• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    automatic injection devices that have overmolded grip surfaces. the exemplary embodiments provide automatic injection devices, housing components for the automatic injection devices, and methods for manufacturing the same. an exemplary housing of an automatic injection device may be overmolded with one or more gripping surfaces to facilitate gripping and manipulation of the automatic injection device by a user upon performance of an injection. in an exemplary embodiment, an overmolded left grip surface may extend along a left side of the housing and an overmolded right grip surface may extend along a right side of the housing opposite the left side.
    公开号:BR112013018905B1
    申请号:R112013018905-3
    申请日:2012-01-24
    公开日:2021-07-13
    发明作者:Joseph F. Julian；Chuan Li；Aaron B. Eiger；Mark Kurth；Sabrina Katz；Adam Callif；James C. Stango
    申请人:Abbvie Biotechnology Ltd；
    IPC主号:
    专利说明:

    Related Orders
    [001] This application is non-provisional and claims priority to provisional patent application No. US61/435,465, filed January 24, 2011, the contents of which are expressly incorporated herein by reference in their entirety. Background
    [002]Automatic injection devices offer an alternative to manually operated syringes to deliver therapeutic agents into patients' bodies and allow patients to self-administer therapeutic agents. Automatic injection devices can be used to administer medications under emergency conditions, for example, to administer epinephrine to counteract the effects of a severe allergic reaction. Automatic injection devices have also been described for use in administering antiarrhythmia medications and selective thrombolytic agents during a heart attack. See, for example, patents nos. US3,910,260; US4,004,577; US4,689.042; US 4,755,169; and US4,795,433, the contents of which are incorporated in the present invention without their entirety by way of reference. Various types of automatic injection devices are also described, for example, in patents US3,941,130; US4,261,358; US5,085,642; US5,092,843; US5,102,393; US5,267,963; US6,149,626; US6,270,479; and US6,371,939 and in international patent publication No. WO/2008/005315, the contents of which are incorporated in the present invention without its entirety by way of reference.
    [003] Conventionally, an automatic injection device houses a syringe and, when operated, causes the syringe to move forward and a needle to protect the housing so that a therapeutic agent contained in the syringe is ejected into a patient's body . summary
    [004]Exemplary embodiments provide automatic injection devices, housing components for automatic injection devices, and methods for fabricating the same. An exemplary housing of an automatic injection device may be overmolded with one or more gripping surfaces to facilitate gripping and manipulation of the automatic injection device by a user upon performance of an injection. In an exemplary embodiment, an overmolded left grip surface may extend along a left side of the housing and an overmolded right grip surface may extend along a right side of the housing opposite the left side.
    [005] According to an exemplary embodiment, an automatic injection device is provided with a housing that surrounds a cavity to accommodate a container. A first overmolded grip surface is provided to extend longitudinally along a portion of the housing on a first outer surface of the housing. A second overmolded grip surface is provided to extend longitudinally along a portion of the housing on a second outer surface of the housing opposite the first outer surface.
    [006] In an exemplary embodiment, the first and second overmolded grip surfaces in the housing are formed of a first material that has a first sense of touch and the non-handle surfaces in the housing are formed of a second material that has a second sense of touch. Touch. In an exemplary embodiment, the first and second overmolded grip surfaces on the housing are formed of a first material that has a first hardness and the gripless surfaces on the housing are formed of a second material that has a higher second hardness.
    [007] In an exemplary embodiment, the automatic injection device includes a removable distal cap to protectively cover an injection needle attachable to the container, an outer surface of the distal cap that includes an overmolded handle surface to facilitate gripping and removal of the Distal cap. In an exemplary embodiment, the automatic injection device includes a trigger button that projects from an opening in the housing and that includes an overmolded contact surface to facilitate actuation of the trigger button by a user. In an exemplary embodiment, the automatic injection device includes a proximal end end to cover a proximal end of the automatic injection device, wherein the proximal end end has an overmolded outer surface. In an exemplary embodiment, a proximal end end top surface includes a recessed surface to direct and facilitate accommodation of a user's hand or finger to grip the automatic injection device.
    [008] According to another exemplary embodiment, a method is provided to assemble an automatic injection device. The method includes providing a housing that surrounds a cavity to accommodate a container. The method includes overmolding, in the housing, a first handle surface that extends longitudinally along a portion of the housing to a first outer surface of the housing. The method also includes overmolding, in the housing, a second handle surface that extends longitudinally along a portion of the housing on a second outer surface of the housing opposite the first outer surface.
    [009] In an exemplary embodiment, the first and second surfaces of handles in the housing are formed of a first material that has a first sense of touch and the surfaces without a handle in the housing are formed of a second material that has a second sense of touch . In an exemplary embodiment, the first and second surfaces of handles in the housing are formed of a first material that has a first hardness and the non-handle surfaces in the housing are formed of a second material that has a second higher hardness.
    [0010] In an exemplary embodiment, the method includes overmolding a grip surface on an outer surface of a distal cap to facilitate gripping and removal of the distal cap and attaching the distal cap to a distal end of the housing to protectively cover a needle of injection. In an exemplary embodiment, the method includes overmolding a grip surface on a fire button to facilitate activation of the fire button and providing the fire button within the cavity so that part of the fire button protrudes from an opening. in the accommodation.
    [0011] In an exemplary embodiment, the method includes overmolding a grip surface on an outer surface of a proximal end end and coupling the proximal end end to a proximal end of the housing. In an exemplary embodiment, a proximal end end top surface includes a recessed surface for directing a user's hand or finger to grasp the automatic injection device.
    [0012] According to another exemplary embodiment, an automatic injection device is provided that includes a housing that surrounds a cavity to accommodate a container. The housing includes a first overmolded handle region, a second overmolded handle region and a recessed region flush with the first and second overmolded handle regions.
    [0013] In an exemplary embodiment, the recessed region is disposed between the first and second overmolded handle regions. In an exemplary embodiment, a housing width in the recessed region is less than a housing width in the first overmolded handle region and a housing width in the second overmolded handle region. In an exemplary embodiment, the recessed region lacks a grip surface.
    [0014] In an exemplary embodiment, the first overmolded handle region is formed by a proximal end end of the housing that has an outer surface that is overmolded with a handle surface. In an exemplary embodiment, the second overmolded handle region of the housing has a tapered tubular structure. Brief Description of Drawings
    [0015] The objectives, aspects, features and advantages mentioned above and others of the exemplary modalities will become more evident and can be better understood by referring to the following description taken in conjunction with the attached drawings, in which:
    [0016] Figure 1 is a left side perspective view illustrating an exemplary automatic injection device in which a removable distal cap is removed and portrayed separately from the device housing.
    [0017] Figure 2 is a right side perspective view illustrating the exemplary automatic injection device of Figure 1.
    [0018] Figure 3 is an exploded perspective view from the left side of the exemplary automatic injection device of Figures 1 and 2.
    [0019] Figure 4 is a front view of the exemplary automatic injection device of Figures 1 to 3.
    [0020] Figure 5 is a left side view of the exemplary automatic injection device of Figures 1 to 3, in which the right side view is a mirror image of the left side view.
    [0021] Figure 6A is a front close-up view of an exemplary left-hand grip surface provided on a first body portion of the device of Figures 1 to 3.
    [0022] Figure 6B is a left side close-up view of the exemplary left grip surface of Figure 6A.
    [0023] Figure 7 is a bottom view of an exemplary removable distal cap of the exemplary automatic injection device of Figures 1 to 3.
    [0024] Figure 8 is a top view of an exemplary proximal end end of the exemplary automatic injection device of Figures 1 to 3.
