巴西专利BR112014005382B1 AUTOMATIC DRUG INJECTION DEVICE

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专利摘要:
device for automatic injection of drug doses. a device for automatic injection of doses of a drug compound comprising a sliding sheath (30) which, when pressed with its front end (3) against the injection site, interacts with the cam device (26, 27, 28) to activate the actuation of a plunger (8), controlling the distribution of a dose of drug. the piston guide device (44) is provided to control the drive sequence and devices (4) to arm the device in the dose distribution condition. new automatic needle protection and reconfiguration of a locked condition after each dose is delivered is provided. the number of components of the device is reduced resulting in a simpler structure and a cost reduction.
公开号:BR112014005382B1
申请号:R112014005382-0
申请日:2012-09-06
公开日:2020-09-24
发明作者:Mark Jeffrey Edhouse；Philip Jerome Driver；Guy Conwyn Julian Moseley；Scott Alexander Lewis
申请人:Menarini International Operations Luxembourg S.A.；
IPC主号:

专利说明:

[0001] [001] The present invention generally relates to devices for injection of medications and more precisely it relates to a device for automatic injection of medications especially a medication for allergic emergencies, such as epinephrine or adrenaline, according to a requested time sequence . In particular, the invention relates to a device for the automatic injection of two doses of a drug at two successive times. Fundamentals of the Invention
[0002] [002] Many devices of the type mentioned above allowing a patient to administer one or more (usually two) doses of a drug to himself are known. US 6575939 describes an autoinjector device comprising a syringe housed in a wrapper formed by an inner and an outer part capable of sliding with respect to each other. By pressing the end of the inner part (the outlet end of the needle) against the patient's skin at the injection site, the outer part slides forward along the inner part, thus unlocking a push button. By pressing the button, the syringe and the relevant plunger are activated to first propel the needle and then distribute the medication. The retraction of the needle in the wrap is achieved by interrupting the pressure at the end of the outer part against the skin. This autoinjector allows a single dose of medication to be administered.
[0003] [003] An autoinjector device for automatic administration of a single dose of a drug is also known from US 4031893. The autoinjector is equipped with an unlocking device with a deformable element for the triggering device. The syringe plunger is axially connected to a rod comprising four flexible axial arms having a toothed end engaged on the edge of an opening formed in a cap located at the end of the syringe housing. Sliding the cover causes the arm ends to deform and your teeth to release from the opening edge. In this way, the drive device is activated. The autoinjector according to this document also comprises a safety device to prevent accidental deformation of the arm ends and to activate the actuation device, consisting of a central extension insert from the cover and capable of entering between the stem arms to prevent them from bending.
[0004] [004] EP 700307 describes an autoinjector allowing the automatic delivery of a first dose of a drug and the manual administration of a second dose. The autoinjector device according to this patent provides for the use of a syringe housed in a sliding form in a tubular housing in two parts that can be separated to allow the positioning of the syringe containing two doses of medicine to be distributed and the removal after use. The slide of the syringe into the housing to penetrate the needle and inject the medication is operated by a mobile actuator between an armed position and an extended position. A releasable locking device is provided to limit the slide of the syringe plunger to a point corresponding to the volume of the first dose. The syringe is movably mounted in the tubular housing to allow the locking device to be removed after the first dose is dispensed and the plunger trigger device to be cocked again, if the second dose is administered automatically, or the syringe is removed if the second dose is administered manually. In addition, the drive device is provided with a safety lock formed by an element engaging a deformable pin of the drive device to keep it in a deformed condition, thus preventing it from being activated. Such an autoinjector is commercially available under the trademark Twinject® and allows the first dose to be administered automatically, but the second dose must be administered manually.
[0005] [005] The autoinjector according to EP 651662 is designed to perform a sequence of injections from a single syringe that is capable of making a limited sliding movement in a tubular housing. The syringe has a plunger to distribute doses of a medication through the needle and a spring-loaded device engages a plunger rod and, once they are armed, they retain the rod in a first position, while, when activated, they make the stem moves forward and this causes the syringe to slide and the needle to project and then a controlled slide of the plunger to deliver a dose of medicine. Manual arming devices are provided and the devices to re-activate the spring-loaded device.
[0006] [006] The plunger rod has a toothed profile in which a locking device engages and the syringe is housed in a bushing capable of limited movement in the tubular housing and provided with an additional lock which is also engaged with the profile toothed stem. When the device is armed by the manual arming device, both the drive device and the sleeve on which the syringe is located are moved towards the rear end of the tubular housing, the two latches engaging with the toothed profile of the stem. An axial groove connection between the bushing and the drive device allows for additional sliding between the integral lock with the drive device and the toothed profile to an extent equal to the profile slope. When the device is actuated, first the actuation device causes the syringe sleeve to slide up to a front stop and then the stem begins to slide with respect to the sleeve lock by an extension corresponding to the profile inclination, where the displacement of a volume of medicine is allowed along with its distribution through the needle.
[0007] [007] There is a strong need for an injector device for the automatic injection of a drug in two successive doses that is easy for the user and is easier to manufacture compared to conventional devices. The objective of the present invention is, therefore, to meet these requirements by providing an auto-injector drug device capable of allowing the patient to self-administer two successive doses of a drug in the easiest way possible, thus saving the patient from performing surgery operations. new complex / potentially dangerous frame / disassembly. Summary of the Invention
[0008] [008] The general purpose of the present invention is to provide a device for the automatic injection of multiple discrete nominal volumes of a drug compound, especially two doses of drug compound from the same syringe.
[0009] [009] A particular object of the present invention is to provide a device of the type mentioned above in which automatic injection of the discrete nominal volumes of the drug compound is achieved by combining rotational and translational movements of the device components.
[0010] [010] Another objective of the present invention is to provide a device of the type mentioned above in which the automatic injection of a prescribed dose is triggered by the use of a patient-activated linear slide of a component in combination with the angular displacement of the plunger device being driven by cam devices in an encapsulated chassis.
[0011] [011] It is an additional objective of the present invention to provide a device of the type mentioned above with an automatic sheath locking accessory for needle protection and prevention of inadvertent activation of the device before a dose is selected by the user.
[0012] [012] Another additional objective of the present invention is to provide a device of the type mentioned above capable of automatically protecting the needle and reconfiguring the locked condition after a dose is injected.
[0013] [013] Another objective of the invention is to provide a device of the type mentioned above in which the trigger function and the trigger function are integrated into the same support for lower tolerances, increasing reliability and reducing the number of device components, resulting in also in a simple device structure and reduced production cost.
[0014] [014] Another additional objective of the invention is to provide an autoinjector device of the type mentioned above in which production and assembly are easy to carry out.
[0015] [015] The above objectives are achieved with the device for automatic injection of doses of a drug according to the present invention, the main features of which are shown in the attached claim 1. Additional important features are shown in the dependent claims.
[0016] [016] In accordance with an important aspect of the device for automatic injection of doses of a drug compound according to the present invention, the axial movement of a sliding sheath, caused by the user by pressing its front end against the injection site , causes an angular displacement of the cam drive device, which, in cooperation with the stepped guide device, controls the movement of the plunger device of a syringe group and thus the distribution of preset doses of a drug compound. The movement of the plunger device is produced by the axial operation of the first elastic device, while the axial movement of the sliding sheath is hampered by the second elastic device which reinstates the initial needle cover condition of the sheath when the pressure action ceases. To make the device ready for dispensing a dose, the arming device is provided which, when operated, unlocks the axial sliding of the sheath. The locking condition, in addition to the needle retraction in the sliding sheath, are automatically reinstated when the pressure ceases under the action of the second elastic device.
[0017] [017] According to another important aspect of the invention, the cam drive device is formed on the same support, axially articulated, as the cam drive device with which the sliding sheath interacts to control the activation of the piston device of the syringe group.
[0018] [018] In accordance with a further aspect of the invention, the device that allows the device to be maintained in a resting state is formed in the support of the cam trigger device and the cam drive device and is unlocked as a result of a rotation of a dose selection button hingedly mounted on the device body and temporarily connected to the holder. Brief Description of Drawings
