• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
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  • 优先权
    • 专利摘要:
    ACOMODATIVE INTRAOCULAR LENS, PERIPHERAL BELT, AND IMPLANTATION METHOD.An intraocular accommodation lens (AIOL) adapted for implantation in a capsular bag includes an external shell, a valve, and a force transfer set. The outer shell includes at least one surface modification over at least one periphery of the outer shell to promote connection with the capsular bag. The valve is configured to allow injection of a filler. The force transfer assembly in the outer shell is adapted to transfer forces from the capsular bag to modify the shape of the filled outer shell in response to changes in the capsular bag shape.
    公开号:BR112013028038A2
    申请号:R112013028038-7
    申请日:2012-05-22
    公开日:2020-08-25
    发明作者:Stephen J. Van Noy
    申请人:Novartis Ag；
    IPC主号:
    专利说明:

    <7 1 “ACCOMODATING INTRAOCULAR LENS, PERIPHERAL BELT, AND, IMPLEMENTATION METHOD”
    FIELD OF THE INVENTION This invention generally relates to the field of lenses: intraocular (IOL) and, more particularly, accommodative IOLs. Background of the Invention The human eye, in its simplest terms, works to provide vision by transmitting light from a clear external portion, called the cornea, which focuses the image through a crystalline lens on the retina. The quality of the focused image depends on many factors including the size and shape of the eye, and the transparency of the cornea and lens. The lens is held in place within the posterior chamber of the eye by a membrane known as the capsular sac or posterior capsule, immersed in the aqueous humor. The shape of the lens and the refractive index of the lens in relation to aqueous humor determine where the rays of light are focused on the retina. When age or illness causes a lens to become less transparent, vision deteriorates because of diminished light that can be transmitted to the retina. This deficiency in the lens of the eye is clinically known as a cataract. An accepted treatment for this condition is surgical removal of the lens and replacement of the lens function with an artificial intraocular lens (IOL). Cataract crystals are often. removed by a surgical technique called phacoemulsification. During this procedure, an opening is made on the anterior side of the capsular bag, i a thin membrane enclosing the natural lens. A thin phacoemulsification cutting tip is inserted into the diseased lens and vibrated ultrasonically. The vibrating cutting tip liquefies or emulsifies the lens so that the lens can be aspirated out of the eye. The diseased lens, once removed, is replaced by an artificial lens. In the natural lens, the multifocality of distance and vision of
    2 nearby is provided by a mechanism known as accommodation. The natural lens, at the beginning of life, is soft and contained within the capsular bag. The sac is suspended from the ciliary muscle by the zonules. Relaxation of the ciliary muscle tightens the zonules, and stretches the capsular sac. As a result, the natural lens tends to flatten out. The tightening of the ciliary muscle relaxes the tension: on the zonules, allowing the capsular sac and the natural lens to assume a more rounded shape. In this way, the natural lens can be alternatively focused on near and far objects. As the lens ages, it becomes harder and is less able to change its shape in relation to the tightening of the ciliary muscle. This makes it more difficult for the lens to focus on nearby objects, a clinical condition known as presbyopia. Presbyopia affects all adults over the age of approximately 45 or 50. When a cataract or other illness requires removal of the natural lens and replacement with an artificial intraocular lens ("IOL"), alOL used to replace the natural lens was often a monofocal lens. These lenses do not alter the potency in response to the movement of the capsular bag, requiring the patient to wear a pair of glasses or contact lenses for near vision. However, there are several examples in the prior art of bladder-type or bag-type intraocular lenses that consist of an external flexible film filled with a viscous gel. The resulting lens completely fills the capsular bag and is very soft and foldable, just like the natural lens. See, for example, US Patent Nos.
    4,373,218 (Schachar), 4,585,457 (Kalb), 4,685,921 (Peyman), 4,693,717 (Michelson), 5,275,623 (Sarfarazi), 4,822,360 (Deacon), 5,489,302 (Skottun) e6217. 612 (Woods). However, in order to provide accommodation, the movement of the ciliary muscle must be properly transmitted to a lens system through the capsular bag, and none of these references expose a mechanism to ensure that there is a close connection or fixation between the capsular bag and a lens system.
    o Therefore, a need continues to exist for a stable and safe, accommodating intraocular lens system and method for implantation that provide accommodation over a wide and useful range.
