• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    bone marrow collection device that has a flexible needle. it is a bone marrow collection device that includes a flexible bone marrow collection needle that can bend during the operation to prevent the tip of the needle from piercing the internal cortical wall of the target bone. the needle defines a suction channel that defines an inlet end that is lowered to reduce the occurrences that the suction channel will be obstructed by particles of bones or other debris within the spongy portion.
    公开号:BR112013006813B1
    申请号:R112013006813-2
    申请日:2011-10-05
    公开日:2020-09-29
    发明作者:Kortney Wawrzyniak；Peter Kurzyna；Michael Lehmicke；Sean Kerr；John Maurice Marthaler；Steven Paul Parmelee
    申请人:Synthes Gmbh；
    IPC主号:
    专利说明:

    BACKGROUND
    [0001] Referring to Figure 1, conventional bone marrow collection devices typically include a rigid and straight Jamshidi needle 20, which typically defines an elongated hollow tube 22 that has a cutting tip 24 at a distal end, a handle at an opposite proximal end (not shown) and a syringe or other suitable receptacle that is in fluid communication with tube 22. During the operation, a trocar is typically conducted through the hard cortex of a target bone 30, and needle 20 is then inserted through cannulation of the trocar and into the spongy portion 28 of bone 30. Negative pressure is induced at needle 20 to aspirate bone marrow 26 from spongy portion 28 of target bone 30 through needle 20 and into the receptacle .
    [0002] It has been revealed that rigid bone marrow collection needles risk inadvertently puncturing the cortical wall of the target bone during advancement through the spongy portion of the target bone, particularly when the bone marrow collection needle is being activated at along the spongy portion of a curved region of the target bone. What is desired is a bone marrow collection device that is configured to aspirate bone marrow from a target bone more reliably than conventional bone marrow collection devices. SUMMARY
    [0003] According to one embodiment, a bone marrow collection device comprises a bone marrow needle that includes a needle axis that is elongated along a central geometric axis. The needle shaft includes a shaft body that defines a suction channel that extends through the central geometric axis. The needle shaft additionally defines an entry port in fluid communication with the suction channel in order to extract the bone marrow aspirate from a target bone. The shaft body includes a flexible portion that defines a single continuous groove that extends to the shaft body. The single continuous groove extends along a substantially helical path along a length of the shaft body. The bone marrow needle additionally includes a tip that extends distally from the needle axis and a non-elastomeric coating that extends over the flexible portion and covers at least a portion of the groove. The bone marrow collection device additionally includes a trocar which includes a trocar handle and a cannulated shaft extending from the trocar handle, the cannulated shaft configured to receive slidingly at least a portion of the needle shaft and a receptacle configured to be operatively coupled to the needle in order to aspirate bone marrow from a target bone through the needle and collect the aspirated bone marrow. BRIEF DESCRIPTION OF THE DRAWINGS
    [0004] The foregoing summary, as well as the following detailed description of a preferred embodiment, is best understood when read in conjunction with the accompanying diagrammatic drawings. For the purpose of illustrating the present disclosure, reference is made to the drawings. The scope of the disclosure is not limited, however, to the specific instrumentalities revealed in the drawings. In the drawings:
    [0005] Figure 1 is a schematic side elevation view of a conventional bone marrow collection needle;
    [0006] Figure 2A is a schematic side elevation view of a bone marrow collection device built according to one modality,
    [0007] including a trocar, a bone marrow collection needle configured to aspirate bone marrow from a target bone and a receptacle configured to receive the aspirated bone marrow
    [0008] Figure 2B is a perspective view of the swap illustrated in Figure 2A;
    [0009] Figure 2C is a sectional side elevation view of the trocar illustrated in Figure 2A;
    [00010] Figure 2D is an exploded perspective view of the trocar illustrated in Figure 2A and a catheter configured to be inserted through the trocar in order to be conducted through the cortex of the target bone;
    [00011] Figure 2E is a side elevation view of a proximal end of the catheter illustrated in Figure 2D;
    [00012] Figure 2F is a side elevation view of the catheter shown in Figure 2D shown inserted through the trocar;
    [00013] Figure 2G is an exploded view of the needle and trocar shown in Figure 2A;
    [00014] Figure 2H is a perspective view of the needle inserted through the trocar shown in Figure 2G;
    [00015] Figure 3A is a perspective view of the bone marrow collection needle illustrated in Figure 2A;
    [00016] Figure 3B is a side elevation view of the bone marrow collection needle illustrated in Figure 3A;
    [00017] Figure 3C is an end elevation view of the bone marrow collection needle illustrated in Figure 3B;
    [00018] Figure 3D is a perspective view of a needle handle according to an alternative embodiment shown connected to a needle axis of the bone marrow collection needle illustrated in Figure 3A;
    [00019] Figure 3E is a top plan view of the needle handle illustrated in Figure 3D;
    [00020] Figure 3F is a sectional side elevation view taken along line 3F-3F of Figure 3E;
    [00021] Figure 4A is a side elevation view of a flexible shaft portion of the bone marrow collection needle illustrated in Figure 2A in a straight configuration;
    [00022] Figure 4B is a side elevation view of the flexible shaft portion of the bone marrow collection needle illustrated in Figure 4A shown in a flexed configuration;
    [00023] Figure 4C is an elevation view of the sectional end of the bone marrow collection needle illustrated in Figure 4B, taken along line 4C-4C;
    [00024] Figure 4D is a sectional elevation view similar to Figure 4C, but built according to an alternative embodiment;
    [00025] Figure 5A is an enlarged perspective view of a portion of the distal end of the bone marrow collection needle illustrated in Figure 2A;
    [00026] Figure 5B is another enlarged perspective view of a portion of the distal end of the bone marrow collection needle illustrated in Figure 5A;
    [00027] Figure 5C is a schematic side elevation view of the flexible shaft portion similar to Figure 4A, but constructed according to an alternative embodiment;
    [00028] Figure 5D is an enlarged side elevation view of a portion of the flexible shaft portion shown in Figure 5C, taken along line 5D. Figure 5E is an enlarged side elevation view of a portion of the axis portion. flexible similar to Figure 5D, but including a groove built according to an alternative modality;
    [00029] Figure 6A is a schematic elevation view of the bone marrow collection needle inserted into the spongy portion of a target bone in a straight configuration;
    [00030] Figure 6B is a schematic elevation view of the bone marrow collection needle inserted into the spongy portion of a target bone similar to Figure 6A, but showing the needle in a flexed configuration;
    [00031] Figure 7A is a side elevation view of a receptacle constructed according to an alternative modality, shown attached to the bone marrow collection needle illustrated in Figure 2A;
    [00032] Figure 7B is an end elevation view of a receptacle throttle actuator illustrated in Figure 7A;
    [00033] Figure 7C is a perspective view of the choke actuator shown in Figure 7 B;
    [00034] Figure 8A is a perspective view of a needle cutting tip illustrated in Figure 2A, but constructed according to another embodiment; and Figure 8B is a side elevation view of the cutting tip shown in Figure 8A. DETAILED DESCRIPTION
    [00035] Referring to Figure 2A-C, a bone marrow collection device 40 includes a cannulated trocar 42, a cannulated bone marrow collection needle 44 configured to be inserted through the trocar 42 and into a target bone in order to aspirate the bone marrow from the target bone and a receptacle 45 configured to be operatively coupled to the needle 44 in order to receive and collect the aspirated bone marrow. The target bone can be any bone that contains an adequate amount of bone marrow to be collected. According to one embodiment, the target bone can be the pelvis. As will be appreciated from the description below, at least a portion of needle 44 is flexible, thereby allowing bone marrow collection device 40 to more reliably aspirate bone marrow from target bone as opposed to bone marrow collection devices Conventional bones that have rigid needles.
