巴西专利BR112014005345B1 SYSTEM FOR PACKING DOSED QUANTITIES OF SOLID DRUG PORTIONS; AND METHOD FOR DOSING SOLID DRUG PORTION

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专利摘要:
system for packaging metered quantities of solid drug portions; and method for dosing solid drug moieties is a system for packaging metered quantities of solid drug moieties comprising a plurality of dosing stations (2) for dispensing a metered amount of solid drug moieties, a plurality of ducts of targeting (7), a plurality 10 of collection containers (17) coupled to receive directed drug portions through the targeting ducts (7), and at least one packaging and discharging station (3) for transferring collected drug portions for each collection container (17) to a package and to close the package. the targeting ducts (7) are coupled to a means of transport (6a, 6b, 8, 10, 11, 12, 15, 16) to move the targeting ducts (7) along the metering stations (2), each targeting duct (7) being adapted to receive portions of drug distributed to 20 from at least one of the dosing stations (2) when the targeting duct (7) is positioned in at least one dosing station (2 ), and to guide the drug portions received to an opening opening of the targeting duct (7). the collection containers (17) are also 25 coupled to the means of transport (6a, 6b, 8, 10, 11, 12, 15, 16) so that each collection container (17) can be positioned in the feed passage opening one of the targeting ducts (7) to receive targeted drug portions through the targeting duct (7).
公开号:BR112014005345B1
申请号:R112014005345-6
申请日:2012-08-31
公开日:2020-06-02
发明作者:Arie Van Wijngaarden
申请人:Carefusion Switzerland 317 Sàrl；
IPC主号:

专利说明:

SYSTEM FOR PACKING DOSED QUANTITIES OF SOLID DRUG PORTIONS; AND METHOD FOR DOSING SOLID DRUG PORTIONS
[001] The present invention relates to a system for packaging metered quantities of solid drug portions. The invention also relates to a method for dosing solid drug portions, in particular using a system according to the invention.
[002] It is usually advantageous to pack dosed quantities of solid drug portions, such as tablets, capsules, pills and pills, in bags, pouches or other types of packaging, where the drug portions in each bag are packed separately if swallowed, in that the bag is endowed with user information, such as the day and time of day when the drug portions are to be taken. The bags for one user are usually attached to each other and filled in a distribution box.
[003] The filling of individual packages with metered quantities of solid drug portions (batches) has been increasingly automated. A known system for dosing solid drug portions for final packaging in individual packages comprises a plurality of supply containers, each provided with different types of drugs. After reading or inserting a drug prescription, the supply containers relevant to the prescription are opened to allow a metered amount of drug portions to fall into a central drop duct positioned under the supply containers. At the bottom of the drop duct, selectively released drug portions are collected and sent
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2/31 stops and filled in a package, such as a bag or pocket, after which the package is closed. The delivery of the package with user information can be done here before or after filling the package. 60 packages per minute can be produced in this automated way.
[004] However, the known system has several disadvantages. A significant disadvantage of the known system is that the rate or frequency of filling the system depends to a considerable extent on, and is limited by, the (longest) time of dropping of the drug portions in the dropping duct, through which the frequency of filling the known system is limited and cannot be increased. In other words, a filling cycle for a next bag can start only after the filling cycle for a present bag has been expected to complete, that is, after the expiration of the maximum expected time for a portion of drug to fall out of the supply container. farther (higher) along the drop duct to the bottom and the packaging. However, due to the ever increasing demand for drug portions, there is a need in practice to provide more packs of metered amount of drug portions per unit time.
[005] For example, US5709063 demonstrates a device and method for continuously packaging portions of drugs. The device comprises a plurality of tablet feeders, arranged before several discharge channels. The discharge channels end in a central hopper from which the drug portions are directed to the device's packaging machine. Due to the central funnel, only one
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3/31 drug portion composition can be collected at any given time.
[006] Document DE9001113.9 demonstrates a device for collecting the composition of the drug portion. The device also comprises a plurality of tablet feeders. The device also comprises a plurality of tablet collectors. However, the device comprises only one discharge channel to guide the tablet from the feeders to the collectors, so that only one composition of drug portions can be collected at a time.
[007] It is an objective of the invention to increase the filling rate or frequency.
[008] This objective is achieved according to the present invention by a system for packaging metered quantities of solid drug portions according to claim 1. Furthermore, this objective is accomplished by a method according to claim 24.
[009] The system according to the invention for packaging metered quantities of solid drug portions comprises: a plurality of dosing stations for delivering a metered quantity of solid drug portions, a plurality of targeting ducts coupled to a means of transport to move the targeting ducts along the dosing stations, where each targeting duct is adapted to receive portions of drug distributed from at least one of the dosing stations when the targeting duct is positioned in at least one of the targeting stations. dosage, and to direct the received drug portions to an opening in the
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4/31 targeting, a plurality of collection containers coupled to the means of transport so that each collection container can be positioned in the through opening of one of the targeting ducts to receive at least portions of drug directed through the targeting duct a packaging and unloading station for transferring portions of drug collected by each collection container to a package and to close the package.
[010] By applying mobile combinations of targeting means and collection containers, which in fact function as temporary packaging, allows multiple drug prescriptions to be collected in parallel (simultaneously) instead of in series (successively), through which the frequency for filling packaging can be increased substantially. While the dosed quantity of solid drug portions is moved through a targeting duct, for example, it falls through a dropping tube, the targeting duct (eg, dropping tube) and an underlying collection container can be moved continuously, usually towards one or more of the following dosing stations (for example, vertical columns of dosing stations) which - depending on the prescription to be followed - can be optionally activated for the purpose of dispensing a metered amount of portions of drug. Preferably, each collection container is adapted to collect a prescription usually associated with a user and a day and time when the drug portions of that prescription should be taken. A prescription here consists of a predefined type and quantity of solid drug portions, for example, formed by tablets, capsules or
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5/31 pills. A supply of different types of solid drug portions is maintained at different dosing stations. The distance between the outlet of each dosing station and the corresponding inlet of the directing ducts (drop tubes) that collaborates with each dosing station is preferential and substantially constant, so that the time required to transfer portions of drug from the dispensing stations dosing to the adjacent ducting ducts (drop tubes) is substantially the same, making it possible to move the ducting ducts with the collection vessels at substantially constant speed.
[011] In a preferred embodiment, the dosing stations are arranged in a plurality of parallel columns, in which each column comprises a plurality of dosing stations, in which each targeting duct is adapted to receive portions of drug distributed from the one-column dosing stations when the targeting duct is positioned on the dosing station column. Preferably, the metering stations are arranged in a plurality of vertical columns and each directing duct consists of a vertical drop tube. This simplifies the construction of the means of transport and the frame that carries the dosing stations. The width of a drop pipe in the direction of transport preferably corresponds to the width of a metering station. This allows dosing stations to have a maximum capacity with limited installation space.
[012] Dosing stations generally take a stationary form. It is advantageous here that a plurality of dosing stations are positioned adjacent to each other.
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6/31 si, which allows the simultaneous filling of a plurality of collection containers. It is also advantageous for a plurality of dosing stations to be positioned above each other, through which multiple types of drugs can be distributed simultaneously to the same drop tube and subsequently to the same collection container, which also accentuates the frequency of filling the system. It is particularly advantageous here that at least several of the dosing stations are arranged in a matrix structure with dosing stations arranged in multiple horizontal rows and multiple vertical columns. It is advantageous here that the dosing stations are positioned as close to each other as possible, which, in addition to saving volume, also results in time savings when filling the collection containers. It is also possible to envisage the application of a plurality of matrix structures of dosing stations in order to further increase capacity. In a particular embodiment, the system comprises two matrix structures, where each matrix structure comprises a plurality of dosing stations arranged in rows and columns, and on which distribution sides of the dosing stations of the two matrix structures are facing one To the other. Due to this orientation, several drop tubes are closed by the two matrix structures.
[013] In one embodiment, the collection containers can be a part of the drop tubes (which form the targeting ducts) or each collection container can be attached or mechanically coupled to a drop tube, so that the transport move the drop tubes