    Brief Summary of the Invention i 5 An intraocular accommodation lens (AIOL) adapted for implantation in a capsular bag includes an external shell, a valve, and a force transfer set. The outer shell includes at least: a modification of the surface over at least one periphery of the outer shell to promote connection with the capsular bag. The valve is configured to allow injection of a filler. The force transfer assembly in the outer shell is adapted to transfer forces from the capsular bag to modify the shape of the filled outer shell in response to changes in the capsular bag shape. Brief description of the drawings Figure 1 is an enlarged cross-sectional view of the lens according to a particular embodiment of the present invention.
    Figure 2 is an enlarged cross-sectional view of the lens in Figure | showing the lens implanted in a capsular bag.
    Figure 3 is an enlarged cross-sectional view of the lens in Figure 1 showing the lens implanted in a capsular bag and material being injected into the lens until approximately the unconditioned state.
    Figure 4 is an enlarged cross-sectional view of the lens in Figure 1 showing the lens implanted in a capsular bag and material being removed from the lens. | 'Figure 5 is an enlarged cross-sectional view of the lens in Figure 1 showing the lens implanted in a capsular bag and being in the “accommodated state.
    Figure 6 is a flow chart showing a method of implanting an inflatable accommodation lens according to flight 4 particular embodiments of the present invention; Figure 7 illustrates a double optical accommodation IOL according to a particular embodiment of the present invention; Figures 8A, 8B, and 8C illustrate various modalities of a double optics AIOL according to particular embodiments of the present invention, when viewed along the optical axis; | Figure 9 is a flow chart showing a method of | example implantation of a dual optical AIOL according to particular embodiments of the present invention; and Figure 10 illustrates a peripheral brace that can be used in | conjunction with various embodiments of the present invention. Detailed Description of the Invention Several embodiments of the present invention can provide an improved accommodation lens by promoting adhesion of the capsular bag around the mechanical characteristics of the accommodation IOL. This provides a more robust mechanical connection between the bag and the IOL to allow the bag to flatten and relax, as opposed to the strength of the ciliary muscles, to move the lens. Changes in the shape of the capsular bag are, in turn, used either to deform the lens to produce a change in power (similar to the accommodation of the natural lens) or to produce a change in IOL power by separating two optical elements.
    Various embodiments of the present invention also include mechanical structures for translating the force produced by movement of the capsular bag to forces that produce either deformation of the lens or separation of optical elements from the lens. By combining this with strong adhesion of the capsular bag to the IOL at particular points along the mechanical structure, particular modalities of IOLs according to the present invention advantageously provide increased mechanical efficiency and a greater degree of accommodative change in the optical power of the IOL.
    "As best seen in Figure 1, a lens 10 according to a particular embodiment of the present invention generally consists of an outer shell 12 that defines inner void space 13, which contains the inner filler material 14. The outer shell 12 is preferably i 5 formed in any suitable overall diameter or length, for example, around 10 millimeters, for implantation in the capsular bag of the eye.The outer shell 12 is preferably made of a soft, foldable material, which is inherently resistant to formation of posterior capsular opacification ("PCO"), such as a soft acrylic. In certain embodiments, the material of the outer shell 12 can be relatively more elastic than the capsular bag, so that the outer shell 12 can be moved by the capsular bag with relative ease The outer shell 12 contains a filling valve 16, which allows the filling material 14 to be injected into, or removed from, the empty space 13.
    The outer shell 12 can also include a force transfer structure, such as a plurality of radial reinforcement ribs 18 having an appropriate spacing, for example, 30 °, and / or can be attached to a peripheral band surrounding the lens 10 ( as described in more detail below). In the embodiment shown, the lens 10 also includes live joints 21 on the periphery, in order to facilitate the reshaping of the surfaces. In particular embodiments, a peripheral brace can be attached to the living joint assembly to transfer forces from the capsular bag to the living joints. The outer shell 12 may also contain sharp peripheral corners 20 designed to prevent equatorial cell proliferation on the optical surfaces of the lens 10, but cell adhesion is preferably encouraged around the joints 21 on the lens periphery to improve the mechanical transfer efficiency. between the capsular bag and the lens 10.
