomboid) that is produced first. In a second step, projections are added in part (as toothed projections), via the surface structure which is placed in a toothed projection mold and dripped onto the tooth area with a polymer solution or molten material. Depending on the material, tooth-shaped projections have different mechanical behavior or degradation behavior.
    [0041] If a surgical implant according to the invention is to be used as part of a medical implant with additional components (e.g. a conventional hernia mesh), common joining techniques are suitable for connection to the other components, for example joining adhesive, ultrasonic welding, plasma welding, lamination, sewing and/or embroidery.
    [0042] The invention is described in more detail below based on illustrative embodiments. In the figures:
    [0043] Figure 1 shows an overview of an embodiment of the surgical implant according to the invention in a plan view, approximately the original size,
    [0044] Figure 2 shows an enlarged detail of another embodiment of the implant according to the invention in an oblique view,
    [0045] Figure 3 shows an enlarged detail of another embodiment of the implant according to the invention in an oblique view,
    [0046] Figure 4 shows, in parts (a) to (d), plan views of other modalities of the implant according to the invention,
    [0047] Figure 5 shows, in parts (a) to (h), schematic views of examples of different pore shapes in implants according to the invention, with one or two projections being provided in each case,
    [0048] Figure 6 shows an enlarged detail of a modality of a medical implant in which an implant according to the invention is connected to a conventional implant mesh, in a three-dimensional systematic view,
    [0049] Figure 7 shows an enlarged detail of another embodiment of the implant according to the invention in a plan view,
    [0050] Figure 8 shows an enlarged detail of another embodiment of the implant according to the invention in a plan view, and
    [0051] Figure 9 shows a diagram illustrating the forces that occur in mouse skin upon displacement of the modalities according to Figure 7 and Figure 8 and of a conventional comparison implant.
    [0052] In Figure 1, an embodiment of a surgical implant 1 is shown in a plan view, approximately the original size.
    [0053] The implant 1 has a rectangular basic structure 2 with an edge 3, and the basic structure 2, in the illustrative embodiment, is produced from a film. A plurality of pores 4 are cut from the area of the basic structure 2. A projection 6 projects into each of these pores 4 and, in the illustrative embodiment, is projected as a double projection (or two projections), part of the edge of the pores 4 and extends in the plane of frame 2 (unless it is curved). A pore of implant 1 appears with its double projection in an enlarged view, as shown in Figure 5(b). In implant 1, projections 6 are oriented parallel to each other, i.e. they all extend in the same direction.
    [0054] Figure 2 shows a detail of an additional implant 10 in an oblique view. The implant 10 contains a basic structure 12 provided with hexagonal pores 14, in each of which a projection 16 or a projection 17 projects. Projections 16 and 17 are oriented antiparallel to each other, that is, their free tapered ends point in diametrically opposite directions. Each of the projections 16, 17 has a triangular recess 18.
    [0055] Figure 3 shows a detail of an additional implant 20, again in an oblique view. The implant 20 has a basic structure 22 provided with hexagonal pores 24, the central pore of which is designated 25. The arrangement of the pores 24, 25 shown in Figure 3 is repeated throughout the implant 20, since the hexagonal arrangements of this type make it possible to fill an area without leaving gaps. As can be seen in Figure 3, a projection starting from the edge of the pore 24 and having two protuberances 28 at the free end projects into each of the pores 24. The projections 26 are all directed towards the central pore 25, and there is no projection that projects to the central pore itself. The directions of the projections 26 are therefore different. This provides effective fixation of the implant 20 against slippage in all directions.
    [0056] Figure 4 shows, in parts (a), (b), (c) and (d), four implants 30, 31, 32 and 33, respectively, which are all constructed of similarly designed sections. Each of these sections contains a pore 34 in an area 35 of the basic structure. Two projections 36, 37 with round free ends project into each of the pores 34. The open area of each pore 34 is thus shaped like a letter "E".
    [0057] The implants 30 and 31 according to Figures 4(a) and 4(b), respectively, are elongated, and the implant 31 is provided with a connecting bridge 38, in each case, between two adjacent sections with pores 34. The implant 32 according to Figure 4(c) is rectangular. In the implant 33 according to Figure 4(d), the sections with the pores 34 are arranged as a circle, with the implant 33 having a larger central recess 39.
