medication injection pens

专利摘要:
DISPOSABLE INJECTION PEN FOR MULTIPLE USES. It is a medication injection pen (51) that includes a housing (1) and a dose adjustment knob (2) having at least one internal tooth (22). A braking member (5) has a plurality of axially extending ribs (52). A trigger or recoil member (9) includes at least one external tooth (92) engaging at least one internal tooth (22) of the dose adjustment knob (2) and at least one ratchet arm (96) engaging the plurality of ribs extending axially (52). The trigger (9) is prevented from rotating with the dose adjustment knob (2) while moving axially with the dose adjustment knob (2) during dose adjustment and dose correction, and the trigger (9) rotates with the dose adjustment knob (2) during an injection.
公开号:BR112013023732B1
申请号:R112013023732-5
申请日:2012-03-15
公开日:2021-03-16
发明作者:Michael Quinn；Richard Cronenberg
申请人:Becton, Dickinson And Company；
IPC主号:

专利说明:

RELATED REQUESTS
[001] This application claims the benefit under Title 35 of the United States Code § 119 (e) of US Provisional Patent Application with Serial Number 61 / 457,391, filed on March 16, 2011, and is hereby incorporated in its entirety as a reference. FIELD OF THE INVENTION
[002] The invention relates to a pen-type injection device for multiple uses with improved functionality, including an improved dose-adjusted reverse dial, and an improved last-dose control to prevent a dose from being adjusted greater than the amount of drug remaining in a medication cartridge. BACKGROUND OF THE INVENTION
[003] Various medication injection pen devices are known in the prior art. These prior art devices occasionally include features to allow a user to correct a dose that has been adjusted too large, which can be referred to as “reverse dialing”. Another feature that may be provided by some of the prior art devices is the ability to control a final dose of a medication cartridge so that a user cannot adjust a dose greater than the amount of medication remaining in the cartridge. This feature is referred to as last dose control or last dose management. Both features are desired by the users of such pen devices; however, prior art devices do not satisfactorily satisfy these needs. Many of the prior art devices can provide one of these features, but not both. In addition, many of the devices in the previous one require additional steps to perform a reverse dial, which are inconvenient and not intuitive to the user. Therefore, there is a need in the art to provide improved functionality of reverse dial mechanisms and last dose control together in a medication injection pen. SUMMARY OF THE MODALITIES OF THE INVENTION
[004] The exemplary embodiments of the present invention address at least one of the above problems and / or disadvantages and provide at least the advantages described below.
[005] In accordance with an exemplary embodiment of the present invention, a medication injection pen includes a housing and a rotary dose adjustment knob having at least one internal tooth. A brake member has a plurality of splines extending axially. A driver includes at least one external tooth engaging at least one internal tooth of the rotary dose adjustment knob and at least one ratchet arm engaging the plurality of splines extending axially. The trigger is prevented from rotating in relation to the dose adjustment dial while moving axially to the dose adjustment dial during dose adjustment and dose correction, and the trigger rotates next to the adjustment dial dose during an injection.
[006] According to another exemplary embodiment of the present invention, a medication injection pen includes a housing and a rotary dose adjustment button that serves to adjust and correct a dose. A brake member is axially and rotationally fixed to the housing. A trigger moves axially next to the dose adjustment dial when adjusting and correcting the dose, and moves rotationally next to the dose adjustment dial when injecting the adjusted dose. A hollow plunger rod moves axially when injecting the adjusted dose. A brake core member is disposed within the hollow piston rod to substantially prevent rotational movement of the hollow piston rod.
[007] Objectives, advantages and additional salient features of the exemplary modalities of the invention will become apparent to individuals skilled in the art from the detailed description below, which, taken in conjunction with the attached drawings, reveals the exemplary modalities of the invention. BRIEF DESCRIPTION OF THE DRAWINGS
[008] These and other features and advantages exemplifying certain exemplary modalities of the present invention will become more apparent from the following description of certain exemplary modalities of this when taken in conjunction with the attached drawings, in which: Figure 1 it is a perspective view of a first exemplary embodiment of an injection pen according to the present invention; Figure 2A is a perspective view of the injection pen of Figure 1 with a lower body of the pen removed; Figure 2B is an exploded view of the injection pen of Figure 1; Figure 2C is a perspective view in partial section of the upper body of the pen of Figure 2B; Figure 3 is a cross-sectional elevation view of the injection pen of Figure 2A; Figure 4 is a perspective view of a rotary dose adjustment knob in Figure 3; Figure 5 is a side perspective view of an indentation member of Figure 3; Figure 6 is a perspective view of the brake tower of Figure 3; Figure 7 is a perspective view of the engagement between the brake tower and the recoil member; Figure 8 is a perspective view of a lead screw of Figure 3; Figure 9 is a front perspective view of the indentation member of Figure 5; Figure 10 is a perspective view of the engagement between the recoil member, the brake tower and a lead screw of Figure 3; Figure 11 is a cross-sectional elevation view of the coupling between the rotary dose adjustment knob, the lead screw, the recoil member and the brake tower; Figure 12 is a cross-sectional elevation view of the rotary dose adjustment knob and the recoil member in relation to the lead screw and the brake tower after adjusting a dose; Figure 13 is a perspective view of a dose interruption member that engages the Figure 3 withdrawal member; Figure 14 is a cross-sectional elevation view of the rotary dose adjustment knob; Figure 15 is a cross-sectional elevation view of the dose interruption member in an initial position; Figure 16 is a partial elevation cross-sectional view of the dose interruption member in a final position; Figure 17 is an elevation view of an indicator window arranged in an upper portion of the body of the injection pen of Figure 1; Figure 18 is an elevation view of the indicator window in Figure 17 indicating that an adjusted dose has not been fully injected; Figure 19 is a perspective view of the rotary dose adjustment knob including an indicator; Figure 20 is an exploded view of an injection pen according to a second exemplary embodiment of the present invention; Figure 21 is a cross-sectional elevation view of the injection pen of Figure 20; Figure 22 is an exploded view of an injection pen according to a third exemplary embodiment of the present invention; Figure 23 is a cross-sectional elevation view of the injection pen of Figure 22; Figure 24 is a perspective view of a brake tower core and Figure 22 brake tower; Figure 25 is a perspective view of the engagement between the brake tower core and a plunger rod of Figure 22; Figure 26 is a perspective view of a plunger rod; Figure 27 is a perspective view of the engagement between the brake tower core and the piston rod of Figure 22; Figure 28 is a cross-sectional elevation view of the coupling between the brake tower core and a lead screw of Figure 22; Figure 29 is a perspective view of an injection pen according to a fourth exemplary embodiment of the present invention; Figure 30 is an exploded view of the injection pen of Figure 29; Figure 31 is a perspective view of the brake tower of Figure 30; Figure 32 is a perspective view of a brake tower core of Figure 30; Figure 33 is a perspective view of a lead screw of Figure 30; Figure 34 is a perspective view of a plunger of Figure 30; Figure 35 is a cross-sectional elevation view of the injection pen of Figure 29; Figure 36 is a cross-sectional elevation view of the coupling between the brake tower, the brake tower core, the lead screw and the piston rod of Figure 30; Figure 37 is a cross-sectional elevation view of a plunger rod of Figure 30; Figure 38 is a perspective view of a plunger rod according to a fifth exemplary embodiment of the present invention; Figure 39 is a perspective view of a brake tower core according to the fifth exemplary embodiment of the present invention; Figure 40 is a perspective view of the engagement between the piston rod and the brake tower core of Figures 38 and 39; Figure 41 is a cross-sectional elevation view of an injection pen according to the fifth exemplary embodiment of the present invention; Figure 42 is a cross-sectional elevation view of an injection pen according to a sixth exemplary embodiment of the present invention; Figure 43 is a perspective view of a lead screw in Figure 42; Figure 44 is a cross-sectional elevation view of the lead screw of Figure 43; Figure 45 is a cross-sectional elevation view of the coupling between the brake tower core and the lead screw of Figure 42; Figure 46 is a cross-sectional elevation view of the brake tower core and lead screw assembly being inserted into a brake tower of Figure 42; Figure 47 is a cross-sectional elevation view of the lead screw before forming a snap fit connection to the brake tower; Figure 48 is an enlarged cross-sectional elevation view of the lead screw before forming the pressure fitting connection with the brake tower; Figure 49 is a cross-sectional elevation view of a press fit connection between the lead screw and the brake tower; Figure 50 is a cross-sectional elevation view of a plunger rod inserted in the brake tower assembly of Figure 49; Figure 51 is an end elevation view of the brake tower assembly of Figure 50; Figure 52 is an exploded view of an injection pen according to a seventh exemplary embodiment of the present invention; Figure 53 is a cross-sectional elevation view of the injection pen of Figure 52; Figure 54 is a perspective view of a rotary dose adjustment knob for the injection pen of Figure 52; Figure 55 is a cross-sectional elevation view of the injection pen of Figure 54; Figure 56 is a perspective view of an indentation member of the injection pen of Figure 52; Figure 57 is a cross-sectional elevation view of the recoil member of Figure 56; Figure 58 is a distal perspective view of the recoil member of Figure 56; Figure 59 is a perspective view of an injection screw lead screw of Figure 52; Figure 60 is a perspective view of a brake tower core of the injection pen of Figure 52; Figure 61 is a perspective view of an injection pen brake tower of Figure 52; Figure 62 is a cross-sectional elevation view of the brake tower of Figure 61; Figure 63 is a perspective view of a plunger rod of the Figure 52 injection pen; Figure 64 is a cross-sectional elevation view of the plunger rod of Figure 63; Figure 65 is a perspective view of an upper body of the injection pen of Figure 52; Figure 66 is a cross-sectional elevation view of the upper body of the Figure 65 pen; Figure 67 is a perspective view of a clicker body of the injection pen of Figure 52; Figure 68 is a bottom plan view of the click device body of Figure 67; Figure 69 is an elevation view of the click device body of Figure 67; Figure 70 is a top plan view of the click device body of Figure 67; Figure 71 is a proximal perspective view of the injection pen brake tower of Figure 52; Figure 72 is a perspective view of the lead screw and the brake tower core before engaging with the brake tower of the injection pen of Figure 52; Figure 73 is a perspective view of the lead screw connected to the brake tower core before being connected to the brake tower of Figure 72; Figure 74 is an elevation view of the lead screw and brake tower core connected to the brake tower of Figure 72; Figure 75 is an elevation view of the engagement between the plunger rod and the brake tower core of the Figure 52 injection pen; Figure 76 is a cross-sectional elevation view of a click device body disposed between a rotary dose adjustment button and an injection pen indentation member according to an eighth exemplary embodiment of the present invention; Figure 77 is a perspective view of the click device body of Figure 76; Figure 78 is a partial perspective view of the withdrawal member of the injection pen of Figure 76; Figure 79 is a partial perspective view of the dose adjustment knob of the injection pen of Figure 76; and Figure 80 is a cross-sectional elevation view of the Figure 76 injection pen.
