 ARILALKYLOXYPYRIMIDINE DERIVATIVE, PESTICIDE FOR AGRICULTURAL AND HORTICOLAL USE CONTAINING THE ARIL
专利摘要:
Patent Summary: "Arylalkyloxypyrimidine derivative, pesticide for agricultural and horticultural use containing arylalkyloxypyrimidine derivative as an active ingredient and use thereof". The present invention relates to an arylalkyloxypyrimidine derivative represented by the formula (I) wherein R1 is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a haloalkyl group, a alkoxyalkyl group, a dioxolane group and the like; R 2 and R 3 are each a hydrogen atom, an alkyl group and the like; x is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a haloalkenyl group, a haloalkylyl group, a trialkylsilyl group and the like; y is ch or a nitrogen atom; q is an integer from 1 to 3; m is an integer from 0 to 5; and n is 0 or 1 or a salt thereof and an agricultural insecticide containing the compound as an active ingredient and a method of use thereof. 公开号:BR112014019099B1 申请号:R112014019099-2 申请日:2013-02-01 公开日:2019-04-02 发明作者:Eikou Satoh；Tetsuya Murata；Hiroto Harayama；Motofumi Nakano；Kosuke Fukatsu；Kayo Inukai；Ryota Kasahara；Yutaka Abe；Nobuyuki Hayashi；Naoya Fujita 申请人:Nihon Nohyaku Co., Ltd.； IPC主号:
专利说明:
Descriptive Report of the Invention Patent for ARYLALKYLOXYPYRIMIDINE DERIVATIVE, PESTICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING THE ARYLALKYL OXYPYRIMIDINE DERIVATIVE AS AN ACTIVE INGREDIENT AND USE OF THE SAME. TECHNICAL FIELD OF THE INVENTION [0001] The present invention relates to an agricultural insecticide containing an arylalkyloxypyrimidine derivative or a salt thereof as an active ingredient and a method of using the same. BACKGROUND OF THE INVENTION [0002] Patent Document 1 suggests that a derivative in which position 4 of the pyrimidine ring is replaced by an arylalkyloxy has an antifungal or insecticidal activity. In addition, Patent Document 2 describes that certain types of pyrimidine derivatives are useful as a pharmaceutical product. However, it does not contain a description of an insecticidal activity. Documents list Patent Documents [0003] Patent Document 1: JP-A-08-283246 [0004] Patent Document 2: WO1996 / 011902 SUMMARY OF THE INVENTION Problems to be solved by the invention [0005] In crop production in agricultural and horticultural fields, the damage caused by insect pests is still serious and the development of new agricultural insecticides and acaricides is desired due to the generation of agent-resistant insect pests known and the like. Since it is necessary to save farmers' labor due to the growing number of the aging agricultural population, the creation of agricultural insecticides and mites having properties suitable for farmers is also required. 2/150 Means to Solve the Problems [0006] The present inventors conducted intensive studies in an attempt to develop a new agricultural insecticide and found that the arylalkyloxypyrimidine derivative or a salt thereof represented by the formula (I) of the present invention is useful as an agricultural insecticide , which resulted in completion of the present invention. [0007] Consequently, the present invention relates to [1] An arylalkyloxypyrimidine derivative represented by formula (I): R 3 R 1 L ^ T ( X ) m (I) where R 1 is (a1) a halogen atom; (a2) a formyl group; (a3) a cyan group; (a4) a (C 1 -C 8 ) alkyl group; (a5) a (C 3 -C 8 ) cycloalkyl group; (a6) an (C2-C8) alkenyl group; (a7) an (C2-C8) alkynyl group; (a8) a halo (C 1 -C 8 ) alkyl group; (a9) a halo (C 3 -C 8 ) cycloalkyl group; (a10) a halo (C 2 -C 8 ) alkenyl group; (a11) a halo (C2-C8) alkynyl group; (a12) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (a13) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (a14) a (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkyl; (a15) a (C 3 -C 8 ) cycloalkyl-halo (C 1 -C 8 ) alkyl group; 3/150 (a16) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; (a17) a (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkyl group; (a18) a (C 1 -C 8 ) alkyl sulfonyl (C 1 -C 8 ) alkyl group; (a19) a halo (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (a20) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (a21) a halo (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; (a22) a halo (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkyl group; (a23) a halo (C 1 -C 8 ) alkylsulfonyl (C 1 -C 8 ) alkyl group; (a24) a halo (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkyl group; (a25) a cyano (C1-C8) alkyl group; (a26) a nitro (C 1 -C 8 ) alkyl group; (a27) an R 4 (R 5 ) N (C1-C8) alkyl group in which R 4 and R 5 can be the same or different and each is (i) a hydrogen atom, (ii) a (C1) group -C 6 ) alkyl, (iii) a (C 3 -C 6 ) cycloalkyl group, (iv) a (C2-C6) alkenyl group, (v) a (C2-C6) alkynyl group, (vi) a group ( C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkyl, (vii) a halo (C 1 -C 6 ) alkyl group, (viii) a halo (C 3 -C 6 ) cycloalkyl group, (ix) a halo (C 2 -C 6 ) alkenyl group, (x) a halo (C2-C6) alkynyl group, (xi) a halo (C3-C6) cycloalkyl (C 1 -C 6 ) alkyl group, (xii) a group (C 1 -C 6 ) alkyl sulfonyl, (xiii) a (C 1 -C 6 ) alkylcarbonyl group, (xiv) a halo (C 1 -C 6 ) alkylcarbonyl group, (xv) a (C 1 -C 6 ) alkoxycarbonyl, (xvi) a (C 3 -C 6 ) cycloalkylcarbonyl group, (xvii) a phenyl group, (xviii) a phenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C 1 -C 6 ) alkyl group, (c) a halo (C 1 -C 6 ) alkyl group, (d ) a (C 1 -C 6 ) alkoxy group, (e) a halo (C 1 C6) alkoxy group and (f) a phenoxy group, (xix) a phenoxyphenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C 1 -C 6 ) alkyl group, (c) a halo (C 1 -C 6 ) alkyl group, (d) a (C 1 - C 6 ) alkoxy and (e) a halo group (C 1 C 6 ) alkoxy, (xx) a hydroxy group (C 1 -C 8 ) alkyl, (xxi) a phenyl group (C 1 4/150 C 6 ) alkyl, (xxii) a phenyl group (C 1 -C 6 ) alkyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a group (C 1- C 6 ) alkyl, (c) a halo (C 1 C 6 ) alkyl group, (d) a (C 1 -C 6 ) alkoxy group, (e) a halo (C 1 -C 6 ) alkoxy group and (f) a phenoxy group or (xxiii) a phenoxyphenyl (C 1 -C 6 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a group (C 1 -C 6 ) alkyl, (c) a halo (C 1 -C 6 ) alkyl group, (d) a (C 1 -C 6 ) alkoxy group and (e) a halo group (C 1 -C 6 ) alkoxy; (a28) an (R 4 ) OC (C 1 -C 8 ) alkyl group where R 4 is as defined above; (a29) an (R 4 ) O 2 C (C 1 -C 8 ) alkyl group where R 4 is as defined above; (a30) an R 4 (R 5 ) NCO (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a31) an aryl group; (a32) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C 1 -C 6 ) alkylthio, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo group (C 1 -C 6 ) alkyl sulfonyl, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above and (t) a phenoxy group; (a33) an aryl (C 1 -C 8 ) alkyl group; (a34) an aryl (C 1 -C 8 ) alkyl group having, on the ring, the 5/150 same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a group (C 1 - C 6 ) alkyl, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C1-C6) alkoxy group, (h) a halo (C1-C6) alkoxy group, (i) a group (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo (C 1 -C 6 ) alkylthio group, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a group halo (C 1 -C 6 ) alkylsulfonyl, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a35) an arylcarbonyl group; (a36) an arylcarbonyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C 1 -C 6 ) alkylthio, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo group (C 1 -C 6 ) alkyl sulfonyl, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a37) an arylthio (C 1 -C 8 ) alkyl group; (a38) an arylthio group (C 1 -C 8 ) alkyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 group) ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a 6/150 (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a (C 1 -C 6 ) alkylsulfonyl group, ( p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a39) an arylsulfinyl (C 1 -C 8 ) alkyl group; (a40) an arylsulfinyl (C 1 -C 8 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C 6 ) alkyl group, (g) a (C 1 -C 6 group) ) alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C) group 6 ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a41) an arylsulfonyl (C 1 -C 8 ) alkyl group; (a42) an arylsulfonyl (C 1 -C 8 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C) group 6 ) alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 - C 6 ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 8 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkyl group -sulfinyl, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 C6) alkylcarbonyl group, (q) a carboxyl group, (r) an (C1C6) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 7/150 are as defined above; (a43) a (C 1 -C 8 ) alkylcarbonyl group; (a44) a (C 3 -C 8 ) cycloalkylcarbonyl group; (a45) an (C 1 -C 8 ) alkoxycarbonyl group; (a46) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a47) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl; (a48) a (C 1 -C 8 ) alkoxycarbonyl (C 1 -C 8 ) alkyl group; (a49) a heterocyclic group; (a50) a heterocyclic group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C 1 -C 6 ) alkylthio, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo group (C 1 -C 6 ) alkyl sulfonyl, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) a phenyl group, (u) an oxo group and ( v) a (C 1 -C 6 ) alkoxycarbonyl (C 1 -C 6 ) alkyl group; (a51) a heterocyclyl (C 1 -C 8 ) alkyl group; (a52) a heterocyclyl (C 1 -C 8 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C 6 ) alkyl group, (g) an (C 1 -C 6 ) alkoxy group , (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 8 ) alkoxy group, (j) a (C 1 -C 6 ) group alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkyl8 / 150 sulfinyl group, (m) a halo (C 1 -C 6 ) alkyl sulfinyl group , (n) a (C 1 C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) an oxo group; (a53) a heterocyclyl (C 3 -C 8 ) cycloalkyl group; (a54) a heterocyclyl (C3-C8) cycloalkyl group having, on the heterocycle, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, ( h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 C 6 ) alkylthio group, ( k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above and (t) an oxo group; (a55) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a56) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (a57) an oxiranyl group; (a58) a tetrahydropyranyloxy (C1-C8) alkyl group; (a59) a tetrahydrofuranyloxy (C 1 -C 8 ) alkyl group; (a60) a tetrahydropyranylcarbonyl group; (a61) a formyloxy (C 1 -C 8 ) alkyl group; (a62) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkylcarbonyl group; (a63) a heterocyclylcarbonyl group; 9/150 (a64) a heterocyclylcarbonyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) an (C1-C6) alkoxy group, (h) a group halo (C1-C6) alkoxy, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C 1 -C 6 ) alkylthio, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo (C 1 -C 6 ) alkyl sulfonyl group, (p) a (C 1 C6) alkylcarbonyl group, (q) a carboxyl group, (r) a group ( C1-C6) alkoxycarbonyl, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) an oxo group; (a65) a hydroxy (C 1 -C 8 ) alkyl group; (a66) an aryloxy (C 1 -C 8 ) alkyl group; (a67) an aryloxy group (C 1 -C 8 ) alkyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 group) ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group , (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 C6) alkylcarbonyl group, (q) a carboxyl group, (r) an (C1-C6) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above; (a68) a (C1-C8) alkylthio (C1-C8) alkoxy (C1-C8) alkyl group; (a69) a (C1-C8) alkylsulfinyl (C1-C8) alkoxy (C1-C8) alkyl group; (a70) a ((C1-C8) alkoxy) group ((C3-C8) cycloalkyl) (C1-C8) from 10/150 kyl; (a71) an R 4 CO (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a72) an R 4 CO2 (R 5 ) N (C 1 -C 8 ) alkyl group where R 4 and R 5 are as defined above; (a73) an R 4 SO2 (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a74) an R 4 (R 5 ) NCO 2 (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a75) a (R 4 (R 5 ) N) ((C 3 -C 8 ) cycloalkyl) (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a76) an ((C 1 -C 8 ) alkylthio) ((C 3 -C 8 ) cycloalkyl) (C 1 -C 8 ) alkyl group; (a77) an ((C1-C8) alkylsulfinyl) ((C3-C8) cycloalkyl) (C1C8) alkyl group; (a78) an ((C1-C8) alkylsulfonyl) ((C3-C8) cycloalkyl) (C1C8) alkyl group; (a79) a (heterocyclyl) ((C 3 -C 8 ) cycloalkyl) (C 1 -C 8 ) alkyl group; (a80) a (heterocyclyl) ((C3-C8) cycloalkyl) (C1-C8) alkyl group having, on the hetero ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C1-C6) alkyl group, (f) a halo (C1-C6) alkyl group, (g) a (C1) group -C6) alkoxy, (h) a halo (C1-C6) alkoxy group, (i) a (C3-C6) cycloalkyl (C1-C6) alkoxy group, (j) a (C1-C6) alkylthio group, (k ) a halo (C1-C6) alkylthio group, (l) a (C1-C6) alkylsulfinyl group, (m) a halo (C1-C6) alkylsulfinyl group, (n) a (C1-C6) group alkylsulfonyl, (o) a halo (C1-C6) alkylsulfonyl group, (p) a (C1-C6) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) group alkoxycarbonyl, (s) an R 4 (R 5 ) N carbonyl group / 150 la where R 4 and R 5 are as defined above and (t) an oxo group; (a81) a (heterocyclyl) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a82) a (heterocyclyl) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group having, on the hetero ring, the same or different 1 to 5 substituents selected from (a) a halogen atom , (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group , (g) a (C 1 -C 6 ) alkoxy group, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) group alkoxy, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C1-C6) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) an oxo group; (a83) a di (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxy group can be the same or different; (a84) a di (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group in which the alkyls of the di (C 1 -C 8 ) alkylthio group can be the same or different; (a85) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a86) a carboxyl group; (a87) an aryloxycarbonyl group; (a88) a group C (R 4 ) = NOSO 2 R 5 where R 4 and R 5 are as defined above; (a89) a heterocyclylimino (C 1 -C 8 ) alkyl group; (a90) a tri (C 1 -C 8 ) alkyl silyl (C 2 -C 8 ) alkynyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; 12/150 (a91) a (C 1 -C 8 ) alkoxy (C 2 -C 8 ) alkynyl group; (a92) a hydroxy group (C 2 -C 8 ) alkynyl; (a93) a (hydroxy) ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a94) a dihydroxy (C 1 -C 8 ) alkyl group; (a95) a (hydroxy) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a96) a di (C 1 -C 8 ) alkylsulfonyloxy (C 1 -C 8 ) alkyl group wherein the alkyls of the di (C 1 -C 8 ) alkylsulfonyloxy group can be the same or different; (a97) a di ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group in which the alkoxys of the di ((C 1 -C 8 ) alkoxy (C 1- C 8 ) alkoxy can be the same or different; (a98) a di (C 1 -C 8 ) alkoxycarbonyl (C 2 -C 8 ) alkenyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxycarbonyl group can be the same or different; (a99) an (C 1 -C 8 ) alkoxycarbonyl (cyano) (C 2 -C 8 ) alkenyl group; (a100) an ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (hydroxy) (C 1 -C 8 ) alkyl group; (a101) an alkenyl dichian (C2-C8) group; (a102) a (C3-C8) cycloalkylidene (C1-C8) alkyl group; (a103) a (C3-C8) cycloalkyl (hydroxy) (C1-C8) alkyl group; (a104) a (C3-C8) cycloalkyl ((C1-C8) alkoxy) (C1-C8) alkyl group; (a105) a heterocyclyl (C2-C8) alkenyl group; (a106) a heterocyclyl (C2-C8) alkenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) an (C 1 -C 6 ) alkoxy group, (h) a halo (C 1 -C 6 ) alkoxy group, (i) 13/150 a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo (C 1 -C 6 ) alkylthio group , (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o ) a halo (C 1 -C 6 ) alkyl sulfonyl group, (p) a (C 1 C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 C 6 ) alkoxycarbonyl group, (s ) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) an oxo group; (a107) a halo (C 1 -C 8 ) alkylcarbonyloxy (C 2 -C 8 ) alkenyl group; (a108) a (C3-C8) cycloalkyl (halo (C1-C8) alkylcarbonyloxy) (C1-C8) alkyl group; (a109) an (C 1 -C 8 ) alkoxycarbonyl (hydroxy) (C 1 -C 8 ) alkyl group; (a110) a carboxy (hydroxy) (C1-C8) alkyl group; (a111) a di (C1-C8) alkoxycarbonyl (C3-C8) cycloalkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; (a112) a di (C1-C8) alkoxycarbonyl (C1-C8) alkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; (a113) a (C1-C8) alkylcarbonyl (C2-C8) alkenyl group; (a114) a hydroxy-halo (C1-C8) alkyl group; (a115) a dihydroxy halo (C1-C8) alkyl group; (a116) a (C1-C8) alkoxycarbonyl (C3-C8) cycloalkyl group; (a117) a cyano (C3-C8) cycloalkyl group; (a118) an (C1-C8) alkoxycarbonyl (C2-C8) alkenyl group; (a119) a cyano (C2-C8) alkenyl group; (a120) a ((C1-C8) alkoxy) (hydroxy) halo (C1-C8) alkyl group; (a121) an R 4 (R 5 ) N (C 1 -C 8) alkyl (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above; 14/150 (a122) an R 4 (R 5 ) NCO (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a123) a tri (C1-C8) alkyl silyl (C2-C8) alkynyl (C2-C8) alkenyl group in which the alkyls of the tri (C1-C8) alkyl silyl group can be the same or different; or (a124) the following structural formula Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , 10 , Q 11 , Q 12 , Q 13 , Q 14 , Q 15 , Q 16 , Q 17 , Q 18 , Q 19 , Q 20 , Q 21 , Q 22 , 26 , Q 27 , Q 28 or Q 29 R , R, P R () R) p R,. R () R ) P Q 7 , Q 8 , Q 9 , Q Q 23 , Q 24 , Q 25 , Q R 6 /> ^ O (r7) p Q 1 Q 2 Q 3 Q 4 Q 5 Q 6 Q 8 R 6 /.'x À2> 7) P Q 9 . SA: 1 'rz'a / Z 2> 7) P (R 7 ) p Q 13 Q 7 R6 zí > X ^ - ( R7 ) p Q 11 Q 12 Q 10 Q 14 R ' Z z .. ^ r7 ' f Zr) R 6 ZA Z ^ ’ Q 15 Q 16 Q 17 Q 18 Q 19 Zf • S. J- (R 7 ) P N Ra ^ - ^ p rix R 6 '<( Q 20 Q 21 Q 22 Q 23 Q 24R 6 zCa R 6 ZA z 2 ^ 3 RK1B R 6 ZS • (R 7 ) p Q 25 Q 26 Q 27 Q 28 Q 29 where R 6 , R 7 and R 8 can be ; r the same: s or diferent es and each one is a hydrogen atom, a (C 1 -C 6 ) alkyl group, a (C 3 -C 6 ) cycloalkyl group, a (C2-C6) alkenyl group, a (C2-C6) alkynyl group, a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkyl, a halo (C 1 -C 6 ) alkyl group, a 15/150 halo (C3-C 6 ) cycloalkyl group, halo (C 2 -C 6 ) alkenyl group, halo (C 2 -C 6 ) alkynyl group, halo (C 3 -C 6 ) cycloalkyl group (C 1- C 6 ) alkyl, a (C 1 -C 6 ) alkylcarbonyloxy (C 1 -C 6 ) alkyl group, a (C 1 -C 6 ) alkoxy (C 1 -C 6 ) alkyl group, a hydroxy group (C 1 -C 6 ) alkyl, a (C 2 -C 6 ) alkenyloxy (C 1 -C 6 ) alkyl, a phenoxy (C 1 -C 6 ) alkyl group, a (C 1 -C 6 ) alkylsulfonyl group (C 1 -C 6 ) alkyl, a (C 1 -C 6 ) alkyl sulfonyloxy (C 1 -C 6 ) alkyl, a halogen atom, a phenyl group, a phenyl (C 1 -C 6 ) alkyl group or a (C 1 -C 6 ) alkylcarbonyl group, R 9 is a cyano group, a halo (C 1 -C 6 ) alkyl group or a halo (C 1 -C 6 ) alkylcarbonyl group, p is an integer from 0 to 5 and Z 1 and Z 2 can be the same or different and each is a carbon atom, an oxygen atom, S, SO, SO 2 or NR 6 where R 6 is as defined above or, when p is 2, the two adjacent R 7 can be linked to form an aliphatic ring of 3 to 8 elements; R 2 and R 3 can be the same or different and each is (b1) a hydrogen atom; (b2) a (C 1 -C 8 ) alkyl group; (b3) a (C3-C8) cycloalkyl group; (b4) an (C 2 -C 8 ) alkenyl group; (b5) an (C2-C8) alkynyl group; (b6) a halo (C 1 -C 8 ) alkyl group; (b7) a halo (C3-C8) cycloalkyl group; (b8) a halo (C2-C8) alkenyl group; (b9) a halo (C2-C8) alkynyl group; (b10) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (b11) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (b12) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; or (b13) an (C 1 -C 8 ) alkoxycarbonyl group, q is an integer from 1 to 3; 16/150 X can be the same or different and each is (c1) a hydrogen atom; (c2) a halogen atom; (c3) a hydroxyl group; (c4) a cyano group; (c5) a nitro group; (c6) an N (R 4 ) (R 5 ) group in which R 4 and R 5 are as defined above; (c7) an N (R 4 ) CO (R 5 ) group in which R 4 and R 5 are as defined above; (c8) an N (R 4 ) SO 2 (R 5 ) group in which R 4 and R 5 are as defined above; (c9) an N (R 4 ) CO 2 (R 5 ) group in which R 4 and R 5 are as defined above; (c10) a CO group (R 4 ) where R 4 is as defined above; (c11) a CO 2 group (R 4 ) where R 4 is as defined above; (c12) a CON (R 4 ) (R 5 ) group in which R 4 and R 5 are as defined above; (c13) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c14) an (C1-C8) alkyl group; (c15) an (C2-C8) alkenyl group; (c16) an (C2-C8) alkynyl group; (c17) a (C3-C8) cycloalkyl group; (c18) a halo (C1-C8) alkyl group; (c19) a halo (C2-C8) alkenyl group; (c20) a halo (C2-C8) alkynyl group; (c21) a halo (C3-C8) cycloalkyl group; 17/150 (c22) a tri (C 1 -C 8 ) alkyl silyl group in which the alkyls can be the same or different; (c23) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (c24) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (c25) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (c26) a (C 3 -C 8 ) cycloalkyl (C 3 -C 8 ) cycloalkyl group; (c27) an (C 1 -C 8 ) alkoxy group; (c28) an (C2-C8) alkenyloxy group; (c29) an (C 2 -C 8 ) alkynyloxy group; (c30) a (C 3 -C 8 ) cycloalkyloxy group (said cycloalkyl is optionally fused with a benzene ring); (c31) a halo (C 1 -C 8 ) alkoxy group; (c32) a halo (C2-C8) alkenyloxy group; (c33) a halo (C2-C8) alkynyloxy group; (c34) a halo (C3-C8) cycloalkyloxy group (said cycloalkyl is optionally fused with a benzene ring); (c35) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkoxy group; (c36) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkoxy group; (c37) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (c38) a halo (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy group; (c39) a (C 1 -C 8 ) alkoxy halo (C 1 -C 8 ) alkoxy; (c40) a halo (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkoxy; (c41) a mercapto group; (c42) an (C 1 -C 8 ) alkylthio group; (c43) an (C2-C8) alkenylthio group; (c44) an (C2-C8) alkynylthio group; (c45) a (C3-C8) cycloalkylthio group; (c46) a halo (C 1 -C 8 ) alkylthio group; 18/150 (c47) a halo (C 2 -C 8 ) alkenylthio group; (c48) a halo (C 2 -C 8 ) alkynylthio group; (c49) a halo (C 3 -C 8 ) cycloalkylthio group; (c50) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylthio group; (c51) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylthio group; (c52) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkylthio group; (c53) a halo (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkylthio group; (c54) a (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkylthio; (c55) a halo (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkylthio; (c56) a (C 1 -C 8 ) alkylsulfinyl group; (c57) a (C 2 -C 8 ) alkenyl sulfinyl group; (c58) an (C 2 -C 8 ) alkynylsulfinyl group; (c59) a (C 3 -C 8 ) cycloalkylsulfinyl group; (c60) a halo (C 1 -C 8 ) alkylsulfinyl group; (c61) a halo (C 2 -C 8 ) alkenyl sulfinyl group; (c62) a halo (C 2 -C 8 ) alkynylsulfinyl group; (c63) a halo (C 3 -C 8 ) cycloalkylsulfinyl group; (c64) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylsulfinyl group; (c65) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylsulfinyl group; (c66) a (C 1 -C 8 ) alkyl sulfonyl group; (c67) a (C 2 -C 8 ) alkenyl sulfonyl group; (c68) an (C 2 -C 8 ) alkynyl sulfonyl group; (c69) a (C 3 -C 8 ) cycloalkyl sulfonyl group; (c70) a halo (C 1 -C 8 ) alkyl sulfonyl group; (c71) a halo (C 2 -C 8 ) alkenyl sulfonyl group; (c72) a halo (C 2 -C 8 ) alkynyl sulfonyl group; (c73) a halo (C 3 -C 8 ) cycloalkyl sulfonyl group; (c74) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylsulfonyl group; (c75) a halo (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkylsulfonyl group; (c76) an aryl group; 19/150 (c77) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a (C1C 6 ) alkyl group, (e) a (C 1 -C 6 ) halo alkyl group, (f) a (C 1 -C 6 ) alkoxy group, (g) a halo (C 1 -C 6 ) group alkoxy, (h) an (C 2 -C 6 ) alkenyloxy group, (i) a halo (C 2 -C 6 ) alkenyloxy group, (j) an (C 2 -C 6 ) alkynyloxy group, (k) a group halo (C 2 -C 6 ) alkynyloxy, (l) a (C 3 -C 6 ) cycloalkoxy group, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1C) group 6 ) alkoxy, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy, (p) a (C 1 -C 6 ) alkylthio group, (q) a halo (C 1 ) group -C 6 ) alkylthio, (r) a (C 1 C 6 ) alkylsulfinyl group, (s) a halo (C 1 -C 6 ) alkylsulfinyl group, (t) a (C 1 -C 6 ) group alkylsulfonyl, (u) a halo (C 1 -C 6 ) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w) a group N (R 4 ) CO R 5 where R 4 and R 5 are as defined above, (x) a group N (R 4 ) CO 2 R 5 where R 4 and R 5 are as defined above, (y) a group N (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a CO2R 4 group where R 4 is as defined above, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c78) an aryl (C 1 -C 8 ) alkyl group; (c79) an aryl (C 1 -C 6 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a (C 1 -C 6 ) alkyl group, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 C 6 ) alkoxy group, (g) a halo group (C 1 -C 6 ) alkoxy, (h) a (C 2 C6) alkenyloxy group, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2C6) alkynyloxy group, (k) a halo group (C2-C6) alkynyloxy, (l) a (C3C6) cycloalkoxy group, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3C6) cycloalkyl (C1-C6) alkoxy group, (o) an halo group (C3-C6) cycloalkyl (C1 20/150 C 6 ) alkoxy, (p) a (C 1 -C 6 ) alkylthio group, (q) a halo (C 1 C 6 ) alkylthio group, (r) a (C 1 -C 6 ) alkylsulfinyl group, ( s) a halo (C 1 C 6 ) alkylsulfinyl group, (t) a (C 1 -C 6 ) alkylsulfonyl group, (u) a halo (C 1 -C 6 ) alkylsulfonyl group, (v ) an N (R 4 ) R 5 group in which R 4 and R 5 are as defined above, (w) an N (R 4 ) COR 5 group in which R 4 and R 5 are as defined above, (x) one group N (R 4 ) CO2R 5 where R 4 and R 5 are as defined above, (y) a group N (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR group 4 where R 4 is as defined above, (aa) a CO2R 4 group where R 4 is as defined above, (bb) a CON group (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c80) an aryloxy group; (c81) an aryloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group ( C1C 6 ) alkyl, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 -C 6 ) alkoxy group, (g) a halo (C 1 -C 6 ) alkoxy group, ( h) a (C 2 -C 6 ) alkenyloxy group, (i) a (C 2 -C 6 ) alkenyloxy halo group, (j) a (C 2 -C 6 ) alkynyloxy group, (k) a halo group (C 2 -C 6 ) alkynyloxy, (l) a (C 3 -C 6 ) cycloalkoxy group, (m) a halo (C 3 -C 6 ) cycloalkoxy group, (n) a (C 3 -C 6 ) cycloalkyl group ( C 1 C 6 ) alkoxy, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (p) a (C 1 -C 6 ) alkylthio group, (q) a halo group (C 1 -C 6 ) alkylthio, (r) a (C 1 C 6 ) alkylsulfinyl group, (s) a halo (C 1 -C 6 ) alkylsulfinyl group, (t) a (C 1 - C 6 ) alkyl sulfonyl, (u) a halo (C 1 -C 6 ) alkyl sulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w ) a group N (R 4 ) COR 5 where R 4 and R 5 are as defined above, (x) an N group (R 4 ) CO 2 R 5 where R 4 and R 5 are as defined above, (y) an N group (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a 21/150 group CO 2 R 4 where R 4 is as defined above, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c82) an aryloxy (C 1 -C 8 ) alkyl group; (c83) an aryloxy (C 1 -C 6 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a (C 1 -C 6 ) alkyl group, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 C 6 ) alkoxy group, (g) a halo group (C 1 -C 6 ) alkoxy, (h) a (C 2 C6) alkenyloxy group, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2C6) alkynyloxy group, (k) a halo group (C2-C6) alkynyloxy, (l) a (C3C6) cycloalkoxy group, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3C6) cycloalkyl (C1-C6) alkoxy group, (o) an halo (C3-C6) cycloalkyl (C1C6) alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1C6) alkylthio