    [0058] Figure 5 shows, in parts (a) to (h), additional illustrative modalities of pores, in each of which at least one projection is projected. For the sake of simplicity, all pores are designated here by 40, their edges by 42, and projections by 44. Each of the projections 44 starts from the edge 42 of a pore 40. In the illustrative embodiment according to Figure 5( b), there are two projections or a double projection (see also Figure 1). The same applies to the illustrative embodiment according to Figure 5(e), in which case the pore 40 is further extended into two recesses 46 (in this connection, see also the illustrative embodiment according to Figure 7). In the case of the illustrative embodiment according to Figure 5(h), a recess 48 is located within the projection, as a result of which the projection is effectively made lighter. Similarly, many other forms of pores with projections are possible.
    [0059] Figure 6 shows an enlarged detail of a medical implant 50, which is constructed of two parts. Situated at the top in Figure 6, and shown partially cut away, is a basic structure 52 produced from a film and having pores 54, in some of which a projection 56 partially projects. Projections 56 are tapered and are arranged in two groups with diametrically opposite directions. This first part corresponds to an implant of the type explained above. Situated below in Figure 6, and more clearly visible due to the fact that part of the base frame 52 has been cut, there is a conventional implant mesh 58 as a second part of the medical implant 50. The implant mesh 58 which is joined to the base structure 52 by sewing, for example, mainly determines the mechanical properties of the medical implant 50 while the basic structure 52 with the projections 56 facilitates the fixation.
    [0060] More consecutively numbered examples of specific modalities follow. Example 1
    [0061] A laser (CadCam) was used to cut a pore structure from a rectangular polypropylene film approximately 120 μm thick that measures 10 cm x 15 cm and serves as the basic structure. Each of the pores had a basic hexagonal shape with a height of 3 mm and a width of 2 mm, and a flat triangular projection that has a length of approximately 1.1 mm, and which starts from the pore edge on the right side ( in the view according to Figure 7), projected into each pore. On the opposite pore side, a triangular recess with a length of approximately 1.4 mm was cut in each case.
    [0062] The result is shown in Figure 7, in which the implant is designated by 60, the basic structure by 62, the pores by 64, and the projections by 66, while the triangular recesses located on each opposite of the projections and coming out of a respective adjacent pore are designated by 67. The flexibility of the basic structure 62 is increased by the recesses 67. Example 2
    [0063] A laser (CadCam) was used to cut a pore structure from a rectangular polypropylene film approximately 120 μm thick that measures 10 cm x 15 cm and serves as the basic structure. Each of the pores had a basic hexagonal shape with a height of 3 mm and a width of 3 mm. A flat, triangular projection that has a length of approximately 1.1 mm projected into each pore. In the pores on the right side of the implant (in the view according to Figure 8), the projections started from the pore edge on the right side, and in the pores on the left side of the implant, the projections started from the pore edge on the left side. Thus, each of the free ends of the projections pointed to the center of the implant, that is, to a central axis.
    [0064] A detail of this implant is shown in Figure 8, in which the implant is designated by 70, the basic structure by 72, the pores by 74, and the projections by 76 and 77. The projections 76 on the right side of the implant point towards to the left, while the projections 77 on the left side point to the right.
    [0065] As a result of a melting process in the area of the cutting line, laser cutting techniques can lead to partial thickening and therefore stiffening of the projections. Thus, in Examples 1 and 2, the lengths of the projections were approximately 1.0 mm to 1.3 mm, that is, slightly shorter than could be expected from the original 1.5 mm laser cut standard. The fusion process can also lead to partial deformation of the projections, for example partial lifting at the free ends, or surface changes, all of which can lead to an improvement in implant properties. Example 3
    [0066] The implants of example 1 and example 2 were tested in the rat skin friction model according to WO 2006/092236 A1. A film analogous to example 2, with hexagonal pores having a height of 3 mm and a width of 3 mm, but without projections, served for comparison.
    [0067] The results for the three implants tested are shown in Figure 9, in which the measured friction force (in N) is in each case sketched over the displacement trajectory (in mm).
    [0068] The implant of example 1 (all projections in one direction) showed a sharp increase in force from the beginning to approximately 20 N when the mouse skin moved against the direction of the projections. The increase is explained by the fact that, under the given test conditions, more and more projections came into contact with the mouse skin as the displacement increased, until this applied to all projections.
