• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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  • 优先权
    • 专利摘要:
    inhaler the present invention relates to an inhaler comprising a housing that defines a chamber for receiving a strip having a plurality of ampoules each containing a dose of medicine for inhalation by a user. it comprises an actuation lever and an actuation member of the ampoule strip pivotally mounted in the chamber to sequentially move each ampoule to an ampoule opening position. the actuating member of the ampoule strip and the actuating lever comprise an actuating gear element, respectively, which cooperates to effect the rotation of the actuating member of the ampoule strip in response to the rotation of the actuating lever. the drive gear and the drive gear element are arranged outside the housing away from the chamber.
    公开号:BR112013013026B1
    申请号:R112013013026-1
    申请日:2011-11-25
    公开日:2021-03-23
    发明作者:Andreas Meliniotis；Stephen Eason；Roger Clarke；Liam McGuinness
    申请人:Vectura Delivery Devices Limited；
    IPC主号:
    专利说明:

    [0001] [0001] The present invention relates to an inhalation device for oral or nasal delivery of medicament in the form of powder. More specifically, the invention relates to an inhaler that has a housing for receiving a strip having a plurality of ampoules spaced along the length of the strip, each ampoule having a perforable cap and containing a dose of the medicine for inhalation by a user. The invention also relates to an inhaler containing a strip of ampoules each having a perforable cap and containing a dose of the medicine for inhalation by a user of the device according to the invention.
    [0002] [0002] The oral or nasal delivery of a drug using an inhalation device is a particularly attractive method of drug administration since these devices are relatively easy for a patient to use discreetly and in public. Like the release medication to treat local airway diseases and other respiratory problems, they are more recently used to release drugs into the bloodstream through the lungs, thereby avoiding the need for hypodermic injections.
    [0003] [0003] It is common for dry powder formulations to be prepacked in individual doses, usually in the form of capsules or ampoules, each containing a single dose of powder that has been precisely and consistently measured. An ampoule is generally formed from a laminate of ductile metal foil or a plastic material and includes a perforable cap that is permanently heat sealed around the periphery of the ampoule during manufacture and after the dose is introduced into the ampoule. A foil ampoule is preferred over capsules since each dose is protected against the ingress of water and the penetration of gases such as oxygen, in addition to being shielded against light and UV radiation, all having a detrimental effect on the release characteristics of the inhaler if a dose becomes exposed to them. Therefore, an ampoule offers excellent environmental protection with each individual drug dose.
    [0004] [0004] Inhalation devices receiving a package of ampoules comprising a number of ampoules, each of which contains a pre-measured and individually packaged dose of the drug to be delivered, are known. The actuation of the device causes a mechanism to break or break an ampoule, such as perforating it or detaching the cap, so that when the patient inhales, air is extracted through the ampoule, introducing the dose into it, which is then carried out from the ampoule through the device and through the patient's airway to the lungs. Pressurized air or gas or other propellants can also be used to drive the dose out of the vial. Alternatively, the mechanism that punctures or opens the ampoule can push or eject the dose out of the ampoule into a receptacle from which the dose can subsequently be inhaled.
    [0005] [0005] It is advantageous for the inhaler to be able to retain a number of doses to enable it to be used repeatedly over a period of time without the requirement to open and / or insert an ampoule into the device each time it is used. Therefore, many conventional devices include means for storing a number of ampoules, each containing an individual dose of medication. When a dose is to be inhaled, an indexing mechanism moves a previously emptied ampoule out through the opening mechanism so that a new one is moved into a position ready to be used open for inhaling its contents.
    [0006] [0006] An inhaler of the type described above is known from the Applicant's copending international application which was published as WO2005 / 037353 A1.
    [0007] [0007] In accordance with an embodiment described and claimed in WO 2005/037353 A1, and illustrated in Figures 1 and 2 of the accompanying drawings, an inhaler 1 has a housing 2 containing a spiral strip of ampoules 3. An indexing mechanism 4 comprising a single actuating lever 5 unwinds the spiral 3 an ampoule at once so that they pass over an ampoule locating chassis 6 and successively through an ampoule drilling station 7, when the actuator 5 is pivoted in a direction indicated by arrow "A" in Figure 2. The ampoule 3a located in the ampoule drilling station 7 in each movement of the actuator 5 is drilled in the return stroke of the actuator 5 in the direction indicated by the arrow "B" in Figure 2) by the drilling elements 8 over the actuator 8 itself so that, when a user inhales through a nozzle 9, an air flow is generated inside the ampoule 3a to introduce a dose contained therein and lead it out of the ampoule 3a through the nozzle 9 and pa inside the user's airway.
    [0008] [0008] The known device of WO2005 / 037353 A1 has already been modified to provide a fully integrated device, that is, one in which the used ampoules are retained within their housing so that a user never has to come into direct contact with the strip of ampoules. In a modified embodiment, known from the Applicant's previous application for ownership which is now published as WO09 / 007352 A1, a flexible and resilient spiral element is provided mounted within the device housing into which the used portion of the ampoule strip is provided. directed so that, as the strip is gradually consumed, the spiral expands as more and more of the strip is fed or pushed into it between its spirals. The inhaler of the present invention, in its preferred form, is also a fully integrated device that holds used ampoules, although in a preferred embodiment it has a wall to separate the interior of the housing within used and unused ampoule compartments. The wall is preferably rigid and slidably mounted so that the size of the used and unused ampoule compartments changes with respect to each other as the number of ampoules being used increases and the number of unused ampoules decreases.
    [0009] [0009] The document mentioned above also describes an embodiment in which the used ampoules are crushed between the indexing and driving wheel of the ampoule strip and the inner surface of the device wrap, which is also a feature of the inhaler of the present invention. As the crushing occurs as the used strip passes around the drive member of the ampoule strip, a curled or curved shape is transmitted to the strip which helps it to spiral within the chamber.
    [0010] [00010] The inhaler of the invention may also incorporate a mechanism for triggering the ampoule strip or the indexing mechanism that forms the objective of the Applicant's previous international application for property which is now published as WO2009 / 092652 A1.
    [0011] [00011] The descriptions of WO2005 / 037353 A1, WO09 / 007352 A1 and WO2009 / 092652 A1 are all incorporated herein by reference.
    [0012] [00012] The present invention seeks to provide another inhalation device of the type described in the applications mentioned above, which also has a relatively simple construction, is robust, simple to manufacture and easy for the patient to use.
