• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    method and device for extracting information by flicker pulse. a method for extracting information by scintillation pulse includes the following steps: 1. obtaining a peak value of the scintillation pulse in a given variation of the energy spectrum and selecting at least three voltage limits according to the peak value; 2. determine the time that the scintillation pulse passes through each voltage limit, in which each time value and its respective voltage limit form a sampling point; 3. select multiple sampling points as sampling points for reconstruction and reconstruction of the impulse wave; 4. obtain the original flicker pulse data using the reconstructed pulse wave. a device for extracting information by flickering pulse includes a voltage limit setting module (100), a time sampling module (200), a pulse reconstruction module (300) and an information acquisition module (400 ).
    公开号:BR112013026944B1
    申请号:R112013026944-8
    申请日:2011-05-10
    公开日:2020-09-29
    发明作者:Qingguo Xie；Peng Xiao；Xi Wang；Na Li；Yuanbao Chen；Wei Liu
    申请人:Raycan Technology Co., Ltd. (Su Zhou)；
    IPC主号:
    专利说明:

    FIELD OF THE INVENTION
    The present invention relates to the field of detectors in high energy physics and signal processing and, in particular, to a device method for obtaining flicker pulse information, which is applicable to the detection of high energy particles, nuclear medical imaging, etc. BACKGROUND OF THE INVENTION
    In most of the field of high energy particle detection and in the field of medical imaging, such as computed tomography (referred to as CT), positron emission tomography (referred to as PET) and single photon emission computed tomography (referred to as SPECT), the Flicker pulse signal collected and processed by the data acquisition system is an observable electrical signal, obtained by converting visual light through a photoelectric conversion device and visible light and visible light is obtained by converting high energy particles (such as x ray θ x ray) through a scintillation crystal. A typical waveform of the scintillation pulse is shown in Figure 1. The time information of the scintillation pulse is obtained by measuring the time from a relatively fixed point on the pulse. The energy information of the scintillation pulse is obtained by calculating the total volume of electrical charges carried by the pulse, that is, the area of the pulse wave. The scintillation pulse position information is the relative position (X, Y) of the scintillation pulse in the detector obtained by comparing four "angular signals" generated by the detector.
    In a traditional scintillation pulse data acquisition system, the information obtained is based on the analog circuit or the digital-analog hybrid circuit. The high speed scintillation pulse signal needs to be processed by analog amplification, filtering, integration and the like and displacement may occur for the analog circuit such as temperature and time changes. Therefore, it is difficult to maintain the detector's performance in an ideal state. In addition, analog amplification, filtering and integration are performed according to specific characteristics of a given detector. Therefore, the method that obtains information by scintillation pulse has poor adaptability in relation to the different detectors.
    Most of the methods that obtain scintillation pulse information for the purpose of obtaining scintillation pulse are based on the analog-to-digital converter (referred to as ADC). And because the rise time of the scintillation pulse is normally between 1ns and 10ns, and the decline time constant is usually between 10ns and 300ns (depending on the type of detector), it is necessary that the sample speed of the ADC is greater than 1GHz for the purpose of acceptable time resolution and the sample speed of the ADC must be greater than 200MHz for the purposes of acceptable energy resolution and space resolution. Likewise, the high sampling rate of the ADC requires a high processing speed and a high transmission bandwidth, which makes the design of the data collection system difficult. In the existing digital scintillation pulse data acquisition system, analog circuits for filtering and modeling are still needed to convert a high speed scintillation pulse into a low speed signal and sampling is performed using a low speed ADC. Therefore, a fully digital data acquisition system based on ADC for flicker pulse sampling cannot be achieved by existing technologies.
    Currently, a gamma photon detection method and device (US7199370B2) is provided. Energy, peak time and a decline time constant can be obtained by using this method without an ADC. In this method, two reference voltages are previously established: I'e lz with Vt <V ,, the time difference of ttJ between the time when the impulse decline limit voltage is V and the time when the limit decline voltage of the pulse impulse is V, it is measured and the decline time constant T of the scintillation pulse can be calculated by the formula:
    Are. then, two reference voltages previously established - I7 *, and Vt, the time period of tk during 0 which the amplitude of the pulse voltage is greater than Vk and the time period tt during 0 when the amplitude of the pulse voltage is greater than Vt are measured and the amplitude of peak V of the scintillation pulse can be calculated by the formula;
    where s = V1 / Vk-1, and Vp can represent a relative value of the pulse energy. A reference voltage Vm is then previously established, the time period tml between the time the pulse rise limit voltage is of and the time the pulse rise limit voltage is of is measured and the peak moment tp of the flicker pulse can be calculated by the formula:

    However, this method has the following three disadvantages: (1) the time measured in the method is a period of time between two points in an impulse, 0 which is not the absolute time of the two points; therefore, the peak moment tp of the pulse obtained in the method represents only the relative time of the entire pulse, that is, in which period of the pulse the peak occurs, instead of representing the absolute time in which the peak occurs, (2) the information on the position of the scintillation pulse cannot be obtained in the method, (3) the energy of the pulse is obtained with a large error considering that only two voltages are used to acquire the energy of the pulse in the method. In view of the above, a digital scintillation pulse data acquisition system cannot be achieved by using the method independently.
