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  • 专利说明
  • 权利要求
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    • 专利摘要:
    SYSTEM AND METHOD FOR DETERMINING A BREATHING PARAMETER OF AN INDIVIDUAL RECEIVING THERAPY. A system is configured to determine one or more breathing parameters for an individual, such as one or both of end-expiratory carbon dioxide concentration, and/or respiratory rate. The system is configured to establish a plurality of preliminary determinations of an individual breath parameter in accordance with a plurality of different algorithms. A final respiration parameter determination is obtained by selecting one of the preliminary determinations based on therapy parameters, gas parameters, and/or other parameters that impact the accuracy and/or precision of different algorithms.
    公开号:BR112013014798B1
    申请号:R112013014798-9
    申请日:2011-12-09
    公开日:2021-08-03
    发明作者:Michael Brian Jaffe；Joseph Allen Orr
    申请人:Koninklijke Philips N.V.；
    IPC主号:
    专利说明:

    DESCRIPTION FIELD
    The invention relates to the determination of end-expiratory carbon dioxide concentration and/or respiratory rate. DESCRIPTION OF RELATED TECHNIQUE
    Systems configured to determine an individual's breathing parameters such as end-tidal carbon dioxide concentration and respiratory rate are known. Typically these systems implement a single algorithm to determine a given respiration parameter based on the output signals of a gas sensor in communication with gas in or near the individual's airway. These algorithms generally provide an increase in precision and/or accuracy under some conditions, while producing somewhat marginal results under other conditions. As a result, the use of conventional systems for determining respiration parameters can produce results having accuracy and/or precision that is not consistent for a variety of conditions. SUMMARY
    One aspect of this description pertains to a -=-25 system configured to determine a breathing parameter for an individual receiving therapy. In one embodiment, the system comprises one or more sensors and one or more processors. The one or more sensors are configured to generate output signals that transmit information relating to one or more gas parameters of the gas in or near the individual's airway. The one! or more processors are configured to run modules that include a therapy parameter module, a breath parameter module, and a select module. The therapy parameter module is configured to determine one or more 5 therapy parameters that are provided to the individual. The breath parameter module is configured to determine a breath parameter of the subject's breath, and includes a first breath parameter sub-module and a second. breathing parameter sub-module. The first breath parameter sub-module is configured to establish a first breath parameter determination based on output signals according to a first algorithm. The second respiration parameter sub-module is configured to establish a second respiration parameter determination 15 based on the output signals according to a second algorithm, where the impact of one or more therapy parameters on accuracy and/or precision of the first algorithm differs from the impact of one or more therapy parameters on the accuracy and/or precision of the second algorithm. The selection module is configured to select either the first breath parameter determination or the second breath parameter determination as a final breath parameter determination based on one or more therapy parameters being provided to the subject. One aspect of this disclosure relates to a method of determining a breathing parameter of an individual receiving therapy. In one embodiment, the method comprises generating output signals that transmit information relating to one or more gas parameters of the gas in or near the subject's airway 30; determine one or more therapy parameters that are provided to the individual; preparing a first determination of a respiration parameter based on the output signals according to a first algorithm; establish a second respiration parameter determination based on the 5 output signals according to a second algorithm that is different from the first algorithm, wherein the impact of one or more therapy parameters on the accuracy and/or precision of the first algorithm is different from the impact of one or more therapy parameters on the accuracy and/or precision of the second algorithm; and 10 selecting the first respiration parameter determination or the second respiration parameter determination as a final respiration parameter determination based on one or more therapy parameters that are provided to the subject.