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7/31 together with the collection containers. However, in a preferred embodiment, the means of transport comprises a first endless conveyor and a second endless conveyor, the drop tubes being coupled to the first endless conveyor and the collection containers being coupled to the second endless conveyor. In this embodiment, it is possible to move a collection container away from the drop tube, if the drop tube has passed through all dosing stations and all dispensed drug portions have left the drop tube and reached the collection container.
[014] By causing the drop tubes to move around the two matrix structures of dosing stations, and thus, across all dosing stations, the required drug portions can be collected relatively effectively.
[015] In one embodiment, the first endless conveyor comprises two parallel endless conveyor belts. In order to stabilize the movement of the fall pipes, it is usually advantageous that the system comprises a plurality of endless conveyor belts, oriented in a substantially parallel manner, in which each fall pipe is connected to a plurality of first conveyor belts. This stability, and particularly stability in the vertical direction, can be further increased when the system comprises at least one stationary guide, such as a rail, to direct the movement of the fall pipes.
[016] In one embodiment, the system comprises drive means for driving the first conveyor
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8/31 endless and the second endless conveyor with the same transport speed. The drive means preferably comprises at least one electric motor. It is advantageous here that the drive means are adapted to drive both the first conveyor and the second conveyor simultaneously. It is possible for this purpose to conceive that the at least one first conveyor and the at least one second conveyor are mechanically coupled to each other. This coupling is preferably such that both conveyors are moved in the same direction and at the same speed. In this way, the constant alignment between the drop tubes and the collection containers can be guaranteed as much as possible. In one embodiment, the width of a collection container in the direction of transport substantially corresponds to the width of a direction duct in the direction of transport. A collection container and a drop tube that rests above are, however, preferably not physically connected to each other or even manufactured as a single piece, since the decoupling of the two components enhances the flexibility of the system.
[017] Physically separating the collection containers from the drop tubes makes it possible to direct the collection containers away from the drop tubes. In a preferred embodiment, the physical length of the second conveyor is greater than the length of the first conveyor so that the number of collection containers attached to the second conveyor is greater than the number of drop tubes attached to the first conveyor. This makes it possible to direct the collection containers over one or more other types of (special) dosing stations
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9/31 for direct distribution of portions of drug in the collection containers, therefore not through drop tubes. Such special dosing stations can be advantageously used, for example, when special drug portions, with drug portions that are dosed less frequently, are applied. In an advantageous embodiment, each special dosing station comprises a supply drawer coupled to a carrier frame in such a way that the supply drawer can be moved. It is possible here to conceive the application of a plurality of such supply drawers mechanically coupled to each other. This makes it possible to position a supply drawer above the collection containers for the purpose of dispensing portions of drug, while another supply drawer is positioned at a greater distance from the collection containers to allow refilling. It is advantageous for this purpose that each supply drawer is detachably coupled to the (same) carrier frame.
[018] The first carrier and second carrier will generally have a substantially horizontal progression. It is advantageous for each drop pipe to be coupled to the first conveyor in a suspended manner. This is due to the fact that the first conveyor will generally be formed by a relatively tightly tensioned belt around two or more steering wheels, with each steering wheel rotating around a vertical rod, through which the surface support (width) of the belt extends in a substantially vertical direction and can work with the purpose of
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10/31 relatively stable. It is possible here to design, and it is usually advantageous, that each fall tube is detachably coupled to the first conveyor, thus facilitating the replacement and maintenance of the fall tubes. For the same reason, it is advantageous that each collection container is coupled in a suspended manner to the second conveyor. It is also advantageous here that each collection container is detachably coupled to the second conveyor in order to facilitate replacement and maintenance.
[019] A collection container will generally be considered a drug portion transport that works for the purpose of collecting a prescription and transporting the collected drug portions to the packaging and unloading station. It is usually advantageous here that an upper side of each collection container takes an open shape and is adapted to receive a metered amount of drug portions that fall from a dosing station via a drop tube. The collection container also acquires the function of a collection tray. A underside of each collection container preferably comprises a controllable closure element to allow removal of the collected drug portions. The closing element can be mechanically controllable at the packaging and unloading station. The closing element is, however, preferably controllable in a non-contact manner, more preferably by applying magnetism. At least a part of the closing element must be provided, however, a magnetic or magnetizable form for this purpose. The operation of such a closing element, for example, can be performed by applying an electromagnet or permanent magnet to the
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11/31 packaging and unloading station. In an advantageous embodiment, the collection container comprises tilting means, for example, a compression spring, to propel the closing element towards a closed state, through which the incorrect opening of the closing element can be prevented. The discharge station can in fact form part of the packaging station, in which the distribution of drug portions collected in a collection container to a closure package can be followed almost immediately by closing said package.
[020] As each collection container collects its own prescription, it is desirable to know the location of the drop tubes and collection containers in relation to the dosing stations. For this purpose, a calibration module can be used to calibrate the positioning of at least one drop tube in relation to the first conveyor and / or at least one collection container in relation to the second conveyor. The system can be calibrated by determining a calibration point or reference of at least one drop tube and / or collection container, since the sequence and speed of transport of the drop tubes and collection containers are previously known, as is the length of the first conveyor and the second conveyor. Recognition of a drop tube and / or collection container by the calibration module can occur, for example, by providing the drop tube and / or collection container with a unique identification. However, it is also possible to conceive the non-identification of the fall tubes and / or collection containers, but consider the fall tube and / or collection container
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12/31 detected at a time determined by the calibration module as a drop tube and / or collection container that serves as a reference.
[021] As already stated, at least several dosing stations are arranged adjacent to each other, which facilitates the filling of several - also mutually adjacent - collection containers. It is advantageous here that the width of a collection container corresponds substantially to the width of a drop tube, and that the width of a drop tube corresponds substantially to the width of a dosing station, through which the (mutually adjacent) dispensing stations dosage, on the one hand, and the (mutually adjacent) collection containers, on the other hand, can be properly aligned relative to each other, which enhances the reliability of the filling process. A typical width for the dosing station, drop tube and collection vessel is 80 mm.
[022] The packaging station is preferably adapted to seal the packaging. The sealing is understood to mean substantially tight medium closure of the package in order to allow the best possible conservation of the packaged drug portions. A sheet of metal (plastic) will generally be applied as packaging material and the seal will be formed by a welding process. A separate adhesive, in particular glue, can optionally be applied instead of a solder for the purpose of sealing the packaging. The packaging station is most preferably adapted to make at least one longitudinal seal and at least one cross seal, through which bags are formed which are mutually exclusive.