    A new sampling method, which is an MVT sampling method based on a time sampling principle, is proposed by Qingguo Xie etc. in 2005. In MVT sampling, the time is presented with a certain sampling voltage to obtain a sampling point, different from the ADC sampling, in which the voltage is presented with a certain sampling time.
    When sampling to the rising limit of the scintillation pulse using the MVT sampling method and performing a linear adjustment of the sampling points obtained, it is possible to obtain the information time (Qingguo Xie, Chien-Min Kao, Xi Wang , Ning Guo, Caigang Zhu, Henry Frisch, William W. Moses and Chin-Tu Chen, “Potentials of Digitally Sampling Scintillation Pulses in Timing Determination in PET,” IEEE Trans. Nucl. Sci., Vol 56, Issue 5, pp. 2607-2613, 2009) and energy information in a given variation of the energy spectrum (H. Kim, C. Kao, Q. Xie, C. Chen, L Zhou, F. Tang, H. Frisch, W. Moses, W. Choong, “A multi-threshold sampling method for tof-pet signal processing," Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Vol. 602, Issue 2, pp. 618-621, 2009) of the original impulse, however, in the two published methods, the number of voltage limits is small, the established method is simple if the sampling points are used for calculation, thus giving rise to an obvious deviation, which implies that the scintillation pulse across the entire variation of the energy spectrum cannot be accurately measured with finite voltage limits, especially when the amplitude of the flicker impulse is small. The position information of the scintillation pulse should be obtained by dividing a scintillation pulse with a normal amplitude into four scintillation pulses (angular signals) with different sizes using a resistance network and comparing the proportions of the amplitudes (energy) of the four scintillation pulses; however, the position information of the scintillation pulse cannot be acquired when using the two published methods, taking into account that all amplitudes of the four pulses are small.
    A typical wave of the scintillation pulse is shown in Figure 1 and the wave includes a rising limit that increases rapidly and a declining limit that falls slowly. The increasing speed of the rising limit depends on the scintillation crystal and the photoelectric conversion device and the decreasing speed of the decline limit depends on the characteristic of the scintillation crystal.
    Regardless of the noise, the flicker pulse model can be expressed in multiple forms. Typically, the simple flicker pulse is considered to be an ideal signal model, including a linearly rising rise limit and an exponentially falling decline limit. The wave of the ideal scintillation pulse is represented in Figure 2 and the wave model is expressed as equation (1):
    (1) where LineK is the slope of the straight line of the climb limit and LineK> 0, LineB is the intercept of the climb limit, which can be an arbitrary value and which has a linear relationship with the start time of the limit ascent, ExpK is a constant of the decline time and ExpK <0, the ExpB parameter can be an arbitrary value and has a linear relationship with the start time of the decline limit and tp is the peak impulse time. Therefore, an optimal flicker pulse is expressed by four parameters LineK, LineB, ExpK and ExpB. The information, such as the start time, the peak time, the peak amplitude, the energy and the declining constant of the scintillation pulse signal can be calculated from these four parameters using the following formulas: impulse start r0
    (2) (b) the peak time tp, an approximate solution can be obtained by solving equation (3), LineKx t + LineB = exp (ExpKx t + ExpB) (3) (c) the peak amplitude Vp Vp = LineKxtp + LineB (4) (d) the energy E
    (5) (e) the position P (X, Y)
    (6) where E1, E2, E3 and E4, are respectively energy values of the four angular signals that form the impulse, and (f) the declining constant t
    (7) SUMMARY OF THE INVENTION
    An object of the invention is to present a method for digitally obtaining information by flickering pulse. In the method, the scintillation pulse is processed as a sample using voltage limits and a high precision timer, the appropriate sampling points are selected to reconstruct the scintillation pulse wave and information such as time information, information is acquired energy, position information and time decline of the original impulse. In the method, the flicker pulse data can be digitally acquired and processed independently of a complete analog circuit, which increases the stability of the system that obtains flicker pulse data and the adaptability to different types of detectors. A device for implementing the method is also presented in the present invention.
    The method for digitally obtaining scintillation pulse information presented by the present invention includes the following steps: (1) setting multiple voltage limits according to the characteristic of the scintillation pulse, (2) collecting the time the voltage of the scintillation increases and falls for each of the voltage limits, where each moment and the respective voltage limit form a sampling point. (3) selection of appropriate sampling points according to the number of voltage limits triggered and reconstruction of a scintillation pulse wave using the sampling points, and (4) acquisition of information, such as time information, energy information, position information and the decline time constant of the original scintillation pulse of the reconstructed scintillation pulse wave.