    [0025] Figure 9 is a flowchart of an exemplary method for forming an exemplary automatic injection device. Detailed Description
    [0026]Exemplary embodiments provide automatic injection devices that have housings that are particularly designed and configured for reliable, safe, ergonomic and comfortable handling by users. Exemplary modalities also provide housing components for automatic injection devices that are particularly designed and configured for reliable, safe, ergonomic and comfortable handling by users. Exemplary embodiments also provide methods for fabricating example housings for automatic injection devices and automatic injection devices that include exemplary housings.
    [0027] In an exemplary embodiment, one or more overmolded grip surfaces may be provided on an outer surface of an exemplary automatic injection device housing to allow the device to be easily, comfortably and reliably picked up and handled by a user . The exemplary overmolded grip surfaces are particularly configured and positioned in the housing to prevent the user's hands from slipping and thereby to prevent injury to the user and others in close proximity. Additionally, the exemplary overmolded grip surfaces are particularly configured and positioned to be ergonomic and comfortable for use, particularly by physically weak users, eg, older users, users suffering from rheumatoid arthritis and the like.
    [0028]In user tests performed using exemplary automatic injection devices, test participants observed exemplary overmolded grip surfaces on the sides of the devices and the relatively large ergonomically shaped and sized device. Test participants provided high ratings for handling and gripping of exemplary devices, with overmolded gripping surfaces being the primary factor in test participants' high ratings of exemplary device configurations for handling and gripping, compared to devices without gripping surfaces. handles overmolded. For several utility factors, there was a significant positive correlation between Cochin scores and the sample device configurations, indicating that the sample devices are well suited for use by users with manual impairment.
    [0029] An exemplary automated injection device can contain and can be used to administer a dose of a TNFα inhibitor. In an exemplary embodiment, the TNFα inhibitor may be a human TNFα antibody or antigen-binding portion thereof. In an exemplary embodiment, the human TNFα antibody or antigen-binding portion thereof can be adalimumab (HUMIRA®) or golimumab. I. Definitions
    [0030]Certain terms are defined in this section to facilitate understanding of the exemplary modalities.
    [0031] The terms "automatic injection device" and "autoinjector" as used in the present invention refer to a device that allows a patient to self-administer a therapeutically effective dose of a therapeutic agent, wherein the device differs from a syringe conventional by the inclusion of a mechanism to automatically deliver the therapeutic agent to the patient via injection when the mechanism is engaged.
    [0032] The terms "vessel" and "container" as used in the present invention refer to a syringe or cartridge that can be used in an exemplary automatic injection device to contain a dose of a therapeutic agent.
    [0033] The terms "syringe" and "cartridge" as used in the present invention refer to a sterile barrel portion of an automatic injection device that is filled with a dose of a therapeutic agent prior to distribution or sale of the device to a patient or other non-medical professional for administering the therapeutic agent to a patient. In an exemplary embodiment, a distal end of the barrel portion of a syringe can be attached to a sterile hypodermic injection needle. In an exemplary embodiment, a distal end of the barrel portion of a cartridge may not be attached to an injection needle. That is, in exemplary embodiments, a syringe may be a cartridge with a prefixed injection needle attached to its barrel portion.
    [0034] The exemplary embodiments described in the present invention with reference to a syringe assembly may also be deployed using a cartridge assembly. Similarly, the exemplary embodiments described in the present invention with reference to a cartridge assembly may also be implemented using a syringe assembly.
    [0035] The term "pre-filled syringe" as used in the present invention refers to a syringe that is filled with a therapeutic agent immediately prior to administration of the therapeutic agent to a patient and a syringe that is filled with a therapeutic agent and stored in this pre-filled form for a period of time prior to administering the therapeutic agent to a patient.
    [0036] The terms "injection needle" and "needle" as used in the present invention refer to a needle in an automatic injection device that is inserted into a patient's body to deliver a dose of a therapeutic agent to the body of the patient. In an exemplary embodiment, the injection needle may be directly coupled to or may otherwise be in contact with a syringe assembly or a cartridge assembly that contains a dose of the therapeutic agent. In another exemplary embodiment, the injection needle may be indirectly coupled to the syringe or cartridge assembly, for example, via a syringe needle and/or transfer mechanism that provides fluid communication between the syringe or cartridge assembly and the injection needle.
    [0037] The term "pre-injection state", as used in the present invention, refers to a state of an automatic injection device prior to device activation, that is, prior to the start of delivery of a therapeutic agent contained in the device.
    [0038] The term "injection state" as used in the present invention refers to one or more states of an automatic injection device during delivery of a therapeutic agent contained in the device.
    [0039] The term "post-injection state" as used in the present invention refers to the completion of delivery of a therapeutically effective dose of a therapeutic agent contained in the device or removal of the device from the patient prior to completion of delivery of a therapeutically effective dose of the therapeutic agent.
    [0040] An automatic injection device provided in accordance with exemplary embodiments may include a "therapeutically effective amount" or a "prophylactically effective amount" of an antibody or antibody portion of the invention. A "therapeutically effective amount" as used in the present invention refers to an amount effective, in dosages and for periods of time necessary, to achieve the desired therapeutic result. A therapeutically effective amount of the antibody, antibody portion or other TNFα inhibitor may vary according to factors such as the patient's disease state, age, sex and weight and the ability of the antibody, antibody portion or other TNFα inhibitor imply a desired response in the patient. A therapeutically effective amount is also one in which any toxic or detrimental effects of the antibody, antibody portion or other TNFα inhibitor are resolved by the therapeutically beneficial effects. A "prophylactically effective amount" as used in the present invention refers to an amount effective, in dosages and for periods of time necessary, to achieve the desired prophylactic result. Typically, since a prophylactic dose is used in patients prior to or at an earlier stage of disease, the prophylactically effective amount will be less than the therapeutically effective amount.
    [0041] The terms "substance" and "therapeutic agent", as used in the present invention, refer to any type of drug, biologically active agent, biological substance, chemical substance or biochemical substance that is capable of being administered in a therapeutically amount effective to a patient employing the exemplary automatic injection devices. Exemplary therapeutic agents useful in the exemplary automatic injection devices can include, but are limited to, agents in a liquid state. Such agents may include, but are not limited to, adalimumab (HUMIRA®) and proteins that are in a liquid solution, for example, fusion proteins and enzymes. Examples of proteins in solution include, but are not limited to, Pulmozyme (Dornase alfa), Regranex (Becaplermin), Activase (Alteplase), Aldurazyme (Laronidase), Amevive (Alefacept), Aranesp (Darbepoetin alfa), Becaplermin Concentrate, Betaseron (Interferon beta-1b), BOTOX (Botulinum Toxin Type One), Elitek (Rasburicase), Elspar (Asparaginase), Epogen (Epoetin alfa), Enbrel (Etanercept), Fabrazime (Agalsidase beta), Infergen (Interferon alfacon-1) , Intron UM (Interferon alfa-2a), Kineret (Anakinra), MYOBLOC (Botulinum Toxin Type B), Neulasta (Pegfilgrastim), Neumega (Oprelvekin), Neupogen (Filgrastim), Otak (Denileucine diftitox), PEGASYS (Peginterferon alfa-2a ), Proleukin (Aldesleucine), Pulmozyme (Dornase alfa), Rebif (Interferon beta-1a), Regranex (Becaplermin), Retavase (Reteplase), Roferon-UM (Interferon alpha-2), TNKase (Tenecteplase), and Xigris (Drotrecogin alpha), Arcalyst (Rilonacept), NPlate (Romiplostim), Mircera (methoxypolyethylene glycol-epoetin beta), Cinryze (i C1 esterase inhibitor, Elaprase (idursulfase), Myozyme (alglucosidase alfa), Orencia (abatacept), Naglazime (galsulfase), Kepivance (palifermin) and Actimmune (interferon gamma-1b).