    At least part of the outer shell 12 is coated with surface modification 22, which may include coatings, texturing,.
    or another appropriate variation designed to promote protein adhesion.
    Examples of such coatings include complementary proteins, growth factors for the capsular sac, chitin or other organic chemical components used in signaling cell growth conditions. A: polymer structure used to form lens 10 can be protein fortified, so that the lens material itself has a surface that encouraged protein binding. Other appropriate surface modifications include nano-channels or other structures that allow cell interpenetration into the lens structure. Such structures may also include coatings or treatments to promote cell growth and binding within the cell network / lens that is | interpenetrate. Yet another appropriate surface modification includes: using biocompatible adhesives. ! The filling material 14 is preferably a liquid,! gel, or low molecular weight polymer with a higher refractive index than that of the surrounding aqueous humor. Such materials may include (but are not limited to) silicone oil, perfluoro, and cross-linked or non-cross-linked polymer gels. It is also preferable to minimize the loss of filler material 14 due to diffusion, so the outer shell 12 should preferably be relatively impermeable to the filler material 14 and the surrounding aqueous humor. As best seen in Figure 2, lens 10 can be implanted in capsular bag 24 in an unfilled state. As seen in Figure 3, the internal void space 13 is then filled with filler material 14 through valve 16 using an appropriate instrument, such as cannula 26, so that lens 10 approaches the shape of the natural lens in a state disengaged, which results in the front surface 30 of the outer shell 12 being relatively flat. In the modality; | shown in Figure 2, the front surface 30 changes shape
    ”| considerably during accommodation, while the posterior surface remains relatively unchanged in shape, but alternative modalities could have both the anterior surface and the posterior surface changing shape to a lesser or greater degree.
    An advantage of the thickening of the l 5 - posterior surface or of making the posterior surface relatively more rigid is that the posterior surface could be relatively fixed in order to more easily allow the spherical / or toric correction to be used in the lens 10. Optics diffractive and / or multifocal materials could also be incorporated into the surfaces.
    When lens 10 is overfilled, zones 28 are in a relaxed position.
    Lens 10 is left in this overfilled condition for a period of time sufficient for the adhesion of proteins to form between | external shell 12 and capsular bag 24, for example, 2-4 weeks.
    How else! well seen in Figure 4, after the adhesion of proteins has been formed between the outer shell 12 and the capsular bag 24, enough filling material 14 is removed from the void 13 through the valve 16 for the lens 10 to adopt the shape of an unconditioned lens, as best seen in Figure 5, with zonules 28 in tension and anterior surface 30 having a more rounded shape in relation to the overfilled state, as shown by arrows 32. Lens 10 can also be mechanically tensioned for the state accommodated, so that when the capsular bag relaxes, the standard tendency of lens 10 is to restore itself to the accommodated state.
    For example, the living joints 21 may have a spring action which tends to tension the front surface of the lens 30 to the accommodated shape.
    Figure 6 is a flow chart 100 showing an example implantation method according to particular embodiments of the present invention.
    In step 102, an inflatable accommodation lens ("AIOL") is provided, with a surface modification to promote protein adhesion with the capsular bag.
    In step 104, the AIOL is implanted in an unfilled state.
    In step 106, AIOL is overfilled to facilitate contact with the
    F '8 capsular bag.
    In step 109, the capsular bag is allowed to cure around the AIOL long enough to allow the connection between the capsular bag and the AIOL.
    In step 110, filling material is removed from the ATOL to reach an unconditioned state for the AIOL. Figure 7 is a cross-sectional view of an AIOL of: double optics 200 according to another embodiment of the present invention.
    For the purposes of this description, "dual optics" refers to an AIOL including at least two optical elements, but such a dual optical AIOL could also include additional optical elements.
    The dual optical ATOL 200 includes an optical front element 202 and an optical rear element | 204. Preferably, one of the front optical element 202 or the rear optical element 204 has a positive power, and the other has a negative power so that the difference between the powers is relatively large and a change in spacing between the optical elements 202 and 204 produces a significant change in the total optical power.
