• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    implant, especially for occlusion of bifurcal aneurysms. the invention relates to an implant (1) to be used in the occlusion of aneurysms in the area of branching vessels, especially bifurcated aneurysms (a), with a mesh structure (3, 4), which is close to distant. - presents the segments (a) to (d): (a) a close segment that narrows and in which the mesh structure is assembled into one or more coupling elements (10); (b) a fixation segment with which the implant can be supported on a container wall; (c) a permeable segment to the vessel bifurcation region and; (d) a distant segment in which the implant, in relation to segment (b), is enlarged and which is intended for positioning in the aneurysm (a), and in the region of segments (c) or (d), a separation zone (t1, t2).
    公开号:BR112013021368B1
    申请号:R112013021368-0
    申请日:2012-02-22
    公开日:2021-08-24
    发明作者:Ralf Hannes；Hermann Monstadt
    申请人:Phenox Gmbh；
    IPC主号:
    专利说明:

    [0001] The present invention relates to an implant to be nailed for occlusion of aneurysms and vessel branches, especially bifurcal aneurysms. An implant of this type will be positioned at the implant site with the aid of a catheter and guide wire, where it will be permanently implanted. Correspondingly, the invention also refers to an implant of this kind, coupled, in ready state, to a conductor wire.
    [0002] Arteriovenous deformations can result in a patient considerable damage and danger until death. This is especially explained for aneurysms, especially when they present in the brain area. Usually, one tries to close such deformations through implants. These implants will normally be applied endovascularly with the aid of catheters.
    [0003] Especially in cerebral aneurysms, the implantation of platinum spirals has been approved that fill the aneurysm more or less completely, largely blocking the blood flow and causing a local thrombus to form that fills the aneurysm and finally closes it. This method of treatment, however, is only suitable for aneurysms that have a relatively narrow access to the vascular system, the so-called aciniform aneurysms. In the case of emptying of blood vessels that have wide access to the vessel, the implanted spirals threaten to be removed by the flow. These are then deposited in another region of the vascular system and can cause further damage there.
    [0004] In these cases, it has already been proposed to introduce a destent species that, so to speak, applies a "grid" in the opening of the aneurysm and in this way avoids the removal by the flow of the occlusion spirals. These stents, which have a relatively wide mesh wall, are already used in some forms of aneurysms.
    [0005] Vessel branching especially vessel bifurcations is a relatively frequent phenomenon. Blood that through an artery in the region of a bifurcation collides with the frontal wall results - in the case of a weakening of the vessel wall - quickly in an emptying which then expands very quickly. These bifurcated aneurysms often have a wide neck that makes the introduction of occluding spirals impracticable.
    [0006] At the same time, there is a lack of stent structures that are suitable to produce in the region of a branch of the vessel a kind of "grid" of the aneurysm entrance. These stents can only be produced with difficulty and with high costs and, in addition, they are extremely difficult to position. From this point of view, it is the object of the invention to provide an implant that is suitable for use especially in the area of bifurcated aneurysms, where they produce the so-called "grid" of the entrance of an aneurysm. With the occlusion spirals then introduced, the aneurysm can then be paralyzed.
    [0007] A "grid" can also be imagined in the sense of an influence of the bloodstream to reduce the number of stop spirals or to reach the zero level.
    [0008] This task will be solved with an implant with a mesh structure that - from proximal to distal - presents segments a to d: (a) a proximal segment that narrows and in which the mesh structure is joined in one or more coupling elements; (b) a fixation segment with which the implant can be supported on a vessel wall; (c) a permeable segment for the region of the vessel bifurcation and; (d) a distal segment in which the implant, in relation to segment (d), is enlarged and which is intended for placement in the aneurysm, in the region of segments (c) or (d), especially between segments c and d, a separation zone is provided.
    [0009] The notions "proximal" and "distal" must be understood in such a way that they designate parts of the implant that point in the direction of the conducting wire and, therefore, to the catheter and the physician performing the treatment (proximal), that is, sections that point towards the distance from the conducting wire or from the physician who performed the treatment (distal). Then, "proximal" comprises the side of the lead wire and "distal" is offset from the lead wire.