    [00036] The trocar 42 includes a cannulated trocar shaft 46 that defines a proximal end 49 and a distal end 50 which is opposite the proximal end 49 along a central axis axis of the central trocar 48 which can extend substantially along a longitudinal direction L It should therefore be appreciated that the terms "proximal" "distal" and derivatives thereof as used in connection with changing 42 and components thereof are made with reference to a direction of the distal end 50 for the proximal end 49 and a direction from the proximal end 49 to the distal end 50, respectively. The trocar shaft 46 defines a trocar tip 52 at the distal end 50.
    [00037] The trocar 42 includes a trocar handle 54 coupled to the proximal end 49 of the trocar shaft 46, such that the trocar shaft 46 extends distally from the trocar handle 54. The trocar handle 54 it can be made of any polymer or any suitable alternative material and the trocar shaft 46 can be made of stainless steel, titanium or any suitable alternative material, such as a biocompatible material or a memory shaped material such as nitinol. According to the embodiment illustrated in Figure 2A to D, the trocar handle 54 includes a trocar handle body 55 that can include a plate 56 and at least one gripping member 58, such as a pair of gripping members 58 that extends outwardly, for example, proximally to the plate 56. The gripping members 58 can be separated in such a way that the trocar handle body 55 defines a bridge portion 59 connected between the gripping members 58. The handle body trocar 55 additionally includes a cannulated connector 57 that extends proximally from the bridge portion 59 in a location aligned with the cannulated axis 46. Plate 56 defines an opening 60 that extends longitudinally through the trocar handle body 55, for example, through the bridge portion 59 and the connector 57. At least a portion of the opening 60 is sized to retain the proximal end 49 of the trocar shaft 46. The plate 56 can be connected discretely with the trocar shaft 46 or can be integral with the trocar shaft 46. According to the illustrated embodiment, the trocar handle 54 is overmoulded at the proximal end 49 of the trocar shaft 46.
    [00038] The trocar axis 46 can be cannulated, such that trocar 42 defines a cannulation 47 that extends through the trocar axis 46 along the central geometric axis 48 from the proximal end 49 to the distal end 50 , in such a way that the cannulation 47 is in alignment with the opening 60 along the central geometric axis 48. According to the illustrated embodiment, the proximal end 49 ends in the trocar handle body 55, for example, in the bridge portion 59, although it should be appreciated that the proximal end 49 alternatively extends proximally out of the trocar handle 54 Referring to Figures 2D to F, the bone marrow collection device 40 may additionally include a catheter 150 which is configured to be inserted through the trocar shaft 46 in order to be conducted through the cortex of a target bone (by means of a puncture or perforation movement or any suitable alternative movement). Catheter 150 includes a catheter handle 152, a catheter shaft 154 that extends distally from catheter handle 152 and a catheter tip 155 that extends distally from catheter shaft 154.
    [00039] The catheter handle 152 includes a handle body 156 and at least one engaging member such as a pair of engaging members 158 extending from the handling body 156. According to the illustrated embodiment, the limbs latches 158 are configured as flexible flaps 160 that extend distally from the handle body 156 and are separated enough to receive the connector 57 of the change handle 54 when the catheter 150 is coupled to the trocar 42. Each engaging member 158 may additionally include an edge 162 projecting out of the distal end of the respective flexible flap 160.
    [00040] The engagement members 158 of the catheter 150 are configured to match the complementary engagement members 51 of the trocar handle 54 (see also Figures 2B to C) in order to secure the catheter 150 to the trocar 42.
    [00041] For example, the coupling members 51 of the shift lever 54 can be configured as at least one protrusion such as a pair of protrusions 53 that project inwards and thus towards each other, the from the respective internal surfaces of the gripping members 58. The protrusions 53 are separated proximally in relation to the bridge portion 59 and terminate in a separate location outwardly in relation to the connector 57. Thus, the trocar handle 54 defines respective first spans arranged between a proximal surface of the bridge portion 59 and respective distal surfaces of the protrusions 53 when the catheter 150 is removably attached when changing 42. The first span is dimensioned to receive a corresponding edge between the edges 162. The trocar handle 54 additionally defines respective second spans between the protrusions 53 and the connector 57. The second spans are dimensioned to receive the flaps 160 of the catheter 150 when the ca teter 150 is attached to trocar 42.
    [00042] The catheter shaft 154 defines an external diameter (or alternatively molded cross-section dimension) that is substantially equal to or slightly less than that of the cannulation 47 of the changing shaft 46, such that the catheter shaft 154 can be received in the cannulation 47 so that the catheter axis 154 can move inside the cannulation 47 along the longitudinal direction L. The catheter axis 154 has a length along the longitudinal direction L that is dimensioned in such a way that the catheter tip 155 protrudes distally from the trocar axis 46 when catheter 150 is attached when changing it 42. catheter tip 155 can be tapered as it extends distally according to the illustrated embodiment.
    [00043] During the operation, the catheter shaft 154 is initially inserted through the opening 60 of the trocar shaft 54 and furthermore through the cannulation 47 of the trocar shaft 46 until the catheter shaft 152 is seated against the trocar shaft 54. According to the illustrated embodiment, the catheter handle 152 is seated against the trocar handle 54 when the distal surface of the catheter handle body 156 is adjacent to the proximal surface of the trocar handle 54, which may be the proximal surface. connect 57. The catheter shaft 154 can initially be inserted into the trocar shaft 56 when the catheter handle 152 is oriented substantially perpendicular to the trocar handle 54 Consequently, the engagement member of the catheter handle 152 is free from interference with the coupling member of the trocar handle 54. In particular, the flaps 160 of the catheter handle 152 are displaced radially in relation to the projections 53 of the trocar handle 54 when the catheter shaft 154 is initially inserted through the changing shaft 46.
    [00044] Once the catheter handle 152 is seated against the trocar handle 54, one or both of the catheter handle 152 and the trocar handle 54 can be rotated relative to the other until the flexible tabs 160 of the catheter handle 152 rest against the protrusions 53 of the trocar handle 54 in the second span of the trocar handle 54. In particular, the internal surfaces of the protrusions 53 of the trocar handle 54 can be separated by a first distance and the surfaces The outer edges of the flaps 60 can be separated by a second distance that is slightly greater than the first distance.
    [00045] Consequently, the protrusions 53 induce the flaps 60 to flex inwardly towards each other in order to provide a frictional force between the flaps 60 and the protrusions 53 which removably fix the catheter handle 152 to the handle. trocar 54 The edges 162 are arranged in the first span of the trocar handle 54 between the respective protrusions 53 and the bridge portion 59. The catheter handle 152 may additionally include a pair of opposing support surfaces 164 that may be adjacent to the handle trocar 54 when the catheter handle 152 has been rotated sufficiently to match the engaging members 158 of the catheter 150 with the complementary engagement members 51 of the trocar 42. It should be appreciated that at least one of the catheter handle 152 and the trocar handle 54 can be rotated in an opposite direction to disengage the engaging members 158 and 51, such that the catheter 150 can be removed from the trocar 42.