    One or both of the surfaces may also include spherical, toric, diffractive, and / or multifocal correction.
    Although both optical elements 202 and 204 are shown inside the capsular bag, AIOL 200 could include an anterior optical element fixed in groove 202 or even one: AIOL 200 also includes interlocking characteristics 206 between optical elements 202 and 204. The interlocking characteristics 206 are positioned peripherally around the optical elements 202 and 204, and the interlocking characteristics 206 also include surface modifications, such as those described above, to —promote the connection of the capsular bag to the interlocking characteristics 206. The characteristics interlocking elements 206 can be formed integrally, so that the entire AIOL 200 is a single piece, or they can alternatively be complementary characteristics, attached to their respective optical elements 202 and 204 so that the characteristics of
    The interlock 206 is connected to each other before or during implantation.
    Although the interlocking features 206 are illustrated in an integrated live hinge configuration, other arrangements could also work properly, including arrangements using the hook and lock or hinge pin.
    In the illustrated embodiment, the 4 interlocking features 206 are configured to keep the optical elements 202 and 204 spaced apart from each other in the unconditioned state i to prevent adhesion.
    CC Because the capsular bag is firmly attached to the interlocking features 206, the capsular bag pulls out the interlocking features 206 when flattened.
    The interlocking features 206 are shaped so that the optical elements 202 and 204 are pulled together when the interlocking features 206 are pulled out.
    The interlocking features 206 are also shaped to store mechanical energy when the optical elements 202 and 204 are pulled together.
    For example, interlocking features 206 may include spring turns that are twisted by pulling outwardly over interlocking features 206. Thus, when the capsular bag is flattened, ATOL 200 | 20 will be pulled into an uncomfortable state (lower power). When the capsular bag relaxes, the interlocking characteristics 206 release the | mechanical energy stored to force optical elements 202 and 204 away, increasing the optical power of the ATIOL 200 to provide accommodation.
    In order for the capsular bag to have adequate tension to pull the interlocking characteristics 206, the capsular bag must be firmly connected to the interlocking characteristics 206 in the unconditioned state.
    To facilitate this connection, AIOL 200 may include retention features, such as clips, that retain optical elements 202 and 204 in the unconditioned state, with mechanical energy being stored at '+ 10 in the interlocking features 206. Retention features can be left in place for two or more weeks, while post-surgical healing and ligation of the capsular bag are being performed.
    Following the connection process, the retention features can be removed or - otherwise disabled, such as by directing. laser pulses to separate the retention characteristics.
    The retention characteristics could also be made biodegradable, so that they could corrode over time and eventually dissolve after the capsular bag has been well attached.
    Once when the retention characteristics are no longer retaining or maintaining the | ! optical elements 202 and 204 together, the stored mechanical energy | in the spring elements can be released when the tension on the bag | capsular is released, providing the accommodation as described above.
    Figures 8A, 8B, and 8C illustrate several different modalities of the interlocking characteristics 206 when viewed along the optical axis.
    In the embodiment shown in Figure 8A, the interlocking characteristics 206 form a continuous circle with surface modification on the periphery of the AIOL 200 to facilitate attachment to the capsular bag.
    In the embodiment shown in Figure 8B, the interlocking features 206 include windows to facilitate the interpenetration of capsular cells into the interlocking features 206. In the embodiment shown in Figure 8C, the interlocking features 206 are joined in six T-shaped junctions that have surface modifications to promote capsular cell growth and binding to interlocking characteristics 206. The —modalities illustrated are examples only, and any structure capable of storing mechanical energy that has appropriate surface modifications to promote binding to the capsular bag may be appropriate for - interlocking characteristics 206. Figure 9 is a flow chart 300 illustrating a method of
    . , 1 example for implanting a double optical AIOL, as illustrated in Figure 7. In step 302, a double optical AIOL with interlocking characteristics having surface modifications to promote connection to the capsular bag is provided. In step 304, holding characteristics a i 5 —AIOL200 in an unconditioned state are provided. In step 306, AIOL * is deployed. In step 308, the capsular bag is allowed to cure and bind to AIOL. In step 308, the retention characteristics are disabled to allow the AIOL 200 to move freely in response to the movement of the capsular bag.