    A device for digitally obtaining scintillation pulse information provided by the present invention includes a voltage limit setting module, a time sampling module, a pulse reconstruction module and an information acquisition module, the voltage limit establishment is connected to a final detector as an analog interface and with the ability to define amplitude for each voltage limit according to the characteristics of the pulse generated by the detector. the time sampling module acquires the time when the voltage of the scintillation pulse increases for each voltage limit and the time when the pulse voltage falls for each voltage limit and transmits a sampling point consisting of the time and its limit of voltage for the impulse reconstruction module, the impulse reconstruction module reconstructs the original impulse wave using the sampling point according to an impulse model, and the information acquisition module, such as time information , energy information, position information, constant time of decline of the original pulse using the reconstructed pulse wave.
    In the method for digitally obtaining scintillation pulse information according to the present invention, multiple voltage limits are first established according to the characteristic of the scintillation pulse detected, the time at which the voltage of the scintillation pulse increases or falls to each voltage limit is accurately measured, where the measured time and the respective voltage limit form a sampling point, appropriate sampling points are selected according to the number of voltage limits triggered by the scintillation pulse, the scintillation pulse The original points are reconstructed using the sampling points according to the scintillation pulse model and the information, such as time information, energy information, position information and the decline time constant of the original pulse, are acquired from the waveform. reconstructed flicker impulse. According to the method, it is possible to obtain the fully digital scintillation pulse data processing and acquisition system, which increases the stability of the system that obtains scintillation pulse data and the adaptability to different types of detectors. A device for implementing the method is also presented in the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
    Figure 1 is a typical sign of a flicker pulse.
    Figure 2 is an ideal scintillation pulse model.
    Figure 3 is a flow chart of a method for scintillation pulse information according to the present invention.
    Figure 4 is a diagram of the system structure of a scintillation pulse information device according to the present invention.
    Figure 5 is a histogram of a timely distribution obtained by the present invention.
    Figure 6 is an energy spectrum histogram obtained by the present invention.
    Figure 7 is a position profile obtained by the present invention.
    Figure 8 is a histogram of a decline constant for a scintillation pulse obtained by the present invention. DETAILED DESCRIPTION OF THE INVENTION
    The technical solutions of the present invention are described below in detail together with the accompanying drawings and designs.
    As shown in Figure 3, a method according to the present invention includes the following steps (1) to (4). (1) Establish at least three voltage limits according to the characteristic of the scintillation pulse, which includes the following steps (1.1) to (1.2). (1. (1) Acquire the characteristic of the scintillation impulse, which obtains an average peak amplitude of the peak of the scintillation impulse in a given variation of the energy spectrum. The variation of the energy spectrum is established according to the energy of the 15 target scintillation pulse based on experience and typically does not exceed -40% to + 40% of the energy of the target scintillation pulse. (1. (2) Establish amplitudes of at least the three voltage limits according to Peak mean peak amplitude of the scintillation pulse The highest voltage limit is normally set to not higher than Pico and not less than Pico 0.7, and the lower limit 20 is usually set to not higher than Pico 0.1 and not less than 0. The number of voltage limits between Pico 0.1 and Pico 0.6 is not less than 1. The number of voltage limits is not less than 3 and the number of voltage limits does not normally have an upper limit The other voltage limits can be set at which Any position between the lowest voltage limit and the highest voltage limit. (2) Record the time when the impulse rise limit increases for each of the voltage limits and the time when the impulse decline limit falls for each of the voltage limits and each time and the respective voltage limit form a sampling point.