    Yet another aspect of the description relates to a system for determining a breathing parameter of an individual receiving therapy. In one embodiment, the system comprises means for generating output signals that transmit information relating to one or more gas parameters of the gas in or near the individual's airway; means for determining the one or more therapy parameters that are provided to the individual; means for establishing a first determination of a respiration parameter based on the output signals in accordance with a first algorithm; means for establishing a second respiration parameter determination based on the output signals according to a second algorithm that is different from the first algorithm, wherein the impact of one or more therapy parameters on accuracy and/or precision from the first algorithm is different from the impact of one or more therapy parameters on the accuracy and/or precision of the second algorithm; and means for selecting the first respiration parameter determination or the second respiration parameter determination as a final respiration parameter determination based on one or more therapy parameters that are provided to the subject.
    These and other objects, aspects, and features of the present description, as well as the methods of operation and functions of the related structural elements and the combination of parts and manufacturing economies, will become more apparent in consideration of the following description and the appended claims 10 with reference to the accompanying drawings all of which form a part of this specification, in which like reference numerals indicate corresponding parts in various figures. In one embodiment, the structural components illustrated here are drawn to scale. It is to be expressly understood, however, that the drawings are for illustrative and descriptive purposes only and are not a limitation. Furthermore, it should be appreciated that the structural features shown or described in any of the embodiments herein can be used in other embodiments as well.
    It is to be expressly understood, however, that the drawings are for illustrative and descriptive purposes only and are not intended as a definition of boundaries. As used in the specification and claims, the singular form of "a", "an", and "the", "a" includes plural referents unless the context clearly dictates otherwise. BRIEF DESCRIPTION OF THE DRAWINGS
    FIG. 1 illustrates a system configured to determine one or more breathing parameters of an individual. FIG. 2 illustrates a method of determining an individual's breathing parameter. DETAILED DESCRIPTION OF EXEMPLARY ACHIEVEMENTS
    FIG. 1 illustrates a system 10 configured to determine one or more respiration parameters for an individual 12. In some examples described below, one or more respiration parameters 5 include one or both of the end-expiratory carbon dioxide concentration and/or the frequency, respiratory. It will be appreciated that these examples are not intended to be limiting and the scope of this description includes • other breathing parameters. In particular, system 10 is configured to establish a plurality of preliminary determinations of an individual breath parameter in accordance with a plurality of different algorithms. A final respiration parameter determination is obtained by selecting one of the preliminary determinations based on therapy parameters, gas parameters, and/or other parameters that impact the accuracy and/or precision of different algorithms. In one embodiment, system 10 includes an electronic storage 14, a user interface 16, a detector system 18, a processor 20, and/or other components.
    In one embodiment, an electronic storage 14 comprises an electronic storage medium that electronically stores information. Electronic storage means of electronic storage 14 may include one or both of a system storage that is provided integrally (i.e., substantially non-removable) to a system 10 and/or a removable storage that is removably connected. to a system 10 via, for example, a port (eg a USB port, a firewire port, etc.) or a drive (eg a disk drive, etc.). An electronic storage 14 may include one or more of an optically readable storage medium (e.g., optical disks, etc.), a magnetically readable storage medium (e.g., magnetic tape, magnetic hard disk, floppy drive, etc.) , a storage medium based on electrical charge (eg, EEPROM, RAM, etc.), a solid-state storage medium (eg, pen drive, etc.), , and/or other electronically readable storage medium. An electronic storage 14 can store software algorithms, information determined by processor 20, information received through a user interface 16 and/or other information that allows a system 10 to function correctly. Electronic storage 14 can be a separate component within system 10, or electronic storage 14 can be provided integrally to one or more other 15 components of system 10 (e.g., a processor 20).
    User interface 16 is configured to provide an interface between a system 10 and a user (eg the user, a caregiver, a therapist etc.) whereby the user can provide information to and receive information from the system 10. enables data, results, and/or instructions and any other items that communicate, collectively referred to as "information," to be communicated between the user and the system 10. Examples of interface devices * 25 suitable for inclusion in user interface 16 include a numeric keypad, keys, switches, a keyboard, buttons, levers, a display screen, a touch screen, speakers, a microphone, an indicator light, an audible alarm and a printer.
