• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    THROMBECTOMY DEVICE. The invention relates to a thrombectomy device, with a stent structure (1), essentially cylindrical, which presents a variety of meshes (3,4), as well as two connectors (5.5?), Arranged in different meshes (3) at the proximal end of the stent structure (1), presenting a conductive wire (2), which has a coupling element (11), to which the connectors (5.5?) are attached, as well as a slot (7), which extends in a spiral form on the lateral face (8) of the stent structure (1), and with a tensioning loop (9) that covers the slit (7) at the proximal end.
    公开号:BR112013029184B1
    申请号:R112013029184-2
    申请日:2012-05-14
    公开日:2020-12-01
    发明作者:Hermann Monstadt；Ralf Hannes；Jörg Ascherfeld
    申请人:Phenox Gmbh；
    IPC主号:
    专利说明:

    [0001] The present invention relates to a thrombectomy device with an essentially cylindrical stent structure, featuring a variety of meshes, as well as comprising two connectors, arranged in different meshes at the proximal end of the stent structure, and a conductive wire with a coupling element, to which the connectors are attached. The thrombectomy device is specially designed to remove, in a protective and reliable way for the patient, thrombi in the brain area, as are common in cases of stroke (stroke).
    [0002] Thromboembolic diseases, myocardial infarction, pulmonary embolism, peripheral thrombosis, organoembolisms, etc. they are typically originated by a thromboembolus (hereinafter abbreviated: thrombus), that is, a viscoelastic blood cluster, consisting of blood platelets, fibrinogens, coagulation factors, etc. that have attached themselves to a blood vessel and close it completely or partially. The closure of the organic arteries results, in this case, in an interruption of the tissue feeding, dependent on oxygen and nutrients. The interference of functional metabolism with functional loss is followed, within a short time, by the absence of structural metabolism with the dysfunction of the affected tissue (infarction). The human organs most frequently affected by this action are the heart and the brain. Such changes, however, also affect the arteries of the extremities and the pulmonary arteries. Venous thrombosis and thromboembolic blocks also occur, often in the veins of the legs and pelvis. The clinical picture of a thrombotic block of an intracranial bell, due to the interference of the venous drainage of the brain tissue, can produce severe cerebral bleeding.
    [0003] In view of the severity of clinical conditions, caused by thromboembolias and the frequency of these diseases, different techniques for dissolving or removing thrombi are known.
    [0004] Thus, it is known to treat such patients with thrombolytic media, such as streptokinase or uruchinase or with anticoagulants, which serves for thrombolysis or inhibition of thrombus growth. As these treatment methods are usually time-consuming, they are often combined with methods that serve for clinical fragmentation or removal of the thrombus, that is, embolism.
    [0005] In addition to open surgical interventions, according to the state of the art, transluminal interventional therapeutic forms, that is, endovascular, are progressively used, since these procedures are less invasive. Thus, it is known to remove the thrombus from the patient's body by means of suction catheters, generators of under pressure, or in mechanical form, with catheters provided with capturing baskets, spirals, hooks or similar units - see documents US 6,245,089 B1; US 5,171,233 A1, Thomas E. Meier et al., Stroke 2002 (9) 2232.
    [0006] The disadvantage of thrombolytic treatment methods is that after the time window has elapsed, they are only rarely successful. Also, the well-known transluminal devices are often unable to completely remove a thrombus, and there is also a danger that the thrombus or fragment will be released, being displaced into the bloodstream in smaller vessels, where they are difficult to reach and treat. In addition, devices known in the prior art, due to their dimensions and / or reduced flexibilities, are only insufficiently adapted for the removal of thrombi from specially reduced or sharply twisted vessels, such as those of the brain.
    [0007] From WO 2004/008991 A1, a clinical implant in the form of an open stent, for the treatment of aneurysms and other failed vascular formations, became known. This implant is conducted with the aid of a conductive wire to the place of use, being separated there. It has been proposed to employ this combination of implant and conductive wire for the extraction of thrombi, and, of course, the separation of the implant part of the conductive wire is suppressed. The disadvantage of this implant and conductive construction, however, is a relatively reduced tensile or molar force. The unit develops a shear effect that is not always sufficient on the thrombus, located on the vessel wall, so that residues remain in the container. The connection to the conductive wire through a (tear) structure leads, in particular, to a thinning of the proximal area of the structure under traction action, which is contrary to the efficiency of the unit.