[0019] [019] The above and other characteristics, in addition to the advantages of the autoinjector device according to the invention, will be apparent from the following description of a non-illustrative modality with reference to the attached drawings, in which: Figure 1 is a perspective assembly view of the autoinjector device according to the present invention; Figure 2 is a partially exploded perspective view of the device of Figure 1; Figure 3 is a fully exploded view of the device in Figure 1; Figure 4 is a longitudinal section of the device of Figure 1; Figure 5 is a longitudinal section of the device of Figure 1 taken along the lines VV of Figure 4; Figure 6 is a detailed view of the connection between the dose selection button and the plunger rod in the device of figure 1; Figure 7 is an exploded view of the detail in Figure 6; Figure 8 is an axial perspective view of the dose selection button; Figure 9 is a partial top perspective view of the stem of the piston; Figure 10 is a perspective view of the external body of the device of figure 1; Figure 11 is a longitudinal section of the external body of Figure 10; Figure 12 is a partial top perspective view of the outer body of figure 10; Figure 13 is an assembly view of the device syringe group of the invention; Figure 14 is a perspective view of the operational connection between the cam sleeve and the sliding sheath in the device of the invention; Figure 15 is an axial side view of the sliding sheath; Figure 16 shows a sectional view of the sliding sheath taken along lines XVI-XVI of figure 15; Figure 17 is a front perspective view of the sliding sheath of Figures 15 and 16; Figure 18 is an axial side view of the cam sleeve on the device of the invention; Figure 19 is a rear perspective view of the cam sleeve of the figure 18; Figure 20 is a front perspective view of the cam sleeve of the figure 18; Figure 21 illustrates the device armed for dispensing the first dose and ready for activation; Figures 22a, 22b and 22c are detailed views of the device of the invention in position 0 (stored position) and position 1 (first armed dose); Figures 23a and 23b illustrate the device of the invention at the beginning and at the end of the first dose delivery step; Figure 24 illustrates the device in the sheath replacement and reconfiguration step; Figures 25a and 25b illustrate the details of the second dose selection step; Figures 26a, 26b and 26c illustrate the distribution steps of the second dose; Figure 27 is a perspective assembly view of a second embodiment of the autoinjector device according to the present invention; Figure 28 is a partially exploded perspective view of the device of Figure 27; Figure 29 is a fully exploded view of the device of Figure 27; Figure 30 is a longitudinal section of the device of Figure 27; Fig. 31 is a longitudinal section of the device of Fig. 27 taken along lines XXXI-XXXI of Fig. 30; Figure 32 is a detailed view of the connection between the dose selection button and the plunger rod in the device of figure 27; Figure 33a is a detailed cross-sectional view of the connection between the piston rod and the ratchet; Figure 34 is a partial top perspective view of the piston; Figure 35 is an axial perspective view of the dose and ratchet selection button set; Figure 36 is an exploded perspective view of the chassis and outer sleeve assembly forming the outer body of the device of Figure 27; Figure 37 is a longitudinal section of the chassis and outer sleeve assembly of Figure 36 as mounted; Figure 38 is a partial top perspective view of the chassis of the figure 36; Figure 39 is an overall view of the syringe group of the device of figure 27; Figures 40a, b, and c are, respectively, side, perspective and longitudinal section views taken along lines 40c-40c of figure 40a of the sliding sheath in the device of figure 27; Figures 41a, b and c are, respectively, side, perspective and reverse perspective views of the cam sleeve in the device of figure 27; Fig. 42 is a perspective view of the operational connection between the cam sleeve and the sliding sheath in the device of Fig. 27; Figures 43a and 43b are detailed views of the device of figure 27 in position 0 (stored position) and in position 1 (first armed dose); Figure 43c is a cross-sectional view of the device in the first armed dose position of Figure 43b; Figures 44a and 44b illustrate the device just before and at the trigger point; Figure 45 illustrates the device after dispensing the first dose during the sheath replacement step; Figures 46a and 46b illustrate the device in the stored position after the delivery of the first dose and, respectively, in the position of the second armed dose and ready for delivery of the second dose; Figures 47a, b and c are partial broken side views showing the device of figure 27 in the second dose position of figure 46b, during movement towards the trigger point and, respectively, in the second dose trigger stage; Figures 48a, b and c are detailed side views of the bayonet connection of the device according to the second embodiment of the invention before, during and, respectively, in the uncoupling step.
[0020] [020] With reference to figures 1 to 5, the autoinjector device according to the present invention comprises an outer body 1 of tubular shape, in particular a cylindrical body, extending along an X axis and containing most of the device components. The outer body is formed by the two coaxially aligned body parts 1a, 1b having a different diameter separated by a step 1c, against which the end of a removable end cap 2 rests, said cap 2 hiding the front end 3 the device. In proximity to the other end, the rear end of the device, angularly spaced reference marks are formed or labeled, for example, the numbers 0, 1, 2 indicating a state of rest or storage (0), and two operational states (1 , 2) of the device, as will be explained later. In the present description, the terms "front", "back" and equivalences refer to the part of the device intended for the needle outlet and, respectively, the axially opposite part. It is also mentioned that in the present description reference is always made to a device for the automatic injection of two doses of a drug, but it should be understood that the invention also comprises devices capable of delivering more than two doses of a drug in successive moments, through changes and alteration of the device that will be obvious to a person skilled in the art.
[0021] [021] A dose selection button 4, on which a reference indicator 5 is formed, is provided at the rear end of the device. The dose selection button 4 is axially articulated with respect to the outer body 1 to allow the indicator 5 to align the reference marks 4 formed on it.
[0022] [022] A group of syringes, usually indicated by 6, is housed in the outer body 1. As illustrated in figure 13, the syringe group comprises a syringe pre-loaded with drug 7, with needle 7a, needle guard 7b, drum 7c and intero plunger stop 7d. The barrel 7c engages the end of a piston rod 8, formed by a tubular element in two parts 8a and 8b of different diameters. The part 8a has a cross section that is in a released condition with respect to the inner section of the drum 7c so that it can slide, and an end shaped to engage with the plunger stop 7d as a result of an axial movement to push the same forward in the distribution of the drug. The piston rod part 8b has a larger diameter and is formed with internal radial ribs 9 to align an energy spring 10 extending axially on the piston rod 8. The energy spring 10 is in a compressed state and rests against the closed end of part 8a of the piston rod 8 with one end and against the lower wall 4a of the dose selection button 4 with its other end. The energy spring 10 also winds around a support rod 11 extending from the same lower wall 4a of the dose selection button 4 to the closed end of part 8a of the piston rod 8. The arrangement of the energy spring 10 between the radial ribs 9 and the part 8a of the piston rod and the support rod 11 helps to minimize the volume of the energy spring 10.
[0023] [023] In the stored state of the device, the dose selection button 4 is connected to part 8b of the plunger rod 8 by a bayonet connection, illustrated in particular in Figures 5 to 9, comprising a pair of partitions substantially shaped L 12 formed circumferentially in part 8b in diametrically opposite positions and a pair of retaining clips 13 projecting internally from the dose selection button 4 in diametrically opposite positions. The substantially L-shaped partitions 12 comprise a retaining partition branch 12a, extending circumferentially, and a release partition branch 12b, extending axially to the edge of part 8b of the plunger rod 8 When indicator 5 on the button 4 is aligned with the reference mark 9, the two retaining fasteners 13 are engaged with the respective retaining partition branches 12a of the partitions 12, thereby preventing the piston rod 8 from sliding axially. As a result of an axial angular displacement of the plunger rod relative to the button 4, the retaining fasteners 13 slide on the retaining partition branches 12a until they come into alignment with the respective release partition branches 12b extending backward to the free end of part 8b of the plunger rod 8, thus allowing the plunger rod 8 to travel forward under the action of the energy spring 10, as will be explained later on the device operation.
[0024] [024] Two radial pins 15 project outwardly from part 8b of the piston rod in diametrically opposite parts. The two radial preachers 15, which slide into actuating cam devices, provide a means of guiding the movement of the plunger rod 8 which controls the drug dose distribution, as will be explained later.
[0025] [025] As shown in figures 4, 5 and 6, the dose selection button 4 is formed with a perimeter groove 16 in which a recess 17 at the rear end of the outer body 1 slidably engages, where the selection button of dose 4 is articulated in relation to the external body 1 so that the selection of the dose to be administered is allowed.
[0026] [026] The dose selection button 4 can rotate in only one direction and for this purpose, the connection between the button 4 and the external body 1 comprises a device to prevent rotation in the opposite direction to that of the dose selection. These devices comprise a pair of ratchet extensions 18 (see figures 6 and 7) extending perimetrically from the edge of button 4, suitable for sliding support, when button 4 is rotated, on an inclined indexing surface 19 defining two steps of inclination 19a, b (only one illustrated in figures 10 and 11). When the extensions 18 slide on the slope surface 19, they first flex and then, once the slope is overcome, trigger the slope step 19a, b present at the end of the slope, leaning against it and preventing reverse rotation. A stop rib 20 is also provided on the inclined surface, against which the ratchet extensions 18 rest to prevent any further rotation of the button after the button reaches the position corresponding to the second dose delivery.