    [00046] When catheter 150 is attached to trocar 42, catheter tip 155 protrudes distally from tip 52 of trocar axis 46. Consequently, catheter tip 155 can be placed against the cortex of the target bone and a driving force, for example, a repeated hammering force of a hammer, can be applied to the catheter handle 150, which causes the catheter tip 155, and thus also the trocar shaft 46, to move towards inside and through the cortex of the target bone. It should be appreciated that the driving force can be any suitable driving force as desired, such as a tapping force, a puncturing force, a puncturing force, or any alternative force suitable for driving the catheter tip 155 and the spindle. switch you through the cortical wall of the target bone. The trocar shaft 46 may include depth markings 89 indicating the depth at which the trocar shaft 46 has been inserted into the target bone. For example, it may be desired to insert the trocar shaft 46 into the target bone sufficiently deep to ensure that the trocar tip 52 is disposed in the spongy portion of the target bone. Once the catheter tip 155 has been guided through the cortical wall of the target bone, catheter 150 can be removed from trocar 42, such that cannulation 47 of the trocar shaft 46 provides a guide path for the needle 44 be advanced in relation to changing 44 and to the spongy portion of the target bone.
    [00047] Although catheter 150 and trocar 42 have been described according to one embodiment, it should be appreciated that the bone marrow collection device 40 can be constructed in accordance with any suitable alternative embodiment. For example, the engaging members 158 of catheter 150 and the engaging members 51 of trocar 42 can alternatively be configured as desired to removably secure catheter 150 to trocar 42. Alternatively, catheter 150 and changing 42 can be devoid of complementary coupling members, such that the driving force can be applied to catheter handle 152 when catheter handle 152 is in mechanical communication with the trocar handle 54. Alternatively, the catheter tip 155 can be guided through the cortical wall of the target bone, thereby defining a passage that extends through the cortical wall, without first inserting catheter 150 through trocar 42. In this alternative embodiment, catheter 150 can be removed from the target bone after being guided through the cortical wall and the distal end 50 of the interchange shaft 46 can be inserted subsequently through the cut wall opening lime created by the catheter 150.
    [00048] Alternatively, the bone marrow collection device 40 can be devoid of catheter 150 and trocar tip 52 can be configured to be conducted through the cortical wall of the target bone, such that cannulation 47 of the axis of trocar 46 defines the guide path for needle 44 to be advanced in relation to trocar 44 and the spongy portion of the target bone.
    [00049] Referring now to Figures 2G to 3C, needle 44 includes a cannulated needle axis 62 that defines a proximal end 66 and a distal end 68 that is opposite proximal end 66 along a geometric axis of central needle 64. It should therefore be appreciated that the terms "proximal", "distal" and derivatives thereof as used in relation to needle 44 and components thereof are made with reference to a direction from the distal end 68 to the proximal end 66 and a direction from the proximal end 66 to the distal end 68, respectively. The needle axis 62 can define any length as desired between the proximal and distal ends 66 and 68, for example, between approximately 19.05 centimeters (7.5 inches) and approximately 30.48 centimeters (12 inches), including approximately 24 , 13 centimeters (9.5 inches) according to one embodiment and approximately 27.94 centimeters (11 inches) according to another embodiment.
    [00050] The central axis 64 can extend along the longitudinal direction L when the needle axis 62 is in an uninflected or straight configuration The needle axis 62 can include a flexible needle axis body 63 that can define a first body portion such as a rigid portion 81 which can be substantially rigid and a second body portion such as a flexible portion 84 which can extend distally from the rigid portion 81.
    [00051] The needle shaft body 63 can extend substantially along the longitudinal direction L when the flexible body portion 84 is in a first non-flexed configuration. As described in more detail below, the flexible portion 84 and thus, the shaft body 63, is configured to iterate from the first non-flexed configuration to a second flexed configuration through which the central geometric axis 64 defined by at least some part until substantially the entire flexible portion 84 is displaced angularly in relation to the longitudinal direction L.
    [00052] With continued reference to Figures 2G to 3C, needle 44 includes a needle handle 70 coupled to the proximal end 66 of needle shaft 62. Needle 44 and needle handle 70 can be made of any material as desired, such as stainless steel, titanium, aluminum, polymer or the like and can be biocompatible as desired. Needle handle 70 can be constructed according to any suitable embodiment as desired. For example, according to one embodiment, handle 70 includes a needle handle body 73 that can include a plate 72 and at least one gripping member 74 such as a pair of outwardly gripping members 74 for example. for example, proximally to the plate 72. The gripping members 74 can be separated in such a way that the needle handle body 73 defines a bridge portion 76 connected between the gripping members 74. The handle 70 defines an opening 78 that extends longitudinally through the needle handle body 73, for example, through the bridge portion 76. At least a portion up to the entire opening 78 is dimensioned to retain the needle axis 62. According to the illustrated embodiment, the needle handle 70 is overmoulded at the proximal end 66 of needle shaft 62. It should be appreciated that needle handle body 73 can be discreetly connected to needle shaft 62 or can be integral with needle shaft 62 according to with any suitable modality as desired. According to one embodiment, the needle handle 70 may include a fixing member such as a snap fit 71 which facilitates attachment of the receptacle 45 to the needle 44.
    [00053] It should be further appreciated that the needle handle 70 can be constructed according to any embodiment as desired. For example, referring to Figures 3D to F, the handle body 73 extends along a transverse length defined by a pair of opposite outer ends 73a and an intermediate portion 73b connected between the outer ends 73a. The handle body 73 can be arched in such a way that the outer ends 73a are arranged distal to the intermediate portion 73b. The handle body 73 further defines a proximal end 74 and a distal end 76, through which the proximal end 74 is arched more than the distal end 76. For example, distal end 76 can be arched or can extend substantially straight. The handle body 73 can be rounded along a central needle handle geometric axis 69 that extends along the transverse path. The needle handle 70 can additionally define one or more slots 95 that extend into or through the handle body 73, in order to define an ergonomic and comfortable grip region.
    [00054] As described above with reference to Figures 3A to C, handle 70 defines an opening 78 that extends through handle body 73 and is configured to retain the proximal end 66 of needle shaft 62. For example, as illustrated in Figures 3D to F, aperture 78 may include a proximal portion 78a and a distal portion 78b which is arranged distally with respect to the proximal portion 78a. The distal portion 78b can be sized to retain the proximal end 66 of the needle shaft 62. For example, the handle body 73 can be overmoulded at the proximal end 66 of the needle shaft 62. Alternatively, the handle body 73 can retain at least one fastener, such as a pair of pins 79 that can extend through the distal portion 78b of the opening 78 and through the proximal end 66 of the needle shaft 62 so as to secure the needle handle 73 to the needle shaft 62 Thus, distal portion 78b can be dimensioned differently from needle axis 62. For example, distal portion 78b can be substantially hexagonal in shape or can define any suitable geometry as desired. The proximal portion 78a can also define any suitable size and shape as desired. For example, according to the illustrated embodiment, the proximal portion 78a can be round, such as substantially cylindrical and can define a beveled entry 78c at the proximal end of the proximal portion 78a. As described in more detail below, handle 70 is configured to retain receptacle 45 in opening 78 and thus can define a fixing member that is configured to secure receptacle 45 to needle 44.
