• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Apparatus and Method for Affecting Subcutaneous Adipose Tissue. Exemplary modalities of methods and apparatus are provided to damage and / or remove subcutaneous adipose tissue, leaving the overlying skin dermal layer substantially intact. One or more hollow needles can be provided that include an arrangement within the lumen configured to retain or damage the parts of adipose tissue that enter the lumen. The properties of the needle can be selected in such a way that the needle can be inserted into the skin and passed through the dermal layer, allowing the adipose tissue to enter the distal part of the lumen as it is further advanced, and then leave the dermis intact when removed. Such an exemplary apparatus may include a plurality of such needles, a shuttle arrangement for advancing and withdrawing one or more needles mechanically and / or a vibration arrangement.
    公开号:BR112014001248B1
    申请号:R112014001248-2
    申请日:2012-07-20
    公开日:2020-12-08
    发明作者:William G. Austen Jr
    申请人:The General Hospital Corporation；
    IPC主号:
    专利说明:

    Descriptive Report REMISSIVE REFERENCE TO RELATED ORDERS
    [0001] This application refers to and claims the priority of United States Provisional Patent Application Serial No. 61 / 510.242, filed on July 21, 2011, the disclosure of which is incorporated into this document in its entirety by reference. TECHNICAL FIELD OF THE INVENTION
    [0002] The present invention relates to methods and apparatus for removing or damaging small portions of adipose tissue, for example, subcutaneous fat, while decreasing or preventing significant damage to the overlying tissue, for example, the dermis and the epidermis. BACKGROUND OF THE INVENTION
    [0003] Procedures and devices for removing adipose tissue, for example, for aesthetic purposes, are common and represent an important market in the sector of aesthetic procedures. Conventional procedures and devices for removing fat, for example, for liposuction, can be harmful to the surrounding tissue and generally bring with it several risks, such as excessive bleeding, etc. There are relatively few procedures for removing small amounts of adipose tissue, for example, subcutaneous fat, for aesthetic purposes, and these procedures generally require an experienced professional for effective removal, in addition to being very time consuming and subject to complications.
    [0004] Therefore, there is a need to propose simpler and safer methods and devices for the removal of subcutaneous adipose tissue, which solve and / or reduce the limitations described above. SUMMARY OF THE INVENTION
    [0005] The present disclosure describes exemplary embodiments of simple, economical and safe methods and devices to affect adipose tissue, for example, subcutaneous fat, while decreasing or preventing significant damage to overlying tissue, for example, to the dermis and epidermis. These methods and devices make it possible to remove small portions of subcutaneous adipose tissue, which can be optionally implanted in other parts of the body or used to harvest stem cells present in them. Also described are methods and devices for locally tearing small regions of adipose tissue, which can then be reabsorbed by the body.
    [0006] It is possible to produce an exemplary apparatus according to the present invention that includes a hollow needle with at least one protuberance on its inner wall. The hollow needle is configured to be inserted into a biological tissue, such as the skin, in such a way that it penetrates the upper tissue layers. The size and geometry of the needle are configured in such a way that the tissues under the surface that are softer or less resilient, for example, subcutaneous fat, enter the hollow core of the needle when the distal end of it advances into the fat. The bulge is configured to facilitate the retention of a portion of fat when the needle is removed from the tissue.
    [0007] In another exemplary embodiment of the present invention, several of these hollow needles with internal protuberances are attached to a substrate. The substrate and the needles can be designed to control and / or limit the depth of penetration of the needles into the fabric when the substrate is positioned on the fabric surface. For example, the length of the distal end of the needles, which protrudes from the lower surface of the substrate, can be selected to match the depth within the adipose tissue under the skin surface.
    [0008] In other exemplary embodiments of the present invention, the hollow needle includes a pivoting flap or one or more splinters within the channel in order to facilitate detaching and removing portions of fat by the needle.
    [0009] In yet other exemplary embodiments of the present invention, the hollow needle includes a cutting structure within the channel to facilitate mechanical damage and / or the tearing of portions of fat by means of the needle.
    [00010] In yet another exemplary embodiment of the present invention, the exemplary apparatus further includes a vacuum source in communication with the proximal end of the needles, which facilitates the separation and / or removal of portions of fat from the surrounding tissue when the needle is inserted and removed.