[0027] [027] As illustrated in figures 6 to 8, a pair of diametrically opposed bases 21 extend axially from the free edge of the dose selection button 4 through part 8b of the piston rod 8 and engage respective seats 22 of a tubular-shaped support 23, referred to as cam sleeve 23 (figures 18 to 20) in the present description, formed at the rear end. The seats 22 have a front edge 22a against which bases 21 rest to put the cam sleeve 23 in full rotation with the dose selection button 4. A positioning flange 24 extends outwardly around the same end of the sleeve cam 23 designed to rest on a corresponding rim 25 within the outer body 1 near its rear end, thereby preventing mutual axial sliding.
[0028] [028] As illustrated in figures 18 to 20, the cam sleeve 23 is formed with two sections with different functions; a first section 23a towards the front end, called the front section, and a second section 23b towards the rear end, called the rear section. The front section 23a is operatively connected to a sliding sheath 30 (see figure 14), whose axial sliding causes the cam sleeve 23 to move in an angular manner, as will be explained later, while the rear section 23b is operatively connected to the rod plunger 8 through its radial pins 15 and, as already mentioned, to the dose selection button 4 (see especially figure 20).
[0029] [029] The cam sleeve 23 is pivotable on the outer body 1 and is maintained in axial alignment by the positioning flange 24.
[0030] [030] The rear section 23b of the cam sleeve 23 is provided with a drive cam device to control the movements of the piston rod 8. The drive cam device comprises two windows 26 diametrically opposite and symmetrical to the axial rotation with respect to the their shape, opened towards the rear edge of the cam sleeve through a respective axial extension channel 27 defining a first dose drive cam rail 27a. Each window is bounded by two parallel circumferential sides 26a, 26b, an axial side 26c connecting the two ends of the sides 26a, 26b, and an angled side 26d, opposite the axial side 26c, connecting the other end of the side 26b opposite the channel 27 to one side of channel 27. Channel 27 opens in window 26 on the inclined side 26d and the axial side 26c forms the second dose drive cam rail. The first dose drive cam rail 26c is spaced angularly from the second dose drive cam rail 27a.
[0031] [031] The drive cam device 28 is engraved on the outer surface of the front section 23a of the cam sleeve 23. The drive cam device 28 is formed by a cam profile repeated four times at an angle equidistant to said surface. The cam profile comprises a first drive cam rail 28a, extending from the end of the sleeve cam 23, called a rising rail for the sake of simplicity, and inclined with respect to the X axis, and a second cam rail of drive 28b, called descending rail for the sake of simplicity, extending from the same end of cam sleeve 23 and incident with the first driving cam rail 28a. On the rising track 28a, and successively on the falling track 28b, a pair of drive pins 32 is designed to slide. The drive pins 32 protrude inwardly from two diametrically opposed axial drive pins 31 from the sliding sheath 30 (figures 15 to 17). When a pressure action is exerted on the free end 3 of the sliding sheath 30, the cam sleeve 23 is rotated in the opposite direction to the inclination direction of the upward rail 28a, and, respectively, when the pressure action is terminated.
[0032] [032] On the descending rail 28b of the drive cam device 28, relevant cantilever extensions 29 are formed to be internally deformed to allow the drive pins 32 to pass. In the stored state of the device, the drive pins 32 rest on each other an axial locking edge 29a (figures 4 and 14) at the free end of the cantilever extensions 29, thereby preventing the sliding sheath 30 from moving towards the rear end of the device. A stop edge 28c, located laterally with respect to the axial locking edge 29a, serves as support for the drive pins 32 to prevent the dose selection knob 4 from rotating beyond the first dose and second dose delivery positions, as will be explained later.
[0033] [033] The end of the sliding sheath 30 on the side opposite the drive extensions 31 constitutes the front end 3 of the device, that is, the end intended to be placed in contact with the patient's skin at the injection site. The needle 7a of the syringe 7 will project from said front end 3 through a central opening 33 therein. A central spring protrusion 34 for the slide housing of the syringe 7 extends from the inner face of the front end 3 of the sliding sheath 30. A return spring 35 is wound around the central spring protrusion 34 and rests against the face front end 3 with one end and against a surface of the outer body 1 with its other end.
[0034] [034] The drive extensions 31 are slidably engaged with axial guides 36 formed on the outer body 1, where the sliding sheath 30 can only move axially on the outer body 1. Two wide axial openings 37, arranged at 90 with respect to the drive extensions 31, are formed in the sliding sheath 30. The axial openings 37 are axially aligned with the corresponding transparent inspection windows 38 formed in the outer body 1, through which the barrel 7c of the syringe 7 is visible, where the user can control the condition of drug distribution. The support surface for the return spring 35 on the outer body 1 consists of the lower wall 38a of said inspection windows 38. The axial openings 37 allow the sliding sheath 30 to travel axially for the necessary distance while not touching the windows on the body external 1.
[0035] [035] A pair of mounting fasteners 39 extends from the bottom of, and within the axial openings 37 of the sliding sheath 30 to engage by pressure with the corresponding end stops 40 formed at the front end of the outer body 1, so to allow the assembly of the sliding sheath 30 inside the outer body 1 and prevent its release.
[0036] [036] The front edge of the outer body 1 rests on respective front edges 41a of a pair of flexible tips 41 formed in the sliding sheath 30 on diametrically opposite sides. The leading edge 41a of these tubs is angled to provide resistance to the movement of the sliding sheath 30 and to make this movement possible only as a result of a moderate thrust that deforms the tips 41 inward until the edge of the outer body 1 overcomes the far end projected from the tips 41. The movement subsequently created by releasing the tips 41 helps to quickly insert the needle 7a from the syringe 7 into the injection site.
[0037] [037] A tubular housing 2 for the syringe 7 is formed in the outer body 1 and a flange 42a is formed at one end thereof, where a corresponding flange 7e of the barrel 7c rests. The two flanges are locked together by retaining clips 43 projecting internally from the outer body 1 (see figures 5, 11 and 13).
[0038] [038] As illustrated in figure 11, the guide device 44 is engraved on the internal surface of the external body 1 to control the axial movement of the piston rod 8 and thereby limit the volume of drug delivered. These guiding devices are in the form of a stepped rail with a first locating face 44a, a second locating face 44b and a stop projection 44c, meeting in the planes perpendicular to the X axis. The edge of the first locating face 44a is connected to the second locating face 44b by a first axial side 44d, and the edge of the second locating face 44b is connected to the stop protrusion 44c by a second axial side 44e. A pair of diametrically opposed staggered rails, symmetrical to the axial rotation with respect to their shape, are formed in the outer body 1. The radial pins 15 of the piston rod 8 are designed to slide along the first and second locating faces 44a and 44b as a result of the rotation of the cam sleeve 23 and fall from the first location face 44a to the second location face 44b and from the last to the stop protrusion 44c in the distribution of the first and second doses of drug, while moving along the first side axial 44d and, respectively, the second axial side 44e, as will be explained later.
[0039] [039] A needle guard remover 45 (figures 2 to 5) is removably attached to the outer body 1 by snap-on retention extensions 45a and is provided with an internal tubular grip 45b fitted to engage with the needle guard 7b, such that, by retracting the needle guard remover 45 before the first dose is administered, the user can remove the needle guard 7b and release the needle 7a for injection.
[0040] [040] The following is a description of the way in which the autoinjector device according to the invention is used.
[0041] [041] In the initial state, the stored state, the spring energy spring 10 is compressed between the closed end of part 8a of the plunger rod 8 and the lower wall 4a of the dose selection button 4. The bayonet connection between the button 4 and the plunger rod 8 ensure that the energy spring 10 remains compressed until the first dose is selected. Any volume of the energy spring 10 is prevented by being arranged between the radial ribs 9 and the part 8a of the piston rod 8 on one side and the support rod 11 on the other. Needle guard 7b is attached to syringe 7 and needle guard remover 45 is attached to needle guard 7b. The cover 2 is attached to the outer body 1 and the sliding sheath 30 is prevented from moving axially since the drive pins 32 of the drive extensions 31 rest against the respective locking edges 29a of the cam sleeve 23.
[0042] [042] The dose selection button 4 is connected to the outer body 1 through its outer perimeter groove 16, with which it slidably engages the recess 17 at the rear end of the outer body 1. Once assembled, the selection button dose 4 cannot move axially, but can only rotate in one direction. The direction of rotation is indicated by the reference marks on the outer body: in other words, indicator 5 starts at position 0, rotates to position 1 when the first dose is selected, and then rotates to position 2 when the second dose is selected.
