• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    catheter with antimicrobial coating. the present invention relates to a vascular fitting catheter for use in humans or animals. the catheter has at least one inner lumen defined by a side wall with a circumferential exterior. a titanium surface area is positioned along the circumferential surface, entirely or at one or both ends, to improve lubricity. additionally, an antipathogenic and / or antimicrobial surface area positioned adjacent to the titanium surface area of the circumferential surface may be included.
    公开号:BR112014022472B1
    申请号:R112014022472-2
    申请日:2013-03-13
    公开日:2021-03-23
    发明作者:Marshall Kerr
    申请人:Pfm Medical, Inc.；
    IPC主号:
    专利说明:

    [0001] [001] This application claims priority to US Provisional Patent Application Number and Series 61/610344, filed on March 13, 2012, and included in the present invention in its entirety by reference to this.
    [0002] [002] The present invention relates to catheters. More specifically, the invention relates to a catheter, such as an inserted peripheral central catheter (PICC), with an antimicrobial coating on one or both ends, to reduce the chance of pathogens being introduced into the insertion site or entering the body during insertion, removal and functional use of the PICC.
    [0003] [003] Infection of tissue in and adjacent to an insertion site, and / or a patient's vascular system can easily occur during the insertion, use and removal of a PICC or other type of catheter from a patient's body. The patient's skin, initially pierced by a needle or other intravascular access instrument to allow the insertion of a catheter through the skin and into a vein or artery, may be exposed to infectious agents such as bacteria, viruses, fungi and other localized infectious agents. on and in the vicinity of the patient's outer skin surface, in the conventional catheter, they can be easily dragged to the insertion site, through a contact with the outer surface of a catheter with the skin, during insertion, implementation and removal of the catheter after the skin barrier. This invasion of infectious agents can lead to inflammation and destruction of cells in the tissues around the puncture, or other remote infection sites, if an infectious agent carried by the catheter reaches the patient's bloodstream. The present invention provides a solution to the disadvantages of such conventional catheters by providing an infectious agent that prevents the antimicrobial coating, placed on the surfaces in contact with the skin of a catheter used in combination, to prevent the communication of agents infectious substances, such as bacteria and viruses, in the flesh below an insertion site. 2. Prior Art
    [0004] [004] Intravascular catheters, such as peripherally inserted central catheters (PICC), are forms of intravenous access normally used for chemotherapy, antibiotic therapy, prenatal nutrition and other treatments that require vascular communication from outside the patient's body. These types of catheters or channels are often used for long periods of time, which can extend up to 30 days or more. In use, the PICC or other type of catheter, must first establish communication in a vascular channel or peripheral vein, such as the cephalic vein, basilic vein or brachial vein. After the catheter that supplies the fluid channel is inserted through the skin and into the patient's vascular system, it advances towards the heart to a positioning point. At this positioning point, the tip of the needle is usually in communication positioned with the cavoatrial junction.
    [0005] [005] Conventionally, the insertion of the catheter through the skin and adjacent tissue of the vascular system is carried out by a process of several stages. This process is performed by a medical professional who uses a plurality of medical components and instruments or tools. A tool commonly used to penetrate a patient's skin and tissue is known as an introducer. The introducer is inserted through the skin and tissue, and a distal end is placed in communication with the target artery or vein of the patient's vascular system. After the introducer is properly connected, it provides a channel for the doctor to easily insert the catheter axially through it, once the target vein has been located.
    [0006] [006] To correctly insert and position the distal end of the catheter, to communicate and release the medication directly to the patient's vascular system, first, a tourniquet or similar device is applied to the patient's arm or leg in a position above the site early insertion. This interrupts blood flow, providing a means to dilate the veins to allow the medical professional to target a vein or artery of choice.
    [0007] [007] After targeting the vein or artery, an introducer needle, often called a "seldinger" needle, is fitted to a position in front of a syringe, is inserted into the target vein and the tourniquet is released. The syringe is then removed and the user seals or places his thumb over the tip of the needle to prevent blood loss or an ingestion of an air embolism.
    [0008] [008] Using a flexible guide wire, the distal end of the wire is then inserted into the needle until only the proximal end of the guide wire is visible. The guidewire is advanced with a forward motion and passes through the axis of the needle in the target vein. With the guidewire in place, the needle is removed.