group, (r) a (C1-C6) alkylsulfinyl group, (s) a halo (C1C6) alkylsulfinyl group, (t) a (C1-C6) alkylsulfonyl group, (u) a halo (C1-C6) alkylsulfonyl group, (v) an N (R) group 4 ) R 5 where R 4 and R 5 are as defined above, (w) an N (R 4 ) COR 5 group where R 4 and R 5 are as defined from the above, (x) an N (R 4 ) CO2R 5 group where R 4 and R 5 are as defined above, (y) an N (R 4 ) SO2R 5 group where R 4 and R 5 are as defined above , (z) a COR 4 group in which R 4 is as defined above, (aa) a CO2R 4 group in which R 4 is as defined above, (bb) a CON (R 4 ) R 5 group in which R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c84) an arylthio group; (c85) an arylthio group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group ( C1C6) alkyl, (e) a halo (C1-C6) alkyl group, (f) an (C1-C6) alkoxy group, 22/150 (g) a halo (C 1 -C 6 ) alkoxy group, (h) a (C 2 -C 6 ) alkenyloxy group, (i) a halo (C 2 -C 6 ) alkenyloxy group, (j) a (C 2 -C 6 ) alkynyloxy group, (k) a halo (C 2 -C 6 ) alkynyloxy group, (l) a (C 3 -C 6 ) cycloalkoxy group, (m) a halo group (C 3 - C 6 ) cycloalkoxy, (n) a (C 3 -C 6 ) cycloalkyl (C 1 C 6 ) alkoxy group, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, ( p) a (C 1 -C 6 ) alkylthio group, (q) a halo (C 1 -C 6 ) alkylthio group, (r) a (C 2 C 6 ) alkylsulfinyl group, (s) a halo group ( C 2 -C 6 ) alkylsulfinyl, (t) a (C 1 -C 6 ) alkylsulfonyl group, (u) a halo (C 1 -C 6 ) alkylsulfonyl group, (v) an N ( R 4 ) R 5 where R 4 and R 5 are as defined above, (w) an N group (R 4 ) COR 5 where R 4 and R 5 are as defined above, (x) an N group (R 4 ) CO2R 5 where R 4 and R 5 are as defined above, (y) an N group (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a CO 2 group R 4 where R 4 is as defined above, (bb) a CON group (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c86) a halo (C 1 -C 8 ) alkylenedioxy group; (c87) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy group; (c88) a (C3-C8) alkylene group; (c89) a (C 1 -C 8 ) alkyl (C 3 -C 8 ) alkylene group; (c90) a tri (C 1 -C 8 ) alkyl silyloxy group in which the alkyls can be the same or different; (c91) a tri (C 1 -C 8 ) alkylsilyl (C 1 -C 8 ) alkoxy group in which the alkyls can be the same or different; (C92) a di (C 1 -C 8) alkyl, halo (C 1 -C 8) alkyl silyl in which the alkyls may be the same or different; (c93) a di (C1-C8) alkyl (C1-C8) alkylthio (C1-C8) alkylsilyl group in which the alkyls can be the same or different; (c94) a di (C1-C8) alkylhydroxy-silyl group in which the alkyls can be the same or different; 23/150 (c95) a di (C 1 -C 8 ) alkyl-hydro-silyl group in which the alkyls can be the same or different; (c96) a di (C 1 -C 8 ) alkylphenyl silyl group in which the alkyls can be the same or different; (c97) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkoxy group; (c98) a (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkoxy group; (c99) a (C 1 -C 8 ) alkylsulfonyl (C 1 -C 8 ) alkoxy group; (c100) an (C 1 -C 8 ) alkoxycarbonyl (C 1 -C 8 ) alkoxy group; (c101) a (C 1 -C 8 ) alkylcarbonyl (C 1 -C 8 ) alkoxy group; (c102) a cyano (C 1 -C 8 ) alkoxy group; (c103) an aryl (C 1 -C 8 ) alkoxy group in which the alkoxy moiety can be halogenated; (c104) an aryl (C 1 -C 8 ) alkoxy group in which the alkoxy moiety can be halogenated which has, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b ) a cyano group, (c) a nitro group, (d) a (C 1 -C 6 ) alkyl group, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 - C 6 ) alkoxy, (g) a halo (C 1 -C 6 ) alkoxy group, (h) a (C 2 -C 6 ) alkenyloxy group, (i) a halo (C 2 C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2C6) alkynyloxy group, (l) a (C3-C6) cycloalkoxy group, (m) a halo (C3C 6 ) cycloalkoxy group, (n) a group ( C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (p) a (C 1 -C 6 group) ) alkylthio, (q) a halo (C 1 -C 6 ) alkylthio group, (r) a (C 2 -C 6 ) alkylsulfinyl group, (s) a halo (C 2 -C 6 ) alkylsulfinyl group , (t) a (C 1 -C 6 ) alkylsulfonyl group, (u) a halo (C1-C6) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w) an N (R 4 ) COR 5 group in which R 4 and R 5 are as defined above, (x) an N (R 4 ) CO2R 5 group in which R 4 and R 5 are in accordance defined above, (y) a group N (R 4 ) SO 2 R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a group 24/150 CO 2 R 4 where R 4 is as defined above, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c105) a hydroxy (C 1 -C 8 ) alkyl group; (c106) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkylcarbonyl group; (c107) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; (c108) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkylthio group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (c109) a tri (C 1 -C 8 ) alkylsilyl (C 1 -C 8 ) alkylsulfinyl group wherein the alkyls of the tri (C 1 -C 8 ) alkylsilyl group can be the same or different; (c110) a tri (C 1 -C 8 ) alkylsilyl (C 1 -C 8 ) alkylsulfonyl group in which the alkyls of the tri (C1-C8) alkylsilyl group can be the same or different; (c111) an R 4 (R 5 ) N (C1-C8) alkyl group in which R 4 and R 5 are as defined above; (c112) a heterocyclic group; (c113) a heterocyclic group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C1-C6) alkyl group, (f) a halo (C1-C6) alkyl group, (g) a (C1-C6) alkoxy group, (h) a halo (C1-C6) alkoxy group , (i) a (C3C6) cycloalkyl (C1-C6) alkoxy group, (j) a (C1-C6) alkylthio group, (k) a halo (C1-C6) alkylthio group, (l) a (C1- C6) alkylsulfinyl, (m) a halo (C1-C6) alkylsulfinyl group, (n) a (C1-C6) alkylsulfonyl group, (o) a halo (C1-C6) alkylsulfonyl group, (p) an (C1-C6) alkylcarbonyl group, (q) a carboxyl group, (r) an (C1-C6) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) a (C2-C6) alkynyl group, (u) a tri (C1-C6) alkylsilyl (C1) group 25/150 C 6 ) alkyl in which the alkyl of the tri (C 1 -C 6 ) alkyl silyl group can be the same or different, (v) a tri (C 1 -C 6 ) alkyl silyl (C 2 -C 6) group ) alkynyl where the alkyls may be the same or different and (w) an oxo group; (c114) a heterocyclyloxy group; (c115) a heterocyclyloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a group halo (C 1 -C 6 ) alkylthio, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo (C 1 -C 6 ) alkyl sulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) an (C 2 -C 6 ) alkynyl group, (u) a tri (C 1 -C 6 ) alkyl silyl (C 1 C 6 ) alkyl group in which the alkyls of the tri (C 1 -C 6 ) alkyl silyl group can be same or different, (v) a tri (C 1 -C 6 ) alkylsilyl (C 2 C 6 ) alkynyl group in which the alkyls can be the same or different and (w) an oxo group; (c116) a heterocyclylthio group; (c117) a heterocyclylthio group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a group halo (C 1 -C 6 ) alkylthio, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, 26/150 (o) a halo (C 1 -C 6 ) alkyl sulfonyl group, (p) a (C 1 C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 C 6 ) group ) alkoxycarbonyl, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) a (C2-C6) alkynyl group, (u) a tri (C 1 - C 6 ) alkyl silyl (C 1 -C 6 ) alkyl where the alkyls of the tri (C 1 C 6 ) alkyl silyl group can be the same or different, (v) a tri (C 1 C 6 ) alkyl group -silyl (C 2 -C 6 ) alkynyl in which the alkyls can be the same or different and (w) an oxo group; (c118) a heterocyclyl sulfinyl group; (c119) a heterocyclyl sulfinyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a group (C 1 -C 6 ) alkyl sulfonyl, (o) a halo group (C 1 -C 6 ) alkyl sulfonyl, (p) a (C 1 C6) alkylcarbonyl group, (q) a carboxyl group, (r) an (C1C6) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) an (C2-C6) alkynyl group, (u) a tri group (C1-C6) alkyl silyl (C1-C6) alkyl where the alkyls of the tri (C1C6) alkyl sily group can be the same or different es, (v) a tri (C1C6) alkylsilyl (C2-C6) alkynyl group in which the alkyls can be the same or different and (w) an oxo group; (c120) a heterocyclyl sulfonyl group; (c121) a heterocyclyl sulfonyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C1-C6) alkyl group, (f) a halo group (C1 27/150 C 6 ) alkyl, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1) group -C 6 ) alkoxy, (j) a (C 1 C 6 ) alkylthio group, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 C 6 ) alkylsulfinyl group, ( m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, ( p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) a (C 2 -C 6 ) alkynyl group, (u) a tri (C 1 -C 6 ) alkyl silyl (C 1 -C 6 ) alkyl group in which the alkyls of the tri (C 1 C 6 ) alkyl silyl group can be the same or different, (v) a tri (C 1 C 6 ) alkyl silyl (C 2 -C 6 ) alkynyl group in which the alkyls can be the same or different and (w) an oxo group; (c122) a heterocyclyl (C 1 -C 8 ) alkyloxy group; (c123) a heterocyclyl (C 1 -C 8 ) alkyloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C 6 ) alkyl group, (g) an (C 1 -C 6 ) alkoxy group , (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 C6) alkylthio group, (k) a halo (C1-C6) alkylthio group, (l) a (C1C6) alkylsulfinyl group, (m) a halo (C1-C6) alkylsulfinyl group, (n) a (C1-C6) group alkylsulfonyl, (o) a halo (C1-C6) alkylsulfonyl group, (p) a (C1-C6) alkylcarbonyl group, (q) a carboxyl group, (r) an (C1C6) alkoxycarbonyl group, (s ) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) an (C2-C6) alkynyl group, (u) a tri (C1-C6) alkylsilyl group ( C1-C6) alkyl where the alkyls of the tri (C1C6) alkyl silyl group can be the same or different, (v) a group the tri (C1C6) alkylsilyl (C2-C6) alkynyl wherein the alkyls can be the same or different and (w) an oxo group; (c124) a (C1-C8) alkyl (C3-C8) cycloalkyl group; 28/150 (c125) a halo (C 1 -C 8 ) alkyl (C 3 -C 8 ) cycloalkyl group; (c126) a (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkyl group; (c127) a di (C 1 -C 8 ) alkylbenzylsilyl group in which the alkyls can be the same or different; (c128) a heterocyclyl (C 1 -C 8 ) alkyl group; (c129) a heterocyclyl (C 1 -C 8 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C1-C6) alkyl group, (f) a halo (C1-C6) alkyl group, (g) an (C 1 -C 6 ) alkoxy group, (h ) a halo (C 1 -C 6 ) alkoxy group, (i) a (C3-C6) cycloalkyl (C1-C6) alkoxy group, (j) a (C1-C6) alkylthio group, (k) a halo group ( C1-C6) alkylthio, (l) a (C1-C6) alkylsulfinyl group, (m) a halo (C1-C6) alkylsulfinyl group, (n) a (C1-C6) alkylsulfonyl group, (o) a halo (C1-C6) alkylsulfonyl group, (p) a (C1-C6) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) a group R 4 (R 5 ) N carbonyl where R 4 and R 5 are as defined above, (t) a (C 2 -C 6 ) alkynyl group, (u) a tri (C 1 C 6 ) alkyl silyl group ( C 1 -C 6 ) alkyl where the alkyls of the tri (C 1 -C 6 ) alkylsilyl group can be the same or different, (v) a g tri (C 1 -C 6 ) alkylsilyl (C 2 -C 6 ) alkynyl group in which the alkyls can be the same or different and (w) an oxo group, (c130) a heterocyclyloxy (C 1 -C 8 ) alkyl group ; or (c131) a heterocyclyloxy (C 1 -C 8 ) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 group) ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, ( n) a group (C 1 -C 6 ) 29/150 alkylsulfonyl, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a group (C 1 -C 6 ) alkoxycarbonyl, (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above, (t) an (C 2 -C 6 ) alkynyl group, (u ) a tri (C 1 -C 6) alkyl-silyl (C 1 -C 6) alkyl in which the alkyls tri (C 1 -C 6) alquilsilila may be the same or different, (v) a tri ( C 1 -C 6 ) alkylsilyl (C 2 -C 6 ) alkynyl where the alkyls can be the same or different and (w) an oxo group or X may form, together with the adjacent R 2 or R 3 , (C132) a bicyclic ring, in which the bicyclic ring optionally having the same or different one or more substituents selected from (a) a halogen atom, (b) a (C 1 -C 6 ) alkyl group, (c) a halo (C 1 -C 6 ) alkyl group, (d) a (C 1 -C 6 ) alkoxy group, (e) a halo (C 1 -C) group 6 ) alkoxy, (f) a (C 1 -C 6 ) alkylthio group, (g) a halo (C 1 -C 6 ) alkylthio group, (h) a (C 1 -C 6 ) alkylsulfinyl group, ( i) a halo (C 1 -C 6 ) alkylsulfinyl group, (j) a (C 1 -C 6 ) alkylsulfonyl group and (k) a halo (C 1 -C 6 ) alkylsulfonyl group; or X may form, together with X on an aromatic ring, (C133) a bicyclic ring or (C134) a fused ring, in which the bicyclic ring or fused ring optionally has the same or different one or more substituents selected from (a) a halogen atom, (b) a (C 1 -C 6 ) alkyl group, (c) a halo (C 1 -C 6 ) alkyl group, (d) an (C 1 -C 6 ) alkoxy group, (and ) a halo (C 1 -C 6 ) alkoxy group, (f) a (C 1 C 6 ) alkylthio group, (g) a halo (C 1 -C 6 ) alkylthio group, (h) a (C 1 C 6 ) alkylsulfinyl, (i) a halo (C 1 -C 6 ) alkylsulfinyl group, (j) a (C 1 -C 6 ) alkylsulfonyl group and (k) a halo group (C 1 -C 6 ) alkyl sulfonyl, Y is CH or a nitrogen atom, m is an integer from 0 to 5 and n is an integer from 0 or 1 or a salt thereof; [0008] [2] The arylalkyloxypyrimidine derivative according to [1] mentioned above, where Y, q, m and n are as defined in [1] 30/150 mentioned above, R 1 is (a1) a halogen atom; (a2) a formyl group; (a3) a cyan group; (a4) a (C 1 -C 8 ) alkyl group; (a5) a (C 3 -C 8 ) cycloalkyl group; (a6) an (C 2 -C 8 ) alkenyl group; (a7) an (C 2 -C 8 ) alkynyl group; (a8) a halo (C 1 -C 8 ) alkyl group; (a11) a halo (C2-C8) alkynyl group; (a12) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (a13) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (a14) a (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkyl; (a16) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; (a17) a (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkyl group; (a18) a (C 1 -C 8 ) alkyl sulfonyl (C 1 -C 8 ) alkyl group; (a27) an R 4 (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined in [1] mentioned above; (a31) an aryl group; (a32) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C1-C6) alkylthio, (l) a (C1-C6) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) group alkylsulfonyl, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 ) group -C 6 ) alkoxycarbonyl, (s) a 31/150 group R 4 (R 5 ) N carbonyl where R 4 and R 5 are as defined above and (t) a phenoxy group; (a33) an aryl (C 1 -C 8 ) alkyl group; (a37) an arylthio (C 1 -C 8 ) alkyl group; (a39) an arylsulfinyl (C 1 -C 8 ) alkyl group; (a41) an arylsulfonyl (C 1 -C 8 ) alkyl group; (a43) a (C 1 -C 8 ) alkylcarbonyl group; (a45) an (C 1 -C 8 ) alkoxycarbonyl group; (a46) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a47) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl; (a49) a heterocyclic group; (a50) a heterocyclic group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C 1 -C 6 ) alkylthio, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl, (o) a halo group (C 1 -C 6 ) alkyl sulfonyl, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above, (t) a phenyl group, (u) an oxo group and ( v) a (C 1 C6) alkoxycarbonyl (C 1 -C 6) alkyl group; (a51) a heterocyclyl (C1-C8) alkyl group; (a56) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (a57) an oxiranyl group; (a65) a hydroxy (C1-C8) alkyl group; 32/150 (a66) an aryloxy (C 1 -C 8 ) alkyl group; (a67) an aryloxy group (C 1 -C 8 ) alkyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 group) ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group , (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q ) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a81) a (heterocyclyl) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a83) a di (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxy group can be the same or different; (a84) a di (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group in which the alkyls of the di (C 1 -C 8 ) alkylthio group can be the same or different; (a85) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a86) a carboxyl group; (a87) an aryloxycarbonyl group; (a88) a group C (R 4 ) = NOSO 2 R 5 where R 4 and R 5 are as defined above; (a89) a heterocyclylimino (C 1 -C 8 ) alkyl group; (a90) a tri (C 1 -C 8 ) alkyl silyl (C 2 -C 8 ) alkynyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a91) a (C 1 -C 8 ) alkoxy (C 2 -C 8 ) alkynyl group; 33/150 (a92) a hydroxy (C 2 -C 8 ) alkynyl group; (a93) a (hydroxy) ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a94) a dihydroxy (C 1 -C 8 ) alkyl group; (a95) a (hydroxy) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a96) a di (C 1 -C 8 ) alkylsulfonyloxy (C 1 -C 8 ) alkyl group wherein the alkyls of the di (C 1 -C 8 ) alkylsulfonyloxy group can be the same or different; (a97) a di ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group in which the alkoxys of the di ((C 1 -C 8 ) alkoxy (C 1- C 8 ) alkoxy can be the same or different; (a98) a di (C 1 -C 8 ) alkoxycarbonyl (C 2 -C 8 ) alkenyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxycarbonyl group can be the same or different; (a99) an (C 1 -C 8 ) alkoxycarbonyl (cyano) (C 2 -C 8 ) alkenyl group; (a100) an ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (hydroxy) (C 1 -C 8 ) alkyl group; (a101) an alkenyl dichian (C2-C8) group; (a102) a (C3-C8) cycloalkylidene (C1-C8) alkyl group; (a103) a (C3-C8) cycloalkyl (hydroxy) (C1-C8) alkyl group; (a104) a (C3-C8) cycloalkyl ((C1-C8) alkoxy) (C1-C8) alkyl group; (a105) a heterocyclyl (C2-C8) alkenyl group; (a106) a heterocyclyl (C2-C8) alkenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 C6) alkyl group, (g) a (C1-C6) alkoxy group, (h) a halo (C1-C6) alkoxy group, (i) a (C3-C6) cycloalkyl (C1-C6) alkoxy group, (j) a (C1-C6) al group 34/150 quiltio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group , (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q ) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) an oxo group ; (a107) a halo (C 1 -C 8 ) alkylcarbonyloxy (C 2 -C 8 ) alkenyl group; (a108) a (C 3 -C 8 ) cycloalkyl (halo (C 1 -C 8 ) alkylcarbonyloxy) (C1-C8) alkyl group; (a109) an (C 1 -C 8 ) alkoxycarbonyl (hydroxy) (C 1 -C 8 ) alkyl group; (a110) a carboxy (hydroxy) (C1-C8) alkyl group; (a111) a di (C1-C8) alkoxycarbonyl (C3-C8) cycloalkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; (a112) a di (C1-C8) alkoxycarbonyl (C1-C8) alkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; (a113) a (C1-C8) alkylcarbonyl (C2-C8) alkenyl group; (a114) a hydroxy-halo (C1-C8) alkyl group; (a115) a dihydroxy halo (C1-C8) alkyl group; (a116) a (C1-C8) alkoxycarbonyl (C3-C8) cycloalkyl group; (a117) a cyano (C3-C8) cycloalkyl group; (a118) an (C1-C8) alkoxycarbonyl (C2-C8) alkenyl group; (a119) a cyano (C2-C8) alkenyl group; (a120) a ((C1-C8) alkoxy) (hydroxy) halo (C1-C8) alkyl group; (a121) an R 4 (R 5 ) N (C 1 -C 8) alkyl (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above; (a122) an R 4 (R 5 ) NCO (R 5 ) N (C1-C8) alkyl group where R 4 35/150 and R 5 are as defined above; (a123) a tri (C 1 -C 8 ) alkyl silyl (C 2 -C 8 ) alkynyl (C 2 -C 8 ) alkenyl where the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; or (a124) a structural formula Q 7 , Q 8 , Q 9 , Q 10 , Q 11 , Q 12 , Q 13 , Q 14 , Q 15 , Q 16 , Q 17 , Q 18 , Q 19 , Q 20 , Q 21 Q 22 , Q 23 , Q 24 , Q 25 , Q 26 , Q 27 , Q 28 or Q 29 where each structural formula and the symbols on it are as defined in [1] mentioned above, R 2 and R 3 can be the same or different and each is (b1) a hydrogen atom; or (b6) a halo (C 1 -C 8 ) alkyl group; X can be the same or different and each is (c1) a hydrogen atom; (c2) a halogen atom; (c4) a cyano group; (c5) a nitro group; (c10) a CO group (R 4 ) where R 4 is as defined above; (c14) a (C 1 -C 8 ) alkyl group; (c18) a halo (C 1 -C 8 ) alkyl group; (c22) a tri (C 1 -C 8 ) alkyl silyl group in which the alkyls can be the same or different; (c27) an (C 1 -C 8 ) alkoxy group; (c31) a halo (C 1 -C 8 ) alkoxy group; (c40) a halo (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkoxy; (c42) an (C 1 -C 8 ) alkylthio group; (c46) a halo (C 1 -C 8 ) alkylthio group; (c76) an aryl group; (c77) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom 36/150 nio, (b) a cyano group, (c) a nitro group, (d) a (C 1 -C 6 ) alkyl group, (e) a halo (C 1 -C 6 ) alkyl group, (f ) a (C 1 -C 6 ) alkoxy group, (g) a halo (C 1 -C 6 ) alkoxy group, (h) a (C 2 -C 6 ) alkenyloxy group, (i) a halo (C2-) group C6) alkenyloxy, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a (C3-C6) cycloalkoxy group, (m) a halo (C3-) group C6) cycloalkoxy, (n) a (C3-C6) cycloalkyl (C1-C6) alkoxy group, (o) a halo (C3-C6) cycloalkyl (C1-C6) alkoxy group, (p) a (C1-C6) group ) alkylthio, (q) a halo (C1-C6) alkylthio group, (r) a (C1-C6) alkylsulfinyl group, (s) a halo (C 1 -C 6 ) alkylsulfinyl group, (t) a (C 1 C 6 ) alkyl sulfonyl group, (u) a halo (C 1 -C 6 ) alkyl sulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are in accordance defined above, (w) an N (R 4 ) COR 5 group where R 4 and R 5 are as defined above, (x) an N (R 4 ) CO2R 5 group where R 4 and R 5 are as defined above , (y) an N (R 4 ) SO2R 5 group in which R 4 and R 5 are as defined above, (z) a COR 4 group in which R 4 is as defined above, (aa) a CO2R 4 group in which R 4 is as defined above, (bb) a CON group (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c80) an aryloxy group; or (c81) an aryloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group (C 1 -C 6 ) alkyl, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 -C 6 ) alkoxy group, (g) a halo group (C 1 -C 6 ) alkoxy, (h) a (C 2 -C 6 ) alkenyloxy group, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo group (C2 -C6) alkynyloxy, (l) a (C3-C6) cycloalkoxy group, (m) a halo (C 3 -C 6 ) cycloalkoxy group, (n) a (C 3 -C 6 ) cycloalkyl (C 1 C6) group alkoxy, (o) a halo (C3-C6) cycloalkyl (C1-C6) alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1-C6) alkylthio group, (r) a (C1C6) alkylsulfinyl group, (s) a halo (C1-C6) alkylsulfinyl group, (t) a group 37/150 (C 1 -C 6 ) alkyl sulfonyl, (u) a halo (C 1 -C 6 ) alkyl sulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w) an N (R 4 ) COR 5 group in which R 4 and R 5 are as defined above, (x) an N (R 4 ) CO2R 5 group in which R 4 and R 5 are in accordance defined above, (y) a group N (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a CO 2 group R 4 where R 4 is as defined above, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; or a salt thereof; [0009] [3] An agricultural insecticide comprising the arylalkyloxypyrimidine derivative according to [1] or [2] mentioned above or a salt thereof as an active ingredient; [0010] [4] A method of using an agricultural insecticide, which comprises treating a plant or soil with the arylalkyloxypyrimidine derivative according to [1] or [2] mentioned above or a salt thereof; [0011] [5] A method of controlling an agricultural pest, which comprises treating a plant or soil with the arylalkyloxypyrimidine derivative according to [1] or [2] mentioned above or a salt thereof; [0012] [6] Use of the arylalkyloxypyrimidine derivative according to [1] or [2] mentioned above or a salt thereof as an agricultural insecticide; [0013] [7] Use of the arylalkyloxypyrimidine derivative according to [1] or [2] mentioned above or a salt thereof as a veterinary insecticide; [0014] [8] An arylalkyloxypyrimidine derivative represented by formula (II): 38/150 r2r3 R L7 ( x ) m (II) where R 1 , R swimming above and 2 , R 3 , X, Y, meq are as defined in [1] mentioned Hal is a halogen atom or a salt thereof; and the like. Effect of the Invention [0015] The arylalkyloxypyrimidine derivative of the present invention or a salt thereof has a superior effect as an agricultural insecticide. On the other hand, the derivative shows an effect on pests that are parasitic on pets, such as dogs and cats, and domestic animals, such as cattle, sheep and the like. Description of Modalities [0016] In the definition of the arylalkyloxypyrimidine derivative of formula (I) of the present invention: [0017] The term halo means a halogen atom and is a chlorine atom, a bromine atom, an iodine atom or a fluorine atom. [0018] (C1-C8) alkyl is, for example, a straight chain or branched chain alkyl having 1 to 8 carbon atoms such as a methyl group, an ethyl group, a normal propyl group, an isopropyl group, a group normal butyl, an isobutyl group, a secondary butyl group, a tertiary butyl group, a normal pentyl group, an isopentyl group, a tertiary pentyl group, a neopentyl group, a 2,3-dimethylpropyl group, a 1-ethylpropyl group, a 1-methylbutyl group, a 2-methylbutyl group, a normal hexyl group, an isohexyl group, a 2-hexyl group, a 3-hexyl group, a 2-methylpentyl group, a 3-methylpentyl group, a group 1, 1,2-trimethylpropyl, a 3,339 / 150 dimethylbutyl group, a normal heptyl group, a 2-heptyl group, a 3heptyl group, a 2-methylhexyl group, a 3-methylhexyl group, a 4methylhexyl group, an isoheptyl group, a normal octyl group and the like. [0019] (C 2 -C 8 ) alkenyl is, for example, a straight chain or branched chain alkenyl having 2 to 8 carbon atoms, such as a vinyl group, an allyl group, an isopropenyl group, a 1butenyl group, a 2-butenyl group, a 2-methyl-2-propenyl group, a group 1-methyl-2-propenyl, a 2-methyl-1-propenyl group, a pentenyl group, a 1-hexenyl group, a 3,3-dimethyl-1-butenyl group, a heptenyl group, an octenyl group and the like. [0020] (C2-C8) alkynyl is, for example, a straight chain or branched chain alkynyl having 2 to 8 carbon atoms, such as an ethynyl group, a 1-propynyl group, a 2-propynyl group, a group 1-butynyl, a 2-butynyl group, a 3-butynyl group, a 3-methyl-1propynyl group, a 2-methyl-3-propynyl group, a pentynyl group, a 1hexinyl group, a 3-methyl-1- group butynyl, a 3,3-dimethyl-1-butynyl group, a heptinyl group, an octinyl group and the like. [0021] (C3-C8) cycloalkyl is, for example, a cyclic alkyl having 3 to 8 carbon atoms, such as a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group , a cyclooctyl group and the like. [0022] (C3-C8) cycloalkylidene group is, for example, a cyclic alkylidene group having 3 to 8 carbon atoms, such as a cyclopropylidene group, a cyclobutylidene group, a cyclopentylidene group, a cyclohexylidene group, a cyclo group -heptilidene, a cyclooctylidene group and the like. [0023] (C1-C8) alkoxy is, for example, a straight chain or branched chain alkoxy having 1 to 8 carbon atoms, such as a methoxy group, an ethoxy group, a normal propoxy group, an isopropoxy group, a normal butoxy group, secondary butoxy group, tertiary butoxy group, normal pentyloxy group, isopentyloxy group, tertiary pentyloxy group, neopentyloxy group, 2,3dimethylpropyloxy group, 1-ethylpropyloxy group, 1 group -methylbutyloxy, a normal hexyloxy group, an isohexyloxy group, a 1,1,2-trimethylpropyloxy group, a normal heptyloxy group, a normal octyloxy group and the like. [0024] (C 2 -C 8 ) alkenyloxy is, for example, a straight chain or branched chain alkenyloxy having 2 to 8 carbon atoms, such as a propenyloxy group, a butenyloxy group, a pentenyloxy group, a hexenyloxy group, a heptinyloxy group, an octenyloxy group and the like. [0025] (C2-C8) alkynyloxy is, for example, a straight-chain or branched-chain alkynyloxy having 2 to 8 carbon atoms, such as a propynyloxy group, a butenyloxy group, a pentynyloxy group, a hexynyloxy group, a group heptinyloxy, an octinyloxy group and the like. [0026] Examples of the (C 1 -C 8 ) alkylthio include a straight chain or branched chain alkylthio having 1 to 8 carbon atoms, such as a methylthio group, an ethylthio group, a normal propylthio group, an isopropylthio group, a normal butylthio group, secondary butylthio group, tertiary butylthio group, normal pentylthio group, isopentylthio group, tertiary pentylthio group, neopentylthio group, 2,3-dimethylpropylthio group, 1-ethylpropylthio group, 1methylbutylthio group, a normal hexylthio group, an isohexylthio group, a 1,1,2-trimethylpropylthio, a normal heptyl group, a normal octyl group and the like. [0027] Examples of (C 1 -C 8 ) alkylsulfinyl include a straight chain or branched chain