    [00055] The longitudinal axis 64 of the needle axis 62 can coincide with the longitudinal axis 48 of the trocar 42 when the needle 44 is operatively coupled to the trocar 42 such that at least a portion of the needle axis 62 is received sliding in cannulation 47.
    [00056] As shown in Figures 5A to B, needle 44 includes a tip 82 that extends distally from needle axis 62. According to one embodiment, needle axis 62 defines a neck 88 that extends distally from the body of axis 63 and extends distally from flexible portion 84 according to the illustrated embodiment. For example, the neck 88 can extend from the distal end 68 of the shaft body 63. The neck 88 can be recessed along a radial direction that is transverse to the central geometric axis 64 of the needle shaft 62. It should It will be appreciated that the neck 88 can be separated from the flexible portion by any distance as desired, such as approximately 0.2 centimeter (0.0787 inch) according to the illustrated embodiment, however, it can be said that the neck 88 is extends distally from flexible portion 84.
    [00057] Tip 82 can extend distally from neck 88 and therefore also extends distally with respect to axis 62. For example, tip 82 extends distally with respect to flexible portion 84. Thus, the flexible portion 84 can be arranged distally with respect to the rigid portion 81 and proximally with respect to the tip 82. Alternatively, the shaft 62 can be devoid of the neck 88, such that the tip 82 extends directly from the flexible portion 84. Alternatively still , the shaft body 63 may include a rigid portion disposed distally from the flexible portion 84. It should be further appreciated that the shaft body 63 may be devoid of a rigid portion, such that a substantial whole of the shaft body 63 is flexible .
    [00058] The neck 88 can be connected between the shaft body 63 and the tip 82, for example, between the flexible portion 84 and the tip 82. Although the flexible portion 84 ends at a proximal location of the neck 88, it must be appreciated that the neck 88 can alternatively extend radially to the flexible portion 84. Furthermore, the needle axis 62 can define more than one neck 88 positioned as desired. Thus, it can be said that the needle 44 and particularly the needle axis 62 define at least one neck 88. The neck 88 can be lowered in relation to the axis body 63 in order to define a first shoulder or proximal shoulder 77 that extends substantially radially between the shaft body 63 and the neck 88 and a second distal shoulder or shoulder 75 which is opposite the proximal shoulder 77 and extends substantially radially between the tip 82 and the neck 88. The neck 88 can define a pocket 90 that can be radially cut at a location longitudinally between the opposing shoulders 75 and 77, respectively, and thus between the shaft body 63 and 0 82. In particular, the pocket 90 is radially lowered in relation to the flexible portion 84 of such that the neck 88 defines a cross-sectional dimension that is less than that of at least one portion, such as a portion that is adjacent to the neck 88 of the shaft body 63. The pocket 90 can be additionally radially lowered in re greater cross-section dimension of the tip 82 While pocket 90 extends around the entire perimeter of the neck 88, pocket 90 may alternatively extend over only a portion of the perimeter. Alternatively, needle axis 62 can define a plurality of pockets 90 that are spaced around neck 88. As described in more detail below, needle 44 defines at least one bone marrow aspirate inlet port 92 as a pair of inlet ports for bone marrow aspirates 92 extending radially to needle axis 62, for example, in pocket 90.
    [00059] Needle 44 defines a cannulation 80 that extends along the central geometric axis 64 of the shaft body 63 from the proximal end 66 through the distal end 68 of the shaft body 63. However, the cannulation 80 does not extend through the needle shaft 62 according to the illustrated embodiment, but instead ends at a location radially aligned with the inlet ports 92. The proximal end 66 of the shaft body 63 can be coupled to the receptacle 45 such that the receptacle 45 is in fluid communication with cannulation 80 and thus configured to receive bone marrow aspirated from needle 44.
    [00060] The shaft body 63 defines an external diameter (or alternatively shaped cross-section dimension) that is substantially equal to or slightly less than that of cannulation 47 of the trocar shaft 46, such that the needle shaft 62 can be slidably inserted into the cannulation 47 in the longitudinal direction when the flexible portion 84 is in the first non-flexed configuration in order to operatively couple needle 44 to trocar 42. Consequently, trocar 42 can support needle 44 as needle 44 is advanced to the spongy portion of the target bone. In particular, the shaft body 63 has a longitudinal length greater than that of the trocar shaft 46 and the needle tip 82 can be inserted distally at the proximal end 49 of the trocar shaft 46 through the cannulation 47 and out of the distal end 50 in the spongy bone portion. According to one embodiment, a first length or distal length of the flexible portion 84 extends outside the axis of the trocar 46 and a second length or proximal length of the flexible portion 84 remains disposed within the cannulation 47 of the trocar axis 46 For example, the shaft body 63 can be configured in such a way that at least approximately 0.5 centimeter (0.2 inch) of the flexible portion 84 can be arranged inside the cannulation 47 when the tip 82 protrudes approximately 8, 5 centimeters (3.35 inches) off the trocar axis 46 along the central geometric axis 64. Although the needle axis 62 and the cannulation 47 are illustrated as substantially cylindrical in shape, it should be appreciated that they can define any alternative format as desired.
    [00061] Referring also to Figures 4A to 5A, the shaft body 63 defines a radially inner surface 65 that defines the cannulation perimeter 80 and an opposite radially outer surface 67. The inner surface 65 can define any cross-sectional dimension suitable, such as a diameter, as desired, for example, between approximately 0.127 centimeter (0.05 inch) and approximately 0.254 centimeter (0.10 inch), including approximately 0.218 centimeter (0.086 inch). The outer surface 67 can define any suitable cross-sectional dimension, such as a diameter, as desired, for example, between approximately 0.178 centimeter (0.07 inch) and approximately 0.381 centimeter (0.15 inch), including approximately 0.028 centimeter ( 0.01085 inch). As described above, at least a portion up to the entire shaft body 63 is flexible and can bend, for example, in the flexible portion 84 such that a corresponding portion of the central geometric axis 64 transits extending along the longitudinal direction L to extend along a path that is offset from the longitudinal direction L. For example, the offset path can be curved. According to the illustrated embodiment, the flexible portion 84 can be inserted into the spongy bone portion of the target bone during operation of the bone marrow collection device 40. According to the illustrated embodiment, the flexible portion 84 is defined by a groove 86 which extends substantially along a helical path 91 along a length of the shaft body 63, the length of which is at least a portion up to substantially the entire shaft body 63. Groove 86 can project radially (for example , substantially perpendicular to the central geometric axis 64) to the outer surface 67 and extends along the helical path 91 which is elongated along a helical direction of the extension along the longitudinal length of the flexible portion 84. The groove 86 can end at first shoulder or proximal shoulder 77 or may end at a location separate from the first shoulder or proximal shoulder along the central geometric axis 64 by any distance with desired size, for example, approximately 0.2 centimeter (0.0787 inch).
    [00062] According to the illustrated embodiment, the helical path 91 can define a constant spacing along the longitudinal length of the flexible portion 84. Thus, the adjacent revolutions 93 of the groove 86 can be separated at a substantially constant longitudinal distance D along the length of the flexible portion 84, the length extending along the longitudinal direction L. Alternatively, the adjacent revolutions of the groove 86 can be separated into increasing or decreasing longitudinal distances in a distal direction along the length of the flexible portion 84. In addition, path 91 may be helical as described above or may define any path of suitable shape unless otherwise indicated.