    It is to be understood that other communication techniques, either wired or wireless, are also contemplated by the present invention as user interface 16. For example, in one embodiment, a user interface 16 may be integrated with a storage interface 5 removable storage provided by electronic storage 14. In this example, the information can be loaded into the removable storage system 10 (eg a smart card, a pen drive, a removable disk etc.) which - allows the user(s) customize system implementation10. Other exemplary input devices and techniques adapted for use with a system 10 as user interface 16 include, but are not limited to, an RS-232 port, an RF connection, an IR connection, a modem (telephone, cable or otherwise) . In short, any technique for communicating information with the system 10 is contemplated as user interface 16.
    Detector system 18 is configured to obtain gas from or near the individual's airway 12, and to generate output signals that transmit information obtained from measurements performed by the obtained gas. Detector system 18 is configured 20 to receive gas obtained in or near the individual's airway 12 through an inlet 22. The gas is transmitted to inlet 22 through an individual interface tool 24 and/or a conductor 26. The subject interface tool 24 may couple one or more airway holes '25 of the subject 12 in a sealed or unsealed manner. Some examples of subject interface tool 24 may include, for example, an endotracheal tube, a nasal cannula, a tracheostomy tube, a nasal mask, a nasal/oral mask, a face mask, a full face mask, a partial rebreathing mask, or other interface tools that communicate a gas flow with an individual's airway. The present invention is not limited to these examples, and contemplates the implementation of the individual interface.
    Conductor 26 is configured to place input 22 of detector system 18 in fluid communication with subject 24 interface tool 4 such that gas obtained by subject interface tool 24 in or near subject 12 airways is supplied to input 22 through a conductor 26. In one embodiment, the detector system 18 is configured for lateral flow sampling. In this configuration, a conductor 26 is further configured to place the subject interface tool 24 in fluid communication with a source of a respirable substance. For example, a flow of breathable gas can be administered to an individual 12 through conductor 26 who has one or more parameters that are controlled in accordance with a regimen of therapy. The one or more breathable gas flow parameters that are controlled may include one or more of pressure, flow, composition, humidity, temperature, and/or other parameters. In one embodiment, a detector system 18 is configured for main stream sampling. In this configuration, a detector system 18 is disposed within the flow path through conductor 26, rather than being disposed off to the side (as shown in '25 FIG. 1). In one embodiment where detector system 18 is configured for lateral flow sampling, or where conduit 26 does not provide a supply of a breathable substance to the individual 12's airways, a pump (not shown) is configured to withdraw gas from the conductor 26 within 30 of detector system 18 through input 22.
    Detector system 18 includes one or more sensors 28. Sensors 28 are configured to generate output signals that transmit information relating to one or more gas parameters of the gas within detector system 18. The one or more gas parameters may include one or more plus concentrations of gaseous molecular species (eg carbon dioxide, oxygen and/or other molecular species), a flow, a pressure, a temperature, a humidity and/or other gas parameters. It will be appreciated that the illustration of sensors 28 in FIG. 110 as an individual component within detector system 18 is not intended to be limiting. In one embodiment, sensors 28 can be a single sensor, or can include a plurality of sensors.
    Processor 20 is configured to provide 15 information processing capabilities in system 10. Like, processor 20 may include one or more of a digital processor, an analog processor, a digital circuit designated to process information, an analog circuit designated to processing information, a machine state and/or other mechanisms for electronically processing information.
    Although processor 20 is shown in FIG. 1 as a single entity, this is for illustrative purposes only. In some implementations, processor 20 may include a plurality of processing units. These processing units may be physically located within the same device, or the processor 20 may represent processing functionality of a plurality of devices operating in coordination.
    As shown in FIG. 1, a processor 20 may be configured to execute one or more computer program modules. The one or more computer program modules may include one or more of a gas parameter module 32, a respiration rate module 34, a carbon dioxide at the end of expiration module 36, an interface module 38, a therapy parameter module 40, a selection module 42 and/or other modules. Processor 20 can be configured to run modules 32, 34, 36, 38, 40 and/or 42 through software; hardware; firmware; some combinations of * software, hardware, and/or firmware; and/or other mechanisms for configuring processing capabilities in processor 20.