alkylsulfinyl having 1 to 8 carbon atoms, such as methylsulfinyl, ethylsulfinyl, normal propylsulfinyl, isopropylsulfinyl , normal butylsulfinyl, secondary butylsulfinyl, tertiary butylsulfinyl, normal pentylsulfinyl, isopentylsulfinyl, pentyl-sul 41/150 tertiary finyl, neopentylsulfinyl, 2,3-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, 1-methylbutylsulfinyl, normal hexylsulfinyl, isohexylsulfinyl, 1,1,2-trimethylpropyl sulfinyl, normal heptyl sulfinyl, normal octyl sulfinyl and the like. [0028] Examples of (C 1 -C 8 ) alkyl sulfonyl include a straight chain or branched chain alkyl sulfonyl having 1 to 8 carbon atoms, such as methyl sulfonyl, ethyl sulfonyl, normal propyl sulfonyl, isopropyl sulfonyl , normal butylsulfonyl, secondary butylsulfonyl, tertiary butylsulfonyl, normal pentylsulfonyl, isopentylsulfonyl, tertiary pentylsulfonyl, neopentylsulfonyl, 2,3-dimethylpropylsulfonyl, 1ethylpropylsulfonyl, 1-methylbutylsulfonyl, normal hexyl sulfonyl, isohexyl sulfonyl, 1,1,2-trimethylpropyl sulfonyl, normal heptyl sulfonyl, normal octyl sulfonyl and the like. [0029] Examples of (C 2 -C 8 ) alkenylthio include a straight chain or branched chain alkenylthio having 2 to 8 carbon atoms, such as a propenylthio group, a buthenylthio group, a pentenylthio group, a hexenylthio group, heptenylthio, an octenylthio group and the like. [0030] Examples of (C2-C8) alkynylthio include a straight-chain or branched-chain alkynylthio having 2 to 8 carbon atoms, such as a propynylthio group, a butynylthio group, a pentinylthio group, a hexynylthio group, a heptinylthio group, an octinylthio group and the like. [0031] Examples of (C2-C8) alkenylsulfinyl include a straight chain or branched chain alkenylsulfinyl having 1 to 8 carbon atoms, such as propenylsulfinyl, butenylsulfinyl, pentenylsulfinyl, hexenylsulfinyl, heptenyl- sulfinyl, octenyl-sulfinyl and the like. [0032] Examples of (C2-C8) alkynylsulfinyl include a straight chain or branched chain alkynylsulfinyl having 2 to 8 carbon atoms, such as propynylsulfinyl, butinylsulfinyl, pentynylsulfinyl, hexynylsulfinyl, heptinyl- sulfinyl, octinyl-sulfinyl and the like. [0033] Examples of (C2-C8) alkenyl sulfonyl include a 42/150 straight chain or branched chain nil sulfonyl having 2 to 8 carbon atoms, such as propenyl sulfonyl, butenyl sulfonyl, pentenyl sulfonyl, hexenyl sulfonyl, heptenyl sulfonyl, octenyl sulfonyl and the like. [0034] Examples of (C 2 -C 8 ) alkynyl sulfonyl include a straight chain or branched chain alkynyl sulfonyl having 2 to 8 carbon atoms, such as propynyl sulfonyl, butynyl sulfonyl, pentynyl sulfonyl, hexynyl sulfonyl, heptinyl-sulfonyl, octinyl-sulfonyl and the like. [0035] The (C3-C8) cycloalkyloxy is, for example, a cyclic alkyloxy having 3 to 8 carbon atoms, such as a cyclopropoxy group, a cyclobutoxy group, a cyclopentyloxy group, a cyclohexyloxy group, a cyclo- heptyloxy, a cyclooctyloxy group and the like. [0036] (C 3 -C 8 ) cycloalkylthio is, for example, a cyclic alkylthio having 3 to 8 carbon atoms, such as a cyclopropylthio group, a cyclobutylthio group, a cyclopentylthio group, a cyclohexylthio group, a cyclo group -heptiltio, a cyclooctyl group and the like. [0037] (C 3 -C 8 ) cycloalkylsulfinyl is, for example, a cyclic alkylsulfinyl having 3 to 8 carbon atoms, such as cyclopropylsulfinyl, cyclobutylsulfinyl, cyclopentylsulfinyl, cyclohexylsulfinyl, cycloheptyl -sulfinyl, cyclooctyl-sulfinyl and the like. [0038] (C3-C8) cycloalkylsulfonyl is, for example, a cyclic alkylsulfonyl having 3 to 8 carbon atoms, such as cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, cycloheptyl sulfonyl , cyclooctyl-sulfonyl and the like. [0039] The groups (C 1 -C 8 ) alkyl, (C 2 -C 8 ) alkenyl, (C 2 -C 8 ) alkynyl, (C3-C8) cycloalkyl, (C3-C8) cycloalkyloxy, (C1-C8 ) alkoxy, (C2C 8 ) alkenyloxy, (C 2 -C 8 ) alkynyloxy, (C 1 -C 8 ) alkylthio, (C 1 -C 8 ) alkylsulfinyl, (C 1 -C 8 ) alkylsulfonyl, ( C 2 -C 8 ) alkenylthio, (C 2 -C 8 ) alkynylthio, (C2-C8) alkenylsulfinyl, (C2-C8) alkynylsulfinyl, (C2-C8) alkenylsulfonyl, (C 2 -C 8 ) alkynyl -sulfonyl, (C 3 -C 8 ) cycloalkyl, (C 1 -C 8 ) alkoxy, (C2-C8) alkenyloxy, (C2-C8) alkynyloxy, (C3-C8) cycloalkylthio, 43/150 (C 3 -C 8 ) cycloalkylsulfinyl and (C 3 -C 8 ) cycloalkylsulfonyl mentioned above can be replaced by one or more halogen atoms in replaceable position (s) and, when replaced by two or more halogen atoms, the halogen atoms can be the same or different. [0040] They are indicated as halo (C 1 -C 8 ) alkyl, halo (C 2 -C 8 ) alkenyl, halo (C 2 -C 8 ) alkynyl, halo (C 3 -C 8 ) cycloalkyl, halo (C 3 -C 8 ) cycloalkyloxy, halo (C 1 -C 8 ) alkoxy, halo (C 2 -C 8 ) alkenyloxy, halo (C 2 C8) alkynyloxy, halo (C1-C8) alkylthio, halo (C1-C8) alkyl -sulfinyl, halo (C 1 -C 8 ) alkyl sulfonyl, halo (C 2 -C 8 ) alkenylthio, halo (C 2 -C 8 ) alkynylthio, halo (C2-C8) alkenyl sulfinyl, halo (C2-C8 ) alkynylsulfinyl, halo (C2-C8) alkenylsulfonyl, halo (C2-C8) alkynylsulfonyl, halo (C3-C8) cycloalkyl, halo (C 1 -C 8 ) alkoxy, halo (C 2 -C 8 ) alkenyloxy, (C 2 -C 8 ) alkynyloxy, (C3-C8) cycloalkylthio halo, (C3-C8) cycloalkylsulfinyl halo (C3-C8) cycloalkylsulfonyl, respectively. [0041] The tri (C 1 -C 8 ) alkyl silyl group is, for example, a straight chain or branched chain trialkyl silyl group having 1 to 8 carbon atoms, such as a trimethyl silyl group, a group triethyl silyl, a tertiary butyldimethyl silyl group, an ethyldimethyl silyl group, an isopropyl dimethyl silyl group, an n-propyldimethyl silyl group and the like. In this case, the three alkyls can be the same or different. [0042] Examples of the di (C1-C8) alkylhalo (C1-C8) alkylsilyl group include a chloromethyldimethylsilyl group and the like. In this case, the two alkyls can be the same or different. [0043] Examples of the di (C1-C8) alkyl (C1-C8) alkylthio (C1-C8) alkyl silyl group include a methylthiomethyldimethyl silyl group and the like. In this case, the two alkyls can be the same or different. [0044] Examples of the di (C1-C8) alkylhydro-silyl group include the diisopropyl-silyl group, the dimethyl-silyl group and the like. In this case, the two alkyls can be the same or different. 44/150 [0045] Examples of the di (C 1 -C 8 ) alkyl hydroxy silyl group include the dimethyl hydroxy silyl group and the like. In this case, the two alkyls can be the same or different. [0046] Examples of the di (C 1 -C 8 ) alkylphenyl silyl group include the dimethyl (phenyl) silyl group and the like. In this case, the two alkyls can be the same or different. [0047] Examples of the di (C 1 -C 8 ) alkylbenzyl silyl group include the dimethyl (benzyl) silyl group and the like. In this case, the two alkyls can be the same or different. Examples of the aryl group include an aromatic hydrocarbon group having a carbon number of 6 to 10, such as a phenyl group, a 1-naphthyl group, a 2-naphthyl group and the like. [0049] The expressions (C 1 -C 8 ), (C 2 -C 8 ), (C 3 -C 8 ) and the like show ranges of the number of carbon atoms of various substituents. In addition, the definition mentioned above applies to groups in which the substituents mentioned above are linked to each other. For example, (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl means that a straight chain or branched chain alkoxy having a number of carbons from 1 to 8 is attached to a straight chain or branched chain having a number of carbons from 1 to 8. [0050] In addition, for example, ((C 1 -C 8 ) alkoxy) ((C 3 -C 8 ) cycloalkyl) (C1-C8) alkyl means that a straight chain or branched chain alkoxy having 1 to 8 atoms carbon and a cyclic alkyl having 3 to 8 carbon atoms are attached to a straight chain or branched chain having 1 to 8 carbon atoms. [0051] When two or more substituents are attached, each substituent can be attached to the same carbon atom or different carbon atoms. For example, in the ((C 1 -C 8 ) alkoxy) group ((C 3 -C 8 ) cycloalkyl) (C 1 -C 8 ) alkyl, the (C 1 -C 8 ) alkoxy and (C 3 -C 8) ) cycloalkyl may be attached to the same carbon atom or a carbon atom 45/150 other than (C 1 -C 8 ) alkyl. [0052] The groups (C 3 -C 8 ) alkylene, (C 1 -C 8 ) alkyl (C 3 -C 8 ) alkylene and halo (C 1 -C 8 ) alkylenedioxy are groups that can be formed together with the two adjacent X groups and examples of (C3-C8) alkylene and (C 1 -C 8 ) alkyl (C 3 -C 8 ) alkylene include a propylene group, a butylene group, a pentylene group, a hexylene group, a group 1.1.4.4- tetramethylbutylene and the like and examples of halo (C 1 -C 8 ) alkylenedioxy include a difluoromethylenedioxy group, a tetrafluoroethylenedioxy group and the like. [0053] Examples of the fused ring and bicyclic ring formed by two adjacent X's or the bicyclic ring formed by X together with adjacent R 2 or R 3 include fused rings such as tetrahydronaphthalene, naphthalene, benzodioxola, benzodioxane, indane, indole, benzofuran , benzothiophene, benzimidazole, benzothiazole, benzoxazole and the like and bicycles rings such as tetrahydronaphthalene, naphthalene, 1,2,3,4-tetrahydro- 1.4- methanonaphthalene, 1,2,3,4-tetrahydro-1,4-ethanonaphthalene and the like. [0054] Examples of the heterocyclic and heterocyclyl group include a 5- or 6-element monocyclic aromatic heterocyclic group or a 3- to 6-element monocyclic non-aromatic heterocyclic group, each of which contains, as a ring constituent atom, in addition to an atom carbon, 1 to 4 heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom, a fused heterocyclic group obtained by condensing the non-aromatic or aromatic monocyclic heterocycle with a benzene ring and a fused heterocyclic group obtained by condensation of aromatic or non-aromatic monocyclic heterocycles (heterocycles may be different). [0055] Examples of the aromatic heterocyclic group include monocyclic aromatic heterocyclic groups, such as furyl, thienyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, imidazolyl, pyrazole 46/150 la, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl and the like; fused aromatic heterocyclic groups, such as quinolyl, isoquinolyl, quinazolyl, quinoxalyl, benzofuranyl, benzothienyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, benzimidazolyl, benzotriazolyl, indolyl, indazolyl, pyridolazole, pyrrolazolazyrinopyrazole [0056] Examples of the nonaromatic heterocyclic group include heterocyclic groups nonaromatic monocyclic such as oxiranila, Ti-iranila, aziridinila, oxetanila, tietanila, azetidinyl, pyrrolidinyl, 2oxopirrolidin-1-ila, piperidinyl, morpholinyl, tiomorfolinila, piperazinyl, hexametileniminila, oxazolidinyl, thiazolidinyl, imidazolidinyl, oxazolinyl, thiazolinyl, isoxazolinyl, imidazolinyl, dioxolyl, dioxolanyl, dihydrooxadiazolyl, 2-oxo-1,3-oxazolidin-5-yl, 5-oxo-1,2,4-oxadiazolin-3- ila, 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, 1,3-dioxepan-2-yl, pyranyl, tetrahydropyranyl, thiopyranyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl 1-oxide, Tetrahydrothiopyranyl 1,1-dioxide, tetrahydrofuranyl, dioxanyl, pyrazolidinyl, pyrazolinyl, tetrahydropyrimidinyl, dihydrotriazolyl, tetrahydrotriazolyl and the like; fused non-aromatic heterocyclic groups such as dihydroindolyl, dihydroisoindolyl, dihydrobenzofuranyl, dihydrobenzodioxinyl, dihydrobenzodioxepinyl, tetrahydrobenzofuranyl, chromenyl, dihydroquinolinyl, tetrahydroquinolinyl, dihydroquinquinyl, dihydroquinquinyl hydrophthalazinyl and the like; and the like. [0057] Examples of the salts of the arylalkyloxypyrimidine derivative represented by formula (I) of the present invention include salts of inorganic acid, such as hydrochloride, sulfate, nitrate, phosphate and the like, salts of organic acid, such as acetate, fumarate, maleate, oxalate, methanesulfonate, benzenesulfonate, paratoluenesulfonate and the like and salts as inorganic or organic bases, such as an ion of 47/150 sodium, a potassium ion, a calcium ion, trimethylammonium and the like. [0058] The arylalkyloxypyrimidine derivative represented by formula (I) and a salt thereof of the present invention may contain one or multiple numbers of asymmetric centers in the structural formula and, in some cases, two or more optical isomers and diastereomers may be present. The present invention encompasses any of such optical isomers and mixtures containing them in any proportion. In addition, the arylalkyloxypyrimidine derivative represented by formula (I) and a salt thereof of the present invention can have two types of geometric isomers derived from a C-C double bond in the structural formula. The present invention encompasses all of such geometric isomers and mixtures containing them in any proportion. Preferred embodiments of the arylalkyloxypyrimidine derivative of formula (I) of the present invention are as follows. [0060] R 1 is preferably: (a1) a halogen atom; (a2) a formyl group; (a3) a cyan group; (a4) a (C 1 -C 8 ) alkyl group; (a5) a (C3-C8) cycloalkyl group; (a6) an (C2-C8) alkenyl group; (a7) an (C2-C8) alkynyl group; (a8) a halo (C 1 -C 8 ) alkyl group; (a11) a halo (C 2 -C 8 ) alkynyl group; (a12) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group; (a13) a (C 3 -C 8 ) cycloalkyl (C 1 -C 8 ) alkyl group; (a14) a (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkyl; (a16) a (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group; (a17) a (C 1 -C 8 ) alkylsulfinyl (C 1 -C 8 ) alkyl group; 48/150 (a18) a (C 1 -C 8 ) alkylsulfonyl (C 1 -C 8 ) alkyl group; (a27) an R 4 (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a31) an aryl group; (a32) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) alkoxy group, (h) a halo group (C 1 -C 6 ) alkoxy, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) alkylthio group, (k) a halo group (C1-C6) alkylthio, (l) a (C1-C6) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) group alkylsulfonyl, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) a (C 1 ) group -C 6 ) alkoxycarbonyl, (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above and (t) a phenoxy group; (a33) an aryl (C 1 -C 8 ) alkyl group; (a37) an arylthio (C 1 -C 8 ) alkyl group; (a39) an arylsulfinyl (C 1 -C 8 ) alkyl group; (a41) an arylsulfonyl (C 1 -C 8 ) alkyl group; (a43) a (C 1 -C 8 ) alkylcarbonyl group; (a45) an (C 1 -C 8 ) alkoxycarbonyl group; (a46) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a47) a (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl; (a49) a heterocyclic group; (a50) a heterocyclic group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a formyl group , (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a 49/150 (C 1 -C 6 ) alkoxy group, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 C6) cycloalkyl (C 1 -C 6 ) alkoxy group, (j ) a (C 1 -C 6 ) alkylthio group, (k) a (C 1 -C 6 ) alkylthio group, (1) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo group ( C 1 -C 6 ) alkylsulfinyl, (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C) group 1 -C 6 ) alkylcarbonyl, (q) a carboxyl group, (r) a (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 conform defined above, (t) a phenyl group, (u) an oxo group and (v) a (C 1 -C 6 ) alkoxycarbonyl (C 1 -C 6 ) alkyl group; (a51) a heterocyclyl (C 1 -C 8 ) alkyl group; (a56) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (a57) an oxiranyl group; (a65) a hydroxy (C 1 -C 8 ) alkyl group; (a66) an aryloxy (C 1 -C 8 ) alkyl group; (a67) an aryloxy group (C 1 -C 8 ) alkyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 ) group alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group, (n) a (C 1 -C 6 ) alkyl sulfonyl group, (o) a halo (C 1 -C 6 ) alkyl sulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group and (s) an R 4 (R 5 ) N carbonyl group where R 4 and R 5 are as defined above; (a81) a (heterocyclyl) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a83) a di (C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxy group can be the same or different; (a84) a di (C 1 -C 8 ) alkylthio (C 1 -C 8 ) alkyl group in which the 50/150 alkyls of the di (C 1 -C 8 ) alkylthio group can be the same or different; (a85) a tri (C 1 -C 8 ) alkyl silyl (C 1 -C 8 ) alkyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a86) a carboxyl group; (a87) an aryloxycarbonyl group; (a88) a group C (R 4 ) = NOSO 2 R 5 where R 4 and R 5 are as defined above; (a89) a heterocyclylimino (C 1 -C 8 ) alkyl group; (a90) a tri (C 1 -C 8 ) alkyl silyl (C 2 -C 8 ) alkynyl group wherein the alkyls of the tri (C 1 -C 8 ) alkyl silyl group can be the same or different; (a91) a (C 1 -C 8 ) alkoxy (C 2 -C 8 ) alkynyl group; (a92) a (C2-C8) hydroxy group alkynyl; (a93) a (hydroxy) ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a94) a dihydroxy (C 1 -C 8 ) alkyl group; (a95) a (hydroxy) ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a96) a di (C 1 -C 8 ) alkylsulfonyloxy (C 1 -C 8 ) alkyl group wherein the alkyls of the di (C 1 -C 8 ) alkylsulfonyloxy group can be the same or different; (a97) a di ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group in which the alkoxys of the di ((C 1 -C 8 ) alkoxy (C 1- C 8 ) alkoxy can be the same or different; (a98) a di (C 1 -C 8 ) alkoxycarbonyl (C 2 -C 8 ) alkenyl group in which the alkoxys of the di (C 1 -C 8 ) alkoxycarbonyl group can be the same or different; (a99) an (C 1 -C 8 ) alkoxycarbonyl (cyano) (C 2 -C 8 ) alkenyl group; (a100) an ((C 1 -C 8 ) alkoxy (C 1 -C 8 ) alkoxy) (hydroxy) (C 1 -C 8 ) alkyl group; 51/150 (a101) a dicyanic (C 2 -C 8 ) alkenyl group; (a102) a (C 3 -C 8 ) cycloalkylidene (C 1 -C 8 ) alkyl group; (a103) a (C 3 -C 8 ) cycloalkyl (hydroxy) (C 1 -C 8 ) alkyl group; (a104) a (C 3 -C 8 ) cycloalkyl ((C 1 -C 8 ) alkoxy) (C 1 -C 8 ) alkyl group; (a105) a heterocyclyl (C2-C8) alkenyl group; (a106) a heterocyclyl group (C 2 -C 8 ) alkenyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a group nitro, (d) a formyl group, (e) a (C 1 -C 6 ) alkyl group, (f) a halo (C 1 -C 6 ) alkyl group, (g) a (C 1 -C 6 ) group alkoxy, (h) a halo (C 1 -C 6 ) alkoxy group, (i) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (j) a (C 1 -C 6 group) ) alkylthio, (k) a halo (C 1 -C 6 ) alkylthio group, (l) a (C 1 -C 6 ) alkylsulfinyl group, (m) a halo (C 1 -C 6 ) alkylsulfinyl group , (n) a (C 1 -C 6 ) alkylsulfonyl group, (o) a halo (C 1 -C 6 ) alkylsulfonyl group, (p) a (C 1 -C 6 ) alkylcarbonyl group, (q) a carboxyl group, (r) an (C 1 -C 6 ) alkoxycarbonyl group, (s) an R 4 (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above and (t) an oxo group; (a107) a halo (C 1 -C 8 ) alkylcarbonyloxy (C 2 -C 8 ) alkenyl group; (a108) a (C 3 -C 8 ) cycloalkyl (halo (C 1 -C 8 ) alkylcarbonyloxy) (C1-C8) alkyl group; (a109) an (C 1 -C 8 ) alkoxycarbonyl (hydroxy) (C 1 -C 8 ) alkyl group; (a110) a carboxy (hydroxy) (C1-C8) alkyl group; (a111) a di (C1-C8) alkoxycarbonyl (C3-C8) cycloalkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; (a112) a di (C1-C8) alkoxycarbonyl (C1-C8) alkyl group in which the alkoxys of the di (C1-C8) alkoxycarbonyl group can be the same or different; 52/150 (a113) a (C 1 -C 8 ) alkylcarbonyl (C 2 -C 8 ) alkenyl group; (a114) a hydroxy-halo (C 1 -C 8 ) alkyl group; (a115) a dihydroxy halo (C1-C8) alkyl group; (a116) a (C 1 -C 8 ) alkoxycarbonyl (C 3 -C 8 ) cycloalkyl group; (a117) a cyano (C 3 -C 8 ) cycloalkyl group; (a118) an (C 1 -C 8 ) alkoxycarbonyl (C 2 -C 8 ) alkenyl group; (a119) a cyano (C 2 -C 8 ) alkenyl group; (a120) a ((C 1 -C 8 ) alkoxy) (hydroxy) halo (C 1 -C 8 ) alkyl group; (a121) an R 4 (R 5 ) N (C 1 -C 8 ) alkyl (R 5 ) N carbonyl group in which R 4 and R 5 are as defined above; (a122) an R 4 (R 5 ) NCO (R 5 ) N (C 1 -C 8 ) alkyl group in which R 4 and R 5 are as defined above; (a123) a tri (C1-C8) alkyl silyl (C2-C8) alkynyl (C2-C8) alkenyl group in which the alkyls of the tri (C1-C8) alkyl silyl group can be the same or different; or (a124) a structural formula Q 7 , Q 8 , Q 9 , Q 10 , Q 11 , Q 12 , Q 13 , Q 14 , Q 15 , Q 16 , Q 17 , Q 18 , Q 19 , Q 20 , Q 21 Q 22 , Q 23 , Q 24 , Q 25 , Q 26 , Q 27 , Q 28 or Q 29 where each structural formula and the symbols on it are as defined above. [0061] R 2 and R 3 can be the same or different and each is preferably: (b1) a hydrogen atom; or (b6) a halo (C 1 -C 8 ) alkyl group. [0062] Each X can be the same or different and is preferably: (c1) a hydrogen atom; (c2) a halogen atom; (c4) a cyano group; (c5) a nitro group; (c10) a CO group (R 4 ) where R 4 is as defined above; (c14) a (C 1 -C 8 ) alkyl group; 53/150 (c18) a halo (C 1 -C 8 ) alkyl group; (c22) a tri (C 1 -C 8 ) alkyl silyl group in which the alkyls can be the same or different; (c27) an (C 1 -C 8 ) alkoxy group; (c31) a halo (C 1 -C 8 ) alkoxy group; (c40) a halo (C 1 -C 8 ) alkoxy-halo (C 1 -C 8 ) alkoxy; (c42) an (C 1 -C 8 ) alkylthio group; (c46) a halo (C 1 -C 8 ) alkylthio group; (c76) an aryl group; (c77) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group ( C 1 -C 6 ) alkyl, (e) a halo (C 1 -C 6 ) alkyl group, (f) a (C 1 -C 6 ) alkoxy group, (g) a halo (C 1 -C 6 ) group alkoxy, (h) an (C 2 -C 6 ) alkenyloxy group, (i) a halo (C2-C6) alkenyloxy group, (j) an (C2-C6) alkynyloxy group, (k) a halo group (C 2 -C 6 ) alkynyloxy, (l) a (C 3 -C 6 ) cycloalkoxy group, (m) a halo (C 3 -C 6 ) cycloalkoxy group, (n) a (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy group, (p) a (C 1 -C 6 ) alkylthio group, (q) a halo group (C 1 -C 6 ) alkylthio, (r) a (C 1 -C 6 ) alkylsulfinyl group, (s) a halo (C 1 -C 6 ) alkylsulfinyl group, (t) a (C 1 -C 6 ) alkyl sulfonyl, (u) a halo (C 1 -C 6 ) alkyl sulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w) a group N (R 4 ) COR 5 where R 4 and R 5 are as defined above, (x) an N (R 4 ) CO2R 5 group where R 4 and R 5 are as defined above, (y) an N (R 4 ) SO 2 group R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group where R 4 is as defined above, (aa) a CO2R 4 group where R 4 is as defined above, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above; (c80) an aryloxy group; or 54/150 (c81) an aryloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a (C 1 -C 6 ) alkyl group, (e) a halo (C1-C6) alkyl group, (f) a (C1-C6) alkoxy group, (g) a halo (C 1 -C 6 ) alkoxy group , (h) an (C 2 -C 6 ) alkenyloxy group, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo group (C 2 - C 6 ) alkynyloxy, (l) a (C 3 -C 6 ) cycloalkoxy group, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1-C6) alkoxy group, (o) a halo (C 3 -C 6 ) cycloalkyl (C 1 -C 6 ) alkoxy, (p) a (C 1 -C 6 ) alkylthio group, (q) a halo (C 1 -C 6 ) group alkylthio, (r) a (C 1 -C 6 ) alkylsulfinyl group, (s) a halo (C 1 -C 6 ) alkylsulfinyl group, (t) a (C 1 C 6 ) alkylsulfonyl group, (u) a halo (C 1 -C 6 ) alkyl sulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined above, (w) an N (R 4 group) ) COLOR 5 in q u and R 4 and R 5 are as defined above, (x) a group N (R 4 ) CO2R 5 where R 4 and R 5 are as defined above, (y) a group N (R 4 ) SO2R 5 where R 4 and R 5 are as defined above, (z) a COR 4 group in which R 4 is as defined above, (aa) a CO2R 4 group in which R 4 is as defined above, (bb) a CON group (R 4 ) R 5 where R 4 and R 5 are as defined above and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined above. [0063] Like Y, CH is preferable. [0064] As q, 1 is preferable. [0065] As m, 1 or 2 is preferable. [0066] As n, 0 is preferable. [0067] Various derivatives of the present invention can be produced, for example, by means of the following production methods and the present invention is not limited to them. Production Method 55/150 HO x * ^ x X ^ X halogenation SAT.. JV) (11-1) halogenation X ^ XR 1 R 1 IV-D (at (11Γ) hydrogenation R 2 R J base R 1 (11) where R 1 , R 2 , R 3 , X, which are as defined above and Hal is a halogen atom. Production Methods of formula (11-1) from formula (IV) and formula (II-2) from formula (IV-1) [0068] O derivatives of formula (IV) and formula (IV- 1) being the starting materials can be produced using the methods described in Organic Process Research and Development, 1, 300 (1997), J. Amer. Chem. Soc., 77, 745 (1955), WO2001017975 and the like. [0069] The halogenopyrimidine derivatives represented by formulas (11-1) and (II-2) can be produced by reacting the 4-hydroxypyrimidine derivative (IV) or the 4,6-dihydroxypyrimidine derivative (IV -1) produced using the methods described in the documents mentioned above with 1 to 10 equivalents of a halogenating agent in an inert solvent. Examples of the halogenating agent include thionyl chloride, phosphorus oxychloride, phosphorus pentachloride, phosphorus (III) bromide and the like. The inert solvent can be any one, as long as it does not significantly inhibit the progress of the reaction and, for example, aliphatic hydrocarbons, such as hexane, cyclohexane, methylcyclohexane and the like, halogenated hydrocarbons, such as chloroform, dichloromethane, tetrachloride carbon and the like, aromatic hydrocarbons, such as benzene, xylene, toluene and the like or cyclic ethers, such as ethyl ether, methyl-butyl ether, dioxane, tetrahydrofuran, 1,2-dimethoxyethane and the like, ni 56/150 tryls, such as acetonitrile, propionitrile and the like or cyclic ketones, such as acetone, methyl isobutyl ketone, cyclohexanone and the like, esters, such as ethyl acetate, butyl acetate and the like can be mentioned. These inert solvents can be used alone or a mixture of two or more types of them can be used. The reaction temperature can be appropriately selected from 0 ° C to the reflux temperature of the inert solvent or halogenating agent to be used. Although the reaction time varies depending on the reaction scale, reaction temperature and the like and is not constant, it can be properly selected from several minutes to 100 hours. Although the reaction also proceeds in the presence of oxygen and the like in the air, it can be carried out in an atmosphere of inert gas, such as nitrogen gas, argon and the like. After the completion of the reaction, the target product is isolated from the reaction system containing the target product by means of a conventional method and purified as necessary through a recrystallization method, a distillation method, a column chromatography method and the like, to provide the target product. Production Methods of formula (I-1) from formula (II-1) and formula (II) from formula (II-2) [0070] In this reaction, from 1 to 3 equivalents of an alcohol derivative arylalkyl represented by formula (III) is reacted with an equivalent of a halogenopyrimidine derivative represented by formula (II-1) in an inert solvent in the presence of a base to provide an arylalkyloxypyrimidine derivative represented by formula (I-1). In addition, 1 to 1.2 equivalents of an arylalkyl alcohol derivative represented by formula (III) is reacted with an equivalent of a halopyrimidine derivative represented by formula (II-2) in an inert solvent in the presence of a base to provide an arylalkyloxypyrimidine derivative represented by 57/150 formula (II). The inert solvent that can be used for this reaction can be any one, as long as it does not significantly inhibit the progress of the reaction and, for example, cyclic ethers, such as diethyl ether, tetrahydrofuran, dioxane and the like, ketones, such as acetone, methyl ethyl ketone and the like, aromatic hydrocarbons, such as benzene, chlorobenzene and the like, nitriles, such as acetonitrile, propionitrile and the like, amides, such as dimethylformamide, dimethylacetamide, N-methylpyrrolidone and the like, dimethyl sulfoxide, sulfolane and the like and water can be mentioned. These inert solvents can be used alone or a mixture of two or more types of them can be used. Examples of the base that can be used for this reaction include inorganic bases, such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate and the like, alkali metal hydrides , such as sodium hydride, potassium hydride, etc., alkali metal alkoxides, such as sodium methoxide, sodium ethoxide, tertiary potassium butoxy and the