    [00011] In yet another exemplary embodiment of the present invention, the exemplary apparatus includes a structure of reciprocal movement fixed on one or more needles. The reciprocal movement structure includes a motor or other actuator configured to repeatedly advance and withdraw the needles from the fabric. The structure of reciprocal movement can be arranged in a housing that facilitates the manipulation of the apparatus, for example, the positioning of the apparatus on the fabric under treatment and / or crossing the apparatus on the tissue. As an option, the housing is configured to stretch or otherwise stabilize the tissue proximal to the inserted needles in order to decrease the deformation of the tissue and / or improve the accuracy of the positioning of the needles in the tissue. The structure of reciprocal movement can also include a translational controller configured to translate the needles over the tissue in at least one direction, and, optionally, in two orthogonal directions, in order to facilitate the removal or collection of fat from regions larger than a tissue donor site without moving the entire device over the tissue surface.
    [00012] In yet another exemplary embodiment of the present invention, the exemplary apparatus includes a vibrational structure mechanically coupled to one or more needles. The vibrational structure facilitates the improved removal and / or tearing of adipose tissue by means of needles.
    [00013] These and other objectives, characteristics and advantages of the present disclosure will be best seen by reading the detailed description of exemplary embodiments of the present invention below when in conjunction with the accompanying drawings and Claims. BRIEF DESCRIPTION OF THE DRAWINGS
    [00014] Other objectives, characteristics and advantages of the present invention will be apparent from reading the detailed description together with the attached figures that illustrate illustrative embodiments, results and / or characteristics of the exemplary embodiments of the present invention, among which:
    [00015] FIG. IA is a cross-sectional side view of an exemplary apparatus for removing adipose tissue under the surface according to exemplary embodiments of the present invention;
    [00016] FIG. 1B is a cross-sectional side view of the exemplary apparatus illustrated in FIG. IA according to a first embodiment of the present invention; FIG. 1C is a cross-sectional side view of the exemplary apparatus illustrated in FIG. IA according to a second embodiment of the present invention;
    [00017] FIGS. 2A to 2C are schematic side views of the exemplary apparatus illustrated in FIG. IA being used to remove adipose tissue under the surface according to exemplary embodiments of the present invention;
    [00018] FIG. 3A is a cross-sectional side view of a second exemplary apparatus for removing adipose tissue under the surface according to other exemplary embodiments of the present invention;
    [00019] FIG. 3B is a schematic front view of a first exemplary embodiment of the exemplary apparatus illustrated in FIG. 3A;
    [00020] FIG. 3C is a schematic front view of a second exemplary embodiment of the exemplary apparatus illustrated in FIG. 3A;
    [00021] FIG. 4 is a cross-sectional side view of a third exemplary apparatus for removing adipose tissue under the surface in accordance with yet other exemplary embodiments of the present invention;
    [00022] FIG. 5A is a cross-sectional side view of a fourth exemplary apparatus for removing adipose tissue under the surface in accordance with yet other exemplary embodiments of the present invention;
    [00023] FIGS. 5B and SC are schematic side views of the exemplary apparatus illustrated in FIG. 5A illustrating the removal of adipose tissue under the surface according to exemplary embodiments of the present invention;
    [00024] FIG. 6A is an end view of a first exemplary embodiment of the exemplary apparatus illustrated in FIG. 5A;
    [00025]. FIG. 6B is an end view of a second exemplary embodiment of the exemplary apparatus illustrated in FIG. 5A;
    [00026] FIG. 7 is a cross-sectional side view of a fifth exemplary apparatus for removing fatty tissue under the surface according to yet other exemplary embodiments of the present invention;
    [00027] FIG. 8A is a cross-sectional side view of an exemplary apparatus for damaging or breaking an adipose tissue under the surface according to yet other exemplary embodiments of the present invention;
    [00028] FIG. 8B is an end view of a first exemplary variant of the exemplary apparatus illustrated in FIG. 8A; and
    [00029] FIG. 8C is an end view of a second exemplary variant of the exemplary apparatus illustrated in FIG. 8A.