    [0009] [009] The introducer, including the sheath and the dilator, passes through the proximal end of the guidewire and into the target vein. Often a doctor will cut the skin with a safety scalpel to more easily advance the dilator. Once an appropriate catheter length has been determined, the dilator is removed from the sheath. In addition, the distal tip of the catheter is inserted into and through the sheath until the tip of the catheter is correctly positioned in the target vein. The detachable sheath is then removed by pulling it out of the vessel, at the same time dividing the sheath. From this point on, adjustments can be made to the catheter as needed.
    [0010] [010] In a subsequent step, the distal tip of the catheter is inserted into and through the sheath until the tip of the catheter is correctly positioned in the target vein. The detachable sheath is then removed by pulling it out of the vessel, at the same time dividing the sheath. From this point on, adjustments can be made to position the distal end of the catheter. Once correctly positioned, it is quite common for the proximal end of the catheter to protrude from the insertion site. The proximal end can then be connected to the valves for draining fluid or introducing medication or other liquid into the catheter, as needed. As can be clearly seen, there are numerous deliberate and precise actions that take place at an insertion site in such a procedure, in order to successfully position the catheter. This being, namely, the positioning of the distal end of the catheter beyond the insertion site of the insertion site to the correct depth within the target vein to allow sufficient length of the proximal end of the catheter to continue extending from the insertion site. even after the patient's skin barrier. Although modern medicine provides a means to sterilize the catheter and other components and they are supplied in sterile packaging, there is a good chance that bacteria from the surface area will enter the insertion site on the outside surface of the catheter as it passes through the catheter. skin and into the intended blood vessel. The outer surface of the distal end of the catheter introduced after the skin barrier at the insertion site provides a surface vehicle for such infectious agents as it passes through the skin and underlying tissue barrier, and communicates through the vessel wall and inside the tensioned blood vessel. In addition, the outer surface of the proximal end of the catheter that remains outside the insertion site provides yet another carrier surface for such infectious agents.
    [0011] [011] As such, the distal end during insertion, and the proximal end being adjacent and communicating through the insertion site, can allow bacteria to be introduced into the patient.
    [0012] [012] As such, there is an ongoing unmet need for a catheter configured for use in a method that provides increased protection against the communication of pathogens and infectious agents in the patient's body. Such a device that allows for such increased preventions should provide additional means in addition to conventional sterilization techniques to prevent such infectious agents from entering a patient's underlying tissue and vascular system through an insertion site when medical devices pass through a patient's skin. . Such a device must provide antipathogenic or antimicrobial surface properties for the external surfaces of the catheter used in combination, thereby extinguishing or inhibiting the growth of pathogens that communicate infectious agents to the underlying tissue, through contact with the respective outer surfaces.
    [0013] [013] In relation to the above description, before explaining at least one preferred embodiment of the invention disclosed in detail, it should be understood that the invention is not limited in its application to the details of construction and the disposition of components in the description below or as is illustrated in the drawings. The invention described here is capable of conceiving other modalities and of being practiced and carried out in various ways that will be obvious to those skilled in the art. Likewise, it should be understood that the phraseology and terminology used in this document are for the purpose of description and should not be considered as limiting.
    [0014] [014] As such, people skilled in the art will realize that the design on which this disclosure is based can readily be used as a basis for designing other structures, methods and systems to form an instrument to pass through the patient's skin to a position interior and project it from an incision in the skin, and for the realization of the various purposes of the present disclosed device. It is important, therefore, that the claims are considered to include such an equivalent construction and methodology, insofar as they do not depart from the spirit and scope of the present invention. SUMMARY OF THE INVENTION
    [0015] [015] The device disclosed and described herein provides a solution to the disadvantages in the prior art and achieves the goals noted above by providing an antimicrobial outer surface of catheter devices used to communicate through the skin and into the intended blood vessel or another target, where skin perforation is required. An antimicrobial surface area for a sufficient distance to communicate through the skin and above the outer surface of the patient's skin is formed on one or both distal ends of a catheter, such as a PICC. Thus, during any communication of the catheter device through the skin, and into the patient, bacteria, viruses and other infectious occupants from outside and any underlying layers of the skin will come in direct contact with the antimicrobial coating.