    The time t in which the voltage of the scintillation pulse passes through the voltage limit V (ie, 30 triggers the voltage limit V) is recorded, t is one-dimensional data throughout the detection process. The accuracy of the t count is not more than 1 ns and the error is less than 500ps. For a limit Vb the time th in which the voltage of the scintillation pulse increases to V, and the time t | 2 in which the voltage of the scintillation pulse decreases to V, are recorded, so that two sampling points of time Sn (V1, tu) and Si2 (Vhte) from the impulse to the V limit are obtained, which correspond to a rising limit sampling point and a declining limit sampling point respectively. (1. (3) provide appropriate sampling points as reconstruction and reconstruction sampling points for the scintillation pulse wave according to a scintillation pulse model, which includes the following steps (3.1) to (3.4). ( 3. (1) Select the sampling points generated by at least two voltage limits between the highest and the lowest of the triggered voltage limits as well as the reconstruction sampling points in a case where the N number of the limits of stress triggered by the impulse is greater than three, in which it is intended to select more sampling points as reconstruction sampling points and to select the sampling points generated by all the stress limits triggered as reconstruction sampling points in a case where the number N of the voltage limits triggered by the pulse is not more than three. (3. (2) Perform a linear adjustment on the reconstruction sampling points generated by the scintillation pulse rise limit according to the following equation to obtain parameters for the reconstruction of the climb limit LineKand LineB y (x) = LineK xx + LineB (1) where LineK is the slope of the straight line of the climb limit and LineK> 0 , LineB is the intercept of the rise limit and can be an arbitrary value, x is the time obtained by sampling time and> (x) is the voltage limit that corresponds to time x.In the method, the rise limit of the impulse can be reconstructed according to the flicker pulse model. (3. (3) Perform an exponential adjustment on the reconstruction sampling points generated by the scintillation impulse decline limit according to the following equation to obtain the reconstruction parameters of the ExpK and ExpB decline limit for reconstruction: y (x) = exp (ExpKx x + ExpB) (2) where ExpK is a declining time constant and ExpK <0, the ExpB parameter can be an arbitrary value, x is the time obtained by sampling time and j (x) is the voltage limit corresponding to time x. In the method, the pulse decline limit can also be reconstructed according to another scintillation pulse model. (3. (4) Obtain four parameters LineK, LineB, ExpK and ExpB for reconstruction of the impulse wave. (3. (5) uirir information, such as time information, energy information, position information and the original pulse decline time constant from the reconstructed scintillation pulse wave, which includes the following steps (4.1) to (4.4). (4. (1) Acquire the time of impulse t0
    (3) (4. (2) Acquire energy from impulse E
    (4) (4. (3) Acquire the position of the P (X, Y) impulse
    (5) where Ex, £ '2, £ 3 and £' 4 are respectively energy values of four angular signals that form the impulse. (4. (4) Acquire the time constant for the decline of impulse t
    (6)
    Figure 5 is a diagram of a result that adapts to a time resolution obtained by acquiring time information from the scintillation pulse using the method proposed by the present invention. Figure 6 is a diagram of a result of a gamma photon energy resolution obtained by acquiring energy information from the scintillation pulse using the method proposed by the present invention. Figure 7 is a diagram of a result of a position spectrum of the PET detector obtained by acquiring position information from the scintillation pulse using the method proposed by the present invention. Figure 8 is a diagram of a result of a distribution of the scintillation pulse decline time constant using the method proposed by the present invention.
    A system structure diagram of a device for obtaining flicker pulse information according to the present invention is shown in Figure 4. The device includes a limit sampling model 100, a time sampling module 200, a reconstruction module pulse 300 and an information gathering pulse 400.
    The voltage limit setting module 100 is adapted to define at least three voltage limits separated from each other according to the characteristic of the scintillation pulse, to generate a trigger signal when the voltage of the scintillation pulse increases to each of the voltage limits and when the voltage of the scintillation pulse falls to each of the voltage limits and transmits the trigger signal to the time sampling module 200.
    The voltage limit setting module includes two sub-modules: a voltage setting module 110 and a discriminating module 120. The voltage setting module 110 is adapted to establish at least three voltage limits automatically or manually. according to the characteristic of the flicker pulse. The discriminator module 120 is adapted to generate the trigger signal immediately when the scintillation pulse rise limit increases for each 5 of the voltage limits and when the scintillation pulse decline limit falls for each of the voltage limits and transmits the trigger signal to the time sampling module 200.
    In the voltage setting module 110 above, the number of voltage limits is not less than 3. The voltage number is intended to be higher, but this is also limited by factors such as cost and difficulty in engineering development . The value of each voltage limit is established according to the experience of the average peak amplitude of the scintillation pulse. The highest voltage limit is normally set to not higher than Pico and not less than Pico 0.7, and the lower voltage limit is usually set to not higher than Pico 0.1 Peak and 15 not less than 0. O number of voltage limits between Pico 0.1 and Pico 0.6 is not less than 1 and other voltage limits can be established in any position between the highest and the lowest voltage limit.
    The time sampling module 200 is adapted to measure the time when the voltage limit setting module 100 generates the trigger signal 20, in which the measured time and the respective voltage limit were a sampling point and transmit the sampling point obtained for the impulse reconstruction module 300.
    The pulse reconstruction module 300 selects the reconstruction sampling points from the sampling points obtained in the 25 time sampling module 200, reconstructs the flicker pulse wave according to a pulse module and transmits the wave as a parameter for the information acquisition module 400.
    The pulse reconstruction module 300 includes a sampling point selection module 310 and an adjustment reconstruction module 320.
    The sampling point selection module 310 is adapted to select appropriate sampling points according to the number of voltage limits used to generate the trigger signal and to transmit the appropriate sampling points to the reconstruction module. setting 320.