[009] Throughout the drawings, it will be understood that similar numerical references refer to similar elements, resources and structures. DETAILED DESCRIPTION OF THE MODALITIES EXAMPLIFIERS
[010] The materials exemplified in this description are provided to assist in a comprehensive understanding of the exemplary modalities of the invention with reference to the attached figures. Correspondingly, those of ordinary skill in the art will recognize that various changes and modifications to the exemplary modalities described herein can be made without departing from the scope and spirit of the claimed invention. Likewise, descriptions of well-known functions and constructions will be omitted for reasons of clarity and conciseness.
[011] Figure 1 depicts a view of an injection pen 51 according to a first exemplary embodiment of the present invention. As shown, the injection pen 51 includes an upper body or pen housing 1, which houses a plurality of dose adjustment and injection components. The upper body of the pen 1 is connected to a cartridge housing 14, which houses a medication cartridge 15, as shown in Figures 2A and 2B. The injection pen 51 may also include a lower pen cap 12 to cover the cartridge 15 and the cartridge housing 14 when the injection pen is not in use. As shown, the injection pen 51 includes a dose adjustment rotary knob 2 which includes a rotary knob portion which is rotated by a user to adjust a desired dose. The rotary dose adjustment knob 2 also includes a plurality of numerals, as shown in Figure 2B, corresponding to a series of dosage units that are visible through a window 13 provided in the upper body of the pen 1. A user rotates the knob dose adjustment rotary 2 until the desired dose is visible in window 13. The upper body of the pen 1 can include an arrow or other indicator 53 to accurately indicate the adjusted dose. Once the desired dose is adjusted, a user presses button 3 until the adjusted dosage amount is completely injected. An external guard 69 (Figure 2b) can cover a needle 56 to prevent accidental needle sticks by removing the bottom cap of the pen 12.
[012] Optionally, the upper body of pen 1 can also include a second window 55 to indicate when the adjusted dose is complete, as shown in Figures 1, 2A and 2B. An indicator or marker 27, as shown in Figure 19, can be provided on the outer surface of the dose adjustment knob 2 that is visible through the second window 55 only when the dose adjustment knob 2 has returned to its initial position , thus indicating that the injection process is complete. Figure 18 describes a scenario when the dose adjustment rotary knob 2 has almost returned to its initial position. As shown, indicator 27 is not visible through window 55, so the user is notified that the injection is not complete. Once the marker 27 is visible in window 55, as shown in Figure 17, the user makes sure that the adjusted dose has been completely injected.
[013] Figure 3 describes a cross section of an injection pen 51 according to the first exemplary embodiment of the present invention. The reference to the individual components can be better understood due to the exploded assembly view shown in Figure 2B. As shown, a push button 3 is provided at a proximal end, closer to a user and further away from a needle 56, from the upper body of the pen 1. Preferably, the push button 3 comprises an annular rim or ring 57 which engages a corresponding annular groove 58 provided on the inner surface of the rotary dose adjustment knob 2. Preferably, the rim and annular groove connection is a friction fit that holds the push button 3 in a position oriented on the knob dose adjustment rotary 2 under the force of a button spring 10, but allows the pressure button 3 to be pressed on the dose adjustment rotary button 2 to inject an adjusted dose. The interior of the pushbutton 3 accommodates an indentation insert insert 8 which is located on an internal surface at a proximal end of an indentation member or actuator 9. The pushbutton 3 is designed to rotate freely in the insertion of recoil pad 8.
[014] The recoil or actuator member 9 is a cylindrical member, as shown in Figure 5, coaxial and surrounded by the rotary dose adjustment knob 2. The recoil member 9 is provided coaxially around a brake tower 5, as shown in Figure 6, which is axially and rotationally attached to the upper body of the pen 1. The brake tower 5 coaxially surrounds a plunger rod 6, as shown in Figure 3. The plunger rod 6 includes a set of keys 62 that engage an internal groove to the brake tower 5 to rotatively lock the piston rod 6 to the brake tower 5. Preferably, the piston rod 6 includes a plurality of threads 64 provided on the internal surface thereof, as shown in Figure 3 The plunger rod 6 coaxially surrounds a lead screw 4 that includes a series of threads 42 at least at its distal end, as shown in Figure 20. The lead screw threads 42 are in threaded engagement with the threads the internal ones 64 provided in the piston rod 6. As discussed later, due to its threaded engagement with the lead screw 4, the piston rod 6 is moved in the cartridge 15 during injection to press on a stop 16 provided inside the cartridge 15 in order to expel a dose of medication. A corrugated clip or spring 11, as shown in Figures 2B and 3, is provided between a distal end of the brake tower 5 and the cartridge 15 to orient the cartridge 15 in a distal direction to prevent any movements of the cartridge 15 during injection, and therefore ensure that an accurate dose is injected.
[015] To adjust a dose using the injection pen 51 of the first example mode, a user rotates the dose adjustment knob portion 2 in relation to the upper body of the pen 1. An outer surface 59 of the rotation knob Dose adjustment 2 includes a thread 23, as best shown in Figure 19, which is in threaded engagement with a plurality of threads 17 (Figure 2C) provided on the inner surface of the upper body of the pen 1, as shown in Figure 3. correspondingly, as the dose adjustment dial 2 is rotated in relation to the upper pen body 1, the dose adjustment rotary button 2 screw or advance a distance away from the upper pen body 1, as shown in Figure 3. The dose adjustment rotary knob 2 includes a shoulder or ring 21 on its inner surface near the proximal end, as shown in Figures 3 and 4. This ring 21 engages with a enlarged portion or head 91 of the recoil member 9, as shown in Figures 3 and 5. The annular shoulder 21 of the rotary dose adjustment knob 2 preferably comprises a series of teeth or grooves 22 that engage a plurality of similarly shaped teeth or grooves 92 provided in the enlarged head 91 of the recoil member 9. Preferably, the teeth of the dose adjustment rotary knob 22 and the teeth of the recoil member 92 extend in opposite axial directions. During dose adjustment, the dose adjustment rotary knob 2 is free to rotate in relation to the setback member 9 in either a clockwise or counterclockwise direction. As this occurs, the plurality of teeth or grooves 22 on the rotary dose adjustment knob 2 slides past the teeth 92 provided in the head portion 91 of the recoil member 9, thereby providing a tactile signal or click noise for indicate the adjustment of a dosage amount. As further described below, the dose adjustment rotary knob 2 is allowed to rotate in relation to the recoil member 9 during adjustment due to a unidirectional ratchet that prevents the recoil member 9 from rotating next to the dose adjustment rotary knob 2 on adjustment direction.
[016] To correct an adjusted dose that may have been set too high, the user simply rotates the dose adjustment knob 2 in the opposite direction. The rotation of the dose adjustment rotary knob 2 in this direction is not transferred to the recoil member 9 due to the unidirectional ratchet between the recoil member 9 and the brake tower 5, as shown in Figure 7. The recoil member 9 next to its distal end includes a pair of ratchet arms 96, as shown in Figure 5 and Figure 7. The pair of ratchet arms 96 engages a plurality of splines or teeth 52 provided on the outer surface of the brake tower 5, as shown in Figure 6 and Figure 7. The ratchet arms 96 and splines or teeth 52 are configured to allow relative rotation in only one direction, that is, the direction that allows the injection of an adjusted dose. The friction provided between the ratchet arms 96 and the teeth 52 on the brake tower 5 is greater than the friction between the corresponding teeth 92 and 22 on the recoil member 9 and the dose adjustment rotary knob 2, respectively. Then, the dose adjustment rotary knob 2 can be turned back to correct an adjusted dose without causing the recoil member 9 to rotate in this direction. Correspondingly, the teeth 92 and 22 provided on the recoil member 9 and the rotary dose adjustment knob 2, respectively, slide in addition to each other to provide click noise during reverse dose dialing, just as during the adjustment of normal dose, thus indicating a correction of the adjusted dose.
[017] As the dose adjustment rotary knob 2 screws or advances axially away from the upper body 1 during dose adjustment, the recoil member 9 is also induced to move axially away from the body to a corresponding distance. This axial movement is caused by the engagement between the annular shoulder 21 on the rotary dose adjustment knob 2 pressing against the enlarged head portion 91 of the recoil member 9 during its movement away from the body. Once a desired dose has been adjusted, the user presses the pressure button 3, which is attached to the recoil insert insert 8 which is axially connected to the recoil member 9. Under the force applied by the user by pressing the pressure button 3, the withdrawal member 9 is moved in a locking or coupling engagement to the dose adjustment rotary knob 2 through a coupling of the respective teeth or grooves 92 and 22 provided on the dose adjustment rotary knob 2 and the member indentation 9, respectively. As the user continues to press the push button 3, the dose adjustment rotary button 2 is induced to rotate and screw back into the upper body of the pen 1 through the threaded engagement between the thread 23 on the rotary adjustment knob dose 2 and the thread 17 on the upper body of the pen 1. The rotation of the rotary dose adjustment knob 2 is then transferred to the recoil member 9 due to its locking or coupling engagement. The force of the user pressing the button 3 is sufficient to overcome the friction between the ratchet arms 96 on the recoil member 9 and the teeth or splines 652 on the brake tower 5. As a result, the recoil member 9 is allowed to rotate in this direction . As the recoil member 9 rotates relative to the brake tower 5 during injection, the ratchet arms 96 produce a tactile signal or click noise as the ratchet passes through teeth 52 in the brake tower 5. This indicates to the user that the injection of the adjusted dose is taking place.
[018] The rotation of the recoil member 9, as allowed during the injection, is then transferred to the lead screw 4, which is rotatably fixed to the recoil member 9 through a keyway connection provided between the lead screw 4 and the recoil member 9. As shown in Figure 9, an internal surface 60 of the recoil member 9 includes a groove or slot 98 which is engaged with a key 48 provided at the proximal end of the lead screw 4, as shown shown in Figure 10. Preferably, the recoil member 9 includes two opposingly arranged slots 98 for engaging two opposingly arranged keys 48 provided in the lead screw 4. The recoil member 9 moves axially with respect to the lead screw 4 during dose adjustment and dose correction, through the interconnection between key 48 and slot 98 as shown in Figures 11 and 12. In one embodiment, the length of slot 98 in the recoil member 9 can be configured to c respond to a maximum dose to be injected in a single injection. The lead screw 4 is axially fixed with respect to the upper body of the pen 1 by means of a snap-fit coupling to the brake tower 5 which is fixed axially and rotationally to the upper body of the pen 1 as discussed below. As shown in Figures 8 and 11, the lead screw 4 includes a disk-like portion 44 with an angled surface 45 that allows the lead screw 4 to snap into place through a rim or set of protrusions 54 provided within the tower brake 5, as shown, thus axially locking the lead screw 4 in relation to the upper body of the pen 1.