[0043] [043] In the stored state the device is "locked", that is, the sliding sheath 30 cannot move on the outer body 1, since the driving extensions 31 of the sliding sheath 30 rest against the axial locking edges 29a of the sleeve cam 23. This condition is illustrated in particular in figure 14. When selecting the first dose (position 1), the device is unlocked as shown in figure 21. In fact, by rotating the dose selection button 4, the cam 23 is pushed in the same direction by the bases 21 of the button 4 which rest on the front edge 22a of the seats 22 of the cam sleeve 23. The dose selection button 4 cannot rotate beyond position 1 until the first dose is delivered , since the driving pins 32 of the extensions 31 rest on the circumferential stopping edge 28d of the cam rail 28 on the cam sleeve 23. The sliding sheath 30 is prevented from rotating since the extensions 31 can only move axially forward and to back on axial guides 36 n the outer body 1.
[0044] [044] First, the user must slide back and remove end cap 2a in order to expose needle guard remover 45. End cap 2 will have to be replaced once the first dose is delivered when the device is not is in use. End cap 2 protects the drug against light exposure and prevents particles from coming into contact with the front end 3 of the device.
[0045] [045] To perform the first injection, the user must remove the needle guard remover 45. This way, the needle guard 7b is also removed leaving the needle 7a uncovered, but still below the leveling of the front end 3 and not readily visible for the user. To unlock the device and select the distribution of the first dose, the user turns the dose selection button 4 from position 0 (stored status) to position 1 (first armed dose).
[0046] [046] Rotating the dose selection button 4 from position 0 to position 1 causes the cam sleeve 23 to rotate, where the axial locking edges 29a of the cantilever extensions 29 travel relative to the drive pins 32 of the extensions 31 of the sliding sheath 30, which rest against the circumferential stop edge 28d to prevent the button 4 from turning further until the first dose is dispensed and are aligned on the rising parts 28a of the cam rail 28 free to move along them. The user recognizes the end of the rotation to position 1 when he sees that the indicator 5 is aligned with the position marker 1, feels the increase in the rotation resistance of the drive pins 32 in contact with the cam rail 28 and also hears a "click" as produced by the ratchet extensions 18 falling from step 19a of the sloping surface 19. The contrast between extensions 18 and steps 19a prevents knob 4 from turning in the reverse direction.
[0047] [047] The device is triggered by the user by pressing the front end 3 of the sliding sheath 30 against the injection site keeping the device through the outer body 1. The movement of the sliding sheath 30 in the outer body 1 encounters a resistance due to the contrast between tips flexible ends 41 and the outer body end 1. Due to their flexibility and the inclined contact surface, the flexible tips 41 fully press and deform to allow the slide sheath 30 to slide through the outer body 1 leaving the needle 7a to project from its front end 3, so that the needle can penetrate the injection site. The movement subsequently created by releasing the flexible tips 41 helps to quickly insert the needle 7a into the injection site.
[0048] [048] The axial movement of the sliding sheath 30 in the outer body 1 causes the cam sleeve 23 to rotate and the last one enters by rotating friction also with the dose selection button 4. To prevent the button 4 from turning during the step of the distribution of the first dose, between the dose selection button 4 and the temporary stop device of the external body 1 are provided and engage each other when the free ends of the ratchet extensions 18 fall from the step 19a of the inclined surface 19 of the external body 1. In the present embodiment, the temporary stop device comprises retaining pips 46 of the external body engaging with the corresponding locks 47 of the button 4 as illustrated in figures 6, 11 and 22c. The rotation force acting on the dose selection button 4 upon activation is less than the holding force provided by the pips 46. However, the rotation force that the user can provide is much greater than that of the pips. Therefore, the user can overcome the force of the pip and turn the knob 4 to arm the device for the second dose.
[0049] [049] The rotation of the cam sleeve 23 causes the plunger rod 8 to rotate due to the engagement of its radial pins 15 in the corresponding axial channels 27. After a few degrees of rotation the bayonet connection between the dose selection button 4 and the piston rod 8 disengages due to the retaining fasteners 13 of the button 4 reaching the relevant axial release partition branches 12b of the piston rod 8 and, under the action of the energy spring 10, the piston rod 8 is pushed forward to place the radial pins 15 supported on the first locating face 44a of the step guide 44 of the outer body 1.
[0050] [050] While the cam sleeve 23 continues to rotate, the radial pins, pushed by the first dose drive cam rail 27a, slide on the first location face 44a until they reach the end and fall off the second location face 44b of the step guide 44 under the action of the energy spring 10. This sequence is illustrated in figures 23a and 23b. The axial slip resulting from the plunger rod 8 causes the distribution of the first dose.
[0051] [051] After dispensing the first dose, the user removes the device from the injection site and needle 7a is removed. The return spring 35 is no longer affected by the forced contact between the front end 3 and the injection site and, thus, pushes the sliding sheath 30 axially forward, thus protecting the needle again. At the same time, the drive pins 32 of the drive extensions 31 slide down into the downward position 28b of the cam rail 28 by pressing in on the cantilever pins 29 until the device returns to a "locked" condition, where the drive 32 come into contact with the free end 29a of the cantilever extensions 29 and the mounting clips 39 of the sliding sheath 30 again engage with the end stops 40 of the outer body 1, as shown in figure 24. The needle 7a is again not accessible as being covered by the sliding sheath 30, which, in this state, is prevented from sliding until the user turns the dose selection knob 4 to position 2. The user then covers the device again. The end cap 2 snaps into place with the outer body 1 to hold the device securely.
[0052] [052] If the delivery of a second dose is necessary, the user unlocks the device to allow access to the sliding sheath 30. To unlock the device, the user can turn the dose selection knob 4 from position 1 (first position armed dose) to the second position 2 (second armed dose position).
[0053] [053] For this purpose, the user must overcome the reaction of the beams 47 of the button 4 in the retaining pips 46 of the external body 1. The bases 21 of the button 4 occupy the free path in the seat 22 of the cam sleeve 23 until they reach the leading edge 22a for rotating the cam sleeve 23 to position 2, as shown in figures 25a and 25b. At the same time, the rotation of the cam sleeve 30 causes the device to unlock as the driving pins 32 of the driving extensions 31 of the slide sheath 30 align the rising part 28a of the cam rail 28 while contacting the circumferential stop edge 28d to prevent further rotation of button 4 once position 2 is reached. The reverse rotation of the dose selection button 4 is prevented by the toothed extensions 18 supported by pressure on the step 19a of the inclined surface 19. The rotation of the cam sleeve 23 also causes the repositioning of the radial pins 15 from the axial channel exit 27 inside the window 26 to the opposite axial side 26c, while its position on the second location face 44b of the step guide 44 is not changed.
[0054] [054] The device is activated to distribute the second dose by the user by pressing the front end 3 of the sliding sheath 30 against the injection site by maintaining the device through the outer body 1. The movement of the sliding sheath 30 in the outer body 1 meets resistance due to the contrast between the flexible tips 41 and the end of the outer body 1. Due to their flexibility and the inclined contact surface, the flexible tips 41 press and deform completely inwards to allow the passage of the sliding sheath 30 that can slide in the outer body 1 leaving the needle 7a to project from its front end 3, so that the needle can penetrate the injection site. The movement subsequently created by the release of flexible tips 41 helps to quickly insert the needle 7a at the injection site.
[0055] [055] To prevent any further rotation of knob 4, once position 2 is reached, at the end of the next rotation of the cam sleeve 23 the base of the toothed extensions 18 contacts the stop rib 20 of the indexing inclination 19, for example whereby the toothed extensions 18 are retained between the step 19a and said stop rib 20.
[0056] [056] While the cam sleeve 23 is kept rotating, the radial pins 15 slide on the second location face 44b of the step guide 44 as pushed by the axial side 26c of the window 26 until they reach the end of said face, from where they fall of the stop protrusion 44c of the step guide 44 due to the action of the energy spring 10. This operational sequence is illustrated in figures 26a and 26b. The axial slip resulting from the plunger rod 8 causes the distribution of the second dose.
[0057] [057] It is worth noting that a small volume of drug always remains in the syringe plunger. In fact, the position of the stop protrusion 44c of the step guide 44 is designed so that when the radial pins 15 reach the stop protrusion 44c, the plunger stop 7d does not touch the bottom of the drum 7c. In this way, not only the distribution of the prescribed volume of the drug can be controlled, but also any manufacturing variation with respect to the internal length of the syringe barrel is guaranteed to be mitigated. Therefore, dose accuracy is improved.
[0058] [058] After dispensing the second dose, the user removes the device from the injection site and needle 7a is collected. The return spring 35 is no longer affected by the forced contact between the front end 3 and the injection site and, thus, pushes the sliding sheath 30 axially forward, thus protecting the needle again. At the same time, the drive pins 32 of the drive extensions 31 slide downward on the descending rail 28b of the drive cam device 28 and press inward on the cantilever extensions 29 until the device returns to a "locked" condition, where the drive pins 32 contact the free end 29a of the cantilever extensions 29 and the mounting clips 39 of the sliding sheath 30 again engage with the end stops 40 of the outer body 1, as at the dispensing end of the first dose. The needle 7a is again not accessible as being covered by the sliding sheath 30. The user then covers the device again with its end cap 2 before disposal or handling by the paramedic.