    [00010] In the implant according to the invention, it is an implant with a mesh structure that can consist of a weaving of different threads, it can have a mesh structure sectioned from a tube or a combination of both. In this sense, it is the implantation of a stent or a structure similar to a stent that stands out due to the special form of its use and constitution.
    [00011] The implant according to the invention, in total, is subdivided into four segments, segments (a) to (d) seen from proximal to distal.
    [00012] Segment (a) is a narrowing proximal segment in which the mesh structure is joined to one or more coupler elements. The coupling elements are preferably located on the periphery, i.e. in an implanted state they are positioned on the vessel wall. A centered layout is also not useful for technical application reasons; the peripheral arrangement of one or more coupler elements facilitates, in case of wrong placements, the retraction of the implant towards the positioning catheter. Embodiments with one or two coupling elements are preferred.
    [00013] The segment (b) is a segment (d) and fixation with which the implant rests on the wall of the vessel that supplies the blood. In this region, the vessel is undamaged and adapts to be subjected to a stent wall. In the case of high-expansion implants, segment (b) after the release of the catheter, is automatically applied to the vessel wall, in the case of an implant positioned with a balloon, the implant will be enlarged in this area by means of a positioning balloon and pressed against the wall of the vessel.
    [00014] The permeable segment (c) which can especially present a mesh width greater than the segment (b) and which is placed in the region of the specific bifurcation of the vessel. A larger mesh bifurcation allows for more or less uninhibited blood flow through the meshes to the removal vessel branches.
    [00015] The distal segment (d), in relation to the segment (b), and generally also in relation to the segment (c), is enlarged outwards. It serves for positioning in the aneurysm itself, against whose expanding wall it must fit.
    [00016] In the region of the segment (c) and (d), especially between the segments (c) and (d), there is a separation zone that should serve especially for tension of the occlusion means applied to the bifurcated aneurysm.
    [00017] The enlargement of the segment (d) of the implant according to the invention is preferably in the form of a trumpet or a basket. A widening of this type can also be produced by braiding or forming loops. Such a loop-shaped flare usually has at least two loops, especially three loops or more. The loops can be correspondingly shaped wire elements, but they can also - as long as the implant is carried in a tube - if produced correspondingly by laser cutting the same tube.
    [00018] The implants according to the invention can be produced from conventional stent materials, for example, medical steel or cobalt-chromium alloys, however, especially they can consist of material with shape memory effect, possibly nitinol or ternary nickel-titanium alloys.
    [00019] As already indicated, an implant according to the invention is, at least in part, cut from a tube, especially from a tube of an alloy with shape memory effect.
    [00020] The separation zone provided for in the implant according to the invention extends, in this case, in particular, between the segments (c) and (d). In this context, it should be noted that segment (c), at least at one distal end, may already be widened in front of segment (b), which will be useful when the bifurcated aneurysm has already occupied parts of the "rebound wall" of the branches of the vessels. In this hypothesis, the incipient section of the aneurysm must be kept free for the blood stream to be branched, so that the separation zone takes place inside the aneurysm itself. The already widened area in segment (c) will then eventually converge with another widening in segment (d). Here, too, the separation zone is situated between segments c and d. In case of a very flat conformation of the segment (d), the separation zone may also coincide with the segment (d).
    [00021] The separation zone can be formed on the one hand by the introduction of fibers, wires, thin wires, a diaphragm or similar separating elements, but it can also be an integral part of the implant in the sense that they are cut separating elements of the starting tube and correspondingly deformed, if necessary, loops or threads. What is essential is that this separation zone fulfill its function, that is, to securely retain in the distal area (d) of the implant, introduced occlusion means, such as occlusive spirals or to divert the blood stream in such a way that others are unnecessary means of occlusion.
    [00022] If the separation zone is formed by the introduction of fibers, threads or thin wires, it will be convenient to arrange eyelets in the area of the separation zone. For example, the stitches of segment (d) can be provided with corresponding eyelets to be interlocked in a cross or star shape on the nylon threads.