    [0013] [00013] In accordance with the invention, an inhaler is provided comprising a housing defining a chamber for receiving a strip having a plurality of ampoules each containing a dose of medicine for inhalation by a user, an actuating lever and an actuating member of the ampoule strip rotatably mounted in the chamber to sequentially move each ampoule to an ampoule opening position, wherein the ampoule strip drive member and the actuation lever comprise a drive gear and a drive gear element, respectively , which cooperate to effect the rotation of the drive member of the ampoule strip in response to the rotation of the actuation lever, said drive gear and drive gear element being arranged outside the housing away from the chamber. This has the advantage that the drive gear and the drive gear element are isolated from any residual dust that can be deposited inside the chamber.
    [0014] [00014] The inhaler may comprise a mouthpiece through which a dose of medicine can be inhaled and a cover pivotally mounted on the housing to cover the mouthpiece. The drive gear and the drive gear element are preferably arranged between the housing and the cover so as to be enclosed by said cover. As the cover covers the drive gear and the drive gear member, they are protected from ingress of dirt and are out of sight and cannot be contacted by a person handling the device.
    [0015] [00015] In a preferred embodiment, the housing has opposite side wall surfaces and the cover has portions that extend through the respective side wall surfaces, said drive gear and drive gear element being arranged between one of said surfaces. side wall and one of said cover portions.
    [0016] [00016] In one embodiment, the drive gear of the drive member of the ampoule strip includes a shaft that extends through an opening in a side wall surface of the housing, for coupling to the drive wheel of the ampoule strip.
    [0017] [00017] Preferably, the actuation lever comprises an actuation button that extends through the exterior of the housing between said opposite side wall surfaces of the housing, and a plate-like portion extending from each end of the actuation button through the respective side wall surfaces outside the housing, under said portions of cover. In this embodiment, the drive gear element on the actuation lever is preferably formed on one of said plate-like portions. As the actuation lever is pivotally supported at two points, spaced from each other by the width of the housing, the support for the lever is improved as opposed to them being mounted at only one point and is more resistant to being twisted around of a geometric axis extending radially from its pivot axis.
    [0018] [00018] Each portion similar to the actuation lever plate can be pivotally mounted to a respective side wall surface of the housing to pivotally mount the actuation lever to the outside of the housing away from the chamber.
    [0019] [00019] In a preferred embodiment, the inhaler comprises a piercing member that pivots in response to the rotation of the actuation lever to pierce the lid of an aligned ampoule, wherein one of the actuation lever and the ampoule piercing member have a actuation cam element and the other actuation lever and the ampoule piercing member have a actuation cam surface, the actuation cam element and the actuation cam surface cooperating with each other in response to the rotation of the lever actuating so that the ampoule piercing element pivots to pierce the lid of an aligned ampoule.
    [0020] [00020] In a preferred embodiment in which the drilling member pivots together with the nozzle, the nozzle being pivotally mounted to the housing so that the nozzle pivots to pierce the lid of an ampoule aligned in response to the rotation of the actuation lever. In this mode, the nozzle can be pivotally mounted to the outside of the housing away from the chamber.
    [0021] [00021] Preferably, the nozzle has peripheral walls extending from the opposite edges that extend through the respective side wall surfaces outside the housing away from the chamber, said peripheral walls being pivotally mounted to said side wall surfaces of the housing . At least one of the driving cam element and housing cam surface can be formed on one of said peripheral walls.
    [0022] [00022] Preferably, the drive cam element and the drive cam surface are arranged under a cover portion.
    [0023] [00023] The modalities of the invention will now be described, by way of example only, with reference to Figures 3 to 16 of the accompanying drawings, in which: FIGURES 1 and 2 are side views of a conventional inhalation device to show how a strip is actuated to sequentially move ampoules in alignment with an ampoule piercing element by moving an actuator from the position shown in Figure 1 to the position shown in Figure 2 that drives an indexing wheel. A drill head on the actuator pierces the lid of an aligned ampoule when the actuator is returned to its normal position, as shown in Figure 1, FIGURES 3a to 3e are a sequence of drawings to show the general function and operation of the inhaler according to the invention; FIGURE 4 is a side elevation of an inhalation device according to an embodiment of the invention; FIGURE 5 is the side elevation of Figure 4, but with the cover removed so that the internal components can be seen; FIGURE 6 is the side elevation of Figure 5 after removing one half of the wrapper forming the inhaler housing; FIGURE 7 is an exploded perspective view showing the components of the inhaler according to the invention; FIGURE 8 is a partial perspective view of the indexing mechanism of the vial strip for use in the inhaler of the invention; FIGURE 9 is a partial perspective view of the indexing mechanism of the vial strip shown in Figure 8 after the partial rotation of the actuation lever to an intermediate position from its normal position; FIGURE 10 is the same view shown in Figure 9, but without the optional cantilever chassis arm; FIGURE 11 is a partial perspective view of the indexing mechanism of the ampoule strip shown in Figures 8 to 10, after the actuation lever is rotated to a point where the actuation between the actuation coupling and the actuator is disengaged; FIGURE 12 is a partial perspective view of the opposite side of the indexing mechanism shown in Figures 9 to 11; FIGURE 13a is a perspective view of the drive coupling used in the indexing mechanism of the inhaler shown in Figures 9 to 12; FIGURE 13b is a side view of the drive coupling illustrated in Figure 13a in which the flexible flange portion has been deflected in a "T" direction towards the axis or towards the indexing wheel mounted on that axis; FIGURE 14 is a partial view of the inhaler according to the invention showing the shape and position of the indexing wheel that can be used in order to crush the used ampoules as they pass around the indexing wheel; FIGURE 15 is an exploded perspective view showing the individual components of the inhaler according to another embodiment of the invention; FIGURE 16 is a cross-sectional side view of the inhaler shown in Figure 15; and FIGURES 17a to 17f illustrate another modified embodiment of the inhaler according to the invention, which incorporates a plug to block the mouthpiece.
    [0024] [00024] Referring now to Figures 3a to 3e of the accompanying drawings, an inhaler 10 is shown having a housing 11 formed from two wrap portions 11a, 11b (see Figures 6 and 7), a cover 12 pivotally mounted to the housing 11 for rotation about a geometric axis marked "C" (see Figures 5 to 7) from a closed position as shown in Figure 4 where the cover 12 covers and protects a nozzle 13 to a fully open position, as shown in Figures 3 (b) to 3d) and in a direction indicated by the arrow "R" in Figure 3 (a), where the mouthpiece 13 is exposed to enable a user to inhale a dose of the medicine through the mouthpiece 13.