    Figure 10 illustrates a peripheral strap 400 suitable for: use with any of the preceding modalities, described above, although it is illustrated particularly with the lens 10 in Figure 1. The peripheral strap 400 serves to improve the mechanical connection with the capsular bag by preserving the tension in the anterior and posterior zonules when the capsular bag heals around the lens 10. One difficulty that can arise with the accommodation of AIOLs is usually that AIOL can be something more boring than the natural lens. This causes the anterior and posterior zonules to be more stressed when the capsular sac heals around the IOL than they would be around the natural lens. The peripheral brace 400 is wide enough to overcome the area of the capsular bag where the zonules are affixed, thus preventing the capsular bag from flattening in this area and preserving the zonular tension. This advantageously improves the transfer of force from the capsular bag. The peripheral strap 400 can also be attached to the living joints 21 illustrated, for example, in Figure 1, to provide additional influence for the capsular bag forces to modify the shape of the lens 10. The peripheral strap 400 can also be made of a material elastic that is mechanically tensioned to the accommodated state, allowing the lens 10 to more easily restore itself to an accommodated position when the tension in the capsular bag is relaxed.
    mm SS v Ú 1 2 As with other modalities described above, the peripheral strap 400 has surface modifications that promote the connection of the capsular bag to the peripheral strap 400. The peripheral strap 400 is mechanically connected to lens 10 or to the interlocking characteristics 206 of double optic AIOL - 200 in order to preserve a robust mechanical connection between the capsular bag and AIOL * movement.
    This mechanical connection can be made, for example, by sizing the peripheral belt 400 so that it fits tightly around the AIOL, by adhesion of the peripheral belt 400 to the AIOL using adhesive, or by copolymerization or otherwise forming in a different way peripheral belt 400 with AIOL.
    Peripheral brace 400 may also include a corner - | acute for the prevention of PCO.
    Various embodiments of the present invention, including examples of AITOLs that promote binding to the capsular bag and facilitate the AIOL's mechanical response to changes in the capsular bag to produce accommodation, have been provided.
    This description is given for purposes of illustration and explanation.
    It will be apparent to those skilled in the relevant art that changes and modifications can be made to the invention described above without departing from the scope of the invention as claimed.
    Such modifications include, for example, adapting any of the modalities described for the supply of medication or modifying such characteristics, such as the peripheral brace, to reduce positive or negative dysphotopsia.
    权利要求:
    Claims (28)
    [1]
    1. Intraocular accommodation lens (AIOL) adapted for implantation in a capsular bag, characterized by the fact that! comprises: i i '5. - an outer shell, the outer shell including at least =; a surface modification on at least one periphery of the outer shell to promote connection with the capsular bag; a valve configured to allow injection of a filler; and a force transfer assembly in the outer shell adapted to transfer forces from the capsular bag to modify the shape of the filled outer shell in response to changes in the shape of the capsular bag.
    [2]
    2. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that it further comprises at least one sharp edge shaped to retain the capsular bag to reduce posterior capsule opacification.
    [3]
    3. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that it also comprises at least one living articulation in an AIOL periphery.
    [4]
    4, Intraocular accommodation lens (AIOL) according to claim 1, characterized in that a portion of the outer shell that does not have at least one surface modification is treated to prevent cell growth of the capsular bag.
    [5]
    5. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that the force transfer set comprises a plurality of reinforcement ribs.
    [6]
    6. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that the filling material
    It's the". IN ““ Úu) kj; P ECC “> 2>" "956222 22": 4 rt 2 comprises a polymer gel.
    [7]
    7. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that the outer shell further comprises a peripheral band and in which at least one surface modification is on the peripheral band. -
    [8]
    8. Intraocular accommodation lens (AIOL) according to claim 1, characterized by the fact that at least one surface modification comprises nano-texturization.
    [9]
    9. Intraocular accommodation lens (AIOL) according to claim 1, characterized in that the at least one UU surface modification comprises a coating including growth factors for the capsular bag. : |
    [10]
    10. Dual optical intraocular accommodation lens (AIOL) | adapted for implantation in a capsular bag, characterized by the fact that | —Who understands: an anterior approach; a posterior optic; and interlocking characteristics connected to the optic anterior to the posterior optic, the interlocking characteristics having at least one surface modification to promote connection of the capsular bag to the interlocking characteristics, in which the interlocking characteristics are adapted to store mechanical energy when pulled out by the connected capsular bag and in which the interlocking characteristics comprise spring turns.