[0059] [059] Even if the autoinjector device according to the invention described above is equipped with two radial pins 15 to guide the movements of the piston rod 8, this solution being the preferred one because it has a symmetrical distribution of the forces acting on the various components, it is It is clear that the solution in which only a radial preacher 15 is provided is understood within the scope of the invention to be an obvious variation thereof. In that case, the stepped guide device 44, the trigger cam device 26, 27 and the drive cam device 28 will be modified accordingly.
[0060] [060] Figures 27 to 48 illustrate a second embodiment of the autoinjector device according to the invention characterized by a different configuration of some components, while maintaining substantially the same operation with respect to the autoinjector device described above.
[0061] [061] With reference to figures 27 to 31, in the autoinjector device according to the second embodiment of the present invention, the external body, generally indicated by 100, is formed by two distinct components 100a and 100b, called chassis and external sleeve respectively, that can be attached to each other coaxially. In particular, a part of the chassis 100a engages with the sleeve 100b and is secured by teeth 101 to snapped into the corresponding grooves 101b of the sleeve 100b (see figure 36). The outer diameter of the sleeve 100b is greater than that of the chassis 100a, thus forming a step 101c, against which the end of a removable end cap 102 rests, said cap 102 hiding the front end 103 of the device. The removable end cap 102 is removably attached to the chassis 100a by the cap retaining teeth 101d snapped into the corresponding grooves 102a formed in the end cap 102. A pen clip 100c extends along the side wall of the sleeve 100b to hang the auto-injector device, for example, from a pocket.
[0062] [062] In proximity to the other end, the rear end, of the outer body 100, angularly spaced reference marks are formed or labeled, for example, the numbers 0, 1, 2, indicating a resting or stored state (0) , and two operational states (1, 2) of the device, as will be explained later.
[0063] [063] A dose selection button 104, of which a reference indicator 105 extends axially, is provided at the rear end of the eternal body 100. The dose selection button 104 is axially articulated with respect to the outer body 100 to allow that indicator 105 aligns with the reference marks formed on it.
[0064] [064] In the present embodiment of the invention, a substantially cup-shaped ratchet 204 is housed under dose selection button 104. Ratchet 204 is created integrally with button 104 through a pair of flaps 205 extending internally on the button in diametrically opposite parts and formed with cuts 206 for the press fit with the lateral axial retention ribs 204c of the ratchet 204 (see figures 32 and 33).
[0065] [065] A group of syringes, usually indicated by 106, is housed in the outer body 100. As illustrated in figure 39, the syringe group comprises a syringe pre-loaded with drug 107, with needle 107a, needle guard 107b (see also figure 29), drum 107c and internal piston stop 107d. The barrel 107c engages the end of a piston rod 108, formed by a tubular element in two parts, the front part 108a and the rear part 108b of different external diameter. The front part 108a has a cross section that is in a released condition with respect to the inner section of the drum 107c so that it can slide, and an end configured to engage with the plunger stop 107d as a result of an axial movement to push forward in drug distribution. The rear part 108b of the piston rod 108 has a larger diametrical size.
[0066] [066] The internal diameter of the plunger rod 108 is dimensioned to accommodate an energy spring 110 axially extending along its entire length. As shown in figures 30 and 31, the energy spring 110 is in a compressed state and rests against the closed end of the front part 108a of the plunger rod 108 with one end and against a lower wall 204a of the ratchet 204 with its other end . The power spring 110 also winds around a support rod 111 extending from a retaining hole 204b formed centrally in the lower wall 204a of the ratchet 204 to the closed end of the front part 108a of the piston rod 108. The arrangement of the energy spring 110 between the support rod 111 and the inner front wall 108a of the piston rod helps to minimize the volume of the energy spring 110.
[0067] [067] From the lower wall of the dose selection button 104, a pair of diametrically opposed protrusions 109 (figure 35) extends inwards configured to engage with the corresponding cutouts 207 formed at the bottom of the ratchet 204, where a rotation torque exerted by the user on the dose selection button 104 is transferred to the ratchet 204 through the projections 109 and the cutouts 207 and from the ratchet 204 to the components of the connected autoinjector device, as will be explained below.
[0068] [068] The piston rod 108 and the ratchet 204 are coupled by a bayonet connection that keeps the energy spring in a compressed state until the device is activated. With reference to figures 33 to 35, the bayonet connection comprises a pair of retaining bases 112 projected inwardly from the ratchet 204 in diametrically opposite parts and corresponding drive partitions 113 extending from the piston rod 108 and hanging from the retention bases 112. Retention stability is guaranteed by the axial force provided by the compressed energy spring 110, but the connection need not have any circumferential restrictions other than those resulting from the mutual friction between the bases 112 and the partitions 113.
[0069] [069] Two radial nails 115 project outwardly from the rear 108b of the piston rod 108 in diametrically opposite parts. The two radial preachers 115, illustrated in particular in figures 32 to 34, provide a means of guiding the movement of the piston rod 108, which controls the drug dose distribution, by sliding in the actuation cam device, as will be explained later .
[0070] [070] The connection between the outer sleeve 100b and the ratchet and button assembly is created (see figures 30 and 31) through an inward facing flange 150 of the sleeve 100b leaning on a mobile ring 151 of the ratchet 204, while the free edge of button 104 rests on the rear edge of outer sleeve 100b. In this way, the sleeve 100b is held captive between the selection button 104 and the ratchet 204 during the pressure fitting process. Centering ribs 152 extend from the movable rim 151 on the ratchet 204 to provide axial alignment between the ratchet 204 and the sleeve 100b.
[0071] [071] The dose selection knob 104 can rotate in only one direction with respect to sleeve 100b and for that purpose the connection between ratchet 204 and sleeve 100b comprises means to prevent rotation in the opposite direction to that of dose selection after that the button reaches one of the operational positions. These means comprise a pair of flexible ratchet extensions 118 (see figures 35 and 36) extending perimetrically from the edge of the ratchet 204, suitable for sliding support, when the knob 104 is rotated, in the respective anti-return rotation ribs 119, visible in figure 43c, of sleeve 100b. When extensions 118 slide, they first flex due to the presence of ribs 119 and then, once the ribs take over, they activate the support against them and prevent the reverse rotation of button 104. A stop rib 120 (visible in the figure 43c) is also provided along the face of the sleeve 100b where the ratchet 204 slides. A corresponding protrusion 120a of the ratchet 204 rests against the stop rib 120 to prevent any advance rotation of the button after the button reaches the position corresponding to the dose distribution. However, the protuberance 120a must be deformed, as a result of moderate force, to overcome the stop rib 120 and allow passage from one operational position to another.
[0072] [072] As illustrated in figures 33 and 41a, b, c, a pair of diametrically opposed bases 121 extends axially from the ratchet 204 through part 108b of the piston rod 108 and engages in respective grooves 122 of a support 123 of tubular shape, referred to as cam sleeve 123 in the present description, formed at the rear end. The grooves 122 have a leading edge 122a against which a rotating extension 121a of the bases 121 rests to bring the cam sleeve 123 into full rotation with the dose selection button 104 through the ratchet 204. A positioning flange 124 (see also figures 30 and 31) extends outwardly around the same end of cam sleeve 123 designed to support with one face on a corresponding rim 125 within outer sleeve 100b near its rear end, and with the other face on the rear edge of the chassis 100a, thus preventing mutual axial sliding.
[0073] [073] As illustrated in figures 41a, 41b and 41c, the cam sleeve 123 is formed with two sections with different functions: a first section 123a towards the front end of the device, called the front section and a second section 123b towards the rear end, called the rear section. The front section 123a is operatively connected to a sliding sheath 130 (see figure 30), whose axial sliding causes the cam sleeve 123 to move angularly, as will be explained later, while the rear section 123b is operatively connected to the radial nails 115 of plunger rod 108 and, as already mentioned, to the dose selection button 104 (see especially figure 42) through the ratchet 204.
[0074] [074] The cam sleeve 123 is pivotable on the outer sleeve 100b and is maintained in axial alignment by the positioning flange 124. The stop of rotation is created by a pair of lateral ribs 124a on the outer edge of the flange 124 resting on supports corresponding, not illustrated, formed in sleeve 100b.
[0075] [075] The rear section 123b of the cam sleeve 123 is provided with trigger cam devices to control the movements of the piston rod 108. The trigger cam device comprises two windows 126 diametrically opposite and symmetrical to axial rotation with respect to their shape, opened towards the rear edge of the cam sleeve through a respective axial extension channel 127 defining a first dose trigger cam rail 127a. Each window 126 is bounded by two parallel circumferential sides 126a and 126b, an axial side 126c connecting two ends of sides 126a, 126b, and an angled side 126d, opposite the axial side 126c, connecting the other end of side 126b, opposite to channel 127, on one side of channel 127. Channel 127 opens in window 126 on the inclined side 126d and the axial side 126c forms the second dose trigger cam rail. The first dose trigger cam rail 127a is spaced angularly from the second dose trigger cam rail 126c. In the present embodiment, side 126b is located at the end of an enlarged space in windows 126 to compensate for the voids and tolerances associated with manufacturing variation of component characteristics.