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13/31 connected and thus forming a strip. As the packaging station is preferably adapted to carry out a transverse seal, the length of the bag to be formed can be determined and preferably made dependent on the number and / or type of drug portions to be packed in a bag. The packaging station will generally be placed at a (horizontal) distance from the dosing stations, through which the heat generated by the packaging station will not be transferred, or will hardly be transferred, to the dosing stations and the drug portions kept in them. , which increases the useful life of the drug portions. The packaging station is also usually equipped with a printer to have a specific identification on each package formed.
[023] Each dosing station preferably comprises at least one supply container for portions of drug, for example, in tablet or capsule form, and a dosing device that connects to at least one supply container. The dosing station as such is also commonly referred to as a reservoir. The dosing device is adapted to separate one or more single drug portions from the drug portions present in the supply container. Dosing can occur by selectively removing the separate drug portions, generally allowing them to fall out of the dosing device. In an advantageous embodiment, the dosing device is displaceable in relation to the supply container between a loading state, in which a receiving space of the dosing device connects to a delivery opening of the supply container, and a
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14/31 unloading state in which the dosing device covers the delivery opening and is adapted to deliver the separate drug portion to a collection container coupled to the carrier. The dosing device will generally be substantially cylindrical in shape, with one or more receiving spaces being arranged in the cylindrical dosing device, each receiving space being generally adapted to temporarily retain a portion of drug. Such a dosing device is also commonly referred to as an individualization wheel. Through axial rotation of the cylindrical metering element, the metering element can be moved between a loading state, in which a receiving space of the metering device is aligned with a delivery opening of the filling container, and a unloading state , in which the dosing device covers the delivery opening and is adapted to deliver the separate drug portion to a drop tube coupled to the first conveyor. In a particular preferred embodiment, the dosing station comprises an electric motor, in particular a servomotor or stepper motor, for displacing the dosing device in relation to the supply vessel. A stepper motor is particularly suitable for the present invention due to the fact that the number of rotations performed on it and, therefore, also the displacement of the metering device, can be regulated very precisely. When, as described above, an electric drive is used, a measuring element (sensor) can be applied to measure the resistance produced and / or the current consumed by the electric motor, through which it is possible to detect whether a portion
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15/31 drug was trapped between the supply container and the dosing device. The metering device preferably here comprises at least one indicator, such as a lamp, for generating a signal when the degree of filling of the supply container is below a predefined minimum value. For the purpose of controlling the electronic devices in the dosing station, the dosing station preferably comprises a station control to deliver a metered amount of drug portions on demand. The station control can be particularly adapted here to invert the electric motor if the resistance detected by the measuring element exceeds a predefined value. In the event that a drug portion is trapped between the supply container and the dosing device, the direction of travel of the dosing device can thus be reversed, through which the trapping can be resolved. Each supply container will generally comprise a housing and a cover that closes the housing. It is advantageous here that an external side of the housing is provided with at least one receiving space for a medicine in tablet form which is representative of the drug portions in tablet form received in the housing. The receiving space can be covered here, for example, by a transparent element, so that the pill or tablet received in the receiving space is directly visible from the outside, through which it is immediately apparent what type of medicine is being kept. by the supply container. The provision of the receiving space in the accommodation is preferable to the provision of the receiving space in the roof, since
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16/31 The cover is generally not connected in a detachable manner from the housing and can therefore be exchanged for another cover, which could result in an incorrect indication of the contents of the supply container and, as a consequence, dangerous situations. The dosing device preferably comprises at least one sensor for detecting the moment when a portion of drug (e.g., tablet medicine) delivered by the dosing station falls. Not only can the correct operation of the supply container, and in particular a dosing device received therein, be determined based on the detection of that dropping moment, it is also possible to monitor that a supply container is no longer delivering portions of drug and therefore, it is normally empty. If the sensor detects that insufficient medication is being delivered to the drop tube, and subsequently to the collection container, the entire contents of the drop tube in the dispensing station will be discarded, after which - following the filling of the empty dosing station and / or activation of another dosing station with the same type of medication - the same prescription will be collected again in a collection container. In this way, it is possible to prevent portions of drug with different expiration dates from being placed in the same package, which is undesirable from a health-related point of view.
[024] The number of collection containers is preferably greater than the number of columns of dosing stations. In a typical embodiment of the system according to the invention, the system comprises up to 3,000 columns of dosing stations and up to 4,500 collection containers. In
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17/31 a preferred modality, the system comprises 500 columns of dosing stations and 750 collection containers. An advantageous ratio of the number of collection containers to the number of columns in the dosing stations is 3: 2. Different dosing stations are provided here with different solid drug portions. However, it is also possible to design a supply of frequently used drug portions, such as paracetamol, which are maintained in a plurality of dosing stations.
[025] It is usually advantageous that the system comprises at least one cleaning station for periodic cleaning of drop tubes and / or empty collection containers. The cleaning station can connect here to the first conveyor and / or the second conveyor, through which the drop tubes and / or collection containers do not need to be uncoupled. Cleaning of empty drop tubes and / or collection containers can occur each time an empty drop tube and / or collection container passes through the cleaning station. However, collection containers will generally be cleaned once every 8 to 36 hours at the cleaning station. Cleaning preferably occurs by applying acetone (propanone) in order to remove possible drug residues. Blowing medicine residues out of the collection containers with air is also an option, but is usually less recommended due to the fact that blown medicine residues can then find a relatively easy path to other collection containers, and this is undesirable.
[026] The system preferably comprises a control unit to control at least the station
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18/31 packaging and unloading, dosing stations, the first conveyor and the second conveyors. It is advantageous here that the control unit is adapted to determine, based on a desired metered amount of drug portions for packaging, a metered amount of drug portions to be successively distributed over time by a plurality of dosing stations by means of from drop tubes to collection containers. As prescriptions are taken as a starting point, a logistical conversion must be to a - more effective - method of filling the collection containers, the conversion of which can be done using the control unit. The control unit can comprise a computer provided with a computer program, the computer program being adapted to determine a filling schedule for filling the collection containers and subsequently the packaging at the packaging station.
[027] In addition, the method according to the invention for dosing solid drug portions using a system according to the invention, comprises: A) receiving a prescription with a desired amount of solid drug portions, B ) determine, based on the prescription, the quantity of solid drug portions to be distributed by at least one dosing station to a selected collection container, C) moving the targeting ducts through the means of transport and causing the dosing stations to distribute the determined quantity of drug portions in a targeting duct that moves along the respective dosing stations for the purpose of directing the solid drug portions distributed in the container