    [0042] The term "dose" or "dosage" as used in the present invention refers to an amount of a therapeutic agent, such as a TNFα inhibitor, that is administered to a patient preferably using the device. usable automatic injection of the invention. In one embodiment, the dose comprises an effective amount, for example, including, but not limited to, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg, 80mg, 90mg, 100mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, and 160 mg, of the TNFα inhibitor adalimumab.
    The term "dosage" as used in the present invention refers to the administration of a therapeutic agent (eg an anti-TNFα antibody) to achieve a therapeutic goal (eg treating rheumatoid arthritis).
    [0044] The term "dosing regimen" as used in the present invention refers to a treatment schedule for a therapeutic agent, such as a TNFα inhibitor, for example, a treatment schedule for an extended period of time and /or yield from the course of treatment, e.g. administering a first dose of a TNFα inhibitor by week 0 followed by a second dose of a TNFα inhibitor in a biweekly dosing regimen.
    [0045] The term "treatment" as used in the present invention refers to therapeutic treatment, as well as suppressive or prophylactic measures, for the treatment of a disorder, such as a disorder in which TNFα is harmful, for example, rheumatoid arthritis .
    [0046] The term "patient" or "user", as used in the present invention, refers to any type of animal, human or non-human, that can be administered as a therapeutic agent with the use of exemplary automatic injection devices.
    [0047] The term "proximal" refers to a portion, end or component of an exemplary automatic injection device that is furthest away from an injection site on a patient's body when the device is held against the patient for an injection or to mimic an injection.
    [0048] The term "distal" refers to a portion, end or component of an exemplary automatic injection device that is closest to an injection site on a patient's body when the device is held against the patient for an injection or to mimic an injection.
    [0049] The term "planar" is used in the present invention, in a broad disposition sense, to mean exactly planar or approximately planar within some tolerance of exactly planar.
    [0050] The term "concave" is used in the present invention, in a broad disposition sense, to mean exactly concave or approximately concave within some tolerance of exactly concave.
    [0051] The term "convex" is used in the present invention, in a broad disposition sense, to mean exactly convex or approximately convex within some tolerance of exactly convex.
    [0052] The term "elliptical" is used in the present invention, in a broad array sense, to mean exactly elliptical or approximately elliptical within some tolerance of exactly elliptical.
    [0053] The term "oval" is used in the present invention, in a broadly disposition sense, to mean exactly oval or approximately oval within some tolerance of exactly oval.
    [0054] The term "rectangular" is used in the present invention, in a broad array sense, to mean exactly rectangular or approximately rectangular within some tolerance of exactly rectangular.
    [0055] The term "parallel" is used in the present invention, in a broad disposition sense, to mean exactly parallel or approximately parallel within some tolerance of exactly parallel.
    [0056] The term "linear" is used in the present invention, in a broad disposition sense, to mean exactly linear or approximately linear within some tolerance of exactly linear.
    [0057] The term "equal" is used in the present invention, in a broadly disposition sense, to mean exactly equal or approximately equal within some tolerance.
    [0058] The term "adjacent" is used in the present invention, in a broad disposition sense, to mean immediately adjacent or approximately adjacent within some tolerance.
    [0059] The term "level" is used in the present invention, in a broad disposition sense, to mean immediately level with or approximately level with within some tolerance.
    [0060] The term "transverse axis" is used in the present invention to refer to a geometric axis that is substantially perpendicular to a longitudinal axis. II. Exemplary modalities
    [0061] Exemplary embodiments are described below with reference to certain illustrative embodiments. Although exemplary modalities are described in relation to the use of an automatic injection device to provide an injection of a dose of a therapeutic agent, an element of common knowledge in the art will recognize that exemplary modalities are not limited to illustrative modalities and that exemplary automatic injection devices can be used to inject any suitable therapeutic agent into a patient. Furthermore, the components of exemplary automatic injection devices and the methods of making and using the exemplary automatic injection devices are not limited to the illustrative embodiments described below.
    [0062] Figures 1 to 8 illustrate an exemplary automatic injection device 100 that has one or more overmolded grip surfaces to facilitate gripping and handling of the device. The Figures indicate a longitudinal axis L that operates substantially along the length of the device 100, a first transverse axis H that operates substantially perpendicular to the longitudinal axis L of the device, and a second transverse axis V that operates substantially perpendicular to both the axis. longitudinal geometric axis L with respect to the first transverse geometric axis H.
    [0063] In some exemplary embodiments, a length of the exemplary device 100 may be about 4, 4.5, 4.8, 5, 5.5, 6, 6.5, 6.6, 6.7, 6, 8, 6.9, 7, 7.5, 8, 8.5, 9, 9.5, 10 inches, but is not limited to these exemplary lengths. In some exemplary embodiments, an exemplary width of device 100 (at its widest location) may be about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0 inches, but not limited to these exemplary widths. In some exemplary embodiments, an exemplary thickness of device 100 (at its thickest location) may be about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.11, 1.12, 1.13, 1.14, 1.15, 1.16, 1.17, 1.18, 1, 19, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2, 4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0 inches, but is not limited to these exemplary thicknesses. In an exemplary embodiment, device 100 may have an exemplary length of about 6.69 inches, an exemplary width of about 1.46 inches at the widest portion, and an exemplary thickness of about 1.15 inches at the thickest portion. . In another exemplary embodiment, device 100 may have an exemplary length of about 4.8 inches, an exemplary width of about 0.8 inches at the widest portion, and an exemplary thickness of about 0.6 inches at the widest portion. thick. The exemplary dimensions of the mentioned exemplary devices allow the device to be comfortable and ergonomically held in the user's one-hand grip. This allows a user to reliably and comfortably pick up and handle the device in order to perform an injection.
    [0064] The exemplary automatic injection device 100 may include an external housing 101 for housing a container, such as a syringe or cartridge. The container may be pre-filled with a dose of a therapeutic agent to be injected into a patient's body. The device housing 101, in its assembled form, can be of any size and shape suitable for storing and dispensing the dose of therapeutic agent. The assembled housing 101 may have a shape that is designed and configured to be comfortable for a user's hand and so that the user can comfortably and reliably hold device 100 during an injection. In an exemplary embodiment, the assembled housing 101 may have an elongated structure such that its length taken along the longitudinal axis L is much greater than its width taken along the first transverse axis H and its thickness taken along a second transverse geometric axis V. An exemplary ratio of length to width (at the widest location) of the device may be, but is not limited to, 2:1, 3:1, 4:1, 5:1, 6:1 , 7:1, 8:1, 9:1, 10:1, all intermediate ratios, and the like. An exemplary ratio of length to thickness (in the thickest location) of the device can be, but is not limited to, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8 :1, 9:1, 10:1, all intermediate ratios, and the like.
    [0065] Figure 1 is a left side perspective view illustrating an exemplary automatic injection device 100 that has an outer housing 101. Figure 2 is a right side perspective view of the example automatic injection device 100 of Figure 1. In an exemplary embodiment, housing 101 of device 100 may have a tapered tubular structure with a substantially elliptical or oval cross-section. In the tapered tubular structure, the width of the housing 101 may be greater at a proximal portion 106 of the housing 101 than at a distal portion 104 of the housing 101. The tapered, tubular shape of the exemplary housing allows the device to be functional and to be comfortable and ergonomically. held and manipulated by a user's hand.
    [0066] The housing 101 of the device 100 can be formed from a plurality of body components that are assembled together. In an exemplary embodiment, housing 101 may be formed from a first body portion 116 and a second body portion 118 which, when cooperatively engaged with each other along their peripheral edges, surround and provide a cavity therebetween. The first and second body portions may be cooperatively engaged with each other using any suitable technique including, but not limited to, bonding, gluing, ultrasonic welding, friction fit, snap fit, interference fit, threads, attachment between corresponding protuberances and recesses and the like. One element of common knowledge in the art will recognize that, in other exemplary embodiments, the device cavity may be enclosed in a single body component or three or more body components when assembled together.