    [0069] The implant of example 2 (projections in opposite directions) was initially moved relative to the mouse skin opposite the direction of the projections, so that the projections showed little effect and the friction behavior largely corresponded to the comparison film. Only when the projections came into contact with the mouse skin with their free extremities did the force increase dramatically rise to approximately 10 N. Example 4
    [0070] The implant of example 1 was placed in different layers of pork belly (contact with fat and contact with muscle). Slight pressure without traction has already resulted in a binding of the basic structure. With a pulling direction against the projections, the implant was fixed. With traction in the opposite direction, the implant was released again. There was good adhesion in different tissue (fat and muscle). Example 5
    [0071] An additional implant was produced analogously to example 1, but the material used for the basic structure was a 150 μm thick film of poly-p-dioxanone resorbable material. The implant showed good adhesion in the rat skin test (analogous to example 3). Example 6
    [0072] Analogously to document no. WO 2011/159700 A1, a medical implant was produced as laminated with a conventional polypropylene surgical mesh between two 20 μm thick sheets of a polyglycolide-co-caprolactone. A perforated film of polyp-dioxanone, about 8 μm thick, served as a hot melt adhesive. The two polyglycolide-co-caprolactone sheets had pores and projections according to example 2, with a basic hexagonal shape measuring 3 mm x 3 mm, and with triangular projections measuring approximately 1.0 mm to 1.5 mm in length. and which were fully pointed in one direction.
    权利要求:
    Claims (18)
    [0001]
    1. Surgical implant with a basic surface structure (2; 12; 22; 35; 52; 62; 72) with pores (4; 14; 24; 34; 40; 54; 64; 74), in which at least a projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) made from a base frame material (2; 12; 22; 35; 52; 62; 72) begins from the edge of at least one of the pores (4; 14; 24; 34; 40; 54; 64; 74) and projects into the pore (4; 14; 24; 34; 40; 54; 64; 74), in which the projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) emerges at an angle (α) of at most 40° from the plane defined by the basic surface structure (2; 12; 22; 35; 52; 62; 72) in the local environment of the projection, characterized by the fact that the pores (4; 14; 24; 34; 40; 54; 64; 74) are cut from a basic structure surface (2; 12; 22; 35; 52; 62; 72) of a film, a polymer foam, a textile fabric, or a laminate thereof, so as to leave at least one projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) of the basic structure (2; 12; 22; 35; 52; 62; 72) projecting into the basement (4; 14; 24; 34; 40; 54; 64; 74).
    [0002]
    2. Implant, according to claim 1, characterized in that the maximum value of the angle (α) is given by one of the values contained in the following list: 38°, 36°, 34°, 32°, 30° , 28°, 26°, 24°, 22°, 20°, 18°, 16°, 14°, 12°, 10°, 8°, 6°, 4°, 2°.
    [0003]
    3. Implant, according to claim 1, characterized in that the at least one projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) is located in the area defined by the basic structure (2; 12; 22; 35; 52; 62; 72).
    [0004]
    4. Implant, according to claim 1, characterized in that the basic structure (62) opposite to the place where the at least one projection (66) starts from the edge of the pore (64) has a recess (67) that is preferably designed as part of a pore adjacent to the pore (64).
    [0005]
    5. Implant, according to any one of claims 1 to 4, characterized in that the pore size (4; 14; 24; 34; 40; 54; 64; 74) is at least 1 mm.
    [0006]
    6. Implant according to any one of claims 1 to 5, characterized in that the at least one projection (6; 16, 17; 26; 36, 37; 44; 56; 66) has a length that is at least least half the pore size (4; 14; 24; 34; 40; 54; 64).
    [0007]
    7. Implant according to any one of claims 1 to 6, characterized in that the length of at least one projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) is at least 1 mm.
    [0008]
    8. Implant according to any one of claims 1 to 7, characterized in that the at least one projection (6; 16, 17; 44; 56; 66; 76, 77) tapers towards its free end .
    [0009]
    9. Implant according to any one of claims 1 to 8, characterized in that a plurality of pores (4; 14; 24; 34; 54; 64; 74) is provided with at least one projection (6; 16 , 17; 26; 36, 37; 56; 66; 76, 77) each.