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19/31 selected collection, D) having the collection container moved by means of transport to a packaging and unloading station, and E) having the dosed quantity of solid drug portions delivered by the collection container at the packaging station and discharge. During step E) the dosed quantity of solid drug portions delivered by the collection container is usually packed here in a package optionally already provided with user information. Advantages and variations of modality of the method according to the invention have been discussed exhaustively previously. During step A) a plurality of prescriptions are generally received, in which, during step B), each prescription is linked to a selected collection container. A plurality of dosing stations are also generally applied, in which, during step C), a metered amount of drug portions is distributed simultaneously to a plurality of dosing stations by means of at least one targeting duct (e.g. drop tube) to select collection containers. In a variation of modality, the determination of the quantity of drug portions to be distributed to at least one dosing station in a collection container selected based on the prescription during step B) occurs with the use of a control unit. It is also generally used here during step B) of a computer program that comprises program instructions to perform the required calculation with a computer. The control unit and the computer can be at least partially integrated with each other here. The number of drug portions delivered by each dosing station is preferably counted during step C). Thus, it is
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20/31 it is possible to monitor whether a dosing station is empty, and it is also possible to calculate how many portions of drug the dosing station still has stored. The drug portions collected by a collection container during step E) are generally discarded if, during step C), few solid drug portions have been distributed to the associated collection container. It is not recommended to replenish this incomplete prescription with a similar type of solid drug portion missing from another dosing station, since the same type of solid drug portion has the same expiration date on the final packaging.
[028] Preferred and / or advantageous embodiments of the invention are characterized in the dependent claims.
[029] THE invention will be elucidated based on in exemplary modalities non-limiting shown in following figures. At the gift document:[030] THE Figure 1 is a first look in
perspective of a system according to the invention for transporting metered quantities of solid drug portions from a plurality of dosing stations to a packaging station,
[031] THE Figure 2 is a second View in perspective of agreement system with Figure 1, [032] THE Figure 3 is a view of bottom of system according to The figure 1, [033] THE Figure 4 is an side view of the system
according to Figure 1,
[034] Figure 5 is a perspective view of system 1, as shown in Figures 1 to 4,
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21/31
[035]
The Figure is a rear perspective view of a dosing station for use in a system as shown in the Figures
[036]
The Figure is a front perspective view of the dosing station, as shown in
Figure 6
[037]
Figure 8 is a perspective view of a collection container for use in a system
1, as shown in Figures 1 to 4
[038]
Figure is a side view of the collection container according to the
Figure 8
[039]
The Figure is
a front perspective view of the packaging and unloading station as applied to a system, as shown in Figures 1 to
[040]
Figure 11 is a rear perspective view of the packaging and unloading station according to Figure 10, as per control
[041] applied
[042] on
Figure 12 a system
Figure 13 of four stations shows a drop tube according to Figures 1 a is a schematic example of dosing based on four prescriptions received for four patients.
[043] Figures 1 and 2 show different perspective views, Figure 3 shows a bottom view and Figure 4 shows a side view of a system 1 according to the invention for transporting metered amounts of solid drug portions from one plurality of dosing stations 2 to a packaging station 3. The system 1 comprises, for this purpose, a support structure 4
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22/31 (frame) to which a plurality of metering stations 2 are connected in a detachable and stationary manner. Each dosing station 2 is adapted here to retain a supply of one type of drug (pharmaceutical). Different dosing stations 2 will generally retain a supply of different types of drugs, although it is also possible to conceive that frequently dosed drugs are retained by a plurality of dosing stations 2. The majority of the applied dosing stations 2 is arranged in two matrix structures 5 (of which only a single matrix structure is shown in the Figures), whose matrix structures 5, together, comprise a part of the first two horizontal conveyor belts 6a, 6b for guiding ducts in the form of fall 7. The fall pipes 7 are detachably mounted here on mounting elements 8 that form part of both first conveyor belts 6a, 6b. In the exemplary embodiment shown, only a few drop tubes 7 are shown, although in practice each mounting element 8 is generally connected to a drop tube 7, through which the first conveyor belts 6a, 6b are provided all the way around with drop tubes 7. The first conveyor belts 6a, 6b are driven by drive wheels 9 which are coupled by means of a vertical rod 10 to an electric motor 11. In order to be able to prevent the conveyor belts 6a from sliding, 6b, the travel surfaces 12 of the drive wheels take a profiled shape. By driving the first conveyor belts 6a, 6b the drop tubes 7 can be directed along the metering stations 2 arranged in
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23/31 matrix structures 5 for the purpose of receiving metered quantities of drug portions distributed over dosing stations 2. Each drop tube 7 is adapted here for simultaneous collaboration with a plurality of dosing stations 2 positioned one above the other. Each fall tube 7 is provided for this purpose with several through openings (or inlet openings) 13 that correspond to the number of dosing stations 2 in a vertical column, with which the fall tube 7 will collaborate simultaneously. The fall tube 7 is also provided with several braking walls 14 to limit the maximum free fall length of falling solid drug portions, in order to limit the fall speed and thereby limit damage to the drug portions falling (see Figure 12). A maximum free fall length of 20 cm is generally used here. System 1 also comprises a second conveyor belt 15 provided with mounting elements 16 in which a plurality of collection containers 17, also referred to as drug carriers, are detachably mounted. Each mounting element 16 will generally be provided here with a collection container 17 adapted for temporary storage of a metered amount of drug portions produced according to a prescription. Not all collection containers 17 are shown in the figures. The second conveyor belt 15 is mechanically coupled to the first conveyor belts 6a, 6b and is also driven by an electric motor 11, in which the direction of travel and travel speed of conveyor belts 6a, 6b, 15 are the same. Furthermore, it is advantageous that the first conveyor belts 6a, 6b and the second belt
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24/31 conveyor 15 are mutually aligned, where mounting elements 8, 16 rest on a substantially vertical line (one directly below the other). The distance between adjacent mounting elements 8, 16 equals 80 mm, where this substantially corresponds to the width of collection vessels 17, drop tubes 7 and dosing stations 2. Collection vessels 17 are adapted to receive drug portions which fall through drop tubes 7. Each drop tube 7 is provided for this purpose on a underside with a passage opening for falling drug portions. For a part of the transport route, each collection container 17 will be positioned here directly under a drop tube 7. In order to be able to avoid as far as possible the conveyor belts 6a, 6b, 15 due to the weight of respectively drop tubes 7 and collection containers 17, conveyor belts 6a, 6b are tensioned at an inclination of about 600 N. Conveyor belts 6a, 6b, 15 are generally made from a relatively strong plastic, such as polyamide (nylon) . As shown in the figures, the second conveyor belt 15 is longer than each of the first conveyor belts 6a, 6b. The advantage of this is that collection containers 17 can still be transported along and / or under one or more special dosing stations (not shown), preferably made up of drawers, provided with special drug portions - less frequently administered - whose special dosing stations 2 are adapted for direct delivery of selected drug portions to collection containers 17, and not via drop tubes 7. Collection containers 17
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25/31 will then be directed towards the packaging and unloading station 3 in which the drug portions collected according to the prescription are discharged from collection containers 17, in which the drug portions are transferred to a metal foil package open 18. At the packaging station 3 the foil packaging 18 will be successively sealed and provided with specific information (user). The general control of system 1 is carried out by applying a control unit 19.