    [00023] However, the separation zone can also be formed by arcs cut from the raw material, with the meshes of the segment (d) being deformed towards the outside and the arcs of the separation zones are bent inside the implant body. At least one bow is needed. In the case of two to four arches, these form a stable separating element that securely retains an occlusion medium introduced into an aneurysm.
    [00024] The distal segment (d) of the implant according to the invention is especially atraumatic, being shaped in a soft and elastic way. The walls of aneurysms are sensitive and can break in case of load, which will have to be avoided anyway. Correspondingly, especially the distal segment (d) of the implant according to the invention must be shaped in an atraumatic sense. This will be achieved, for example, with the arrangement of loops that at the point where they come into contact with the wall of the aneurysm, smoothly adjust to that wall. These ties, as well as the other regions of the implant, will be generated by laser cutting a tube, but they can also be produced through fixed wires that, for example, are laser welded with the segment (c). This convergence zone is covered especially with the separation zone, but it can also represent another extended area of the segment (c) with a spaced separation zone disposed therein.
    [00025] In any case, it is important to atraumatically gather all the wire ends in the distal segment (d) in order to avoid a perforation of the aneurysm wall.
    [00026] The stitches in the distal segment (d) can end up as rounded arcs, especially also in the distal end can have bumps, which in a natural way are also rounded and atraumatic. These protrusions have the effect that the implant in stretched form allows the catheter to be displaced in stretched form in a simpler way, that is, with less use of force.
    [00027] The implants according to the invention may have the form of a laterally closed tube over their entire length, formed of a mesh structure, however, they may also be partially or continuously split. This slit can extend axially parallel or obliquely in the form of a helix. In such a case, in the slit areas, the mesh structure is rolled up correspondingly to the shape of the vessel, possibly in the form of a thread wrapped around the mesh wire fence.
    [00028] In the insertion of an implant thus split, this procedure allows a good fit to the vessel lumen, especially the adductor vessel, and a reduced under or over covering of the lateral edges of the mesh structure is usually not problematic.
    [00029] A partial cleft formation ending in the distal segment (d) is preferred. A slit formation of this nature allows for better adaptation to the layout of the vessel, especially in the area of segment (a) to (e), and, therefore, for a better fixation of the implant in the vessel. Surprisingly it was revealed that crack formation does not need to have a negative influence on the radial force.
    [00030] The implants according to the invention usually have marking elements and facilitate placement at the implant site. These marking elements are arranged, for example, in the area of the distal ends of the segment (d), and in the case of joined wires they can atraumatically deform the joining points. These marking elements can, however, also be present in the form of windings in wire loops or as clamps in the area of transition of segments (c) and (d). For the marking elements, especially platinum and platinum alloys are considered as materials, for example an alloy of platinum and iridium, as is widely used in the prior art for marking purposes and as a material for occlusion coils.
    [00031] Finally, the invention relates to an implant according to the description made above, which is coupled to a wire, that is, conventional conductor wire. This coupling can be done, for example, by means of joining elements that dissolve electrolytically under the influence of an electric current. These connecting elements in materials are widely described, especially for the separation of occlusive and distal spirals. A mechanical separation by coupling elements is also perfectly possible, these coupling elements cooperating with correspondingly suitable coupling components of the conductor wire. Under external coercion of a catheter or sheath, this connection remains intact; after expulsion of the implant and the coupling point of the catheter or casing, however, the connection is canceled and the implant is released with the coupling elements belonging to the implant.
    [00032] The implants according to the invention will be placed with the aid of a conventional catheter or microcatheter; this technique is generally tried and is being used widely.