    The sampling point selection module 310 above selects the appropriate sampling points according to the number of voltage limits used to generate the trigger signal, which includes selecting the sampling points generated by at least two limits between the highest and the lowest of the triggered stress limits such as the reconstruction sampling points in a case where the number N of the stress limits triggered by the pulse is greater than three, and select the sampling points generated by all voltage limits triggered as the reconstruction sampling points in a case where the number N of the voltage limits triggered by the pulse is not more than three.
    The adjustment reconstruction module 320 is adapted to perform the following steps (a) to (c). (a) Perform a linear adjustment on the reconstruction sampling points generated by the scintillation pulse rise limit according to the following equation to obtain LineK and LineB rise limit reconstruction parameters: y (x) = LineKx x + LineB (1) where LineK is the straight line slope of the climb limit and LineK> 0, LineB is the intercept of the climb limit and can be an arbitrary value, x is the time obtained by sampling time and> (x) is the voltage limit that corresponds to time x. The module can also reconstruct the impulse rise limit according to the flicker pulse model. (b) Perform an exponential adjustment on the reconstruction sampling points generated by the decline limit of the scintillation pulse according to the following equation to obtain the reconstruction parameters of the ExpK and ExpB decline limit for reconstruction: y (x) = exp (ExpKxx + ExpB) (2) where ExpK is a decline time constant and ExpK <0, ExpB can be an arbitrary value, x is the time obtained by sampling time and y (x) is the voltage limit which corresponds to time x. The module can also reconstruct the impulse decline limit according to the flicker pulse model. (c) transmit the four parameters LineK, LineB, ExpK and ExpB to the 400 information acquisition model.
    The information acquisition model 400 is adapted to collect information, such as time information, energy information, position information, the original pulse decline time constant using the four LineK pulse wave reconstruction parameters , LineB, ExpK and ExpB obtained from the impulse reconstruction module 300.
    The information acquisition module 400 includes four sub-modules, a pulse time information acquisition module 410, a pulse energy information acquisition module 420, a pulse position information acquisition module 430 and a Acquisition module of pulse decline 440 440. The time information acquisition module of pulse 410 is adapted to obtain the original pulse time information from the reconstructed wave. The pulse energy information acquisition module 420 is adapted to obtain the energy information of the original pulse from the reconstructed wave. The pulse position information acquisition module 430 is adapted to obtain the position information of the original pulse from the reconstructed pulse. The impulse decline constant acquisition module 440 is adapted to obtain the information of the original pulse decline time constant from the reconstructed wave.
    The impulse time information acquisition module 410 acquires the pulse time by: the pulse time t0
    (3)
    The impulse time information acquisition module 420 acquires the energy of the pulse by: energy E
    (4)
    The pulse position information acquisition module 430 acquires the pulse position by: pulse position P (X, Y)
    (5) where Et, E2, E3 and E4 are respectively energy values of four angular signals that form the impulse.
    The impulse decline constant acquisition module 440 acquires the pulse decline time constant by; declining constant
    (6)
    The method and device of the present invention can be applied to various high energy particle detection systems and high-scale nuclear medical imaging equipment, such as a positron emission tomography (PET) system, a computerized tomography system. single photon emission (SPECT) and a computerized tomography (CT) system.
    The present invention is not limited to the above-mentioned embodiments. Those skilled in the art will be able to implement the present invention using other embodiments in accordance with the present disclosure. Therefore, any design with minor changes or modifications, according to the structure and concept of the design of the present invention, falls within the scope of protection of the present invention.
    The method and device for obtaining scintillation pulse information proposed by the present invention relates to some parameters. These parameters need to be adjusted for specific processing data in order to obtain good performance. The processing data parameters of the present invention are indicated here. in Step (1.1), the digital input pulse is a scintillation pulse obtained by using a 10x10 LYSO type crystal and a Hamamatsu R8900 PMT, the typical waveform is as shown in Figure 1, the sample rate is 10GSps and four angular signals are collected, the variation of the high energy photon and the energy spectrum varies from 500KeV to 550KeV (the energy of the target scintillation pulse is 51lKeV) and generates a pulse with an average peak of approximately 300mV, and average time of the rising limit of approximately 5ns and the detector decline time constant of 47 ns. in Step (1.2), other voltage limits are established and the amplitudes of the voltage limits are 23mV, 63mV, 135mV and 239mV, respectively. in Step (2.1), the counting accuracy is 160ps and the error is 160ps.