    [00030] Throughout the drawings, the same numbers and reference characters, unless otherwise stated, are used to indicate characteristics, elements, components or equal parts of the illustrated embodiments. In addition, although the present invention is now described in detail with reference to the figures, this is done with reference to the illustrative embodiments and, therefore, the present invention is not limited to the specific embodiments illustrated in the figures and the appended Claims. DETAILED DESCRIPTION
    [00031] Exemplary embodiments of the present invention propose methods and apparatus for locally removing or damaging or tearing soft tissue, for example subcutaneous fat, while decreasing or preventing significant damage to overlying tissue, for example, the dermis and the epidermis. Exemplary embodiments of the present invention can therefore facilitate removal, collection or tearing of tissue under the surface while preventing and / or minimizing adverse effects such as scarring, bleeding, the risk of infections etc.
    [00032] FIG. 1A illustrates a cross-sectional view of an exemplary apparatus 100 for removing adipose tissue. The exemplary apparatus 100 includes a hollow needle 120 with a central channel which further includes at least one protuberance 130 along at least part of its internal surface, for example, extending to a certain part of the central channel. An open distal end 110 of needle 120 may be provided with a sharp and / or angled edge to facilitate insertion of needle 120 into the skin or other tissue. For example, the distal end 110 of needle 120 can be in cuneiform shape, which can be imparted to it, for example, by grinding the end of needle 120 at an acute angle to the longitudinal axis. The angle of the distal end can be, for example, about 45 °, or between about 30 ° and about 50 °, which can provide the selective tissue penetration characteristics described in this document. These exemplary angles can be used in any of the exemplary embodiments described in this document.
    [00033] The protuberance 130 can be arranged along the inner surface of the shorter side of the tapered or tapered end 110 of the needle 120. A handle 140 and / or other gripping structure can be arranged in the proximal region of the needle 120 to facilitate on the spot to hold and handle needle 120.
    [00034] FIG. 1B illustrates a front view of the exemplary apparatus 110. The protrusion 130 can be configured to block and / or obstruct a part of the hollow center of the needle 120. The exemplary protrusion 130 shown in FIG. 1B includes a substantially straight edge towards the center of the hollow core of the needle 120. Another exemplary protuberance 130 is illustrated in FIG. 1C, which includes a curved edge oriented towards the center of the hollow core of the needle 120. It is also possible to give other shapes to the protuberance 130 in other exemplary embodiments of the present invention. Several of these protrusions 130 can also be included in needle 120. The cross-sectional shape of the exemplary needle 120 illustrated in FIG. 1B is substantially round. Needles 120 with other cross shapes can also be used, for example, needles 120 can have oval, square, triangular cross sections, etc.
    [00035] For example, protuberance 130 may block less than about 50% of the transverse area of the hollow center, or, optionally, less than about 30% of that area. The protrusion 130 can block more than about 10% of the transverse area or more than about 20% of that area. The size and shape of the protrusion 130 is configured to facilitate the retention of adipose tissue in the hollow core of the needle 120, as described in this document.
    [00036] The exemplary apparatus 100 is inserted into a dermal tissue such that the distal end 110 penetrates at least partly into the subcutaneous fat layer 210 below the dermis 220, as shown in FIG. 2. After this introduction, a portion 230 of adipose tissue enters the hollow core of needle 120. Then, the exemplary apparatus 100 is removed from within the dermal tissue. As shown in FIG. 2B, the portion 230 of adipose tissue is also removed from within the adipose layer 210 and remains within the hollow needle 210. The protuberance 130 facilitates the removal of the portion 230 of adipose tissue from within the adipose layer 210. After removing the example apparatus 100 from within the dermal tissue, the dermal layer collapses around the route of introduction, as shown in FIG. 2C, and subsequently heals, while the portion 230 of fat from the adipose layer 210 has been removed. Therefore, this exemplary method and apparatus facilitates the removal of subcutaneous fat 230 with a relatively small disturbance to the overlying dermis 220.
    [00037] Needle diameter 120 is selected to facilitate introduction through dermal layer 220 without removing a significant amount of dermal tissue, as well as to facilitate the separation and removal of portion 230 of adipose tissue, as described in this document. For example, needle 120 may be the size of a conventional 16 gauge needle, or between 14 gauge and 19 gauge. These needle diameters can provide the selective tissue penetration properties described in this document when apparatus 100 is inserted into the needle. skin. The diameter of the central channel of the needle 120 can be, for example, about 1 mm or about 1.25 mm. Such exemplary needle sizes can be used in any of the exemplary embodiments described in this document. Larger or smaller needle sizes can also be used in other embodiments of the present invention if they provide the selective tissue penetration properties described in this document, for example, if the methods and apparatus described in this document are used in fabrics other than the skin.