[019] As previously described, the lead screw 4 includes a plurality of threads 42 at its distal end which are in a threaded engagement with a plurality of threads 64 preferably provided along the entire length of a hollow piston rod 6 as shown in Figure 3. The plunger rod 6 is maintained non-rotating in relation to the upper body of the pen 1 due to a non-rotating coupling to the brake tower 5, which is kept fixed axially and rotationally in relation to the upper body of the pen 1. The plunger rod 6 includes a key or set of keys 62 at its distal end that engages a slot 61 (Figure 12) provided on the inner surface of the brake tower 5 to prevent a relative rotation between them, while allows the piston rod 6 to move axially with respect to it. The threads 42 of the lead screw 4 have a flat portion 43 corresponding to a flat portion 65 of the plunger rod 6 (Figure 2b) so that axial movement of the lead screw during dose adjustment and dose correction does not result in an axial movement of the piston rod 6. Correspondingly, the rotation of the lead screw 4 during injection of a dose causes the threads 42 of the lead screw 4 to engage with the threads 64 of the piston rod 6, moving thus, axially the piston rod 6.
[020] During assembly, the brake tower 5 is inserted into the upper body of the pen 1 from the distal end. As shown in Figure 3, the upper body of the pen 1 includes a cross wall 18 that limits the movement of the brake tower 5 in the body 1 by blocking an enlarged distal portion 66 of the brake tower 5, as shown. In addition, a key projecting inwards 19 is also provided distally from the transverse wall 18 on the inner surface of the upper body of the pen 1, as shown in Figure 15. The key 19 engages a slot 55 provided in the extended distal portion 66 of the brake tower 5, as shown in Figure 6, to rotationally secure the brake tower 5 in relation to the upper body of the pen 1. Preferably, a plurality of axially extending keys 19 are arranged on the internal surface of the body upper part of the pen 1, as shown in Figure 15, to engage a plurality of slots 55 in the widened distal portion 66 of the brake tower 5.
[021] Due to the fact that the piston rod 6 is not rotatable in relation to the body 1, as the lead screw 4 is induced to rotate during the injection, as previously described due to its rotational coupling to the recoil member 9 , the plunger rod 6 through its threaded engagement with the lead screw 4 is induced to move in the distal direction to press against the stop 16 provided in the medication cartridge 15, thus expelling a liquid medication from it. A mechanical advantage is preferably provided so that the dose adjustment rotary knob 2 moves more in the axial direction than the plunger rod 6 during injection, reducing the injection force that must be applied by the user. This is preferably accomplished by providing different slopes for the threaded connection between the dose adjustment rotary knob 2 and the upper body of the pen 1 and the threaded connection between the lead screw 4 and the plunger rod 6. The reason between the threaded slopes it can vary depending on the liquid medication and the expected dose volumes. For example, the slope ratio can be 4.35: 1 or 3.25: 1, but not limited to these. The plunger rod 6 is prevented from moving in the proximal direction because the lead screw 4 is rotatable only in a single direction (which results in a distal movement of the plunger rod 6) due to the unidirectional ratchet between the recoil member 9 and the brake tower 5. Therefore, an accurate dosage can be guaranteed because the piston rod 6 keeps its engagement with the stop 16 between injections.
[022] A dose interruption member 7, as shown in Figures 2b and 13, is provided for last dose management, to avoid adjusting a dose that is greater than the remaining amount of medication in cartridge 15. The member dose interruption 7 is axially slidable, but rotationally fixed in relation to the recoil member 9 being positioned between a pair of grooves 94 provided on the outer surface of the recoil member 9. The dose interruption member 7 is a half-type element nut, as shown, which is threaded on its outer surface with a plurality of threads 72. These threads 72 are configured to engage the corresponding threads 24 provided within the dose adjustment knob 2, as shown in Figure 14. A Figure 15 describes the dose interruption member 7 in its initial position. As shown, the dose interruption member 7 is threadably engaged with one or two threads closest to the threads 24 provided on the dose adjustment rotary knob 2. During dose adjustment, as the dose adjustment rotary knob dose 2 rotates in relation to the withdrawal member 9 and therefore also in relation to the dose interruption member 7, the dose interruption member 7 is induced to slide in the distal direction a distance corresponding to the adjusted dose due to its engagement to threads 24 on the dose adjustment rotary knob 2.
[023] During injection, due to the fact that the recoil member 9 and the dose adjustment rotary knob 2 are rotatably coupled as previously discussed, the dose interruption member 7 will maintain its position in relation to the threads 24 of the dose adjustment rotary knob 2. The dose interruption member 7 will move in the distal direction during dose adjustment until a distal edge 73 of the dose interruption member 7 is in contiguity with an inward facing key 26 provided in the internal surface of the dose adjustment rotary knob 2, as shown in Figures 14 and 16. In this position, the dose interruption member 7 is prevented from moving in the distal direction which also prevents further rotation of the dose adjustment rotary knob. dose 2 to adjust an additional dose. In this final position, as shown in Figure 16, the dose interruption member 7 is threadably engaged with approximately two or more more distal threads from the threads 24 provided on the dose adjustment rotary knob 2. As shown in relation to Figures 15 and 16, the total distance traveled by the dose interruption member 7 from its initial position to its final position when it is in contiguity with the key 26 provided in the dose adjustment rotary knob 2, is greater than the length of the portions thread 72 and 24 provided on the dose interruption member 7 and the dose adjustment rotary knob 2, respectively.
[024] Figures 20 and 21 illustrate another modality with functionality similar to that described previously, as apparent from the numerical references commonly assigned to the various components in the form of “1xx”. Figures 20 and 21 illustrate an alternative embodiment of the dose interruption member 7 ', as shown. Dose interruption member 107 is still a half-nut type element, but is elongated with a larger number of threads 172. Dose interruption member 107 is now also threadably engaged with only a single thread at% length 129 provided inside the rotary dose adjustment knob 102. The dose interruption member still slides in the distal direction with respect to the recoil member 109 in the same way as previously seen as it is still contiguous with the key 126 inside the button dose adjustment rotary 102. Alternatively, dose interruption members 7 and 107 can be configured to slide similarly in the proximal direction during dose adjustment until dose interruption members 7 and 107 are contiguous with enlarged portions 91 and 191 close to the proximal end of the indentation members 9 and 109, respectively, thus avoiding an additional adjustment of a dose that would exceed the amount of medication remaining in cartridges 15 and 115.
[025] Figures 22 to 28 illustrate a third exemplary embodiment of an injection pen 200 with functionality similar to the previous exemplifying embodiments. Similar numerical references have been included where the components described are substantially in the form of “2xx”. Each of the components of the injection pen 200 shown in Figures 22 to 28 and their respective functionality are substantially the same as the previous exemplary modalities, except where otherwise noted.
[026] The exemplary embodiment described in Figures 22 to 28 includes an additional element referred to as the brake tower core 220. The brake tower core 220 is surrounded by the brake tower 205 and provided axially and rotationally fixed to the brake tower 205. As shown in Figure 24, the brake tower core 220 includes a plurality of teeth 222 provided on an enlarged surface 223 near its proximal end. The plurality of teeth 222 preferably extend axially towards a distal end. The plurality of teeth 222 is configured to engage to engage corresponding teeth 215 provided at a proximal end of the brake tower 205. The engagement of corresponding teeth prevents relative rotation between the brake tower core 220 and the brake tower 205. The brake tower 205 is fixed both axially and rotationally to the upper body of the pen 201 in the same manner as described previously. As shown, the brake tower core 220 is a substantially cylindrical element with an open side 224 extending along the length of the brake tower core 220, as shown in Figure 24. The open side 224 includes approximately one fifth to a quarter of the circumference of a cross section of the brake tower core 220. The open side 224 forms two longitudinally extending edges 225 and 226 at each end of the open side 224.
[027] The brake tower core 220 works to prevent rotation of the plunger rod 206 in relation to the brake tower 205 and, therefore, the upper body of the pen 201. As shown in Figures 25 to 27, the tower core brake rod 220 is surrounded by a hollow piston rod 206. The hollow piston rod 206 includes a plurality of thread segments 262 provided substantially along the entire length of the hollow piston rod 206. Each of the thread segments 262 has a length substantially equal to the portion of the open side circumference 224 of the brake tower core 220. Thread segments 262 extend inwardly into the inner cavity of the hollow piston rod 206. An external surface of the piston rod 206 includes a plurality of window segments 260 which are "drilled through" the surface of the plunger rod 206 to project within it. The window segments 260 are provided to assist in the manufacture of the hollow piston rod 206 to help form the internal thread segments 262. The piston rod 206 is positioned in relation to the brake tower core 220 so that the thread 262 align and protrude into the open surface 224 of the brake tower core, as shown in Figures 25 and 27. In this position, the pair of longitudinally extending edges 225 and 226 are in contiguity with the respective edges of the segments of protruding threads 262, so that the piston rod 106 is prevented from rotating in relation to the brake tower core 220.
[028] Similar to the previous exemplary embodiments, a lead screw 204 is provided inside the hollow piston rod 206. A threaded portion 242 is provided at the distal end of lead screw 204. The threaded portion 242 is configured to engage the thread segments 262 provided inside the piston rod 206. Similar to the previous exemplary embodiments, the lead screw 204 is rotationally fixed to a recoil member 209 so that the rotation of the recoil member 209 during an injection is transferred to the lead screw 204. Axial movement of the lead screw 204 in relation to the brake tower core 220 is prevented in the proximal direction by the lead threads 204 being larger than the opening diameter at a distal end 230 of the brake tower core 220, as shown in Figures 23 and 28. Axial movement of the lead screw 204 in relation to the brake tower core 220 is avoided in the d distal direction by a flange 229 of the lead screw 204 engaging the enlarged portion 223 of the brake tower core 220. As such, due to the threaded engagement between the threaded portion 242 of the lead screw 204 and the thread segments 262 on the stem hollow piston 206, the relative rotation of the lead screw 204 in relation to the piston rod 206 (which is rotationally fixed to the brake tower 205) drives the piston rod 206 axially in the distal direction inside the cartridge 215 to expel the medication contained therein.