[044] Figure 5 is a perspective view of the supporting structure 4 provided with conveyor belts 6a, 6b, 15 of system 1, as shown in Figures 1 to 4, this in fact forms the heart of system 1 in which the tubes droppers 7 and collection containers 17 are mounted and in the vicinity of which the dosing stations 2 are then positioned on both longitudinal sides of the supporting structure 4.
[045] The figure 6 is back view in perspective of a season in dosage 2 for use in one system 1, as shown in Figures 1 to 4. The station in dosage 2 is also referred to as a reservoir, formed per
a unit which can be detachably coupled to the support structure 4 and which comprises a housing 20 and a cover 21 which closes the housing 20. The housing is preferably manufactured at least partially from a transparent material, so that the degree of filling of the dosing station 2 can be determined without opening the dosing station 2. An external side of the housing 20 is provided with a receiving space 22 for a tablet or pill (drug portion) that corresponds to tablets or pills retained in the accommodation. The space for
Petition 870190128972, of 12/06/2019, p. 29/44
26/31 receiving 22 is covered by means of a transparent cover element 23. A person can immediately consult with which tablets or pills the dosing station 2 needs to be filled. In the front perspective view of the dosing station 2, as shown in Figure 7, the housing 20 is shown partially transparent in order to make visible the internal mechanism of the dosing station 2. An axial individualization wheel is accommodated as shown in the housing 20 swivel 24 which is detachably connected to housing 20 and which is adapted during axial rotation to separate a single tablet or single pill which can subsequently be removed from housing 20 by means of a drop guide 25 arranged in the housing and it can be transferred to a through opening 13 of a drop tube 7 that connects to the drop guide 25. The individualization wheel 24 is provided here with a plurality of receiving spaces 26 for pills or tablets distributed at the edge periphery. The size of receiving spaces 26 can generally be adapted to the size of the pills or tablets to be retained in the supply. The individualization wheel 24 can be rotated axially by means of an electric motor 27 also accommodated in the housing 20. A sensor 28 is arranged in the drop guide 25 that can detect the moment when a pill or tablet for separation falls, and thus also if housing 20 has been emptied. The metering stations 2 are visible from an external side of the system 1 and accessible for possible refilling of metering stations 2. The housing 20 will generally be equipped with multiple LEDs (not shown) to allow the indication of the
Petition 870190128972, of 12/06/2019, p. 30/44
27/31 current situation of the dosing station 2, and particularly in the case where the dosing station 2 needs to be refilled or is malfunctioning.
[046] Figure 8 is a perspective view and Figure 9 is a side view of a collection container 17 for use in system 1, as shown in Figures 1 to 4. The collection container 17 here comprises a mounting element coupling 29 to collaborate with mounting element 16 of the second conveyor belt 15. In order to increase the stability of the collection container 17, the collection container 17 also comprises two gripping channels 30a, 30b for fixing or at least engaging around of the second conveyor belt 15. An upper side of the collection container 17 takes an open shape and is similar in shape to a funnel so that it can receive solid drug portions that fall from a drop tube 7. A underside the collection container 17 is provided with a pivoting closing element 31 provided with an operating latch by means of which the closing element 31 can be rotated to allow opening and thereby unloading of the container collection container 17. The collection container 17 will generally be provided with a tilting element (not shown), such as a compression spring, in order to propel the closing element 31 towards the position that closes the collection container 17, through from which the wrong opening of the collection container 17 can be prevented.
[047] Figures 10 and 11 show respectively a front perspective view and a rear perspective view of the packaging and unloading station 3, as applied in system 1, as shown in Figures
Petition 870190128972, of 12/06/2019, p. 31/44
28/31 to 4. The packaging station 3 comprises a sheet metal roll 32 which can be unwound by means of an electric motor 33, after which the unwound metal sheet 34 is directed by means of a plurality of rollers. direction 35 towards the collection containers 17 to be emptied. The direction of transport of the metal sheet 34 is indicated by arrows in both Figures 10 and 11. Before the metal sheet 34 is transported below a collection container 17 for emptying, the metal sheet 34 is provided with a longitudinal fold, through which a V-shaped fold 36 is created in which the drug portions can be received following the opening of the collection container 17. The metal sheet 34 can be provided with two transverse seals and a longitudinal seal for allow the complete sealing of the packaging 18. Two thermal bars 37 are applied in the formation of the longitudinal seal, of which only one thermal bar 37 is shown, and which press on each side of the two metal sheet parts to be attached to each other, through from which the sheet metal parts merge together and the longitudinal seal is formed. It is advantageous here that each thermal bar 37 engages metal sheet 34 by means of a stationary strip made from plastic, in particular Teflon, or a displaceable band 38 in order to prevent the adhesion of thermal bars 37 to the metal sheet. The transverse seals are also created by two vertical swiveling thermal bars 39 that collaborate with each other and press the sheet metal parts against each other when making a transverse seal. The packaging 18 can also optionally be provided with an identification. Successive packaging 18 remain mutually
Petition 870190128972, of 12/06/2019, p. 32/44
29/31 connected in the first instance and together they form a packaging strip.
[048] Figure 12 shows a drop tube 7 provided with two conjugated mounting elements 40a, 40b to collaborate with mounting elements 8 of the first two conveyor belts 6a, 6b, as applied to a system 1 according to any of the Figures 1 to 4. A particular attribute, however, of the drop tube 7 shown in Figure 12 is that the drop tube 7 is provided with an additional central guide element 41 to collaborate with a stationary guide 42 that can be attached to the structure of support 4 of system 1, through which additional stability is transmitted to the fall pipe 7 and both first conveyor belts 6a, 6b.
[049] Figure 13 shows a schematic and simplified example of the control of four dosing stations 43 (A, B, C, D) based on four prescriptions received for four patients (1, 2, 3, 4). For clarity purposes, in this simplified example, only four collection containers 44 are applied, where each collection container 44 is assigned to a specific patient and is thus used to collect a prescription for that patient. For convenience, drop tubes, which in fact couple dosing stations 43 with collection containers 44, are omitted. The collection containers 44 are attached to a conveyor belt and thus pass through the different dosing stations 43. In this example, patients require the following quantities of medication (A, B, C, D) (see the table).
Medication THE B Ç D of Patient
Petition 870190128972, of 12/06/2019, p. 33/44
30/31
1 0 1 1 2 2 2 2 0 1 3 0 1 0 1 4 1 2 3 4
[050] It appears from the table that patient 1, for example, does not require tablets of medicine A, a tablet of medicine B, a tablet of medicine C and two tablets of medicine D. Figure 13 shows seven different positions I a VII of the collection container train 44. In position I, the collection container 44 of patient 4 is positioned under the dosing station 43 filled with medicine A, through which the dosing station 43 will allow a tablet A to fall into the container collection container 44 for patient 4. In position II, collection container 44 for patient 4 is positioned under dosing station 43 filled with medication B, and collection container 44 for patient 3 is positioned under dosing station filled with medication A. In this position II two tablets B will be deposited in the collection container 44 of patient 4; as patient 3 does not require a tablet A, the associated dosing station 43 will remain inactive. In this way, the following conversion can be done for position-dependent dosages (see table).
THE B Ç D I 1 0 0 0 II 0 2 0 0 III 2 1 3 0 IV 0 2 0 4 V 0 1 0 1 SAW 0 0 1 1 VII 0 0 0 2
[051] The prescriptions of the different patients can be found here on a diagonal line (from the left
Petition 870190128972, of 12/06/2019, p. 34/44
31/31 top to bottom right). Dosing stations 43 are activated based on the analysis mentioned above. The dosing station 43 can be activated at the correct time based on the determination of a reference position of a first collection container 44, the transport speed of the
containers of collect 44 and the length of belt shipping company. [052] It will be apparent that the invention it is not
limited to the exemplary modalities shown and described here, but that numerous variations that will be self-evident to the person skilled in this field are possible within the scope of the attached claims.