    [00038] In exemplary embodiments of the present invention, the slanted or tapered distal end 110 of needle 230, as described herein, may deviate from resilient dermal tissue 220 or lay it aside as needle 120 is inserted. As the needle 120 penetrates the fatty tissue 210, the softer portion of fatty tissue 230 is more easily separated from the surrounding fatty layer 210 and enters the hollow core of the needle 120. The protuberance 130 anchors the portion 230 of tissue adipose tissue inside the needle 120 and facilitates its separation and removal of the surrounding adipose tissue 210 when the exemplary apparatus 100 is removed from the dermal tissue. The exemplary apparatus 100 can be inserted and removed several times to remove other portions 230 of adipose tissue.
    [00039] Another exemplary apparatus 300 for removing subcutaneous fat according to the present invention is illustrated in FIG. 3A. Such an exemplary apparatus 300 includes several needles 120 attached to a substrate 330. The substrate 330 can have a substantially flat bottom surface from which the needles 120 protrude, or that surface can be curved or have some other type of contour, for example , to more closely match the contour of the dermal tissue surface being treated.
    [00040] FIG. 3B illustrates a front view of the exemplary apparatus 300. Needles 120 can be arranged in a square or rectangular pattern, as shown in FIG. 3B. Alternatively, the rows of needles 120 can be moved or wobbled to form a triangular pattern, as shown in FIG. 3C. Other exemplary structures of needles 120 can be used, such as a spatially random distribution of needles 120 over substrate 330. The number of needles 120 and the spacing between adjacent needles 120 can be selected based on the specific tissue being treated, the amount of fat that will be removed etc.
    [00041] The distance from the protrusion of the needles 120 to the lower surface of the substrate 330 can also be selected based on the local depth of the subcutaneous adipose layer 210 and the depth from which the adipose tissue will be removed. For example, the exemplary apparatus 300 may include a structure configured to adjust the distance from the protrusion of needles 120. That structure may include, for example, a plate, or the like, attached to substrate 330 in such a way that needles 120 to go through. The distance between the plate and the substrate 330 can be adjustable to vary the distance by which the needles 120 project from the bottom surface of the plate. It is also possible to use other exemplary structures that facilitate the adjustment of the effective length of the needles 120 that project from the base of the apparatus 300. The location of one or more protuberances 130 within the needles 120 can also be selected in order to control the size or the height of the tissue samples 230 that will be retained and removed by the needles 130 when they are inserted and removed from the tissue, as described in this document.
    [00042] The exemplary apparatus 300 can be inserted into the dermal tissue and subsequently removed in such a way that the needles 120 penetrate the adipose layer 210 and remove portions of the tissue sample 230 from the adipose tissue from within the adipose layer 210, as described in this document and illustrated in FIGs. from 2A to 2C in the case of a single needle 210. The exemplary apparatus 300 facilitates the removal or collection of a greater amount of adipose tissue with a single introduction and removal of the exemplary apparatus 300 from within the dermal tissue.
    [00043] FIG. 4 illustrates yet another exemplary apparatus 400 according to the present invention, which includes one or more needles 120, as described in this document, which can be attached to a reciprocating movement structure 420 arranged within a housing 430. The housing 430 also may include a handle 410. The reciprocal movement structure 420 can be configured to move the needles 120 back and forth along a direction that can be substantially parallel to the axis of the needles 120. For example, the reciprocal movement structure 420 it can be powered by a motor or something similar and / or controlled by a switch capable of turning it on and off and capable of still controlling the frequency of the reciprocal movement and / or the distance from the protrusion of the needles 120 under the lower surface of the housing 430. This exemplary apparatus 400 can pass through a region of the skin that will be treated so that one or more needles 120 are inserted and removed repeatedly d the tissue, thereby removing a portion of adipose tissue at each removal as described in this document. The penetration depth of the needles 120 can be determined by the configuration of the reciprocal movement structure 420.