    [0016] [016] In addition, in other preferred modes, the catheter device may employ biocompatible surface coating together with the antimicrobial outer surface coating. By positioning a thin surface area of titanium on the circumferential outer surface of polyurethane and other catheters together with an antimicrobial coating, the device and method in the present invention provide a means for transforming conventional catheters into catheters with greater biocompatibility, as well as preventing the introduction of surface bacteria at the insertion site. In addition, a person skilled in the art will additionally find that such increased biocompatibility can, moreover, be accomplished by providing a titanium surface area on the inner surface and ends of the catheter, in combination with the outer surface layer noted above.
    [0017] [017] Titanium, in modern times, has been found in most human beings in order not to elicit, or minimally elicit the immune system's response. In addition, as a general rule, it has no toxic or harmful effect on the patient's body. Consequently, it is often used for implants, since it can be left in the body for long periods of time without causing discomfort, infection or irritation. As such, titanium has replaced stainless steel for long-term oral implants, and many joint and bone implants, where strength is a requirement and long-term body acceptance is critical. Such titanium implants are generally formed in a way to take advantage of the lightness of the material, but presenting great strength and resistance to bending and deterioration.
    [0018] [018] Antimicrobial material can be any material suitable for the intended purpose and with antimicrobial properties that can be employed. Particularly favored is one or a combination of materials in a coating that extends the distal end of the catheter, which is first introduced through the skin, up to a portion of the length of the catheter, as well as the proximal end of the catheter that remains protruding from the insertion site , up to a length that positions the coated surface above and below the skin layer, after being fully inserted. Such materials include one or a combination of antimicrobial materials from a group including silicon coated with nitrofurazone or silver, or silver ions or silver nanoparticles in a coating, or copper or copper-containing materials in a coating, hydroxyapatite coatings incorporated with chlorhexidine, coatings polylactide containing chlorhexidine on an anodized surface and polymer and calcium phosphate coatings with chlorhexidine, and aluminum and aluminum ions. However, in other preferred modes, the catheter can be impregnated or otherwise formed with antimicrobial materials and properties.
    [0019] [019] In relation to the above description, before explaining at least one preferred embodiment of the invention disclosed in detail, it should be understood that the invention is not limited in its application to the details of construction and the disposition of components in the description below or as is illustrated in the drawings. The invention described here is capable of conceiving other modalities and of being practiced and carried out in various ways that will be obvious to those skilled in the art. Likewise, it should be understood that the phraseology and terminology used in this document are for the purpose of description and should not be considered as limiting.
    [0020] [020] As such, people skilled in the art will realize that the design on which this disclosure is based can readily be used as a basis for designing other structures, methods and systems to form an instrument to pass through the patient's skin to a position interior and project it from an incision in the skin, and for the realization of the various purposes of the present disclosed device. It is important, therefore, that the claims are considered to include such an equivalent construction and methodology, insofar as they do not depart from the spirit and scope of the present invention.
    [0021] [021] As used in the claims to describe the various inventive aspects and modalities, "comprising" means "including, but not limited to" what follows the word "comprising". Thus, the use of the term "comprising" indicates that the elements listed are necessary or mandatory, but that other elements are optional and may or may not be present. By "consisting of" is meant to include, and is limited to, what follows the phrase "consisting of". Thus, the phrase "consisting of" indicates that the elements listed are necessary or mandatory, and that no other elements may be present. By "consisting essentially of" is meant to include any elements listed after the sentence, and limited to other elements that do not interfere with or contribute to the activity or action specified in the disclosure for the listed elements. Thus, the phrase "consisting essentially of" indicates that the elements listed are necessary or mandatory, but that other elements are optional and may or may not be present, depending on whether they affect the activity or action of the listed elements.
    [0022] [022] It is an object of the invention to provide a catheter device for connecting a distal end through a patient's skin layer to an internal target, where the proximal end remains protruding from the incision site, which has a portion of antimicrobial lining adjacent to one or both of the distal and proximal ends, such as PICC. BRIEF DESCRIPTION OF THE DRAWINGS FIGURES
    [0023] [023] Figure 1 shows a view of a catheter device with antimicrobial coatings in portions of one or both of the proximal and distal ends.