    It will be appreciated that although modules 32, 34, 36, 38, 40 and/or 42 are illustrated in FIG. 1 as being colocated within a single processing unit, in implementations where processor 20 includes multiple processing units, one or more modules 32, 34, 36, 38, 40 and/or 42 may be remotely located in the other modules. The description of the functionality provided by the different modules 32, 34, 36, 38, 40 and/or 42 described below is for illustrative purposes, and is not intended to be limiting, like any modules 32, 34, 36, 38, 40 and/or 42 may provide more or less functionality than are described. For example, one or more modules 32, 34, 36, 38, 40 and/or 42 can be eliminated, and some or all of these functionality can be provided to other modules 32, 34, 36, 38, 40 and/or s 25 42. As another example, a processor 20 may be configured to run one or more additional modules that may establish some or all of the functionality assigned below to one of modules 32, 34, 36, 38, 40 and/or 42.
    Gas parameter module 32 is configured to determine one or more gas parameters of gas in or near the individual's airways 12 based on output signals generated by sensors 28. The one or more gas parameters may include a or more concentrations of gaseous molecular species (eg carbon dioxide, oxygen and/or other 5 molecular species), a flow, a pressure, a temperature, a humidity and/or other gas parameters.
    The respiratory rate module 34 is configured to determine a respiratory rate of the individual 12. The respiratory rate module 34 includes a first respiratory rate submodule 44, a second respiratory rate submodule 46, an nth respiratory rate submodule 48, and /or other submodules. The individual sub-modules 44, 46 and 48 are configured to determine the respiratory rate of the individual 12 based on the output signals generated by the sensors 28 and/or the gas parameters determined by the gas parameter module 32. Each of the individual sub-modules 44, 46 and 48 is configured to determine the respiration rate according to an algorithm different from other sub-modules 44, 46 and 48.
    Each of the different algorithms is impacted differently with respect to the accuracy and/or precision of various conditions. For example, under a first set of conditions, the respiration rate determination by the second respiration rate submodule 46 may be more accurate and/or accurate than the respiration rate determination by the nth respiration rate submodule 48. But under one In the second set of conditions, the determination of respiration rate by the nth respiration rate submodule 48 may be accurate and/or accurate than the determination of respiration rate 30 by the second respiration rate submodule 46.
    Differences in conditions can be described by, for example, therapy parameters related to the therapy being administered to the individual 12. Therapy parameters can include one or more current therapeutic procedures, a current therapy device, a context in which the therapy is being delivered, an individual parameter and/or other parameters of the therapy. Parameters describing a current therapeutic procedure may describe, for example, - invasive ventilation, non-invasive ventilation, cardiopulmonary resuscitation, sedation and/or other procedures. Parameters that describe a context in which therapy is being delivered may describe, for example, the state of emergency, the clinical situation (eg, intensive care, progress of operation, emergency vehicle) and/or other contextual parameters. Subject parameters may describe one or more aspects of subject 12 (e.g. age, weight, height, blood pressure, pulse rate, preexisting conditions and/or other aspects).
    End-expiration carbon dioxide module 36 is configured to determine the end-expiration carbon dioxide concentration of the subject 12. End-expiration carbon dioxide module 36 includes a first end-expiratory carbon dioxide sub-module. of exhalation 50, a second end-expiration carbon dioxide submodule '25 52, an nth end-expiration carbon dioxide submodule 54, and/or other submodules. The individual sub-modules 50, 52 and 54 are configured to determine the carbon dioxide concentration at the end of exhalation of the individual 12 based on the output signals generated by the sensors 28 and/or by the 30 gas parameters determined by the gas parameter module 32. Each of the individual submodules 50, 52, and 54 is configured to determine the end-tidal carbon dioxide concentration according to a different algorithm than the other submodules 50, 52, and 54. Each of the different algorithms is impacted differently with respect to accuracy and/or accuracy for various conditions. Conditions can be described by therapy parameters such as those described above.