    [00063] Groove 86 can be defined as a single continuous cut in the flexible portion 84 of the needle shaft 62, such that the flexible portion 84 is devoid of any additional cuts. Thus, groove 86 can be a single continuous groove, meaning that the flexible portion 84 of the needle shaft 62 can be devoid of any other grooves constructed substantially and identically to the groove 86. Thus, the flexible portion 84 of the needle shaft 62 includes groove 86 and is devoid of more than one groove 86.
    [00064] In addition, groove 86 can define a straight line as shown (see Figures 5A to B) or it can define any suitable alternative shape as desired, such as a serpentine path as illustrated For example, as shown in Figures 5C a D, groove 86 can define a plurality of joints 130 which can define substantially dovetail joints that include a plurality of tabs 132 and a plurality of recesses 134 that retain tabs 132, such that tabs 132 are movable in the recesses 134. According to the illustrated embodiment, only a small portion to a totality of the tabs 132 extends outwardly along a direction to the respective recesses. For example, each of the tabs 132 defines a neck 136 that extends into the corresponding recess 134, an end wall 138 opposite the neck and disposed in the corresponding recess 134 and a pair of opposite side walls 140 that are connected between the neck 136 and the end wall 138. The side walls 140 are separated along a direction substantially parallel to the helical path 91 and can extend away from each other along a direction to the respective recess 134, such that the walls sidewalls 140 extend away from each other along a direction from the neck 136 to the end wall 138. The end walls 138 may extend along a direction substantially parallel to the helical path 91, such that the line extending perpendicularly to the helical path 91 can divide dovetail joints 130. Consequently, when a torsional force is applied to the needle axis 62 and thus to the flexible portion 84, the adjacent side walls 140 of the adjacent hinges 130 can go against each other in order to provide a holding force which induces the respective tongues 132 into the corresponding recesses 134. Alternatively , referring to Figure 5E, the side walls 140 of each joint 130 can extend substantially parallel to each other along a direction between the neck 138 and the end wall 138. The helical path 91 can define an angle and at with respect to a plane P that extends substantially perpendicular to the central geometric axis 64. The angle e can be as desired, such as between approximately 10.5 degrees and approximately 13.5 degrees and, for example, approximately 12 degrees.
    [00065] According to the illustrated embodiment, the side walls 140 are curved and define radii of curvature at the interface with the end wall 138. For example, the radius of curvature defined at the interface with the end wall 138 and each of the side walls 140 can be approximately 0.014 centimeter (0.0054 inch) or any suitable alternative dimension as desired. The center of the rays can be spaced by any suitable distance such as approximately 0.071 cm (0.0285 inch). Adjacent end walls 138 can be separated along a direction substantially perpendicular to the helical path by any suitable distance as desired, such as approximately 0.053 cm (0.021 inch). The hinges 130 can define one or more curved surfaces at the interface between the end walls 138 and the side walls 140. For example, the curved surfaces can be defined by any suitable radius as desired, such as approximately 0.014 centimeter (0.0054 inch) ). The radius center of each joint can be spaced any distance as desired, such as approximately 0.071 cm (0.0285 inch). Alternatively, the interface between the end walls 138 and the side walls 140 can define substantially straight and angled surfaces. It should be appreciated that the side walls 140 may alternatively extend substantially straight or include straight angled segments as desired.
    [00066] According to the illustrated embodiment, the groove 86 can define any suitable number of joints 130 along a revolution on the needle axis 62 along the helical path. The groove can define more than 4.5 and less than 20, for example, between approximately 4.8 and approximately 5.0 cycles per revolution 93 on needle axis 62. That is, groove 86 can define approximately 5.0 segments S defined between the respective midpoints of the adjacent end walls which are separated along a direction substantially parallel to the helical path 91 along a single revolution 93 on the needle axis 62. According to an alternative embodiment, the groove 86 can define approximately 12.0 cycles per revolution on needle axis 62. Flexible portion 84 and rigid portion 81 can define any suitable external cross-section dimension, such as a diameter, of approximately 0.274 cm (0.1085 inch) ) as described above and any suitable internal cross-sectional dimension, such as a diameter, of approximately 0.216 centimeter (0.085 inch) as described above. In addition, helical path 91 can define any suitable spacing as desired, such as a distance of approximately 0.193 centimeter (0.0762 inch) that extends along a direction substantially parallel to the central geometric axis 46 between adjacent revolutions 93. The dovetail joints 61 can define a height, for example, the distance between the neck 136 and the corresponding end wall 138 as desired, for example, approximately 0.533 cm (0.21 inch).
    [00067] When the central geometric axis 64 extends along the longitudinal direction L, for example, when the flexible portion 84 is in the non-flexed configuration, the groove 86 can define any suitable thickness as desired, such as between approximately 0.013 cm ( 0.005 inch) and approximately 0.051 cm (0.02 inch), for example, approximately 0.025 cm (0.01 inch). The thickness is substantially perpendicular to the helical path along the length of the axis body that defines the helical path 91 The tongues 132 are movable in the recesses 134 along a direction that includes a directional component that is parallel to the central geometric axis 64. Thus , the flexible portion 84 can be curved in the manner described above in such a way that on one side of the flexible portion 84, the hinges 130 are placed in compression in such a way that the respective tabs 132 are further moved in the corresponding recesses 134 so as to decrease the thickness of the groove 86, while simultaneously on a radially opposite side of the flexible portion 84, the hinges 130 are placed in tension such that the respective tongues 132 are further moved out of the corresponding recesses 1 34 in order to increase the thickness of the groove 86.
    [00068] Thus, the helical groove 86 allows the flexible portion 84 of the needle shaft 62 to flex or bend in relation to the longitudinal direction L. As a result, the shaft body 63 and thus the needle shaft 62, can move from a straight configuration as shown in Figure 4A through which the needle axis 62, including the flexible portion 84, extends along the central geometry axis 64 which extends along the longitudinal direction L to a flexed configuration as shown in Figure 4B through which the flexible portion 84 and thus the central geometric axis 64 are flexed and curved in relation to the longitudinal direction L.
    [00069] According to one embodiment, the flexible portion 84 can be configured to flex at any angle as desired in relation to the longitudinal direction L. For example, the flexible portion 84 is configured to flex in order to define an angle between approximately 45 degrees and approximately 90 degrees in relation to the longitudinal direction L, including between approximately 85 degrees and approximately 90 degrees. Although the flexible portion 84 is illustrated as including the grooves 86 that extend inwardly or through the shaft body 63, the flexible portion 84 can be additionally or alternatively configured as a flexible material that extends distally from the shaft body 63. For example, flexible portion 84 may be made of polyetheretherketone (PEEK) or any alternatively flexible material and may include grooves 86 or may be devoid of grooves 86.
    [00070] Referring now to Figure 4C, according to one embodiment, the groove 86 extends radially inwardly of the outer surface 67, but does not extend through the shaft body 63 to the inner surface 65.
    [00071] Thus, as illustrated in Figure 4C, groove 86 has a depth that ends at a location between the inner and outer surfaces 65 and 67. The depth may be sufficient to impart flexibility to the shaft body 63. As a result , the inner surface 65 can be substantially smooth. Alternatively, as shown in Figure 4D, the groove 86 can extend radially through the needle shaft 62, from the outer surface 67 and through the inner surface 65 to increase the flexibility of the shaft body 63 in the flexible portion 84. According to in one embodiment, groove 86 can be laser cut on shaft body 63 although it should be appreciated that groove 86 can be formed in any suitable alternative manner as desired.