[029] Figures 29 to 37 illustrate a fourth exemplary embodiment of an injection pen 300 with functionality similar to the previous exemplifying embodiments. Similar numerical references have been included where the components described are substantially in the form of “3xx”. Each of the components of the injection pen 300 shown in Figures 29 to 37 and their respective functionality are substantially the same as the previous exemplary modalities, except where otherwise noted.
[030] The exemplary embodiment described in Figures 29 to 37 includes a modified brake tower core 320. The brake tower core 320 is surrounded by the brake tower 305 and provided fixed axially and rotationally to the brake tower 305. As shown in Figure 32, the brake tower core 320 has a pair of arms extending opposite 321 and 322 extending from a proximal end 326 thereof. The flaps 324 and 325 extend upwards from the ends of each of the arms 321 and 322. The arms 321 and 322 are received by V-shaped notches 353 at a proximal end 354 of the brake tower 305. The arms 321 and 322 receive the disk-shaped portion 344 (Figure 33) of the lead screw 304 so that the flaps 324 and 325 are in contiguity with the disk-shaped portion 344. Correspondingly, the screw of the advance 304 rotate relative to the brake tower core 320 during an injection. The brake tower 305 is fixed both axially and rotationally to the upper body of the pen 301 in substantially the same manner as described above.
[031] As shown, the brake tower core 320 is a substantially cylindrical element with an open side 327 extending along an axial length of the brake tower core 320, as shown in Figure 32. The open side 327 it includes approximately one-fifth to a quarter of the circumference of a cross section of the brake tower core 320. The open side 327 forms two longitudinally extending edges 328 and 329 at each end of the open side 327.
[032] The brake tower core 320 works to prevent rotation of the plunger rod 306 in relation to the brake tower 305 and, therefore, to the upper body of the pen 301. As shown in Figure 35, the brake tower core 320 is surrounded by a hollow piston rod 306. The hollow piston rod 306 has threads 342 which preferably extend substantially continuously over an entire inner surface 367 of the piston rod 306, as shown in Figures 35 and 37. A flap or key 361 extends radially inward at a proximal end 362 of plunger rod 306, as shown in Figure 34. A flange 366 that serves to engage stop 316 extends outwardly from a distal end of plunger rod 306. Plunger rod 306 is positioned in relation to the brake tower core 320 so that flap 361 is received on the open surface 327 of the brake tower core, as shown in Figure 35. In this position, the pair with longitudinally extending edges 328 and 329 are in contiguity with the respective edges 363 and 364 of the flap 361, so that the piston rod 306 is prevented from rotating in relation to the brake tower core 320, thereby controlling the orientation plunger rod angle 306. The flap or key 361 is located at a proximal end of the plunger rod 306 to which it can remain in the slot type opening 327 of the brake tower core 320 as the plunger rod 306 moves distally.
[033] Similar to the previous exemplary modalities, a lead screw 304 is provided inside the hollow piston rod 306, as shown in Figure 35. A threaded portion 342 is provided at the distal end of the lead screw 304, as shown in Figure 33. The threaded portion 342 is configured to engage the thread segments 362 provided inside the piston rod 306. Similar to the previous exemplary embodiments, the lead screw 304 is rotationally fixed to a recoil member 309 so that rotation of the recoil member 309 during an injection is transferred to the lead screw 304. Axial movement of the lead screw 304 with respect to the brake tower core 320 is prevented in the proximal direction by the threads lead screw 204 being larger than the opening diameter at a distal end 330 of the brake tower core 320, as shown in Figure 35. Axial movement of the screw advance 304 in relation to the brake tower core 320 is avoided in the distal direction by the flaps extending inward 365 of the brake tower 305 which engages a groove 345 of the advance screw 304 disposed between the enlarged portion 323 and the portion with disk shape 344. As such, due to the threaded engagement between the threaded portion 342 of the lead screw 304 and the threads 362 of the hollow piston rod 306, the relative rotation of the lead screw 304 relative to the plunger rod 306 (which is rotationally fixed to the brake tower 305) drives the piston rod 306 axially in the distal direction inside the cartridge 315 to expel the medication contained therein.
[034] Figures 38 to 41 illustrate a fifth exemplary modality of an injection pen 400 with functionality similar to the previous exemplary modalities. Similar numerical references have been included where the components described are substantially in the form of “4xx”. Each of the components of the injection pen 400 shown in Figures 38 to 41 and their respective functionality are substantially the same as the previous exemplary modalities, except where otherwise noted.
[035] The exemplary embodiment described in Figures 38 to 41 includes an additional modified brake tower core 420. The brake tower core 420 is surrounded by the brake tower 405 and provided fixed axially and rotationally to the brake tower 405 The brake tower core 420, as shown in Figures 39 and 40, has a plurality of teeth 422 provided on an enlarged surface 423 close to a proximal end thereof. Preferably, the plurality of teeth 422 extends axially towards a distal end. The brake tower 405 is substantially similar to the brake tower 205 shown in Figure 34 and has a plurality of corresponding teeth 215 provided at a proximal end 216 of the brake tower 205 (Figure 24). The engagement between the teeth of the brake tower 215 (Figure 34) and the teeth of the brake tower core 422 prevents a relative rotation between the brake tower core 420 and the brake tower 405. The brake tower 405 is fixed both axially and rotationally to the upper body of the 401 pen in the same manner as described above.
[036] As shown in Figure 39, the brake tower core 420 has substantially flat opposing walls 491 and 493 extending from the enlarged portion 423. An open side 424 is formed between the opposing walls 491 and 493 extending along an axial length of the brake tower core 420. The open side 424 includes approximately one-fifth to a quarter of the circumference of a cross section of the brake tower core 420. The open side 424 forms two longitudinally extending edges 425 and 426 at each end of the open side 424.
[037] The brake tower core 420 works to prevent rotation of the piston rod 406 in relation to the brake tower 405 and, therefore, to the upper body of the pen 401. As shown in Figures 38 and 40, the tower core brake pad 420 is surrounded by a hollow piston rod 406. The hollow piston rod 406 has threads 462 that extend over the entire internal surface thereof. A hole 381 extends from a proximal end 382 to a distal end 383 of the plunger rod 406. The opposite sides 384 and 385 of an opening 386 that serves to access the hole 381 are substantially flat, as shown in Figure 38.
[038] The piston rod 406 is positioned in relation to the brake tower core 420 so that the flat walls 491 and 493 of the brake tower core 420 are received by the flat portions 484 and 485 of the hole opening 486 of the rod piston 406. Lead screw 404 is inserted through the brake tower core 420 so that lead screw threads 442 engage with piston rod threads 462 in addition to a distal end 494 of the brake tower core 420. The rotation of the lead screw 404 during an injection results in an axial movement of the piston rod 406 due to the threaded engagement between them. The engagement between the flat walls 491 and 493 of the brake tower core 420 and the flat portions 484 and 485 of the piston rod 406 prevents rotation of the piston rod 406 relative to the brake tower core 220 during injections.
[039] Similar to the previous exemplary embodiments, the lead screw 404 is rotationally fixed to a setback member 409 so that the rotation of the setback member 409 during an injection is transferred to the lead screw 404. Axial movement of the lead screw 404 in relation to the brake tower core 420 is prevented in the proximal direction by the lead screw threads 404 being larger than the opening diameter at a distal end 494 of the brake tower core 420, as shown in Figure 41 Axial movement of the lead screw 404 in relation to the brake tower core 420 is prevented in the distal direction by a flange 429 of the lead screw 404 which engages the enlarged portion 423 of the brake tower core 420. As such, due to the threaded engagement between the threaded portion 442 of the lead screw 404 and the threads 462 of the hollow piston rod 406, the relative rotation of the lead screw 404 with respect to the piston rod 406 (which is fixed by hand from the rotational to the brake tower 405) drives the piston rod 406 axially in the distal direction inside the cartridge 415 to expel the medication contained therein.
[040] Figures 42 to 51 illustrate a sixth exemplary modality of an injection pen 500 with functionality similar to the previous exemplary modalities. Similar numerical references have been included where the components described are substantially in the form of “5xx”. Each of the components of the injection pen 500 shown in Figures 42 to 51 and their respective functionality are substantially the same as the previous exemplary embodiments, except where otherwise noted.
[041] As shown in Figure 11, the lead screw 4 presses into an interrupted ring that forms a plurality of protrusions 54 on an internal surface of the brake tower 5. In the sixth example example, a lead screw 504 has a continuous ring 591 to which a brake tower 505 fits by pressure, as shown in Figure 42. The continuous ring 591 is a flexible member that facilitates assembly, as well as withstands disassembly forces due to the continuity of ring 591.
[042] The lead screw 504 has an external thread 542 formed at a distal end 543 to engage the threads of a plunger rod 506, as shown in Figures 43 and 44. The continuous ring 591 is disposed at a proximal end 544 of the lead screw 504. Continuous ring 591 has an inner surface 592 and an outer surface 593. A circumferential ring 594 extends from the inner surface 592 of ring 591. The circumferential ring 594 has an angled surface 595, as shown in Figure 44, to facilitate the insertion of the brake tower 505.
[043] A tower core 520 is arranged on the lead screw 504, as shown in Figure 45. The tower core 520 has an open surface for receiving the lead screw 504. The lead screw 504 and the tower core of brake 520 are then inserted through an opening 581 at a proximal end 583 of the brake tower 505, as shown in Figure 46. Then, the opening 581 at the proximal end 583 of the brake tower 505 flexes outwardly to receive the extended portion 523 of the brake tower core 520, as shown in Figures 47 and 48. The lead screw 504 has not yet been connected to the brake tower 505 to allow opening 581 at the proximal end 583 of the brake tower 505 decompresses, thus reducing tensions on it. The enlarged portion 523 of the brake tower core 520 is received within an internal cavity of the brake tower 505.
[044] As shown in Figure 49, lead screw 504 is pressurely connected to brake tower 505. Pushing lead screw 504 in the distal direction causes the angled surface 595 of ring 594 of ring 591 to flex outward along an angled surface 584 at the proximal end 583 of the brake tower 505. The circumferential rim 594 fits snugly into a recess 585 formed on an outer surface 586 of the brake tower 505 adjacent to the proximal end 583 thereof. The brake tower core 520 has not yet been rotationally locked to the brake tower 505 so that the brake tower core 520 is free to rotate.