    The interface module 38 is configured to receive input from a user (eg, a caregiver, a therapist, a researcher, an individual 12 and/or other users) related to one or more parameters of the therapy. In one embodiment, the interface module 38 is configured to receive a definition of a therapy parameter. For example, an interface module 38 can be configured to receive a definition of a current therapeutic procedure, a current therapy device, a context in which therapy is being delivered, an individual parameter, and/or other therapy parameters. User input can be received by module 20 of interface 38 via a user interface 16.
    Therapy parameter module 40 is configured to determine one or more therapy parameters automatically. For example, a system 10 may include one or more sensors (not shown) configured to generate output signals that indicate information relating to one or more current therapeutic procedures, a current therapy device, a context in which the therapy is being distributed, an individual parameter, and/or other therapy parameters. Therapy parameter module 40 is configured to automatically determine 30 settings for one or more therapy parameters from these output signals. The therapy parameters may include the gas parameters of the pressurized flow of the breathing gas taken by sensors other than sensor 28. For example, a pressure sensor and/or a flow sensor included in detector 518 and/or associated with a generator (not shown, for example, a fan) can generate output signals that convey information related to gas parameters of the pressurized breathable gas flow that are not implemented by > any sub-modules 44, 46, 48, 50, 52 and/or 54. These gas parameters can provide information regarding the therapy and/or the individual even if they are not implemented in the respiration parameter determination.
    Selection module 42 is configured to select among sub-modules of a given breath parameter module 15 based on one or more therapy parameters defined through user input and/or through automatic determination by therapy parameter module 40 The selection module 42 may select among sub-modules to increase the accuracy and/or precision of a final determination of respiration parameter 20 under actual conditions defined by one or more therapy parameters. The selection may include selecting a set of submodules to establish preliminary respiration parameter determinations and/or selecting a final respiration parameter determination from a set of preliminary determinations.
    For example, with respect to respiratory rate module 34, a selection module 42 may be configured to select a set of submodules 44, 46 and/or 48 to establish preliminary respiratory rate determinations. The determination of which submodules 44, 46 and/or 48 should make preliminary determinations of respiratory rate can be made based on therapy parameters such that the set of submodules 44, 46 and 48 that make preliminary determinations are the submodules that implement the 5 algorithms that tend to increase accuracy and/or precision under conditions defined by current therapy parameters. It will be . It is appreciated that the selection of a set of sub-modules 44, 46 and/or 48 to establish preliminary determinations of respiratory rate is not intended to be limiting. In one embodiment, all sub-modules 44, 46 and 48 are implemented to make preliminary determinations.
    The selection module 42 can be configured to select a final breath rate determination from preliminary breath rate determinations. The selection module 42 can perform this selection based on one or more therapy parameters and/or its own preliminary determinations. Selection can be based on analyzes of preliminary determinations to identify artifacts commonly indicative of inaccuracy and/or imprecision. The identification of 20 such artifacts in the preliminary respiratory rate determination by the selection module 42 can be facilitated by looking at artifacts sometimes or commonly presented in the respiratory rate determination by a given respiratory rate algorithm used to z 25 establish the preliminary determination a be analyzed. The identification of such artifacts can be further enhanced or improved by looking for one or more artifacts commonly presented under present conditions (as described by the therapy parameters). Another dependence on therapy parameters and/or preliminary determinations is/are contemplated.