    [0067] A firing button 120 can extend from a surface of the first body portion 116. The firing button 120, when activated by a user, can cause an injection to be performed by device 100. In one mode For example, a recessed or concave portion 126 may be provided on the first body portion 116 flush with the fire button 120 to facilitate activation of the fire button 120. The recessed portion 126 may surround the fire button 120 in an exemplary embodiment to accommodate a user's finger as the user presses the fire button 120.
    [0068] A transparent inspection window 128 may be provided on a surface of the first body portion 116 to allow a user to view the contents of the device 100. The transparent inspection window 128 may allow the user to view a therapeutic agent contained therein. device 100, for example, to ensure agent clarity and to visualize an end of injection indicator that materializes at the end of an unsuccessful injection. An exemplary viewport 128 may be substantially elongated in shape, for example, an elongated rectangle (with sharp or rounded edges), an elongated elliptical shape, and the like, although other shapes are possible. In the elongated viewport 128, the length extending along the longitudinal axis L may be substantially greater than the width extending along the first transverse geometric axis H. In exemplary embodiments, a ratio of length to width inspection window may include, but is not limited to, 1.5:1, 2.0:1, 2.5:1, 3.0:1, 3.5:1, 4.0:1, 4 .5:1, 5:1, all intermediate ratios, and the like.
    [0069] A proximal end end 172 of the housing device may be provided to cover the proximal end of the device 100. In an exemplary embodiment, the proximal end end 172 may be coupled to the proximal end of the assembled first and second body portions. The proximal end end 172 may be of any suitable size and shape. In an exemplary embodiment, the proximal end end 172 may have a substantially tubular configuration with a substantially oval or elliptical shape. In an exemplary embodiment, at least part of the outer surface of the proximal end end 172 may be overmolded with one or more grip surfaces 173 to facilitate gripping the proximal portion of the device. In an exemplary embodiment, the entire outer surface of the proximal end end 172 may be covered by an overmolded handle surface 173. Corresponding recesses may be provided on the outer surface of the proximal end end 172 to accommodate the handle surfaces.
    [0070] A removable distal cap 164 can be coupled to the distal end of the first and second body portions mounted to cover the distal end of device 100 to prevent exposure of the injection needle prior to an injection. Distal cap 164 protects against accidental and/or unwanted contact by a user with the injection needle. Distal cap 164 also protects against damage and contamination of the injection needle when the device is not in use. Distal cap 164 can adopt any suitable size and shape. In an exemplary embodiment, the distal cap 164 may have a substantially tubular configuration with a substantially oval or elliptical shape. In an exemplary embodiment, a front surface of the distal cap 164 may have a concave cutting portion 168 to accommodate part of the inspection window 128.
    [0071] In an exemplary embodiment, the outer surface of the distal cap 164 may lack overmolded grip surfaces. In other exemplary embodiments, the outer surface of the distal cap 164 may be overmolded with one or more handle surfaces 165 to facilitate handling and removal of the distal cap 164 from the device. In an exemplary embodiment, the entire outer surface of the distal cap 164 may be covered by an overmolded handle surface 165. Corresponding recesses may be provided on the outer surface of the distal cap 164 to accommodate the handle surfaces.
    [0072] In an exemplary embodiment, one or more ridges (which protrude from the outer surface) and/or one or more grooves or holes (which are lowered into the outer surface) may be provided on the grip surfaces 165 on the distal cap 164 to further facilitate handling and handling of the device. The shapes and locations of the ridges and/or grooves can be changed as desired and any desired number of ridges and/or grooves can be provided. In an exemplary embodiment, the ridges and/or grooves may extend substantially perpendicularly to the longitudinal geometric axis L of the device. In an exemplary embodiment, grip surfaces 165 may include textured surfaces to enhance tactile feel and further facilitate firm gripping of the device. In an exemplary embodiment, distal cap 164 may include one or more protrusions 170a, 170b (shown in Figure 5) that extend outwardly from the front surface and return to the surface of distal cap 164 to further facilitate gripping of cap 164.
    [0073] In an exemplary embodiment, the distal cap 164 may frictionally engage a recessed or protruded portion of the housing in order to be retained in position in the housing when the device is not in use. In an exemplary embodiment, the distal cap 164 may include a protrusion to lock and/or attach the cap to the housing until the user is ready to perform an injection. Any suitable marriage mechanism can be used according to the teachings of exemplary modalities.
    [0074] When the proximal end end 172, the first body portion 116 and the second body portion 118 are assembled together, they form a tapered tubular structure. The side surfaces of the body portions 116, 118 flush with the handle surfaces 173 at the proximal end end 172 may include one or more recessed or concave portions 122, 124. In an exemplary embodiment, two recessed portions 122, 124 may be provided at opposite sides of the device flush with the trigger button 120. The recessed portions allow the user's hand to be accommodated in a comfortable position when pressing the trigger button 120.
    [0075] A portion of the body portions 116, 118 flush with the recessed portions 122, 124 may be overmolded with one or more grip surfaces 154, 156 to facilitate gripping and handling of the device. In an exemplary embodiment, two grip surfaces 154, 156 may be provided on surfaces on opposite sides of the device. A first handle surface 154 may be flush with a first recessed portion 122 and second handle surfaces 156 may be flush with a second recessed portion 124. Corresponding recesses may be provided on the outer surface of the first body portion 116 to accommodate the grip surfaces.
    [0076] In an exemplary housing for an automatic injection device, a first overmolded handle region, a second overmolded handle region, and a recessed region flush with the first and second overmolded handle regions can be provided. The first overmolded grip region, the second overmolded grip region and the recessed region can cooperatively provide an ergonomic and comfortable grip area in which a user can grip the automatic injection device in order to perform an injection.
    [0077] In this exemplary embodiment, the first overmolded handle region may be formed by the proximal end end 172 having an overmolded outer surface or cover. The second overmolded handle region may be formed part of the assembly of the first body portion 116 and the second body portion 118 having one or more overmolded handle surfaces (e.g., handle surfaces 154, 156). In an exemplary embodiment, the second overmolded handle region may have a substantially tubular tapered structure to provide an ergonomic one-handed fit. The recessed region flush with the first and second overmolded handle regions may be formed by an assembly portion of the first body portion 116 and the second body portion 118 that is narrower in width than the first overmolded handle region and the second overmolded grip region. In an exemplary embodiment, the recessed region may be provided between the first and second overmolded handle regions. In an exemplary embodiment, the recessed region may lack any overmolded grip surfaces.
    [0078] Figure 3 illustrates an exploded view of the exemplary automatic injection device 100 of Figures 1 and 2. In an exemplary embodiment, the first body portion 116 may include a substantially planar front surface (extending substantially along the plane LH) and left and right surfaces (which extend substantially along the LV plane). The front surface of the first body portion 116 may transition contiguously and integrally to the left and right side surfaces of the first body portion 116. The edges where the front surface transitions to the side surfaces may be sharp or smooth and rounded in order to maintain a functional device shape and for ergonomic device handling. The front and/or side surfaces of the first body portion 116 may be substantially flat or slightly convex so that the assembled housing fits ergonomically within a user's hand. The front surface may be wider on the proximal portion 106 of the device than on the distal portion 104. One of ordinary skill in the art will recognize that other exemplary shapes are possible for the first body portion 116 of the device.
    [0079] In an exemplary embodiment, the second body portion 118 may include a substantially planar front surface (extending substantially along plane L-H) and left and right side surfaces (extending substantially along plane L-V). The front surface of the second body portion 118 may contiguously and integrally transition to the left and right side surfaces of the second body portion 118. The edges where the front surface transitions to the side surfaces may be sharp or smooth and rounded in order to maintain a functional device shape and for ergonomic device handling. The front and/or side surfaces of the second body portion 118 may be substantially flat or slightly convex so that the assembled housing fits ergonomically within a user's hand. The front surface may be wider on the proximal portion 106 of the device than on the distal portion 104. One of ordinary skill in the art will recognize that other exemplary shapes are possible for the second body portion 118 of the device.