    [11]
    11. Double optical intraocular accommodation lens (AIOL) according to claim 10, characterized by the fact that the interlocking characteristics comprise living joints. :
    [12]
    12. Dual optical intraocular accommodation lens (AIOL) according to claim 10, characterized by the fact that at least
    O and SS SS, ÊÍ]) ZA% 2)! / Mr “lei asi Mt in af” º $ * tMRRI) min ec 7 3 minus a surface modification comprises nano-texturization. '
    [13]
    13. Double optical intraocular accommodation lens (AIOL) according to claim 10, characterized in that the at least one surface modification comprises a coating including - growth factors for the capsular bag.
    [14]
    : 14. Double optical intraocular accommodation lens (AIOL) according to claim 10, characterized by the fact that it also comprises a peripheral brace connected to the interlocking characteristics.
    [15]
    15. Dual optical intraocular accommodation lens (AIOL) - according to claim 10, characterized by the fact that it also comprises retention characteristics that store mechanical energy in the interlocking characteristics to allow the interlocking characteristics to be linked to the capsular bag .
    [16]
    16. Peripheral strap adapted to attach to an intraocular accommodation lens (AIOL) inside a capsular bag attached to a plurality of zonules in a display region, the peripheral strap, characterized by the fact that it has at least one surface modification to promote connection to the capsular, the peripheral band having a width covering the region where the capsular bag is attached. | 20
    [17]
    17. Peripheral belt according to claim 16, | characterized by the fact that the peripheral belt is sized to fit tightly around the AIOL to transfer forces from the capsular bag to the AIOL. i
    [18]
    18. Peripheral belt according to claim 16, - characterized by the fact that the peripheral belt is bonded to the AIOL with adhesive. :
    [19]
    19. Peripheral belt according to claim 16, characterized by the fact that the peripheral belt is integrally formed with AIOL.
    [20]
    20. Peripheral strap according to claim 16,
    o | characterized by the fact that at least one surface modification comprises nano-texturization.
    [21]
    21. Peripheral belt according to claim 16, characterized in that the at least one surface modification 5 comprises a coating including growth factors for the capsular sc bag.
    [22]
    22. Method of implanting an intraocular accommodation lens (AIOL) in a capsular bag, characterized by the fact that it comprises: providing an AIOL comprising an outer shell, the outer shell including at least one surface modification on at least one periphery of the external shell to promote connection with the capsular bag, a valve configured to allow injection of a filling material, and a force transfer set in the adapted external shell | 15 —to transfer forces from the capsular bag to modify the shape of the filled outer shell in response to changes in the shape of the capsular bag; overfilling the AIOL using a filler; allow the capsular bag to attach to the outer shell of the AIOL; and i removing filler material from the AIOL to place the AIOL in an uncomfortable state.
    [23]
    23. The method of claim 22, characterized in that the filler material comprises a polymer gel.
    [24]
    24. Method according to claim 22, characterized by the fact that at least one surface modification comprises nano-texturization.
    [25]
    25. The method of claim 22, characterized in that the at least one surface modification comprises a coating including growth factors for the capsular bag.
    * '5
    [26]
    26. Method of implantation of a double-optic intraocular lens (AIOL), characterized by the fact that == comprises: providing a double-optic AIOL comprising an optic | | 5 anterior, a posterior optic, and interlocking characteristics connected to o. anterior to posterior optics, and retention characteristics, the interlocking characteristics having at least one surface modification to promote connection of the capsular bag to the interlocking characteristics, in which the interlocking characteristics are adapted to store mechanical energy in spring turns when pulled out by the attached capsular bag and the retention characteristics are adapted to store mechanical energy in the interlocking characteristics to allow the interlocking characteristics to be linked to the capsular bag; implant AIOL with double optics in the capsular bag; allow the capsular bag to connect to the AIOL with double optics; and release the retention characteristics.