    [0010]
    10. Implant, according to claim 9, characterized in that each projection (6; 16, 17; 26; 36, 37; 44; 56; 66; 76, 77) has an oriented longitudinal axis that follows the course from the projection to its free end, and that the longitudinal geometric axes of all projections on the implant (1; 10; 20; 30, 31, 32, 33; 50; 60; 70) extend in one direction or in at least two different directions.
    [0011]
    11. Implant according to any one of claims 1 to 10, characterized in that the basic structure (2; 12; 22; 35; 52; 62; 72) comprises one of the surface structures contained in the following list: polymeric films, polymer nonwovens, woven fabrics, warp knits, weft knits, crochets, laminates with identical or different types of the aforementioned surface structures.
    [0012]
    12. Implant according to any one of claims 1 to 11, characterized in that the at least one projection (66; 76, 77) is preferably reinforced with a coating or by thermoforming.
    [0013]
    13. Implant according to any one of claims 1 to 12, characterized in that the pores (54) in an area of the implant's edge (50) are provided with projections (56), while a central area of the implant is not is equipped with projections.
    [0014]
    14. Implant according to any one of claims 1 to 13, characterized in that the basic structure (30, 31, 32) has a length and a width, the length being at least three times the size of the width.
    [0015]
    15. Implant according to any one of claims 1 to 14, characterized in that the basic structure (2; 12; 22; 35; 52) comprises different materials, of which at least one is resorbable, and at least a projection (6; 16, 17; 26; 36, 37; 44; 56) comprises the last mentioned material.
    [0016]
    16. Implant according to any one of claims 1 to 15, characterized in that the basic structure (2; 12; 22; 35; 52; 62; 72) comprises at least one of the materials chosen from the following list: polyalkanes, polypropylene, polyethylene, partially halogenated polyolefins, fully halogenated polyolefins, fluorinated polyolefins, polytetrafluoroethylene, polyvinylidene fluoride, polyisoprenes, polystyrenes, polysilicones, polycarbonates, polyarylether ketones, polyurethanes, polymethacrylates, polyacrylates, polyimides, cross-linked hydrophilic polymers , silicones; polyhydroxy acids, polylactides, polyglycolides, polyhydroxybutyrates, polyhydroxyvalerates, polycaprolactones, polydioxanones, synthetic and natural oligo and polyamino acids, polyphosphazenes, polyanhydrides, polyorthoesters, polyphosphates, polyphosphonates, polyalcohols, polysugars , polyethers, polyamides, aliphatic polyesters, aromatic polyesters, natural polyamino acids, synthetic polyamino acids, genetically engineered polyamino acids, collagen, rh collagen, silk, pseudopolyamino acids, polycyanoacrylates, polyethylene glycols, polyvinyl alcohols, derived cellulose, polyphosphate esters ; copolymers of polymerizable substances from the above list; resorbable glasses.
    [0017]
    17. Implant according to any one of claims 1 to 16, characterized in that the implant comprises additional barbs.
    [0018]
    18. Use of a surgical implant as defined in any one of claims 1 to 17, as part of a medical implant (50), characterized in that it comprises additional components (58).
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    同族专利:
    公开号 | 公开日
    MX359283B|2018-09-21|
    WO2013139482A1|2013-09-26|
    AU2013234678A1|2014-10-30|
    NZ630130A|2015-09-25|
    MX2014011445A|2015-04-10|
    JP6158290B2|2017-07-05|
    US20140066958A1|2014-03-06|
    IN2014DN07517A|2015-04-24|
    DE102012005978A1|2013-09-26|
    EP2827798A1|2015-01-28|
    RU2647188C2|2018-03-14|
    US9949815B2|2018-04-24|
    CN104302244B|2019-01-01|
    BR112014023567A2|2017-06-20|
    CA2868152C|2020-07-14|
    AU2013234678B2|2017-02-02|
    JP2015513934A|2015-05-18|
    CA2868152A1|2013-09-26|
    RU2014142637A|2016-05-20|
    CN104302244A|2015-01-21|
    US20150066063A1|2015-03-05|
    WO2013139482A8|2014-10-02|
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    法律状态:
    2018-12-04| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-12-24| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-06-22| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2021-10-19| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2022-01-04| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/03/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102012005978.7|2012-03-23|
    DE102012005978A|DE102012005978A1|2012-03-23|2012-03-23|Surgical implant|
    PCT/EP2013/000868|WO2013139482A1|2012-03-23|2013-03-21|Surgical implant|
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