    [0080] As illustrated in Figure 3, the first body portion 116 and the second body portion 118 can be cooperatively engaged with each other along their peripheral edges to enclose and provide a cavity 102 therebetween. The second upper body portions may be cooperatively engaged with each other using any suitable technique including, but not limited to, bonding, gluing, ultrasonic welding, friction fit, snap fit, interference fit, threads, fastening between corresponding and similar protuberances and indentations. One element of common knowledge in the art will recognize that, in other exemplary embodiments, the device cavity 102 may be encased in a single body component or three or more body components when assembled together.
    [0081] An exemplary container 160 is preferably slidably positioned in cavity 102 and is coupled to an injection needle (not shown) at a distal end. The injection needle may be covered by a needle shield 162, for example a soft needle shield and/or a rigid needle shield. A container advancing mechanism may be provided within the housing to mechanically advance container 160 into and relative to the housing and to eject therapeutic agent from container 160 to perform an injection. The container advancing mechanism may include one or more actuators (e.g., one or more guide members) that move the container from a holstered position to a projecting position. When the device is in a pre-injection state, the container 160 may be in a holstered position, i.e., retracted into the housing. When the device is actuated, the container advancing mechanism can advance the container 160 to a projecting position so that the injection needle protrudes from a distal end of the housing to allow ejection of the therapeutic agent into a body of the patient. The distal end of the housing may include an opening through which the needle may protrude.
    [0082] The cavity 102 within the housing can also accommodate a trigger engagement mechanism, for example the trigger button 120. The trigger button 120, when actuated by lowering, activates the container advance mechanism which, by in turn, it advances container 160 toward the injection site, directs the injection needle to the injection site, and delivers the therapeutic agent to the injection site. In an exemplary embodiment, at least a portion of the firing button's outer surface 120 may be overmolded with one or more rubberized grip surfaces to facilitate firing button pressing by a user's finger or hand. In an exemplary embodiment, the entire outer surface of the firing button may be covered by an overmolded grip surface. In an exemplary embodiment, the grip surfaces on the firing button 120 may be colored differently from the non-grip surfaces to provide a visual appearance to indicate which area of the device is to be gripped. For example, the one or more grip surfaces on the fire button 120 may be green, while all other surfaces on the device may have one or more colors that may not be green.
    [0083] Figure 3 shows that a front surface of the first body portion 116 may include a first opening 119 through which the firing button 120 may protrude out of the front surface. An exemplary aperture 119 may be circular to accommodate the firing button 120 with a circular cross-section, although other shapes are possible. The front surface of the first body portion 116 may include a second opening 127 to accommodate the transparent inspection window 128.
    [0084] As shown in Figure 3, in an exemplary embodiment, the removable distal cap 164 may frictionally engage a recessed or protruded portion 166 of the housing in order to be retained in position in the housing when the device is not in use.
    [0085] Figure 4 illustrates a front surface of first body portion 116 of exemplary automatic injection device 100. Figure 5 illustrates a left side view of first body portion 116 and second body portion 118 as mounted on device 100 .
    [0086] As illustrated in Figure 4, an exemplary automatic injection device 100 may have a tubular and tapered shape with a substantially elongated and elliptical cross section. The proximal end end 172 of the device may have a narrower proximal end (width w1) that slightly and gradually widens to a greater width (width w2) at the distal end of the proximal end end 172. The proximal end of the first body portion 116 flush with the proximal end end 172 may include one or more recessed portions 122, 124 on the sides. The recessed portions 122, 124 can create a narrow neck portion (width w3) that is narrower than the adjacent width (width w2) of the proximal end end 172. At the distal end of the recessed portions 122, 124, the first body portion 116 can widen to the widest width of the device (width W) and can gradually taper to a narrower width (width w4) near the middle portion of the device. At the distal portion 104 of the device, the first body portion 116 may have a substantially uniform narrow width (width w4). Second body portion 118 may be substantially similar in shape and configuration to first body portion 116. As illustrated in Figure 5, in an exemplary embodiment, removable distal cap 164 may include one or more protrusions 170a, 170b (shown in Figure 5) which extend outward from the front surface and back to the surface of the distal cap 164 to further facilitate the gripping of the distal cap.
    [0087] An element of common knowledge in the art will recognize that other formats are possible in the exemplary automatic injection device 100.
    [0088] As illustrated in Figures 4 and 5, in an exemplary embodiment, a left handle surface 130 may be provided to partially cover and extend along the left side surface of the first body portion 116 and a right handle surface 132 may be provided to partially cover and extend along the right side surface of the first body portion 116. In an exemplary embodiment, each grip surface 130, 132 may be disposed between the firing button 120 and the inspection window 128. One element of common knowledge will recognize that other placements of the grip surfaces 130, 132 are possible. Similarly, in an exemplary embodiment, a left grip surface 152 may be provided to partially cover and extend along the left side surface of the second body portion 118 and a right grip surface 153 may be provided to partially cover and extends along the right side surface of the second body portion 118. When the first and second body portions are assembled, the left grip surfaces 130, 152 can form an adjoining left grip surface 154 on the housing and the right grip surfaces of handle 132, 153 may form an adjoining straight handle surface 156 on the housing. The contiguous right and left grip surfaces 154, 156 facilitate reliable and comfortable gripping and handling of the device by a user's hand, which remarkably and surprisingly improves the user experience of physically weak users, eg older users and users who suffer from rheumatoid arthritis.
    [0089] In user tests performed using exemplary automatic injection devices, test participants liked the overmolded gripping surfaces on the sides of the device, the ridges on the overmolded gripping surfaces, and the relatively large size and ergonomic shape of the device. The majority of test participants (58%) essentially preferred handling and holding an example automatic injection device of the present invention. As a whole, the device configuration example received a high average rating of 8.1 out of 10.0. Overmolded gripping surfaces were the primary factor in the high ratings of participants in the Handling and Grinding Device Example. For several utility factors, there was a significant positive correlation between Cochin scores and the example device of the present invention with the overmolded grip surfaces, which indicates that the example device of the present invention is well suited for those with manual dysfunction.
    [0090] An element of common knowledge in the art will recognize that the right and left handle surfaces may have different sizes, shapes and configurations than the exemplary sizes, shapes and configurations shown in Figures 1 to 8. An element of common knowledge in the art will recognize that more or less grip surfaces may be provided on exemplary automatic injection devices than the exemplary left and right grip surfaces shown in Figures 1 to 8. An element of common knowledge in the art will also recognize that one or more surfaces of handles may be positioned on exemplary automatic injection devices at positions other than the exemplary positions shown in Figures 1 to 8. Additionally, one of ordinary skill in the art will recognize that the outline of each handle surface may have a smooth, round, and functional in some exemplary modalities.
    [0091] The overmolded grip surfaces provided in the exemplary embodiments can be formed of any suitable material that provides a first soft feel and high friction to a user, compared to portions of the device that lack an overmolded grip surface that provides a stiff, low friction second touch perception for a user. The difference in sensory perceptions provides a touch appearance to a user, which indicates that the device should be gripped in regions provided with overmolded gripping surfaces.
    [0092] In an exemplary embodiment, overmolded gripping surfaces may be formed of a first type of material that has a soft feel and high friction to a user, while portions of the device lacking overmolded gripping surfaces may be formed from a second type of material that has a harder feel and less friction to a user. In an exemplary embodiment, overmolded grip surfaces may be formed from a first material with a lower hardness, while non-handle surfaces may be formed from a second material with a higher hardness.