    [00072] Needle 44 can include a sheath or polymeric coating 85 that covers at least some part of the flexible portion 84 of the needle shaft 62, such as the entire flexible portion 84. The polymeric coating 85 can seal the flexible portion 84, can protect the integrity of the needle shaft 62 and can provide stability that decreases the flexibility of the flexible portion 84 as desired. Needle 44 can include polymeric liner 85 if groove 86 extends into, but not through, flexible portion 84 as shown in Figure 4C or if groove 86 extends through cannulation flexible portion 80. Liner 85 can be non-elastomeric and, for example, can be made of PEEK or any alternative non-elastomeric material. Furthermore, the coating 85 can extend over the groove 86 without extending to the groove 86.
    [00073] Referring to Figures 5A to B and as described above, the distal end 68 of the needle shaft 62 is connected to the needle tip 82. The needle tip 82 is configured to advance through the spongy portion of the target bone as desired at such a depth that the flexible portion 84 is also inserted into the spongy bone portion. The needle tip 82 can be tapered and is illustrated as a chisel tip having opposite surfaces 96 that taper towards each other as they extend distally from the neck 88 and the flexible portion 84. Alternatively, the tip 82 can be configured as a spiral drill, a round, a sharp or blunt cone, a hemisphere, a shovel or any alternative shape as desired. For example, referring to Figures 8A to B, tip 82 can define a recess 97 so as to be configured as a self-tapping top that includes at least one or more radially protruding cut grooves 99 that can be curved or shaped as desired on the central geometric axis 64 as they extend longitudinally.
    [00074] As shown in Figures 8A to B, the neck 88 can define a cross-sectional dimension along a direction perpendicular to the central geometric axis 64 which is less than the cross-sectional dimension of the needle axis 62 along a direction perpendicular to the central geometric axis 64 and thus also less than the cross-sectional dimension of the flexible portion 84 along a direction perpendicular to the central geometric axis 64, as desired. Tip 82 can define any distance from neck 88 as desired. According to one embodiment, the proximal end of the tip 82 is disposed at any distance as desired from the distal end of the cannulation 80, such as between approximately 0.05 mm and 1.5 mm, including approximately 0.07874 mm. Thus, the tip 82 can be configured to be advanced through the spongy portion of the target bone, for example, by applying an inductive force to the needle 44 in the longitudinal direction L, for example, by puncturing the needle 44, in order to guiding the needle tip 82 along a spongy portion of the target bone or applying a torsional force to the needle that causes the needle tip 82 to rotate on a geometric axis of rotation that can be defined by the central geometric axis 64 so as to guide the needle tip 82 along the spongy portion of the target bone. Alternatively, it should be appreciated that if the bone marrow collection device 40 is devoid of the catheter 150 described above, the needle tip 82 can be configured to be conducted through the cortical wall of the target bone, for example, applying to driving force to the needle handle 70 once the needle tip 82 was placed against the cortical wall.
    [00075] With continued reference to Figures 5A to B, the cannulation 80 of the shaft body 63 is in communication with the environment of the needle 44.
    [00076] In particular, as described above, needle 44 defines at least one transverse aspirate port 92 illustrated as an opening 94 that extends radially to needle axis 62 along a direction that is substantially perpendicular or angularly displaced otherwise in relation to the central geometric axis 62 of the needle axis 62. For example, according to the illustrated embodiment, the inlet port 92 extends radially to the neck 88. It should be appreciated, however, that the inlet port it can extend through any suitable location of needle 44 in communication with cannulation 80 and sufficient to receive bone marrow aspirated from the target bone. For example, according to an alternative embodiment, the inlet port 92 can extend into the tip assembly 87, such as the tip 82.
    [00077] Opening 94 extends to needle axis 62 to a depth such that opening 94 intercepts cannulation 80 and thus places inlet port 92 in fluid communication with cannulation 80. According to the illustrated embodiment , the opening 94 extends through the neck 88 in order to define a pair of opposite entrance doors 92, for example, radially opposite which can be radially opposite and in communication with the cannulation 80. The entrance doors 92 can define any area as desired, for example, greater than approximately 0.032 cm2 (0.005 in2), such as greater than approximately 0.039 cm2 (0.006 in2), and less than any value as desired, such as 0.148 cm2 (0.023 in2). Although the entrance doors 92 are illustrated as displaced angularly in relation to the cannulation 80, the cannulation 80 can be configured to extend longitudinally through the tip 82 so as to be placed in communication with the environment, in such a way that the entry 92 is coextensive with the cannulation. Thus, the needle axis 62 defines a suction channel 83 which extends through the needle body 63 and can include cannulation 80 and inlet port 92.
    [00078] As described above in relation to Figures 2A to D and with additional reference to Figures 6A to B, trocar 42 can create a passage through the cortex 98 of a target bone 100, which can be any bone that has a desired amount bone marrow to be aspirated. For example, target bone 100 can be an iliac crest, a long bone, a vertebral body, or any suitable alternative bone as desired. Referring also to Figures 6A to B, needle tip 82 can be inserted through cannulation 47 of trocar 42 and into spongy portion 102 of target bone 100. Tip 82 can be advanced into bone 100 according to a negative pressure is induced which extracts the bone marrow aspirate from the spongy portion 102 along the direction of Arrow 103. Tip 82 can be positioned such that inlet ports 92 are aligned with bone marrow 105, such that the negative pressure induced extract the bone marrow into the receptacle 45 like the bone marrow aspirate. Conventional needles 20 of the type illustrated in Figure 1, although suitable for facilitating the removal of bone marrow aspirate from the spongy portion of the bone, are not flexible and, thus, can cause damage to the cortical wall if an anatomical curvature of the bone is found and, in some occurrences, can puncture through the cortex 98. Consequently, doctors typically withdraw large volumes from a single location in the spongy portion without repositioning the needle, which typically causes the aspirated bone marrow to be diluted by a significant amount of peripheral blood that is also aspirated.
    [00079] Referring to Figures 6A to B, needle 44 has sufficient strength to advance through the spongy portion 102 of target bone 100 while allowing flexible portion 84 to flex to the outline of an anatomical curvature 103 of bone 100. Consequently, tip 82 is configured to advance in spongy portion 102 without puncturing inside or through the inner surface of cortex 98. Consequently, tip 82 can be guided further into spongy portion 102 compared to conventional needles and can reach the spinal cord bone that was previously unattainable due to the curvature, for example, of the iliac crest. As a result, needle 44 can extract a greater proportion of bone marrow aspirate in relation to peripheral blood than conventional needles. In addition, the entrance doors 92 are lowered in relation to the shoulders 75 and 77 of the tip 82 and needle body 63, thereby reducing the occurrences in which the entrance doors 92 will be obstructed by fragments of bone or other debris disposed inside the spongy portion 102.