    [0008] Based on the disadvantages linked to the state of the art, the task of the invention lies in providing a device for removing foreign bodies and thrombi from blood vessels, especially allowing the removal of thrombi from vessels of reduced structure and, in the case of , has good maneuverability in sharply twisted vessels and has an extensive action face.
    [0009] In accordance with the invention, this task is solved with a device of the species initially mentioned, which has a slit that extends in a spiral form on the lateral face of the stent structure, which at a proximal end of the stent structure , is covered by a tensioning handle.
    [00010] The device according to the invention consists of a cylindrical structure, which is also presented by stents, with a variety of meshes. Through two connectors it is connected with a conductive wire, which allows precise positioning. The connectors are arranged at the proximal end, in a mesh structure, and end in a coupling element, which, in turn, represents the distal end of the conductive wire.
    [00011] The term used here “proximal” means the side to be treated by the doctor, whereas “distal” means the side away from the doctor, for example from the structure of the stent or the conductive wire.
    [00012] The mesh structure of the stent can be a braided structure, that is, it consists of individual wires, however, preferably, a cut structure, in which a tube, of adequate diameter, with the aid of a laser, will be cut out the mesh structure. Usually, the material is a metal, but it can also be plastic. It must have sufficient elasticity, allowing a contraction to the diameter of a conventional catheter and, on the other hand, the release of the catheter, allowing the expansion to the desired and predetermined diameter.
    [00013] As stent materials are considered, in addition to iron alloys (noble steel, spring steel) and cobalt-chromium alloys, especially shape memorization alloys, possibly binary nickel-titanium alloys (nitinol) and alloys nickel-titanium-chromium ternaries (chromium alloys). Especially, nitinol is known for use in self-expanding stent structures in the neurovascular area.
    [00014] The device according to the invention is, in principle, a spatial structure, rolled into the shape of a tubular structure, with a slit that extends in a spiral or helix shape on the lateral face of the stent structure . In this case, this stent can represent a complete 360 ° spiral, but also a partial spiral, for example, about 180 ° or 120 °. The lateral face of the stent structure opens in the area of this crack, and the width of the crack at the site of use is also determined by the lumen of the container, since after the release of the catheter, the structure of the stent can only expand in such a way. extension that is allowed by the container lumen.
    [00015] To fix the structure of the stent, on the one hand, in a spatial form and, on the other hand, to provide a certain tension, a tensioning strap is extended at the proximal end of the stent structure over the slot. The tensioning handle increases the radial force of the self-expanding structure, but it also serves to hold the opposite edges of the stent structure tightly together in its convergent position along the crack.
    [00016] The thrombectomy device according to the invention may have, in addition to the proximal tension loop, other tension loops in the central and distal area. When using memorization materials with sufficient prestressing, any tensioning loop may also be dispensed with.
    [00017] The thrombectomy device according to the invention, will be so used that through a catheter it is moved to the place of use, being released there or directly in a thrombus and in a distal position of the thrombus. The device expands in the vessel and adjusts to the vessel's lumen. Either during fixation or retraction, the material of the thrombus gets caught in the mesh structure and in the retraction of the device for the catheter, it is dragged. Parts of the thrombus, adhering to the vessel wall, will be dragged by the shear effect of the meshes and edges along the crack. The thrombus will be retracted in the catheter, being removed from the body along with the catheter.
    [00018] During the extraction of the thrombus, the spiral path of the slit along the lateral face has the special advantage that the edges of the stent structure move along the slit, in case of traction, in a tangential direction along the circumference of the container wall This optimizes the shear effect. At the same time, the spiral path improves (decreases) the flexural stiffness, in such a way that a better adaptation to curvilinear cases is possible. This facilitates both the positioning and the extraction of thrombi from more complex vessel structures.
    [00019] The proximal loop improves the tracing of the radial force of the stent structure in the proximal area. In particular, the loop prevents a thinning of the stent structure and the stress requirement, as shown in the introduction to the catheter. At the same time, a better additional helical effect is achieved, as is also exerted by the meshes and edges of the stent structure.
    [00020] But it is important, especially, the improvement of the fixation force in the nearby area, which makes possible an optimal adaptation of the stent structure to the vessel lumen. At the same time, the areas of the stent, reciprocally separated by the stent, will be inhibited from moving in a reciprocal convergent manner.