权利要求:
Claims (22)
[1]
1. SYSTEM FOR PACKING MEASURED QUANTITIES OF SOLID DRUG PORTIONS, characterized by comprising:
a plurality of dosing stations (2) for delivering a metered amount of solid drug portions, a plurality of targeting ducts (7) coupled to a conveyor (6a, 6b, 15) for moving the targeting ducts (7 ) over the dosing stations (2), where each targeting duct (7) is adapted to receive portions of drug distributed from at least one of the dosing stations (2) when the targeting duct (7) is positioned in at least one dosing station (2) and to direct the received drug portions to an opening opening of the targeting duct (7), a plurality of collection containers (17) coupled to the transport means (6a, 6b , 15) so that each collection container (17) can be positioned in the passage opening of one of the targeting ducts (7) to receive portions of drug directed through the targeting duct (7), and at least one packaging and unloading (3) for tran sfer portions of drug collected by each collection container for a package and to close the package.
[2]
2. SYSTEM, according to claim 1, characterized in that the dosing stations (2) are arranged in a plurality of parallel columns, in which each column comprises a plurality of dosing stations, in which each directing duct (7) is adapted to receive
Petition 870190128972, of 12/06/2019, p. 36/44
2/6 portions of drug distributed from the dosing stations (2) of a column when the targeting duct (7) is positioned in the dosing station column (2).
[3]
3. SYSTEM according to claim 2, characterized in that the dosing stations (2) are arranged in a plurality of vertical columns and each directing duct (7) consists of a vertical drop tube.
[4]
4. SYSTEM, according to claim 3, characterized in that the width of a drop pipe (7) in the transport direction corresponds substantially to the width of a metering station (2).
[5]
A system according to any one of claims 1 to 4, characterized in that the means of transport (6a, 6b, 15) comprises a first endless conveyor (6a, 6b) and a second endless conveyor (15), the steering ducts (7) coupled to the first endless conveyor (6a, 6b) and the collection containers (17) being coupled to the second endless conveyor (15).
[6]
6. SYSTEM, according to claim 5, characterized in that the system comprises driving means (9, 10, 11) for driving the first endless conveyor (6a, 6b) and the second endless conveyor (15) with the same speed carriage.
[7]
7. A system according to either of claims 5 or 6, characterized in that the width of a collection container (17) in the direction of transport substantially corresponds to the width of a duct (7) in the direction of transport.
[8]
8. SYSTEM, according to any one of claims 5 to 7, characterized by the physical length
Petition 870190128972, of 12/06/2019, p. 37/44
3/6 of the second conveyor (15) is greater than the length of the first conveyor (6a, 6b), so that the number of collection containers (17) coupled to the second conveyor (15) is greater than the number of drop tubes (7) coupled to the first conveyor (6a, 6b).
[9]
SYSTEM, according to any one of claims 5 to 8, characterized in that each drop tube (7) is detachably coupled to the first conveyor (6a, 6b).
[10]
10. SYSTEM, according to any one of claims 5 to 9, characterized in that each collection container (17) is detachably coupled to the second conveyor (15).
[11]
11. SYSTEM, according to any one of the preceding claims, characterized in that the underside of each collection container (17) comprises a controllable closing element (31) to allow the removal of the collected drug portions from the collection container.
[12]
12. SYSTEM, according to claim 11, characterized in that the closing elements (31) are mechanically displaceable by the packaging and unloading station (3).
[13]
13. SYSTEM according to claim 8, characterized in that the system also comprises at least one special dosing station for dispensing less frequently applied drug portions, the special dosing station being positioned in relation to the second conveyor (15) so that the drug portions delivered by the special dosing station can be received directly in a collection container (17)
Petition 870190128972, of 12/06/2019, p. 38/44
4/6 positioned in the special dosing station.
[14]
14. SYSTEM according to any one of the preceding claims, characterized in that each dosing station (2) comprises a supply container (20) that receives a plurality of solid drug portions and a dosing device (24) that connects to the supply container, wherein the dosing device is adapted to separate a single portion of solid drug from the solid drug portions present in the supply container (20).
[15]
15. SYSTEM, according to claim 14, characterized in that the dosing device is movable in relation to the supply container between a loading state, in which a receiving space of the dosing device connects to a delivery opening of the storage container. filling and unloading state, in which the dosing device covers the delivery opening and is adapted to deliver the separate solid drug portion to a targeting duct positioned at an outlet of the dosing station.
[16]
16. SYSTEM, according to claim 15, characterized in that the dosing station (2) comprises an electric motor, in particular a stepper motor, for moving the dosing device in relation to the supply container (20), an measurement to measure the resistance produced by the electric motor and the dosing station comprises a station control to deliver a metered amount of solid drug portions on demand, where the station control is adapted to invert the electric motor, if the resistance detected fur
Petition 870190128972, of 12/06/2019, p. 39/44
5/6 measuring element exceeds a predefined value.
[17]
17. A system according to claim 15 or claim 16, characterized in that the metering device comprises a rotating individualization wheel (24) mounted on the supply container.
[18]
18. A system according to any one of claims 14 to 17, characterized in that the dosing device comprises a sensor (28) for detecting the moment when a solid drug portion is dispensed by the dosing station.
[19]
19. SYSTEM according to any one of the preceding claims, characterized in that the system comprises a control unit (19) for controlling the packaging and unloading station (3), the dosing stations (2), the means of transport (6a , 6b, 15), wherein the control unit is adapted to determine, based on a desired metered amount of drug portions for packaging, a metered amount of drug portions to be successively distributed over time to a plurality of stations of dosing through the drop tubes to the collection containers.
[20]
20. METHOD FOR DOSING SOLID DRUG PORTIONS, making use of a system, as defined in any one of claims 1 to 19, characterized by comprising:
A) receive a prescription with a desired amount of solid drug portions,
B) determine, based on the prescription, the quantity of solid drug portions to be distributed by at least one dosing station (2) to a selected collection container (17),
Petition 870190128972, of 12/06/2019, p. 40/44
6/6
C) move the targeting ducts (7) by the means of transport (6a, 6b) and cause the dosing stations (2) to distribute the determined quantity of drug portions to a targeting duct (7) which moves to the along the respective dosing stations (2) with the purpose of directing the solid drug portions distributed to the selected collection container (17),
D) having the collection container (17) moved by means of transport (15) to a packaging and unloading station (3), and
E) have the dosed quantity of solid drug portions delivered by the collection container (17) at the packaging and unloading station.
[21]
21. METHOD according to claim 20, characterized in that, during step A), a plurality of prescriptions are received, in which, during step B), each prescription is linked to a selected collection container (17).
[22]
22. METHOD according to either of claims 20 or 21, characterized in that drug portions collected by a collection container (17) during step E) are discarded if, during step C), insufficient solid drug portions have distributed in the selected collection container.