[045] As shown in Figure 50, the plunger rod 506 is inserted into the inner cavity of the brake tower 505 from a distal end thereof. The internal threads 562 of the plunger rod 506 are threaded into threads 542 (Figure 45) of the lead screw 504 so that the plunger rod 506 is threaded in the proximal direction on the brake tower 505. The plunger rod 506 is threaded until that a proximal end 563 of the plunger rod 506 is in contiguity with the enlarged portion 523 of the brake tower core 520. The brake tower core 520 is then distally pressed into the brake tower 505, thereby locking the brake tower core 520 to brake tower 505. A pin (not shown) is inserted through a gap 543 in the lead screw threads 542 to facilitate locking the brake tower core 520 to the brake tower 505.
[046] Figures 52 to 75 illustrate a seventh exemplary modality of a 600 injection pen with functionality similar to the previous exemplary modalities. Similar numerical references have been included where the components described are substantially in the form of “6xx”. Each of the components of the injection pen 600 shown in Figures 52 to 75 and their respective functionality are substantially the same as the previous exemplary modalities, except where otherwise noted.
[047] The exemplary embodiment described in Figures 52 to 75 includes an additional element referred to as a click device body 680, as shown in Figures 52 and 67 to 70. The click device body 680 is surrounded by the rotary adjustment knob dose 602, as shown in Figure 53. An upper surface 681 of an upper ring 682 is engaged by a push button 603. A lower surface 689 of the upper ring 682 is engaged by a distal end 690 of an indentation member 609. A pair of flexible arms 683 is connected to the upper ring 682, as shown in Figures 67, 68 and 70. A lower ring 684 is connected to the upper ring 682, as shown in Figure 69. The lower ring 684 has a pair of flexible arms 685 connected to it, as shown in Figures 67 and 68. Hooks 686 are arranged on free ends of the upper ring flexible arms 683, and hooks 687 are arranged on free ends of the flexible arms lower ring levels 687. Preferably, the inclined surfaces of the upper ring hooks 686 and the lower ring hooks 687 form an angle of approximately 15 degrees. An opening 688 is formed in the click device body 680 to receive the push button 603. The upper ring flexible arm hooks 686 engage the teeth 691 of the dose adjustment rotary button 602, as shown in Figure 53. The hooks lower ring flexible arm 687 engage teeth 692 of the recoil member 609.
[048] The brake tower core 620 is surrounded by the brake tower 605 and provided fixed axially and rotationally to the brake tower 605. As shown in Figures 60 and 72 to 74, the brake tower core 620 has a 623 key extending axially at a proximal end. The key 623 is received by a V-shaped notch 653 arranged at a proximal end of the brake tower 605. The key 623 has internally tapered sides, as shown in Figures 72 to 74, to facilitate engagement with the V-shaped notch. 653 of the brake tower 605, thereby rotationally locking the brake tower core 620 to the brake tower 605. The brake tower 605 is fixed both axially and rotationally to the upper body of the pen 601 in the same manner as described above. As shown in Figure 60, the brake tower core 620 is a substantially cylindrical element with an open side 624 extending along an axial length of the brake tower core 620. The open side 624 includes approximately one fifth to one quarter of the circumference of a cross section of the brake tower core 620. The open side 624 forms two longitudinally extending edges 625 and 626 at each open side end 624.
[049] The brake tower core 620 works to prevent rotation of the plunger rod 606 in relation to the brake tower 605 and therefore to the upper body of the pen 601. As shown in Figure 53, the brake tower core 620 is surrounded by a hollow plunger rod 606. The hollow plunger rod 606 includes internal threads 662 extending substantially along the entire length of the hollow plunger rod 606, as shown in Figures 63 and 64. The plunger rod 606 is positioned in relation to the brake tower core 620 so that a key extending internally 661 engages the edges extending longitudinally 625 and 626, so that the piston rod 606 is prevented from rotating in relation to the core of brake tower 620, as shown in Figure 75.
[050] Similar to the previous exemplary modalities, a lead screw 604 (Figure 59) is provided inside the hollow piston rod 606. A threaded portion 642 is provided at the distal end of lead screw 604. The threaded portion 642 is configured to engage the internal threads 662 of the plunger rod 606. Similar to the previous exemplary embodiments, the lead screw 604 is rotationally fixed to the recoil member 609 so that the rotation of the recoil member 609 during an injection is transferred to lead screw 604. Lead screw 604 is press-fit to the brake tower core 620, which is press-fit to brake tower 605, as shown in Figures 53 and 72 to 74. A flange 633 of lead screw 604 is received by a groove 632 (Figure 60) of the brake tower core 620 so that a proximal end of the brake tower core 620 is received by an annular groove 645 of the screw the lead 604 disposed between the proximal flange 646 and the flange 633 spaced internally from the same. A flange 644 of the brake tower core 620 is received by a lip extending inwardly 665 of the brake tower 605. The axial movement of the lead screw 604 relative to the brake tower 605 in the proximal direction is prevented by flange 644 of the brake tower core 620 in contiguity with the lip extending inward 665 of the brake tower 605. Avoiding the proximal axial movement of the brake tower core 620 prevents the proximal axial movement of the lead screw 604, which is connected by a press fit to the brake tower core 620. Axial movement of the lead screw 604 in relation to the brake tower 605 in the distal direction is prevented by a flange 646 of the lead screw 604 in contiguity to a distal end of the brake tower 605. As such, due to the threaded engagement between the threaded portion 642 of the lead screw 604 and the internal threads 662 on the hollow piston rod 606, the relative rotation of the lead screw 604 relative to the piston rod 606 (what is rotationally fixed to the brake tower core 620) drives the piston rod 606 axially in the distal direction inside the cartridge 615 to move the stop 616 to expel the medication contained therein.
[051] To adjust a dose using the injection pen 600 of the seventh example mode, the user rotates the dose adjustment knob portion 602 in relation to the upper body of the pen 601. An external surface 659 of the rotary knob Dose adjustment 602 includes a thread 619, as shown in Figures 54 and 55, which is threaded in engagement with a plurality of threads 617 provided on the inner surface of the upper body of the pen 601, as shown in Figures 65 and 66. Correspondingly , as the dose adjustment rotary knob 602 is rotated in relation to the upper body of the pen 601, the dose adjustment rotary knob 602 screws or advances a distance away from the upper body of the pen 601 (Figure 3). The dose adjustment rotary knob 602 includes an annular shoulder or ring 621 on its inner surface near the proximal end, as shown in Figure 5. Annular shoulder 621 engages an enlarged portion or head 699 (Figures 56 to 58) of the indentation member 609, as shown in Figure 53. The annular shoulder 621 of the rotary dose adjustment knob 602 preferably comprises a series of teeth or grooves 622 which engage with a plurality of similarly shaped teeth or grooves 698 provided in the enlarged head 699 of the recoil member 609. Preferably, the teeth of the dose adjustment rotary knob 622 and the teeth of the recoil member 698 extend in opposite axial directions. During dose adjustment, the dose adjustment rotary knob 602 is free to rotate with respect to the indentation member 609 in either a clockwise or counterclockwise direction. As this occurs, the plurality of teeth or grooves 622 on the rotary dose adjustment knob 602 slides past the teeth 698 provided in the head portion 699 of the setback member 609, thereby providing a tactile signal or click noise to indicate the adjustment of a dosage amount. As further described below, the dose adjustment rotary knob 602 is allowed to rotate in relation to the recoil member 609 during adjustment due to a unidirectional ratchet that prevents the recoil member 609 from rotating next to the dose adjustment rotary knob 602 on adjustment direction.
[052] The click device body 680 facilitates the generation of a tactile signal or click noise during dose adjustment. The upper ring hooks 686 of the click device body 680 are locked to teeth 691 (Figures 54 and 55) of the dose adjustment rotary button 602 so that the click device body rotates next to the dose adjustment rotary button 602 as the dose adjustment rotary knob 602 advances away from the upper body of the pen 601. The lower ring hooks 687 slide over the teeth 692 (Figures 56 and 57) of the recoil member 609. Correspondingly, a tactile signal or clicking noise is generated to indicate to the user that a dose is adjusted.
[053] To correct an adjusted dose that may have been set too high, the user simply rotates the dose adjustment knob 602 back in the opposite direction. The rotation of the dose adjustment rotary knob 602 in this direction is not transferred to the recoil member 609 due to the unidirectional ratchet between the recoil member 609 and the brake tower 605. The recoil member 609 has a pair of 696 ratchet arms. , as shown in Figures 56 to 58. The pair of ratchet arms 696 engages a plurality of splines or teeth 652 provided on the outer surface of the brake tower 605, as shown in Figures 61 and 62. The ratchet arms 696 and splines or teeth 652 are configured to allow relative rotation in only one direction, that is, the direction that allows the injection of an adjusted dose. The friction provided between the ratchet arms 696 and the teeth 652 on the brake tower 605 is greater than the friction between the corresponding teeth 698 and 622 on the recoil member 609 and the dose adjustment knob 602, respectively. Thereafter, the dose adjustment rotary knob 609 can be rotated back to correct an adjusted dose without causing the recoil member 609 to rotate in this direction. Correspondingly, the teeth 692 and 622 provided in the setback member 609 and the rotary dose adjustment knob 602, respectively, slide apart from each other to provide click noise during reverse dose dialing, just as during the adjustment of normal dose, thus indicating a correction of the adjusted dose.
[054] The click device body 680 also facilitates the generation of a tactile signal or click noise during dose correction. The lower ring hooks 687 of the click device body 680 are locked to the teeth 692 (Figures 56 and 57) of the recoil member 609 so that the click device body 680 is rotationally locked to the recoil member 609. The rotation of the dose adjustment knob 602 as the dose adjustment knob 602 is advanced back into the upper body of the pen 601 to correct the dose causes the teeth 691 (Figures 54 and 55) of the rotary knob dose adjustment buttons 602 slide over the lower ring hooks 687 of the click device body 680, thereby generating a tactile signal or click noise to indicate to the user that a dose is being corrected. Correspondingly, the click device body facilitates the generation of a tactile signal or click noise both during dose adjustment and during dose correction.