    [0025] [00025] It should be noted that the cover is "passive" in the sense that it can be opened and closed freely without performing an indexing function of the ampoule strip or causing an ampoule piercing member 13 depending on the nozzle 13 to pierce the lid of an ampoule aligned.
    [0026] [00026] The cover 12 is rotated to its fully open position in the direction of the arrow "R". An actuation lever 14 is revealed as soon as the cover 12 is rotated out of its closed position. The user then applies pressure to the actuation lever 14, so that it rotates in the direction indicated by the arrow "S" in Figure 3 (b).
    [0027] [00027] During the initial rotation of the actuation lever 14 through a first portion of its stroke to the position as shown in Figure 3 (b), the strip is indexed in order to move an unused ampoule in alignment with the limb ampoule perforation 15.
    [0028] [00028] When the acting member is rotated through a second portion of its course beyond the position shown in Figure 3 (b) and after having completed the first portion of its course, in the direction of the arrow "T" in Figure 3 (c), the strip remains stationary, but the nozzle 13 is now pivoted so that the ampoule piercing member 15 pierces the cap of the previously aligned ampoule.
    [0029] [00029] Although reference is made to an ampoule piercing member 15, it will be appreciated that multiple openings are formed in the cap of the ampoule so that air can be drawn into the ampoule through one or more of these openings and flow outward of the ampoule together with a dose of medicine introduced, through one or more other openings and through the mouthpiece into the patient's airway.
    [0030] [00030] Once the actuation lever is in the position shown in Figure 3 (c), the user now inhales through the mouthpiece 13, as shown by the arrows indicated by "U" in Figure 3 (d).
    [0031] [00031] After inhalation, the user rotates the cover in the opposite direction, that is, in the direction indicated by "V" in Figure 3 (c). During this movement, the cover 12 engages with the actuation lever 14 so that the actuation lever 14 also returns to its initial position as shown in Figure 3 (a), the strip remaining stationary during this actuation return movement 14.
    [0032] [00032] As mentioned above, cover 12 is passive, although it does not perform the function of resetting the actuating member back to its original position if the actuating lever is compressed before closing the cover.
    [0033] [00033] As mentioned earlier, the inhaler of the invention has an indexing mechanism that has been described previously with reference to WO2009 / 092652 A1. This aspect of the invention inhaler will now be described in detail with reference to Figures 8 to 13a. Although the drawings show a slightly different arrangement, in which an actuator 54 takes the place of the drive gear 16 attached to the drive coupling member 57 in the present invention, the principle remains the same since the actuator 54 and the drive gear they are both rotated to index the strip. Therefore, the rotation of the drive gear 16 performs the same function as the rotation of the actuator 54 referred to in the description of Figures 8 to 13a below.
    [0034] [00034] Referring now to Figure 8, a partial perspective view of an inhalation device 50 comprising an indexing mechanism 51 is shown.
    [0035] [00035] The indexing mechanism 51 includes an indexing wheel 53 comprising four vanes 55a, 55b, 55c, 55d, each having an enlarged head portion 56a, 56b, 56c, 56d. As is clear from the references in Figures 1 and 2, once a strip of ampoules (not shown in Figures 8 to 14) passes over the ampoule locating chassis 53, it passes around the indexing wheel 55. An ampoule is located in the space between two vanes 55a, 55b, 55c, 55d so that, as the indexing wheel 55 rotates in response to the rotation of the actuator 54, a vane 55a, 55b, 55c, 55d engages an ampoule located between the vanes 55a, 55b, 55c, 55d so as to drive the strip around the indexing wheel 55 to sequentially move each ampoule forward a sufficient distance to move a new ampoule into alignment with an ampoule piercing element.
    [0036] [00036] The indexing mechanism 51 includes a drive coupling member 57 (more clearly shown in Figures 13a and 13b) to selectively or temporarily couple the actuator 54 to the indexing wheel 55 so that, when coupled, the indexing wheel 55 rotates in response to the rotation of actuator 54 to index the strip. The drive coupling member 57 comprises an axis 58 defining an axis of rotation "A" (see Figures 13a and 13b) in which the indexing wheel 55 is received rotatably so that it can rotate freely around the axis 58 around of said axis of rotation "A". The actuator 54 is fixedly attached to the drive coupling member 57 (the gear drive can also be fixedly attached to the drive coupling member 57) so that the drive coupling member 57 rotates along with the actuator 54 on all moments. In the embodiment illustrated and described with reference to Figures 8 to 12, the actuator 54, the drive coupling member 57 and the indexing wheel 55 are all coaxially mounted for rotation about the same geometric axis "A". However, it will be appreciated that in the embodiment of Figure 7, the nozzle 13 and the actuation lever 14 are not mounted coaxially with the geometric axis "A".
    [0037] [00037] The drive coupling member 57 has a circular flange 59 that extends radially from one end of the shaft 58. A portion 60 of the flange is cut (see arched opening 61 in Figure 13a) at an angle of approximately 180 degrees where flange 59 joins shaft 58 so that this portion 60 of flange 59 is not directly attached to shaft 58, but only to the remaining portion of flange 59 at each of its ends 60a, 60b. As a result, this portion 60 of the flange 59 is flexible with respect to the rest of the flange 59 and can be deflected out of the plane of the flange 59 that extends at right angles to the geometric axis of the axis, in an axial direction (indicated by "T" and "S", in Figure 13b) either towards or away from axis 58 or, more importantly, towards or away from the indexing wheel 55 that is mounted on axis 58, when force is applied to it . This flexible flange portion 60 hinges about the geometric axis B which intersects the geometric axis A of the axis 58 and the actuator 54, but extends at right angles thereto. The drive coupling member 57, or at least the flange 59, is made of a resilient material so that when the deflected flexible flange portion 60 is released, it returns to its neutral unstressed position, in which it is coplanarized with the remaining fixed portion of flange 59.
    [0038] [00038] The flexible flange portion 60 has a flange deflection clamp 62 formed integrally projecting radially from its circumferential edge. The flange deflection clamp 62 has first and second faces in angled engagement 63, 64 on opposite sides. When the drive coupling member 57 is rotated in response to the rotation of the actuator 54 in one direction, one of the first or second angled engagement faces 63, 64 cooperates with a fixed formation 65 in the housing 52 to cause the flange portion flexible 60 deviates in a first direction. When the driving coupling member 57 is rotated in the opposite direction, the other angled engaging face cooperates with the formation 65 in the housing 52 to cause the flexible flange portion 60 to deviate in a second opposite direction as will be explained in more detail below.