    [00021] To enable a smooth introduction of the stent structure with the handle on the catheter, the tensioning handle points towards the distal end of the stent structure. This means that the loop of the handle is closed in a distal direction, however, in the opposite direction, still in a proximal direction, it forms, along with the connectors, a loop that converges on the coupling element, similar to the opening of a collecting basket.
    [00022] Alternatively, the fixation loop extends beyond the slit of the stent structure in an undulating path, eventually such that the loop acquires the path from the edge of the mesh structure on one side of the slit, continuing in the direction of the other side.
    [00023] According to a variant, the structure of the stent according to the invention may be closed at the distal end by a mesh structure at the distal end, so that there is accumulation of thrombus in the same way as a collecting basket.
    [00024] As already verified, the structure of the stent, according to the invention, is preferably cut from a cylindrical tube with the aid of a laser. This allows to assign to the different meshes a special cross section, for example, square, rectangular or trapezoidal. In the rectangular and trapezoidal modes, on the one hand, the narrow side of the cross section can be located on the external face, and, on the other hand, the long side, on the long side. It is preferred that the narrow side of both the rectangle, and especially the trapezoid, point in the direction of the container wall, which facilitates the penetration of the thrombus into the mesh structure, allowing good displacement of the thrombus in the mesh structure, allowing with good displacement of the mass of the thrombus when the stent structure expands.
    [00025] The connectors arranged at the proximal end of the stent structure, lead the proximal hives, bordering the slit, to a coupling element, in which they are joined. They are part of the stent structure and therefore consist of the same material.
    [00026] The conductive thread of the thrombectomy device according to the invention is a conventional conductive thread, as it is used for endovascular and, especially, neuroradiological purposes. It ends distally in the coupling element, which, in turn, receives the proximal ends of the connectors.
    [00027] The next coupling element can be a simple solder point, in which the conductive wire and the coupler are brought together. In addition, however, it can also be a conventional coupling element that allows the release of the cylindrical structure of the stent, which is especially indicated when a retraction is not indicated for clinical reasons, for example, because it would result in damage to the patient. In this case, the structure of the stent can remain in the patient's body, specifically as a stent, developing its action by the fact that it forms a channel in the thrombus; the thrombus will be pressed against the container wall by the mesh structure.
    [00028] For the latter case, the coupling element is, for example, a mechanical coupling element, which is suitable, at the exit of the catheter, to release the connectors. Numerous of these systems are described in the specialized literature. Hydraulic separation systems are also described. Especially suitable are electrolytic separation systems, in which an electrolytically corrosive part is dissolved by current action, cutting off the connection between the stent structure and the conductive wire. According to a first variant, the coupling element can specifically be formed as an electrolytically soluble component, and therefore, in a second variant, the connectors have a separation point of this type, that is, a separated separating element, which dissolves under the current action. Suitable as separating elements are pre-corroded noble steel elements, magnesium elements or cobalt-chromium alloys. Such systems are described in the literature.
    [00029] In the conformation of the proximal area of the cylindrical structure of the stent, a short finish of the connectors is preferred. The path between the proximal end of the mesh structure and the coupling element must be kept short. This shortens, on the one hand, the unused length of the device and increases, on the other hand, the tension in the pickup loop, formed with the fixing loop at the proximal end of the structure.
    [00030] According to a special modality, the distal area of the cylindrical structure of the stent can be expanded in a conical or trumpet shape, in order to allow, in this area, a good adaptation to the lumen of the recipient. When extracting thrombi from a container, a possibly large area of action is important, that is, the contact of the lateral face with the container wall. The larger the contact face, the greater the chance of completely removing the thrombus.
    [00031] The conductive wire and / or the structure of the stent may have marks, in a conventional way, sealed by X-rays, having, for example, the form of spirals or clamps.
    [00032] The invention will be explained in more detail by the attached figures. The figures show: figure 1 - in spatial presentation a first variant of the stent structure according to the invention; figure 2 - spatial presentation of the stent structure in figure 1; figure 3 - spatial presentation of a second variant of a stent structure according to the invention; figure 4 - spatial presentation of the stent structure in figure 3, with a conductive wire attached; figure 5 - perspective view of a stent structure according to the invention, with two connectors; figure 6 - presentation of the cut sections of the stent structure; figure 7 - schematic presentation of the thrombectomy device according to the invention; figure 8 - another modality in spatial presentation and figure 9 - spatial presentation of the stent structure in figure 8.