[055] As the dose adjustment rotary knob 602 screws or advances axially away from the upper body 601 during dose adjustment, the recoil member 609 is also induced to move axially away from the body to a corresponding distance. This axial movement is caused by the engagement between the annular shoulder 621 on the dose adjustment rotary knob 602 pressing against the enlarged head portion 699 of the recoil member 609 during its movement away from the body. Once a desired dose has been adjusted, the user presses the pressure button 603 which is attached to the indentation insert insert 680 which is axially connected to the indentation member 609. Under the force applied by the user pressing the pressure button 603, the recoil member 609 is moved in a locking engagement or coupling to the dose adjustment rotary knob 602 through a coupling of the respective teeth or grooves 698 and 622 provided in the dose adjustment rotary knob 602 and the recoil member 609, respectively. As the user continues to press the pushbutton 603, the dose adjustment rotary knob 602 is induced to rotate and screw back into the upper body of the pen 601 through the threaded engagement between the thread 619 on the rotary adjustment knob. dose 602 and the thread 617 on the upper body of the pen 601. The rotation of the dose adjustment rotary knob 602 is then transferred to the recoil member 609 due to its locking or coupling engagement. The force of the user pressing the button 603 is sufficient to overcome the friction between the ratchet arms 696 on the recoil member 609 and the teeth or splines 652 on the brake tower 605. As a result, the recoil member 609 is allowed to rotate in this direction. As the recoil member 609 rotates with respect to the brake tower 605 during injection, the ratchet arms 696 produce a tactile signal or click noise as the ratchet passes through teeth 652 on the brake tower 605. This indicates to the user that the injection of the adjusted dose is taking place. Due to the fact that the dose adjustment dial 602 and the recoil member 609 rotate together during injection, the click device body does not rotate in relation to the dose adjustment rotary button 602 or the recoil member 609. correspondingly, the click device body 680 rotates both next to the dose adjustment rotary knob 602 and the recoil member 609 so that the click device body 680 does not generate a tactile signal or click noise when injecting a dose adjusted.
[056] The rotation of the recoil member 609, as allowed during the injection, is then transferred to the lead screw 604, which is rotationally fixed to the recoil member 609 through a groove and key connection provided between the lead screw 604 and recoil member 609. As shown in Figures 56 and 57, an internal surface 668 of recoil member 609 includes a groove or slot 697 which is engaged with a key 648 provided at the proximal end of lead screw 604 , as shown in Figure 59. The recoil member 609 preferably includes two opposingly arranged slots 697 for engaging two opposingly arranged keys 648 provided in the lead screw 604. The recoil member 609 moves axially with respect to the screw feed rate 604 during dose adjustment and dose correction, through the interconnection between key 648 and slot 697 (substantially similar to Figure 10). The length of the slot 697 in the setback member 609 can be configured to correspond to a maximum dose to be injected in a single injection. The lead screw 604 is axially fixed in relation to the upper body of the pen 601 by means of a snap fit previously described with the brake tower 605, which is fixed axially and rotationally to the upper body of the pen 601 as described below. As shown in Figures 72 to 74, the lead screw 604 includes the internally disposed flange 633 which is received by the recess 632 in the brake tower core 620. The flange 644 of the brake tower core 620 is received by the lip extending 665 into the brake tower 605, thereby axially locking the lead screw 604 to the brake tower 605 and the upper body of the pen 601.
[057] As previously described, lead screw 604 includes a plurality of threads 642 at its distal end which are threaded to internal threads 662 preferably provided along the entire length of the hollow piston rod 606, as shown in Figures 53 and 64. The plunger rod 606 is kept non-rotating in relation to the upper body of the pen 601 due to the engagement between the plunger rod key 661 and the outer edges 625 and 626 of the brake tower core 620, as shown in Figure 75. The piston rod key 661 is guided in axial motion by the outer edges extending axially 625 and 626 from the brake tower core 620, thus preventing a relative rotation between them while allowing the plunger rod 606 moves axially with respect to them. As the recoil member 609 does not rotate during adjustment and dose correction, the lead screw 604 does not rotate during adjustment and dose correction, which prevents movement of the plunger rod 606 during adjustment and dose correction. Correspondingly, the rotation of the lead screw 604 during injection of a dose causes the threads 642 of the lead screw 604 to engage with threads 662 of the piston rod 606, thereby moving the piston rod 606 axially.
[058] During assembly, the brake tower 605 is inserted into the upper body of the pen 601 from the distal end. As shown in Figures 53 and 66, the upper body of the pen 601 includes a cross wall 660 that limits the movement of the brake tower 605 in the body 601 by blocking an enlarged distal portion 666 of the brake tower 605. In addition, a key projecting inwardly 663 is also provided distally from the transverse wall 660 on an internal surface 664 of the upper body of the pen 601, as shown in Figure 66. The key 653 engages a slot 655 provided in the extended distal portion 666 of the tower lock 605, as shown in Figures 61 and 62, to rotationally secure the brake tower 605 in relation to the upper body of the pen 601. Preferably, a plurality of axially extending keys 663 is arranged on the inner surface of the upper body of the pen 601 to engage a plurality of slots 655 in the extended distal portion 666 of the brake tower 605.
[059] Due to the fact that the plunger rod 606 is not rotatable in relation to the body 601, as the lead screw 604 is induced to rotate during the injection, as previously described due to its rotational coupling to the indentation 609, the plunger rod 606 through its threaded engagement with the lead screw 604 is induced to move in the distal direction to press against the stop 616 provided in the medicine cartridge 615, thus expelling a liquid medication from the same . The piston rod 606 is prevented from moving in the proximal direction because the lead screw 604 is rotatable only in a single direction (which results in a distal movement of the piston rod 606) due to the unidirectional ratchet between the recoil member 609 and the brake tower 605. A mechanical advantage is preferably provided so that the dose adjustment rotary knob 602 moves more in the axial direction than the plunger rod 606 during injection, reducing the injection force that must be applied by the user. This is preferably accomplished by providing different pitches to the threaded connection between the dose adjustment rotary knob 602 and the upper body of the pen 601 and the threaded connection between the lead screw 604 and the plunger rod 606. The ratio between the pitches threads may vary depending on the liquid medication and the expected dose volumes. For example, the slope ratio can be 4.35: 1 or 3.25: 1, but not limited to these. Therefore, an accurate dosage can be guaranteed because the plunger rod 606 keeps its engagement with the stop 616 between injections.
[060] A dose interruption member 607, as shown in Figure 53, is provided for last dose management, to avoid adjusting a dose that is greater than the remaining amount of medication in the 615 cartridge. The interruption member dose 607 is axially slidable, but rotationally fixed in relation to the recoil member 609 being positioned between a pair of grooves 694 provided on the outer surface of the recoil member 609. The dose interrupt member 607 is a half-nut type element ( Figure 2b) which is threaded on its outer surface with a plurality of threads 672. These threads 672 are configured to engage the corresponding threads 674 provided inside the dose adjustment rotary knob 602, as shown in Figure 55. During adjustment dose, as the dose adjustment rotary knob 602 rotates with respect to the setback member 609, and therefore also with respect to the dose interrupt member 607, the mem dose interruption bracket 607 is induced to slide in the distal direction a distance corresponding to the adjusted dose due to its engagement with threads 674 on the dose adjustment rotary knob 602.
[061] During injection, due to the fact that the recoil member 609 and the rotary dose adjustment knob 602 are rotatably coupled as previously discussed, the dose interrupt member 607 will maintain its position in relation to the threads 674 of the dose adjustment rotary knob 602. Dose interruption member 607 will move in the distal direction during dose adjustment until a distal edge 673 of dose interruption member 607 is contiguous with an inward facing key 675 provided in the inner surface of the dose adjustment rotary knob 602, as shown in Figure 55. In this position, the dose interruption member 607 is prevented from moving further in the distal direction, which also prevents further rotation of the dose adjustment knob dose 602 to adjust an additional dose.
[062] Figures 76 to 80 illustrate an eighth exemplifying modality of an injection pen with functionality similar to the injection pen of the seventh exemplifying modality shown in Figures 52 to 66 and 71 to 75. The exemplary modality described in Figures 76 a 80 includes a modified click device body 751 that replaces the click device body 780 of Figures 52 to 66 and 71 to 75. The remaining components and functions of the injection pen are substantially similar to the injection pen 600.
[063] The click device body 751 is substantially ring-shaped having an upper set of teeth 752 and a lower set of teeth 753, as shown in Figures 76 and 77. Preferably, the upper teeth 752 have an inclination that it is opposite to that of the lower teeth 753. Preferably, the inclined surfaces of the upper teeth 752 and the lower teeth 753 form an angle of approximately 15 degrees. As shown in Figures 76 and 80, the click device body 751 is disposed between an annular shoulder 725 of the rotary dose adjustment knob 702 and an enlarged portion 731 of the recoil member 709. A plurality of teeth 721 extend axially in the proximal direction from the shoulder 725 of the rotary dose adjustment knob 702. A plurality of teeth 723 extend axially in the distal direction from the enlarged portion 731 of the recoil member 709. A pad insert 708 is received in one annular groove 726 of the recoil member 709, as shown in Figure 80. A pushbutton 703 has a projection 733 received by an opening 734 in the cushion insert 708. A distal skirt 735 of the pushbutton 703 is received so sliding through a recess 736 adjacent to a proximal end 737 of the dose adjustment rotary knob 702.
[064] The click device body 751 facilitates the generation of a tactile signal or click noise during dose adjustment. The upper teeth 752 of the click device body 751 are locked to the teeth 721 (Figure 79) of the dose adjustment rotary knob 702 so that the click device body 751 rotates next to the dose adjust rotary knob 702 to measure that the dose adjustment rotary knob 702 advances away from the upper body of the pen. The lower teeth 753 slide over the teeth 723 (Figure 78) of the recoil member 709. Correspondingly, a tactile signal or click noise is generated to indicate to the user that a dose is being adjusted.
[065] The click device body 751 also facilitates the generation of a tactile signal or click noise during dose correction. The lower teeth 753 of the click device body 751 are locked to the teeth 723 (Figure 78) of the recoil member 709 so that the click device body 751 is rotatably locked to the recoil member 709. Rotation of the knob dose adjustment dial 702 as the dose adjustment dial 702 is advanced back into the upper body of the pen to correct the dose causes teeth 721 (Figure 79) of the dose adjustment dial 702 to slide over the lower teeth 753 of the click device body 751, thereby generating a tactile signal or clicking noise to indicate to the user that a dose is being corrected. Correspondingly, the click device body 751 facilitates the generation of a tactile signal or click noise both during dose adjustment and during dose correction.
[066] Due to the fact that the dose adjustment rotary knob 702 and the recoil member 709 rotate together during an injection, the click device body 751 does not rotate in relation to the dose adjustment rotary knob 702 or the limb. indentation 709. Correspondingly, the click device body 751 rotates both next to the dose adjustment rotary knob 702 and the indentation member 709 so that the click device body 751 does not generate a tactile signal or click noise. when injecting an adjusted dose.
[067] Although the present invention has been shown and described with reference to particular illustrative modalities, it is not restricted to these exemplary modalities, but only to the appended claims and their equivalents. It should be assessed that individuals skilled in the art can change or modify the exemplary modalities without departing from the scope and spirit of the present invention, as defined in the attached claims and their equivalents.