    [0039] [00039] The flexible flange portion 60 also has an indexing wheel drive clamp 66 in arcuate shape, which remains straight in an axial direction from its surface towards the indexing wheel 55 in the same direction as axis 58 and extends partially around the circumference of the flexible flange portion 60. As will now be explained in more detail below, and the end face 66a (see Figure 13a) of the indexing wheel drive clamp 66 engages a reed 55a, 55b, 55c, 55d of the indexing wheel 55 when the flexible flange portion 60 has been deflected in a first direction, as indicated by the "T" arrow in Figure 13b (the flange portion 60 is shown in its offset position in Figure 13b) , so that the indexing wheel 55 is driven together with the drive coupling member 57.
    [0040] [00040] As mentioned above, the flange deflection clamp 62 engages a formation 65 on the housing 52 when the drive coupling member rotates in response to the rotation of the actuator 54 so as to flex the deflectable portion 60 of the flange 59. This formation 65 comprises first and second tracks or tracks 67, 68 in an arcuate shape positioned one above the other in the axial direction. The surface of the innermost track 67 is visible in Figure 8. The lower or outermost track 68 is located below it and is visible in Figure 12. The ends of the tracks 67a have angled faces for reasons that will become evident.
    [0041] [00041] When the actuator 54 (or the drive gear) is rotated in a first direction, the drive coupling member 57 rotates with it and the first angled surface facing outward 63 over the flange deflection clamp 62 contacts the angled face 67a of the innermost track 67. Another rotation of the drive coupling member 57 causes the flange deflection clamp 62 to rise over the surface of the innermost track 67 thereby deviating the flexible flange portion 60 inwardly, that is, in a direction within the housing 52 or towards the axis 58 and the indexing wheel 55.
    [0042] [00042] When the flexible flange portion 60 has been shifted inward in the direction of arrow T, another rotation of the drive coupling member 57 causes the drive clamp of the indexing wheel 66 to engage a reed, which, as shown in Figure 8 is the reed 55c of the indexing wheel 55 so that the indexing wheel 55 rotates together with the drive coupling member 57 and the drive to the indexing wheel 55 is engaged.
    [0043] [00043] When the end of the innermost track 67 is reached, the flange deflection clamp 62 falls off the surface of the track 67 and the resilience of the flexible flange portion 60 causes it to return to its unstressed or neutral position. When the drive coupling member 57 is still rotated, the drive clamp of the indexing wheel 66 no longer engages with the reed 55c of the indexing wheel 55 and instead passes under it so that the indexing wheel 55 remains stationary. Therefore, the drive of the indexing wheel 55 is disengaged in spite of the continued rotation of the actuator 54 in the same direction.
    [0044] [00044] When the actuator 54 is rotated back in the opposite direction to its normal position, the second angled surface facing inward 64 of the flange deflection clamp 62 now counted the lower or outermost track 68 so that the deflection clamp flange 62 now rises on the surface of this second track 68, thereby causing the flexible flange portion 60 to deviate outwardly or in the opposite direction to the direction in which it was previously deflected. The engagement of the flange deflection clamp 62 with the outermost track 68 in order to deflect the flange portion 60 in the opposite direction allows the driving coupling member 57 to rotate in the opposite direction without any drive for the indexing wheel 55. It will be It is appreciated that if the flange portion 60 has not been deflected in the opposite direction, the flange deflection clamp 62 can simply engage against the end of formation 65 in housing 52 when rotated back in the opposite direction, thereby preventing rotation in the opposite direction. opposite, or, the flange deflection clamp 62 can travel back over the innermost track 67 by deflecting the flexible flange portion 60 in the same direction causing the opposite end 66b of the indexing wheel drive clamp 66 to engage with a reed 65b of the indexing wheel 65 thereby driving the indexing wheel 65 backwards instead of leaving it stationary with no drive engaged. Therefore, it is necessary to ensure that the flexible flange portion 60 is deflected in the opposite direction so that there is no drive for the indexing wheel during the rotation of the coupling member 67 in the opposite direction.
    [0045] [00045] When the flange deflection clamp 62 reaches the end of the outermost track 68, the flexible flange portion 60 returns to its original unstressed or neutral position, due to its resilience.
    [0046] [00046] It will be appreciated that the extent of rotation of the indexing wheel 55 with respect to the extent of rotation of the actuator 54 can be controlled by changing the circumferential length of the internal and external tracks 67, 68. If the tracks become longer, the flexible flange portion 60 will be shifted to a larger portion of the angle through which the actuator 54 is rotated and thus the drive clamp of the indexing wheel 66 will be engaged with the indexing wheel 55 to rotate the indexing wheel 55 by this whole angle. If required, tracks 67, 68 can be made long enough so that the indexing wheel 55 rotates during the rotation of the actuator 54 through its entire angle of movement in one direction. Alternatively, tracks 67, 68 can be made shorter to reduce the angle through which actuator 54 and indexing wheel 55 stick together. Ideally, the length of the tracks can be selected so that the indexing wheel 55 is rotated through an angle sufficient to move the next unused ampoule in alignment with the ampoule perforation element.
    [0047] [00047] The other rotation of the actuator 54 (the gear drive) causes the nozzle to rotate so that the ampoule piercing member pierces the cap of an ampoule that has been exactly moved in alignment with the ampoule piercing element.
    [0048] [00048] It will be appreciated that the indexing mechanism 51 is designed to allow a stroke to be aborted when the actuator 54 or the cover has been rotated through an angle which is sufficient to cause the initial indexing of the strip, but which is not such that the drive for the indexing wheel 55 has disengaged, that is, the position in which the flange deflection clamp 62 does not reach the end of the innermost track 67. If the stroke is aborted and the actuator 54 is returned to its original position before once the drive to the index wheel 55 has disengaged (or the drive gear rotated back to its initial position), the strip will be driven back to its original position as a rear surface 66b of the drive clamp of the index wheel 66 will engage a preceding reed 55b for driving the indexing wheel 55 in the opposite direction.