    In one embodiment, selection module 42 is configured to determine a reliability metric indicating the reliability of one or more preliminary determinations. Such as a metric determined for a preliminary determination may reflect signal stability, a rate of change, a trend, a noise level, « an adequacy of the data for the patient's size (if 10 patient is neonatal or pediatric, the expected measurement must be different from that expected for an adult patient) and/or other aspects of the preliminary determination that indicate whether the preliminary determination is accurate and/or accurate. For example, if the preliminary determination is determined to fluctuate over time, this may indicate a noise present in the preliminary determination that reduces the reliability of the determination. The reliability metric for the preliminary noise determination should reflect this noise...
    The selection module 42 can further be configured on the basis of the preliminary determination selection in the analysis of the therapy parameters together with the determined reliability metric(s) for the individual preliminary determinations. Sensitive to the determined reliability metric(s) for a given preliminary determination ' 25 indicating relatively low reliability (eg due to noise and/or other phenomena), the given preliminary determination cannot be determined as a final determination. Similarly, sensitive to the determined reliability metric(s) for a given preliminary determination indicating a relatively high reliability, the given preliminary determination may be given priority to other preliminary determinations with a low reliability.
    With respect to end-expiration carbon dioxide module 36, selection module 42 can be configured to select a set of sub-modules 50, 52 and 54 to establish preliminary determinations of end-expiratory carbon dioxide concentration, and /or to select the final determination of the end-tidal carbon dioxide concentration from the preliminary determinations of the end-tidal carbon dioxide concentration made by sub-modules 50, 52 and/or 54. The selection of sub-module set 50, 52 and/or 52 to establish preliminary determinations, and/or selection of a final determination of end-expiratory carbon dioxide concentration can be made based on one or more therapy parameters and/or reliability metrics to enhance the accuracy and/or precision of the determination of the end-tidal carbon dioxide concentration under the present conditions. The selection may be performed similarly to or as the same as described 20 above with respect to the selection(s) of the respiratory rate determinations made by a selection module 42.
    FIG. 2 illustrates a method 56 of determining an individual's breathing parameter. The operations of method 56 shown below are intended to be illustrative. In some embodiments, method 56 can be performed with one or more additional operations not described, and/or without one or more operations discussed. Additionally, the order of operations of method 56 is illustrated in FIG. 2 and described below is not intended to be limiting.
    In some embodiments, method 56 may be implemented in one or more processing devices (e.g., a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state of the machine and/or other mechanisms for electronically processing information) . The one or more processing devices may include one or more devices that perform some or all of the operations of method 56 in response to instructions stored electronically in the electronic storage medium. The one or more processing devices may include one or more devices configured through hardware, firmware and/or software to be specifically designed to perform one or more operations of method 56.
    In an operation 58, output signals that transmit information relating to one or more gas parameters of the gas in or near an individual's airway are generated. The one or more gas parameters may include one or more concentrations of gaseous molecular species (eg carbon dioxide, oxygen and/or other molecular species), a flow, a pressure, a temperature, a humidity and/or others gas parameters. In one embodiment, operation 58 is performed by one or more sensors that are the same as, or similar to, sensors 28 (shown in FIG. 1 and described below).
    In an operation 60, one or more gas parameters of the gas in or near the individual's airways are determined based on the output signals generated in an operation 58. In one embodiment, operation 60 is performed by a gas parameter module that is the same as, or similar to, a gas parameter module 32 (shown in FIG. 1 and described above).
    In an operation 62, input related to one or more therapy parameters can be received from a user. In one embodiment, operation 62 is performed by an interface module that is the same as, or similar to, an interface module 38 (shown in FIG. 1 and described above).
    In an operation 64, one or more parameters of the therapy are determined. The one or more therapy parameters may include one or more current therapeutic procedures, a current therapy device, a context in which therapy is being delivered, an individual parameter, and/or other therapy parameters. Determine one or more therapy parameters described in the current conditions under which the breath parameter is being determined. The one or more therapy parameters can be determined based on a user input received in an operation 62, of the output signals of sensors that transmit information related to the therapy parameter(s) and/or determined based on in other information. In one embodiment, operation 64 is performed by a therapy parameter module that is the same as, or similar to, a therapy parameter module 40 (shown in FIG. 1 and described above).