    [00080] Referring again to Figure 2A, the receptacle 45 can be provided as a syringe 104 that includes a barrel 106 that defines an inner void 108 that is in fluid communication with the suction channel 83 when the receptacle 45 is coupled to needle 44. Barrel 106 has a tip 110 at one end that is configured to be placed in fluid communication with needle 44 and is closed by a plunger 112 at an opposite end. Tip 110 can be configured to operatively couple syringe 104 to needle 44 in such a way that the inner void 108 is in fluid communication with the cannulation 80. Consequently, the plunger 1 12, which is movably coupled to the barrel 106 can be manually extracted proximally in relation to barrel 106 in order to induce negative pressure in the suction channel 83 which causes the bone marrow to be extracted through the suction channel 83 and into the interior empty space 108. According to In the illustrated modality, the bone marrow aspirate is extracted through the entrance ports 92, for cannulation and travels proximally to the interior empty space 108.
    [00081] Alternatively, referring to Figures 7A to C, the receptacle can be coupled to a suction tool 1 16 which has a motor 1 18, a syringe 104 and a conduit 120 that couples motor 1 18 to syringe 104. The motor 118 can be a stepper motor that induces a vacuum in the suction channel 83 in the manner described above, which causes the bone marrow aspirate to travel through the conduit 120 and into the barrel 106. The suction tool 116 may include a activator in the form of a pushbutton 122 and an opposite clamp 123 that carries the conduit 120 The pushbutton 122 is coupled to a crimp member 124 configured to be driven downward in the conduit 120 when the pushbutton 122 is pressed, thereby blocking the channel between needle 44 and receptacle 45 and restricting or preventing the flow of suction through conduit 120 to barrel 106. For example, push button 122 can be pressed to block suction as tip 82 is is being repositioned on the target bone.
    [00082] It should be noted that the illustrations and discussions of the modalities shown in the figures are for exemplary purposes only and should not be interpreted limiting the disclosure. One skilled in the art will appreciate that the present disclosure contemplates several modalities. It should be further appreciated that the features and structures described and illustrated according to one modality may apply to all modalities as described in this document, unless otherwise indicated. Additionally, it should be understood that the concepts described above with the modalities described above can be used alone or in combination with any of the other modalities described above.
    权利要求:
    Claims (15)
    [0001]
    1. Bone marrow collection device (40), comprising: a bone marrow needle (44) which includes: a needle axis (62) which is elongated along a central axis (64), the needle axis (62) including a shaft body (63), the needle shaft (62) defining a suction channel (83) which extends through the shaft body (63) along the central axis (64), being that the needle axis (62) further defines an entrance port (92) in fluid communication with the suction channel (83) in order to extract the bone marrow aspirate from a target bone (100), in which the body of shaft (63) includes a flexible portion (84) that defines a groove (86) that extends to the shaft body (63); a tip (82) extending distally from the needle axis (62); and a non-elastomeric coating (85) that extends over the flexible portion (84) and covers at least a portion of the groove (86); and a trocar (42) which includes a trocar handle (54) and a cannulated trocar shaft (46) extending from the trocar handle (54), the cannulated shaft (46) configured to receive slidingly through the minus a portion of the needle shaft (62), characterized by the fact that the groove (86) is a single continuous groove (86) that extends along a helical path (91) along a length of the shaft body (63).
    [0002]
    2. Bone marrow collection device, according to claim 1, characterized by the fact that the groove (86) extends through the shaft body (63) to the suction channel (83).
    [0003]
    Bone marrow collection device according to claim 1 or 2, characterized in that the flexible portion (84) comprises a flexible material.
    [0004]
    4. Bone marrow collection device according to claims 1 to 3, characterized by the fact that the needle axis (62) defines a neck (88) that is lowered in relation to the flexible portion (84) and the port inlet (92) extends through the recessed neck (88), where preferably the neck (88) is arranged between the flexible portion (84) and the tip (82).
    [0005]
    5. Bone marrow collection device according to claims 1 to 4, characterized by the fact that the non-elastomeric lining (85) does not extend into the groove (86), in which the non-elastomeric lining (85) is made of PEEK ..
    [0006]
    6. Bone marrow collection device according to claims 1 to 5, characterized by the fact that the groove (86) is straight or defines a serpentine shape.
    [0007]
    7. Bone marrow collection device according to claim 6, characterized by the fact that the groove (86) defines a serpentine shape and a joint (130) that includes a plurality of tongues (132) and corresponding recesses ( 134) that retain the tabs (132), such that the tabs (132) are movable in the recesses (134) along a direction that includes a directional component that is parallel to the central axis (64).
    [0008]
    8. Bone marrow collection device according to claim 7, characterized by the fact that the joint (130) defines a dovetail shape, so that at least a portion of the tongues (132) extends outward along a direction to the respective recesses (134), where preferably the flexible portion (84) defines more than 4.5 and less than 20 dovetail joints (130) per revolution on the needle axis (62), where the flexible portion (84) defines between 4.8 and 5.0 dovetail joints (130) over a single revolution on the needle axis (62), or where the tongue (132) defines opposite side walls (140) which are separated along a direction parallel to the helical path (91) and the opposite side walls (140) extend parallel to each other.
    [0009]
    9. Bone marrow collection device according to claim 7 or 8, characterized by the fact that the groove (86) defines a thickness between 0.013 centimeter (0.005 inch) and 0.05 centimeter (0.02 inch), preferably 0.025 centimeter (0.01 inch) where the thickness is transverse to the helical path (91) along the length of the shaft body (63).
    [0010]
    10. Bone marrow collection device, according to claim 9, characterized by the fact that the helical path (91) defines an angle between 10.5 degrees and 13.5 degrees, preferably 12 degrees, in relation to a plane which extends perpendicular to the central axis (64).
    [0011]
    Bone marrow collection device according to claims 1 to 10, characterized in that the bone marrow needle (44) additionally includes a needle handle (70) coupled to the needle shaft (62).
    [0012]
    12. Bone marrow collection device according to claims 1 to 11, characterized by the fact that it still comprises a catheter (150) that includes a catheter handle (152), a catheter shaft (154) that extends from the catheter handle (152) and a catheter tip (155) extending from the catheter shaft (154), where the catheter tip (155) is configured to be conducted through a cortical wall of the target bone (100), where preferably the catheter axis (154) is dimensioned to extend through the cannulated trocar axis (46) in such a way that the catheter tip (155) protrudes outwardly in relation to the axis of trocar (46).
    [0013]
    13. Bone marrow collection device according to claims 1 to 12, characterized in that 0.5 centimeter (0.2 inch) of the flexible portion (84) can be arranged inside the cannulated trocar shaft ( 46) when the tip (82) protrudes 8.5 centimeters (3.35 inches) out of the trocar axis (46) along the central axis (64).
    [0014]
    14. Bone marrow collection device according to claims 1 to 13, characterized by the fact that the cannulated trocar shaft (46) defines a proximal end (49) and a distal end (50) which is separate from the end proximal (49) along a central axis (48) extending along a longitudinal direction (L), and the flexible portion (84) is configured to flex in order to define an angle between 45 degrees and 90 degrees, preferably between 85 degrees and 90 degrees, in relation to the longitudinal direction (L).
    [0015]
    15. Bone marrow collection device according to claims 1 to 14, characterized by the fact that it still comprises a receptacle (45) configured to be operatively coupled to the needle (44) in order to suck bone marrow from a bone target (100) through the needle (44) and collect the aspirated bone marrow, in which preferably the receptacle (45) includes a barrel (106) that defines an interior empty space (108) in fluid communication with the channel (83) and a movable piston (112) fixed to the barrel (106), so that the movement of the piston (112) induces a negative pressure in the channel (83).