    [00044] In another exemplary embodiment according to the present invention, the reciprocal movement structure 420 further includes a translational mechanism configured to translate one or more needles 120 on the fabric surface in one or two orthogonal directions. For example, the reciprocal movement structure 420 can be configured to transfer said one or more needles 120 over an area of the tissue while the exemplary apparatus 400 remains stationary in relation to the surface of the tissue at a donor or treatment site. In an exemplary embodiment of the present invention, the reciprocal movement structure 420 is configured to translate the one or more needles 120 along a single direction to collect adipose tissue along one or more rows. As an option, the exemplary apparatus 400 moves over the tissue surface after forming these rows, for example, in a direction that is not parallel to the rows, in order to remove or collect adipose tissue from a larger area of the donor tissue site.
    [00045] In other exemplary embodiments of the present invention, any of the exemplary apparatus described in this document can be configured to remove or collect adipose tissue from various locations in any of several spatial distributions, with each location corresponding to a single introduction and removal of a single needle 120. For example, adipose tissue can be removed or collected from various locations configured as one or more rows, a regular two-dimensional pattern, a random distribution or the like. These exemplary spatial patterns or distributions of fat collection or removal sites can be generated based, for example, on the configuration of said one or more needles 120 provided, on the properties of the reciprocal movement structure 420 and / or on the translation rate of the exemplary apparatus 400 on the fabric surface.
    [00046] In yet other exemplary embodiments in accordance with the present invention, housing 430 can be configured to stretch the skin or other fabric when the exemplary apparatus 400 is arranged on the fabric to be treated. Such stretching facilitates the mechanical stabilization of the fabric, for example, to decrease or prevent deformation of the fabric 350 as the needles 120 are inserted and removed from it. This stretching of the tissue also decreases the effective size of the torn region of the upper tissue layers formed by the exemplary apparatus 400, as it allows the tissue to relax after treatment. Alternatively, the surface of the fabric to be treated can be stretched or stabilized using other techniques before and / or during treatment of the region according to any of the exemplary embodiments described in this document.
    [00047] For example, a vacuum or suction source, for example, a pump or reservoir containing fluid under low pressure, can be included in communication with the needle channel 120, for example, through a conduit in communication with the proximal end of needles 120, in any of the exemplary embodiments described in this document. This low pressure, that is, pressure below atmospheric or ambient pressure, in the central channel facilitates the removal of portions 230 of adipose tissue when the distal end of needles 120 is within the subcutaneous fat layer 210. For example, the exemplary devices described in this document can be configured to produce said vacuum when the distal end of the needles 120 is inserted at least in part into the fat layer 210 and that vacuum can be applied as the needles 120 are removed from the fat layer 210. The vacuum resistance can be selected in order to facilitate the removal of portions 230 of adipose tissue in the distal part of needles 120 without causing significant damage to the tissue around the inserted needles 120.
    [00048] In another exemplary embodiment of the present invention, an apparatus 500 adapted to remove adipose tissue is proposed as illustrated in 3. 5A. The exemplary apparatus 500 includes a hollow needle 120 with a central channel, the size and shape of the needle 120 and its distal end 110 being the same as those described above with reference to the apparatus 100 illustrated in FIG. IA. The apparatus 500 includes at least one pivoting flap 510 within the needle channel 120. The flap 510 is arranged on the distal part of the needle 120, for example, and configured in such a way that part of it pivotally connects to the inner wall of the needle. needle 120 at a 510 pivot point.
    [00049] A stop structure 530 is arranged elsewhere on the inner wall of the needle 120 to limit or prevent the displacement of the flap beyond a certain limit in a specific direction. For example, the stop structure 530 can be arranged opposite the inner wall of the needle from pivot point 520, as shown in FIG. 5A. In this exemplary configuration, the flap 510 is free and configured to pivot upwards towards the proximal end of the needle 120 but be prevented from pivoting towards the distal end 110 of the needle 120 in addition to the stop structure 530. In another exemplary embodiment, the stop structure stop 530 is arranged at a location higher or lower than pivot point 520 (i.e., closer or further from the distal end 110 of needle 120). The stop structure 530 can also be arranged on a lateral side of the inner needle wall, instead of diametrically in front of pivot point 520 as shown in FIG. 5A. The stop structure 530 can be produced, for example, by indenting an outer region of the needle wall such that that region of the wall protrudes or penetrates the needle channel 120. Alternatively, a small object can be attached to the wall needle 120 to form the stop structure. Other techniques and configurations can also be used to form the 530 stop structure.