    [0093] For example, handleless surfaces can be formed from any rigid thermoplastic material or rigid substrate suitable for use in a medical device application and suitable to provide a hard touch perception with low friction to the user. Rigid thermoplastics can include materials such as polypropylene (PP), polyethylene (PE), polystyrene (PS), high impact polystyrene (HIPS), polycarbonate (PC), acrinitrile-butadiene-styrene (ABS), poly(ethylene terephthalate ) (PET), polyamide (PA), PC/ABS blend and PPO/PS blends.
    [0094]Exemplary overmolded grip surfaces can be formed from materials that have any suitable grade of material and hardness to provide a high friction, soft feel to the user. Exemplary overmolded grip surface materials may include, but are not limited to, rubber (e.g., which has a 50A durometer in one embodiment), thermoplastic elastomers (TPEs), thermoplastic vulcanizate (TPV), and the like. Exemplary thermoplastic elastomers that can be used to form exemplary overmolded grip surfaces include, but are not limited to, TPEs from KRAIBURG, DynaflexTM TPE from PoliOne, VersaflexTM TPE from PoliOne, VersollanTM TPE from PoliOne, OnFlexTM TPE from Polione and the like. Exemplary thermoplastic vulcanizates that can be used to form exemplary overmolded grip surfaces include, but are not limited to, ExxonMobil's Santoprene™ thermoplastic and the like.
    [0095] In an exemplary embodiment, overmolded grip surfaces may be colored differently from non- grip surfaces to provide a visual appearance to indicate which area of the device is to be gripped. For example, the overmolded left and right gripping surfaces can be brown in color while the non-gripping surfaces on the housing can be gray in color.
    [0096] As illustrated in Figure 5, in an exemplary embodiment, one or more ridges (which protrude from the outer surface) and/or one or more grooves or holes (which are lowered into the outer surface) 158a, 158b, 158c (as illustrated in Figures 5 and 6B) may be provided on the left overmolded handle surface 154 and/or on the right overmolded handle surface 156 to further facilitate handling and handling of the device. The shapes and locations of the ridges and/or grooves can be changed as desired and any desired number of ridges and/or grooves can be provided. In an exemplary embodiment, the ridges and/or grooves may extend substantially perpendicularly to the longitudinal geometric axis L of the device. In an exemplary embodiment, the overmolded grip surfaces may include textured surfaces to enhance tactile feel and further facilitate firm gripping of the device.
    [0097] Figure 6A is a front close-up view of an exemplary overmolded left grip surface 130 provided in a first body portion 116 of device 100 of Figure 1. Figure 6B is a left side close-up view of the grip surface Exemplary overmolded left 130 of Figure 6A. The right overmolded handle surface 132 of the first body portion 116, the left overmolded handle surface 152 of the second body portion 118, and the right overmolded handle surface 153 of the second body portion 118 may be similar in structure and configuration.
    [0098] Referring to Figures 6A and 6B, the overmolded left handle surface 130 may have a first longitudinal side 134 that extends over the front surface of the first body portion 116 substantially along the longitudinal axis L. In an exemplary embodiment, the first longitudinal side 134 of the overmolded left handle surface 130 may be substantially linear, while in another exemplary embodiment, the first longitudinal side 134 may be slightly concave or convex. A proximal end 136 of the first longitudinal side 134 may extend towards and connect to an end 138 of a first horizontal side 140 of the overmolded left handle surface 130. The first horizontal side 140 may extend along the left side surface of the first body portion 116 substantially along the second transverse geometric axis V, which terminates at the peripheral edge of the first body portion 116.
    [0099] In an exemplary embodiment, a connecting side 142 extending between ends 136, 138 can connect the first longitudinal side 134 to the first horizontal side 140. In an exemplary embodiment, the first horizontal side 140 can include a beveled edge extending to the first longitudinal side 134 at an angle to both the longitudinal axis L and the first transverse geometric axis H.
    [00100] In an exemplary embodiment, the first longitudinal side 134 of the overmolded left handle surface 130 may be substantially longer than the first horizontal side 140. An exemplary ratio of the length of the first longitudinal side 134 to the length of the first horizontal side 140 may include, but is not limited to, about 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, all intermediate ratios and the like.
    [00101] A distal end 144 of the first longitudinal side 134 may extend towards and connect to an end 146 of a second horizontal side 148 of the overmolded left handle surface 130. In an exemplary embodiment, an extending connecting side 150 between the ends 144, 146 may connect the first longitudinal side 134 to the second horizontal side 148. In an exemplary embodiment, the connecting side 150 may have a longer length than the connecting side 142. In exemplary embodiments, a ratio of the length from connecting side 150 to connecting side length 142 may include, but is not limited to, 1.5:1, 1.75:1, 2:1, 2.25:1, 2.5:1, 2.75:1, 3:1, 3.25:1, 3.5:1, 3.75:1, 4:1, all intermediate ratios, and the like, but it is not limited to these exemplary ratios. The second horizontal side 148 may extend along the left side surface of the first body portion 116 substantially along the second transverse geometric axis V, which terminates at the peripheral edge of the first body portion 116.
    [00102] In an exemplary embodiment, the first longitudinal side 134 may be substantially longer than the first horizontal side 140 or the second horizontal side 148. An exemplary ratio of the length of the first longitudinal side 134 to the length of the horizontal side may include, but it is not limited to, about 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6: 1, 6,5:1, 7:1, all intermediate ratios, and the like.
    [00103] Figure 7 is a bottom view of an exemplary removable distal cap 164 showing overmolded grip surface 165. Overmolded grip surfaces 165 may be formed from any suitable material that first provides a soft touch perception and with high friction for a user, compared to portions of the device that lack an over-molded grip surface that provides a stiff, low friction feel for a user. The difference in sensory perceptions provides a touch appearance to a user, which indicates that the device should be gripped in the regions provided with the overmolded gripping surfaces.
    [00104] In an exemplary embodiment, overmolded grip surfaces may be formed of a first type of material that has a soft feel and high friction, while non-grip surfaces are formed of a second type of material that has a harder touch perception and with lower friction. Exemplary overmolded grip surfaces 165 can be formed from materials that have any suitable grade of material and hardness to provide a high friction, soft feel to the user. Exemplary overmolded grip surface materials may include, but are not limited to, rubber (e.g., which has a 50A durometer in one embodiment), thermoplastic elastomers (TPEs), thermoplastic vulcanizate (TPV), and the like. Exemplary thermoplastic elastomers that can be used to form the exemplary overmolded grip surfaces include, but are not limited to, TPEs from KRAIBURG, DynaflexTM TPE from PoliOne, VersaflexTM TPE from PoliOne, VersollanTM TPE from PoliOne, OnFlexTM TPE from PoliOne Polione, and the like. Exemplary thermoplastic vulcanizates that can be used to form exemplary overmolded grip surfaces include, but are not limited to, ExxonMobil's Santoprene™ thermoplastic and the like. In an exemplary embodiment, the overmolded grip surfaces 165 may be colored differently from the non-grip surfaces to provide a visual appearance to indicate which area of the device is to be gripped. For example, the one or more overmolded grip surfaces 165 on the distal cap 164 may be brown in color while the non-handle surfaces on the housing may be gray in color.
    [00105] Figure 8 is a top view of an exemplary proximal end end 172 for covering the proximal end of the housing. In an exemplary embodiment, the outer surface of the proximal end end 172 may lack any overmolded handle surfaces. In other exemplary embodiments, at least part of the outer surface of the proximal end end 172 may be overmolded with one or more grip surfaces 173 to facilitate gripping the proximal portion of the device. In an exemplary embodiment, the entire outer surface of the proximal end end 172 may be covered by an overmolded handle surface 173.