类似技术:

公开号 | 公开日 | 专利标题

BR112014005345B1|2020-06-02|SYSTEM FOR PACKING DOSED QUANTITIES OF SOLID DRUG PORTIONS; AND METHOD FOR DOSING SOLID DRUG PORTIONS

JP6093445B2|2017-03-08|Device for packing a dose of medicament and method for operating said device

KR102187435B1|2020-12-08|A storage and dosing station for storage and dispensing dosed quantities of solid drug portions

BR112015004065B1|2020-12-01|apparatus for packaging metered quantities of solid drug portions comprising mobile collection containers and auxiliary dosing station

BR112015003882B1|2020-12-22|apparatus for packaging dosed quantities of solid portions of medicine

同族专利:

公开号 | 公开日

ES2573782T3|2016-06-10|

BR112014005345A2|2019-03-19|

JP2014526289A|2014-10-06|

DK2753545T3|2016-06-06|

EP2753545A1|2014-07-16|

KR20140072870A|2014-06-13|

CA2846185A1|2013-03-14|

US10589883B2|2020-03-17|

US20200165016A1|2020-05-28|

KR20190119655A|2019-10-22|

JP6047784B2|2016-12-21|

CN103987625B|2016-02-17|

EP2753545B1|2016-03-30|

AU2012306452B2|2016-04-21|

CN103987625A|2014-08-13|

US20140298754A1|2014-10-09|

WO2013034504A1|2013-03-14|

NL2007384C2|2013-03-12|

CA2846185C|2019-04-30|

US11254454B2|2022-02-22|

AU2012306452A1|2014-03-13|

KR102140447B1|2020-08-04|

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法律状态:
2017-07-11| B25D| Requested change of name of applicant approved|Owner name: BD SWITZERLAND SARL (CH) |

2017-07-25| B25G| Requested change of headquarter approved|Owner name: BD SWITZERLAND SARL (CH) |

2019-02-19| B25L| Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled|Owner name: BD SWITZERLAND SARL (CH) Free format text: ANULADA A PUBLICACAO CODIGO 25.7 NA RPI NO 2429 DE 25/07/2017 POR TER SIDO INDEVIDA. |

2019-03-06| B25L| Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled|Owner name: CAREFUSION SWITZERLAND 317 SARL (CH) Free format text: ANULADA A PUBLICACAO CODIGO 25.4 NA RPI NO 2427 DE 11/07/2017 POR TER SIDO INDEVIDA. |

2019-04-09| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

2019-09-10| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

2020-03-24| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2020-06-02| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2012, OBSERVADAS AS CONDICOES LEGAIS. |

2020-07-07| B25D| Requested change of name of applicant approved|Owner name: BD SWITZERLAND SARL (CH) |

2020-07-28| B25G| Requested change of headquarter approved|Owner name: BD SWITZERLAND SARL (CH) |

优先权:

申请号 | 申请日 | 专利标题

NL2007384|2011-09-09|

NL2007384A|NL2007384C2|2011-09-09|2011-09-09|SYSTEM AND METHOD FOR PACKING DOSED QUANTITIES OF SOLID MEDICINES|

PCT/EP2012/067013|WO2013034504A1|2011-09-09|2012-08-31|System and method for packaging dosed quantities of solid drug portions|

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