    [0024] [024] Figure 2 shows a perspective view of one end of the catheter device representing a multi-lumen catheter tube with antimicrobial coating over a distance from the end towards the center.
    [0025] [025] Figure 3 is a cross-sectional view of the device of Figure 2, showing a multiple lumen catheter with an outer antimicrobial coating, along the cut line AA of Figure 2.
    [0026] [026] Figure 4 is an otherwise preferential cross-sectional view of the device in Figure 1, showing a multiple lumen catheter with titanium and antimicrobial outer coatings.
    [0027] [027] Figure 5 shows a mode of the catheter fitted in the sterile package.
    [0028] [028] Figure 6 shows a different view of the device employing a spray bottle or other suitable medium for application, which allows the user to adapt existing catheters that may or may not have titanium surface layers, with an applied antimicrobial surface area. in an adhesive evaporative vehicle. DETAILED DESCRIPTION OF THE PREFERENTIAL MODALITIES OF THE INVENTION
    [0029] [029] Now referring to the drawings in figures 1 to 6, where similar components are identified by the same reference numbers, in figure 1 a view of the device 10 is observed providing a catheter 12 with titanium 17 or titanium combined with the surfaces coated antimicrobials 16 at one or both distal 20 and proximal 22 ends. In some ways, the entire outer surface may be of a titanium surface area 17, and in a minimal way, at least one and preferably both ends have an area surface of titanium 17 in a range 1 to 10 inches from the end towards a central portion of the catheter. In addition, it is noted that, in other modes of the invention, the entire length and surface area of the end walls 25 on the end walls of the catheter 12 may use an antimicrobial coating 16.
    [0030] [030] At the distal end 20, the sheath 16 may extend a distance D1 from the end-end wall 25 on the outer surface 14. Furthermore, at the proximal end 22, the sheath 16 may extend, from the wall of the opposite end-end 25 , a distance D2 on the outer surface 14. As noted earlier, the distal end 20 is inserted through the skin barrier and is a potential vehicle for infectious agents, while the proximal end 22 will remain protruding from the insertion site and the skin barrier. , as necessary for the operative connection of other instruments for the introduction of fluid drainage. Thus, it should be understood that the distances D1 and D2, which use such a coating 16, can vary in length as necessary, for the intended purposes of the device. People skilled in the art can immediately find suitable lengths for that distance, and are anticipated.
    [0031] [031] In addition, catheter 12 has an intermediate portion "I" extending from the lining area 16 of the proximal end 22 to the lining area 16 of the distal end 20. That intermediate portion I may or may not include the material of coating 16 in its application, as disclosed with the functional use of that invention.
    [0032] [032] The device disclosed in the present invention can be formed from conventional materials, such as polyurethane, silicone or polytetrafluoroethylene ("PTFE"). However, it can also be formed from any material suitable for use together with the disclosed coating of an antimicrobial material, for the purposes set out in the present disclosure. Again, it should be noted that the body 20 may, alternatively, be partially or totally formed of an antimicrobial impregnated material in a solid solution, or any other means that gives it antimicrobial properties therein to communicate with the circumferential surface.
    [0033] [033] It should be noted that the antimicrobial coating can be applied by any conventional means known in the art, such as vacuum chamber coating, plasma coating, use of an antimicrobial material in an impregnated polymer or other vehicle used as coatings, or impregnating the proximal and distal ends of the catheter itself, or other means that could occur for people skilled in the art. Although titanium is an antimicrobial material particularly favored in the present invention, due to the fact that experimentation demonstrates that it encourages the attraction of a fluid coating to the circumferential surface, and therefore, it is verified that it is a means to encourage the lubricity of the exterior of the catheter to prevent tissue adhesion, antimicrobial materials could also include one or a combination of antimicrobial materials from a group including silicon coated with nitrofurazone, silver, silver ions or silver nanoparticles, copper or copper-containing materials in a coating, or impregnated in the material that forms the catheter, or retracted. Other antimicrobial materials can also be placed adjacent to titanium, such as one or a combination of hydroxyapatite coatings incorporated with chlorhexidine, polylactide coatings containing chlorhexidine on an anodized surface and polymer and calcium phosphate coatings with chlorhexidine, in a coating or mixed in a polymeric coating.