    In an operation 66, a set of submodules is selected to establish preliminary respiration parameter determinations. The sub-modules each implement a separate algorithm for determining the respiration parameter as a function of the output signals generated in an operation 58 and/or the gas parameters determined in an operation 60. The accuracy and/or precision of different algorithms in determining the respiration parameter are differently impacted by the therapy parameters. Selecting the set of submodules in one run 66 from a larger group of submodules selects the submodules by implementing algorithms that typically have increased accuracy and/or precision under the conditions described by the therapy parameters determined in one run 68. In one embodiment, operation 66 is performed by a selection module which is the same as, or similar to, a selection module 42 (shown in FIG. 1 and described above). Selection of the set of submodules may include selecting between a group of submodules that is the same as, or similar to, a group of submodules 44, 46, and 48 (shown in FIG. 1 and described above), and/or that is the same as, or similar to, the group of submodules 50, 52, and 54 (shown in FIG. 1 and described above).
    In an operation 68, preliminary respiration parameter determinations are made based on the output signals 15 generated in an operation 58 and/or gas parameters determined in an operation 60. The preliminary determinations are made by the set of submodules selected in an operation 66.
    In an operation 70, the final breath parameter determination 20 is selected from the preliminary breath parameter determinations made in an operation 68. The selection of the final breath parameter determination is made based on the therapy parameters determined in an operation 64 , preliminary determinations of the breath parameter itself, 25 of the gas parameters determined in an operation 60, and/or based on other information. Selection of the final respiration parameter determination is made to select the preliminary respiration parameter determination that typically has increased accuracy and/or precision under current conditions. Operation 70 may include determining one or more reliability metrics for one of the individual from the preliminary determinations. The determined reliability metric(s) for a given preliminary determination may indicate the reliability of the given preliminary determination. The reliability metric(s) may reflect a rate of change, a trend, a noise level and/or other aspects of the preliminary determination that indicate whether a given preliminary determination is accurate and/or accurate. The selection of the final determination in an operation 70 may further be based on the determined reliability metric(s) in conjunction with other considerations listed above. In one embodiment, operation 70 is performed by selection module which is the same as, or similar to, selection module 42 (shown in FIG. 1 and described above).
    The details included here are for the purpose of illustration based on what is currently considered to be the most practical and preferred achievements, it is to be understood that such details are for the purpose only and that the scope of this descriptive report is not limited to the 20 achievements described , but rather is intended to cover modifications and equivalent provisions that are within the spirit and scope of the appended claims. For example, it is to be understood that the present description contemplates that, as far as possible, one or more aspects of any embodiment 25 may be combined with one or more aspects of any other embodiment.
    权利要求:
    Claims (10)
    [0001]
    1. SYSTEM CONFIGURED TO DETERMINE A BREATHING PARAMETER OF AN INDIVIDUAL RECEIVING THERAPY, the system comprising: one or more sensors (28) configured to generate output signals that transmit information related to one or more gas parameters in or near the pathways the individual's airways; and one or more processors (20) configured to execute modules, the modules comprising: a therapy parameter module (40) configured to determine one or more therapy parameters being provided to the subject; a respiration parameter module (34, 36) configured to determine a respiration parameter of the subject's respiration, the respiration parameter module comprising: a first respiration parameter sub-module (44, 50) configured to establish a first preliminary respiration parameter determination based on the output signals of according to a first algorithm; and a second breath parameter sub-module (46, 52) configured to establish a second preliminary breath parameter determination based on output signals according to a second algorithm, wherein an impact of one or more therapy parameters on accuracy and /or on the accuracy of the first algorithm the impact is different from the impact of one or more therapy parameters on the accuracy and/or precision of the second algorithm; and a selection module (42) configured to select the first preliminary respiration parameter determination or the second respiration parameter determination as a final respiration parameter determination; characterized by the selection module (42) being configured to base said selection in an analysis of the first and second preliminary determinations to identify artifacts indicative of inaccuracy and/or imprecision in the determination of a respective respiration parameter by the first and second algorithms of the respective first and second preliminary determinations, in which the artifacts comprise commonly present artifacts under conditions described by one or more therapy parameters to be provided to the individual.