    [00033] The invention will be explained in more detail by the attached illustrations. The figures show: Figure 1 - as a main sketch a bifurcated aneurysm; Figure 2 - schematically, an implant according to the invention, inserted in the area of a vessel bifurcation with a bifurcated aneurysm; Figure 3 - the implant of the invention with its sections in principle; Figure 4 - an implant according to the invention, as can be used according to figure 2; Figure 5 - variant for segment (d) of an implant according to the invention; Figure 6 - preferred modality of an implant according to the invention spatially expanded; Figure 7 - another modality of an implant according to the invention according to figure 6; Figure 8 - variant of an implant according to the invention with loop-shaped distal segments (d); Figure 9 - bifurcated aneurysm with lateral vessels branching from the aneurysm area and an inserted implant according to the invention; Figure 10 - in enlarged spatial form, variants of implants according to the invention; Figure 11 - another variant with curved arches those in and out in segment (d); Figure 12 - another variant with joint joint devices in segment (c); and Figure 13 - another variant of an implant according to the invention with increased flexibility.
    [00034] Figure 1 shows a bifurcated aneurysm with an adductor z vessel, two outflow vessels x and y, as well as aneurysm A integrated into the bifurcation. The long arrows represent the bloodstream that enters the shock side of aneurysm A and from there exerts outward pressure, under which the aneurysm widens (small arrows).
    [00035] Figure 2 shows a constellation of vessels with an aneurysm A as described in figure 1, with implant 1 integrated therein according to the invention, the implant has a proximal end 2 that presents the coupler element and upon separation converges in the lead wire (not shown). The implant 1, through its meshes 3, is anchored in the wall of the adductor vessel z, which presents meshes 4 with a larger mesh size in the bifurcation region. In the neck of the aneurysm a distal region 5 is shown. Between the distal area 5 and the area with the meshes 4 enlarged, there is a separation zone for retaining the occlusion means introduced into the aneurysm A after positioning the implant.
    [00036] The enlarged meshes 4 in the bifurcation region allow the blood stream that enters the adductor Z vessel to flow to the X and Y branches without encountering major obstacles. After positioning occlusion means not shown here in aneurysm A, the blood flow to aneurysm A is so impaired that a plug is formed there and therefore aneurysm is paralyzed. Alternatively, occlusion occurs without occluding means as long as the separation zone is sufficiently dense.
    [00037] Figure 3 schematically shows an implant according to the invention and its subdivision into different segments.
    [00038] Implant 1 has a proximal segment (a) in which the implant narrows and ends in a coupler element, shown here as wire. This segment corresponds to region 2 in figure 2.
    [00039] Here, segment (b) follows distally and serves to fix the implant on the wall of the adductor container Z. This region has meshes 3 with a relatively narrow mesh width that produces a good contact with the container wall.
    [00040] In distal position, follows the segment (c) which presents meshes 4 with a relatively large width. This region is intended to release penetrating blood to the X and Y branch, see figure 1 and 2.
    [00041] The distal end of the implant 1 is the segment (d), in which the structure 5, in the case shown, is enlarged in the form of a trumpet. This region is then positioned in aneurysm A. Segment (d) can be an integral part of the implant, that is, together with segment (a) to (c) it can be cut from a tube (nitinol) or it can be braided from wires of this kind. But it is also possible to cut segments a through c of a tube and braid segment (d) and weld with segment (c).
    [00042] Between segments (c) and (d) the separation zone T1 is shown, which has one or several separating elements 6. These separating elements can be yarns, yarns, wires or fibers, possibly polyamide, but also of parts of a cut structure that has been deformed inwards. This separation zone T1 with the separation elements 6 serves to retain occlusion means applied inside the aneurysm.
    [00043] According to the type of aneurysm, the separation zone can also be displaced in the segment (d) or can even be found at the distal end of the segment (d). A separation zone of this type T2 is especially useful when the bifurcation is so transformed that the branched X and Y vessels do not branch directly from the adductor Z vessel, but branch from the aneurysm itself. In this case, the separation zone should be placed immediately above the branches in the area of the implant that is widening. Segment (d) is restricted to the distal end of implant 1 and converges in the separation zone T2.