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    同族专利:
    公开号 | 公开日
    JP2014504890A|2014-02-27|
    KR101908148B1|2018-10-15|
    TWI536949B|2016-06-11|
    KR20130133180A|2013-12-06|
    EP2624762B1|2016-01-13|
    CN103153201A|2013-06-12|
    CA2813739A1|2012-04-12|
    JP6038034B2|2016-12-07|
    WO2012047984A1|2012-04-12|
    CA2813739C|2019-01-08|
    BR112013006813A2|2016-07-12|
    US8852119B2|2014-10-07|
    EP2624762A1|2013-08-14|
    TW201231009A|2012-08-01|
    CN103153201B|2016-06-29|
    US20120116247A1|2012-05-10|
    WO2012047984A8|2012-08-09|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US2515365A|1947-03-31|1950-07-18|Edward Adolphus Zublin|Flexible drill pipe|
    US4142517A|1976-07-23|1979-03-06|Contreras Guerrero De Stavropo|Apparatus for extracting bone marrow specimens|
    US4469109A|1981-12-24|1984-09-04|Creative Research And Manufacturing Inc.|Bone marrow aspiration needle|
    GB2130890B|1982-11-30|1987-07-29|Downs Surgical Plc|Aspiration needle|
    US4969870A|1989-06-07|1990-11-13|The Regents Of The University Of California|Method and apparatus for intraosseous infusions|
    US5152744A|1990-02-07|1992-10-06|Smith & Nephew Dyonics|Surgical instrument|
    AU6499596A|1995-07-18|1997-02-18|Edwards, Garland U.|Flexible shaft|
    US6447518B1|1995-07-18|2002-09-10|William R. Krause|Flexible shaft components|
    US6758848B2|1998-03-03|2004-07-06|Senorx, Inc.|Apparatus and method for accessing a body site|
    US6716216B1|1998-08-14|2004-04-06|Kyphon Inc.|Systems and methods for treating vertebral bodies|
    US20070276352A1|2002-06-04|2007-11-29|Stemcor Systems, Inc.|Removable device and method for tissue disruption|
    US7462181B2|2002-06-04|2008-12-09|Stanford Office Of Technology Licensing|Device and method for rapid aspiration and collection of body tissue from within an enclosed body space|
    US7081123B2|2002-06-18|2006-07-25|Musculoskeletal Transplant Foundation|Bone marrow aspiration instrument|
    US6916292B2|2002-07-12|2005-07-12|Depuy Spine, Inc.|Bone marrow aspirator|
    DE03764480T1|2002-07-12|2005-10-20|Cook Urological Inc|FLEXIBLE CANNULA STAY|
    US7625364B2|2003-05-27|2009-12-01|Cardia, Inc.|Flexible center connection for occlusion device|
    US6890308B2|2003-06-03|2005-05-10|Abul Bashar Mohammed Anwarul Islam|Bone marrow biopsy needle|
    US7179232B2|2003-06-27|2007-02-20|Depuy Acromed, Inc.|Controlled orifice sampling needle|
    US20050159676A1|2003-08-13|2005-07-21|Taylor James D.|Targeted biopsy delivery system|
    US20050203513A1|2003-09-24|2005-09-15|Tae-Ahn Jahng|Spinal stabilization device|
    US7488322B2|2004-02-11|2009-02-10|Medtronic, Inc.|High speed surgical cutting instrument|
    US20090187116A1|2004-04-05|2009-07-23|Yasuharu Noishiki|Method for harvesting bone marrow and its medical apparatus|
    US7666189B2|2004-09-29|2010-02-23|Synthes Usa, Llc|Less invasive surgical system and methods|
    WO2006039511A2|2004-09-30|2006-04-13|Boston Scientific Scimed, Inc.|System and method of obstruction removal|
    WO2006104060A1|2005-03-29|2006-10-05|Hi-Lex Corporation|Double needle for medical treatment, bone centesis needle, and bone marrow sampling device|
    US20110004215A1|2005-09-12|2011-01-06|Bradley James P|Labrum retracting burr|
    PL1933726T3|2005-10-05|2011-02-28|Rold Orlando Da|Flexible hollow shaft|
    US20090131886A1|2007-11-16|2009-05-21|Liu Y King|Steerable vertebroplasty system|
    EP2255734A1|2009-05-29|2010-12-01|Aesculap Ag|Surgical instrument|US10231716B2|2012-10-29|2019-03-19|Endocellutions, Inc.|Apparatus and methods for aspirating tissue|
    US9913929B2|2013-10-18|2018-03-13|Fortus Medical, Inc.|Bone marrow aspirate enhanced bone graft|
    WO2015109100A1|2014-01-15|2015-07-23|Endocellutions, Inc.|Bone marrow harvesting needle improvements|
    US9968373B1|2014-02-21|2018-05-15|Surgentec, Llc|Handles for needle assemblies|
    CN103860211B|2014-03-28|2015-07-08|山东省立医院|Centrum tumor remover|
    US9925068B2|2014-05-30|2018-03-27|Treace Medical Concepts, Inc.|Bone harvester and bone marrow removal system and method|
    EP3148445B1|2014-05-30|2019-03-13|Cook Medical Technologies LLC|Laser cut needle cannula with increased flexibility|
    US9770425B2|2014-10-09|2017-09-26|Aperture Medical Technology Llc|Implantable bone marrow access apparatus|
    US10993707B2|2014-10-17|2021-05-04|Cervos Medical Llc|Bone marrow aspiration device and method|
    WO2016137700A1|2015-02-26|2016-09-01|Boston Scientific Scimed, Inc.|Variable stiffness aspiration needle|
    WO2016183019A1|2015-05-08|2016-11-17|Fortus Medical, Inc.|Bone fragment and tissue processing system|
    EP3463104A4|2016-05-31|2019-12-11|Intuitive Surgical Operations Inc.|Pliant biopsy needle system|
    JP6917372B2|2016-07-20|2021-08-11|テルモ株式会社|Medical long body|
    JP2019165753A|2016-08-16|2019-10-03|テルモ株式会社|Medical elongated body|
    US11064980B2|2016-08-18|2021-07-20|Lenkbar, Llc|Flexible tissue collection device|
    EP3509520B1|2016-09-07|2021-07-28|Fortus Medical, Inc.|Bone void filler preparation system|
    US10568661B2|2016-09-29|2020-02-25|Endocellutions, Inc.|Bone marrow access device|
    US10448933B2|2016-10-05|2019-10-22|Aperture Medical Technology Llc|Bone marrow access system|
    WO2018156107A1|2017-02-22|2018-08-30|Spiration, Inc. D.B.A.Olympus Respiratory America|Improved jacket flexible needle assembly|
    EP3634245A4|2017-06-07|2021-03-17|Fortus Medical, Inc.|Connective tissue progenitor cell aspiration and processing system|
    CN108187156A|2018-01-25|2018-06-22|哈尔滨医科大学|Suction device in intervertenral space under Percutaneous endoscopic|
    WO2020019310A1|2018-07-27|2020-01-30|尚华|Intravascular puncturing system using shape memory alloy and application method thereof|
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    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-09-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-07-07| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-09-29| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/10/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US38988910P| true| 2010-10-05|2010-10-05|
    US61/389.889|2010-10-05|
    PCT/US2011/054904|WO2012047984A1|2010-10-05|2011-10-05|Bone marrow harvesting device having flexible needle|
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