    [0049] [00049] The indexing mechanism 51 also includes optional means to lock the indexing wheel 55 to prevent its rotation between the indexing steps and the means to temporarily release that locking, to allow the rotation of the indexing wheel 55 when activated by the clamp drive of the indexing wheel 66. Locking also improves the positional accuracy of the strip and, more specifically, the next ampoule to be punctured. This locking arrangement will now be described in more detail below, although it can be noted that the locking mechanism can be omitted entirely.
    [0050] [00050] The ampoule locating chassis 53 can optionally comprise a flexible cantilever arm 70 that extends from the chassis body 53 towards the indexing wheel 55. The free end of the cantilever arm 70 has a portion head 71 comprising a slot, window or opening 72 in the form of a collecting box, in which the head 56c of a reed 55c of the indexing wheel 55 is located. Opening 72 is dimensioned so that the reed head 56c of the reed 55c (as shown in Figure 8) is a comfortable fit in it so that rotation of the indexing wheel 55 is prevented. In the normal or local position of the actuator 54, the head 56c is located in said opening 72 in the cantilever arm 70 of the chassis 53 so that rotation of the indexing wheel 55 is prevented.
    [0051] [00051] When the actuator 54 is rotated and the flange deflection clamp 62 engages the innermost track 67 in order to deflect the flexible portion of the flange 60 inwardly towards the indexing wheel 55, the driving clamp of the flange wheel indexing 66 initially engages with a protrusion 71a extending from an inner side of the increased head 71 on the cantilever arm 70 of the chassis 53 so that the cantilever arm 70 is deflected outwards, away from the indexing wheel 55, to free the head 56c from the reed 55c from the slot 72, thereby unlocking the indexing wheel 55. Only once has the indexing wheel 55 been released by the drive clamp of the indexing wheel 66 by pushing the cantilever arm 70 to away from the indexing wheel 55 the drive clamp of the indexing wheel 66 subsequently engages a reed 55c of the indexing wheel 55 so that another rotation of the drive coupling member 57 rotates the indexing wheel 55.
    [0052] [00052] Before the flange deflection clamp 62 falls off the end of the innermost track 67 and the flexible flange portion 60 returns to its non-deflected state for its resilience, the indexing wheel drive clamp 66 no longer pushes against the cantilever arm 70 and thus the cantilever arm 70 is free to move back towards the indexing wheel 55. Since the cantilever arm 70 is free to move back just before the rotation of the indexing wheel 55 that is completed, the cantilever arm is prevented from moving all the way back through the head 56b of a next reed 55b which contacts the cantilever arm 70. During another rotation of the indexing wheel, the head 56b slides through the arm in cantilever and then falls into opening 72 thereby leaving the cantilever arm 70 to move all the way back and lock the indexing wheel 55 in position before any further rotation of the drive coupling member 5 7 in response to the continued rotation of the actuator 54.
    [0053] [00053] In the return stroke of actuator 54, it will be appreciated that the deviation of the flexible flange portion 60 in the opposite direction, that is, in a direction away from the indexing wheel, also ensures that the drive clamp of the indexing wheel 66 remove the chassis arm 70 and thus the indexing wheel 55 is no longer unlocked, thereby preventing any rotation of the indexing wheel 55 during the return stroke.
    [0054] [00054] The drive member of the ampoule strip or indexing wheel of the invention may take a slightly different shape from that described with reference to Figures 8 to 13b, although the principle still remains the same. In particular, the indexing wheel 17 can be used to squeeze out the used ampoule cavities as they pass around it, thereby at least partially crushing them. This is achieved by enlarging the geometry axis or hub 18 of the indexing wheel so that the distance (X in Figure 14) between the hub and the wrap or wall of the device 11 or a component attached to the wrap 11 is less than the height maximum of one ampoule cavity. As the cavities of the ampoules are inserted between the spokes 17a of the indexing wheel 17, the progressive rotation of the wheel 17 causes the cavities to be at least partially flattened or interspersed between the enlarged hub 18 of the indexing wheel 17 and the casing 11 of the device. The advantage of crushing at least partially the cavities of the empty ampoules is that they then absorb less space when spiraled into the used ampoule chamber of the device since the spiral strip has a smaller diameter. In addition, a natural curvature is imparted to the strip, both as a result of being fed around the ampoule indexing wheel and as a result of crushing the ampoule cavities. This encourages the used portion of the strip to spiral more readily. It is also evident that when the ampoule cavities have been crushed, the cavity is more resilient to indent at the point where the radius of the ampoule drive wheel contacts the strip, that is, at the root where the ampoule cavity meets the rest of the ampoule. strip. Therefore, a more positive and accurate actuation of the strip is obtained when the ampoules are crushed.
    [0055] [00055] As mentioned above, the drive coupling member 57 of the inhaler of the present invention is modified in which the drive gear 16 is attached to it in place of the actuator 54 so that the drive coupling member 57 rotates in response the rotation of the drive gear 16. It must be considered that the drive gear 16 can be integrally molded with the drive coupling member 57.
    [0056] [00056] It will be appreciated from Figure 7, that the drive coupling member 57 extends into an opening 19 in a side wall of the casing 11b of the device 11 and the drive gear 16 is coupled to it in a manner which is arranged on the outer surface of said side wall, only the driving coupling member 57, the indexing wheel of the ampoule strip 17 and the ampoule strip itself being received within the housing between the wrap portions 11a, 11b .
    [0057] [00057] The actuation lever 14 has a first portion similar to the plate 20 that extends through the outer surface of the envelope 11b and has a hole 21 in it or receives a protuberance 22 that remains straight from said surface, to pivotally mount the actuation lever 14 in the casing 11 for rotation about a second geometric axis (AA in Figures 7 and 15). The actuation lever 14 may also have a second portion similar to plate 23 that is parallel to and spaced from the first portion 20 by an actuation boot 24. The second portion similar to the plate extends across the opposite surface of the wrap 11a and also has an orifice 25 for engagement with a corresponding protuberance that remains straight from said opposite surface in order to pivotably engage the actuation member 14 to the casing 11 with the actuation button extending between the plates 20, 23 and the opposite surfaces the wrap portions 11a, 11b.