    [00044] Figure 4 shows an implant 1 according to the invention, as it can be used according to figure 2. The implant 1 is shown with a conducting wire 9 and at its near end 2 presents a marking spiral 7 sealed to X-rays. One or more coupling elements, through which the guide wire 9 is joined with an implant 1, are not shown, but are located in the region of the marking spiral 7.
    [00045] The implant presented is a braid of several wires that preferably consist of nitinol and on which the final implant shape is stamped. Nitinol as a material with shape memory effect allows the implant to be guided in compressed form in a catheter without losing profiling. After releasing the catheter, the implant acquires the shape it was impregnated with so that it can fulfill its purpose of use.
    [00046] The implant 1 is subdivided into four segments (a) to (d), and the segment (a) represents the proximal segment that narrows and converges at the proximal end 2 and where the coupler elements end. Segment (b) is a fastener segment that lies on the wall of the adductor container Z and has relatively narrow meshes 3 . Segment (c) is permeable with other meshes 4 through which the blood stream can exit to the branched X and Y containers. Segment (d) is widened in front of segment (d) and here also in front of segment (c) and becomes positioned in aneurysm A. The ends of the different wires are atraumatically deformed by means of marker spirals 8 of an impermeable material X-rays, such as possibly platinum or a platinum alloy. Between segments (c) and (d) there is a fiber structure 6 which, for example, can be produced from nylon and which simultaneously represents the separation zone T1. Reference number 5 designates meshes, i.e. filaments that flare out to the outside of implant 1 in the distal area.
    [00047] Figure 5 shows as a basic sketch four variants of the conformation of the distal area 5 of implant 1 according to the invention. Figure 5a shows a distal end of the implant that widens in the shape of a trumpet, i.e. segment (d) widens in the shape of a cup. According to figure 5b, the distal end 5 is widened in a discoidal shape (d) with a rather narrow distal segment 5. Figure 5c shows a combination of elements from figure 5a and 5b.
    [00048] Figure 5d finally shows a distal area with curled distal ends of the different filaments of an implant 1. For orientation, in figure 5a, that is, 5b, the segments (a), (b) and (c) are drawn. .
    [00049] Figure 6 shows in extended spatial form a preferred embodiment of an implant 1 according to the invention with segments (a) to (d). The implant 1 must also be understood as a mesh structure cut from a nitinol tube, and in the presentation the dashed threads 11 correspond to the threads stretched on the opposite side. The enlarged hives in the region of the segment (c) in the presentation of figure 6a can be clearly seen, as well as the widening in the form of a chalice or trumpet in the main sketch in accordance with figure 6b. The separation zone T1 with separation elements in the form of a contracted plane of nylon 6 is also shown there.
    [00050] Figure 7 shows another embodiment of an implant 1 according to the invention cut from a nitinol tube with the foreseen proximal coupler elements 10, a segment (a) that narrows in a proximal direction, a fixation segment ( d), the segment with the largest mesh width (c) and the segment (d) that widens. The implant is also presented here in spatial form, corresponding to Figure 6 and has the specificity that the T1 separation zone consists of the cut-out elements of the nitinol tube that in deformation bend inwards, while the distal end widens to out in the shape of a trumpet. The threads folded into the separation zone T1 serve, as in the variant of figure 6, the inserted nylon threads for retaining occlusion means introduced into the aneurysm.
    [00051] The implants according to figures 6 and 7 do not need to have a tubular-shaped structure, however, they can also be provided as rolled "mats" that apply against the wall of the container. A partial crack formation is also possible.
    [00052] Figure 8 shows an implant 1 according to the invention with a discoidal-shaped conformation of the segment (d), which essentially consists of wire loops 12. The wire loops follow the cylindrical part of the implant body 1 , this cylindrical part being formed by segments (a) to (c). In the transition area with the loops 12 applied, there are marking elements 8 which serve for secure positioning. In the area of this connection of the cylindrical body of the implant 1 and the segment (d) with the loops 12 is the segment (c) which allows the inflowing blood to exit to lateral flow vessels. The blood therefore penetrates between the threads with the marker elements 8 in the outgoing vessels (X and Y, figure 2).