[0076] [076] The drive cam device 128 is engraved on the outer surface of the front section 123a of the cam sleeve 123. The drive cam device 128 is formed by a cam profile repeated four times angularly equidistant on said surface. The cam profile comprises a first drive cam rail 128a, extending from the end of the cam sleeve 123, called a rising rail for the sake of simplicity, and inclined with respect to the X axis, and a second cam rail of drive 128b, called downward rail for simplicity, extending from the same end of cam sleeve 123 and incident with the first drive cam rail 128a. On the rising track 128a and successively on the falling track 128b a pair of drive pins 132 is designed for sliding drive. The drive pins 132 project inwardly from two diametrically opposed axial drive extensions 131 of the sliding sheath 130 (figures 40a, 40b, and 40c). Sliding occurs when a pressure action is exerted on the free end 103 of the sliding sheath 130, where the cam sleeve 123 is rotated in the direction opposite to the inclination direction of the rising rail 128a, and, respectively, when the pressure action stops.
[0077] [077] On the downward track 128b of the drive cam device 128 relevant cantilevered extensions 129 are formed to be deformed internally to allow the drive pins 132 to pass through during the downward drive pin return step. In the stored state of the device, the drive pins 132 rest on an axial locked edge 127a at the free end of the cantilever extensions 129, thereby preventing the sliding sheath 130 from moving towards the rear end of the device. A stop edge 128c, located laterally with respect to the axial locking edge 129a, serves as support for the drive pins 132 to prevent the ratchet 204 from rotating beyond the first and second dose delivery positions, as will be explained later.
[0078] [078] The end of the sliding sheath 130 on the side opposite the drive extensions 131 constitutes the front end 103 of the device, that is, the end intended to be placed in contact with the patient's skin at the injection site. The needle 107a of the syringe 107 will project from said front end 103 through a central opening 133. A return spring 135 is supported with one end against the inner face of the front end 103 of the slide sheath 130 and against the thrust surface chassis 100a with its other end. Laterally, the return spring 135 is guided by the alignment ribs 134 formed within the sheath 130.
[0079] [079] A pair of mounting fasteners 139 extends outwardly from the ends of the extensions 131 to engage by pressure with the axial guide partitions 147 formed along the chassis 100a. The extensions 131 deform when the device is being mounted to allow the mounting clips 139 to engage with the partitions 147 and the axial movement of the sliding sheath 130 while preventing its release.
[0080] [080] Since the drive extensions 131 are slidably engaged with the axial guide partitions 147 formed in the chassis 100a, the sliding sheath 130 can only move axially in the outer body 100 along the inwardly designed axial alignment rails 136 from the inner face of the chassis 100a. Two wide axial openings 137, arranged at 90 with respect to the drive extensions 131, are formed in the sliding sheath 130. The axial openings 137 are axially aligned with the corresponding transparent inspection windows 138 formed in the chassis 100a, through which the drum 107c syringe 107 is visible, where the user can control the drug distribution condition. The support surface for the return spring 135 on the chassis 100a consists of the lower wall 138a of said inspection windows 138. The axial openings 137 allow the sliding sheath 130 to travel axially for the required distance while not touching the windows 138 of the chassis 100a .
[0081] [081] Flexible tips 141 project from diametrically opposite parts of the sliding sheath 130 and have an active sloping surface to provide resistance to the movement of the sliding sheath 130 when it rests against the corresponding internal protuberances 141a at the front end of the rails. axial alignment 136 of the chassis 100a (see figures 30 and 37) and allows this movement only as a result of a moderate thrust that deforms the tips 141 inwards to overcome the protrusions 141a. The movement subsequently created by releasing the tips 141 helps to quickly insert needle 107a from syringe 107 into the injection site.
[0082] [082] A tubular housing 142 for syringe 107 is formed on chassis 110a and an inner edge 142a is formed at the front end, where the front end of drum 107c rests. At the other end of the tubular housing 142 the drum 107c projects with a flange 107e, above which the front face of the cam sleeve 123 is located (see figures 30 and 31).
[0083] [083] As illustrated in figure 37, the guide devices 144 for the radial preachers 115 are engraved on the inner surface of the chassis 100a to control the axial movement of the plunger rod 108 and thereby limit the volume of the dispensed drug. These guiding devices are in the form of a stepped rail with a locating face 144a and a stop protruding 144c, lying in the planes perpendicular to the X axis. The edge of the locating face 144a is connected to the rear edge of the chassis 100a by a first side axial 144d and the stop protrusion 144c by a second axial side 144e. A pair of diametrically opposed staggered rails, symmetrical to the axial rotation with respect to their shape, is formed on the inner face of the chassis 100a. The radial pins 115 of the plunger rod 108 are designed to jump down from a position at the rear of the chassis 100a, where the relative axial position of the pins 115 is defined by the connection of the bayonet attachment between the retaining bases 113 and the drive partitions 112, on the location face 144a in the distribution of the first dose, and to slide on it as a result of the rotation of the cam sleeve 123, finally falling from the location face 144a to the stop protrusion 144c in the distribution of the second dose of the drug, while moving along the first axial side 144d and, respectively, the second axial side 144e, as will be explained later.
[0084] [084] A needle guard remover 145 is removably attached to the sliding sheath 130 by snap-on retaining extensions 145a leaning against a flange at the front end of sheath 130 and is provided with an inner tubular grip element 145b in which an insert 146 is arranged to engage the needle guard 107b via retaining hooks (not shown) digging into the rubber needle guard, such that, by retracting the needle guard remover 145 before the first dose is administered , the user can remove needle guard 107b and release needle 107a for injection.
[0085] [085] The operation of the autoinjector device according to the second embodiment of the invention is described below. As already mentioned, the operation is substantially the same as the previously described embodiment of the invention. Reference is made to figures 42 to 48, the hidden line 148, where present, in these figures indicates the position of the front end of the chassis 100a.
[0086] [086] In the initial state, the stored state, the energy spring 110 is compressed between the closed end of part 108a of plunger rod 108 and the bottom wall 204a of ratchet 204 integral with dose selection button 104. The type connection bayonet between the ratchet 204 and the plunger rod 108 holds the energy spring 110 in compression until the first dose is triggered. Any volume of the energy spring 110 is prevented by the fact that it is disposed between the part 108b of the piston rod 108 and the support rod 111.
[0087] [087] Needle guard 107b is attached to syringe 107 and needle guard remover 145 is attached to needle guard 107b through insert 146. Cap 102 is attached to chassis 100a and slide sheath 130 is prevented from moving axially due to the drive pins 132 of the drive extensions 131 supported against the respective locking edges 129a of the cam sleeve 123.
[0088] [088] The dose selection button 104 is connected to the outer body 100 as the sleeve 100b is held captive between the button 104 and the ratchet 204 integral with each other. Once assembled, the assembly formed by the dose selection button 104 and the ratchet 204 cannot move axially, the blades can only rotate in one direction. The direction of rotation is indicated by the reference marks on the outer body 100: in other words, indicator 105 starts from position 0, rotates to position 1, when the first dose is selected, and then rotates to position 2 when the second dose is selected.
[0089] [089] In the stored state, the device is "locked", that is, the sliding sheath 130 cannot move in the outer body 100, since the driving extensions 131 of the sliding sheath 130 rest against the axial locking edges 129a of the cam sleeve 123. This condition is illustrated in particular in figures 42 and 433a. In fact, by rotating the dose selection knob 104 the cam sleeve 123 is pushed in the same direction by the bases 121 of the ratchet 204 which rest on the front edge 122a of the grooves 122 of the cam sleeve 123 with its rotating extensions 11a. The dose selection knob 104 cannot rotate beyond position 1 until the first dose is dispensed, as the drive pins 132 of extensions 131 rest on the stop edge 128c of cam rail 128 on cam sleeve 123. A sliding sheath 130 is prevented from rotating as extensions 131 can only move axially back and forth in the axial guide partitions 147 in chassis 100a
[0090] [090] It should be noted that, as illustrated in figure 43a, in the resting position there is a Y design space between the trigger cam rail 127a and the respective radial preacher 115. A Z design space of the lower extension exists between the rotating legs 121a of the bases 121 of the ratchet 204 and the respective front edges 122a of the grooves 122 of the cam sleeve 123. When the user turns the dose selection knob 104, in the beginning, he must overcome the resistance opposed by the stop rib 120 of the sleeve 100b leaning against protrusions 120a of ratchet 204 (figure 43c). The small rotation required to do this, puts the rotating extensions 121a in contact with the front edges 122a, while a residual space still exists between the trigger cam rail 127a and the respective radial preacher 115.
[0091] [091] First, the user must slide back and remove end cap 102 in order to expose needle guard remover 145. End cap 102 will need to be replaced once the first dose is delivered when the device is not is in use. End cap 102 protects the drug from exposure to light and prevents particles from coming into contact with the front end 103 of the device.