    [00106] The overmolded grip surfaces 173 can be formed of any suitable material that provides a first soft feel and high friction feel to a user, compared to portions of the device that lack an overmolded grip surface that provides a second Soft, low-friction touch perception for a user. The difference in sensory perceptions provides a touch appearance to a user, which indicates that the device should be gripped in the regions provided with the overmolded gripping surfaces.
    [00107] In an exemplary embodiment, the overmolded grip surfaces 173 may be formed of a first type of material that has a soft feel and high friction, while the non-grip surfaces are formed of a second type of material that has a harder touch perception and with lower friction. Exemplary overmolded grip surfaces 173 can be formed from materials that have any suitable grade of material and hardness to provide a high friction, soft feel to the user. Exemplary overmolded grip surface materials may include, but are not limited to, rubber (e.g., which has a 50A durometer in one embodiment), thermoplastic elastomers (TPEs), thermoplastic vulcanizate (TPV), and the like. Exemplary thermoplastic elastomers that can be used to form the exemplary overmolded grip surfaces include, but are not limited to, TPEs from KRAIBURG, DynaflexTM TPE from PoliOne, VersaflexTM TPE from PoliOne, VersollanTM TPE from PoliOne, OnFlexTM TPE from PoliOne Polione and the like. Exemplary thermoplastic vulcanizates that can be used to form the exemplary overmolded grip surfaces include, but are not limited to, ExxonMobil's Santoprene™ thermoplastic and the like. In an exemplary embodiment, the overmolded grip surfaces 173 may be colored differently from the non-grip surfaces to provide a visual appearance to indicate which area of the device is to be gripped. For example, the one or more overmolded handle surfaces 173 at the proximal end end 172 may be brown in color while the non-handle surfaces on the housing may be gray in color.
    [00108] In an exemplary embodiment, one or more ridges (which protrude from the outer surface) and/or one or more grooves or holes (which are lowered into the outer surface) may be provided on the outer surface of the proximal end end 172 to further facilitate gripping of the proximal portion of the device. The shapes and locations of the ridges and/or grooves can be changed as desired and any desired number of ridges and/or grooves can be provided. In an exemplary embodiment, the overmolded grip surfaces 173 may include textured surfaces to enhance tactile feel and further facilitate firm gripping of the device. In an exemplary embodiment, a wrapped around groove 174 may be provided around the circumference of the proximal end end 172 and a concave or recessed surface 176 may be provided on top of the proximal end end 172 to guide and guide a hand and fingers. from the user to the device. For example, the concave or recessed surface 176 can accommodate a finger on the surface 176 while the user is performing an injection using the device.
    [00109] In some exemplary embodiments, housing 101, removable distal cap 164 and/or proximal end end 172 of device 100 may additionally include graphics, symbols and/or numbers to facilitate use of the automatic injection device. For example, the distal cap 164 may include a disclosure of an arrow on an outer surface that points to the distal end of the device to indicate how the device is to be held relative to the patient (ie, with the distal end adjacent to the location of the device. injection). An element of common knowledge in the art will recognize that the automatic injection device may have any suitable graphics, symbols and/or numbers to facilitate patient instruction or the automatic injection device may omit such graphics, symbols and/or numbers.
    [00110] Figure 9 is a flowchart of an exemplary method of assembling an exemplary automatic injection device. In an exemplary embodiment, a housing of an exemplary automatic injection device may be provided in two or more separate housing components (e.g., first and second body portion) that may be coupled during assembly of the device.
    [00111]In step 902, a first housing body portion is provided or formed. In step 904, one or more grip surfaces are overmolded into corresponding recesses in the outer surface of the first body portion to facilitate gripping and manipulation of the device during an injection.
    [00112]In step 906, a second housing body portion is provided or formed. In step 908, one or more grip surfaces are overmolded into corresponding recesses in the outer surface of the second body portion to facilitate gripping and manipulation of the device during an injection.
    [00113] In step 910, a proximal end end of the housing is provided or formed. In step 912, one or more grip surfaces are overmolded into corresponding recesses in the outer surface of the proximal end end to facilitate gripping and manipulation of the device.
    [00114] In step 914, a removable distal housing cap is provided or formed. In step 916, one or more handle surfaces are overmolded into corresponding recesses in the outer surface of the distal cap to facilitate removal of the distal cap prior to performing an injection.
    [00115]In step 918, a housing firing button is provided or formed. In step 920, one or more grip surfaces are overmolded on the outer surface of the fire button to facilitate activation of the fire button to perform an injection.
    [00116]In step 922, one or more internal components of the automatic injection device can be positioned in a defined cavity between the second upper body portions. Exemplary device components may include, but are not limited to, a container (eg, a syringe) pre-filled with a therapeutic agent for injecting into a patient, an injection needle attached to a distal end of the container, a mechanism a container advance for advancing the container in and relative to the housing towards the injection site and for ejecting the therapeutic agent from the container during an injection, a trigger button for activating the container advance mechanism and the like.
    [00117] In step 924, the second upper body portions can be cooperatively engaged to form a body assembly that surrounds and retains the internal components within the cavity. In an exemplary embodiment, the body portions may be coupled at their peripheral edges. Any suitable coupling or joining can be used in step 924 which includes, but is not limited to, bonding, gluing, ultrasonic welding, friction fit, press fit, interference fit, threads, mating protrusions and recesses, and the like.
    [00118]In step 926, the removable distal cap can be removably attached to a distal end of the body assembly to cover an injection needle or a needle shield which, in turn, covers the injection needle.
    [00119]In step 928, the proximal end end may be coupled to a proximal end of the body assembly.
    [00120] Any suitable fabrication technique may be used to form any of the device components that includes, but is not limited to, injection molding. Device components can be formed from any suitable material including, but not limited to, plastics, thermoplastics, polycarbonates, metals and the like.
    [00121] It is noted that the order of steps discussed in the present invention can be changed as desired and that other manufacturing steps/techniques are possible and are considered within the spirit and scope of the present invention. Automatic Injection Device User Tests
    [00122] Forty-four test subjects were recruited to test both the exemplary automatic injection devices that have overmolded grip surfaces of the present invention and four alternative automatic injection devices without such grip surfaces. A majority of participants were suffering from rheumatoid arthritis (RA) at the time of testing. Participants were diagnosed with RA from 1 to 40 years of age, with a mean age at diagnosis of 9 years of age. Four participants were suffering from Crohn's disease at the time of testing. Test Procedure
    [00123]Each test participant tested the different exemplary auto injection device configurations. In particular, in an example device use phase, each trial participant performed a sham injection (ie, an injection with perforated needles and no medication) using the devices. After performing a sham injection, each test participant was asked a series of follow-up questions designed to assess the participant's approval of the form and function of the devices. These questions included questions about, for example, size, shape, ease of handling, grip comfort, overall user experience and the like. Device Handling and Handling
    [00124]By performing simulated injections using the different device configurations, test participants were asked to provide feedback and comparative ratings on handling and grip, overall ease of use, and comfort in performing the injection steps. All device settings were rated on a scale of 1 (very negative) to 10 (very positive).
    [00125] The majority of test participants (58%) essentially preferred the handling and gripping of the device configuration example of the present invention, compared to four alternative device configurations that did not include overmolded gripping surfaces. Test participants particularly liked the rubberized overmolded handles on the side of the device example and its relatively large size, which made the device example easy and comfortable to hold. The rubberized overmolded grips were the primary factor in high ratings of participants in the example handle and grip device configuration as taught in the present invention.