like, alkyl lithiums, such as methyl lithium, normal butyl lithium and the like. The amount of the base to be used is, in general, from about 1.0 to 1.5 molar times in relation to the arylalkyl alcohol derivative represented by the formula (III). This reaction can be carried out under an atmosphere of inert gas (nitrogen gas, argon gas) in some cases. The reaction temperature can be appropriately selected from 0 ° C to the boiling point of the solvent to be used for the reaction. Although the reaction time varies depending on the reaction scale, reaction temperature and the like and is not constant, it can be properly selected from several minutes to 48 hours. After completion of the reaction, the target product is isolated from the reaction system containing the target product by means of a conventional method and purified as necessary through a recrystallization method, a method 58/150 distillation method, a column chromatography method and the like, to provide the target product. [0071] An arylalkyloxypyrimidine derivative represented by formula (II) is a new compound which is a synthetic intermediate useful for the production of an arylalkyloxypyrimidine derivative represented by formula (I). As the halogen atom represented by Hal, a chlorine atom and a bromine atom are preferable and a chlorine atom is more preferable. Production method of formula (I-1) from formula (II) [0072] This reaction is carried out according to the method described in J. Org. Chem., 1955, 20, 225 and the like. That is, an arylalkyloxypyrimidine derivative represented by formula (I-1) can be produced by catalytic hydrogenation of an arylalkyloxypyrimidine derivative represented by formula (II) in the presence of a base and a catalyst in an inert solvent under an atmosphere of hydrogen. Alternatively, it can be produced by generating hydrogen in the reaction system using formic acid instead of a hydrogen atmosphere. [0073] Examples of the catalyst that can be used for this reaction include tetrakis (triphenylphosphine) palladium, palladium-carbon, platinum, Raney nickel and the like. The amount of the catalyst to be used is about 0.0001 to 0.1 molar time with respect to the arylalkyloxypyrimidine derivative represented by formula (II). [0074] This reaction is carried out in the presence of a phase transfer catalyst (eg, quaternary ammonium salts, such as tetrabutylammonium bromide, benzyltriethylammonium bromide and the like), as needed. [0075] Examples of the base that can be used for this reaction include inorganic bases, such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate 59/150 sodium, sodium hydrogen carbonate, potassium hydrogen carbonate and the like, organic bases such as triethylamine, pyridine, sodium acetate, potassium acetate and the like and the like. The amount of the base to be used is, in general, about 0.5 to 10 molar times in relation to the arylalkyloxypyrimidine derivative represented by formula (II). [0076] Examples of the inert solvent that can be used for this reaction include alcohols, such as methanol, ethanol and the like, ethers, such as tetrahydrofuran, dioxane, dimethoxyethane (DME) and the like, amides, such as dimethylformamide, dimethylacetamide, N-methylpyrrolidone and the like, water and the like. These inert solvents can be used individually or a mixture of two or more types of them can be used. [0077] The reaction temperature in this reaction can generally be about 0 ° C up to the boiling point of the inert solvent to be used. Although the reaction time varies depending on the reaction scale, reaction temperature and the like and is not constant, it can be appropriately selected from several minutes to 48 hours. For production under a hydrogen atmosphere, the hydrogen pressure can be appropriately selected from the normal pressure up to 10 atm. When formic acid is used, the reaction is preferably carried out under an atmosphere of inert gas, such as nitrogen gas and argon gas. [0078] After completion of the reaction, the target substance can be isolated from the reaction system containing the target substance using a conventional method and the target substance can be produced by means of purification using recrystallization or column chromatography, etc., if required. Production method of formula (I) from formula (I-1) [0079] An arylalkyloxypyrimidine derivative represented by formula (I) can be produced by reacting an arylalkyloxypyrimidine derivative represented by formula (I-1) like an oxidan 60/150 t and in an inert solvent. Examples of the oxidant to be used in this reaction include manganese compounds, such as manganese dioxide and the like; chromates, such as sodium chromate and the like; lead compounds, such as lead tetraacetate and the like; mercury compounds, such as mercury oxide and the like; oxidants such as osmium tetroxide, ruthenium tetroxide, selenium dioxide and the like; metal halide agents, such as ferric chloride, copper iodide and the like; halogens, such as iodine, bromine and the like; palladium, such as palladium / carbon and the like; quinone oxidants, such as DDQ and the like; peroxides, such as hydrogen peroxide, perbenzoic acid, m-chloroperbenzoic acid and the like. Among these, aqueous hydrogen peroxide, perbenzoic acid and m-chloroperbenzoic acid are preferable. These oxidants can be appropriately selected from 0.8 to 10 molar times, preferably 1 to 2 molar times in relation to the arylalkyloxypyrimidine derivative represented by the formula (I-1). [0080] The inert solvent usable in the present reaction can be any one, as long as it does not significantly inhibit this reaction and, for example, cyclic ethers, such as diethyl ether, tetrahydrofuran, dioxane and the like; aromatic hydrocarbons, such as benzene, toluene, xylene and the like; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride and the like, halogenated aromatic hydrocarbons, such as chlorobenzene, dichlorobenzene and the like; nitriles, such as acetonitrile and the like; esters, such as ethyl acetate and the like; or organic acids, such as formic acid, acetic acid and the like; polar solvents, such as N, N-dimethylformamide, N, N-dimethylacetamide, 1,3-dimethyl-2-imidazolinone, water and the like can be mentioned. These inert solvents can be used individually or in a mixture of two or more types thereof. 61/150 [0081] The reaction temperature in this reaction can be appropriately selected from -30 ° C to the reflux temperature of the inert solvent to be used. Although the reaction time varies depending on the reaction scale and is not constant, it can be appropriately selected from several minutes to 48 hours. [0082] After completion of the reaction, the target substance can be isolated from the reaction system containing the target substance using a conventional method and the target substance can be produced by means of purification using recrystallization or column chromatography, etc., if required. [0083] Typical examples of the arylalkyloxypyrimidine derivative represented by formula (I) of the present invention are shown in Table 1 to Table 12, Table 14 and Table 15, to which the present invention is not limited. [0084] In the Tables, Me is a methyl group, Et is an ethyl group, Pr is a propyl group, Bu is a butyl group, Pen is a pentyl group, Hex is a hexyl group, Hep is a heptyl group, Oct is an octyl group, Ms is a methanesulfonyl group, Bn is a benzyl group, Ph is a phenyl group, THF is a tetrahydrofuranyl group, THP is a tetrahydropyranyl group, Py is a pyridyl group, TMS is a trimethyl group silyl, TBDMS is a tertiary butyldimethyl-silyl group, n- is normal, i- is iso, neo- is neo, s- is secondary, t- is tertiary, c- is an alicyclic hydrocarbon group and = c-Pr is a propylidene cycle group. The property shown is melting point (° C) or refractive index nD (measuring temperature; ° C). Table 13 shows the 1 H-NMR data of the compounds indicated with NMR in the property column in Tables 8, 9, 14 and 15. N ^ N (I-3) 62/150 Table 1 Comp. At the. R 1 (X) m Property value 1-1 Me 4-t-Bu 50-51 1-2 Et 4-t-Bu 1.3967 (21.8) 1-3 n-Pr 4-t-Bu 1.3268 (20.5) 1-4 i-Pr 4-t-Bu 49-50 1-5 c-Pr 4-t-Bu 1.5510 (21.3) 1-6 1,1-Me 2 -1-Pr 4-t-Bu1-7 n-Bu 4-t-Bu 1.5360 (27.5) 1-8 i-Bu 4-t-Bu 1.3067 (22.0) 1-9 s-Bu 4-t-Bu 1.4161 (17.0) 1-10 t-Bu 4-t-Bu1-11 CH2-c-Pr 4-t-Bu1-12 2-Me-1-Bu 4-t-Bu1-13 3-Me-1-Bu 4-t-Bu 1.3960 (21.1) 1-14 n-Pen 4-t-Bu 1.5230 (20.0) 1-15 2-Pen 4-t-Bu1-16 3-Pen 4-t-Bu1-17 neo-Pen 4-t-Bu1-18 2-Me-1-Pen 4-t-Bu1-19 3-Me-1-Pen 4-t-Bu1-20 4-Me-1-Pen 4-t-Bu1-21 c-Pen 4-t-Bu 48-49 1-22 n-Hex 4-t-Bu1-23 2-Hex 4-t-Bu1-24 3-Hex 4-t-Bu1-25 1-Me-1-Hex 4-t-Bu1-26 2-Me-1-Hex 4-t-Bu1-27 3-Me-1-Hex 4-t-Bu1-28 4-Me-1-Hex 4-t-Bu1-29 5-Me-1-Hex 4-t-Bu1-30 c-Hex 4-t-Bu 105-106 63/150 Table 1 (continued) Comp. At the. R 1 (X) m property value 1-31 n-Hep 4-t-Bu 1.3058 (20.5) 1-32 2-Hep 4-t-Bu1-33 3-Hep 4-t-Bu1-34 c-Hep 4-t-Bu1-35 n-Oct 4-t-Bu1-36 c-Oct 4-t-Bu1-37 CH = CH2 4-t-Bu 33-34 1-38 CH2CH = CH2 4-t-Bu1-39 CH2CHeCH 4-t-Bu1-40 CH2F 4-t-Bu 1.5229 (21.3) 1-41 CHF2 4-t-Bu1-42 CF3 4-t-Bu1-43 CH2CH2F 4-t-Bu1-44 CH2CHF2 4-t-Bu1-45 CH2CF3 4-t-Bu1-46 CF2CHF2 4-t-Bu1-47 CF2CF3 4-t-Bu1-48 CH2CH2CF3 4-t-Bu1-49 CH2CF2CF3 4-t-Bu1-50 CF2CF2CF3 4-t-Bu1-51 CN 4-t-Bu1-52 CHO 4-t-Bu 1.5590 (21.0) 1-53 CH = N-OH 4-t-Bu1-54 CH = N-OMe 4-t-Bu 54-55 1-55 CH = N-OEt 4-t-Bu 28-29 1-56 CH = N-O-c-Pr 4-t-Bu1-57 CH = N-O-i-Pr 4-t-Bu1-58 CH = N-OBn 4-t-Bu1-59 Eats 4-t-Bu1-60 CMe = N-OH 4-t-Bu 64/150 Table 1 (continued) Comp. At the. R 1 (X) m property value 1-61 CMe = N-OMe 4-t-Bu1-62 CMe = N-OEt 4-t-Bu1-63 CMe = N-O-c-Pr 4-t-Bu1-64 CMe = N-O-i-Pr 4-t-Bu1-65 CMe = N-OBn 4-t-Bu1-66 CH2OH 4-t-Bu1-67 CH2OMe 4-t-Bu1-68 CH2OEt 4-t-Bu1-69 CH2O-i-Pr 4-t-Bu1-70 CH2OPh 4-t-Bu 57-58 1-71 CH2O-2-F-Ph 4-t-Bu1-72 CH2OCH2OMe 4-t-Bu 1.5327 (20.5) 1-73 CH2SMe 4-t-Bu1-74 CH2SOMe 4-t-Bu1-75 CH2SO2Me 4-t-Bu1-76 CH2NMe2 4-t-Bu1-77 CHMeOH 4-t-Bu1-78 CHMeOMe 4-t-Bu1-79 CHMeOEt 4-t-Bu1-80 CHMeO-i-Pr 4-t-Bu1-81 CHMeOPh 4-t-Bu1-82 CHMeSMe 4-t-Bu1-83 CHMeSOMe 4-t-Bu1-84 CHMeSO2Me 4-t-Bu1-85 CHMeNMe2 4-t-Bu1-86 CO2H 4-t-Bu1-87 CO2Me 4-t-Bu1-88 CO2Et 4-t-Bu1-89 CO2-i-Pr 4-t-Bu1-90 CO2Ph 4-t-Bu 65/150 Table 1 (continued) Comp. At the. R 1 (X) m property value 1-91 KNOW ME 4-t-Bu1-92 CONMe2 4-t-Bu1-93 CONHEt 4-t-Bu1-94 CONEt2 4-t-Bu1-95 2-THF 4-t-Bu 1.5418 (25.8) 1-96 3-THF 4-t-Bu1-97 2-THP 4-t-Bu1-98 3-THP 4-t-Bu1-99 4-THP 4-t-Bu1-100 Ph 4-t-Bu 1.5535 (23.0) 1-101 2-Py 4-t-Bu1-102 3-Py 4-t-Bu1-103 4-Py 4-t-Bu1-104 2-thienyl 4-t-Bu1-105 3-thienyl 4-t-Bu1-106 2-furila 4-t-Bu1-107 3-furila 4-t-Bu1-108 CH2 (1,2,4-triazol-1-yl) 4-t-Bu1-109 CH 2 (pyrazol-1-yl) 4-t-Bu1-110 CH2O-TBDMS 4-t-Bu 1.5166 (22.0) N ^ N (I-3) 66/150 Table 2 Comp. At the. R 1 (X) m property value 2-1 Me 4-CF32-2 Et 4-CF3 1.4133 (21.6) 2-3 n-Pr 4-CF3 25 2-4 i-Pr 4-CF3 1.4027 (21.7) 2-5 c-Pr 4-CF3 55-57 2-6 1,1-Me 2 -1-Pr 4-CF32-7 n-Bu 4-CF3 1.4950 (27.5) 2-8 i-Bu 4-CF3 1.3546 (19.7) 2-9 s-Bu 4-CF3 1.3789 (20.0) 2-10 t-Bu 4-CF32-11 CH2-c-Pr 4-CF32-12 2-Me-1-Bu 4-CF32-13 3-Me-1-Bu 4-CF3 1.3315 (21.1) 2-14 n-Pen 4-CF3 1.4875 (20.0) 2-15 2-Pen 4-CF32-16 3-Pen 4-CF32-17 neo-Pen 4-CF32-18 2-Me-1-Pen 4-CF32-19 3-Me-1-Pen 4-CF32-20 4-Me-1-Pen 4-CF32-21 c-Pen 4-CF3 1.5092 (28.5) 2-22 n-Hex 4-CF32-23 2-Hex 4-CF32-24 3-Hex 4-CF32-25 1-Me-1-Hex 4-CF32-26 2-Me-1-Hex 4-CF32-27 3-Me-1-Hex 4-CF32-28 4-Me-1-Hex 4-CF32-29 5-Me-1-Hex 4-CF32-30 c-Hex 4-CF3 35-36 67/150 Table 2 (continued) Comp. At the. R 1 (X) m property value 2-31 n-Hep 4-CF3 1.3376 (19.2) 2-32 2-Hep 4-CF32-33 3-Hep 4-CF32-34 c-Hep 4-CF32-35 n-Oct 4-CF32-36 c-Oct 4-CF32-37 CH = CH2 4-CF3 56-57 2-38 CH2CH = CH2 4-CF32-39 CH2CHeCH 4-CF32-40 CH2F 4-CF32-41 CHF2 4-CF3 43-44 2-42 CF3 4-CF32-43 CH2CH2F 4-CF32-44 CH2CHF2 4-CF32-45 CH2CF3 4-CF32-46 CF2CHF2 4-CF32-47 CF2CF3 4-CF32-48 CH2CH2CF3 4-CF32-49 CH2CF2CF3 4-CF32-50 CF2CF2CF3 4-CF32-51 CN 4-CF3 54-56 2-52 CHO 4-CF3 38-39 2-53 CH = N-OH 4-CF32-54 CH = N-OMe 4-CF3 29-35 2-55 CH = N-OEt 4-CF3 1.5259 (21.5) 2-56 CH = N-O-c-Pr 4-CF32-57 CH = N-O-i-Pr 4-CF3 1.5194 (21.0) 2-58 CH = N-O-Bn 4-CF32-59 Eats 4-CF3 44-45 2-60 CMe = N-OH 4-CF3 68/150 Table 2 (continued) Comp. At the. R 1 (X) m property value 2-61 CMe = N-OMe 4-CF32-62 CMe = N-OEt 4-CF3 1.5142 (21.8) 2-63 CMe = N-O-c-Pr 4-CF32-64 CMe = N-O-i-Pr 4-CF32-65 CMe = N-OBn 4-CF32-66 CH2OH 4-CF3 90-91 2-67 CH2OMe 4-CF3 47-48 2-68 CH2OEt 4-CF32-69 CH2O-i-Pr 4-CF32-70 CH2OPh 4-CF32-71 CH2O-2-F-Ph 4-CF3 59-60 2-72 CH2OCH2OMe 4-CF32-73 CH2SMe 4-CF3 1.5368 (21.5) 2-74 CH2SOMe 4-CF3 83-84 2-75 CH2SO2Me 4-CF3 132-134 2-76 CH2NMe2 4-CF3 1.5047 (22.3) 2-77 CHMeOH 4-CF3 72-73 2-78 CHMeOMe 4-CF32-79 CHMeOEt 4-CF32-80 CHMeO-i-Pr 4-CF32-81 CHMeOPh 4-CF32-82 CHMeSMe 4-CF32-83 CHMeSOMe 4-CF32-84 CHMeSO2Me 4-CF32-85 CHMeNMe2 4-CF32-86 CO2H 4-CF3 144-146 2-87 CO2Me 4-CF3 103-105 2-88 CO2Et 4-CF3 97-98 2-89 CO2-i-Pr 4-CF32-90 CO2Ph 4-CF3 69/150 Table 2 (continued) Comp. At the. R 1 (X) m property value 2-91 KNOW ME 4-CF32-92 CONMe2 4-CF3 66-67 2-93 CONHEt 4-CF32-94 CONEt2 4-CF32-95 2-THF 4-CF3 1.5139 (26.8) 2-96 3-THF 4-CF32-97 2-THP 4-CF3 88-90 2-98 3-THP 4-CF32-99 4-THP 4-CF32-100 Ph 4-CF3 110-111 2-101 2-Py 4-CF32-102 3-Py 4-CF3 86-89 2-103 4-Py 4-CF3 88-92 2-104 2-thienyl 4-CF3 89-91 2-105 3-thienyl 4-CF3 68-70 2-106 2-furila 4-CF32-107 3-furila 4-CF3 65-67 2-108 CH2 (1,2,4-triazol-1-yl) 4-CF3 78-79 2-109 CH 2 (pyrazol-1-yl) 4-CF3 N ^ N (I-3) 70/150 Table 3 Comp. At the. R 1 (X) m property value 3-1 Me 4-OCF33-2 Et 4-OCF3 1.3982 (21.5) 3-3 n-Pr 4-OCF3 1.4876 (20.5) 3-4 i-Pr 4-OCF3 1.4167 (21.5) 3-5 c-Pr 4-OCF3 1.4986 (21.3) 3-6 1,1-Me 2 -1-Pr 4-OCF33-7 n-Bu 4-OCF3 1.4986 (28.7) 3-8 i-Bu 4-OCF3 1.4717 (19.5) 3-9 s-Bu 4-OCF3 1.3604 (19.9) 3-10 t-Bu 4-OCF33-11 CH2-c-Pr 4-OCF33-12 2-Me-1-Bu 4-OCF33-13 3-Me-1-Bu 4-OCF3 1.3862 (21.0) 3-14 n-Pen 4-OCF3 1.4914 (20.0) 3-15 2-Pen 4-OCF33-16 3-Pen 4-OCF33-17 neo-Pen 4-OCF33-18 2-Me-1-Pen 4-OCF33-19 3-Me-1-Pen 4-OCF33-20 4-Me-1-Pen 4-OCF33-21 c-Pen 4-OCF3 1.5105 (20.6) 3-22 n-Hex 4-OCF33-23 2-Hex 4-OCF33-24 3-Hex 4-OCF33-25 1-Me-1-Hex 4-OCF33-26 2-Me-1-Hex 4-OCF33-27 3-Me-1-Hex 4-OCF33-28 4-Me-1-Hex 4-OCF33-29 5-Me-1-Hex 4-OCF33-30 c-Hex 4-OCF3 71/150 Table 3 (continued) Comp. At the. R 1 (X) m property value 3-31 n-Hep 4-OCF3 1.3446 (19.5) 3-32 2-Hep 4-OCF33-33 3-Hep 4-OCF33-34 c-Hep 4-OCF33-35 n-Oct 4-OCF33-36 c-Oct 4-OCF33-37 CH = CH2 4-OCF3 1.4562 (21.2) 3-38 CH2CH = CH2 4-OCF33-39 CH2CHeCH 4-OCF33-40 CH2F 4-OCF33-41 CHF2 4-OCF33-42 CF3 4-OCF33-43 CH2CH2F 4-OCF33-44 CH2CHF2 4-OCF33-45 CH2CF3 4-OCF33-46 CF2CHF2 4-OCF33-47 CF2CF3 4-OCF33-48 CH2CH2CF3 4-OCF33-49 CH2CF2CF3 4-OCF33-50 CF2CF2CF3 4-OCF33-51 CN 4-OCF3 1.5156 (20.1) 3-52 CHO 4-OCF3 1.5089 (20.8) 3-53 CH = N-OH 4-OCF33-54 CH = N-OMe 4-OCF33-55 CH = N-OEt 4-OCF33-56 CH = N-O-c-Pr 4-OCF33-57 CH = N-O-i-Pr 4-OCF33-58 CH = N-O-Bn 4-OCF33-59 Eats 4-OCF33-60 CMe = N-OH 4-OCF3 72/150 Table 3 (continued) Comp. At the. R 1 (X) m property value 3-61 CMe = N-OMe 4-OCF33-62 CMe = N-OEt 4-OCF33-63 CMe = N-O-c-Pr 4-OCF33-64 CMe = N-O-i-Pr 4-OCF33-65 CMe = N-OBn 4-OCF33-66 CH2OH 4-OCF33-67 CH2OMe 4-OCF3 35-36 3-68 CH2OEt 4-OCF3 1.4932 (19.4) 3-69 CH2O-i-Pr 4-OCF33-70 CH2OPh 4-OCF33-71 CH2O-2-F-Ph 4-OCF33-72 CH2OCH2OMe 4-OCF33-73 CH2SMe 4-OCF33-74 CH2SOMe 4-OCF33-75 CH2SO2Me 4-OCF33-76 CH2NMe2 4-OCF33-77 CHMeOH 4-OCF33-78 CHMeOMe 4-OCF3 1.4922 (21.5) 3-79 CHMeOEt 4-OCF33-80 CHMeO-i-Pr 4-OCF33-81 CHMeOPh 4-OCF33-82 CHMeSMe 4-OCF33-83 CHMeSOMe 4-OCF33-84 CHMeSO2Me 4-OCF33-85 CHMeNMe2 4-OCF33-86 CO2H 4-OCF33-87 CO2Me 4-OCF33-88 CO2Et 4-OCF3 28-29 3-89 CO2-i-Pr 4-OCF33-90 CO2Ph 4-OCF3 73/150 Table 3 (continued) Comp. At the. R 1 (X) m property value 3-91 KNOW ME 4-OCF33-92 CONMe2 4-OCF33-93 CONHEt 4-OCF33-94 CONEt2 4-OCF33-95 2-THF 4-OCF3 1.5086 (25.8) 3-96 3-THF 4-OCF33-97 2-THP 4-OCF33-98 3-THP 4-OCF33-99 4-THP 4-OCF33-100 Ph 4-OCF33-101 2-Py 4-OCF33-102 3-Py 4-OCF33-103 4-Py 4-OCF33-104 2-thienyl 4-OCF33-105 3-thienyl 4-OCF33-106 2-furila 4-OCF33-107 3-furila 4-OCF33-108 CH2 (1,2,4-triazol-1-yl) 4-OCF33-109 CH 2 (pyrazol-1-yl) 4-OCF33-110 CH = N-OSO2Me 4-OCF3 107-111 3-111 AT THE 4-OCF3 51-52 N ^ N (I-3) 74/150 Table 4 Comp.At the. R 1 (X) m property value 4-1 1,3-dioxolan-2-yl 4-t-Bu 83-84 4-2 1,3-dioxolan-2-yl 4-O-i-Pr4-3 1,3-dioxolan-2-yl 4-TMS 68-69 4-4 1,3-dioxolan-2-yl 4-CF3 38-39 4-5 1,3-dioxolan-2-yl 4-OCF34-6 4,5-Me 2 -1,3-dioxolan (trans) -2-yl 4-t-Bu 59-60 4-7 4,5-Me 2 -1,3-dioxolan (trans) -2-yl 4-O-i-Pr4-8 4,5-Me 2 -1,3-dioxolan (trans) -2-yl 4-TMS4-9 4,5-Me 2 -1,3-dioxolan (trans) -2-yl 4-CF3 54-55 4-10 4,5-Me 2 -1,3-dioxolan (trans) -2-yl 4-OCF3 1.4965 (20.0) 4-11 4,5-Me 2 -1,3-dioxolan (cis) -2-yl 4-t-Bu4-12 4,5-Me 2 -1,3-dioxolan (cis) -2-yl 4-O-i-Pr4-13 4,5-Me 2 -1,3-dioxolan (cis) -2-yl 4-TMS4-14 4,5-Me 2 -1,3-dioxolan (cis) -2-yl 4-CF34-15 4,5-Me 2 -1,3-dioxolan (cis) -2-yl 4-OCF34-16 1,3-dioxan-2-yl 4-t-Bu 84-85 4-17 1,3-dioxan-2-yl 4-O-i-Pr 1.4238 (26.9) 4-18 1,3-dioxan-2-yl 4-TMS 70-71 4-19 1,3-dioxan-2-yl 4-CF3 105-106 4-20 1,3-dioxan-2-yl 4-OCF3 86-87 4-21 1,3-dioxan-2-yl 4-SCF3 122-123 4-22 1,3-dioxan-2-yl 4-Cl 84-85 4-23 5.5-Me 2 -1,3-dioxan-2-yl 4-t-Bu 61-62 4-24 5.5-Me 2 -1,3-dioxan-2-yl 4-O-i-Pr4-25 5.5-Me 2 -1,3-dioxan-2-yl 4-TMS4-26 5.5-Me 2 -1,3-dioxan-2-yl 4-CF3 114-115 4-27 5.5-Me 2 -1,3-dioxan-2-yl 4-OCF34-28 4,6-Me 2 -1,3-dioxan (trans) -2-yl 4-t-Bu 61-62 4-29 4,6-Me 2 -1,3-dioxan (trans) -2-yl 4-O-i-Pr4-30 4,6-Me 2 -1,3-dioxan (trans) -2-yl 4-TMS 75/150 Table 4 (continued) Comp. At the. R 1 (X) m property value 4-31 4,6-Me 2 -1,3-dioxan (trans) -2-yl 4-CF3 91-92 4-32 4,6-Me 2 -1,3-dioxan (trans) -2-yl 4-OCF34-33 4,6-Me 2 -1,3-dioxan (cis) -2-yl 4-t-Bu 68-69 4-34 4,6-Me 2 -1,3-dioxan (cis) -2-yl 4-O-i-Pr4-35 4,6-Me 2 -1,3-dioxan (cis) -2-yl 4-TMS4-36 4,6-Me 2 -1,3-dioxan (cis) -2-yl 4-CF3 148-149 4-37 4,6-Me 2 -1,3-dioxan (cis) -2-yl 4-OCF34-38 1,3-dioxepan-2-ila 4-t-Bu 75-76 4-39 1,3-dioxepan-2-ila 4-O-i-Pr4-40 1,3-dioxepan-2-ila 4-TMS 1.5406 (21.3) 4-41 1,3-dioxepan-2-ila 4-CF3 95-96 4-42 1,3-dioxepan-2-ila 4-OCF3 92-93 4-43 CH (OMe) 2 4-t-Bu 68-69 4-44 CH (OMe) 2 4-O-i-Pr 1.4255 (20.6) 4-45 CH (OMe) 2 4-TMS 1.5284 (21.3) 4-46 CH (OMe) 2 4-CF3 45-46 4-47 CH (OMe) 2 4-OCF3 30-31 4-48 CH (OEt) 2 4-t-Bu4-49 CH (OEt) 2 4-O-i-Pr4-50 CH (OEt) 2 4-TMS4-51 CH (OEt) 2 4-CF3 40-41 4-52 CH (OEt) 2 4-OCF3 1.4843 (21.9) 4-53 1,3-oxathiolan-2-yl 4-t-Bu 111-113 4-54 1,3-oxathiolan-2-yl 4-O-i-Pr4-55 1,3-oxathiolan-2-yl 4-TMS4-56 1,3-oxathiolan-2-yl 4-CF3 94-96 4-57 1,3-oxathiolan-2-yl 4-OCF3 86-88 4-58 oxazolidin-2-yl 4-t-Bu4-59 oxazolidin-2-yl 4-O-i-Pr4-60 oxazolidin-2-yl 4-TMS 76/150 Table 4 (continued) Comp. At the. R 1 (X) m property value 4-61 oxazolidin-2-yl 4-CF34-62 oxazolidin-2-yl 4-OCF34-63 1,3-dithiolan-2-yl 4-t-Bu 74-76 4-64 1,3-dithiolan-2-yl 4-O-i-Pr4-65 1,3-dithiolan-2-yl 4-TMS4-66 1,3-dithiolan-2-yl 4-CF3 88-89 4-67 1,3-dithiolan-2-yl 4-OCF3 72-73 4-68 1,3-ditian-2-ila 4-t-Bu 123-125 4-69 1,3-ditian-2-ila 4-O-i-Pr4-70 1,3-ditian-2-ila 4-TMS4-71 1,3-ditian-2-ila 4-CF3 124-126 4-72 1,3-ditian-2-ila 4-OCF3 116-117 4-73 imidazolidin-2-yl 4-t-Bu4-74 imidazolidin-2-yl 4-O-i-Pr4-75 imidazolidin-2-yl 4-TMS4-76 imidazolidin-2-yl 4-CF34-77 imidazolidin-2-yl 4-OCF34-78 CH (SMe) 2 4-t-Bu 1.3999 (20.8) 4-79 CH (SMe) 2 4-O-i-Pr4-80 CH (SMe) 2 4-TMS4-81 CH (SMe) 2 4-CF3 73-74 4-82 CH (SMe) 2 4-OCF3 1.4826 (21.0) 4-83 CH (SEt) 2 4-t-Bu 1.4209 (20.7) 4-84 CH (SEt) 2 4-O-i-Pr4-85 CH (SEt) 2 4-TMS4-86 CH (SEt) 2 4-CF3 1.3869 (20.6) 4-87 CH (SEt) 2 4-OCF3 1.3941 (20.6) 4-88 CH (OMe) (1,2,4-triazol-1-yl) 4-CF3 83-84 4-89 CH (OMe) (pyrazol-1-yl) 4-CF3 41-42 77/150 Table 4 (continued) Comp. At the. R 1 (X) m property value 4-90 jK> 4-CF3 75-76 4-91 / Q 4-CF3 67-68 R 2 R 3 (X) m (I-1) Table 5 (q = 1, Y = CH) Comp. At the. R 1 R 2 R 3 (X) m property value 5-1 c-Hex CF3 H H 1.5400 (21.0) 5-2 c-Hex CF3 H 4-t-Bu 1.4491 (21.0) 5-3 c-Hex H H 4-SCF3 73-74 N ^ N (I-3) Table 6 Comp. At the. R 1 (X) m property value 6-1 Me 4-O-i-Pr6-2 Et 4-O-i-Pr6-3 n-Pr 4-O-i-Pr6-4 i-Pr 4-O-i-Pr6-5 c-Pr 4-O-i-Pr6-6 1,1-Me 2 -1-Pr 4-O-i-Pr6-7 n-Bu 4-O-i-Pr6-8 i-Bu 4-O-i-Pr6-9 s-Bu 4-O-i-Pr 78/150 Comp. At the. R 1 (X) m property value 6-10 t-Bu 4-O-i-Pr6-11 CH2-c-Pr 4-O-i-Pr6-12 2-Me-1-Bu 4-O-i-Pr6-13 3-Me-1-Bu 4-O-i-Pr6-14 n-Pen 4-O-i-Pr6-15 2-Pen 4-O-i-Pr6-16 3-Pen 4-O-i-Pr6-17 neo-Pen 4-O-i-Pr6-18 2-Me-1-Pen 4-O-i-Pr6-19 3-Me-1-Pen 4-O-i-Pr6-20 4-Me-1-Pen 4-O-i-Pr6-21 c-Pen 4-O-i-Pr6-22 n-Hex 4-O-i-Pr6-23 2-Hex 4-O-i-Pr6-24 3-Hex 4-O-i-Pr6-25 1-Me-1-Hex 4-O-i-Pr6-26 2-Me-1-Hex 4-O-i-Pr6-27 3-Me-1-Hex 4-O-i-Pr6-28 4-Me-1-Hex 4-O-i-Pr6-29 5-Me-1-Hex 4-O-i-Pr6-30 c-Hex 4-O-i-Pr6-31 n-Hep 4-O-i-Pr6-32 2-Hep 4-O-i-Pr6-33 3-Hep 4-O-i-Pr6-34 c-Hep 4-O-i-Pr6-35 n-Oct 4-O-i-Pr6-36 c-Oct 4-O-i-Pr6-37 CH = CH2 4-O-i-Pr6-38 CH2CH = CH2 4-O-i-Pr6-39 CH2CHeCH 4-O-i-Pr6-40 CH2F 4-O-i-Pr 79/150 Table 6 (continued) Comp. At the. R 1 (X) m property value 6-41 CHF2 4-O-i-Pr6-42 CF3 4-O-i-Pr6-43 CH2CH2F 4-O-i-Pr6-44 CH2CHF2 4-O-i-Pr6-45 CH2CF3 4-O-i-Pr6-46 CF2CHF2 4-O-i-Pr6-47 CF2CF3 4-O-i-Pr6-48 CH2CH2CF3 4-O-i-Pr6-49 CH2CF2CF3 4-O-i-Pr6-50 CF2CF2CF3 4-O-i-Pr6-51 CN 4-O-i-Pr6-52 CHO 4-O-i-Pr6-53 CH = N-OH 4-O-i-Pr6-54 CH = N-OMe 4-O-i-Pr6-55 CH = N-OEt 4-O-i-Pr6-56 CH = N-O-c-Pr 4-O-i-Pr6-57 CH = N-O-i-Pr 4-O-i-Pr6-58 CH = N-OBn 4-O-i-Pr6-59 Eats 4-O-i-Pr6-60 CMe = N-OH 4-O-i-Pr6-61 CMe = N-OMe 4-O-i-Pr6-62 CMe = N-OEt 4-O-i-Pr6-63 CMe = N-O-c-Pr 4-O-i-Pr6-64 CMe = N-O-i-Pr 4-O-i-Pr6-65 CMe = N-OBn 4-O-i-Pr6-66 CH2OH 4-O-i-Pr6-67 CH2OMe 4-O-i-Pr6-68 CH2OEt 4-O-i-Pr6-69 CH2O-i-Pr 4-O-i-Pr6-70 CH2OPh 4-O-i-Pr Table 6 (continued) 80/150 Comp. At the. R 1 (X) m property value 6-71 CH2O-2-F-Ph 4-O-i-Pr6-72 CH2OCH2OMe 4-O-i-Pr6-73 CH2SMe 4-O-i-Pr6-74 CH2SOMe 4-O-i-Pr6-75 CH2SO2Me 4-O-i-Pr6-76 CH2NMe2 4-O-i-Pr6-77 CHMeOH 4-O-i-Pr6-78 CHMeOMe 4-O-i-Pr6-79 CHMeOEt 4-O-i-Pr6-80 CHMeO-i-Pr 4-O-i-Pr6-81 CHMeOPh 4-O-i-Pr6-82 CHMeSMe 4-O-i-Pr6-83 CHMeSOMe 4-O-i-Pr6-84 CHMeSO2Me 4-O-i-Pr6-85 CHMeNMe2 4-O-i-Pr6-86 CO2H 4-O-i-Pr6-87 CO2Me 4-O-i-Pr6-88 CO2Et 4-O-i-Pr6-89 CO2-i-Pr 4-O-i-Pr6-90 CO2Ph 4-O-i-Pr6-91 KNOW ME 4-O-i-Pr6-92 CONMe2 4-O-i-Pr6-93 CONHEt 4-O-i-Pr6-94 CONEt2 4-O-i-Pr6-95 2-THF 4-O-i-Pr6-96 3-THF 4-O-i-Pr6-97 2-THP 4-O-i-Pr6-98 3-THP 4-O-i-Pr6-99 4-THP 4-O-i-Pr6-100 Ph 4-O-i-Pr 81/150 Table 6 (continued) Comp. At the. R 1 (X) m property value 6-101 2-Py 4-O-i-Pr6-102 3-Py 4-O-i-Pr6-103 4-Py 4-O-i-Pr6-104 2-thienyl 4-O-i-Pr6-105 3-thienyl 4-O-i-Pr6-106 2-furila 4-O-i-Pr6-107 3-furila 4-O-i-Pr6-108 CH 2 (1,2,4-triazol-1-yl) 4-O-i-Pr6-109 CH 2 (pyrazol-1-yl) 4-O-i-Pr N ^ N (I-3) Table 7 Comp. At the. R 1 (X) m property value 7-1 Me 4-TMS7-2 Et 4-TMS7-3 n-Pr 4-TMS7-4 i-Pr 4-TMS7-5 c-Pr 4-TMS7-6 1,1-Me 2 -1-n-Pr 4-TMS7-7 n-Bu 4-TMS7-8 i-Bu 4-TMS7-9 s-Bu 4-TMS7-10 t-Bu 4-TMS7-11 CH2-c-Pr 4-TMS7-12 2-Me-1- n-Bu 4-TMS7-13 3-Me-1- n-Bu 4-TMS7-14 n-Pen 4-TMS7-15 2-Pen 4-TMS 82/150 Table 7 (continued) Comp. At the. R 1 (X) m property value 7-16 3-Pen 4-TMS7-17 neo-Pen 4-TMS7-18 2-Me-1- n-Pen 4-TMS7-19 3-Me-1- n-Pen 4-TMS7-20 4-Me-1- n-Pen 4-TMS7-21 c-Pen 4-TMS7-22 n-Hex 4-TMS7-23 2-Hex 4-TMS7-24 3-Hex 4-TMS7-25 1-Me-1- n-Hex 4-TMS7-26 2-Me-1- n-Hex 4-TMS7-27 3-Me-1- n-Hex 4-TMS7-28 4-Me-1- n-Hex 4-TMS7-29 5-Me-1- n-Hex 4-TMS7-30 c-Hex 4-TMS7-31 n-Hep 4-TMS7-32 2-Hep 4-TMS7-33 3-Hep 4-TMS7-34 c-Hep 4-TMS7-35 n-Oct 4-TMS7-36 c-Oct 4-TMS7-37 CH = CH2 4-TMS7-38 CH2CH = CH2 4-TMS7-39 CH2CHeCH 4-TMS7-40 CH2F 4-TMS7-41 CHF2 4-TMS7-42 CF3 4-TMS7-43 CH2CH2F 4-TMS7-44 CH2CHF2 4-TMS7-45 CH2CF3 4-TMS 83/150 Table 7 (continued) Comp. At the. R 1 (X) m property value 7-46 CF2CHF2 4-TMS7-47 CF2CF3 4-TMS7-48 CH2CH2CF3 4-TMS7-49 CH2CF2CF3 4-TMS7-50 CF2CF2CF3 4-TMS7-51 CN 4-TMS7-52 CHO 4-TMS 1.5488 (21.3) 7-53 CH = N-OH 4-TMS7-54 CH = N-OMe 4-TMS7-55 CH = N-OEt 4-TMS7-56 CH = N-O-c-Pr 4-TMS7-57 CH = N-O-i-Pr 4-TMS7-58 CH = N-OBn 4-TMS7-59 Eats 4-TMS7-60 CMe = N-OH 4-TMS7-61 CMe = N-OMe 4-TMS7-62 CMe = N-OEt 4-TMS7-63 CMe = N-O-c-Pr 4-TMS7-64 CMe = N-O-i-Pr 4-TMS7-65 CMe = N-OBn 4-TMS7-66 CH2OH 4-TMS 70-71 7-67 CH2OMe 4-TMS7-68 CH2OEt 4-TMS7-69 CH2O-i-Pr 4-TMS7-70 CH2OPh 4-TMS7-71 CH2O-2-F-Ph 4-TMS7-72 CH2OCH2OMe 4-TMS7-73 CH2SMe 4-TMS7-74 CH2SOMe 4-TMS7-75 CH2SO2Me 4-TMS 84/150 Table 7 (continued) Comp. At the. R 1 (X) m property value 7-76 CH2NMe2 4-TMS7-77 CHMeOH 4-TMS7-78 CHMeOMe 4-TMS7-79 CHMeOEt 4-TMS7-80 CHMeO-i-Pr 4-TMS7-81 CHMeOPh 4-TMS7-82 CHMeSMe 4-TMS7-83 CHMeSOMe 4-TMS7-84 CHMeSO2Me 4-TMS7-85 CHMeNMe2 4-TMS7-86 CO2H 4-TMS7-87 CO2Me 4-TMS7-88 CO2Et 4-TMS7-89 CO2-i-Pr 4-TMS7-90 CO2Ph 4-TMS7-91 KNOW ME 4-TMS7-92 CONMe2 4-TMS7-93 CONHEt 4-TMS7-94 CONEt2 4-TMS7-95 2-THF 4-TMS7-96 3-THF 4-TMS7-97 2-THP 4-TMS7-98 3-THP 4-TMS7-99 4-THP 4-TMS7-100 Ph 4-TMS7-101 2-Py 4-TMS7-102 3-Py 4-TMS7-103 4-Py 4-TMS7-104 2-thienyl 4-TMS7-105 3-thienyl 4-TMS 85/150 Table 7 (continued) Comp. At the. R 1 (X) m property value 7-106 2-furila 4-TMS7-107 3-furila 4-TMS7-108 CH2 (1,2,4-triazol-l-yl) 4-TMS7-109 CH 2 (pyrazol-1-yl) 4-TMS N ^ N (I-3) Table 8 Comp. At the. R 1 (X) m property value 8-1 CH2Ph 4-CF3 47-48 8-2 CH2Ph 4-t-Bu 1.5658 (20.1) 8-3 CH2Ph 4-OCF3 1.5374 (20.1) 8-4 CH = N-OSO2Me 4-OCF3 107-111 8-5 CH = N-OCH2CeCH 4-CF3 47-49 8-6 CH = N-O-i-Bu 4-CF3 1.5166 (21.0) 8-7 n-Pr 4-SCF3 30-31 8-8 n-Pr 4-Cl 1.3476 (21.2) 8-9 CMe = N-OEt 4-CF3 1.5096 (21.8) 8-10 CH = N-3-Py 4-t-Bu NMR 8-11 CONHCH2CF3 4-t-Bu 32-33 8-12 CH = CH2 4-Cl 40-42 8-13 CONHCH2CF3 4-CF3 94-96 8-14 i-Bu 2,4-Cl2 1.3916 (19.4) 8-15 CH2CH2SPh 4-CF3 76-77 8-16 CH2CH2SOPh 4-CF3 85-86 8-17 CH2CH2SO2Ph 4-CF3 98-99 8-18 CeCTMS 4-CF3 82-83 8-19 CeCH 4-CF3 120-121 8-20 CH2CH2OEt 4-t-Bu 1.3662 (21.5) 86/150 Table 8 (continued) Comp. At the. R 1 (X) m property value 8-21 CONHPh 4-CF3 158-159 8-22 2-F-Ph 4-CF3 120-122 8-23 CH2CH2OEt 4-CF3 1.4067 (19.9) 8-24 CH2CH2OEt 4-OCF3 1.3869 (19.8) 8-25 CH (OH) CH2OH 4-t-Bu 1.3494 (21.2) 8-26 CH2CH2OMe 4-t-Bu 1.3577 (21.5) 8-27 CH2CH2OMe 4-CF3 1.3899 (21.4) 8-28 CH2CH2OMe 4-OCF3 1.6777 (21.3) 8-29 CECCH2OMe 4-CF3 52-54 8-304-t-Bu 1.3329 (21.1) 8-31 CH2CH2CH2Cl 4-OCF3 1.4369 (21.0) 8-32 CECMe 4-CF3 84-85 8-33 CECCMe2OH 4-CF3 121-122 8-34 x ° 4-CF3 68-70 8-35 N-Me-pyrazol-4-yl 4-CF3 101-103 8-36 CeCCH2OH 4-CF3 98-100 8-37 CH2CH2CH2Cl 4-t-Bu 1.4169 (20.8) 8-38 CH (OH) CH2OCMe2OMe 4-t-Bu 1.3542 (24.3) 8-39 CeCCH2F 4-CF3 66-69 8-40 CONHCH2CH2OH 4-CF3 86-89 8-41 CH (OH) CH2OH 4-CF3 102-104 8-42 CH (OMe) CH2OMe 4-CF3 1.3546 (20.7) 8-43 CH (OEt) CH2OEt 4-CF3 1.3627 (20.7) 8-44 CH (OH) CH2OEt 4-CF3 1.3039 (20.6) 8-45 CH2NHCOMe 4-CF3 134-135 87/150 Table 8 (continued) Comp.At the. R 1 (X) m property value 8-46 AT THE> = O • r ^ N H 4-t-Bu 207-208 8-47 CHBrCH2Br 4-CF3 118-120 8-48 Λ> - 4-CF3 1.2996 (23.6) 8-49 CH = C (CO2Me) 2 4-OCF3 1.4840 (22.6) 8-50 ON, / O- Cl 4-CF3 96-97 8-51 CH (OMs) CH2OMs 4-CF3 1.3084 (22.8) 8-52 CH2CH2SMe 4-CF3 1.3713 (25.6) 8-53 CH2NHMe 4-TMS 1.5327 (22.7) 8-54 CMe2OH 4-CF3 90-91 8-55 CH2CH2SOMe 4-CF3 1.3600 (25.7) 8-56 CH2CH2SO2Me 4-CF3 88-89 8-57 O-N 4-CF3 1.3243 (25.5) 8-58 Et 4- (4-OCF3-Ph) 1.3208 (26.4) 8-59 3-F-Ph 4-CF3 99-100 8-60 4-F-Ph 4-CF3 59-61 8-61 oxiranil 4-CF3 1.3405 (23.7) 8-62 CH (OCH2OMe) CH2OCH2OMe 4-CF3 1.3199 (23.6) 8-63 CMe 2 OMe 4-CF3 78-79 8-64 CEC-n-Pr 4-CF3 32-34 88/150 N ^ N (I-3) Table 9 Comp. At the. R 1 (X) m property value 9-1 1,3-dioxan-2-yl 4-i-Bu 78-79 9-2 1,3-dioxan-2-yl 4-s-Bu NMR 9-3 1,3-dioxan-2-yl 2-F-4-CF3 121-122 9-4 1,3-dioxan-2-yl 4-OCF2CF2H 87-88 9-5 1,3-ditian-2-ila 4-CN 154-158 9-6 1,3-ditian-2-ila 4-NO2 162-171 9-7 imidazolin-2-ila 4-OCF3 104-105 9-8 1,3-dioxan-2-yl 3-Cl-4-i-Pr 1.3783 (20.7) 9-9 1,3-oxatian-2-yl 4-t-Bu 102-104 9-10 1,3-oxatian-2-yl 4-CF3 125-126 9-11 1,3-oxatian-2-yl 4-OCF3 118-120 9-12 OO-OS— 'Oo 4-t-Bu 212-215 9-13 OO-OS— 'Oo 4-CF3 226-230 9-14 OOSS-Ν 'Oo 4-OCF3 227-231 9-15 . OO 4-t-Bu 125-126 9-164-OCF3 86-89 9-17 O O 4-t-Bu 139-140 89/150 Table 9 (continued) Comp. At the. R 1 (X) m property valuedade 9-18 2,2-dimethyl-1,3-dioxolan-4-yl 4-t-Bu 1.3345 (24.4) 9-19 tiazolin-2-ila 4-CF3 91-92 9-20 1,3-dioxolan-2-yl 2-F-4-CF3 48-50 9-21 1,3-dioxepan-2-ila 2-F-4-CF3 114-115 9-224-CF3 109-110 9-234-CF3 158-160 9-24 IIO 4-t-Bu 97-100 9-25 THEREII O 4-CF3 155-177 9-26 THEREII O 4-OCF3 171-182 9-27 THEREA, O O 4-CF3 205-206 9-28 THEOo 4-OCF3 194-195 9-29 F ^ N-, AA O 4-OCF3 1.5117 (22.4) 9-30 1,3-dimethylimidazolidin-2-yl 4-OCF3 1.5084 (22.3) 90/150 Table 9 (continued) Comp. At the. R 1 (X) m property value 9-31 4-ethyl-1,3-dioxolan-2-yl 4-CF3 32-33 9-32 4-methyl-1,3-dioxan-2-yl 4-CF3 98-100 9-334-CF3 67-69 9-34 1,1- (OMe) 2 Et 4-CF3 120-122 9-35 1 - (2-Me-1,3-dioxolan-2-yl) 4-CF3 64-65 9-36 1 - (2-Me-1,3-dioxan-2-yl) 4-CF3 89-90 9-37 The Λ> ο 4-OCF3 119-121 9-38 4-methyl-1,3-dioxan-2-yl 4-CF3 112-120 9-39 2,2-dimethyl-1,3-dioxolan-4-yl 4-CF3 1.3314 (22.5) 9-404-t-Bu 1.4558 (27.2) 9-41 oP 4-CF3 1.4058 (25.8) 9-42 1,3-dioxan-2-yl 4-i-Pr 63-68 9-43 1,3-dioxan-2-yl 4-OCH2CF3 103-105 9-44 4-n-Pr-1,3-dioxolan-2-yl 4-CF3 1.3655 (26.8) 9-45 4-Me-1,3-dioxolan-2-yl 4-CF3 68-72 9-464-CF3 173-174 9-47 O V ° rd 0 • Ρ'ο H 4-CF3 140-145 91/150 O. N ^ N SVa R 1 (X) m (I-4) Table 10 Comp. At the. R 1 (X) m property value 10-1 n-Bu 4-OCF3 99-101 10-2 1,3-dioxan-2-yl 4-OCF3 145-147 10-3 3-Me-n-Bu 4-OCF3 88-99 10-4 n-Pr 4-OCF3 86-87 10-5 n-Pr 4-CF3 128-129 10-6 n-Pr 4-t-Bu 54-55 10-7 Et 4-t-Bu 143-144 10-8 Et 4-OCF3 97-98 10-9 i-Pr 4-OCF3 111-112 10-10 CH = CH2 4-CF3 136-139 10-11 i-Bu 4-t-Bu 106 N ^ N R 1 (I-5) Table 11 Comp. At the. R 1 Z property value 11-1 1,3-dioxan-2-yl OCF 3 55-56 11-2 n-Pr / = N* ^ CF3 1.3420 (23.6) 11-3 1,3-dioxan-2-yl *) OCF 45-46 92/150 Table 11 Comp. At the. R 1 Z property value 11-4 1,3-dioxan-2-yl * A ^ _ CD _CF 3 69-71 11-5 n-Pr / = N /% / C 29-30 11-6 1,3-dioxan-2-yl / = N/ - \ /> - o^ CF3 83-84 N ^ NR 2 R 3 Hal (X) m Y (II) Table 12 (Hal = Cl, R 2 , R 3 = H, q = 1, Y = CH) Comp. At the. R 1 (X) m property value 12-1 1,3-dioxolan-2-yl 4-t-Bu 109-110 12-2 1,3-dioxolan-2-yl 4-TMS 104-105 12-3 1,3-dithiolan-2-yl 4-t-Bu 95-102 12-4 1,3-dithiolan-2-yl 4-CF3 79-81 12-5 1,3-dithiolan-2-yl 4-OCF3 65-70 12-6 1,3-oxatian-2-yl 4-t-Bu 121-122 12-7 1,3-oxatian-2-yl 4-CF3 88-90 12-8 1,3-oxatian-2-yl 4-OCF3 61-62 12-9 1,3-dioxan-2-yl 4-i-Bu 1.3962 (18.0) 12-10 1,3-dioxan-2-yl 2-F-4-CF3 113-115 12-11 1,3-dioxan-2-yl 4-OCF2CF2H 105-106 12-12 1,3-dioxan-2-yl 4-OCF3 65-72 12-13 1,3-ditian-2-ila 4-OCF3 103-111 12-14 1,3-ditian-2-ila 4-CN 138-141 12-15 1,3-ditian-2-ila 4-NO2 147-150 93/150 Table 12 (Hal = Cl, R 2 , R 3 = H, q = 1, Y = CH) Comp. At the. R 1 (X) m property value 12-16 1,3-ditian-2-ila 4-t-Bu 149-153 12-17 1,3-ditian-2-ila 4-CF3 114-122 12-18 1,3-oxatian-2-yl 4-t-Bu 98-100 12-19 1,3-oxatian-2-yl 4-CF3 118-119 12-20 1,3-oxatian-2-yl 4-OCF3 98 12-21 CH (SEt) 2 4-t-Bu 1.4087 (21.3) 12-22 CH (SEt) 2 4-CF3 1.4541 (21.3) 12-23 CH (SEt) 2 4-OCF3 1.4326 (21.3) 12-24 CH (SMe) 2 4-t-Bu 91-95 12-25 CH (SMe) 2 4-CF3 77-79 12-26 CH (SMe) 2 4-OCF3 51-54 12-27 CHO 4-CF3 64-66 12-28 CH = N-OH 4-CF3 182-184 Table 13 - NMR data Comp. At the. 