权利要求:
Claims (39)
[0001]
1. Medication injection pen (51, 200, 300, 400, 500, 600), CHARACTERIZED by the fact that it comprises: a housing (1); a rotary dose adjustment knob (2) comprising at least one internal tooth (22); a brake member (5) having a plurality of axially extending splines (52); and a driver (9) including at least one external tooth (92) engaging said at least one internal tooth (22) of said dose adjustment rotary knob (2) and at least one ratchet arm (96) engaging said plurality of splines extending axially (52), wherein said actuator (9) is unable to rotate with said dose adjustment rotary knob (2) while moving axially with said dose adjustment rotary knob (2) during dose adjustment and dose correction, and said actuator (9) rotates with said dose adjustment rotary knob (2) during an injection.
[0002]
2. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 1, CHARACTERIZED by the fact that said at least one ratchet arm (96) engages said plurality of grooves extending axially (52) to prevent rotation of said actuator (9) with said dose adjustment rotary knob (2) during dose adjustment and dose correction, and said at least one ratchet arm (96) passes through the said grooves extending axially (52) to allow rotation of said actuator (9) with said dose adjustment rotary knob (2) during dose injection.
[0003]
3. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 2, CHARACTERIZED by the fact that said dose adjustment rotary knob (2) rotating in relation to said trigger (9) during dose adjustment and dose correction generates a first audible indication, and said actuator (9) rotating in relation to said brake member (5) during injection generates a second audible indication.
[0004]
4. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 1, CHARACTERIZED by the fact that a lead screw (4) is fixed axially and rotationally during dose adjustment and dose correction, and said lead screw (4) rotates with said driver (9) during dose injection.
[0005]
5. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 4, CHARACTERIZED by the fact that a hollow piston rod (6) is moved axially during rotation injection of the said lead screw (4).
[0006]
6. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 5, CHARACTERIZED by the fact that said driver (9) is moved axially in relation to the lead screw (4) during said dose adjustment and said dose correction.
[0007]
7. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 6, CHARACTERIZED by the fact that said lead screw (4) has a key (48) and said the driver (9) has a slot (98) to receive said key (48) so that said driver (9) moves axially with respect to said lead screw (4) during dose adjustment.
[0008]
8. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 7, CHARACTERIZED by the fact that a length of said groove (98) corresponds to a maximum dose adjustment.
[0009]
9. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 1, CHARACTERIZED by the fact that a dose interruption member (7) is disposed in said trigger (9) , said dose interruption member (7) moving axially in said trigger (9) during dose adjustment and dose correction and said dose interruption member (7) rotating with said trigger (9) during dose injection.
[0010]
10. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 9, CHARACTERIZED by the fact that said dose interruption member (7) engages a protuberance arranged on a surface internal of said dose adjustment rotary knob (2) to avoid adjusting an excess dose of medicine remaining in said injection pen (51, 200, 300, 400, 500, 600).
[0011]
11. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 4, CHARACTERIZED by the fact that said brake member (5) fits by pressure to an external surface of the said lead screw (4).
[0012]
12. Medication injection pen (51, 200, 300, 400, 500, 600), CHARACTERIZED by the fact that it comprises: a housing (1); a rotary dose adjustment button (2) to adjust and correct a dose; a brake member (5) fixed axially and rotationally to said housing (1); a driver (9) moving axially with said dose adjustment knob (2) when adjusting and correcting the dose with said dose adjustment knob (2) and moving rotationally with said dose adjustment knob dose (2) when injecting an adjusted dose; a hollow plunger rod (6) moving axially when injecting the adjusted dose; and a brake core member (220) disposed within said hollow piston rod (6) to substantially prevent rotational movement of said hollow piston rod (6).
[0013]
13. Medication injection pen (51, 200, 300, 400, 500, 600) according to claim 12, CHARACTERIZED by the fact that said brake core member (220) is substantially cylindrical and has a portion open to receive a lead screw (4).
[0014]
14. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 13, CHARACTERIZED by the fact that: said hollow piston rod (6) has a plurality of thread segments (262) on an internal surface of it; and said open portion of said brake core member (220) engages said plurality of thread segments (262) to prevent rotation of said hollow piston rod (6).
[0015]
15. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 13, CHARACTERIZED by the fact that: said hollow plunger rod (6) is continuously screwed into a socket internal surface of it.
[0016]
16. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 15, CHARACTERIZED by the fact that: a flap (324, 325) extends inwards from a surface internal of said hollow piston rod (6); and said open portion of said brake core member (220) engages said flap (324, 325) to prevent rotation of said hollow piston rod (6).
[0017]
17. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 13, CHARACTERIZED by the fact that said brake core member (220) has substantially flat external surfaces oppositely disposed; and said hollow plunger rod (6) has an opening with substantially flat opposing sides, said substantially flat outer surfaces of said brake core member (220) engaging said substantially flat opposing sides of said hollow plunger rod (6) to substantially prevent it from rotating.
[0018]
18. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 12, CHARACTERIZED by the fact that: said brake core member (220) has a pair of arms extending outward (321, 322); and said brake member (5) has a pair of recesses (353) for receiving said arms (321, 322) extending outwardly, thus preventing rotation of said brake core member (220).
[0019]
19. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 13, CHARACTERIZED by the fact that said lead screw (4) fits by pressure on an external surface of the said brake member (5).
[0020]
20. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 12, CHARACTERIZED by the fact that said dose adjustment rotary knob (2) rotating in relation to said trigger (9) during dose adjustment and dose correction generates a first audible indication, and said actuator (9) rotating in relation to said brake member (5) during dose injection generates a second audible indication.
[0021]
21. Medication injection pen (51, 200, 300, 400, 500, 600), CHARACTERIZED by the fact that it comprises: a housing (1); a push button (3) at a proximal end of said housing (1); a rotary dose adjustment knob (BRAD) (2) comprising at least one internal tooth (22) and a ring of BRAD ratchet teeth on said dose adjustment rotary knob (2); a brake member (5) having a plurality of axially extending splines (52); a driver (9) including at least one external tooth (92) engaging said at least one internal tooth (22) of said rotary dose adjustment knob (2), at least one ratchet arm engaging said plurality of splines if extending axially (52) and a ring of driver ratchet teeth in said driver (9); a click device (680) operatively engaged between said dose adjustment rotary knob (2) and said actuator (9) having at least one BRAD ratchet arm for engaging said BRAD ratchet teeth and at least one driver ratchet arm for engaging said driver ratchet teeth; wherein said actuator (9) is unable to rotate with said dose adjustment rotary knob (2) while moving axially with said dose adjustment rotary knob (2) during dose adjustment and dose correction, and when said push button (3) is pressed, said click device (680) is moved distally and presses said actuator (9) distally so that said at least one external tooth (92) of said actuator (9 ) engages said at least one internal tooth (22) of said dose adjustment rotary knob (2) thereby forcing said driver (9) to rotate with said dose adjustment rotary knob (2) during an injection.
[0022]
22. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said dose adjustment rotary knob (2) rotating in relation to said device of click (680) during dose adjustment generates a first audible indication, and said trigger (9) rotating in relation to said click device (680) during dose correction generates a second audible indication.
[0023]
23. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that a lead screw (4) is fixed axially and rotationally during dose adjustment and dose correction, and said lead screw (4) rotates with said driver (9) during dose injection.
[0024]
24. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 23, CHARACTERIZED by the fact that a hollow piston rod (6) is moved axially during the injection by rotation of the said lead screw (4).
[0025]
25. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 24, CHARACTERIZED by the fact that said actuator (9) is moved axially in relation to a screw advance (4) during said dose adjustment and said dose correction.
[0026]
26. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 25, CHARACTERIZED by the fact that said lead screw (4) has a key (48) and said the driver (9) has a slot (98) to receive said key (48) so that said driver (9) moves axially with respect to said lead screw (4) during dose adjustment.
[0027]
27. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 26, CHARACTERIZED by the fact that a length of said groove (98) corresponds to a maximum dose adjustment.
[0028]
28. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that a dose interruption member (7) is disposed in said trigger (9) , said dose interruption member (7) moving axially in said trigger (9) during dose adjustment and dose correction and said dose interruption member (7) rotating with said trigger (9) during dose injection.
[0029]
29. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 28, CHARACTERIZED by the fact that said dose interruption member (7) engages a protuberance arranged on a surface internal of said dose adjustment rotary knob (2) to avoid adjusting an excess dose of medicine remaining in said injection pen (51, 200, 300, 400, 500, 600).
[0030]
30. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that it further comprises a brake member (5) having a plurality of axially extending grooves (52) and said driver (9) has at least one spline ratchet arm engaging said plurality of splines extending axially (52).
[0031]
31. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 30, CHARACTERIZED by the fact that said at least one streak ratchet arm engages said plurality of striations if extending axially (52) to prevent rotation of said actuator (9) with said dose adjustment rotary knob (2) during dose adjustment and dose correction, and said at least one spline ratchet arm passes over said splines extending axially (52) to allow rotation of said actuator (9) with said dose adjustment rotary knob (2) during dose injection.
[0032]
32. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 31, CHARACTERIZED by the fact that said dose adjustment rotary knob (2) rotating in relation to said trigger (9) during dose adjustment and dose correction generates a first audible indication, and said actuator (9) rotating in relation to said brake member (5) during injection generates a second audible indication.
[0033]
33. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said BRAD ratchet teeth are located at a proximal end of said rotary knob dose adjustment (2).
[0034]
34. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said trigger ratchet teeth are located at a proximal end of said trigger ( 9).
[0035]
35. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said click device BRAD ratchet arm (680) is a cantilever arched.
[0036]
36. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said click device driver ratchet arm (680) is a cantilever arched.
[0037]
37. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said click device BRAD ratchet arm is an arched cantilever having a first radius and said click device driver ratchet arm is an arched cantilever having a second radius, smaller than said first radius.
[0038]
38. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 21, CHARACTERIZED by the fact that said pressure button (3) has a distal protuberance that engages a central opening on said click device (680).
[0039]
39. Medication injection pen (51, 200, 300, 400, 500, 600), according to claim 31, CHARACTERIZED by the fact that a first rotational friction to rotate said actuator (9), thus screwing the said at least one spline ratchet arm, is greater than a second rotational friction to rotate said actuator (9) in relation to said click device (680), thereby ratcheting said at least one actuator ratchet arm .