    [00126] Additionally, a correlation analysis was performed on manual dysfunction using the Cochin Manual Deficiency Scale with ratings provided for certain utility factors: handling and grip, ease of use, ease of starting and performing an injection , injection execution comfort, acceptability and general preference. For several utility factors, there was a significant positive correlation between the Cochin scores and the device configuration example of the present invention, which indicates that this device configuration example is well suited for those with manual dysfunction. Handle Comfort and Device Usage
    [00127]By performing simulated injections in the device usage phase example, test participants were asked to rate the comfort of holding the device configuration example of the present invention and four alternative device configurations that did not include any surfaces overmolded handles. Test participants rated each device configuration on a scale of 1 (very low confidence) to 7 (very high confidence). The majority of test participants favored the device configuration example of the present invention for comfort in performing injection steps, with a 45% rating being the highest. Ease of Use and Device Handling
    [00128] Upon initial exposure to the example device and before receiving instructions or a demonstration of its use, test participants were asked about the perceived ease of use of the example device configuration of the present invention and four alternative device configurations which did not include any overmolded gripping surfaces. Test participants rated each device configuration on a scale of 1 (very difficult) to 7 (very easy). All device configurations received high ratings for their perceived ease of use.
    [00129]By performing simulated injections in the actual device use phase, test participants were asked to rate the ease of handling of each device configuration. Test participants rated each device configuration on a scale of 1 (very low confidence) to 7 (very high confidence). Additionally, by performing simulated injections using device configuration in the third phase of real device use, test participants were also asked to rate the configurations on their overall ease of use on a scale of 1 (very difficult) to 10 (very easy).
    [00130] The majority of test participants (42%) found the example device configuration of the present invention easier to use compared to four alternative device configurations that did not include overmolded gripping surfaces. Overall, the device configuration example of the present invention received a high average rating of 7.97 out of 10.0. Device Size
    [00131]By performing simulated injections in the device usage phase example, test participants were asked to rate the overall size of the device configuration example of the present invention and four alternative device configurations that did not include any surfaces of takes overmolded on a scale of 1 (very low confidence) to 7 (very high confidence). All device configurations have generally received positive ratings for their overall format. In general, test participants struggled to form larger preferred devices tightened on the wrist. The device configuration example of the present invention generally received the highest ratings. Device Format
    [00132]By performing simulated injections in the actual device use phase, test participants were asked to rate the general format of the device configuration example of the present invention and four alternative device configurations that did not include any grip surfaces overmolded on a scale of 1 (very low confidence) to 7 (very high confidence).
    [00133]All device configurations generally received positive ratings for their overall size. In general, test participants struggled to form larger preferred devices tightened on the wrist. Regarding the device configuration example of the present invention, many participants found that the shape fits ideally in their hand. III. Incorporation into a Reference Title
    [00134] The contents of all references, which include patents and patent applications, cited throughout this application are hereby incorporated into the present invention by way of reference in their entirety. Appropriate components and methods from these references can be selected for the invention and embodiments thereof. Furthermore, the components and methods identified in the Background section are integral to this disclosure and may be used in conjunction with or substituted for components and methods described elsewhere in the disclosure within the scope of the invention. IV. Equivalents
    [00135]In the description of exemplary modalities, specific terminology is used for the sake of clarity. For descriptive purposes, each specific term is intended to at least include all technical and functional equivalents that operate in a similar manner to accomplish a similar purpose. Additionally, in some cases where a particular exemplary embodiment includes a plurality of system elements or method steps, those elements or steps may be replaced by a single element or step. Likewise, a single element or step can be replaced by a plurality of elements or steps that serve the same purpose. Additionally, where parameters for various properties are specified in the present invention for exemplary embodiments, these parameters can be adjusted up or down by 1/20-, 1/10-, 1/5-, 1/3-, 1/ 2a, and the like, or by rounding approximations thereto, unless otherwise specified. Furthermore, although exemplary embodiments have been shown and described with references to particular embodiments thereof, elements of common knowledge in the art will understand that various substitutions and changes in form and detail can be made therein without departing from the scope of the invention. . Additionally, other aspects, functions and advantages are also included within the scope of the invention.
    [00136]Exemplary flowcharts are provided in the present invention for illustrative purposes and are non-limiting examples of methods. An element of common knowledge in the art will recognize that the exemplary methods may include more or fewer steps than those illustrated in the exemplary flowcharts and that the steps in the exemplary flowcharts may be performed in a different order than shown.
    权利要求:
    Claims (16)
    [0001]
    1. Automatic injection device, CHARACTERIZED in that it comprises: a housing (101) enclosing a cavity (102) to accommodate a container (160), the housing having a proximal portion (106) adapted to be held by a hand of a user and a distal portion (104) adapted to perform an injection, the proximal portion (106) having a front face and an opposite rear face that are planar, and the first and second side faces are convex; a first overmolded handle surface (130) extending longitudinally along a portion of the housing on the first side face of the housing; a second overmolded handle surface (132) extending longitudinally along a portion of the housing (101) on the second side face of the housing opposite the first side face, and a trigger button (120) located on the front face or rear face. of the proximal portion (106).
    [0002]
    2. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the first and second overmolded grip surfaces (130, 132) in the housing (101) include one or more grooves or ridges (158).
    [0003]
    3. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the first and second overmolded grip surfaces (130, 132) in the housing (101) are formed from a first material having a first perception and the handleless surfaces in the housing are formed from a second material that has a second sense of touch.
    [0004]
    4. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the first and second overmolded grip surfaces (130, 132) in the housing (101) are formed from a first material having a first hardness and the handleless surfaces on the housing are formed from a second material which has a second higher hardness.
    [0005]
    5. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the first and second overmolded grip surfaces (130, 132) in the housing (101) have a different color from the non-handle surfaces in the housing.
    [0006]
    6. Automatic injection device according to claim 1, CHARACTERIZED in that it further comprises: a removable distal cap (164) for protectively covering an injection needle attachable to the container (160), an outer surface of the distal cap which includes an overmolded grip surface (165).
    [0007]
    7. Automatic injection device according to claim 6, CHARACTERIZED by the fact that the outer surface of the distal cap includes one or more grooves and/or ridges (165).
    [0008]
    8. Automatic injection device, according to claim 1, CHARACTERIZED by the fact that the trigger button (120) is positioned along a transverse geometric axis perpendicular to a longitudinal axis of the device.
    [0009]
    9. Automatic injection device according to claim 8, CHARACTERIZED by the fact that it further comprises: a recessed surface (126) provided adjacent to the firing button (120).
    [0010]
    10. Automatic injection device according to claim 9, CHARACTERIZED by the fact that the recessed surface (126) is provided surrounding the firing button (120).
    [0011]
    11. Automatic injection device according to claim 1, CHARACTERIZED in that it further comprises: a proximal end end (172) for covering a proximal end of the automatic injection device, wherein the proximal end end has an outer surface overmolded (173).
    [0012]
    12. Automatic injection device according to claim 11, CHARACTERIZED by the fact that a top surface of the proximal end end includes a recessed surface (176).
    [0013]
    13. Automatic injection device, according to claim 1, CHARACTERIZED by the fact that it further comprises: a transparent inspection window (128) arranged in the housing (101).
    [0014]
    14. Automatic injection device, according to claim 13, CHARACTERIZED by the fact that, at the end of an injection, the inspection window (128) is filled with a visual indicator.
    [0015]
    15. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the first and second overmolded grip surfaces (130, 132) are disposed on the proximal portion (106) of the device and extend through portions of the first and second side faces.
    [0016]
    16. Automatic injection device according to claim 1, CHARACTERIZED by the fact that the housing comprises a plurality of housing components cooperatively engaged to define the cavity (102) therein.
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    AU2016200762B2|2018-04-05|
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    法律状态:
    2018-12-18| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2020-08-18| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2021-01-12| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2021-06-08| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-07-13| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/01/2012, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201161435465P| true| 2011-01-24|2011-01-24|
    US61/435.465|2011-01-24|
    US61/435,465|2011-01-24|
    PCT/US2012/022433|WO2012103141A1|2011-01-24|2012-01-24|Automatic injection devices having overmolded gripping surfaces|
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