    [0058] [00058] The first plate 20 has another opening 26 therein and the cover 12 is pivotally mounted on the outer casing portion 11b by a coupling such as a protrusion 80 that remains straight from a surface of the casing portion 11b that is located in a corresponding recess (not shown in Figure 7, but see hole 92 in Figure 15) in cover 12, for rotation of cover 12 around a third geometric axis. The protrusion 80 extends through the opening 26 in the actuation member 14. The opening 26 is in an arcuate shape and has a second geometry axis as its center so that when the actuation lever 14 is rotated about the second geometry axis , the protrusion 80 travels within the opening 26 without engaging the actuating member 14 and, thus, the cover 12 remains stationary. The opening 26 in the arcuate shape acts as a clearance hole for the pivotal attachment of the cover 12 to the casing 11b and, thus, to allow the rotation of the actuation lever 14 around the second geometric axis.
    [0059] [00059] A drive member (not shown) extends from an inner surface of the cover 12. The drive member is located between, and spaced from, each of the second and third geometric axis and extends in the direction to the actuation lever 14, and the actuation lever 14 includes a wall 27 for engagement by said actuation member when the cover 12 is rotated about its third geometric axis back to its closed position and after the actuation member 14 has been rotated around the second geometry axis. The drive member and wall 27 are located between the second and third geometry axes so that, in further rotation of the cover 12 back to its closed position, the drive member pushes against wall 27. The pressure of the actuating member against the wall 27 causes the actuating member 14 to rotate back to its original position, together with the cover 12 to its closed position.
    [0060] [00060] The cover 12 and the actuation lever 14 are configured so that when the cover 12 is in its closed position and the actuation lever 14 has returned to its initial position, the cover 12 overlaps the actuation button 24 which is compressed by a user to operate the device. This prevents a user from attempting to operate the device by turning the actuating member 14 before opening the cover 12.
    [0061] [00061] The actuating member 14 has a gear segment, toothed region or element 28 that combine in an actuated manner with the gear drive 16 so that the rotation of the actuation member 14 also causes the rotation of the gear drive 16 and the selective rotation of the drive member of the ampoule strip with respect to the gear drive 16 while the actuating member 14 is rotated through the initial portion of its stroke, due to the indexing mechanism described above, so that the ampoule strip is initially actuated to move the next ampoule to align with the ampoule piercing member 15. During another rotation of the actuating member 14 through the second portion of its course, the ampoule strip is prevented from moving as the drive coupling 57 is decoupled from the drive wheel of the ampoule strip 17. During rotation through the second portion of its travel, the ampoule piercing member 15 carried by the nozzle 13 is rotated so that it punctures the aligned ampoule, and now stationary.
    [0062] [00062] A cam drive member (not shown) extends from the first plate 20 to the second plate 23. The cam drive member is received in a groove or cam slot 29 formed in a peripheral wall 30 depending on the nozzle 13. As is evident from Figure 7, the cam groove or slot 29 has an arcuate portion 29a followed by a leg portion 29b at one end. It will be appreciated that the slot 29 can alternatively be provided in the actuation lever 14 and the cam drive member can extend from the nozzle 13 to obtain the same function.
    [0063] [00063] During the initial rotation of the actuation member 14 through the first portion of its travel, the cam drive member slides along the arcuate portion 29 of the cam slot 29 without causing any movement of the nozzle 13, since the arcuate portion 29a of cam slot 29 has the second geometry axis in its radius. However, during subsequent rotation of the actuating member 14, the cam member reaches the leg portion 29b of the cam slot 29 and engages the side walls of the cam groove 29 so as to cause the nozzle 13 to rotate around the first geometric axis BB together with the actuating member 14, thus pulling the ampoule piercing member 15, depending on the nozzle 13, towards the aligned ampoule.
    [0064] [00064] Although reference is made to a pivoting nozzle 13, it will also be appreciated that, in an alternative embodiment, the ampoule drive member 15 can be pivotally attached to a nozzle 13 or mounted on a support or module that is pivotally attached to the nozzle 13. In these embodiments, the nozzle 13 itself remains stationary so that, in response to the operation of the actuating member 14, the ampoule driving member 15 pivots with respect to the stationary nozzle 13 to pierce the lid of an aligned ampoule .
    [0065] [00065] During the rotation of the cover 12 from its open position to its closed position, the rotation of the actuating member 14 due to the rotation of the cover 12 also causes the nozzle to rotate back to its original position as the cam member travels back along cam slot 29b.
    [0066] [00066] As described in Figure 7, a spiral element 31 is also optionally mounted within the housing 11 into which the used portion of the strip is fed.
    [0067] [00067] Although a region is provided within the housing 11 to receive the used portion of the strip, it will be appreciated that the invention is also applicable to other inhalation devices (not shown) in which the used ampoules are not retained within the housing 11, but pass out through an opening (not shown) in the housing wall 11 for periodic detachment by a user.
    [0068] [00068] Although the perforation of a strip aligns only occurs after the movement of the strip has stopped, it is provided that the mechanism can be configured so that the decoupling of the drive wheel from the ampoule strip 17 and the drive coupling member 57 it only occurs after the ampoule piercing member 15 has pierced, or has begun to pierce the cap of an ampoule, so that the piercing element is extracted through and through the cap of the ampoule as it enters it. This creates a larger orifice in relation to the size of the orifice created when the strip is stationary before being pierced by the ampoule piercing element. A larger orifice can advantageously ensure that the entire dose of the drug is introduced and removed from the ampoule.
    [0069] [00069] A modified modality is shown in Figures 15 and 16. This modality is similar to the previous modality and works in the same way, but, in addition, it includes a retention mechanism to retain the actuation lever 81 at the end of its stroke. so that a small force must be applied to it to overcome the retention placed on it by the retention mechanism to allow the actuation lever 81 to return to its initial position. The retention mechanism includes a cantilever 82 that extends from the actuation lever 81 and has a twisted region 82a that engages with a claw 83 over the casing portion 84b as the actuation lever 81 addresses the end of the second portion of its course, so that the cantilever 82 is resiliently deformed and as it travels over the twisted region 82a and bounces back to its original shape once the jaw 83 has removed the twisted region 82a. When the actuation lever 81 is turned back to its initial position, sufficient force must initially be applied to the actuation lever 81 so that the cantilever 82 is deformed by the jaw 83 and travels back over it. In addition, by providing a slight resistance to the initial movement of the actuation lever 81, it also generates an audible "click" as the end of the second portion of the stroke of the actuation lever 81 is reached and thus provides a signal audible to the user that the end of the travel lever 81 has been reached.