[0092] [092] To perform the first injection, the user must remove needle guard remover 145. This way, insert 146 and needle guard 107b are also removed leaving needle 107a uncovered, but still below the level of the front end 103 and not readily visible to the user. To unlock the device and select the distribution of the first dose, the user turns the dose selection knob 104 from position 0 (stored state) to position 1 (first armed dose).
[0093] [093] Rotating the dose selection knob 104 from position 0 to position 1 causes the cam sleeve 123 to rotate, where the axial locking edges 129a of the cantilever extensions 129 shift relative to the drive pins 132 of the extensions 131 of the sliding sheath 130, which rest against the upper edge 128c to prevent the knob 104 from turning further until the first dose is distributed and are aligned on the rising parts 128a of the cam rail 128 free to move along them (see figures 43b and 45). The user recognizes the end of rotation for position 1 when he sees that the indicator 105 has aligned with the position marker 1, feels the increase in the rotation resistance of the drive pins 132 by contacting the cam rail 128 and also hears the "click" as produced by toothed extensions 118 clicking as a result of their fall from the relevant ribs 119. The contrast between the extensions 118 and the relevant ribs 119 prevents the reverse rotation of button 104, while any forward rotation is hampered by the support between the stop rib 120 of the sleeve 100b and the protrusion 120a of the ratchet 204 (figure 43c).
[0094] [094] The device is activated by the user pressing the front end 103 of the sliding sheath 130 against the injection site by maintaining the device through the outer body 100. The movement of the sliding sheath 130 in the outer body 100 encounters a resistance due to the contrast between the flexible ends 141 of the sliding sheath 130 and the internal protuberances 141a of the chassis 100a. Due to their flexibility and angled contact surface, the flexible tips 141 press and deform completely inwards while overcoming the protrusions 141a to allow the passage of the sliding sheath 130 that can slide on the chassis 100a leaving the needle 107a to project from its end front 103 so that the needle can penetrate the injection site. The movement subsequently created by releasing the flexible tips 141 helps to quickly insert the needle 107a into the injection site (figure 44a).
[0095] [095] The axial movement of the sliding sheath 130 in the outer body 100 causes the cam sleeve 123 to rotate and the latter would enter by rotating friction also with the ratchet 204 and the dose selection button 104. To prevent the button 104 rotate during the dispensing step of the first dose, between the ratchet 204 and the sleeve 100b, temporary stop devices are provided and engage each other when the free ends of the temporary stop device comprise the stop ribs 120 of the sleeve 100b resting on the corresponding protrusions 120a of the ratchet 204, as illustrated in figure 43c. The rotational force acting on the ratchet 204 upon activation is less than the holding force provided by the stop ribs 120. However, the rotation force that the user can provide is much greater than that of the stop ribs 120. Therefore, the user you can overcome the rib force and turn the knob 104 to arm the device for the second dose.
[0096] [096] The rotation of the cam sleeve 123 causes the piston rod 108 to rotate due to its radial pins 115, engaged in the corresponding axial channels 127 pushed by the trigger cam rail 127a. The angular displacement of the plunger rod 108 causes the bayonet-type connection to disengage as the drive partitions 113 of the plunger rod 108 slide on the respective retaining bases 112 of the ratchet 204 until the partitions 113 are released from the bases 112. This sequence is illustrated in figure 49. At that point, the energy spring 110, no longer retained by the bayonet connection, applies its elastic impulse to the piston rod 108 which moves forward on the cam sleeve 123 until the radial pins 115, sliding in the axial channels 127, incline on the locating face 144a of the step guide 144 of the sleeve 100b (see figure 47a). The axial slip resulting from the plunger rod 108 causes the distribution of the first dose.
[0097] [097] After dispensing the first dose, the user removes the device from the injection site and needle 107a is removed. The return spring 135 is no longer affected by the forced contact between the front end 103 and the injection site and, thus, pushes the sliding sheath 130 axially outwards, thus protecting the needle again. At the same time, the drive pins 132 of the drive extensions 131 slide downward on the downward part 128b of the cam rail 128 by pressing inward on the cantilever extensions 129 until the device returns to a "locked" condition, where the drive 132 come into contact with the free end 129a of the cantilever extensions 129 and the mounting clips 138 of the sliding sheath 130 again engage the end stops 140a on the axial guides 136 of the chassis 100a, as shown in figure 46a.
[0098] [098] Needle 107a is again not accessible as being covered by the sliding sheath 130, which in this state is prevented from sliding until the user turns the dose selection knob 104 to position 2. The user then covers the device again . The end cap 102 snaps into place with the outer body 100 to securely hold the chassis 100a.
[0099] [099] If the delivery of a second dose is necessary, the user unlocks the device to allow access to the sliding sheath 130. To unlock the device, the user must turn the dose selection knob 104 from position 1 (first dose position) armed) to position 2 (second armed dose position) (see figures 46a and 46b).
[0100] [0100] For this purpose, the user must overcome the reaction of the ribs 120 of the sleeve 100b in the protrusions 120a of the ratchet 204. The deformation of the protrusions 120a allows the knob 104 to rotate. The bases 121 of the ratchet 204 occupy the free path in the grooves 122 of the cam sleeve 123 until the rotating extensions 121a reach the front edges 122a to rotate the cam sleeve 123 to position 2, as illustrated in figures 46a and 46b. In this case too, obtaining position 2 is announced by a click as for position 1.
[0101] [0101] Rotation of the cam sleeve 123 causes the device to unlock as the drive pins 132 of the drive extensions 131 of the sliding sheath 130 align with the rising portion 128a of the cam rail 128 while contacting the stop edge 128c to prevent further rotation of button 104 once position 2 is reached. The reverse rotation of the dose selection button 104 is prevented by the toothed extensions 118 supporting by pressure on the protrusions 119 of the sleeve 100b. Rotation of the cam sleeve 123 also causes the radial pins 115 to be repositioned from the outlet of the axial channel 127 within the window 126 to the opposite axial side 126c, while their position on the locating face 144a of the step guide 144 is unchanged (figures 46b and 47a).
[0102] [0102] The device is activated to distribute the second dose by the user by pressing the front end 103 of the sliding sheath 130 against the injection site by maintaining the device through the outer body 100. The movement of the sliding sheath 130 in the chassis 100a caused by the pins drive 132 of the extensions 131 pushing against the rising rail 128a encounters a resistance due to the contrast between the flexible ends 141 of the sliding sheath 130 and the internal protuberances 141a of the chassis 100a. Due to their flexibility and angled contact surface, the flexible tips 141 press and deform completely inwardly overcoming the protrusions 141a to allow the passage of the sliding sheath 130 that can slide on the chassis 100a leaving the needle 107a to project from the front end 103 , so that the needle can penetrate the injection site. The movement subsequently created by releasing the flexible tips 141 helps to quickly insert the needle 107a into the injection site. The thrust produced by the drive pins 132 does not cause any significant axial movement of the cam sleeve 123, due to its positioning flange 124 which is axially supported against the rim 125 of the sleeve 100b.
[0103] [0103] To prevent any further rotation of the button 104, once position 2 is reached, at the end of the next rotation of the cam sleeve 123, the free end of the ratchet extensions 118 rests on the stop ribs 119 thus preventing the reverse rotation of the button 104, while the forward rotation is hindered by the contrast between the stop rib 120 of the sleeve 100b and the protrusion 120a of the ratchet 204 (figure 43c).
[0104] [0104] While the cam sleeve 123 remains in rotation, the radial pins 115 slide on the locating face 144a of the step guide 144 as pushed by the axial side 126c of the window 126 until they reach the end of said face, from where they fall from the stop protrusion 144c of stepped guide 144 due to the action of the energy spring 110. This operational sequence is illustrated in figures 47a to 47 c. The axial slip resulting from the plunger rod 108 causes the second dose to be delivered.
[0105] [0105] After dispensing the second dose, the user removes the device from the injection site and needle 107a is removed. The return spring 135 is no longer impaired by the forced contact between the front end 103 and the injection site and, thus, pushes the sliding sheath 130 axially forward, thus again capping the needle. At the same time, the drive pins 132 of the drive extensions 131 slide downward on the downward track 128b of the drive cam device 128 and press inward on the cantilever extensions 129 until the device returns to a "locked" condition, where the drive pins 132 contact the free end 129a of the cantilever extensions 129 and the mounting clips 139 of the sliding sheath 130 again engage with the end stops 140a on the axial guides 136 of the chassis 100a, as at the end of the first dose distribution. The needle 107a is again not accessible as being covered by the sliding sheath 130. The user then covers the device again with its end cap 102 before disposal or handling by the paramedic.
[0106] [0106] The autoinjector device according to the invention is suitable for dispensing drugs in solution, especially epinephrine (also known as adrenaline).
[0107] [0107] In particular, the doses of epinephrine that can be administered with the device of the invention are preferably in the range of 0.05 mg to 0.5 mg for each dose delivered (from 0.1 mg to 1 mg if two doses are considered).
[0108] [0108] Preferred doses for each distribution are 0.05 mg, 0.10 mg, 0.15 mg, 0.30 mg and 0.50 mg.
[0109] [0109] The above doses are based on a concentration of epinephrine solution preferably ranging from 0.05 mg / ml to 0.5 mg / ml, concentrations of 0.05 mg / ml, 0.1 mg / ml, 0 , 16 mg / ml, 0.3 mg / ml and 0.5 mg / ml are particularly preferred.