    [0034] [034] It may be an advantage of the present invention to provide an antimicrobial coated surface area 16 of the distal end 20 of the catheter 12 using only titanium, or containing titanium in combination with the other antimicrobials cited in the present invention, in order to reduce or eliminate contamination by pathogens at the insertion site during the catheter's operative insertion 12. Such a reduction could continue during the period that the catheter remains implanted in the patient, and the titanium surface area will provide improved lubricity to prevent tissue adherence to it.
    [0035] [035] In addition and preferably, the first end or the proximal end 22 is coated with antimicrobial, since it protrudes from the insertion site that communicates through the patient's skin, once the insertion procedure is completed. The placement of the lining on the proximal end, which communicates through the skin's surface, will inhibit the pathogen's displacement along the catheter's surface and below the patient's skin surface, which is the first barrier to such invasions.
    [0036] [036] Furthermore, in other modes, the total length of the outer surface 14 of the catheter 12 may additionally employ antimicrobial materials therein, individually or in combination, or may have only one titanium surface, since it provides a means for encourage lubricity. Alternatively, the titanium surface area, across the circumferential surface, can be used in combination with one or a combination of other antimicrobials mentioned in the present invention.
    [0037] [037] Figure 2 shows the coating as it would be for a distance at one or both proximal and distal ends of the catheter, in the preferred mode of the device. In the elevated and cross-sectional views of figure 2 and figure 3, respectively, the device 10 comprising a catheter 12 with a surface area of antimicrobial material 16 on it, which is coated, adhered, impregnated or otherwise Thus, formed thereon in order to communicate directly with the outer surface area 14 of the catheter 12 at one or both ends. Catheter 12 can be polyurethane or silicone, polyethylene or any other material known in the art for catheters and similar tubes, suitable for receiving an antimicrobial coating at one or both ends.
    [0038] [038] Additionally, an area or surface portion of titanium can preferably be included in combination with one or more of the other antimicrobial materials mentioned on one or both ends, and is particularly favored with the action of pathogens and improved lubricity, and within the scope of the device 10. The titanium surface area or surface portion may be combined with one or a combination of the other antimicrobial materials in the group thereof, including chlorhexidine-incorporated hydroxyapatite coatings, polylactide coatings containing chlorhexidine on an anodized surface and polymer and calcium phosphate coatings with chlorhexidine. This allows the titanium outer surface area to provide a means to inhibit a rejection reaction by protective actions of the body, such as leukocyte attacks, to make the catheter placement long-term or even short-term for such purposes. procedures such as a PICC line, easier on the patient's body. In addition, the titanium thus placed, in addition to increasing lubricity, has antimicrobial and antipathogenic properties.
    [0039] [039] Although shown as a double lumen catheter, persons skilled in the art will understand that the catheters have several internal lumens, from one to several lumens, and the double lumen catheter 12 depicted is for illustrative purposes only, since the present invention is applicable to all catheters and tubes that can be used in medical uses for insertion into a patient.
    [0040] [040] Figure 4 shows an otherwise particularly preferential cross section of the device 10 which uses a titanium and antimicrobial coating. The titanium surface area or coating may occur over the entire outer and / or inner surface, and the other antimicrobial and antipathogenic coating materials may be present at one or both ends of the catheter, and be one or a combination of the group noted above.
    [0041] [041] It is preferable that catheter 12 maintains its flexibility as needed for intravenous insertion, and this is provided as the surface area of titanium 17 is substantially thin and since titanium, by nature, is more flexible than than other metals. In a particularly preferred mode, the titanium surface area 17 on the outer surface 14 of catheter 12 is of the order of magnitude equal to or less than 2 microns. Thus, catheter 12 makes use of the benefits of antimicrobial properties, as well as biocompatibility and other benefits associated with the antimicrobial surface area 16 and the titanium surface area 17, without compromising the flexibility of the structure necessary to advance the device 10 through the blood vessels commonly shaped like a serpentine, to place the distal end in the desired location. In addition, when moistened, the titanium surface provides a means to improve lubricity and overcome tissue friction against the outside of catheter 12, and to prevent tissue attachment to the outside of catheter 12 during longer periods of time. insertion, as with a PICC line.