    权利要求:
    Claims (9)
    [0001]
    1. Method for obtaining scintillation pulse information, characterized by comprising: (1) obtaining an average peak value of a scintillation pulse in a given range of the energy spectrum and defining at least three threshold voltages according to the value peak, (2) determining the time at which the scintillation pulse voltage increases or decreases for each of the threshold voltages, in which time and its corresponding threshold voltage form a sampling point, (3) selecting a plurality of points sampling points as reconstruction sampling points and reconstruct the pulse line shape, and (4) acquire original scintillation pulse data using the reconstructed pulse line shape, in which when defining the threshold voltages in step (1), (1.1) the highest of the limit voltages is not greater than the peak value and is not less than 0.7 times the peak value, (1.2) the lowest of the limit voltages is not greater than 0.1 times the value of peak and is not less than 0, and (1.3) there is at least one t limit limit which is between 0.1 times the peak value and 0.6 times the peak value.
    [0002]
    2. Method for obtaining information on scintillation pulses, according to claim 1, characterized in that, when selecting the reconstruction sampling points in step (3), in a case where the number N of the threshold voltages triggered by the pulse is greater than three, the sampling points generated by at least two threshold voltages between the highest and the lowest of the triggered threshold voltages are selected as reconstruction sampling points and, in the case where the number N of the pulse-triggered threshold voltages does not exceed three, the sampling points generated by all triggered threshold voltages are selected as reconstruction sampling points.
    [0003]
    3. Method for obtaining scintillation pulse information according to claim 1 or 2, characterized in that the line shape of the reconstruction pulse comprises (a) reconstruction of a rising edge of the scintillation pulse using the reconstruction sampling points generated by a rising edge of the pulse according to a scintillation pulse model, and (b) reconstruction of a falling edge of the scintillation pulse, using the reconstruction sampling points generated by a falling edge of the pulse, according to the flicker pulse model.
    [0004]
    Method for obtaining scintillation pulse information according to any of claims 1 to 3, characterized in that the scintillation pulse data in step (4) comprises time information, energy information, position information and a decay time constant, where the time information is the moment when a rising edge of the reconstructed pulse line shape intersects a zero level, the energy information is obtained through digital integration in the reconstructed pulse line shape , position information is obtained by acquiring and comparing energy for each of the reconstructed line shapes of four angular pulses, and the decay time constant is obtained by calculating a decay exponent of a falling edge of the reconstructed pulse line shape.
    [0005]
    5. Device for obtaining information about scintillation pulses, characterized by comprising a limit voltage configuration module (100), connected to a front detector as an analog interface and adapted to define at least three limit voltages according to a value peak mean of a scintillation pulse in a given range of the energy spectrum, a time sampling module (200), adapted to acquire the time when the voltages of a rising edge and a falling edge of the scintillation pulse reach each one of the threshold voltages and form a plurality of sampling points, where each of the sampling points consists of a time and its corresponding limit voltage, a pulse reconstruction module (300), adapted to select some sampling points from the plurality of sampling points formed in the time sampling module (200) as reconstruction sampling points and reconstructing the line shape of the scintillation pulse action according to a pulse model; and an information acquisition module (400), adapted to acquire pulse data from an original scintillation pulse according to the line shape of the reconstructed scintillation pulse.
    [0006]
    6. Device according to claim 5, characterized in that the threshold voltage adjustment module (100) comprises a voltage adjustment module (110) and a discriminator module (120), the voltage adjustment module (110) is adapted to define the threshold voltages according to the peak value of the scintillation pulse in a certain range of the energy spectrum, and the discriminator module (120) is adapted to compare the voltage of the scintillation pulse with the threshold voltage and generate a signal trigger when the flicker pulse voltage reaches the threshold voltage.
    [0007]
    Device according to claim 5 or 6, characterized in that the pulse reconstruction module (300) comprises a sample point selection module (310) and a plug-in reconstruction module (320), wherein the module sampling point selection (310) is adapted to select appropriate sampling points according to the number of threshold voltages used to generate the trigger signal and transmit the appropriate sampling points to the plug-in reconstruction module (320), and the plug-in reconstruction module (320) is adapted to reconstruct the scintillation pulse model, which comprises: (a) reconstructing, according to the scintillation pulse model, a rising edge of the scintillation pulse, using the reconstruction sampling generated by a rising edge of the pulse, and (b) reconstructing, according to the scintillation pulse model, a descending edge of the scintillation pulse, using the reconstruction sampling points generated by a descending edge of the wrist.
    [0008]
    8. Device, according to claim 7, characterized by the fact that, for the sampling point selection module (320), adapted to select the reconstruction sampling points, in a case where the number N of the voltages thresholds triggered by the pulse is greater than three, the sampling points generated by at least two threshold voltages between the highest and the lowest of the triggered threshold voltages are selected as reconstruction sampling points and, in the case where the number N of the threshold pulse-triggered voltages does not exceed three, the sampling points generated by all triggered threshold voltages are selected as reconstruction sampling points.