    [27]
    27. Method according to claim 26, characterized in that releasing the retention characteristics comprises removing the | retention characteristics. | | 28. The method of claim 26, characterized in | by the fact that releasing the retention characteristics comprises separating the. retention characteristics with a laser. |
    SS | Aa | ! 22 50 Yes | 16 prcrb ar, 12 | bi JJ] A 22 | THERE! S GO 18 18 BIZ »GO” 14 21 -20 CZ = 2 Air. ”P 22 Ca O 22: 13 Fig. 1 —— É - 18 TETE ET 6 18 TR GE EU 21 14 21H EE READ == / PAD a ] 28 & Z 28 A.
    PP »24 A CRIIIaa III 24 13 Fig. 2
    | YO 217 <| TA o | =) LO 18 CEILING | = ——. Ace | E 4 2H E | SS 14 LAZ222a | 28 x H 28! A. | ”” »24 2 24 13 Fig. 3!
    FAN CAL ce dd AE - 18 CRE AA 16 18 GEE EAN 2 IF Those = D PLAY 2 Jos 28 q, = 28 A eax. Da ”'24 A CCIIIIIaaaInardRO 24: 13 | : Fig. 4 o 37 P JpÚpuW [CC, at 18 DPS | ES 16 18 GEZX E 14 21 ES Es 2Ê JIJ VA222 = 2. PA) [GF SS 28 x ”
    [28]
    28 A, fd 24 aaa 24 13 Fig. 5 | | | x 4 o 4/7 is Cínício) O 100 *. Provide intraocular lens for accom-. 102 inflatable portion (AIOL) with surface modification to promote the connection of the capsular bag. 104 Implant an intraocular accommodation lens (AIOL) in an unfilled state. 106 Overflow intraocular accommodation lens (AIOL) with filler: 108 Allow the capsular bag to attach to | intraocular accommodation attempt (AIOL) 110 Remove filling material to reach the unconditioned state | | 7 | Fig. 6 - + j
    SA Fig. 7: ”” | SE 206 S Fig. 8C | Fig. 68 | or: 6/7 »Grs) 2 Provide 302 double optical accommodation (AIOL) intraocular lens with interlocking characteristics to store mechanical energy provide retention characteristics that store 304 mechanical energy in the 306 interlocking characteristics double-optic lacomodal intraocular (AIOL) 308 allow the connection of the capsular bag. 310 release the retention characteristics. :! Fig. 9 | | | | ii:> 35; 5 <P22A02ÓºgÓAÓOAYDQ AT A 20009 ““ P “O“ ““ ““ “” SS OCO a at. - | 'X TT
    NX: JÚr "A" ad>, CQC ATA SN = x PD cb ”» Fig. 10 |
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    同族专利:
    公开号 | 公开日
    TW201300089A|2013-01-01|
    ES2615747T3|2017-06-08|
    US9186243B2|2015-11-17|
    CA2833317C|2019-06-11|
    CN103561684A|2014-02-05|
    AU2012262814B2|2016-07-07|
    TWI549665B|2016-09-21|
    US20120310343A1|2012-12-06|
    RU2013157799A|2015-07-10|
    AU2012262814A1|2013-10-31|
    AR086619A1|2014-01-08|
    WO2012166435A1|2012-12-06|
    JP2014521394A|2014-08-28|
    RU2610545C2|2017-02-13|
    EP2685935A4|2015-05-13|
    CA2833317A1|2012-12-06|
    JP6023182B2|2016-11-09|
    EP2685935A1|2014-01-22|
    CN103561684B|2016-11-09|
    EP2685935B1|2016-11-30|
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    法律状态:
    2020-10-20| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2020-10-20| B25A| Requested transfer of rights approved|Owner name: ALCON INC. (CH) |
    2020-10-27| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-02-09| B11B| Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements|
    2021-11-23| B350| Update of information on the portal [chapter 15.35 patent gazette]|
    优先权:
    申请号 | 申请日 | 专利标题
    US201161491819P| true| 2011-05-31|2011-05-31|
    US61/491819|2011-05-31|
    PCT/US2012/038973|WO2012166435A1|2011-05-31|2012-05-22|Accommodative intraocular lens and method of implantation|
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