    [00033] Figures 1 and 3 show two variants of a cylindrical 1 stent structure, according to the invention, with the different meshes 3 and 4 and the connectors 5 and 5 '. Meshes 3 and 4 are of two different types, one type (3) having a wavy shape, and the others (4) have an arcuate conformation with two ends. In combined action, these two forms provide stability and flexibility for the overall structure.
    [00034] In the spatial presentation of figures 1 and 3, a slit or channel 7 extends through the structure of the stent, which, at the proximal end of the structure, is bridged by a tensioning loop 9. Slit 7 will be limited by the edges 10 and 10 'of the mesh structure. Slit 7 will be limited by the edges 10 and 10 'of the mesh structure. Slit 7 projects not parallel to the longitudinal axis of the structure, but in an oblique direction in the direction of the longitudinal axis, which is expressed, in the spatial representation, as a spiral path along the lateral face (see figure 2/4 ).
    [00035] The presentation in figures 1 and 3 is a spatial presentation of the cut stent 1 structure, and the spatial presentations are reproduced in figures 2 and 4. In the spatial presentation, meshes 3 are immediately borderline in meshes 3 ', of such that a tubular structure with a slit or channel 7 is constituted as a whole, which involves approximately half around the side face 8.
    [00036] The variants of figures 1 and 3 differ in the shape of connectors 5 and 5 ', which in the case of figure 3 are formed longer, being joined in a coupling element 11 (see figure 4). The coupling element 11 can, for example, be a corrosive electrolyte system, which allows to separate the structure of the stent 1 from the conductive wire 12 (see figure 43). In the variant according to figure 2, two separating elements 6.6 'can be provided for electrolytic separation.
    [00037] It is common to both embodiments that the gap 7 is bridged by the loop 9. The loop itself begins at the 10,10 'edges of the hives, and projects with its arc towards the distal side of the structure stent. This allows for smooth retraction of the stent structure in a catheter. With the connections 5 and 5 'adjacent, the fixing arch 9 constitutes a capturing loop, that is, opening of a collecting basket, which converges on the coupling element 11 (figure 4). For this purpose, the distal end of the stent structure can also be closed with a mesh structure.
    [00038] In the presentations of figures 2 and 4, which are the spatial reproduction of the stent structures of figures 1 and 3, the fillets of the stent structure, located on the dorsal side, are presented in clear form. It is possible to recognize the slit 7 that crosses, at the proximal end of the structure, the tension arch 9, which follows a spiral path in the direction of the right side, around the lateral face 8 of the stent structure 1. Slit 7 ends in position distal on the lower face of the stent structure and thus describes a rotation of about 180 °.
    [00039] Figure 5 shows a spatial presentation of a stent structure according to the invention, with connectors 5 and 5 'having hooks facing inward, fitting into a corresponding socket of a coupling element 11 of a conductive wire 12 As long as the coupling element meets the proximal end of connector 5 and 5 'in a catheter, the structure of stent 1 will be coupled to the conductive wire. When displacing the catheter, the connection between the 5.5 'connectors and the coupling element 11 is extinguished and the structure is released, in the form of a stent, to remain in the vascular system. Decoupling will take place, however, in special (emergency) cases, eventually when the device cannot simply be retracted back into the catheter.
    [00040] The structure of the loop, consisting of the arch 9 and connectors 5.5 'and the path of the fillets 12 of the stent structure along the lateral face 8, can clearly be seen in figure 5, which, with its edges, can serve to act on the material of the thrombus to be removed, cutting this material from the vessel wall.
    [00041] Figure 6 shows the two preferred modalities of the fillets 12 with rectangular and trapezoidal cross-section, with the narrow side pointing towards the lateral face 8 of the stent 1 structure, that is, the vessel wall 13. These variants finishes guarantee the necessary stability of the mesh network on the one hand, and, on the other hand, a good shear and displacement effect on the thrombus.
    [00042] Figure 7 shows, schematically, the constitution of a thrombectomy device according to the invention, with the conductive wire 12, the coupling element 11, the proximal connection area with the 5.5 'connectors; the action area with the lateral face 8 and the distal area 13 with a trumpet-shaped widening.