    [00053] Different variants of the distal segment (d) are shown in the top view in figure 8d up to 8g and individual or multiple loops 12 can be provided with marking spirals 13. The marking spirals 13 can enclose the loops in whole or in part. In the case shown, the loops start from four joining threads 15 that also hold the marker elements 8, and in the presentations from 9b to 9g, the inner circle 14 represents the transition to the cylindrical part of the implant. Any existing extensions of a separation zone T1 or T2 are not shown.
    [00054] The embodiments according to figure 8f and g show with a diaphragm 16 ductile loops 12 there revised which, in this case, simultaneously form a separation zone T2, as shown in figure 3.
    [00055] It is understood that the T1 and T2 separation zones need to divide the segment to be occluded from the aneurysm A. According to the type of aneurysm this separation zone will be located in the entrance area - in the case of branched vessels that are they extend close to the entrance area - or inside the aneurysm - when two vessels branch directly from the aneurysm area - and in the latter hypothesis only the part of the aneurysm free of branched vessels can be subjected to occlusion. Especially in the discoidally shaped distal segments d of the implants according to the invention - especially in the case of a larger number of wire loops - an additional attachment to the arrangement of separating elements cut from the tube may be unnecessary.
    [00056] The loop-shaped distal segments (d) shown in figure 8 can, on the one hand, as well as the remaining part of the implant body, be cut from a tube with a suitable diameter. But it is also possible that segments (a) to (c) of the implant body are cut from a tube in the conventional way and segment (d) would be stapled from wire filaments, for example, by laser welding.
    [00057] Figure 9 presents the special case of an A aneurysm in which the X and Y branched vessels exit the aneurysm itself. The implants 1 shown in figure 8 are particularly suitable for this hypothesis, in which the loops 12 simultaneously form the separation zone T2 which is disposed in the distal aneurysm of the branched vessels itself. The cylindrical body of implant 1 with segments (a) and (b) is located in the adductor vessel Z, the segment (c), which allows the passage of blood to the X and Y branches, is located in the area of this branch and of Indirectly away from this segment (c) is the segment (d) with the loops 12. The loops can be covered with a diaphragm, this diaphragm being made of ductile material, for example, teflon or a fiber fleece . A fiber fleece of this type of polycarbonateethane is known from DE 28 06 030 and stands out for its high elasticity, which is favorable for applying the implant through the catheter. The diaphragm can be split, folded or porous, for example, also to save material and to facilitate transport by a catheter.
    [00058] A diaphragm of this type can also be used as a separating element for the separation zone, as it is arranged between segments (c) and (d).
    [00059] Figure 10 shows in extended spatial form several preferred embodiments of an implant 1 according to the invention, in which the beehive structure is formed essentially of the same size and in a heated shape; only the distal loops have a larger hive surface.
    [00060] As in figure 6, the threads 11 shown in broken lines correspond to the threads stretched on the opposite side. Implant 1 corresponds to a tube with a grid or honeycomb structure.
    [00061] The proximal coupler element 10 is followed by the proximal segment (a) of the fastener segment (b). This distal segment (d) begins in the area of the eyelets 17 which serve to receive and secure wire or nylon elements with which the implant is pulled into a separation zone. The distal loops in the segments (d) which flare outwards also have distal shoulders which have proved to be advantageous when introducing the implant through a catheter at the site of use.
    [00062] Figure 10b corresponds in all essential posts to the representation of figure 10a, except for a partial crack in the area of arrows 19 where the implant tube structure 1 is not closed. The cut extends axially parallel and ends in front of the distal segment (d), where the permeable segment (c) is located.
    [00063] Figure 10c presents a variant with a slot 19 of parallel non-axial projection that projects around the longitudinal axis, but ends in front of the distal segment (d).
    [00064] These slits have shown to be expressly advantageous for flexibility in the region of the fixation zone (b). The radial force of the implant 1 thus essentially unaffected, however, improves the adequacy of the vessel tracing and vessel lumen.