'H-NMR data 8-10 9.24 (1H, s), 8.89 (1H, s), 8.74 (1H, s), 8.51-8.47 (1H, s), 7.57-7.50 (1H, m), 7.46-7.39 (4H, m), 7.35-7.30 (1H, m), 5.54 (2H, s), 1.33 (9H, s) 9-2 8.76 (1H, s), 8.72 (1H, s), 7.22-7.17 (2H, m), 7.38-7.34 (2H, m),5.77 (1H, s), 5.46 (2H, s), 4.28-4.21 (2H, m), 4.02-3.93 (2H, m),2.61 (1H, tq), 2.31-2.17 (1H, m), 1.60 (dq, 2H), 1.48-1.41 (1H, m), 1.24 (3H, d), 0.84 (3H, t) 14-7 8.73 (1H, s), 8.68 (1H, d), 7.64 (2H, d), 7.54 (2H, d), 5.53 (2H, dd), 5.10-5 .07 (1H, m), 4.75-4.68 (1H, m), 3.61-3.34 (4H, m), 1.32-1.24 (3H, m), 1.18 -1.17 (3H, m) 14-8 8.73 (1H, s), 8.68 (1H, d), 7.64 (2H, d), 7.54 (2H, d), 5.53 (2H, dd), 5.10-5 , 07 (1H, m), 4.40-4.37 (1H, m), 3.88-3.84 (1H, m), 3.59-3.49 (1H, m), 3.27 (3H, d), 1.63-1.53 (2H, t), 1.26-1.24 (1H, br), 0.89 (3H, q) 94/150 Table 13 (continued) Comp.At the. 1 H-NMR data 14-9 9.28 (1H, s), 8.93 (1H, s), 8.00 (1H, s), 7.71-7.66 (2H, m), 7.60-7.55 (2H, m), 5.62 (2H, s) 14-12 8.61 (1H, s), 8.50 (1H, s), 7.65 (2H, d), 7.56 (2H, d), 6.51-6.38(2H, m), 5.55 (2H, s), 2.30-2.23 (2H, m), 1.10 (3H, t) 14-13 8.64 (1H, s), 8.51 (1H, s), 7.65 (2H, d), 7.57 (2H, d), 6.53-6.40 (1H, m), 6 , 49 (1H, d), 5.56 (2H, s), 3.63 (2H, t), 2.71 (2H, dd) 14-15 8.71 (1H, s), 8.60 (1H, s), 7.64 (2H, d), 7.55 (2H, d), 6.75 (1H, d),5.91 (1H, dd), 5.52 (2H, s), 5.37 (1H, d), 4.08-4.05 (2H, m), 3,933.90 (2H, m) 14-17 8.65 (1H, s), 8.32 (1H, s), 7.64 (2H, d), 7.56 (2H, d), 5.53 (2H, s),4.90 (1H, t), 3.97-3.95 (2H, m), 3.87-3.85 (2H, m), 2.74 (2H, dd), 2.00-1, 96 (2H, m) 14-19 8.93 (1H, s), 8.77 (1H, s), 7.66 (2H, d), 7.53 (2H, d), 5.62 (2H,dd), 5.55 (1H, d), 1.55-1.48 (1H, m), 0.90-0.78 (2H, m), 0.70-0.64 (1H, m) , 0.47-0.41 (1H, m) 14-28 9.01 (1H, s), 8.84 (1H, s), 7.66 (2H, d), 7.52 (2H, d), 5.63 (2H, s),5.32 (1H, d), 3.72 (3H, s), 2.89 (1H, dd), 2.69 (1H, dd), 1.75 (1H, br) 14-45 8.66 (1H, s), 8.43 (1H, s), 7.66 (2H, d), 7.55 (2H, d), 5.51 (2H, s),2.50 (2H, d), 1.03-1.00 (1H, m), 0.57-0.55 (2H, m), 0.20 (2H, dd) 14-54 8.81 (1H, s), 8.68 (1H, s), 7.69-7.63 (2H, m), 7.55-7.50 (2H, m), 5.61 (1H, d), 5.48 (1H, d), 4.98 (1H, q), 3.49 (3H, s) 14-56 8.70 (1H, s), 8.35 (1H, s), 7.63 (2H, d), 7.50 (2H, d), 5.56 (2H, s), 3.57 (3H , s), 1.68 (2H, dd), 1.15 (2H, dd) 14-60 8.71 (1H, s), 8.55 (1H, s), 7.64 (2H, d), 7.55 (2H, d), 5.53(2H, s), 4.51 (2H, s), 3.72 (1H, sep), 1.23 (6H, d) 14-68 9.30 (1H, s), 8.87 (1H, s), 7.73-7.68 (2H, m), 7.63-7.57 (2H, m), 7.35-7, 24 (1H, m), 5.65 (2H, s), 4.29-4.16 (1H, m), 1.15 (6H, d) 95/150 Table 13 (continued) Comp.At the. 1 H-NMR data 14-69 9.29 (1H, s), 8.86 (1H, s), 7.73-7.68 (2H, m), 7.64-7.58 (2H, m), 7.40-7, 30 (1H, br), 5.61 (2H, s), 1.33 (9H, s) 14-70 9.31 (1H, s), 8.87 (1H, s), 7.74-7.68 (2H, m), 7.64-7.58 (2H, m), 7.39 (1H, d), 5.64 (2H, s), 4.05-3.94 (1H, m), 1.90-1.81 (2H, m), 1.48-1.42 (3H, m) , 1.42-1.29 (2H, m), 1.21-1.08 (3H, m) 14-71 8.80 (1H, s), 8.54 (1H, s), 7.67-7.60 (2H, m), 7.57-7.50 (2H, m), 5.58 (2H, s), 3.65 (2H, t), 3.24 (2H, t), 2.20-1.91 (2H, m), 1.91-1.83 (2H, m) 14-72 8.82 (1H, s), 8.54 (1H, s), 7.67-7.62 (2H, m), 7.57-7.52 (2H, m), 5.57 (2H, s), 3.82-3.77 (2H, m), 3.75-3.70 (2H, m), 3.563.50 (2H, m), 3.27-3.21 (2H, m) 14-73 9.22 (1H, s), 8.77 (1H, s), 7.94-7.83 (2H, m), 7.62-7.57 (2H, m), 7.57-7, 51 (2H, m), 5.58 (2H, s), 3.42 (2H, q), 2.33 (2H, t), 2.01 (6H, s) 14-74 9.33 (1H, s), 8.87 (1H, s), 7.97-7.86 (1H, br), 7.62-7.56 (2H, m), 7.52-7, 46 (2H, m), 7.40-7.35 (1H, m), 7.33-7.27 (1H, m), 7.26-7.16 (2H, m), 5.60 ( 2H, s), 4.65 (2H, d) 14-75 9.34 (1H, s), 8.89 (1H, s), 7.80-7.65 (1H, br), 7.60-7.54 (2H, m), 7.46-7, 41 (2H, m), 7.30-7.27 (3H, m), 7.12-7.06 (1H, m), 5.61 (2H, s), 4.56 (2H, d) 14-76 9.34 (1H, s), 8.89 (1H, s), 7.74-7.64 (1H, br), 7.60-7.54 (2H, m), 7.44-7, 39 (2H, m), 7.29-7.23 (2H, m), 7.17-7.12 (2H, m), 5.60 (2H, s), 4.56 (2H, d) 96/150 Table 13 (continued) Comp. At the. 'H-NMR data 14-77 9.25 (1H, s), 8.76 (1H, s), 7.83-7.73 (1H, br), 7.50-7.44 (2H, m), 7.38-7, 32 (2H, m), 7.23-7.14 (2H, m), 6.84-6.78 (1H, m), 6.73-6.68 (1H, m), 5.53 ( 2H, s), 4.52 (2H, d), 3.51 (3H, s) 14-78 9.35 (1H, s), 8.88 (1H, s), 7.76-7.65 (1H, br), 7.56-7.50 (2H, m), 7.42-7, 36 (2H, m), 7.23-7.17 (1H, m), 6.87-6.82 (1H, m), 6.81-6.77 (2H, m), 5.59 ( 2H, s), 4.56 (2H, d), 3.77 (3H, s) 14-79 9.35 (1H, s), 8.87 (1H, s), 7.67-7.59 (1H, br), 7.56-7.50 (2H, m), 7.40-7, 35 (2H, m), 7.17-7.12 (2H, m), 6.85-6.80 (2H, m), 5.57 (2H, s), 4.52 (2H, d) , 3.80 (3H, s) 14-80 9.31 (1H, s), 8.88 (1H, s), 7.91 (1H, d), 7.67-7.61 (2H, m), 7.56-7.51 (2H, m), 7.34-7.29 (1H, m), 7.22-7.09 (3H, m), 5.69-5.51 (3H, m), 1, 48 (3H, d) 14-81 9.30 (1H, s), 8.89 (1H, s), 7.70 (1H, d), 7.68-7.63 (2H, m), 7.55-7.50 (2H, m), 7.25-7.15 (3H, m), 7.10-7.05 (1H, m), 5.65 (1H, d), 5.59 (1H, d), 5.22 (1H, dq), 1.44 (3H, d) 14-82 9.30 (1H, s), 8.88 (1H, s), 7.70-7.63 (2H, m), 7.54-7.48 (2H, m),7.25-7.19 (2H, m), 7.14-7.08 (2H, m), 5.60 (2H, s), 5.22 (1H, dq), 1.43 (3H, d) 14-83 9.31 (1H, s), 8.84 (1H, s), 7.67-7.62 (2H, m), 7.47-7.35 (3H, m),7.24-7.19 (2H, m), 7.10-7.04 (2H, m), 5.57 (2H, s), 3.70 (2H, dt), 2.84 (2H, t) 14-84 9.31 (1H, s), 8.82 (1H, s), 7.64-7.58 (2H, m), 7.50-7.41 (1H, br), 7.38-7, 32 (2H, m), 7.11-7.05 (2H, m), 6.84-6.77 (2H, m), 5.55 (2H, s), 3.74 (3H, s) , 3.71 (2H, dt), 2.82 (2H, t) 14-85 9.31 (1H, s), 8.88 (1H, s), 7.68-7.62 (2H, m), 7.59-7.54 (2H, m), 7.46-7, 37 (1H, br), 7.24-7.18 (2H, m), 7.04-6.97 (2H, m), 5.65 (2H, s), 3.43 (2H, dt) , 2.54 (2H, t), 1.80 (2H, tt) 14-86 10.0-9.90 (1H, br), 9.42 (1H, s), 8.92 (1H, s), 8.63-8.56 (1H, m), 7.70-7, 62 (4H, m), 7.38-7.28 (2H, m), 7.10-7.04 (1H, m), 5.79 (2H, s) 97/150 Table 13 (continued) Comp. At the. 1 H-NMR data 14-87 9.38 (1H, s), 9.36-9.30 (1H, br), 8.94 (1H, s), 7.79-7.74 (2H, m), 7.70-7, 65 (2H, m), 7.49-7.45 (1H, m), 7.23-7.18 (2H, m), 7.13-7.05 (1H, m), 5.71 ( 2H, s) 14-88 9.38 (1H, s), 9.34-9.27 (1H, br), 8.94 (1H, s), 7.77-7.72 (2H, m), 7.69-7, 64 (2H, m), 7.35-7.29 (2H, m), 7.27-7.22 (2H, m), 5.71 (2H, s) 14-89 9.87 (1H, s), 9.46-9.37 (1H, br), 8.94 (1H, s), 8.60-8.54 (1H, m), 7.70-7, 66 (2H, m), 7.66-7.61 (2H, m), 7.36-7.34 (1H, m), 7.30-7.25 (1H, m), 5.78 ( 2H, s) 14-90 9.40-9.34 (2H, m), 8.95 (1H, s), 7.82-7.76 (2H, m), 7.71-7.66 (2H, m), 7, 31-7.28 (2H, m), 7.10-7.07 (1H, m), 5.70 (2H, s) 14-91 8.66 (1H, s), 8.45 (1H, s), 7.69-7.62 (2H, m), 7.53-7.45 (2H, m), 7.18-7, 10 (1H, m), 7.10-6.98 (2H, m), 6.89-6.76 (1H, m), 5.37 (2H, s), 3.43 (3H, s) 14-92 8.65 (1H, s), 8.44 (1H, s), 7.68-7.63 (2H, m), 7.50-7.41 (2H, m), 7.12-7, 01 (2H, m), 6.92-6.82 (2H, m), 5.38 (2H, s), 3.43 (3H, s) 14-93 10.0-9.90 (1H, br), 9.40 (1H, s), 8.89 (1H, s), 8.58-8.52 (1H, m), 7.71-7, 63 (4H, m), 7.11-7.04 (1H, m), 7.03-6.96 (1H, m), 6.86-6.80 (1H, m), 5.76 ( 2H, s), 3.45 (3H, s) 14-94 9.37 (1H, s), 9.33-9.26 (1H, br), 8.92 (1H, s), 7.77-7.71 (2H, d), 7.70-7, 65 (2H, d), 7.20-7.13 (1H, m), 7.13-7.10 (1H, m), 6.85-6.80 (1H, m), 6.69-6.63 (1H, m), 5.69 (2H, s), 3.74 (3H, s) 14-95 9.38 (1H, s), 9.24-9.15 (1H, br), 8.91 (1H, s), 7.76-7.70 (2H, m), 7.68-7, 62 (2H, m), 7.35-7.28 (2H, m), 6.86-6.79 (2H, m),5.70 (2H, s), 3.78 (3H, s) 14-96 9.36 (1H, s), 9.06-8.94 (1H, br), 8.85 (1H, s), 8.10-8.04 (1H, m), 7.64-7, 58 (2H, m), 7.57-7.52 (2H, m), 7.20-7.11 (1H, m), 7.06-7.01 (1H, m), 7.01- 6.94 (1H, m), 5.66 (2H, s), 1.78 (3H, s) 14-97 9.39 (1H, s), 9.33-9.22 (1H, br), 8.92 (1H, s), 7.78-7.72 (2H, m), 7.71-7, 65 (2H, m), 7.30-7.23 (1H, m), 7.21-7.14 (1H, m), 7.11-7.06 (1H, m), 6.96- 6.90 (1H, m), 5.69 (2H, s), 2.28 (3H, s) 14-98 9.41 (1H, s), 9.29-9.20 (1H, br), 8.93 (1H, s), 7.76-7.72 (2H, m), 7.69-7, 63 (2H, m), 7.31-7.26 (2H, m), 7.14-7.08 (2H, m), 5.71 (2H, s), 2.32 (3H, s) 98/150 Table 13 (continued) Comp. At the. 1 H-NMR data 14-99 9.39 (1H, s), 9.29-9.21 (1H, br), 8.92 (1H, s), 7.75-7.70 (2H, m), 7.68-7, 62 (2H, m), 7.38-7.33 (2H, m), 7.16-7.10 (2H, m), 6.96-6.91 (2H, m), 6.91- 6.86 (2H, m), 5.72 (2H, s), 2.33 (3H, s) 14-100 9.39 (1H, s), 9.32-9.25 (1H, br), 8.93 (1H, s), 7.76-7.71 (2H, m), 7.69-7, 64 (2H, m), 7.41-7.35 (2H, m), 7.30-7.24 (2H, m), 6.98-6.93 (2H, m), 6.93- 6.88 (2H, m), 5.73 (2H, s) 14-101 9.35 (1H, s), 8.89 (1H, s), 7.74-7.66 (1H, br), 7.60-7.55 (2H, m), 7.46-7, 40 (2H, m), 7.29-7.25 (2H, m), 7.23-7.18 (2H, m), 7.02-6.91 (4H, m), 5.61 ( 2H, s), 4.58 (2H, d) 14-110 8.72 (1H, s), 8.43 (1H, s), 7.65 (2H, d), 7.55 (2H, d), 5.52 (2H, s), 4.39 (2H , s), 2.80 (3H, s), 2.78 (3H, s) 14-111 * 8.73 (1H, s), 8.45 (1H, bs), 7.65 (2H, d), 7.55 (2H, d), 5.53 (2H, s), 4.48 (2H , bs), 3.75 (3H, bs), 2.91 (3H, bs) 8.73 (1H, s), 8.39 (1H, bs), 7.65 (2H, d), 7, 55 (2H, d), 5.53 (2H, s), 4.43 (2H, bs), 3.66 (3H, bs), 2.95 (3H, bs) 15-5 8.74 (1H, s), 8.66 (1H, s), 7.55 (1H, d), 7.45 (1H, d), 7.28 (1H, dd), 5.58 (1H , s), 5.46 (2H, s), 4.67 (1H, d), 3.37 (6H, s) 15-72 8.78 (1H, s), 8.71 (1H, s), 7.66-7.62 (2H, m), 7.59-7.53 (2H, m),6.09 (1H, s), 5.57 (2H, s), 4.51-4.44 (1H, m), 4.24 (1H, dd),4.19 (1H, dd), 4.14 (1H, dd), 3.96 (1H, dd), 2.08 (3H, s) 15-73 8.77 (1H, s), 8.63 (1H, s), 7.67-7.62 (2H, m), 7.59-7.53 (2H, m),6.20 (1H, s), 5.57 (2H, s), 4.54-4.48 (1H, m), 4.28-4.22 (3H, m),3.83 (1H, dd), 2.10 (3H, s) 15-90 8.74 (1H, s), 8.65 (1H, s), 7.65 (2H, d), 7.52 (2H, d), 5.53 (2H, dd), 5.22-5 , 18 (2H, m), 4.23 (1H, dd), 3.82 (1H, dd), 1.55 (3H, s) 15-91 8.73 (1H, s), 8.66 (1H, s), 7.64 (2H, d), 7.52 (2H, d), 5.55 (2H, dd), 5.22 (1H , t), 5.02 (1H, t), 4.44 (1H, dd), 3.78 (1H, dd), 1.86-1.75 (2H, m), 1.07-1, 01 (3H, m) 15-92 8.74-8.59 (2H, m), 7.64 (2H, d), 7.53 (2H, d), 5.60-5.53 (2H, m), 5.19-5, 05 (1H, m), 4.35-4.31 (1H, m), 3.78-3.35 (2H, m), 1.68-1.57 (2H, m), 0.92- 0.79 (2H, m) 15-112 8.80 (1H, s), 8.69 (1H, s), 7.65 (2H, d), 7.54 (2H, d), 6.07 (1H, s), 5.57 (2H , s), 4.08-3.99 (4H, m) *) mixing two types of rotamers 99/150 N ^ N (I-3) Table 14 Comp. At the. R 1 (X) m property value 14-1 CH = C (CN) CO2Me 4-CF3 125-131 14-2 CH2CH2SEt 4-CF3 1.3286 (21.8) 14-3 CH2CH2CH2SMe 4-OCF3 1.3081 (27.8) 14-4 CH2CO2Me 4-CF3 1.5082 (27.6) 14-5 CH2CH2CH2Cl 4-CF3 1.5038 (24.9) 14-6 CH2CO2H 4-CF3 175-180 14-7 CH (OH) CH2OCH (OEt) Me 4-CF3 NMR 14-8 CH (OH) CH2OCH (OMe) Et 4-CF3 NMR 14-9 CH = C (CN) 2 4-CF3 NMR 14-10 CH = c-Pr 4-CF3 53-56 14-11 CH (OH) c-Pr 4-CF3 1.3532 (25.8) 14-12 CH = CHEt 4-CF3 NMR 14-13 CH = CHCH2CH2Cl 4-CF3 NMR 14-14 CH (OMe) c-Pr 4-CF3 1.4978 (25.7) 14-15 CH = C- (1,3-dioxolan-2-yl) 4-CF3 NMR 14-16 CH = C- (1,3-dioxolan-2-yl) 4-CF3 70-74 14-17 CH2CH2- (1,3-dioxolan-2-yl) 4-CF3 NMR 14-18 CH = CHCH2CH2OCOCF3 4-CF3 1.3688 (25.1) 14-19 CH (OCOCF3) -c-Pr 4-CF3 NMR 14-20 CO-c-Pr 4-CF3 91-92 14-21 CH (OH) CH2CO2Me 4-CF3 88-90 14-22 CH (OH) CH2CO2H 4-CF3 144-145 14-23 CH = C (CO2Me) 2 4-CF3 1.4172 (24.3) 14-24 (2.2- (CO2Me) 2) -c-Pr 4-CF3 84-87 14-25 CH2Cl 4-CF3 82-85 14-26 CH2CH (CO2Me) 2 4-CF3 70-71 100/150 Table 14 (continued) Comp. At the. R 1 (X) m property value 14-27 CH = CHCOMe 4-CF3 95-98 14-28 CH (OH) CH2CO2Me 4-CF3 NMR 14-29 CH 2 - (pyrrolidin-1-yl) 4-CF3 1.5172 (22.2) 14-30 CH2NHCOEt 4-CF3 123-124 14-31 CH2NHCOCH2CH2CH2Cl 4-CF3 84-88 14-32 O 4-CF3 1.5215 (18.8) 14-33 V> O^ NH 4-CF3 129-132 14-34 CH (OH) CF3 4-CF3 132-134 14-35 C (OH) 2CF3 4-CF3 75-79 14-36 V> o 4-CF3 143-144 14-37 CH2NHMe 4-CF3 1.5020 (22.5) 14-38 CH2N (Me) COMe 4-CF3 101-102 14-39 CH2NHPh 4-CF3 1.5641 (21.4) 14-40 CH2N (Ph) COMe 4-CF3 1.5396 (21.3) 14-41 CH2N (Ph) COCF3 4-CF3 1.5173 (21.7) 14-42 CH2NH-c-Pr 4-CF3 1.5132 (21.4) 14-43 CH 2 - (piperidin-1-yl) 4-CF3 1.5098 (21.6) 14-44 CHMe = CH2 4-CF3 1.4006 (21.1) 14-45 CH2-c-Pr 4-CF3 NMR 14-46 CONH (CH2- (4-F-Ph)) 4-CF3 107-108 14-47 CH = CMe2 4-CF3 1.4781 (21.4) 14-48 CH = CHMe 4-CF3 1.4537 (21.6) 14-49 CH2NEt2 4-CF3 1.4973 (21.5) 14-50 CH2NHCH2CF3 4-CF3 1.4815 (21.5) 14-51 * Y ° y = °O 4-CF3 95-96 101/150 Table 14 (continued) Comp. At the. R 1 (X) m property value 14-52 CBr = CH2 4-CF3 1.3921 (21.4) 14-53 c-Pr- (1-CO2Me) 4-CF3 NMR 14-54 CH2OEt 4-CF3 1.4027 (21.7) 14-55 CMe2CO2Me 4-CF3 1.4679 (20.5) 14-56 CH (OMe) CF3 4-CF3 NMR 14-57 CH2SEt 4-CF3 1.5173 (20.9) 14-58 CH2SOEt 4-CF3 70-71 14-59 CH2SO2Et 4-CF3 77-78 14-60 CH2O-i-Pr 4-CF3 NMR 14-61 CH2N (CH2CF3) COMe 4-CF3 1.4869 (21.2) 14-62 CH = CHCO2Me 4-CF3 93-96 14-63 CH = CHCN 4-CF3 88-91 14-64 CH = CHCN 4-CF3 70-72 14-65 CH2CN 4-CF3 88-89 14-66 C (= CH2) CeCTMS 4-CF3 52-54 14-67 CH2S (= NCN) Et 4-CF3 1.3767 (21.9) 14-68 CONH-i-Pr 4-CF3 NMR 14-69 CONH-t-Bu 4-CF3 NMR 14-70 CONH-c-Hex 4-CF3 NMR 14-71 CO- (pyrrolidin-1-yl) 4-CF3 NMR 14-72 CO- (morpholin-1-yl) 4-CF3 NMR 14-73 CONHCH2CH2NMe2 4-CF3 NMR 14-74 CONH (CH2- (2-Cl-Ph)) 4-CF3 NMR 14-75 CONH (CH2- (3-Cl-Ph)) 4-CF3 NMR 14-76 CONH (CH2- (4-Cl-Ph)) 4-CF3 NMR 14-77 CONH (CH2- (2-OMe-Ph)) 4-CF3 NMR 14-78 CONH (CH2- (3-OMe-Ph)) 4-CF3 NMR 14-79 CONH (CH2- (4-OMe-Ph)) 4-CF3 NMR 14-80 CONH (CHMe- (2-Cl-Ph)) 4-CF3 NMR 102/150 Table 14 (continued) Comp. At the. R 1 (X) m property value 14-81 CONH (CHMe- (3-Cl-Ph)) 4-CF3 NMR 14-82 CONH (CHMe- (4-Cl-Ph)) 4-CF3 NMR 14-83 CONH (CH2CH2- (4-Cl-Ph)) 4-CF3 NMR 14-84 CONH (CH2CH2- (4-OMe-Ph)) 4-CF3 NMR 14-85 CONH (CH2CH2CH2- (4-Cl-Ph)) 4-CF3 NMR 14-86 CONH- (2-Cl-Ph) 4-CF3 NMR 14-87 CONH- (3-Cl-Ph) 4-CF3 NMR 14-88 CONH- (4-Cl-Ph) 4-CF3 NMR 14-89 CONH- (2,4-Cl2-Ph) 4-CF3 NMR 14-90 CONH- (3,5-Cl2-Ph) 4-CF3 NMR 14-91 CON (Me) (3-Cl-Ph) 4-CF3 NMR 14-92 CON (Me) (4-Cl-Ph) 4-CF3 NMR 14-93 CONH- (2-OMe-Ph) 4-CF3 NMR 14-94 CONH- (3-OMe-Ph) 4-CF3 NMR 14-95 CONH- (4-OMe-Ph) 4-CF3 NMR 14-96 CONH- (2-Me-Ph) 4-CF3 NMR 14-97 CONH- (3-Me-Ph) 4-CF3 NMR 14-98 CONH- (4-Me-Ph) 4-CF3 NMR 14-99 CONH- (4- (4-Me-PhO) -Ph) 4-CF3 NMR 14-100 CONH- (4- (4-Cl-PhO) -Ph) 4-CF3 NMR 14-101 CONH- (CH2- (4- (4-OCF3-PhO) -Ph)) 4-CF3 NMR 14-102 c-Pr- (2-CO2Me) 4-CF3 112-114 14-103 C (OH) (OMe) CF3 4-CF3 62-65 14-104 Et 4-CF(CF3) 2 1.4557(20.1) 14-105 Et 4-SCF3 43-44 14-106 c-Pr- (1-CN) 4-CF3 119-121 14-107 CH2S (= NCOCF3) Et 4-CF3 127-129 103/150 Table 14 (continued) Comp. At the. R 1 (X) m property value 14-108 CH2N (Me) (CO-c-Pr) 4-CF3 1.5280 (20.7) 14-109 CH2N (Me) (SO2Me) 4-CF3 94-96 14-110 CH2N (Me) (CONMe2) 4-CF3 NMR 14-111 CH2N (Me) (CO2Me) 4-CF3 NMR 14-112 CH2N (Me) (CO-i-Pr) 4-CF3 1.4311 (20.7) 14-113 CH2N (Me) (CO-n-Pr) 4-CF3 1.4200 (20.7) 14-114 CH2NH (CO-i-Pr) 4-CF3 155-165 14-115 CH2NH (CO-n-Pr) 4-CF3 80-85 14-116 CH2N (n-Pr) 2 4-CF3 1.4974 (21.9) 14-117 c-Pr 4-CF (CF3) 2 1.4050 (21.4) 14-118 c-Pr 4-CF2CF3 1.5002 (21.4) 14-119 c-Pr 4-Cl 38-40 14-120 c-Pr 4-Br 40-41 14-121 c-Pr 2-F-4-CF3 1.4920 (21.4) 14-122 Et 4-CH2CF3 66-68 14-123 CMe2CN 4-CF3 58-59 N ^ N (1-3) Table 15 Comp. At the. R 1 (X) m property value 15-1 CH (OMe) 2 4-Br 1.4476 (25.2) 15-2 CH (OMe) 2 4-I 1.4313 (25.4) 15-3 CH (OMe) 2 4-F 1.4741 (23.5) 15-4 CH (OMe) 2 4-Cl 1.4752 (23.4) 15-5 CH (OMe) 2 3,4-Cl2 NMR 15-6 CH (OMe) 2 2,4-Cl2 50-51 15-7 CH (OMe) 2 2,4-F2 59-60 104/150 Table 15 (continued) Comp. At the. R 1 (X) m property value 15-8 CH (OMe) 2 3,4-F2 1.5038 (18.5) 15-9 4-Me-1,3-dioxolan-2-yl 4-Br 72-74 15-10 4-Me-1,3-dioxolan-2-yl 4-Br 1.3813 (23.4) 15-11 4-Me-1,3-dioxolan-2-yl 4-I 1.4034 (23.3) 15-12 4-Me-1,3-dioxolan-2-yl 4-I 1.4433 (23.3) 15-13 4-Me-1,3-dioxolan-2-yl 4-t-Bu 1.5201 (26.7) 15-14 4-Me-1,3-dioxolan-2-yl 4-OCF3 1.4885 (26.7) 15-15 4-Me-1,3-dioxolan-2-yl 4-F 1.4648 (26.7) 15-16 4-Me-1,3-dioxolan-2-yl 4-Cl 1.4316 (26.7) 15-17 4-Me-1,3-dioxolan-2-yl 3,4-Cl2 1.4264 (26.7) 15-18 4-Me-1,3-dioxolan-2-yl 3,4-F2 1.4627 (26.7) 15-19 4-Me-1,3-dioxolan-2-yl 2,4-F2 1.4989 (26.7) 15-20 1,3-dioxan-2-yl 4-Me 94-95 15-21 1,3-dioxan-2-yl 4-F 94-95 15-22 1,3-dioxan-2-yl 4-Br 114-116 15-23 1,3-dioxan-2-yl 4-OMe 1.5553 (25.3) 15-24 1,3-dioxan-2-yl 4-SMe 1.4365 (25.1) 15-25 1,3-dioxan-2-yl 4-Et 1.4075 (24.5) 15-26 1,3-dioxan-2-yl 4-OEt 67-69 15-27 1,3-dioxan-2-yl 4-NO2 175-179 15-28 1,3-dioxan-2-yl 3,4-Cl2 141-145 15-29 1,3-dioxan-2-yl 2,4-Cl2 147-149 15-30 1,3-dioxan-2-yl 3,4-F2 145-149 15-31 1,3-dioxan-2-yl 2,4-F2 110-111 15-32 1,3-dioxan-2-yl 2-Br 107-110 15-33 1,3-dioxan-2-yl 3-CF3 85-90 15-34 1,3-dioxan-2-yl 4-I 133-135 15-35 1,3-dioxan-2-yl 2-F-4-Cl 139-140 15-36 1,3-dioxan-2-yl 4-OCHF2 87-88 15-37 1,3-dioxan-2-yl 2-Cl-4-F 117-118 105/150 Table 15 (continued) Comp. At the. R 1 (X) m property value 15-38 1,3-dioxan-2-yl 2-Cl-4-Br 141-142 15-39 1,3-dioxan-2-yl 2-F-4-Br 133-134 15-40 1,3-dioxan-2-yl 4-CF (CF3) 2 130-131 15-41 1,3-dioxan-2-yl 3-F-4-CF3 166-167 15-42 1,3-dioxan-2-yl 3-Br 109-111 15-43 1,3-dioxan-2-yl 2-CF3 93-94 15-44 1,3-dioxan-2-yl 2.5-Cl2 170-172 15-45 1,3-dioxan-2-yl 2,6-Cl2 119-121 15-46 1,3-dioxan-2-yl 2-F-5-CF3 96-97 15-47 1,3-dioxan-2-yl 4-CHF2 105-106 15-48 1,3-dioxan-2-yl 4-CF2CF2CF3 99-100 15-49 1,3-dioxan-2-yl 4-COMe (CF3) 2 142-147 15-50 1,3-dioxan-2-yl 4- (4-SCF3-Ph) 103-104 15-51 1,3-dioxan-2-yl 4- (4-OCF3-Ph) 72-75 15-52 1,3-dioxan-2-yl 4-CF2CF3 105-107 15-53 1,3-dioxan-2-yl 4-OCF2CHFCF3 49-50 15-54 1,3-dioxan-2-yl 4-SCF2CF3 129-130 15-55 1,3-dioxan-2-yl 4- (3-CF3-Ph) 117-118 15-56 1,3-dioxan-2-yl 4- (2-CF3-Ph) 71-72 15-57 1,3-dioxan-2-yl 4- (4-OCF3-PhO) 1.3991 (21.0) 15-58 1,3-dioxan-2-yl 4-CH2CF3 139-140 15-59 1,3-dioxan-2-yl 4-OCF2CHFOCF3 64-66 15-60 1,3-dioxan-2-yl 4-CF3 1.4924 (27.4) 15-61 1,3-dioxan-2-yl 4-Br 1.4364 (25.2) 15-62 1,3-dioxepan-2-ila 4-CF3 39-41 15-63 1,3-dioxolan-2-yl 4-CF3 1.3338 (24.8) 15-64 1,3-dioxepan-2-ila 4-Br 56-61 15-65 1,3-dioxepan-2-ila 4-I 91-94 15-66 1,3-dioxepan-2-ila 4-F 85-90 106/150 Table 15 (continued) Comp.At the. R 1 (X) m property value 15-67 1,3-dioxepan-2-ila 4-Cl 85-87 15-68 1,3-dioxepan-2-ila 2,4-F2 133-134 15-69 1,3-dioxepan-2-ila 3,4-F2 108-111 15-70 1,3-dioxepan-2-ila 3,4-Cl2 124-125 15-71 1,3-dioxepan-2-ila 2,4-Cl2 120-122 15-72 (4-CH2OCOMe) -1,3-dioxolan-2-yl 4-CF3 NMR 15-73 (4-CH2OCOMe) -1,3-dioxolan-2-yl 4-CF3 NMR 15-74 4-Ph-1,3-dioxolan-2-yl 4-CF3 1.3289 (25.6) 15-75 (4-CH 2 OMe) -1,3-dioxolan-2-yl 4-CF3 1.4392 (25.6) 15-76 (4,4,5,5-Me 4 ) -1,3-dioxolan-2-yl 4-CF3 1.3793 (25.4) 15-77 (4-CH 2 Cl) -1,3-dioxolan-2-yl 4-CF3 86-88 15-78 (4-CH 2 Cl) -1,3-dioxolan-2-yl 4-CF3 1.4772 (25.7) 15-79 (4-CH 2 OH) -1,3-dioxolan-2-yl 4-CF3 85-87 15-80 (4-CH 2 OH) -1,3-dioxolan-2-yl 4-CF3 110-113 15-81 (4-CH 2 OCH 2 CH = CH 2 ) -1,3-dioxolan-2-yl 4-CF3 1.4660 (25.5) 15-82 (4-CH2OPh) -1,3-dioxolan-2-yl 4-CF3 40-42 15-83 (4-CH2OPh) -1,3-dioxolan-2-yl 4-CF3 69-70 15-84 (4-CH = CH 2 ) -1,3-dioxolan-2-yl 4-CF3 1.4984 (25.6) 15-85 &H 4-CF3 76-77 15-86 (4,5- (CH 2 Cl) 2 ) -1,3-dioxolan-2-yl 4-CF3 76-79 15-87 (4-CH 2 F) -1,3-dioxolan-2-yl 4-CF3 80-83 15-88 (4-CH 2 F) -1,3-dioxolan-2-yl 4-CF3 70-72 15-89 (4-CH 2 SO 2 Me) -1,3-dioxolan-2-yl 4-CF3 98-101 15-90 (2-Me) -1,3-dioxolan-4-yl 4-CF3 NMR 15-91 (2-Et) -1,3-dioxolan-4-yl 4-CF3 NMR 107/150 Table 15 (continued) Comp. At the. R 1 (X) m property value 15-92 (2-Et) -1,3-dioxolan-4-yl 4-CF3 NMR 15-93 (2-Ph) -1,3-dioxolan-4-yl 4-CF3 1.5144 (25.5) 15-94 (2-Ph) -1,3-dioxolan-4-yl 4-CF3 1.5054 (25.4) 15-95 O 4-CF3 130-137 15-96 ~ DC °>O ^ '—o 4-CF3 147-150 15-97 (4,4-Me 2 ) -1,3-dioxan-2-yl 4-CF3 78-81 15-98 (4,4,6-Me 3 ) -1,3-dioxan-2-yl 4-CF3 137-138 15-99 (4,4,6,6-Me 4 ) -1,3-dioxan-2-yl 4-CF3 128-130 15-100 xo 4-CF3 91-93 15-101 (5-Me) - (5-CH2 ° H) -1,3-dioxan-2-ila 4-CF3 143-145 15-102 (5-Me) - (5-CH2 ° H) -1,3-dioxan-3-ila 4-CF3 149-151 15-103 (5-Ph) -1,3-dioxan-2-yl 4-CF3 152-155 15-104 (5-CH2 ° H) -1,3-dioxan-2-yl 4-CF3 186-187 15-105 (5-CH2 ° H) -1,3-dioxan-2-yl 4-CF3 160-162 15-106 · 4-CF3 1.5074 (25.1) 15-107 (5-CH 2 ° S ° 2 Me) -1,3-dioxan-2-yl 4-CF3 114-116 15-108 •O-S S ^ 4-CF3 172-175 15-109 (5-CH2F) -1,3-dioxan-2-yl 4-CF3 115-117 15-110 (4-CF 3 ) -1,3-dioxan-2-yl 4-CF3 122-124 108/150 Table 15 (continued) Comp.At the. R 1 (X) m property value 15-111 (5,5-F 2 ) -1,3-dioxan-2-yl 4-CF3 153-156 15-112 (5,5,6,6-F 4 ) -1,3-dioxepan-2-yl 4-CF3 NMR 15-113 1,3-dioxepan-2-ila 4-CF (CF3) 2 78-79 15-114 CH (OMe) 2 4-CF (CF3) 2 48-49 [0085] Agricultural insecticides containing the arylalkyloxypyrimidine derivative represented by formula (I) or salts thereof as an active ingredient are suitable for controlling various insect pests, such as agricultural insect pests, insect pests on grains stored, sanitary insect pests, nematodes, etc., which are harmful to hydroponic rice, fruit trees, vegetables, other crops, flowers and ornamental plants, etc. [0086] Examples of insects, insect nematodes, harmful nematodes mentioned above and the like include the following. [0087] Examples of the harmful insect pest of Lepidoptera include Parasa consocia, Anomis mesogona, Papilio xuthus, Matsumuraeses azukivora, Ostrinia scapulalis, Spodoptera exempta, Hyphantria cunea, Ostrinia furnacalis, Pseudaletia separata, Tinea translucensura, Paracuria, , Parnara guttata, Sesamia inferens, Brachmia triannulella, Monema flavescens, Trichoplusia ni, Pleuroptya ruralis, Cystidia couaggaria, Lampides boeticus, Cephonodes hilaas, Helicoverpa armigera, Phalerodonta manleyi, Eumeta japonica, masisomaeysis, pysterne Archips xilaosteanus, Agrotis segetum, Tetramoera schistaceana, Papilio machaon hippocrates, Endoclyta sinensis, Lyonetia prunifoliella, Philalonorycter ringoneella, Cydia kurokoi, Eucoenogenes aestuosa, Lobesia botrana, Latoia sinica, Euzopha 109/150 Spilosoma imparilis, Glyphodes pilaoalis, Olethreutes mori, Tineola bisselliella, Endoclyta excrescens, Nemapogon granellus, Synanthedon hector, Cydia pomonella, Plutella xilaostella, Cnaphalocrocella medinalis, Sesamia calamistis, operamia, Staphylia, exigua, Palpifer sexnotata, Spodoptera mauritia, Scirpophaga innotata, Xestia c-nigrum, Spodoptera depravata, Ephestia kuehniella, Angerona prunaria, Clostera anastomosis, Pseudoplusians, Matsumuraeses falcana, Eu theivora, Homona magnanima, Ephestia elutella, Eumeta minuscula, Clostera anachoreta, Heliothis maritima, Sparganothis pilleriana, Busseola fusca, Euproctis subflava, Biston robustum, Heliothis zea, Aedia leucomelas, Narosoideus flavidorsalis, Piriminia , Spulerina astaurota, Ectomyelois pirivorella, Chilo suppressalis, Acrolepiopsis sapporensis, Plodia interpunctella, Hellula undalis, Sitotroga cerealella, Spodoptera litura, Eucosma aporema, Acleris comariana, Scopelodes contractus, Orgyia thyellina, Spinaephragia, Androdina, Spodoptera, Spodoptera regalis, Acosmeryx castanea, Philalocnistis toparcha, Endopiza viteana, Eupoecillia ambiguella, Anticarsia gemmatalis, Cnephasia cinereipalpana, Lymantria dispar, Dendrolimus spectabilis, Leguminivora glycinivorella, Maruca testulalis, citrusisilisis, Philosophia Bambalina sp., Carposina niponensis, Conogethes punctiferalis, Synanthedon sp., Lyonetia clerkella, Papilio helenus, Colias erate poliographus, Phalera flavescens, Pieridae such as Pieris rapae crucivora, Pieris rapae and the like, Euproctis similis, Acrolepio nia nubilalis, Mamestra brassicae, Ascotis selenaria, Phtheochroi 110/150 des clandestina, Hoshinoa adumbratana, Odonestis pruni japonensis, Triaena intermedia, Adoxophyes orana fasciata, Grapholita inopinata, Spilonota ocellana, Spilonota lechriaspis, Illiberis pruni, Argyrestia conjugella, Flopia, Archipia Diaphania indica, Heliothis virescens, Earias cupreoviridis and the like. [0088] Examples of Hemiptera's harmful insect pest include Nezara antennata, Stenotus rubrovittatus, Graphosoma rubrolineatum, Trigonotilaus coelestialium, Aeschynteles maculatus, Creontiades pallidifer, Dysdercus cingulatus, Chrysomphalus ficus, Ausidian, Ausidia, Ausidia Lagynotomus elongatus, Thaia subrufa, Scotinophara lurida, Sitobion ibarae, Stariodes iwasakii, Aspidiotus destructor, Tailaorilygus pallidulus, Myzusmumecola, prunicola Pseudaulacaspis, Acyrthosiphon pisum, striicornis Anacanthocoris, micantulus Ectometopterus, Eysarcoris lewisi, sooty Molipteryx, viridis Cicadella, rufiabdominalis Rhopalosophum, Saissetia oleate, Trialeurodes vaporariorum, Aguriahana quercus, Lygus spp., Euceraphis punctipennis, Andaspis kashicola, Coccus pseudomagnoliarum, Cavelerius saccharivorus, Galeatus spinifrons, Macrosiphoniella sanborni, Aonidiella citrina, Halyomoric mixed Arina, Trioza camphorae chinensis Leptocorisa, quercicola Trioza, Uhlerites latius, Erythroneura eat, Paromius exiguus, Duplaspidiotus claviger, nigropictus Nephotettix, insularis Halticiellus, Perkinsiella saccharicida, malivorella Psilala, Anomomeura mori longispinis Pseudococcus, pentagona Pseudaulacaspis, Pulvinaria kuwacola, Apolygus lucorum, Togo hemipterus, Toxoptera aurantii, Saccharicoccus sacchari, Geoica lucifuga, Numata muiri, Comstockaspis perniciosa, Unaspis citri, Aulacorthum solani, Eysarcoris ventralis, Bemisia argentifolii, Cicadella spectra, Aspidiotus hederais, Hioralisis, Hygeria 111/150 ra, Megoura crassicauda, Brevicoryne brassicae, Aphis glycines, Leptocorisa oratorius, Nephotettix virescens, Uroeucon formosanum, Cyrtopeltis tennuis, Bemisia tabaci, Lecanium persicae, Parlatoria theae, Pseudaonidia paeoniaeeeeae, Eme Stephanitis pirioides, Ceroplastes ceriferus, Parlatoria camelliae, Apolygus spinolai, Nephotettix cincticeps, Glaucias subpunctatus, Orthotilaus flavosparsus, Rhopalosiphum maidis, Peregrinus maidis, Eysarcoris parvus, Cimexisularis, pirilisilisilisil, Psilalaala, Psilala , Parlatoreopsis piri, Stephanitis nashi, Dysmicoccus wistariae, Lepholeucaspis japonica, Sappaphis piri, Lipaphis erysimi, Neotoxoptera formosana, Rhopalosophum nymphaeae, Edwardsianarosae, Pinnaspisaspidistra, Ponaspisisidicis, Alisilicis, Panic, Alisilis, Alisolan atoria ziziphi, Uhlerites debile, Laodelphax