    [0070] [00070] The modality also includes a rigid partition wall 85 that separates the interior of the housing in a chamber of unused and used capsules 86, 87 (see Figure 16). The wall 85 is slidably mounted within the wrapping portion 84a of the housing so that the more of the ampoules are used, the force of the ampoule spiral used in the used ampoule chamber 86 compresses against the wall 85 and pushes it into the direction indicated by the arrow "P" in Figure 16, to increase the space for used ampoules and to reduce the space previously occupied by unused ampoules.
    [0071] [00071] The sliding wall 85 comprises an elongated foot 88 that is attached to integrally formed with a deflector 89 that divides the compartment. An approximate central region 88a of the foot 88 is attached to the baffle 89 so that it extends in opposite directions on either side of the baffle 89. The foot 88 is slidably received in a recess 90 formed in a wall of the housing and is more wider at its ends 88b than at its center 88a where it joins the baffle 89 so that contact with the walls of the recess 90 is made primarily with the wider ends 88b of the foot 88.
    [0072] [00072] A deeper, narrower recess 91 may extend deeper into the wall within the first recess 90 to receive a reinforcement rib (not shown) depending on the underside of the foot 88.
    [0073] [00073] As indicated above, the drive strip of the ampoule strip 17 is rotatably mounted in the chamber to sequentially move each ampoule to a position where it can be opened, preferably using an ampoule piercing element that pierces the lid of a lined bulb. However, the drive gear 16, which is driven to rotate the drive strip of the ampoule strip 17, is arranged on the outside of the housing away from the chamber in which the strip of ampoules and the drive wheel of the ampoule strip 17 are received.
    [0074] [00074] Similarly, the actuation lever 14 is disposed outside the housing and is distant from the chamber. The drive gear segment or element 28 on the actuation lever 14, therefore, is also outside the housing, away from the chamber. This has the advantage that any loose powder dose contained in the chamber is substantially prevented from contacting gear segment 28 and drive gear 16, which can increase friction and be detrimental to satisfactory ampoule indexing.
    [0075] [00075] The respective driving gears, namely, the driving gear 16 and the gear segment 28, are arranged between the housing 11 and the cover 12 so as to be closed by said cover 12 which includes the portions 12, 12b which extend across the respective side wall surfaces of the housing 11. This means that the drive gear 16 and the gear segment 28 are arranged between one of said side wall surfaces and one of said cover portions 12a, 12b.
    [0076] [00076] The drive gear 16 is connected to the drive wheel of the ampoule strip 17, by the drive coupling member 57, through the opening 19 in the side wall of the housing.
    [0077] [00077] It will also be appreciated that the nozzle is mounted outside the housing, said peripheral wall 30 extending from opposite edges that extend through the respective side wall surfaces outside the housing away from the chamber. The peripheral walls are pivotally mounted to the side wall surfaces of the housing and are covered by a portion 12a of the cover 12.
    [0078] [00078] Another modified modality will now be described with reference to Figures 17a to 17f. This modality is similar to the previous modalities and as well as the components will not be described again. The inhaler of Figures 17a to 17d is furthermore provided with a shutter 100 (see Figures 17e and 17f) which blocks the nozzle 13 when the nozzle 13 is in its elevated position, but which pivots as the nozzle 13 is pulled down in response to pressure on the actuation lever 14, 81 to pierce an ampoule so that the nozzle 13 is opened to let a dose pass through it when the patient inhales.
    [0079] [00079] A top perspective view of the inhaler according to this embodiment can be seen in Figure 17a. A corresponding side elevation view is shown in Figure 17b, but with the cover 12 removed for clarity. In Figure 17a, the cover 12 is pivoted into its open position, but the actuation lever 14, 81 has not yet been activated. As seen in Figure 17a, the nozzle 13 is blocked by a plug portion 101 of a plug component 100 that is visible through the nozzle opening 13a.
    [0080] [00080] A top perspective view of the inhaler according to the embodiment can also be seen in Figure 17c, along with a corresponding side view in Figure 17d (with the cover 12 removed for clarity). However, in these views, the actuating lever 14, 81 is pivoted across the full length of its stroke so that the nozzle 13 is driven downward and rotated around its pivot 'B'.
    [0081] [00081] With reference to Figures 17b and 17d, it will be appreciated that the obturator 100 is represented in dashed lines to indicate that it is positioned under the nozzle 13 so that it is located between the nozzle 13 and a case study (casework) 11 and thus only part of the shutter position 101 is visible to a user through the nozzle opening 13a.
    [0082] [00082] The plug portion 101 extends from one end of a pivot arm 102 and is arcuate in shape. A first section 101a of the arcuate plug portion 101, extending directly from the pivot arm 102, is solid so that it completely blocks the nozzle opening 13a, while a second section 101b of the plug portion 101 that extends to from the first section 101a, distant from the pivot arm 102, it is provided with openings 103, which form a mesh for passing a dose introduced outside the mouthpiece 13 and into the patient's mouth, although a separate stationary mesh is envisaged it can be formed integrally with the nozzle 13 below the first section 101a, in which case the second portion 101b of the obturator arm 101 is not required.
    [0083] [00083] The opposite end 104 of the pivot arm 102, away from the plug portion 101, is pivotally mounted on the nozzle 13 for rotation about the 'X' axis. The end 104 has an enlarged region with respect to the rest of the pivot arm 102 and which extends laterally from the pivot axis 'X'. A cam slot 105 is formed in the enlarged region to receive a fixed cam pin 106 which remains straight from the case study 11. Cam pin 106 is free to slide into the slot 105.
    [0084] [00084] The arrangement is such that, as the nozzle 13 rotates around its pivot axis 'B' in response to the pressure applied to the actuation lever 14, 81, the shutter 100 also rotates around its 'X' axis due to the interaction between the fixed cam pin 106 and the cam slot 105. The plug 100 is thus rotated to its position shown in Figures 17a and 17d, where the second portion 101b of the plug portion 101 is aligned with the aperture of nozzle 13a to allow the passage of an introduced dose through the nozzle opening 13a.
    [0085] [00085] The plug 100 rotates in the opposite direction when the nozzle 13 pivots back to its original position in response to the cap 12 being closed (due to the rotation of the nozzle 13 in the opposite direction as driven by the cap 12), thereby moving the cap. first plug portion 101 back to the nozzle opening 13a and blocking the nozzle 13.