    [0002]
    2. SYSTEM according to claim 1, characterized in that the selection module is further configured to determine a reliability metric for at least one of the first and second preliminary determinations of the respiration parameter that indicates a reliability, and in which the The selection module is further configured to select between the first and second preliminary determinations based on the determined reliability metric.
    [0003]
    3. SYSTEM according to claim 1, characterized in that one or more parameters of the therapy comprise one or more therapeutic procedures, a device for delivering current therapy, a context in which the therapy is being delivered, or a parameter of the individual.
    [0004]
    4. SYSTEM according to claim 1, characterized in that the respiration parameter is a concentration of carbon dioxide at the end of expiration.
    [0005]
    5. SYSTEM according to claim 1, characterized in that the respiration parameter is a respiration rate.
    [0006]
    6. METHOD OF DETERMINING A BREATHING PARAMETER OF AN INDIVIDUAL RECEIVING THERAPY, the method comprising: generating (58) output signals that transmit information relating to one or more gas parameters of the gas in or near the individual's airways; and determining (64) one or more therapy parameters being preliminary provided to the subject; establishing (68) a first preliminary determination of a respiration parameter based on output signals in accordance with a first algorithm; establishing (68) a second preliminary determination of the respiration parameter based on output signals according to a second algorithm that is different from the first algorithm, where the impact of one or more therapy parameters on the accuracy and/or precision of the first algorithm is different from the impact of a or more therapy parameters on the accuracy and/or precision of the second algorithm; selecting (70) the first preliminary respiration parameter determination or the second preliminary respiration parameter determination as a final respiration parameter determination characterized by said selection (70) being based on the analyzes of the first and second preliminary determinations to identify artifacts indicative of inaccuracy and/or imprecision in the determination of a respiration parameter by the first and second algorithms of the respective first and second preliminary determinations, in which artifacts comprise artifacts commonly present under conditions described by one or more therapy parameters to be provided to the individual.
    [0007]
    7. METHOD, according to claim 6, characterized in that it further comprises the determination of a reliability metric for at least one of the first and second preliminary determinations of the respiration parameter that indicates a reliability, and in which the selection between the first and second preliminary determinations are still based on the determined reliability metric.
    [0008]
    8. METHOD according to claim 6, characterized in that one or more therapy parameters comprise one or more of a current therapeutic procedure, a current therapy delivery device, a context in which the therapy is being delivered, or a parameter of the individual.
    [0009]
    9. METHOD, according to claim 6, characterized in that the breathing parameter is a concentration of carbon dioxide at the end of expiration.
    [0010]
    10. METHOD, according to claim 6, characterized in that the breathing parameter is a respiratory rate.
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    法律状态:
    2018-12-04| B25D| Requested change of name of applicant approved|Owner name: KONINKLIJKE PHILIPS N.V. (NL) |
    2018-12-18| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2018-12-26| B25H| Request for change of headquarter rejected|Owner name: KONINKLIJKE PHILIPS N.V. (NL) Free format text: INDEFERIDO O PEDIDO DE ALTERACAO DE SEDE CONTIDO NA PETICAO 860160010584 DE 12/01/2016, EM VIRTUDE DO DEPOSITANTE DO PEDIDO JA ESTAR COM O ENDERECO SOLICITADO. |
    2019-12-24| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-05-25| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-03| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/12/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201061424152P| true| 2010-12-17|2010-12-17|
    US61/424,152|2010-12-17|
    PCT/IB2011/055569|WO2012080920A1|2010-12-17|2011-12-09|System and method for determining one or more breathing parameters of a subject|
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