striatellus, Eurydema pulchrum, Cletus trigonus, Clovia punctata, Empoasca sp., Coccus hesperidum, Pachybrachius luridus, Planococcus kraunhiae, Stenotus binotatus, Arboridia, Macorisia sordidus, Leptocorisa acuta, Macropes obnubilus, Cletus punctiger, Riptortus clavatus, Paratrioza cockerelli, Aphrophora costalis, Lygus disponsi, Lygus saundersi, Crisicoccus pini, Empoasca abietis, Crisicoccus matsumotoi, Munchi Toxoptera citricidus, Planococcus citri, Dialeurodes citri, Aleurocanthus spiniferus, Pseudococcus citriculus, Zyginella citri, Pulvinaria citricola, Coccus discrepans, Pseudaonidia duplex, Pulvinaria aurantii, Lecanium corni, Nezarahipanumisis, stanismahid, viria ci, Brachycaudus helichrysi, Carpocoris purpureipennis, Myzus persicae, Hyalopte 112/150 rus pruni, Aphis farinose yanagicola, Metasalis populi, Unaspis yanonensis, Mesohomotoma camphorae, Aphis spiraecola, Aphis pomi, Lepidosaphes ulmi, Psilala mali, Heterocordilaus flavipes, Myzus malisuctus, Aphidonugisisis, Mali, rubens, Aphis gossypii and the like. [0089] Examples of the harmful insect pest of Coleoptera include Xystrocera globosa, Paederus fuscipes, Eucetonia roelofsi, Callosobruchus chinensis, Cilaas formicarius, Hypera postica, Echinocnemus squameus, Oulema oryzae, Oulema oryzae, Donacia eysyase, Colycianusisusis, Eustetia, , varivestis Epilachna, Acanthoscelides obtectus, Diabrotica virgifera virgifera, cupreus Involvulus, femoralis Aulacophora, Bruchus pisorum, Epilachna vigintioctomaculata, dimidiatus Carpophilus nebula Cassida, tunebrosa Luperomorpha, Philalotreta striolata, hilaris Psacothea, Aeolesthes chrysothrix, Curculio sikkimensis, Carpophilus hemipterus, Óxicetonia jucunda, Diabrotica spp., Mimela splendens, Sitophilus zeamais, Tribolium castaneum, Sitophilus oryzae, Palorus subdepressus, Melolontha japonica, Anoplophora malasiaca, Neatus picipes, Leptinotarsa decemlineata, Diabrotica undecimpunctata howardi, Sphenopathata, Crocodopata Conotrachelus nenuphar, Ceuthorhynchidius albosuturalis, Phaedon brassicae, Lasioderma serricorne, Sitona japonicus, Adoretus tenuimaculatus, Tenebrio molitor, Basilepta balyi, Hypera nigrirostris, Chaetocnema concinna, Anomala cuprea, Epicoraceae, Epicoraceae, Heptophilic, vigilidae unicolor japonicus, Pagria signata, Anomala rufocuprea, Palorus ratzeburgii, Alphitobius laevigatus, Anthrenus verbasci, Lyctus brunneus, Tribolium confusum, Medytia nigrobilineata, Xilaotrechus pirrhoderus, Epitrix cucumeris, Monicillus, Tomicus pinicillis, Alternicillus, Tomicus pinicillis, Tomicus pinicis 113/150 heros, Listroderes costirostris, Callosobruchus maculatus, Philalobius armatus, Anthonomus pomorum, Linaeidea aenea, Anthonomus grandis and the like. [0090] Examples of the harmful insect pest of Diptera include Culex pipiens pallens, Pegomya hyoscyami, Liriomyza huidobrensis, Musca domestica, Clorops oryzae, Hydrellia sasakii, Agromyza oryzae, Hydrellia griseola, Ophiomyia phaseoli, Dacuscina, Racus stabulans, Phoridae such as Megaselia spiracularis and the like, Clogmia albipunctata, Tipula aino, Phormia regina, Culex tritaeniorhynchus, Anopheles sinensis, Hilaemya brassicae, Asphondilaia sp., Delia platura, Delia antiqua, Rhagoletis ceri, Molexis agrestis, Pegomya cunicularia, Liriomyza sativae, Liriomyza bryoniae, Chromatomyia horticola, Liriomyza chinensis, Culex quinquefasciatus, Aedes aegypti, Aedes albopictus, Liriomyza trifolii, Liriomyza sativae, Dacus dorsalisis, Migrant, dorsalis, dacal similar. [0091] Examples of the harmful insect pest of Hymenoptera include Pristomyrmex pungens, Betilidae, Monomorium pharaohnis, Pheidole noda, Athalia rosae, Dryocosmus kuriphilus, Formica fusca japonica, Vespoidea, Athalia infumata, Arge pagana, Spyria, Spinae, Acromia, sp. ., Arge mali, Ochetellus glaber and the like. [0092] Examples of Orthoptera's harmful insect pest include Homorocoryphus lineosus, Grilalotalpa sp., Óxia hilaa intricata, Óxia yezoensis, Locusta migratoria, Óxia japonica, Homorocoryphus jezoensis, Teleogrilalus emma and the like. [0093] Examples of Thripidae's harmful insect pest include Selenothrips rubrocinctus, Stenchaetothrips biformis, Haplo 114/150 thrips aculeatus, Ponticulothrips diospirosi, Thrips flavus, Anaphothrips obscurus, Liothrips floridensis, Thrips simplex, Thrips nigropilosus, Heliothrips haemorrhoidalis, Pseudodendrothripsori Thripsripsrothsipsiothysipsisis, lichensothisipsisis, Leeuwen , Scirtothrips dorsalis, Dendrothrips minowai, Haplothrips niger, Thrips tabaci, Thrips alliorum, Thrips hawaiiensis, Haplothrips kurdjumovi, Chirothrips manicatus, Frankliniella intonsa, Thrips coloratus, Franklinella occidentalis, Thrips palmi, Frankipsiora, Frankipsi, Thrips palmi. [0094] Examples of the harmful insect pest of Acari include Leptotrombidium akamushi, Tetranychus ludeni, Dermacentor variabilis, Tetranychus truncatus, Ornithonyssus bacoti, Demodex canis, Tetranychus viennensis, Tetranychus kanzawai, Tisran, etc. Dermatophagoides farinae, redback spider, Dermacentor taiwanicus, Acaphilala theavagrans, Polyphagotarsonemus latus, Aculops lycopersici, Ornithonyssus silavairum, Tetranychus urticae, Eriophyes chibaensis, Sarcoptes scabiei, Haemaphysalis longicornis, Ixodes scapularis, Tyrophagus similis, Cheilaetus eruditus, Panonychus citri, Cheilaetus hand-prayed, Brevipalpus phoenicis, Octodectes cynotis, Dermatophagoides ptrenyssnus, Haemaphysalis flava, Ixodes ovatus, Philalocoptruta citri, Aculus schlechtendali, Panonychus ulmi, Amblyomma americanum, Dermanyssus gallinae, Rhyzoglyassus, robin. and the like. [0095] Examples of the harmful insect pest of Termitidaenoxious include Reticulitermes miyatakei, Incisitermes minor, Coptotermes formosanus, Hodotermopsis japonica, Reticulitermes sp., Reticulitermes flaviceps amaianus, Glyptotermes kushimensis, Coptothermes kangzensensis, kangimensis, kangimensis, 115/150 mai, Glyptotermes satsumensis, Cryptotermes domesticus, Odontotermes formosanus, Glyptotermes nakajimai, Pericapritermes nitobei, Reticulitermes speratus and the like. [0096] Examples of the harmful insect pest of Blattaria include Periplaneta fuliginosa, Blattella germanica, Blatta orientalis, Periplaneta brunnea, Blattella lituricollis, Periplaneta japonica, American periplaneta and the like. [0097] Examples of Aphaniptera include Pulex irritans, Ctenocephalides felis, Ceratophilalus gallinae and the like. [0098] Examples of Nematoda include Nothotilaenchus acris, Aphelenchoides besseyi, Pratilaenchus penetrans, Meloidogyne hapla, Meloidogyne incognita, Globodera rostochiensis, Meloidogyne javanica, Heterodera glycines, Pratilaenchus coffeae, Pratilaenchususlegusus and semitransenususlect. [0099] Examples of Malacozoa include Pomacea canaliculata, Achatina fulica, Meghimatium bilineatum, Lehmannina valentiana, Limax flavus, Acusta despecta sieboldiana and the like. [0100] The agricultural insecticide of the present invention also has a strong control effect on tomato borer (Tuta absoluta) as another insect pest. [0101] In addition, as zoobiotic mites, which is one of the control targets, for example, Ixodes such as Bo-ophilus microplus, Rhipicephalus sanguineus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata, Haemaphysalis kalisis, , Haemaphysalis ias, Ixodes ovatus, Ixodes nipponensis, Ixodes persulcatus, Amblyomma testudinarium, Haemaphysalis megaspinosa, Dermacentor reticulatus and Dermacentor taiwanesis, Ornithonysumus such as Dermanyssus gallinae, Ornithonysromb, and Ornithonyssysisaris 116/150 pallidum, Leptotrombidium fuji, Leptotrombidium tosa, Neotrombicula autumnalis, Eutrombicula alfreddugesi and Helenicula miyagawai, Cheilaetidae such as Cheilaetiella yasguri, Cheilaetiella parasitivorax and Cheilaetiella blakei, such as Sarcophesi, Sarcoptes, and Sarcoptes Demodicidae such as Demodex canis and the like can be mentioned. [0102] As fleas, which is another control target, for example, insects without ectoparasitic wings belonging to Siphonaptera, more specifically fleas belonging to Pulicidae, Ceratephilalus and the like can be mentioned. Examples of the flea belonging to Pulicidae include Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Echidnophaga gallinacea, Xenopsilala cheopis, Leptopsilala segnis, Nosopsilalus fasciatus, Monopsilalus anisus and the like. [0103] Examples of external parasites, which are another control target, include Anoplura, such as short-nosed cattle lice (Haematopinus eurysternus), horse sucking lice (Haematopinus asini), sheep lice (Dalmalinia ovis), louse long-nosed cattle (Linognathus vituli), pig louse (Haematopinus suis), crab louse (Phthirus pubis) and head louse (Pediculus capitis); lice that bite, such as lice that bite dogs (Trichodectes canis); and dipterous blood-sucking insects, such as horsefly (Tabanus trigonus), mosquitoes that bite (Culicoides schultzei) and rubberflies (Simulium ornatum). In addition, examples of internal parasites include nematodes, such as lung worms, tricurids, tuberous worms, gastric parasites, ascaris and filarioid; cestoides, such as Spirometra erinacei, Diphilalobothrium latum, Dipilaidium caninum, Taenia multiceps, Echinococcus granulosus and Echinococcus multilocularis; trematodes, such as Schistosoma japonicum and Fasciola hepatica; and protozoa, such as coccidia, malaria parasites 117/150 ria, intestinal sarcocystitis, toxoplasma and cryptosporidium. [0104] The agricultural insecticide containing the arylalkyloxypyrimidine derivative represented by formula (I) or salts of the present invention as an active ingredient has an enhanced control effect on the insect pests exemplified above, which are harmful to crops in hydroponics , land crops, fruit trees, vegetables and other crops, ornamental plants and flowers and the like. Therefore, the desired effect of the agricultural insecticide of the present invention can be exhibited by applying the agents to the cultivation vehicle, such as seeds, rice field water, stems and leaves or soil from the propagation unit, hydroponics fields, field, fruit trees, vegetables, other crops or flowers and ornamental plants and the like at a time when pests are expected to appear before their appearance or when their appearance is confirmed. Particularly, a preferable form of use is application using what is called penetration transfer, which allows absorption of the compound of the present invention by the roots or through the soil by treating propagating soil for crops, flowers and ornamental plants and the like , soil from the planting pit for transplant, plant base, irrigation water, hydroponic culture water and the like. [0105] Useful plants for which the agricultural insecticide of the present invention can be used are not specifically limited and, for example, plants such as cereals (for example, rice, barley, wheat, rye, oats, corn, etc.) ; legumes (soybeans, azuki beans, fava beans, black-eyed beans, white beans, peanuts, etc.); fruit trees and fruits (apple, citrus, pear, grapes, peach, plum, cherry, nut, chestnut, almond, banana, etc.); vegetables (cabbage, tomato, spinach, broccoli, lettuce, onion, Welsh onion (chives, Wales onion), peppers, eggplant, strawberry, pepper, okra, leeks, 118/150 etc.), root vegetables (carrots, potatoes, sweet potatoes, taro, radish, turnip, lotus root, burdock, garlic, Japanese leeks, etc.), processing crops (cotton, flax, beet, hops, sugar cane, beets, olives, rubber, coffee, tobacco, tea, etc.); gourds (pumpkin, cucumber, watermelon, oriental melon, common melon, etc.); food crops (grass, sorghum, timothy, clover, alfalfa, etc.); grass (Korean grass, common lawn, etc.); culture for spices (lavender, rosemary, thyme, parsley, pepper, ginger, etc.); flowers (chrysanthemum, rose, carnation, orchid, tulip, lily, etc.), garden trees (gingko, Japanese cherry, aucuba, etc.), forest trees (Abies sachalinensis, Picea jezoensis, pine, Thujopsis dolabrata, Japanese cedar , Japanese cypress, eucalyptus, etc.) and the like can be mentioned. [0106] The plant mentioned above also includes plants to which resistance to herbicides has been conferred, for example, HPPD inhibitors, such as isoxaflutola and the like, ALS inhibitors, such as imazethapir, methyl thifensulfuron and the like, EPSP synthase inhibitors, such as glyphosate and the like, glutamine synthase inhibitors, like glufosinate and the like, acetyl CoA carboxylase inhibitors, like setoxydim and the like, Broxynil, dicamba, 2,4-D and the like, using a classic breeding method or gene recombination technique. [0107] Examples of the plant that has been given resistance by means of a classic breeding method include rapeseed, wheat, sunflower and rice resistant to imidazolinone ALS-inhibiting herbicides, such as imazethapir and the like, which are already commercially available as Clearfield trademark (registered trademark). Similarly, soybean resistant to sulfonylurea ALS-inhibiting herbicides, such as methyl thifensulfuron and the like through a classic breeding method is now commercially available 119/150 under the STS soy trademark. Similarly, examples of the plant to which resistance has been conferred to acetyl CoA carboxylase inhibitors, such as trione oxime herbicides and aryloxyphenoxypropionic acid and the like through a classical breeding method include SR maize and the like. [0108] The plant to which resistance has been conferred to acetyl CoA carboxylase inhibitors is described in Proc. Natl. Acad. Sci. USA, vol. 87, pages 7175 - 7179 (1990) and the like. In addition, resistance to mutated acetyl CoA carboxylase is reported in Weed Science, vol. 53, pages 728 - 746 (2005) and the like and a plant resistant to acetyl CoA carboxylase inhibitors can be produced by introducing such a mutated acetyl CoA carboxylase gene into a plant using a gene recombination technique or introduction of a mutation involved in conferring resistance to the acetyl CoA carboxylase in the plant. In addition, a plant resistant to acetyl CoA carboxylase inhibitor, ALS inhibitor and the like can be created by introducing a site-specific amino acid substitution mutation into the acetyl CoA carboxylase gene, ALS gene and the like plant by introducing a nucleic acid to introduce base substitution represented by a chimeraplasty technique (Gura T. 1999. Repairing the Genome's Spelling Mistakes. Science 285: 316-318) in the plant cell. The agricultural insecticide of the present invention can also be used for these plants. [0109] Furthermore, examples of the toxins produced in such genetically modified plants include insecticidal proteins derived from Bacillus cereus and Bacillus popilliae; insecticidal proteins, such as δ-endotoxins (for example, Cri1aAb, Cri1aAc, Cri1aF, Cri1aFa2, Cry2Ab, Cry3A, Cry3Bb1 and Cry9C), VIP1, VIP2, VIP3 and VIP3A, which are derived from Bacillus thuringiensis; toxins derived from 120/150 nematodes; toxins produced by animals, such as scorpion toxin, spider toxin, bee toxin and insect-specific neurotoxins; filamentous fungus toxins; plant lectins; agglutinin; protease inhibitors, such as trypsin inhibitors, serine protease inhibitor, patatin, cystatin and papain inhibitors; ribosome inactivating proteins (RIP), such as ricin, corn RIP, abrina, rufina, sapolina and priodina; steroidal metabolic enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-UDPglucosyl transferase and cholesterol oxidase; ecdysone inhibitors; HMG-CoA reductase; ion channel inhibitors, such as sodium channel inhibitors and calcium channel inhibitors; juvenile hormone esterase; diuretic hormone acceptors; stilbene synthetase; bibenzyl synthetase; chitinase; glucanase and the like. [0110] Toxins produced in such genetically modified plants also include hybrid toxins, partially deficient toxins and modified insecticidal protein toxins, such as δ-endotoxin proteins (eg, Cri1aAb, Cri1aAc, Cri1aF, Cri1aFa2, Cry2Ab, Cry3A, Cry3Bb1 , Cry9C, Cry34Ab and Cry35Ab), VIP1, VIP2, VIP3 and VIP3A. Hybrid toxins are produced by a new combination of different domains of such a protein when adopting recombination technology. The known partially deficient toxin is Cri1aAb, in which part of the amino acid sequence is deficient. In modified toxins, one or a plurality of amino acids from a natural toxin is replaced. [0111] Examples of such toxins and genetically modified plants capable of synthesizing such toxins are described in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A451 878 , WO 03/052073, etc. [0112] The toxins contained in such genetically modified plants confer resistance to Coleoptera insect pests, pests 121/150 of Hemiptera insects, Diptera insect pests, Lepidoptera insect pests and Nematoda insect pests to plants. The agricultural insecticide of the present invention can also be used in combination with or through systematization with such a technique. [0113] For the control of several pests, the agricultural insecticide of the present invention need only be applied to the plant where pests and nematodes are expected to occur as is or after being properly diluted or suspended in water or similar, in an effective amount for pest or nematode control. For example, for pests and nematodes that occur on fruit trees, cereals, vegetables and the like, the insecticide is sprayed on parts of the stem and leaves or absorbed by the roots through seed treatments, such as immersing the seeds in a drug, coating the seeds. seeds, stem treatment and the like, soil treatment, such as mixing in whole soil layers, application in the planting furrow, mixing in the bed soil, seedling treatment, planting pit treatment, plant base treatment, coating treatment, rice seed treatment, water surface application, etc. and the like. In addition, the agricultural insecticide can also be used through application to a culture fluid for culture with culture fluids (hydroponics), application through fogging or injection into tree trunks and the like. [0114] The agricultural insecticide of the present invention need only be applied to the place where pest development is expected to be as it is or after being properly diluted or suspended with water or the like, in an effective amount for pest control. For example, spraying on insects stored in grains, domestic pests, sanitary pests, forest pests and the like, as well as application by fumigation, home baits and architectural materials and the like can also be used for use. 122/150 [0115] As methods for treating seeds, conventional methods, such as a method comprising penetration of the agent by immersing the seeds in the liquid agent obtained by diluting or not diluting a liquid formulation or a solid formulation, a method comprising adhesion of a liquid formulation or solid formulation to the seed surface by mixing the formulation with the seeds, coating and the like, a method comprising mixing the formulation with adhesive vehicles such as resin, polymer and the like and forming a layer on the seeds, a method comprising application close to the seeds simultaneously with planting and the like can be mentioned. [0116] The seed to be subjected to seed treatment means a plant body in an early stage of growth which is used for propagation and includes seeds, as well as bulbs, tubers, seed tuber, germ, propagules, scaly bulbs, a plant body for vegetative propagation by cuttings and the like. [0117] The soil and cultivation vehicle for plant, when practicing the method of use of the present invention, means supports for growing plants, particularly supports for growing roots, and the material is not particularly limited. The material can be any one, as long as the plants can grow on it, and include specific materials, for example, soil, sowing mat, water and the like. As a specific material, sand, pumice, vermiculite, diatomaceous earth, agar, gelled substance, polymeric substance, rock wool, glass wool, wood chip, bark and the like can also be used. [0118] As an application method or stem and leaves of a crop plant or insects stored in grains, domestic animal pests, health pests or forest pests, a method 123/150 including suitable dilution of a liquid formulation, such as an emulsion, fluid formulation and the like or a solid formulation, such as wetting powder or water-dispersible granule and the like with water and spraying it, a powder spraying method or fogging and the like can be mentioned. [0119] For application to soil, for example, a method comprising application of a liquid formulation based on the plant or plant body, sowing for growth of seedlings and the like with or without dilution in water, a method comprising application of granules based or plant body or sowing for seedling growth, a method comprising application of powder, moistable powder, water-dispersible granules, granules and the like before transplanting or planting to allow them to be incorporated into the entire soil, a method comprising application to planting pit, planting furrow and the like with powder, moistable powder, water-dispersible granules, granules and the like before planting or transplanting and the like can be mentioned. [0120] In the case of paddy rice sowing, the formulation may vary according to the moment, for example, of application when planting, application during maturation, application during transplantation and the like. Powder formulations, water-dispersible granules, granules and the like can be used. It is also possible to apply it by incorporating it into the planting soil, in which the planting soil can be mixed with powder, water-dispersible granules, granules and the like and, for example, incorporation into the bed soil, incorporation into the cover soil, incorporation into the whole planting soil and the like can be used. Simply, a planting soil and several formulations can be applied in alternating layers. As a method of application to a rice field, a solid formulation, such as jumbo, package, granule, water dispersible granules 124/150 and the like, a fluid formulation, such as liquid, emulsion and the like, are generally sprayed onto a rice field. Alternatively, during rice planting, a suitable formulation can also be injected into the soil directly or after mixing with a fertilizer. In addition, using a liquid agent, such as emulsion, fluid and the like, to a water inlet and water flow source in rice paddies, such as an irrigation apparatus and the like, an application savings along with the water supply can also be obtained. [0121] For land crops, seed treatment, a cultivation vehicle to be placed close to the plant body and the like, during the period from planting to seedling growth is possible. For plants to be sown directly in the field, a direct seed treatment, a base treatment of a plant of the plant being cultivated and the like are preferable. An application of granules, an injection treatment into the soil with a liquid agent with or without dilution with water and the like can be done. Also, a preferable treatment is to mix the granules with a cultivation vehicle before sowing and mix with the seeds. [0122] For a treatment in planting or during seedling growth of a cultivated plant to be transplanted, a direct seed treatment, an injection treatment in the soil of a seedling for growing seedlings with a liquid agent or a treatment by dispersion of the even with granules are preferable. In addition, treating a planting pit with granules and mixing a growing vehicle to be placed close to the transplant site with the granules during planting correction are also preferable treatments. [0123] The agricultural insecticide of the present invention is generally prepared in conveniently usable forms according to 125/150 is a usual way of preparing agrochemicals. [0124] That is, the arylalkyloxypyrimidine oxide derivative of formula (I) or salts thereof of the present invention are mixed with a suitable inert carrier and, optionally, an adjuvant in a suitable proportion and prepared in a suitable preparation form, such as a suspension, emulsifiable concentrate, soluble concentrate, wetting powder, wetting granular powder, granules, powder, tablets, packets or the like by dissolving, dispersing, suspending, mixing, impregnating, adsorption or adhesion. [0125] The composition (agricultural, insecticide or animal parasite control agent) of the present invention may contain, in addition to active ingredients as needed, additional components generally used to prepare pesticides or animal parasite control agents. Examples of the additional component include vehicles, such as solid vehicle, liquid vehicle and the like, surfactant, dispersant, wetting agent, binder, tackifier, thickener, colorant, dispersant, adhesive, antifreeze agent, anti-caking agent, disintegrant, stabilizing agent and the like. If necessary, a preservative, plant residues and the like can be used as other additional components. These additional components can be used individually or in a mixture of two or more types of them. [0126] Examples of the solid vehicle include natural minerals, such as quartz, clay, kaolinite, pyrophyllalite, sericite, talc, bentonite, acid clay, atapulgite, zeolite, diatomaceous earth and the like; inorganic salts, such as calcium carbonate, ammonium sulfate, sodium sulfate, potassium chloride and the like; solid organic vehicles, such as synthetic silicic acid, synthetic silicate, starch, cellulose, a vegetable powder (for example, sawdust, coconut shell, corn cob, tobacco stalk and the like) and the like; plastic vehicles such as 126/150 by polyethylene, polypropylene, (poly) vinylidene chloride and the like; urea, hollow inorganic bodies, hollow plastic bodies, fumigated silica (white carbon) and the like. These can be used individually in a mixture of two or more types of them. [0127] Examples of the liquid carrier include alcohols, including monovalent alcohols, such as methanol, ethanol, propanol, isopropanol, butanol and the like and polyvalent alcohols, such as ethylene glycol, diethylene glycol, propylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol , glycerol and the like; polyhydric alcohol compounds, such as propylene glycol ether and the like; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, cyclohexanone and the like; ethers, such as ethyl ether, dioxane, ethylene glycol monoethyl ether, dipropyl ether, tetrahydrofuran and the like; aliphatic hydrocarbons, such as normal paraffins, naphthenes, isoparaffins, kerosenes, mineral oils and the like; aromatic hydrocarbons, such as benzene, toluene, xylene, naphtha solvent, alkylnaphthalenes and the like; halogenated hydrocarbons, such as dichloromethane, chloroform, similar carbon tetrachloride; esters, such as ethyl acetate, diisopropyl phthalate, dibutyl phthalate, dioctyl phthalate, dimethyl adipate and the like; lactones, such as □ -butyrolactone and the like; amides, such as dimethylformamide, diethylformamide, dimethylacetamide, N-alkylpyrrolidinone and the like; nitriles, such as acetonitrile and the like; sulfur compounds, such as dimethyl sulfoxide and the like; vegetable oils, such as soybean oil, rapeseed oil, cottonseed oil, castor oil and the like; water and the like. These can be used individually in a mixture of two or more types of them. [0128] Examples of the surfactant to be used as a dispersing or wetting agent include non-ionic surfactants, such as sorbitan fatty acid ester, polyoxyethylene sorbitan ester 127/150 fatty acids, fatty acid ester sucrose, polyoxyethylene fatty acid esters, polyoxyethylene resinate esters, polyoxyethylene fatty acid diesters, polyoxyethylene alkyl ethers, polyoxyethylene alkylethyl ethers, polyoxyethylene ethylene ethylphenylethylene ethylene dialkyl phenyl ethers, polyoxyethylene of alkyl phenyl ether-formalin condensates, polyoxyethylene polyoxypropylene block copolymers, polyoxystyrene polyoxyethylene block copolymers, polyether ethylene polyoxyethyleneoxyethyleneoxyethyleneoxyethyleneoxyethyleneoxyethyleneoxy fatty acid, benzyl polyalkylene