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CN105944186B|2016-05-18|2019-08-02|苏州鹏烨医疗科技有限公司|A kind of injection pen|

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CN106983931A|2017-05-08|2017-07-28|甘肃成纪生物药业有限公司|A kind of injection pen|

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RU2695625C1|2019-02-18|2019-07-24|Общество с ограниченной ответственностью «НЭКСТ БИО»|Injection device|

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RU2696451C1|2019-03-27|2019-08-01|Общество с ограниченной ответственностью «НЭКСТ БИО»|Injection syringe|

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RU2700459C1|2019-04-03|2019-09-17|Общество с ограниченной ответственностью «НЭКСТ БИО»|Device for drug delivery|

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US20210008282A1|2019-07-09|2021-01-14|Becton, Dickinson And Company|Self-Controllable Load Spring Washer|

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RU2729442C1|2019-10-23|2020-08-06|Общество с ограниченной ответственностью "НЭКСТ БИО"|Device for drug delivery|

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RU2733692C1|2020-01-24|2020-10-06|Александр Александрович Петров|Syringe pen|

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EP3884974A1|2020-03-27|2021-09-29|Becton, Dickinson and Company|Improved systems, components, and combinations thereof for pen-type injection devices|

法律状态:
2018-12-18| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-10-08| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2020-10-06| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

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2021-02-02| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2021-03-16| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2012, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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US201161457391P| true| 2011-03-16|2011-03-16|

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US61/457,391|2011-03-16|

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PCT/US2012/029308|WO2012125876A1|2011-03-16|2012-03-15|Multiple use disposable injection pen|

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