    [0086] [00086] Since the obturator is no longer visible through the mouthpiece opening 13a, the dose is punctured and ready to be inhaled. The shutter 100 also provides more protection for the mouthpiece (in addition to the cover 12) against the ingress of dust or debris into the inhaler that can occur if, for example, cover 12 was pivoted to its open position and the inhaler was left in this state, with the nozzle 13 shown, before pressing the actuation lever 14, 81 to pierce an aligned ampoule.
    [0087] [00087] Since the plug 100 is pivotally mounted to the nozzle 13 and not to the case study 11, the plug portions 101a, 101b always maintain the same distance for the opening of the nozzle regardless of the rotational displacement of the nozzle 13 so that the portions arcuate shutter holes always remain in the same closing clearance for the corresponding surfaces on the nozzle 13.
    [0088] [00088] Many modifications and variations of the invention that are within the terms of the following claims will be apparent to those skilled in the art and the above description should be considered as a description of the preferred embodiments of the invention only. For example, although reference is made to a "mouthpiece", the invention is also applicable to devices where the dose is inhaled through the nasal passages. Therefore, for the purposes of this report, the term "mouthpiece" should also be interpreted to include within its scope a tube that is inserted into a patient's nasal passages for inhalation through it.
    [0089] [00089] Furthermore, although the ampoule piercing member 15 is described as being attached to the nozzle so that the nozzle 13 and the ampoule piercing member rotate together, it is also envisaged that the nozzle itself can remain stationary and the ampoule piercing member 15 can be pivotally mounted to the nozzle 13 so that the ampoule piercing member 15 rotates with respect to the nozzle 13 to pierce the lid of an aligned ampoule.
    [0090] [00090] In another modality, the cover and the actuation member can be combined in a single component so that the rotation of the cover also causes the indexing of the strip and the perforation of an aligned ampoule.
    [0091] [00091] It will be appreciated that the inhaler of the invention can be any passive or active device. In a passive device, the dose is introduced into an air flow caused when the user inhales through the mouthpiece. However, in an active device, the inhaler may include means for generating a flow of gas or pressurized air through the ampoule to introduce a dose and transport it out of the ampoule through the mouthpiece and into the user's airway. In one embodiment, the inhaler may be provided with a source of gas or pressurized air into the housing.
    权利要求:
    Claims (7)
    [0001]
    Inhaler (10) comprising a housing (11) for receiving a strip having a plurality of ampoules, each ampoule having a perforable cap and containing a dose of medicine for inhalation by a user, a mouthpiece (13) mounted on the housing (11) and through which a dose of medicine is inhaled by a user, an ampoule piercing member (15) mounted for rotation about a first geometry axis and an actuation mechanism including an actuation lever (14.81) mounted for rotation about a second geometrical axis to sequentially move each ampoule in alignment with the ampoule piercing member (15), where the actuation lever (14,81) cooperates with the ampoule piercing member (15) so that the ampoule piercing member (15) pivots around the first geometrical axis in response to the rotation of the actuating member from an initial position around the second geometrical axis to pierce the lid of an aligned ampoule, thus a flow in air through the ampoule is generated to introduce the dose contained in it and transport it, through the mouthpiece (13), into the user's airways when a user inhales through the mouthpiece (13), the inhaler still comprising a cover (12 ) and a coupling (80) articulating the cover (12) to the housing (11) for rotation about a third axis, the cover (12) covering the nozzle (13) in a closed position, characterized by the fact that that the housing (11) comprises a casing (11a, 11b) and the actuation lever (14.81) is mounted for rotation about the second geometric axis around the casing (11a, 11b) and includes a mounting plate ( 20,23) which extends within a space between the wrap (11a, 11b) and the cover (12).
    [0002]
    Inhaler (10), according to claim 1, characterized by the fact that the actuation lever (14,81) comprises a button (24) extending from the plate (20,23) and protruding outwards space to enable the actuation lever (14.81) to be actuated by a user.
    [0003]
    Inhaler (10), according to claim 1 or 2, characterized by the fact that the actuation lever (14,81) comprises an arcuate opening (26) extending around the second geometric axis, the coupling ( 80) hingedly assembling the cover (12) to the housing (11) extends through the opening (26) so that the coupling (80) travels along the opening in an arcuate shape (26) as far as the lever actuation (14) pivot around the second geometric axis.
    [0004]
    Inhaler (10), according to claim 3, characterized by the fact that the cover (12) and the actuation lever (81) include a means of cooperation configured so that when the cover (12) is rotated from its open position back to its closed position where it covers the nozzle (13), the actuating lever (81) is rotated back to its initial position.
    [0005]
    Inhaler (10), according to claim 4, characterized by the fact that the means of cooperation comprises a wall (27) on the actuation lever (81) and an actuation member depending from the cover (12) towards the actuation lever (81), the wall (27) and sense drive member positioned between the second and third geometric axes so that the drive member engages the wall (27) when the cover (12) is rotated in a direction of returns to its closed position to rotate the actuating member about the second geometry axis back to its initial position.
    [0006]
    Inhaler (10) according to any one of the preceding claims, characterized by the fact that it comprises a retention mechanism including a cantilever arm (82) on the actuation lever (81) and a claw (83) on the wrap ( 11a, 11b), the arm (82) being resiliently deformed by the claw (83) as the actuation lever (81) reaches the end of the second portion of its stroke, to hold the actuation lever in position until the cover (12) be closed.
    [0007]
    Inhaler (10) according to claim 6, characterized in that the cantilevered arm (82) includes a twisted portion (82a) that fits over the claw (83) when the actuation lever (81) is turned towards the end portion of its course.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112013013026B1|2021-03-23|INHALER
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    WO2013175177A1|2013-11-28|Inhaler
    AU2014253494B2|2016-01-21|Inhaler
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    EP2708255B1|2015-03-25|
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    法律状态:
    2018-07-10| B12F| Appeal: other appeals|
    2020-02-27| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2020-09-29| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2021-02-09| B09A| Decision: intention to grant|
    2021-03-23| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    GBGB1020130.9A|GB201020130D0|2010-11-26|2010-11-26|Inhaler|
    GB1020130.9|2010-11-26|
    GB1109493.5|2011-06-07|
    GB1109493.5A|GB2485858A|2010-11-26|2011-06-07|Inhaler with blister piercing mechanism|
    GB1115000.0|2011-08-31|
    GB1115000.0A|GB2485867A|2010-11-26|2011-08-31|Inhaler|
    PCT/GB2011/052338|WO2012069854A2|2010-11-26|2011-11-25|Inhaler|
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