phenyl ethers, sterile polyoxyalkylene phenyl ethers, acetylene diols, acetylene diols with polyoxyalkylene added, polyoxyethylene ether silicones, polyoxyethylene ester silicones, fluorine surfactants, oil polyoxyethylene that of castor, polyoxyethylene of hydrogenated castor oil and the like; anionic surfactants, such as alkyl sulphate salts, alkyl ether polyoxyethylene sulphate salts, alkyl phenyl ether polyoxyethylene sulphate salts, sterile phenyl ether polyoxyethylene sulphate salts, alkylbenzenesulphonate salts, alkylaryl sulphonate salts, lignin-sulfonate salts, alkylsulfosuccinate salts, naphthalenesulfonate salts, alkylnaphthalenesulfonate salts, naphthalenesulfonic acid formalin condensate salts, alkylnaphthalosulfonic acid formalin condensate salts, polycarbonate salts, polycarbonate salts N-methyl fatty acid, resinates, alkyl ether polyoxyethylene phosphate salts, alkyl phenyl ether polyoxyethylene phosphate salts and the like; cationic surfactants, such as laurylamine hydrochloride salts, stearylamine hydrochloride salts, oleylamine hydrochloride salts, stearylamine acetate salts, stearylaminopropylamine acetate salts, alkylamine salts, including alkyl trimethylammonium chloride and alkenyl chloride; tension 128/150 ampholytic agents, such as amino acid or betaine surfactants and the like. These surfactants can be used individually or in a mixture of two or more types of them. [0129] Examples of the binder and tackifier include carboxy methyl cellulose or a salt thereof, dextrin, water soluble starch, xanthan gum, guar gum, sucrose, polyvinylpyrrolidone, arabic gum, polyvinyl alcohol, polyvinyl acetate, polyacrylate sodium, polyethylene glycol having an average molecular weight of 6000 out of 20,000, polyethylene oxide having an average molecular weight of 100,000 to 5,000,000, phospholipids (eg, lecithin or cephaline), cellulose powder, dextrin, processed starch, composed of polyamino carboxylic acid chelate, cross-linked polyvinylpyrrolidone, styrene-maleic acid copolymer, (meth) acrylic acid copolymer, polyhydric alcohol ester medium and dicarboxylic anhydride, water-soluble polystyrene sulfonic acid, paraffin, terpene, polyamide resin , polyacrylic acid salt, polyoxyethylene, wax, polyvinylalkyl ether, formaldehyde / alkylphenol condensates and synthetic resin emulsion and the like. [0130] Examples of the thickener include water-soluble polymers, such as xanthan gum, guar gum, diutan gum, carboxy methyl cellulose, polyvinylpyrrolidone, a vinyl carboxy polymer, an acrylic polymer, a starch derivative and a polysaccharide; fine inorganic powders, such as high purity bentonite and fumigated silica (white carbon) and the like. [0131] Examples of the dye include inorganic pigments, such as iron oxide, titanium oxide and Prussian blue; organic dyes, such as an alizarin dye, azo dyes and metal phthalocyanine dye and the like. [0132] Examples of the antifreeze agent include polyvalent alcohols, such as ethylene glycol, diethylene glycol, propylene glycol, glycol 129/150 cerol and the like. [0133] Examples of auxiliaries for disintegration or anti-agglomeration include polysaccharides (e.g. starch, alginic acid, mannose and galactose), polyvinylpyrrolidone, fumigated silica (white carbon), ester gum, petroleum resin, sodium tripolyphosphate, sodium hexametaphosphate, metal stearate, cellulose powder, dextrin, methacrylic acid ester copolymer, polyvinylpyrrolidone, polyamine carboxylic acid chelate compound, sulfonated maleic-styrene isobutylene anhydride copolymer and graft copolymer of starch-polyacrylonitrile and the like. [0134] Examples of stabilizing agent include drying agents, such as zeolite, calcined lime and magnesium oxide; antioxidants, such as phenolic compounds, amine compounds, sulfur compounds, phosphoric acid compounds and the like; ultraviolet absorbers, such as salicylic acid compounds, benzophenone compounds and the like. [0135] Examples of the preservative include potassium sorbate, 1,2benzothiazolin-3-one and the like. [0136] In addition, if necessary, functional dispersing agents, active promoters, such as the metabolic decomposition inhibitor piperonyl butoxide, antifreeze agents, such as propylene glycol, anti-oxidation agents, such as BHT, ultraviolet absorbers and others auxiliaries can also be used. [0137] The content of the compound as an active ingredient can be varied as required and the compound as an active ingredient can be used in a proportion properly chosen in the range of 0.01 to 90 parts by weight per 100 parts of the agricultural agents of the present invention. For example, in powders, granules, emulsion or wetting powders, suitable contents of the compound as an active ingredient are 0.01 to 50 parts by weight (0.01 to 50% by weight of the total weight of the 130/150 agricultural insecticide). [0138] The applicable dosage of the agricultural insecticide of the present invention varies, depending on several factors, such as the purpose, the insect pests to be controlled, the growth state of a plant, the tendency of insect pests to appear, time , environmental conditions, form of the preparation, method of application, place of application and time of application. It can be suitably chosen in the range of 0.001 g to 10 kg, preferably 0.01 g to 1 kg (in terms of the compound as an active ingredient) by 10 agres, depending on the purpose. [0139] The agricultural insecticide of the present invention can be used in mixture with other insecticides, acaricides, nematicides, fungicides, agricultural biotic pesticides or similar to expand the spectrum of controllable insect diseases and pests and the time period when effective application is possible or reduce the dosage. In addition, the agricultural insecticide of the present invention can be used in admixture with herbicides, plant growth regulators, fertilizers or the like, depending on the application situation. [0140] Examples of other insecticides, acaricides and agricultural nematicides to be used for this purpose include 3,5-xylyl methylcarbamate (XMC), crystal protein toxin produced by Bacillus thuringienses aizawai, Bacillus thuringienses israelensis, Bacillus thuringienses japonensis, Bacillus thuringienses kurstaki, Bacillus thuringienses tenebrionis or Bacillus thuringienses, BPMC, Bt toxin insecticidal compound, CPCBS (chlorfenson), DCIP (dichlorodiisopropyl ether), DD (1,3-Dichloropropene), DDT, NAC, O-diethyl phosphorothio O-4dimethylsulfamoylphenyl (DSP), O-ethyl-O-4-nitrophenylphenylphosphonothioate (EPN), tripropylisocyanurate (TPIC), acrinatrine, azadiractin, azinphosmethyl, acequinocyl, acetamiprid, acetoprine, amide, amide, amide, amide, amide, amide, amide, amide, amide, amide, amide, amide, amide; , alanycarb, aldicarb, aldoxycarb, 131/150 aldrin, alpha-endosulfan, alpha-cypermethrin, albendazole, aletrine, isazophos, isamidophones, isoamidofos, isoxathione, isofenphos, isoprocarb: MIPC, ivermectin, imicyafos, imidacloprid, etiprotoxin, etiprotoxin, etiprotamine, etiprotamine, etiprotamine, etiprotamine, etiprotamine, , ethofenprox, ethoprophos, etrimphos, emamectin, emamectin-benzoate, endosulfan, empentrine, oxamyl, oxydemeton-methyl, oxydeprofos: ESP, oxybendazole, oxfendazole, potassium oleate, sodium oleate, carbosulfan, carbosulfan, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamino, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbamide, carbide, carbamide, -cialothrin, xylylcarb, quinalphos, quinoprene, chinomethionat, cloethocarb, clothianidin, clofentezine, chromafenozide, chlorantraniliprola, chlorethoxyfos, chlordimeform, chlordime, chlorpyrifos, chlorpyrifos, chlorpyrifos, chloro, chloro, chloro : CYAP, diafenthiuron, diamidafos, cyantraniliprola, theta-cypermethrin, dienochlor, cyienopirafen, dioxabenzofos, diofenolan, sigma-cypermethrin, diclofentiona: ECP, cycloprotrine, dichlorvos: DDVP, disulfoton, dinotefuran, cyhalothrin, cyphenothrin, cyfluthrin, diflubenzuron, cyflumetofen, diflovidazine, cyiexatin, cypermethrin, dimethylamine, spinethyl, dimethylvinphine, dimethylvinphyl spirotetramat, spiromesifene, sulfluramid, sulprofos, sulfoxaflor, zeta-cypermethrin, diazinone, taufluvalinate, dazomet, thiacloprid, thiamethoxam, thiodicarb, thiocyclam, thiosultap, thiosultap-sodium, thionetetet, tetramine, thietronetet, tetramine, thiometon, tebupirimfos, tebufenozida, tebufenpyrad, teflutrina, teflubenzuron, demeton-Smetila, temephos, deltamethrin, terbufos, tralopyril, tralometrine, transflutrina, triazamato, triazuron, netron, trichamon, triclamida, trichamon noviflumuron, hydroprene, vaniliprola, vamidothione, parathione, parathione-methyl, halfenprox, halofenozide, bistrifluron, bisultap, hydramethylnone, hydroxy propyl starch, binapacryl, biphenazate, bifenthrin, pymetrozine, pyraclor 132/150 fos, pirafluprola, pyridafentiona, pyridaben, pyridalyl, pyrifluquinazone, pyriprola, pyriproxyphene, pyrimicarb, pyrimidifene, pyrimiphos-methyl, pyrethrins, fipronil, fenazaquin, fenamiphos, bromopropylate, fenphenotha, , fentiona: MPP, fentoate: PAP, fenvalerate, fenpyroximate, fenpropatrin, fenbendazola, fostiazato, formetanato, butathiofos, buprofezina, furathiocarb, praletrina, fluacrypyrim, fluazufen, fluazurone, fluensulfone, flucyoxin, flucyclurin , flufenoprox, fluproxifene, flubrocitrinate, flubendiamide, flumetrin, flurimfene, prothiofos, protrifenbuta, flonicamid, propaphos, propargita: BPPS, profenofos, proflutrina, propoxur: PHC, bromopropylin, hematoxyl, hexafloxin, hexaflur , bensultap, benzoxide, benfuracarb, phoxim, fosalone, fostiazate, fostietane, phosphamidone , phosphocarb, phosmet: PMP, polynactins, formethanate, formothionate, phorate, industrial oil, malathion, milbemycin, milbemycin-A, milbemectin, mecarbam, mesulfenphos, methomyl, metallomide, metaflumizone, methamidophos, metam-ammonium, metam-sodium, metam-sodium, metam-sodium, metam-sodium, metam-sodium, methydathione: DMTP, methylisothiocyanate, methylneodecanamide, methylparathione, methoxyadiazone, methoxychlor, methoxyfenozide, metoflutrin, methoprene, metolcarb, meperflutrine, mevinphos, monocrotophos, monosultap, lambda-chloramine, rotamine, rhodamine, rhodamine, rhodamine, rhodamine fenbutatin, morantel tartrate, methyl bromide, cyiexatin, calcium cyanamide, calcium polysulfide, sulfur, nicotine sulfate and the like. [0141] Examples of agricultural fungicides to be used for the same purpose as above include soil fungicides, such as aureofungin, azaconazole, azithiram, acypetacs, acibenzolar, acibenzolar-S-methyl, azoxystrobin, anilazine, amisulbrom, ampropylfos, ametoctradine, allyl alcohol, aldimorph, amobam, isothianyl, isova 133/150 lediona, isopyrazam, isoprothiolane, ipconazola, iprodione, iprovalicarb, iprobenfos, imazalil, iminoctadine, iminoctadine-albesilate, iminoctadine-triacetate, imibenconazola, uniconazola, eticonazole, eticonazola-et, equin, eicon, eicon , etridiazole, enestroburin, epoxiconazole, oxadixyl, oxycarboxine, copper 8quinolinolate, oxytetracycline, copper oxinate, oxpoconazole, oxpoconazole-fumarate, oxolinic acid, octilinone, offurace, orisastrobin, metam-sodium, carbamydram, and carbam, carbamide, kammad, carbam and carbam carboxine, carvone, quinazamid, quinacetol, quinoxyphene, quinomethionate, captafol, captan, kiralaxyl, quinconazola, quintozene, guazatin, cufraneb, cuprobam, gliodine, griseofulvin, climbazola, cresol, kresoxim-methyl, clozzone, clozolin, clozolin chlorquinox, chloropicrin, chlorphenazole, chlorodinitronaphthalene, chlorothalonil, chloroneb, zarilamid, salicylanilide, cyazofa mid, diethyl pyrocarbonate, diethofencarb, cyclafuramid, diclocymet, diclozoline, diclobutrazol, dichlofluanid, cycloheximide, diclomezine, dicloran, dichlorophene, diclone, disulfiram, ditalimphos, dithianone, diniconazone, diniconazone, diniconazole, dinicon dinoterbon, dinobuton, dinopenton, dipyrithione, diphenylamine, diphenoconazole, cyflufenamid, diflumetorim, cyproconazola, cyprodinil, cyprofuram, cipendazola, simeconazola, dimethirimol, dimethomorph, cymoxanil, dimoxystromine, siloxamine, zirconium, zirconium zoxamide, dazomet, thiadiazine, thiadinil, thiadifluor, thiabendazola, tioxymid, thiochlorfenphim, thiophanate, thiophanate-methyl, ticiofen, thioquinox, chinomethionat, tifluzamide, thiram, decafentin, tincid, tachydracetone, tachydazacetan, tachydac, , dodicin, dodine, dodecylbenzenesulfonic acid, copper (II) bisethylenediamine (DBEDC), dodem orph, drazoxolon, triadimenol, triadimefon, triazbutyl, triazoxide, triamiphos, triarimol, triclamide, tricyclazole, tritico 134/150 nazola, tridemorph, tributyltin oxide, triflumizole, trifloxystrobin, triforin, tolylfluanid, tolclofos-methyl, natamycin, nabam, nitrotalisopropyl, nitrostirene, nuarimol, nonylphenol sulfonate, copper, halachinine, valine, halachyrinate, validated , picobenzamide, bithionol, bitertanol, hydroxy-isoxazole, hydroisoxazole-potassium, binapacryl, biphenyl, piperalin, himexazola, piraoxystrobin, piracarbolide, piraclostrobina, pyrazophos, pirametroxy, pyrophenyl, pyridine, pyrene, pyrene, pyrene, pyrene , famoxadone, fenapanil, fenamidone, fenaminosulf, fenarimol, fenitropan, fenoxanil, ferinzone, ferbam, fentina, fenpiclonil, fenpyazamine, fenbuconazola, fenfuram, fenpropidine, fenpropimorph, fenhexamid, phthalide, butyramide, butyamide, butybutha, bromide, butyamide, butyramide , furalaxyl, fluacrypyrim, fluazinam, fluoxastrobin, fluotrimazole, fluopico lida, fluopyram, fluoroimide, furcarbanil, fluxapyroxad, fluquinconazola, furconazola, furconazola-cis, fludioxonil, flusilazola, flusulfamide, flutianil, flutolanil, flutriafol, furfural, furmecyclox, flumetover, flumorph, procumoraz, proquinazid, procquinaz, proquinazid propiconazole, propineb, furophanate, probenazola, bromuconazola, hexachlorobutadiene, hexaconazola, hexylthiofos, betoxazina, benalaxyl, benalaxyl-M, benodanil, benomyl, pefurazoate, benquinox, penconazola, benzamorf, bencyzentan, bencyzent, pencycent , penthiopyrad, penflufen, boscalid, phosdifene, fosetyl, fosetyl-Al, polyoxins, polyoxorim, polycarbamate, folpet, formaldehyde, industrial oil, maneb, mancozeb, mandipropamid, miclozoline, myclobutanil, methomycin, methazine, methazhar, mechazon, meczzam metam-sodium, metalaxyl, metalaxyl-M, metiram, methyl isothiocyanate, mepthyldinocap, metconazole, metsulfova x, methfuroxam, metominostrobin, metrafenone, mepanipyrim, mefenoxam, meptyldinocap, mepronil, mebenil, iodomethane, rabenzazole, chloride 135/150 benzalkonium, basic copper chloride, inorganic antimicrobial agents, such as basic copper sulfate, silver and the like, sodium hypochlorite, cupric hydroxide, moisturable sulfur, calcium polysulfides, potassium hydrogen carbonate, sodium hydrogen carbonate, sulfur, copper sulfate anhydride, nickel dimethyldithiocarbamate, copper compounds, such as copper oxime, zinc sulfate, copper sulfate pentahydrate and the like. [0142] Similarly, examples of the herbicide include 1naphthylacetamide, 2,4-PA, 2,3,6-TBA, 2,4,5-T, 2,4,5-TB, 2,4-D, 2,4 -DB, 2,4-DEB, 2,4-DEP, 3,4-DA, 3,4-DB, 3,4-DP, 4-CPA, 4-CPB, 4-CPP, MCP, MCPA, MCPA thioethyl, MCPB , ioxinyl, aclonifen, azafenidin, acifluorfen, aziprotrine, azimsulfuron, asulam, acetochlor, atrazine, atraton, anisuron, anilofos, aviglycine, abscisic acid, amicarbazone, amidosulfuron, amitrola, aminocyclopyrachlor, aminocyclopyrachlor alachlor, allidochlor, alloxydim, alorac, isouron, isocarbamid, isoxaclortola, isoxapyrifop, isoxaflutola, isoxaben, isocil, isonoruron, isoproturon, isopropalin, isopolinate, isometiozine, iodine, iodine, ipanamide, imazon, ipazim, azam imazamethabenz-methyl, imazamox, imazethapyr, imazosulfuron, indaziflam, indanofan, indolabutyric acid, uniconazola-P, eglinazine, esprocarb, ethametsulfuron, ethametsulfuron-methyl, etalfluraline, etiolate, ethoxy, ethoxy, ethoxy, ethoxy, ethoxy, ethoxy, ethoxy etofumesat etobenzanid, epronaz, erbon, endothal, oxadiazon, oxadiargila, oxaziclomefona, oxasulfuron, oxapirazone, oxifluorfen, orizalina, orthosulfamuron, orbencarb, cafenstrola, cambendichlor, carbasulam, carfentrazone, carfentrazone, carfentrazone, carfentrazone, carfentrazone, carfentrazone P, quizalofop-ethyl, xylachlor, quinoclamine, quinonamid, quinclorac, quinmerac, cumyluron, cliodinate, glyphosate, glufosinate, glufosinate-P, credazine, cletho 136/150 dim, cloxyfonac, clodinafop, clodinafop-propargila, chlorotoluron, clopyralid, cloproxydim, cloprop, chlorbromuron, clofop, clomazone, clomethoxylil, clomethoxyfen, clomeprop, chlorazifop, chloramine, chloramine, chloramine, chloramide , chlorimuron-ethyl, chlorsulfuron, clortal, chlorthiamid, chlortoluron, chlornitrofen, chlorfenac, chlorfenprop, chlorbufam, chlorflurazola, chlorflurenol, chlorprocarb, chlorpropham, chlormequat, chloreturon, chloroxinil, chloroxuron, chloroxuron, chloroxuron, chloroxuron, chloroxuron, chloroxuron , dicamba, cycluron, cycloate, cycloxydim, diclosulam, cyclosulfamuron, dichlorprop, dichlorprop-P, dichlobenil, diclofop, diclofop-methyl, dichlormate, dichloralurea, diquat, cisanilide, disul, siduron, dithiopyrine, dinitramine, dinithyline , dinoseb, dinoterb, dinofenate, dinoprop, cyhalofop-butyl, diphenamid, diphenoxuron, diphenopenten, difenzoquat, cybutrin, cyprazine, cyprazole, diflufenican, diflufenzopyr, dipropetrin, cypromid, cyperquat, gibberelin, simazine, dimexane, dimethachlor, dimidazon, dimetamethrin, dimethenamid, simetrin, simeton, dimepiperate, dimefuron, sulfone, sulfone, sulfone, sulfone, sulfone, sulfone, sulfone, sulfone sulfometuron-methyl, secbumeton, sethoxydim, sebutilazine, terbacil, daimuron, dazomet, dalapon, thiazafluron, thiazopyr, tiencarbazone, tiencarbazone-methyl, tiocarbazil, tioclorim, thiobencar, thidiazem, thidiazimin, thidiazimin, thidiazimin tebutam, tebuthiuron, terbumeton, tepraloxydim, tefuriltrione, tembotrione, delachlor, terbacil, terbucarb, terbuchlor, terbutilazine, terbutrina, topramezone, trialkoxydim, triaziflam, triasulfuron, trifluoro, trichloride, tri- triflusulfuron-methyl, trifluralin, trifloxysulfuron, tripropindan, tribenuron-methyl, tribenuron, trifop, trifopsima, trimeturon, naptalam, naproanilide, napropamide, nicosulfuron, nitralin, nitrophen, nitrofluorphene, nipyraclofen, neburon, 137/150 norflurazon, noruron, barban, paclobutrazol, paraquat, parafluron, haloxidine, haloxyfop, haloxyfop-P, haloxyfop-methyl, halosaphen, halosulfuron, halosulfuron-methyl, picloram, picolinafen, bicyclopon, bicyclopon , bifenox, piperophos, himexazola, piraclonila, pirasulfotola, pyrazoxifene, pirazosulfuron, pirazosulfuron-ethyl, pyrazolate, bilanafos, piraflufeno-ethyl, pyriclor, pyridafol, pyrithiobac, pyrithiobac-pyrimyr, pyrimyryr, pyridimyr, pyridatyr, pyridatyrid, pyridatyr, pyridobyrid, pyridimyr, pyridimyr, pyridimyryr -methyl, pyroxsulfone, pyroxsulam, fenasulam, phenisopham, fenuron, phenoxasulfone, fenoxaprop, fenoxaprop-P, phenoxaprop-ethyl, phenothiola, fenoprop, phenobenzurone, fenthiaprop, phenteracol, fentrazamide, phenmedipam, butamphenyl, phenachar, phenachar, phenachar, phenachar, phenam, , butidazole, butylate, buturon, butenachlor, butroxydim, butralin, flazasulfuron, flamprop, furyloxifene, prynachlor, primisulfuron-methyl, fluazifo p, fluazifop-P, fluazifop-butyl, fluazolate, fluroxypyr, fluothiuron, fluometuron, fluoroglycofen, fluorochloridone, fluorodiphene, fluoronitrophen, fluoromidine, flucarbazone, flucarbazone, flucloron, flaceturethane, flaceturetone, fluceturon, flufenpyr, flupropacil, flupropanate, flupoxam, flumioxazin, flumiclorac, flumiclorac-pentila, flumipropine, flumezine, fluometuron, flumetsulam, fluridone, flurtamone, fluroxypyr, pretilachlor, proxan, proglinazine, proslinizina, proslinizina, proslinina, proslinina propazine, propanyl, propizamide, propisochlor, prohydrojasmona, propyrisulfuron, propham, profluazola, profluralin, prohexadione-calcium, propoxycarbazone, propoxycarbazonasodium, profoxydim, bromacil, brompirazone, promethine, prometon, bromoxynil, bromoxynil, bromoxynil, bromoxynil, bromoxynil, bromoxynil, bromoxynil hexachloroacetone, hexazinone, pethoxamid, benazoline, penoxsulam, pebulate, beflubut mid, vernolate, perfluidone, bencarbazone, benzadox, benzipram, benzylaminopurine, benzthiazuron, benzfendizone, 138/150 bensulide, bensulfuron-methyl, benzoylprop, benzobicyclon, benzofenap, benzofluor, bentazone, pentanochlor, benthiocarb, pendimethalin, pentoxazone, benfluralin, benfuresate, phosamine, fomesafen, foramsulfuron, forchloropen, mechazone mesosulfuron, mesosulfuron-methyl, mesotrione, mesoprazine, methoprotrin, metazachlor, metazola, metazosulfuron, methabenzthiazuron, metamitron, metamifop, metam, metallopralin, methiuron, metiozoline, methiobencarb, methio-meton, methuron, methoxymethyl, methoxymethyl, methoxon, metobenzuron, methometon, metolachlor, metribuzin, mepiquat-chloride, mefenacet, mefluidide, monalide, monisouron, monuron, monochloroacetic acid, monolinuron, molinate, morfamquat, iodosulfuron, iodosulfuron-methyl-lily, iodobon, iodobon, iodobon, iodobon , rhodetanil, calcium peroxide, methyl bromide and the like. [0143] Like biotic pesticides, the same effect as above can be expected using the agricultural agent of the present invention in mixture, for example, with viral formulations obtained from nuclear Polyhedrosis virus (NPV), Granulose virus (GV) , cytoplasmic polyhedrosis virus (CPV), Entomopox virus (EPV), etc .; microbial pesticides used as nematicides or insecticides, such as Monacrosporium phymatophagum, Steinernema carpocapsae, Steinernema kushidai, Pasteuria penetrans, etc .; microbial pesticides used as fungicides, such as Trichoderma lignorum, Agrobacterium radiobacter, non-pathogenic Erwinia carotovora, Bacillus subtilis, etc .; and biotic pesticides used as herbicides, such as Xanthomonas campestris, etc. [0144] In addition, the agricultural agent of the present invention can be used in combination with biotic pesticides, including natural enemies, such as parasitic wasp (Encarsia formosa), parasitic wasp 139/150 tica (Aphidius colemaní), galling mosquito (Aphidoletes aphidimyza), parasitic wasp (Diglyphus isaea), parasitic mite (Dacnusa sibirica), predatory mite (Phytoseiulus persimilis), predatory mite (Amblyseius), predatory snake (amblyseius) , etc.; microbial pesticides, such as Beauveria brongniartii, etc .; and pheromones, such as (Z) -10-tetradecenyl acetate, (E, Z) -4,10-tetradecadienyl acetate, (Z) -8-dodecenyl acetate, (Z) -11-tetradecenyl acetate, ( Z) -13-icosen-10-one, 14-methyl-1-octadecene, etc. [0145] Representative examples of the present invention are shown below, which should not be construed as limiting. Reference Example 1-1. Production of 5-butyl-4-hydroxypyrimidine OH MeO ' [0146] To a solution of sodium methoxide (8.3 g, 154 mmol) in dehydrated tetrahydrofuran (40 mL) was successively added dropwise under an argon atmosphere at 5-10 ° C, ethyl formate (7.4 g, 100 mmol) and hexanoic acid methyl ester (10 g, 77 mmol) and the mixture was stirred at room temperature for 3 hours. To the reaction solution, a solution of formamidine acetate (8.0 g, 77 mmol) in methanol (70 mL) and a 28% solution (16 g, 81 mmol) of sodium methoxide in methanol were added dropwise and the mixture was stirred with heating under reflux for 10 hours. The reaction solution was cooled to room temperature, water (10 ml) was added to dissolve the precipitated salt and the mixture was concentrated under reduced pressure. Concentrated hydrochloric acid (15 ml) was added and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure and purified by silica gel column chromatography to provide 5-n-butyl-4-hydroxypyrimidine (1,3 140/150 g, 11%). Yield: 11% Property: 1 H-NMR (400 MHz, CDCl 3 ): ò 8.05 (s, 1H), 7.85 (s, 1H), 2.50 (t, 2H), 1.65-1.66 (m, 2H), 1.45-1.35 (m, 2H), 0.95 (t, 3H) Reference Example 1-2. Production of 5-butyl-4-chloropyrimidine OH Cl [0147] To a solution of 5-butyl-4-hydroxypyrimidine (1.3 g, 8.5 mmol) produced in the previous production method in toluene (5 mL) was added phosphorus oxychloride (3.9 g, 26 mmol) and the mixture was stirred with heating under reflux for 2 hours. The mixture was cooled to room temperature and concentrated under reduced pressure to remove excess phosphorus oxychloride. The residue was poured into aqueous saturated sodium hydrogen carbonate and the mixture was extracted with MTBE. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to provide 5butyl-4-chloropyrimidine (1.1 g, 76%) as a purified crude product. Yield: 76% Property: 1 H-NMR (400 MHz, CDCl 3 ): ò 8.84 (s, 1H), 8.51 (s, 1H), 2.72 (t, 2H), 1.70-1.60 ( m, 2H), 1.50-1.40 (m, 2H), 0.98 (t, 3H) Example 1. Production of 5-butyl-4- (4-t-butylbenzyloxy) pyrimidine (compound No. 1-7) [0148] To a produced solution of 5-butyl-4-chloropyrimidine (0.20 g, 1.2 mmol) in the previous production method and 4-tbutylbenzyl alcohol (0.19 g, 1.2 mmol) in THF (5 ml) was added at 0 ° C 141/150 sodium hydride (0.051 g, 1.3 mmol) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice water and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to provide 5-butyl4- (4-i-butylbenzyloxy) pyrimidine (0.26 g, 74%). Yield: 74% Property: 1.5360 (27.5 ° C) Reference Example 2-1. Production of 4,6-dichloro-5- (1,3-dioxolan-2-yl) pyrimidine r N r Cl r N r Cl Cl H Cl O ^ S [0149] To a solution of 4,6-dichloro-5-formylapyrimidine (10 g, 56.5 mmol) synthesized with reference to WO2001 / 017975 in toluene (60 ml) were added at room temperature environment, ptoluenesulfonic acid (1 g, 5.65 mmol) and ethylene glycol (7 g, 113 mmol) and the mixture was stirred azeotropically with heating under reflux for 30 min. To the reaction solution, ethyl acetate was added and the mixture was washed with saturated aqueous sodium hydrogen carbonate and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to provide 4,6-dichloro-5- (1,3-dioxolan-2-yl) pyrimidine (8.4 g). Yield: 67% Property: 1 H-NMR (400 MHz, CDCl 3 ): ó 8.75 (s, 1H), 6.37 (s, 1H), 4.28-4.37 (m, 2H), 4.06-4.15 (m, 2H) 142/150 Reference Example 2-2. Production of 6-chloro-4- (4-trifluoromethylbenzyloxy) -5- (1,3-dioxolan-2yl) pyrimidine [0150] To a solution of 4,6-dichloro-5- (1,3-dioxolan-2-yl) pyrimidine (2.0 g, 9.1 mmol) and 4-trifluoromethylbenzyl alcohol (1.8 g, 10 mmol) in DMA (10 ml) was added at 0 ° C sodium hydride (0.43 g, 11 mmol) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice water and the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to provide 6-chloro-4- (4-trifluoromethylbenzyloxy) -5- (1,3-dioxolan- 2-yl) pyrimidine (2.2 g, 67%). Yield: 67% Property: 1 H-NMR (400 MHz, CDCl 3 ): ò 8.53 (s, 1H), 7.64 (d, 2H), 7.53 (d, 2H), 6.34 (s, 1H), 4.15-4.10 (m, 2H), 4.05-3.95 (m, 2H) Example 2. Production of 4- (4-trifluoromethylbenzyloxy) -5- (1,3-dioxolan-2-yl) pyrimidine (Compound No. 4-4) [0151] To a solution of 6-chloro-4- (4-trifluoromethylbenzyloxy) -5- (2dioxolanyl) pyrimidine (2.2 g, 6.1 mmol) in DMA (10 mL) was added under an argon atmosphere , triethylamine (1.0 g, 10 mmol), 143/150 formic acid (0.42 g, 9.1 mmol) and tetrakis (triphenylphosphine) palladium (0.70 g, 0.61 mmol) and the mixture was stirred at 80 ° C for 3 hours. To the reaction solution, water was added and the mixture was extracted with tert-butyl methyl ether. The organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to provide 4- (4-trifluoromethylbenzyloxy) -5- (1,3-dioxolan-2-yl) pyrimidine (0.47 g, 24%). Yield: 24% Property: 38-39 ° C [0152] Formulation examples are shown below, which do not limit the present invention. In the Formulation Examples, part means parts by weight. Formulation Example 1. Compound of the present invention 10 parts Xylene 70 pieces N-methylpyrrolidone 10 parts Mixture of polyoxyethylene nonylphenyl ether and calcium alkylbenzenesulfonate 10 parts [00153] An emulsifiable concentrate is prepared by uniformly mixing the above ingredients to allow dissolution. Formulation Example 2. Compound of the present invention 3 parts Clay powder 82 parts Diatomaceous earth powder 15 parts [00154] A powder is prepared by means of uniform mixing and crushing of the above ingredients. Formulation Example 3. Compound of the present invention 5 parts Bentonite powder and clay mixed 90 parts 144/150 5-part calcium lignin sulfonate [0155] Granules are prepared by mixing the above ingredients evenly and kneading the resulting mixture together with an adequate amount of water, followed by granulation and drying. Formulation Example 4. Compound of the present invention 20 parts Mixture of kaolin and synthetic high dispersion silicic acid 75 parts Mixture of polyoxyethylene nonylphenyl ether and calcium alkylbenzenesulfonates 5 parts [00156] A moistable powder is prepared by uniformly mixing and grinding the above ingredients. Experimental Example 1. Effectiveness of control against green peach aphid (Myzus persicae) [00157] A Chinese cabbage plant was planted in each of 8 cm diameter plastic pots and 8 cm high and green peach aphids were propagated over the plant, after which the aphids in each pot were counted. Each arylalkyloxypyrimidine derivative of the general formula (I) or a salt thereof of the present invention was dispersed and diluted with water to obtain a liquid chemical at 500 ppm. The stems and leaves of the Chinese cabbage plants were sprayed with the liquid chemical and air dried and then the pots were stored in a greenhouse. Six days after spraying, green peach aphids that were fed on the Chinese cabbage plant were counted and the degree of control effectiveness was calculated using the following equation, by which the insecticidal effect was judged according to the criteria shown below. Control effectiveness = 100 - {(T x Ca) / (Ta x C)} x 100 Ta: number of parasites before spraying in the group 145/150 treated, T: number of parasites after spraying in the treated group, Ca: number of parasites before spraying in the untreated group, C: number of parasites after spraying in the untreated group. A · · - 100% control effectiveness B ··· control effectiveness 99% - 90% C ··· control effectiveness 89% - 80% D ··· control effectiveness 79% - 50% Experimental Example 2. Insecticidal effect on brown rice locust (Nilaparvata lugens) [00158] Each arylalkyloxypyrimidine derivative of the general formula (I) or a salt thereof of the present invention was dispersed and diluted with water to obtain a liquid chemical at 500 ppm. Rice seedlings (cultivar: Nihonbare) were immersed in the liquid chemical for 30 seconds and air dried, after which each seedling was placed in a glass test tube and inoculated with nymphs in the 13th stage of brown rice locust and the test tube was capped with a cotton pad. Eight days after inoculation, dead and live locusts were counted. Corrected mortality was calculated using the following equation and the control effect was judged according to the criteria described below. (survival rate (survival rate M or T d to the lid and the untreated group) in the treated group) x 100 = corrected (%) -------------------------- -------------------------- (survival rate in the untreated group) [00159] Diagnostic criteria: same as in Experimental Example 1. 