    [00050] The exemplary apparatus 500 can be used to remove or collect portions of adipose tissue in a manner similar to that described with reference to the exemplary apparatus 100 and illustrated in FIGS 2A to 2C. For example, the distal end 110 of the apparatus 500 can be advanced through the dermis 220 and into the subcutaneous adipose layer 210, as shown in FIG. 5B. The exemplary apparatus 500 can be configured such that the distal end penetrates the dermis 220 with little or no portion of the dermal tissue entering the needle channel 120. As the distal end 110 penetrates the fat layer 210, a portion 230 of softer adipose tissue enters the needle channel 120. The portion 230 advances into the channel, propelling the flap 210 up and closer to the inner wall of the needle 120, as shown in FIG. 5B.
    [00051] When the exemplary apparatus 500 is removed from the skin, the adipose portion 230 is pulled slightly down into the channel, thereby pushing or dragging the flap 510 along with it towards the distal end 110 of needle 120. For example, the edge the flap 510 can 'capture' or penetrate the edge of the fatty portion 230. As the flap 510 descends, it cuts partly or completely the fatty portion 230 of the rest of the subcutaneous fat underneath it, thereby retaining the fatty portion 230 within device 500 as it is removed from the skin.
    [00052] The flap 510 can be substantially round or in a lunar shape, for example, in such a way that it substantially blocks or obstructs the entire channel when descending to the stop structure 530. For example, an exemplary flap 510 is illustrated in FIG. 6A in the elevated position (i.e., pivoted upward, away from the distal end 110 of needle 120). In this figure, the view of the flap 510 is from the distal end 110 of the needle 120 along its longitudinal axis. In this exemplary configuration, the thin round flap is curved instead of flat, in such a way that it better adapts to the shape of the inner wall of the needle 120 when pivoted upwards as shown in FIG. 6A. Said curved flap 510 facilitates the advancement of an adipose tissue 230 within the exemplary apparatus 500 by decreasing or minimizing the obstruction of the channel when pivoted upward.
    [00053] In another exemplary embodiment, the flap 510 is substantially rectangular or in another shape that does not completely obstruct the channel when pivoting to the lowered position, that is, resting on the stop structure 530, as shown in a view of one of the needle ends 120 in FIG. 6B. The shape of this exemplary flap can also be curved, similar to flap 510 illustrated in FIG. 6A, to decrease the obstruction of the channel when the flap 510 pivots to the elevated position.
    [00054] Any of the characteristics of the exemplary apparatus 500 can be used in conjunction with the other exemplary embodiments described in this document. For example, one or more needles 120 with a pivoting tab 510 and stop structure 530 can be attached to a substrate 330, for example, as shown in FIGS. from 3A to 3C. One or more of said needles 120 with pivoting tab 510 can also be coupled to a reciprocating movement structure 420 as shown in FIG. 4.
    [00055] In yet another exemplary embodiment of the present invention, an apparatus 700 is proposed with one or more barbs 710 disposed on the inner wall of the hollow needle 120. Each bark 710 can be tilted upwards, for example, by tilting away from the distal end 110 of needle 120, as shown in FIG. 7. This exemplary configuration facilitates the advancement of adipose tissue within the channel as the apparatus 700 advances within the adipose layer 210, in addition to promoting the retention of an adipose portion 230 within the channel as the apparatus 700 is removed from the skin. These barbs can be formed, for example, by deforming the outer wall of the needle 120 inward at a certain angle in one or more locations, by attaching preformed barbs 710 to the inner wall of the needle 120 or by other techniques. The characteristics of the exemplary apparatus 700 can be used in conjunction with the other exemplary embodiments described in this document. For example, several needles 120 with one or more barbs 710 can be attached to a substrate 330, for example, as shown in FIGS. from 3A to 3C. One or more of these needles 120 can also be coupled to a reciprocating movement structure 420 as shown in FIG. 4.