    [00065] Figure 10d also shows an implant according to the invention with a slit, however, the slit does not extend to the edges of the implant.
    [00066] Figure 10e presents another variant with a slit 19 that also wraps around a longitudinal axis, although beehive shapes exist side by side. Beehive shape has an influence on flexibility and can be selected according to needs.
    [00067] The loops, that is, beehives of the distal segment (d) are designated in figure 10 with the reference number 12.
    [00068] Figure 11 shows another variant of an implant 1 of the invention with a single coupling element 10 and an essentially regular honeycomb structure, in which additional loops 20 are provided as separating elements. In this sense, the embodiment of figure 11 corresponds to an embodiment of figure 7. The additional loops 20 in the implanted product are turned inwards and form the dividing plane T1. These loops 20 also have shoulders 18 that facilitate transport by a catheter.
    [00069] Figure 11b schematically shows the implant of figure 11a with the loops 20 facing inwards and the dividing plane T1.
    [00070] Figure 12 shows another variant of an implant 1 especially flexible with articulated connectors 21 in the form of a zigzag conduction of the corresponding threads to improve the suitability of the implant 1 in curved vessels in the area of the bifurcation.
    [00071] Figure 3 shows, finally, another variant, in which, in segment (b), a part of the hives is formed with thinner fillets (W area), in order to increase flexibility and bending capacity. This area 22 is located in an attachment zone (b) and must act in case of an uneven projection of a vessel in the attachment zone. In the rest, implant 1 corresponds to the variants presented above.
    权利要求:
    Claims (10)
    [0001]
    1. Implant (1) to be used in the occlusion of bifurcated aneurysms (A), with a mesh structure (3, 4), the implant comprises, from proximal to distal, segments (a) to (d), (a) being a proximally narrowing segment in which the mesh structure (3, 4) is joined to form one or more coupler elements (10); (b) being a fastener segment by which the implant (1) can be supported on the wall of a vessel; (c) being a permeable segment to a region of the vessel bifurcation and; (d) being a distal segment in which the implant (1) is expanded in relation to the segment (b), and which is intended for positioning in the aneurysm (A), with a separation zone (T1) being arranged between segments (c) and (d), the separation zone (T1) being provided with separating elements consisting of filaments (6) extending in a plane transversely to the implant (1), characterized by the fact that the distal segment (d) consists of a plurality of loops (12), wherein and the distal segment (d) is widened in the form of a trumpet or basket shape by a braid or by means of loops (12), and the loops (12), in the distal segment (d), are provided with shoulders (18 ) rounded and atraumatic at the distal end.
    [0002]
    2. Implant according to claim 1, characterized in that it consists of material with shape memory effect.
    [0003]
    3. Implant according to claim 1, characterized in that the implant (1) is cut from a tube.
    [0004]
    4. Implant according to claim 1, characterized in that the proximal segment (a) ends in a coupler wire (10).
    [0005]
    5. Implant according to claim 1, characterized in that the distal segment (d) is designed to be atraumatic, soft and elastic.
    [0006]
    6. Implant according to claim 1, characterized in that the loops (12) are provided with eyelets (17) in the distal segment (d).
    [0007]
    7. Implant according to claim 1, characterized in that it has a laterally closed tubular design.
    [0008]
    8. Implant according to claim 1, characterized in that the implant (1) is partially or continuously split.
    [0009]
    9. Implant according to claim 1, characterized in that marker elements (8) are arranged in the distal segment (d).
    [0010]
    10. Implant according to claim 1, characterized in that it is coupled to a conducting wire (9).
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    KR101843219B1|2018-05-14|
    CN103491886A|2014-01-01|
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    法律状态:
    2018-12-18| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-10-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-09-01| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2021-02-02| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2021-06-15| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-24| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/02/2012, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102011011869.1|2011-02-22|
    DE102011011869A|DE102011011869A1|2011-02-22|2011-02-22|implant|
    PCT/EP2012/000772|WO2012113554A1|2011-02-22|2012-02-22|Implant, especially for the occlusion of bifurcation aneurysms|
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