146/150 [0160] As a result, in Experimental Example 1, among the arylalkyloxypyrimidine derivatives of the present invention represented by formula (I), compounds Nos. 1-1, 1-2, 1-3, 1-4, 1-5, 1-7, 18, 1-13, 1-14, 1-21, 1-30, 1-37, 1-40, 1-54, 1-55, 1-70, 1-95, 1-110, 2-2, 2- 3, 2-4, 2-5, 2-7, 2-8, 2-9, 2-13, 2-14, 2-21, 2-30, 2-37, 2-41, 2- 51, 252, 2-54, 2-55, 2-59, 2-62, 2-66, 2-67, 2-73, 2-76, 2-77, 2-87, 2-88, 295, 2-97, 2-100, 2-102, 2-103, 2-104, 2-107, 2-108, 3-2, 3-3, 3-4, 3-5, 3- 7, 3-8, 3-9, 3-13, 3-14, 3-21, 3-31, 3-37, 3-51, 3-52, 3-67, 3-68, 3- 78, 3- 95, 3-111, 4-1, 4-3, 4-4, 4-6, 4-9, 4-10, 4-18, 4-19, 4-20, 4-21, 4- 22, 4- 23, 4-26, 4-28, 4-31, 4-33, 4-38, 4-40, 4-41, 4-42, 4-43, 4-45, 4-46, 447, 4-51, 4-52, 4-53, 4-56, 4-57, 4-63, 4-66, 4-67, 4-68, 4-71, 4-72, 478, 4-81, 4-82, 4-86, 4-88, 4-89, 4-90, 5-1, 5-2, 5-3, 7-52, 8-1, 8-2, 8-5, 8- 7, 8-8, 8-9, 8-10, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 8-22, 8-23, 8-24, 8-26, 8-27, 8-28, 8-29, 8-31, 8-32, 8-34, 8-35, 8- 37, 8-39, 8-40, 8-42, 8-49, 8-50, 8-51, 8-52, 8-53, 8-54, 8-57 8-58 , 8- 59, 8-60, 8-61, 8-62, 8-63, 8-64, 9-2, 9-3, 9-6, 9-7 9-10 9-11 , 9-12 , 9- 13, 9-14, 9-18, 9-19, 9-20, 9-21, 9-25, 9-26, 9-27, 9-28, 9-29 9-31 , 9- 32, 9-33, 9-34, 9-41, 9-42, 9-43, 9-44, 9-45, 9-46, 10-1, 10-2, 10-3, 10- 4, 10-5, 10-6, 10-7, 10-8, 10-9, 10-10, 10-11, 12-3, 12-4, 12-5, 12-10, 12-11, 12-12, 12-13, 12-19, 12-20, 12-23, 14-2, 14-3, 14-5, 14-8, 14- 10, 14-11, 14-12, 14-13, 14-14, 14-15, 14-16, 14-17, 14-18 14-19, 14- 20, 14-23, 14-25, 14-27, 14-41, 14-44, 14-46, 14-47, 14-49 14-50, 14- 52, 14-52, 14-54, 14-55, 14-56, 14-57, 14-60, 14-64, 14-65 14-66, 14- 86, 14-90, 14-98, 14-102 , 14-104, 14-105, 14-106, 14-112, 14-117, 14- 118, 14-119, 14-120, 14-121, 14-122, 14-123, 15-1, 15-2, 15-4, 15-5, 15-6, 15-8 15-9, 15-10, 15-11, 15-12, 15-13, 15-14, 15-15, 15-16, 15- 17, 15-22, 15-24, 15-27, 15-29, 15-30, 15-31, 15-33, 15-34, 15-40, 15- 43, 15-44, 15-45, 15-46, 15-47, 15-52, 15-60, 15-61, 15-62, 15-63, 15- 65, 15-74, 15-75, 15-76, 15-77, 15-78, 15-81, 15-83, 15-84, 15-86, 15- 87, 15-88, 15-90, 15-91, 15-92, 15-93, 15-94, 15-95, 15-96, 15-97, 15- 147/150 101, 15-106, 15-108, 15-110, 15-113 and 15-114 showed insecticidal effects of no less than D against green peach aphid and, particularly, compounds 1-1, 1-2, 1 -4, 1-5, 1-7, 1-8, 1-13, 1-37, 2-3, 2-4, 2-7, 2-8, 2-9, 2-13, 2-21 , 2-30, 2-37, 2-54, 2-59, 2-100, 2-104, 2107, 3-2, 3-3, 3-5, 3-7, 3-8, 3-9 , 3-21, 3-37, 3-52, 3-67, 3-68, 3-78, 395, 4-1, 4-3, 4-4, 4-9, 4-19, 4-20 , 4-23, 4-31, 4-33, 4-38, 4-41, 4-46, 447, 4-51, 4-52, 4-56, 4-57, 4-63, 4-66 , 4-67, 4-72, 4-78, 4-81, 4-82, 5-3, 7- 52, 8-7, 8-8, 8-14, 8-18, 8-19, 8-22, 8-26, 8-27, 8-28, 8-31, 8-32, 837, 8-39, 8-49, 8-59, 8-63, 9-3, 9-10, 9-11, 9-19, 9-25, 9-33, 9-34, 9-43, 9- 45, 10-1, 10-4, 10-5, 10-6, 10-8, 10-9, 14-5, 14-10, 14-12, 14-15, 1417, 14-23, 14- 25, 14-46, 14-47, 14-49, 14-50, 14-52, 14-54, 14-60, 14102, 14-104, 14-105, 14-117, 14-118, 14- 119, 14-120, 14-121, 14-122, 15-2, 15-4, 15-11, 15-12, 15-14, 15-22, 15-27, 15-33, 15-60, 15-61, 1562, 15-75, 15-76, 15-77, 15-78, 15-84, 15-86, 15-87, 15-88, 15-90, 1592, 15-93, 15- 110 and 15-114 showed a superior insecticidal effect of A. [0161] Furthermore, in Experimental Example 2, among the arylalkyloxypyrimidine derivatives of the present invention represented by formula (I), compounds Nos. 1-1, 1-2, 1-3, 1-4, 1-5, 1-7, 1-8, 1-9, 113, 1-14, 1-21, 1-30, 1-31, 1-37, 1-40, 1-52, 1-54, 1-55, 1-72, 1-100, 22, 2-3, 2-4, 2-5, 2-7, 2-8, 2-9, 2-13, 2-14, 2-21, 2-30, 2-31, 2-37, 2-41, 2-52, 2-54, 2-55, 2-57, 2- 66, 2-67, 2-73, 2-76, 2-87, 2-95, 2-97, 2-100, 2- 105, 2-107, 2-108, 3-2, 3-3, 3-4, 3-5, 3-7, 3-8, 3-9, 3-13, 3-14, 3- 21, 3- 37, 3-52, 3-67, 3-68, 3-78, 3-88, 3-95, 4-1, 4-3, 4-4, 4-6, 4-9, 4- 10, 416, 4-18, 4-19, 4-20, 4-21, 4-22, 4-28, 4-31, 4-38, 4-40, 4-41, 4-42, 443, 4-44, 4-45, 4-51, 4-52, 4-53, 4-56, 4-57, 4-63, 4-66, 4-67, 4-68, 471, 4-72, 4-78, 4-81, 4-82, 5-1, 5-2, 5-3, 7-52, 8-2, 8-5, 8-6, 8-7, 8-8, 89, 8-10, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-22, 8-23, 8-24, 8-26, 8- 28, 8-29, 8-31, 8-32, 8-33, 8-34, 8-35, 8-36, 8-37, 8-39, 8-40, 8-45, 847, 8-49, 8-52, 8-53, 8-54, 8-58, 8-59, 8-60, 8-63, 8-64, 9-1, 9-2, 9-3, 94, 9-6, 9-9, 9-10, 9-11, 9-12, 9-18, 9-19, 9-20, 9-21, 9-22, 9-25, 9-26, 9148 / 150 31, 9-32, 9-33, 9-35, 9-36, 9-38, 9-39, 9-40, 9-42, 9-43, 9-45, 9-47, ΙΟΙ, 10- 2, 10-3, 10-4, 10-5, 10-6, 10-7, 10-8, 10-10, 10-11, 14-1, 14-5, 14-9, 14-10, 14-11, 14-12, 14-13, 14-14, 14-16, 14-17, 14-18, 14-19 14-20 14-22, 14-25, 14-27, 14-29, 14-36, 14-37, 14-39, 14-40, 14-41 14-43 14-44, 14-46, 14-47, 14-49, 14-50, 14-51, 14-52, 14-53, 14-54 14-55 14-56, 14-57, 14-58, 14-59, 14-60, 14-62, 14-63, 14-65, 14-67 14-69, 14-86, 14-102, 14-103, 14-104, 14-105, 14-106, 14-109, 14116, 14-117, 14-118, 14-119, 14-120, 14-121, 14-122, 14-123, 15-1, 15-2, 15-4, 1 5-5, 15 -6, 15-7, 15-8, 15-9, 15-10, 15-11, 15-12, 15-13, 15-14, 15-15, 15-16, 15-17, 15-19, 15-20, 15-21, 15-22, 15-23, 15-24, 15-25, 15-26, 15-28, 15-29, 15-30, 15-31, 15-34, 15-35, 15-36, 15-37, 15-38, 15-39, 15-40, 15-41, 15-46, 15-47, 15-48, 15-49, 15-50, 15-52, 15-53, 15-54, 15-55, 15-56, 15-57, 15-58, 15-59, 15-60, 15-61, 15-62, 15-63, 15-64, 15-66, 15-67, 15-70, 15-71, 15-72, 15-75, 15-76, 15-77, 15-78, 15-79, 15-80, 15-81, 15-83, 15-84, 15-85, 15-86, 15-87, 15-88, 15-90, 15-91, 15-92, 15-93, 15-95, 15-97, 15-100 , 15-10 6, 15-1 09, 15- 110, 15-111, 15-112, 5-113 and 15-114 showed an insecticidal effect of no less than D against brown rice locust and, particularly, compounds 1-1, 1-2, 1-3, 1-4, 1-5, 1-7, 1-8, 1-9, 1-13, 121, 1-30, 1-37, 1-40, 1-54, 1-55, 1-72, 1-100, 2-2, 2-3, 2-4, 2-5, 2-7, 28, 2-9, 2-13, 2-14, 2-21, 2-30, 2-37, 2-41, 2-54, 2-55, 2-67, 2-73, 2-87, 2- 97, 2-100, 2-105, 3-3, 3-4, 3-5, 3-7, 3-8, 3-9, 3-13, 3-14, 3-21, 3- 37, 3- 68, 3-78, 3-95, 4-1, 4-3, 4-4, 4-6, 4-9, 4-16, 4-18, 4-19, 4-20, 4- 21, 422, 4-38, 4-40, 4-41, 4-43, 4-45, 4-53, 4-57, 4-63, 4-66, 4-67, 4-71, 472, 4-78, 5-1, 5-2, 5-3, 8-6, 8-7, 8-8, 8-14, 8-19, 8-22, 8-24, 8-26, 8- 28, 8-29, 8-31, 8-32, 8-34, 8-35, 8-37, 8-39, 8-49, 8-53, 8-59, 8-60, 9-1, 92, 9-3, 9-4, 9-10, 9-18, 9-20, 9-21, 9-22, 9-26, 9-31, 9-32, 9-38, 9-39, 943, 9-47, 10-1, 10-2, 10-3, 10-4, 10-5, 10-6, 10-7, 10-8, 10-10, 10-11, 14-5, 14-10, 14-12, 14-14, 14-20, 14-27, 14-46, 14-47, 14-49, 14-50, 14-52, 14-54, 14-55, 14- 56, 14-60, 14-102, 14-104, 14-105, 14-117, 149/150 14-118, 14-119, 14-120, 14-121, 14-122, 14-123, 15-4, 15-6, 15-10, 15-13, 15-14, 15-31, 15-35, 15-36, 15-39, 15-40, 15-41, 15-47, 15-48, 15-49, 15-52, 15-54, 15-55, 15-56, 15-59, 15-60, 15-61, 15-62, 15-63, 15-77, 15-78, 15-86, 15-88, 15-106, 15-1 10, 15-111, 5-113 and 15-114 showed superior insecticidal effect of A. Experimental Example 3 Acaricidal effect on cattle tick (Haemaphysalis longicornis) [0162] An absorbent cotton was placed on the base of a glass bottle (diameter 3 cm x height 4.5 cm). The arylalkyloxypyrimidine derivative of the present invention represented by formula (I) or a salt thereof was dispersed in water to provide a diluted drug solution (200 ppm). The drug solution (2 ml) was added dropwise. Cattle ticks were inoculated at 5 each and the bottle was capped with a screen. After 4 days since inoculation, dead and live ticks were counted and the corrected mortality was calculated using the following formula and the acaricidal effect was judged according to the criteria of Experimental Example 1. Corrected mortality (%) = (survival rate in the untreated group - survival rate in the treated group) / (survival rate in the untreated group) * 100 [0163] As a result, among the arylalkyloxypyrimidine derivatives of the present invention represented by formula (I), compounds Nos. 1-2, 2-5, 2-37, 2-54, 3-21, 3-111,4-19, 4-41,4-53, 4-67, 822, 8-26, 9-45, 10-7 and 15-78 showed acaricidal effects of not less than D against cattle ticks, and particularly compounds 1-2, 2-5, 2-54, 3-21, 3-111, 4-67 , 9-45 and 15-78 showed superior acaricidal effect of A. INDUSTRIAL APPLICABILITY [0164] The arylalkyloxypyrimidine derivative of the present invention 150/150 or a salt of the same has a superior effect as an agricultural insecticide. On the other hand, the derivative shows an effect on pests that are parasitic on pets, such as dogs and cats, and domestic animals, such as cattle, sheep and the like. [0165] The present application is based on Patent Applications Nos 019768/2012 and 171532/2012 filed in Japan, the contents of which are incorporated herein by reference.
权利要求:
Claims (10) [1] 1. Arylalkyloxypyrimidine derivative, characterized by the fact that it is represented by formula (I): (°) n * N ^ N R 2 R 3 R 1 LÇ> T (X) m (I) where R 1 is (a124) the following structural formula Q 7 , Q 8 or Q 9 Z 2 7 Q 8 Q 7 Q 9 where R 6 and R 7 can be the same or different and each is a hydrogen atom, a (C1-C6) alkyl group, a (C3-C6) cycloalkyl group, a (C2-C6) alkenyl group , a (C2-C6) alkynyl group, a (C3-C6) cycloalkyl (C1-C6) alkyl group, a halo (C1-C6) alkyl group, a halo (C3-C6) cycloalkyl group, a halo (C2 -C6) alkenyl, a halo (C2-C6) alkynyl group, a halo (C3-C6) cycloalkyl (C1C6) alkyl group, a (C1-C6) alkylcarbonyloxy (C1-C6) alkyl group, a (C1-C6) group ) (C1-C6) alkyl alkoxy, a (C1-C6) alkyl hydroxy group, (C2-C6) alkenyloxy (C1-C6) alkyl group, a (C1-C6) alkyl phenoxy group, a (C1-C6) alkyl group ) alkylsulfonyl (C1-C6) alkyl, a (C1-C6) alkylsulfonyloxy (C1-C6) alkyl group, a halogen atom, a phenyl group, a phenyl (C1-C6) alkyl group or a (C1-) group C6) alkylcarbonyl, p is an integer from 0 to 5 and Z 1 and Z 2 can be the same or different and each is a carbon atom, an oxygen atom, S, SO, SO2 or NR 6 where R 6 is in accordance defined above; R 2 and R 3 can be the same or different and each is (b1) a hydrogen atom; or Petition 870180139221, of 10/09/2018, p. 5/17 [2] 2/10 (b6) a halo (C 1 -C 8) alkyl group; q is an integer from 1 to 3; X can be the same or different and each is (c1) a hydrogen atom; (c2) a halogen atom; (c4) a cyano group; (c5) a nitro group; (c10) a CO group (R 4 ) where R 4 is as defined below; (c14) an (C1-C8) alkyl group; (c18) a halo (C1-C8) alkyl group; (c22) a tri (C1-C8) alkylsilyl group in which the alkyls can be the same or different; (c27) an (C1-C8) alkoxy group; (c31) a halo (C1-C8) alkoxy group; (c40) a halo (C1-C8) alkoxy-halo (C1-C8) alkoxy group; (c42) an (C1-C8) alkylthio group; (c46) a halo (C1-C8) alkylthio group; (c76) an aryl group; (c77) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group ( C1C6) alkyl, (e) a halo (C1-C6) alkyl group, (f) a (C1-C6) alkoxy group, (g) a halo (C1-C6) alkoxy group, (h) a (C2- C6) alkenyloxy, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a (C3- C6) cycloalkoxy, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1C6) alkoxy group, (o) a halo (C3-C6) cycloalkyl (C1-C6) group alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1-C6) alkylthio group, (r) a group Petition 870180139221, of 10/09/2018, p. 6/17 [3] 3/10 (C1-C6) alkylsulfinyl, (s) a halo (C1-C6) alkylsulfinyl group, (t) a (C1-Ce) alkylsulfonyl group, (u) a halo (C1-) group C6) alkylsulfonyl, (v) an N (R 4 ) R 5 group in which R 4 and R 5 are as defined below, (w) an N (R 4 ) COR 5 group in which R 4 and R 5 are as defined below, (x) an N (R 4 ) CO2R 5 group where R 4 and R 5 are as defined below, (y) an N (R 4 ) SO2R 5 group where R 4 and R 5 are as defined below, (z) a COR 4 group in which R 4 is as defined below, (aa) a CO2R 4 group in which R 4 is as defined below, (bb) a CON group (R 4 ) R 5 in which R 4 and R 5 are as defined below and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined below; (c78) an aryl (C1-Cs) alkyl group; (c79) an aryl (C1-Cs) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a (C1-Ce) alkyl group, (e) a halo (C1-Ce) alkyl group, (f) a (C1Ce) alkoxy group, (g) a halo (C1-Ce) alkoxy group, (h ) a (C2C6) alkenyloxy group, (i) a (C2-C6) alkenyloxy halo group, (j) an (C2Ce) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a ( C3C6) cycloalkoxy, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3C6) cycloalkyl (C1-C6) alkoxy group, (o) a halo (C3-Ce) cycloalkyl (C1Ce) alkoxy group, (p) an (C1-Ce) alkylthio group, (q) a halo (C1Ce) alkylthio group, (r) a (C1-Ce) alkylsulfinyl group, (s) a halo (C1Ce) alkylsulfinyl group, (t) a (C1-Ce) alkylsulfonyl group, (u) a halo (C1-Ce) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are in accordance defined below, (w) an N (R 4 ) COR 5 group where R 4 and R 5 are as defined below, (x) an N group (R 4 ) CO2R 5 where R 4 and R 5 are as defined below, (y) an N group (R 4 ) SO2R 5 where R 4 and R 5 are as defined below, (z) a COR 4 group in that R 4 is as defined below, (aa) a CO2R 4 group where R 4 is as Petition 870180139221, of 10/09/2018, p. 7/17 [4] 4/10 defined below, (bb) a group CON (R 4 ) R 5 where R 4 and R 5 are as defined below and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined below; (c80) an aryloxy group; or (c81) an aryloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group (C1C6) alkyl, (e) a halo (C1-C6) alkyl group, (f) a (C1-C6) alkoxy group, (g) a halo (C1-C6) alkoxy group, (h) a (C2 -C6) alkenyloxy, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a (C3 -C6) cycloalkoxy, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1C6) alkoxy group, (o) a halo (C3-C6) cycloalkyl (C1-C6) group ) alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1-C6) alkylthio group, (r) a (C1-C6) alkylsulfinyl group, (s) a halo (C1) group -C6) alkylsulfinyl, (t) a (C1-C6) alkylsulfonyl group, (u) a halo (C1-C6) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined below, (w) a group N (R 4 ) COR 5 where R 4 and R 5 are as defined below, (x) a group N ( R 4 ) CO2R 5 where R 4 and R 5 are as defined below, (y) an N (R 4 ) SO2R 5 group where R 4 and R 5 are as defined below, (z) a COR 4 group where R 4 is as defined below, (aa) a CO2R 4 group in which R 4 is as defined below, (bb) a CON group (R 4 ) R 5 in which R 4 and R 5 are as defined below and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined below; R 4 and R 5 can be the same or different and each is (i) a hydrogen atom, (ii) a (C1-C6) alkyl group, (iii) a (C3-C6) cycloalkyl group, (iv) an (C2-C6) alkenyl group, (v) an (C2C6) alkynyl group, (vi) a (C3-C6) cycloalkyl (C1-C6) alkyl group, (vii) a halo (C1-C6) alkyl group, (viii) a halo (C3-C6) cycloalkyl group, (ix) a Petition 870180139221, of 10/09/2018, p. 8/17 [5] 5/10 (C2-C6) alkenyl halo group, (x) a (C2-Ce) alkynyl halo group, (xi) a (C3-C6) cycloalkyl (C1-C6) alkyl group, (xii) a ( C1-Cs) alkylsulfonyl, (xiii) a (C1-C6) alkylcarbonyl group, (xiv) a halo (C1C6) alkylcarbonyl group, (xv) an (C1-C6) alkoxycarbonyl group, (xvi) a (C3-C6) group ) cycloalkylcarbonyl, (xvii) a phenyl group, (xviii) a phenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) an (C1Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, (d) a (C1-Ce) alkoxy group, (e) a halo (C1-Ce) alkoxy group and (f) a phenoxy group, (xix) a group phenoxyphenyl having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C1-Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, (d) a (C1Ce) alkoxy group and (e) a halo (C1-Ce) alkoxy group, (xx) a (C1C8) alkyl hydroxy group, (xxi) a phenyl (C1-Ce) alkyl group, (xxii) a phenyl (C1Ce) alkyl group t endo, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C1-Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, ( d) a (C1Ce) alkoxy group, (e) a halo (C1-Ce) alkoxy group and (f) a phenoxy group or (xxiii) a phenoxyphenyl (C1-C6) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C1-Ce) alkyl group, (c) a halo (C1Ce) alkyl group, (d) an (C1-Ce) alkoxy group and (e) a halo (C1-Ce) alkoxy group; Y is CH or a nitrogen atom, m is an integer from 0 to 4, n is an integer from 0 or 1 or a salt thereof. 2. Arylalkyloxypyrimidine derivative according to claim 1, characterized by the fact that: R 2 , R 3 , X, R 4 , R 5 , Y, q, men are as defined in claim 1, R 1 is (a124) a structural formula Q 7 , Q 8 or Q 9 wherein each structural formula is as defined in claim 1, Z 1 and Z 2 are one Petition 870180139221, of 10/09/2018, p. 9/17 [6] 6/10 oxygen atom, and other symbols on them are as defined in claim 1 or a salt thereof. 3. Agricultural insecticide, characterized by the fact that it comprises the arylalkyloxypyrimidine derivative as defined in claim 1 or 2 or a salt thereof as an active ingredient. 4. Method of using an agricultural insecticide, characterized by the fact that it comprises treatment of a plant or soil with the arylalkyloxypyrimidine derivative as defined in claim 1 or 2 or a salt thereof. 5. Method of control of an agricultural pest, characterized by the fact that it comprises treatment of a plant or soil with the arylalkyloxypyrimidine derivative as defined in claim 1 or 2 or a salt thereof. 6. Use of the arylalkyloxypyrimidine derivative as defined in claim 1 or 2 or a salt thereof, characterized by the fact that it is as an agricultural insecticide. [7] 7. Use of the arylalkyloxypyrimidine derivative as defined in claim 1 or 2 or a salt thereof, characterized by the fact that it is as a veterinary insecticide. [8] 8. Arylalkyloxypyrimidine derivative, characterized by the fact that it is represented by formula (II): N ^ NR 2 R 3 Hal (X) m (II) where R 1 is (a124) the following structural formula Q 7 , Q 8 or Q 9 Petition 870180139221, of 10/09/2018, p. 10/17 7/10 R6 Z z> R7) pr6 7! ^ ' R ' 1 ' Q 7Q 8 Q 9 where R 6 and R 7 and R 8 can be the same or different and each is a hydrogen atom, a (C-C6) alkyl group, a (C3-C6) cycloalkyl group, a (C2-C6) group alkenyl, an (C2C6) alkynyl group, a (C3-C6) cycloalkyl (C1-C6) alkyl group, a halo (C1-C6) alkyl group, a halo (C3-C6) cycloalkyl group, a halo (C2- C6) alkenyl, a halo (C2-C6) alkynyl group, a halo (C3C6) cycloalkyl (C1-C6) alkyl group, a (C1-C6) alkylcarbonyloxy (C1C6) alkyl group, a (C1-C6) alkoxy group ( C1-C6) alkyl, a hydroxy (C1C6) alkyl group, a (C2-C6) alkenyloxy (C1-C6) alkyl group, a phenoxy (C1-C6) alkyl group, a (C1-C6) alkylsulfonyl ( C1-C6) alkyl, a (C1-C6) alkylsulfonyloxy (C1-C6) alkyl group, a halogen atom, a phenyl group, a phenyl (C1-C6) alkyl group or a (C1C6) alkylcarbonyl group, p is an integer from 0 to 5 and Z 1 and Z 2 can be the same or different and each is a carbon atom, an oxygen atom, S, SO, SO2 or NR 6 where R 6 is as defined inido up R 2 and R 3 can be the same or different and each is (b1) a hydrogen atom; or (b5) an (C2-C8) alkynyl group; q is an integer from 1 to 3, X can be the same or different and each is (c1) a hydrogen atom; (c2) a halogen atom; (c4) a cyano group; (c5) a nitro group; (c10) a CO group (R 4 ) where R 4 is as defined above; Petition 870180139221, of 10/09/2018, p. 11/17 8/10 (c14) an (C 1 -C 8) alkyl group; (c18) a halo (C1-C8) alkyl group; (c22) a tri (C1-C8) alkylsilyl group in which the alkyls can be the same or different; (c27) an (C1-C8) alkoxy group; (c31) a halo (C1-C8) alkoxy group; (c40) a halo (C1-C8) alkoxy-halo (C1-C8) alkoxy group; (c42) an (C1-C8) alkylthio group; (c46) a halo (C1-C8) alkylthio group; (c76) an aryl group; (c77) an aryl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group ( C1Ce) alkyl, (e) a halo (C1-Ce) alkyl group, (f) a (C1-Ce) alkoxy group, (g) a halo (C1-Ce) alkoxy group, (h) a (C2-) group C6) alkenyloxy, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a (C3- C6) cycloalkoxy, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1-Ce) alkoxy group, (o) a halo (C3-C6) cycloalkyl (C1-) group C6) alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1-C6) alkylthio group, (r) a (C1-C6) alkylsulfinyl group, (s) a halo group ( C1-C6) alkylsulfinyl, (t) a (C1C6) alkylsulfonyl group, (u) a halo (C1-C6) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined below, (w) an N group (R 4 ) COR 5 where R 4 and R 5 are as defined below, (x) an N group (R 4 ) CO2R 5 where R 4 and R 5 are as defined below, (y) an N group (R 4 ) SO2R 5 where R 4 and R 5 are as defined below, (z) a COR 4 group where R 4 is as defined below, (aa) a CO2R 4 group in which R 4 is as defined below, (bb) a CON (R 4 ) R 5 group in which R 4 and R 5 are as defined below and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined below; Petition 870180139221, of 10/09/2018, p. 12/17 [9] 9/10 (c80) an aryloxy group; or (c81) an aryloxy group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a nitro group, (d) a group (C1C6) alkyl, (e) a halo (C1-C6) alkyl group, (f) a (C1-C6) alkoxy group, (g) a halo (C1-C6) alkoxy group, (h) a (C2 -C6) alkenyloxy, (i) a halo (C2-C6) alkenyloxy group, (j) a (C2-C6) alkynyloxy group, (k) a halo (C2-C6) alkynyloxy group, (l) a (C3 -C6) cycloalkoxy, (m) a halo (C3-C6) cycloalkoxy group, (n) a (C3-C6) cycloalkyl (C1C6) alkoxy group, (o) a halo (C3-C6) cycloalkyl (C1-C6) group ) alkoxy, (p) a (C1-C6) alkylthio group, (q) a halo (C1-C6) alkylthio group, (r) a (C1-C6) alkylsulfinyl group, (s) a halo (C1) group -C6) alkylsulfinyl, (t) a (C1-C6) alkylsulfonyl group, (u) a halo (C1-C6) alkylsulfonyl group, (v) an N (R 4 ) R 5 group where R 4 and R 5 are as defined below, (w) a group N (R 4 ) COR 5 where R 4 and R 5 are as defined below, (x) a group N ( R 4 ) CO2R 5 where R 4 and R 5 are as defined below, (y) an N (R 4 ) SO2R 5 group where R 4 and R 5 are as defined below, (z) a COR 4 group where R 4 is as defined below, (aa) a CO2R 4 group in which R 4 is as defined below, (bb) a CON group (R 4 ) R 5 in which R 4 and R 5 are as defined below and (cc) a group C (R 4 ) = NOR 5 where R 4 and R 5 are as defined below; R 4 and R 5 can be the same or different and each is (i) a hydrogen atom, (ii) a (C1-C6) alkyl group, (iii) a (C3-C6) cycloalkyl group, (iv) an (C2-C6) alkenyl group, (v) an (C2C6) alkynyl group, (vi) a (C3-C6) cycloalkyl (C1-C6) alkyl group, (vii) a halo (C1-C6) alkyl group, (viii) a halo (C3-C6) cycloalkyl group, (ix) a halo (C2-C6) alkenyl group, (x) a halo (C2-C6) alkynyl group, (xi) a halo group (C3-C6) cycloalkyl (C1-C6) alkyl, (xii) a (C1-C6) alkylsulfonyl group, (xiii) a (C1-C6) alkylcarbonyl group, (xiv) a halo group (C1 Petition 870180139221, of 10/09/2018, p. 13/17 [10] 10/10 Ce) alkylcarbonyl, (xv) a (C1-Cejalcoxycarbonyl group, (xvi) a (C3-C6) cycloalkylcarbonyl group, (xvii) a phenyl group, (xviii) a phenyl group having the same or different 1 on the ring to 5 substituents selected from (a) a halogen atom, (b) a (C1Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, (d) an (C1-Ce) alkoxy group, (and ) a halo group (C1-Ce) alkoxy and (f) a phenoxy group, (xix) a phenoxyphenyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b ) a (C1-Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, (d) an (C1Ce) alkoxy group and (e) a halo (C1-Ce) alkoxy group, (xx) a hydroxy (C1C8) alkyl group, (xxi) a phenyl (C1-Ce) alkyl group, (xxii) a phenyl (C1Ce) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) one halogen atom, (b) a (C1-Ce) alkyl group, (c) a halo (C1-Ce) alkyl group, (d) a (C1Ce) alkoxy group, (e) a halo group (C1-C e) alkoxy and (f) a phenoxy group or (xxiii) a phenoxyphenyl (C1-C6) alkyl group having, on the ring, the same or different 1 to 5 substituents selected from (a) a halogen atom, (b) a (C1-Ce) alkyl group, (c) a halo (C1Ce) alkyl group, (d) an (C1-Ce) alkoxy group and (e) a halo (C1-Ce) alkoxy group; Y is CH or a nitrogen atom, m is an integer from 0 to 4 and Hal is a halogen atom, or a salt thereof.
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法律状态:
2017-12-12| B07D| Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]|Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. | 2018-03-27| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]| 2018-05-02| B07G| Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]| 2018-08-21| B06T| Formal requirements before examination [chapter 6.20 patent gazette]| 2019-02-26| B09A| Decision: intention to grant [chapter 9.1 patent gazette]| 2019-04-02| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/02/2013, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/02/2013, OBSERVADAS AS CONDICOES LEGAIS | 2021-11-23| B21F| Lapse acc. art. 78, item iv - on non-payment of the annual fees in time|Free format text: REFERENTE A 9A ANUIDADE. |
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申请号 | 申请日 | 专利标题 JP2012019768|2012-02-01| JP2012-019768|2012-02-01| JP2012171532|2012-08-01| JP2012-171532|2012-08-01| PCT/JP2013/052421|WO2013115391A1|2012-02-01|2013-02-01|Arylalkyloxy pyrimidine derivative, pesticide for agricultural and horticultural use containing arylalkyloxy pyrimidine derivative as active ingredient, and use of same| 相关专利
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