    [00043] Figure 8 shows another modality of a thrombectomy device according to the invention, coinciding, in essential points, with the respective device according to figure 1. In relation to this figure, the version of the fixation 9, which covers the proximal gap 7, that is, exceeds in the form of a bridge. In this case, the fixing loop 9 follows the path of the side face, that is, of the edge of the mesh structure 10 with its wavy path and continues in the direction of the opposite edge 10 '. The 5.5 'connectors with the sequential mesh edges and the fixation loop 9 form, in all, a kind of loop, similar to the opening of a collecting basket, which facilitates the retraction of the thrombectomy device in a catheter and, at the same time, it is suitable for cutting thrombus or thrombus residues, attached to the container walls.
    [00044] It is understood that figure 8, as well as figures 1 and 2, show the device, according to the invention, in a cut, that is, spatial state. Effectively, it is a spatial tubular structure, fitted inside a tube, as shown in figure 9.
    [00045] The presentation in figure 9 shows the thrombectomy device of figure 8 in spatial representation, with the fillets located on the front side and meshes being presented with solid lines, and those located on the dorsal part, are drawn in dashed form . The two connectors 5 and 5 'are joined in the coupling element 11 and form, with the edges of meshes there sequentially and with the fixing handle 9, the "pickup basket" described above. It is possible to recognize the spiral-shaped path of the slot 7. The slot 7 will be limited by the edges of meshes 10 and 10 ’, being bridged by the fixing loop 9.
    [00046] In the figures, identical reference numbers represent identical situations.
    权利要求:
    Claims (13)
    [0001]
    1. Thrombectomy device with a stent structure (1) essentially cylindrical, which presents a variety of meshes (3,4), as well as two connectors (5.5 '), arranged in different meshes (3) at the proximal end of the stent structure (1) and a conductive wire (2) that has a coupling element (11), in which the connectors (5.5 ') are coupled, characterized by a slot (7), which extends, in spiral shape, on the lateral face (8) of the stent structure (1) and a tensioning loop (9) that surpasses the slit (7) in the proximal end of the stent structure (1).
    [0002]
    2. Device according to claim 1, characterized by the fact that it consists of a shape memorizing material, preferably nitinol or a nickel-titanium-chromium alloy.
    [0003]
    Device according to claim 1 or 2, characterized by the fact that the tensioning loop (9) points with its arc towards the distal end of the stent structure (1).
    [0004]
    Device according to any one of claims 1 to 3, characterized in that the tensioning loop (9) and the connectors (5.5 ') form a loop that converges on the coupling element (11).
    [0005]
    Device according to any one of claims 1 to 4, characterized by the fact that it has one or more other loops (9) in the central and / or distal part of the stent structure (1).
    [0006]
    6. Device according to any one of claims 1 to 5, characterized by the fact that the structure of the stent (1) is sectioned from a tube, with rectangular or trapezoidal fillet cross sections.
    [0007]
    7. Device according to claim 6, characterized by the fact that the cross sections of the fillet form, with its narrow side, the lateral face (8) of the stent structure (1).
    [0008]
    Device according to any one of claims 1 to 7, characterized in that the structure of the stent (1) is separable from the conductive wire (2) by mechanical, hydraulic or electrochemical process.
    [0009]
    Device according to claim 8, characterized by the fact that the coupling element (11) is formed as a separating element.
    [0010]
    10. Device according to claim 8, characterized by the fact that it has two points of separation, preferably with electrochemical separation.
    [0011]
    Device according to any one of claims 1 to 10, characterized in that the coupling element (11) is arranged at the periphery.
    [0012]
    Device according to any one of claims 1 to 11, characterized in that the distal end of the stent structure (1) is enlarged in a conical or trumpet direction.
    [0013]
    Device according to any one of claims 1 to 12, characterized by marking elements.
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    法律状态:
    2018-12-11| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-10-08| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-09-15| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-12-01| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/05/2012, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102011101522.5|2011-05-13|
    DE102011101522A|DE102011101522A1|2011-05-13|2011-05-13|thrombectomy|
    PCT/EP2012/002060|WO2012156069A1|2011-05-13|2012-05-14|Thrombectomy device|
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