    [00056] In still other exemplary embodiments of the present invention, an apparatus 800 with a cutting structure 810 disposed in a distal part of the hollow needle channel 120, as shown in FIG. A. The apparatus 800 facilitates the mechanical tearing of the adipose tissue 210 without removing a significant amount of it from the surrounding tissue. As with the other exemplary embodiments described in this document, the exemplary apparatus 800 affects the tissue in the fat layer 210 without significantly affecting or damaging the overlying dermal layer 220 when the apparatus 800 is removed from the skin. For example, performing a mechanical tearing in the fatty layer 210 can lead to cell damage and / or death. The damaged or dead cells are then reabsorbed by the body over time, decreasing the amount of fat present in the treated area.
    [00057] The cutting structure 810 can include, for example, one or more thin handles, thin blades or the like extending through a certain part of the needle channel 120. FIGs. 8B and 8C illustrate end views of two exemplary cutting structures 810. Cutting structure 810 in FIGS. 8B and 8C includes several blades or thin threads connected to the inner wall of the needle 120 and crossing part of the channel. Other configurations of the cutting structure 810 can be produced in other embodiments of the invention.
    [00058] The exemplary apparatus 800 is inserted into the skin tissue and then removed as described in this document, for example, with reference to other exemplary embodiments of the present invention. This exemplary introduction and removal of the exemplary apparatus 800 causes a portion of the fat layer 210 to enter the needle channel 120, with the overlying dermal layer 220 remaining substantially unchanged after removing the entire apparatus 800. The adipose tissue entering the channel is damaged by cutting structure 810 during insertion and removal procedures. The exemplary apparatus is partially removed from the skin and then advanced again several times before completely removed from the skin. For example, the example apparatus 800 can be removed until the distal end 110 is proximal to the lower part of the dermal layer 220, then further advanced further into the fat layer 210. These repeated cycles generate a greater degree of local damage to the adipose tissue. . Little or no fat remains inside the channel when the device 800 is removed from the skin. However, damaged fat cells die and are reabsorbed by the body over time.
    [00059] The characteristics of the exemplary apparatus 800 can be used in conjunction with the other exemplary embodiments described in this document. For example, several needles 120 with a cutting frame 810 can be attached to a substrate 330, for example, as shown in FIGS. from 3A to 3C. One or more of these needles 120 can also be coupled to a reciprocating movement structure 420 as shown in FIG. 4 to generate damage in a wider region of the fat layer 210.
    [00060] The exemplary apparatus 800 may include several needles 120 with different types of fat tearing structures as described in this document. For example, different needles 120 may include a protrusion 130, a pivoting flap 510 or a cutting structure 810. In another exemplary embodiment, several needles 120 containing different types of said fat-stripping structures 130, 510 and 810 can be mechanically coupled to a reciprocal movement structure 420 as described in this document. The different needles 120 in said multi-needle devices can, as an option, have different lengths, which can facilitate the collection or damage of fat at different depths within the adipose layer 210.
    [00061] In other exemplary embodiments of the present invention, a vibrational structure can be mechanically coupled to any apparatus described in this document. The vibration induction in needles 120 can facilitate the detachment of adipose portions 230 from the surrounding tissue and / or can generate greater mechanical damage by a cutting structure included in needle 120.
    [00062] The exemplary methods and devices described in this document can be used for various purposes, for example, to remove small portions of adipose tissue for aesthetic purposes, to collect stem cells present in regions of the subcutaneous adipose layer, to collect adipose tissue for implant in other regions of the body for aesthetic purposes and / or to generate mechanical damage to fat cells in order to promote cell death and reabsorption of the damaged fat by the body.
    [00063] The provisions above merely illustrate the principles of the present invention. Various modifications and changes to the described embodiments will be apparent to those skilled in the art based on the teachings in this document. Thus, it will be realized that those skilled in the art may come up with various techniques that, although not explicitly described in this document, carry with them the principles of the invention and, therefore, are included within the scope and essence of the present invention. All patents and publications cited in this document are hereby incorporated in full by reference.