    [0042] [042] The surface area of titanium 17 is preferably formed by conventional methods, such as coating, spraying, thermoforming, film bonding or extrusion of the catheter using a mixture of polymeric material and titanium oxide in a mixture, or by shrinking or forming the vacuum a titanium sleeve over it, or other means known in the art. In addition, it should be noted that, in order to adhere or otherwise form the titanium surface area 17 on some types of catheters 12, those skilled in the art may use several other titanium alloys more suitable for different types of piping, and this is provided for in the scope of this patent.
    [0043] [043] Figure 5 shows a mode of the device 10 with the catheter 12 attached inside the sterile package 26, as is common in the art. Package 26 may have a detachable corner, allowing the user to open package 26 and pick up catheter 12.
    [0044] [044] Figure 6 shows another mode of the disclosed device 10 providing the user with a means to adapt existing unprotected catheters 12 with an antimicrobial coating. This is currently provided by a spray bottle 28 or other container to discharge a mixture of a curing vehicle, such as polyethylene or other polymeric material, which will cure when exposed to air or with the addition of a curing agent. The antimicrobial material 30 is mixed to dispense with the polymer or other curing vehicle, in a spray, flow, atomized spray or similar, with the purpose of the user applying an area covered with a solid cured solution of polymeric material and antimicrobial agent, such as silver nitrate, which will transfer silver ions to the coating of the antimicrobial surface 16 formed by the dispensed mixture 30 on the desired unprotected surfaces of catheter 12. However, it is observed that other modes are envisioned, in which the antimicrobial material is provided as a liquid, gas, ointment, balm or similar, which allows the user to apply a coating on the desired instrument.
    [0045] [045] It should be noted that it is within the scope of the invention that the wall surfaces of the end end 25 of the proximal end 20 and the distal end 22 additionally use antimicrobial 16 and titanium 17 coatings in the same way. Although all the fundamental characteristics and aspects of the invention have been presented and described in the present invention, with reference to the particular modalities of the same, a variety of modifications, various changes and substitutions are intended in the above disclosure and it will be evident that, in some cases, some features of the invention can be employed without the corresponding use of other features, without departing from the scope of the invention as defined. It should also be understood that various substitutions, modifications and variations can be made by persons skilled in the art without departing from the spirit or scope of the invention. Consequently, all such modifications and variations and substitutions are included in the scope of the invention, as defined by the following claims.
    权利要求:
    Claims (4)
    [0001]
    Catheter with antimicrobial coating (12) comprising: at least one inner lumen defined by a side wall having a circumferential outer surface that extends between a first end (22) of said catheter and a second end (20) of said catheter; and a titanium surface area (14) that communicates along said circumferential surface, CHARACTERIZED by the fact that said titanium surface covering the entire said circumferential surface and defining a means to inhibit pathogens and a means to improve lubricity with the fabric in contact with said circumferential surface, thus providing the prevention of adherence of the fabric to it, and an antipathogenic and / or antimicrobial surface area positioned adjacent to said titanium surface area on said circumferential surface.
    [0002]
    Catheter, according to claim 1, CHARACTERIZED by the fact that said antipathogenic and / or antimicrobial surface area is in one or both of said first and said second ends.
    [0003]
    Catheter according to claim 1 or 2, CHARACTERIZED by the fact that said titanium surface area extends a distance towards a central portion of said catheter, of one or both of said first end and said second end .
    [0004]
    Catheter, according to any one of claims 1 to 3, CHARACTERIZED by the fact that the titanium surface area extends within said lumen and / or at its ends.
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    法律状态:
    2018-12-04| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-06-18| B25G| Requested change of headquarter approved|Owner name: PFM MEDICAL, INC. (US) |
    2019-10-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-01-26| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-03-23| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/03/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201261610344P| true| 2012-03-13|2012-03-13|
    US61/610,344|2012-03-13|
    PCT/US2013/031095|WO2013138534A1|2012-03-13|2013-03-13|Catheter having antimicrobial coating|
    US13/802,387|US20130245568A1|2012-03-13|2013-03-13|Catheter having antimicrobial coating|
    US13/802,387|2013-03-13|
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