    [0009]
    9. Device according to any one of claims 5 to 8, characterized in that the information acquisition module (400) comprises a pulse time information acquisition module (410), an information acquisition module pulse energy (420), pulse position information acquiring module (430) and a pulse decay time constant acquisition module (440), in which the pulse time information acquisition module (410) is adapted to obtain time information from the original scintillation pulse, reconstructing the line shape of the scintillation pulse, the pulse energy information acquisition module (420) is adapted to acquire energy information from the original scintillation pulse, reconstructing the scintillation pulse waveform, the pulse position information acquisition module (430) is adapted to acquire position information from the original scintillation pulse, reconstructing the scintillation pulse waveform and the pulse decay time constant acquisition module (440) is adapted to acquire a decay time constant from the original scintillation pulse, reconstructing the line shape of the scintillation pulse.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112013026944B1|2020-09-29|METHOD AND DEVICE FOR EXTRACTING INFORMATION BY FLASHING IMPULSE
    CN103969675B|2017-08-04|Digitize the baseline correction method and system of scintillation pulse
    CN102073059B|2013-05-22|Digital pileup waveform processing method and system
    JP6473509B2|2019-02-20|Scintillation pulse digitization method
    Dahlbom et al.1997|Performance of a YSO/LSO phoswich detector for use in a PET/SPECT system
    JP6875548B2|2021-05-26|Scintillation pulse digital signal fitting method
    CN109581461B|2020-05-12|Nuclear pulse energy measuring method and system
    Li et al.2010|A new statistics-based online baseline restorer for a high count-rate fully digital system
    WO2021135337A1|2021-07-08|Signal sampling circuit, detection apparatus, and imaging system
    CN104932000B|2017-11-28|The method and device that γ photons positional information obtains in a kind of PET device
    Ruiz-Gonzalez et al.2017|Maximum-likelihood estimation of scintillation pulse timing
    JP6336070B2|2018-06-06|Method and system for recovering scintillation pulse information
    JP2021535454A|2021-12-16|A method and device for determining a fitting model for a signal and reconstructing the signal.
    CN202177701U|2012-03-28|Device for extracting scintillation pulse information
    Ko et al.2019|Time-based signal sampling using sawtooth-shaped threshold
    Gu et al.2016|A new pulse pileup rejection method based on position shift identification
    Wei et al.2011|Influence factors of two dimensional position map on photomultiplier detector block designed by quadrant sharing technique
    Ruiz-Gonzalez et al.2015|Fisher information analysis of digital pulse timing
    Gu et al.2014|A digital pulse library for the optimization of signal processing in PET
    Yue et al.2019|An Energy-Resolved Photon-Counting Readout Electronics for Scintillator Based on Pole-Zero Compensation and ToT Method
    Xie et al.2003|A new approach for pulse processing in PET
    OA16634A|2015-12-01|Method and device for extracting scintillation pulse information
    Deng et al.2014|Event Pulse Classification with Multi-Voltage Threshold samples for scatter rejection in PET
    McElroy et al.2004|Singles list mode data processing for MADPET-II
    WO2015198207A1|2015-12-30|Method for dead time determination in a gamma camera and a system for accomplishing the same
    同族专利:
    公开号 | 公开日
    EP2700360A1|2014-02-26|
    JP5800983B2|2015-10-28|
    US9772408B2|2017-09-26|
    EP2700360A4|2014-12-17|
    CN102262238B|2014-07-23|
    JP2014516411A|2014-07-10|
    BR112013026944A2|2017-01-10|
    US20140052414A1|2014-02-20|
    CN102262238A|2011-11-30|
    WO2012142778A1|2012-10-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    JPS59180478A|1983-03-31|1984-10-13|Shimadzu Corp|Scintillation camera|
    US4544961A|1983-09-01|1985-10-01|Sperry Corporation|Triplex digital magnetic recording and reproducing system|
    JP3697340B2|1997-11-07|2005-09-21|独立行政法人放射線医学総合研究所|Method for specifying emission position of radiation incident position 3D detector|
    JP2002022846A|2000-07-05|2002-01-23|Seiko Instruments Inc|Energy dispersive x-ray analyzer|
    JP3950964B2|2003-01-23|2007-08-01|独立行政法人放射線医学総合研究所|Actuated radiation position detector in strong magnetic field|
    JP2005064132A|2003-08-08|2005-03-10|Matsushita Electric Ind Co Ltd|Circuit and method for driving laser diode|
    TWI313758B|2004-04-02|2009-08-21|Nat Health Research Institutes|A device and method for characterizing energy,peak time and decay time constant of gamma ray|