    权利要求:
    Claims (15)
    [0001]
    1. Apparatus for affecting subcutaneous adipose tissue, characterized by the fact that it comprises: a plurality of needle arrays (120), wherein each needle of the plurality of needle arrays comprises a central lumen; and at least one projection (130) provided along at least a portion of an inner wall of each needle of the plurality of needle arrays and proximal to a distal end of each needle of the plurality of needle arrays, wherein the shape of the The cross section of each needle of the plurality of needle arrays is substantially round, and wherein the at least one protrusion (130) is structured to contact a portion of the subcutaneous adipose tissue when each needle of the plurality of needle arrays is inserted into the tissue of the skin, so that at least a distal portion is located in the subcutaneous adipose tissue.
    [0002]
    Apparatus according to claim 1, characterized in that the distal end (110) of each needle of the plurality of needle arrangements is configured to be inserted into the skin tissue, pass through a dermal layer thereof and prevent a significant portion of the dermal tissue to enter the central lumen.
    [0003]
    Apparatus according to claim 2, characterized in that the distal end (110) of each needle of the plurality of needle arrangements is provided as an angled tip and in which an angle of the tip is between about 30 degrees and about 50 degrees.
    [0004]
    Apparatus according to claim 2, characterized in that the diameter of the central lumen of each needle of the plurality of needle arrangements is about 1 mm.
    [0005]
    Apparatus according to claim 2, characterized by the fact that a size of each needle of the plurality of needle arrangements is between gauge 14 and gauge 19.
    [0006]
    Apparatus according to claim 1, characterized in that it further comprises an alternative arrangement (420) configured to repeatedly insert and remove each needle from the plurality of needle arrangements of a skin tissue.
    [0007]
    7. Apparatus according to claim 6, characterized by the fact that the alternative arrangement (420) comprises an actuator and a control arrangement.
    [0008]
    Apparatus according to any one of claims 1 to 7, characterized in that the at least one protrusion is configured to retain at least one sample of the subcutaneous adipose tissue within the central lumen when each needle of the plurality of needle arrangements is removal of skin tissue.
    [0009]
    Apparatus according to claim 8, characterized in that the at least one protrusion occludes less than about 50% of the cross-sectional area of the central lumen.
    [0010]
    Apparatus according to claim 8, characterized in that the plurality of needle arrangements is mechanically coupled to a substrate (330).
    [0011]
    Apparatus according to claim 8, characterized by the fact that the at least one projection comprises a flap (510) hingedly attached to the interior wall portion.
    [0012]
    Apparatus according to claim 8, characterized in that the at least one projection comprises an angled rod (710) directed to the proximal end of the needle arrangement.
    [0013]
    Apparatus according to claim 12, characterized by the fact that the plurality of needle arrangements is mechanically coupled to a substrate.
    [0014]
    Apparatus according to any one of claims 1 to 7, characterized in that the at least one protrusion is configured to generate mechanical damage to the subcutaneous adipose tissue portion.
    [0015]
    Apparatus according to claim 14, characterized by the fact that the plurality of needle arrangements is mechanically coupled to a substrate.
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    同族专利:
    公开号 | 公开日
    WO2013013196A1|2013-01-24|
    CA2846229C|2019-08-27|
    EP2734249A4|2015-03-11|
    US20140277055A1|2014-09-18|
    HUE042454T2|2019-07-29|
    ES2693162T3|2018-12-07|
    IL230573D0|2014-03-31|
    CA2846229A1|2013-01-24|
    AU2012283861A2|2014-03-13|
    EP3427768A1|2019-01-16|
    AU2012283861B2|2016-11-24|
    BR112014001248A2|2017-02-21|
    EP2734249A1|2014-05-28|
    DK2734249T3|2018-12-10|
    PT2734249T|2018-11-13|
    US20180193054A1|2018-07-12|
    AU2012283861A1|2014-03-13|
    ES2833525T3|2021-06-15|
    EP2734249B1|2018-09-05|
    AU2017200903B2|2018-11-08|
    EP3427768B1|2020-10-14|
    AU2017200903A1|2017-03-02|
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    法律状态:
    2018-12-11| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-10-08| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-09-01| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-12-08| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/07/2012, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201161510242P| true| 2011-07-21|2011-07-21|
    US61/510,242|2011-07-21|
    PCT/US2012/047708|WO2013013196A1|2011-07-21|2012-07-20|Method and apparatus for damage and removal of fat|
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