权利要求:
Claims (31)
[0001]
Automatic drug injection device, CHARACTERIZED by the fact that it comprises: an outer body (1; 100) extending along a longitudinal axis (X); a group of syringes (6; 106) located in said external body (1; 100) and attached thereto, said group of syringes comprising a syringe (7; 107) containing a drug to be injected, a needle (7a; 107a ) and plunger device (8; 108) axially sliding and articulating with respect to said external body (1; 100); arming device (4; 104; 204) said device from a stored position to a first armed position to inject a first dose and at least a second armed position to inject a second dose, said arming device being arranged in one end of the outer body (1; 100); first elastic device (10; 110) disposed between said arming device (4; 104; 204) and said plunger device (8; 108), said first elastic device being in the compressed condition when the device is in position stored and decompressed to push said plunger device (8; 108) forward and successively distribute said first and said at least second dose; a sliding sheath (30; 130) disposed at the other end of said outer body (1; 100) and restricted to slide axially within it, as a result of pressure exerted on its free end, in contrast to the second elastic device ( 35; 135) disposed between said sliding sheath (30; 130) and said outer body (1; 100), between a sliding locking position, wherein said sliding sheath (30; 130) projects from said external body (1; 100) covering the needle (7a; 107a) of the syringe, and a device trigger position, in which said sliding sheath (30; 130) is retracted in said external body (1; 100) leaving the needle (7a; 107a) of the exposed syringe, said second elastic device (35; 135) being suitable for placing said sliding sheath (30; 130) back in said locked position when said pressure action ceases; drive cam device (28; 128) operatively connected to said sliding sheath (30; 130) and axially articulated in said external body (1; 100); trigger cam device (26, 27; 126, 127) integrally articulated with said actuation cam device and operatively connected to said piston device (8; 108) to angularly move said piston device (8; 108) for said trigger positions of the first dose and at least the second dose; stepped guide device (44; 144) integral with said external body (1; 100) and operatively connected to said piston device (8; 108) to control the extent of axial sliding of said piston device (8; 108) and therefore, to limit the volume of the drug delivered for each dose, said drive cam device (26, 27; 126, 127) and said drive cam device (28; 128) being formed on the same support (23 ; 123) articulated between said external body (1; 100) and said piston device (8; 108).
[0002]
Device according to claim 1, CHARACTERIZED by the fact that said trigger cam device (26, 27; 126, 127) is formed on the external surface of said support (23; 123) and comprises at least one axial partition (27; 127) extending from an end edge of said support (23; 123) and defining a first axial trigger cam rail (27a; 127a) to push said plunger device (8; 108), and at least a second corresponding axial trigger cam rail (26c; 126c) for pushing said plunger device (8; 108) angularly spaced with respect to said first trigger cam rail (27a; 127a).
[0003]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said plunger device (8; 108) comprises at least one radial preacher (15; 115) extending out perpendicular to said axis (X) to interact with said trigger cam device (26, 27; 126, 127) and said stepped guide device (44; 144).
[0004]
Device according to claim 3, CHARACTERIZED by the fact that said plunger device (8; 108) comprises at least one pair of radial pins (15; 115) extending in diametrically opposite parts.
[0005]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said sliding sheath (30; 130) interacts with said drive cam device (28; 128) through free ends (32; 132) of the extensions axial axles (31; 131) extending from said sliding sheath (30; 130).
[0006]
Device according to claim 5, CHARACTERIZED by the fact that said drive cam device (28; 128) is formed on the external surface of said support (23; 123) and comprises, for each of said axial extensions ( 31; 131), at least one first drive cam rail (28a; 128a) extending from the other end of said support (23; 123) and inclined with respect to said axis (X), and at least one second drive cam rail (28b; 128b) extending from the same end of said support (23; 123) and incident with the first drive cam rail (28a; 128a), the free ends (32; 132) of the said axial extensions (31; 131) slidably engaging said first drive cam track (28a; 128a) and successively said second drive cam track (28b; 128b) when a pressure action is exerted at the end free (3; 103) of the sliding sheath (30; 130), where said support (23; 123 ) is rotated in a direction that is inclined to said first drive cam rail (28a; 128a), and, respectively, when said pressure action ceases.
[0007]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said device arming device comprises a dose selection button (4; 104; 204) hingedly connected to said external body (1; 100) in a shape that can rotate in only one direction and temporarily connected to said support (23; 123) to move it angularly to an extension capable of unlocking the device for dispensing a dose.
[0008]
Device according to claim 7, CHARACTERIZED by the fact that said dose selection button (4) comprises at least two diametrically opposed bases (21) engaged with respective sliding seats (22) of said support (23) having a front edge (22a) against which said bases (21) rest to make said support (23) rotate.
[0009]
Device according to claim 7 or 8, CHARACTERIZED by the fact that said dose selection button (4) is equipped with toothed extensions (18) slidably engaged with inclined surfaces (19) formed in said external body ( 1), said inclined surfaces (19) defining the inclined steps (19a) against which said extensions (18) rest when said dose selection button (4) reaches the armed position for dispensing a dose.
[0010]
Device according to claim 9, CHARACTERIZED by the fact that the temporary limiting device (46, 47) is provided between the dose selection button (4) and the outer body (1) to engage each other when the free ends of the toothed extensions (18) fall from the step (19a) of the inclined surface (19) of the external body (1).
[0011]
Device according to any one of claims 1 to 6, CHARACTERIZED by the fact that said arming device comprises a dose selection button (104) and a ratchet (204) disposed within said dose selection button (104) and snapped into it, said ratchet (204) being hingedly connected to said external body (100) so that it can be rotated in just one direction and temporarily connected to said support (123) to print a angular displacement to unlock the device for a dose distribution.
[0012]
Device according to claim 11, CHARACTERIZED by the fact that said ratchet (204) comprises at least two diametrically opposed bases (121) engaged with the respective sliding seats (122) of said support (123) having a front edge ( 122a) against which the rotating extensions (121a) of said bases (121) rest to make said support (123) rotate.
[0013]
Device according to claim 12, CHARACTERIZED by the fact that a design space (Y) exists between the trigger cam rail (127a) and the respective radial nail (115) and an extension design space (Z) the smallest exists between the rotating extensions (121a) of the bases (121) and the respective front edges (122a) of the grooves (122), where the rotation of the dose selection knob (104) to set the device for the first dose does not cause the plunger device (108) to rotate.
[0014]
Device according to any of claims 11 to 13, CHARACTERIZED by the fact that said turnstile (204) is equipped with flexible extensions (118) configured to slide under flexion, as a result of the rotation of the dose selection button ( 104), in respective ribs (119) of said external body (100), and to jump the support against them with their ends, where the reverse rotation of the dose selection button (104) is prevented when the dose selection button dose (104) reaches the armed position for dispensing a dose.
[0015]
Device according to claim 14, CHARACTERIZED by the fact that the reversible limiting device (120, 120a) is provided between the ratchet (204) and the external body (100), to support against each other when the free ends of the flexible arms (118) rest against the rims (119) of said external body (100).
[0016]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said drive cam device (28; 128) comprises projected cantilever extensions (29; 129) capable of deforming to allow said sliding sheath (30 ; 130) slide with respect to said support (23; 123) when the pressure action on said front end (3; 103) ceases and to prevent this from occurring before said dose selection button (4; 104; 204) be positioned in an armed dose selection position.
[0017]
Device according to claim 16, CHARACTERIZED by the fact that each of said cantilever extensions (29; 129) is arranged on a second respective drive cam rail (28b; 128b) and its free end constitutes the locked edge (29a; 129a) against which the end (32; 132) of the axial extension (31; 131) rests when the device is in the locked condition.
[0018]
Device according to claim 17, CHARACTERIZED by the fact that a limiting edge (28c; 128c) is located laterally with respect to said axial locking edge (29a; 129a) to serve as support for said ends (32; 132 ) to prevent the dose selection knob (4; 104, 204) from rotating beyond the positions of the first dose and second dose distribution.
[0019]
Device according to any of the preceding claims, CHARACTERIZED by the fact that a bayonet connection is provided between said arming device (4; 104, 204) and said plunger device (8; 108) to make them axially integral in said stored position and to release them in said operational dose distribution conditions.
[0020]
Device according to claim 19, CHARACTERIZED by the fact that said bayonet connection comprises at least one retaining fastener (13) of the dose selection button (4) and a substantially L-shaped partition (12) formed by a circumferential retention partition branch (12a) and an axial release partition branch (12b) in said piston device (8), in the stored device position said retention fastener (13) being engaged in said retaining partition (12a) to oppose the thrust of said first elastic device (10), following an angular displacement of said dose selection button (4) said retaining fastener (13) sliding along said partition branch retainer (12a) when passing from said stored position to said first dose distribution position until it aligns axially with said release partition branch (12b), where said delivery device plunger (8) can move axially with respect to said dose selection button (4).
[0021]
Device according to claim 19, CHARACTERIZED by the fact that said bayonet connection comprises a pair of retaining bases (112) projected inwards from said ratchet (204) in diametrically opposite parts and corresponding drive partitions (113 ) extending from said piston rod (108) and securing the retaining bases (112).
[0022]
Device according to claim 2, CHARACTERIZED by the fact that said stepped guide device (44) comprises locating surfaces (44a, 44b) for said piston device (8) located in planes perpendicular to said axis (X ), said piston device (8) being angularly displaced as a result of the pushing action exerted by said axial cam tracks (27a, 26c) along said locating surfaces (44a, 44b) and then axially displaced once that the end of said locating surfaces is reached.
[0023]
Device according to claim 22, CHARACTERIZED by the fact that said guide device (44) comprises at least one stepped guide profile comprising two locating surfaces (44a, 44b) and a limiting protrusion (44c) connected by two axial profile parts (44d, 44e).
[0024]
Device according to claim 22 or 23, CHARACTERIZED by the fact that said stepped guide device (44) is formed on the inner face of said external body (1).
[0025]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said external body (100) comprises a chassis (100a) axially engaged within an external sleeve (100b) and integral thereto, said sliding sheath (130) being axially sliding in said chassis (100a), said support (123) being axially disposed in said outer sleeve (100b), the axial extensions (131) of said sliding sheath (130) being slidably engaged in the axial partitions (147 ) of said chassis (100a), said outer sleeve (100b) being hingedly connected in only one direction to said turnstile (204).
[0026]
Device according to claim 25, CHARACTERIZED by the fact that said stepped guide device (144) is formed on the inner face of the chassis (100a) and comprises a locating surface (144a) and a bounding protrusion (144c) connected by an axial profile part (144d, 144e).
[0027]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said sliding sheath (30; 130) comprises flexible points (41; 141) along its external surface to support against a protuberance of said external body (1 ; 100) to provide resistance to relative axial slip and internally deform under moderate force exerted through said protuberance, the elastic release of said flexible tips to the undeformed condition by exerting an impulse in accordance with the pressure action causing the sliding sheath (30; 130) slide towards the inside of said external body (1; 100).
[0028]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said first elastic device comprises a spring (10; 110) located within said piston device (8; 108) around a support rod (11 ; 111) extending between said arming device (4; 104, 204) and said plunger device (8; 108).
[0029]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said external body (1; 100) is formed with at least one transparent inspection window (38; 138) to control the condition of drug distribution, a corresponding axial opening (37; 137) axially aligned with said window (38; 138) being formed in said sliding sheath (30; 130).
[0030]
Device according to any one of the preceding claims, CHARACTERIZED by the fact that said needle (7a; 107a) is covered by a needle guard (7b; 107b) and a needle guard remover (45; 145) is attached removably to the outer body (1; 100) and be provided with an internal tubular grip (45b; 145b) fitted to engage with the needle guard (7b; 107b), where, by retracting the needle guard remover (45 ; 145) before the first dose is administered, the user can remove the needle cover (7b; 107b) and release the needle (7a; 107a) for injection.
[0031]
Device according to claim 30, CHARACTERIZED by the fact that said needle guard remover (145) comprises an insert (146) having hooks that dig into the needle guard (107b).

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同族专利:

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IL231396D0|2014-04-30|

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JP2014526291A|2014-10-06|

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IL231396A|2017-07-31|

PL2753382T3|2016-06-30|

MY167129A|2018-08-13|

JP5972378B2|2016-08-17|

DK2753382T3|2016-02-29|

GEP20166466B|2016-04-25|

PE20141619A1|2014-11-28|

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NZ623615A|2015-01-30|

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法律状态:
2018-12-11| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

2019-10-29| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

2020-08-18| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2020-09-24| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/09/2012, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

IT000194A|ITFI20110194A1|2011-09-08|2011-09-08|MEDICINE DOSES SELF-INJECTION DEVICE|

ITFI2011A000194|2011-09-08|

PCT/EP2012/067438|WO2013034651A1|2011-09-08|2012-09-06|Device for automatic injection of drug doses|

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