    JP2006224174A|2005-02-21|2006-08-31|Sumitomo Heavy Ind Ltd|Laser machining apparatus, and method for setting threshold of pulse energy|
    JP4611106B2|2005-03-11|2011-01-12|住友重機械工業株式会社|Radiation detection circuit and radiation inspection apparatus|
    US8164063B2|2006-07-28|2012-04-24|Koninklijke Philips Electronics N.V.|Time of flight measurements in positron emission tomography|
    CN101143097B|2006-09-11|2010-04-14|住友重机械工业株式会社|Radiation ray detecting circuit and radiation ray detecting device|
    JP4758943B2|2007-05-10|2011-08-31|日立アロカメディカル株式会社|Radiation measurement equipment|
    CN101377548B|2008-09-29|2012-05-23|南华大学|Method and apparatus for rebuilding and measuring 222Rn and 220Rn horizontal alpha energy spectrum in air|
    CN202177701U|2011-04-19|2012-03-28|苏州瑞派宁科技有限公司|Device for extracting scintillation pulse information|CN102843139B|2012-09-20|2015-10-28|苏州瑞派宁科技有限公司|A kind of scintillation pulse method for digitizing and device|
    CN103054604B|2012-12-25|2015-04-01|沈阳东软派斯通医疗系统有限公司|Method and device for converting energy information and position information of positron emission tomographysystem and PET system|
    CN103969675B|2013-02-05|2017-08-04|苏州瑞派宁科技有限公司|Digitize the baseline correction method and system of scintillation pulse|
    CN104337531B|2013-07-25|2016-12-28|苏州瑞派宁科技有限公司|Method and system are met at heat input for digital PET system|
    CN103607205B|2013-11-12|2017-02-08|沈阳东软医疗系统有限公司|Signal processing method, apparatus and equipment|
    CN104639123B|2013-11-14|2017-08-25|苏州瑞派宁科技有限公司|The time point acquisition methods and device of threshold value are crossed in scintillation pulse|
    CN104656119B|2013-11-19|2018-06-05|苏州瑞派宁科技有限公司|The method and system that a kind of scintillation pulse information restores|
    CN105204060B|2014-06-19|2018-06-08|苏州瑞派宁科技有限公司|Radiation detection, measurement, identification, the timing means of imaging system and method|
    CN105824817B|2015-01-05|2019-05-21|苏州瑞派宁科技有限公司|A kind of digitizing solution of scintillation pulse|
    CN104599302B|2015-01-13|2017-06-06|上海联影医疗科技有限公司|The method for obtaining PET crystal energies peak value and setting energy frequency discriminator|
    CN104939859A|2015-06-23|2015-09-30|李彬|Method for correcting CT image|
    CN105212954B|2015-11-05|2018-03-16|苏州瑞派宁科技有限公司|A kind of pulse pile-up event real-time processing method and system|
    CN105842544B|2016-03-18|2018-09-18|南京瑞派宁信息科技有限公司|A kind of the scintillation pulse time label and its cross validation method of iteration|
    CN106125127B|2016-06-18|2018-12-04|武汉京邦科技有限公司|A kind of the time labeling method and its infinitesimal array code system of silicon photoelectric multiplier|
    CN106443760B|2016-09-14|2019-02-12|湖北锐世数字医学影像科技有限公司|A kind of method of scintillation pulse simplified model, reconstruction and energy harvesting|
    CN107024711B|2017-04-17|2019-02-26|苏州瑞派宁科技有限公司|A kind of approximating method of scintillation pulse digitized signal|
    JP2019007810A|2017-06-23|2019-01-17|浜松ホトニクス株式会社|Radiation detector|
    CN108968999A|2018-08-10|2018-12-11|上海联影医疗科技有限公司|Detector time discriminating method, detector and medical imaging devices|
    CN109350098B|2018-08-27|2021-02-26|苏州瑞派宁科技有限公司|Method for determining fitting mode of signal, method for reconstructing signal and device|
    CN109171787B|2018-08-27|2021-02-26|苏州瑞派宁科技有限公司|Method and device for sampling pulse signal and computer program medium|
    CN110031860B|2019-04-03|2021-04-02|维沃移动通信有限公司|Laser ranging method and device and mobile terminal|
    CN111158039B|2020-01-02|2022-01-04|苏州瑞派宁科技有限公司|Signal sampling and reconstruction method and device|
    CN111307304B|2020-03-09|2021-09-07|上海航天计算机技术研究所|Infrared bell-shaped pulse characteristic parameter extraction and verification method and platform|
    WO2021220657A1|2020-04-27|2021-11-04|株式会社堀場製作所|Signal processing method, learning model generation method, signal processing device, radiation detection device, and computer program|
    CN112022186A|2020-08-13|2020-12-04|南昌大学|Special PETsystem and imaging method for novel coronavirus|
    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-12-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-07-21| B09A| Decision: intention to grant|
    2020-09-29| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/05/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    CN201110097421.7|2011-04-19|
    CN201110097421.7A|CN102262238B|2011-04-19|2011-04-19|Method and device for extracting scintillation pulse information|
    PCT/CN2011/073856|WO2012142778A1|2011-04-19|2011-05-10|Method and device for extracting scintillation pulse information|
    [返回顶部]