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    • 专利摘要:
    mouthwash compositions with enhanced sweetness. The present invention relates to improved sweetening compositions and oral care compositions, specifically those in the form of a dental remedy or mouthwash, comprising the same. The sweetening composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of sucrose-like type and equivalence, preferably in a ratio of from about 1: to about 2. it has been found that the sweetening composition of the invention significantly optimizes. The flavor profile, long-lasting freshness and clean feel of oral care compositions provide a sweetness in use more natural and pleasant than that of artificial sweeteners alone.
    公开号:BR112013006643B1
    申请号:R112013006643
    申请日:2011-09-29
    公开日:2018-10-16
    发明作者:Schneiderman Eva；Christian Haught John；Alan Sanker Lowell；Leslie Swaine Robert Jr
    申请人:Procter & Gamble；
    IPC主号:
    专利说明:

    (54) Title: SWEETENING COMPOSITION AND ORAL COMPOSITION WITH ENHANCED SWEETNESS (51) lnt.CI .: A61K 8/60; A61Q 11/00; A61K 8/19; A61K 8/49 (30) Unionist Priority: 01/10/2010 US 61 / 388,753 (73) Holder (s): THE PROCTER & GAMBLE COMPANY (72) Inventor (s): JOHN CHRISTIAN HAUGHT; EVA SCHNEIDERMAN; LOWELL ALAN SANKER; ROBERT LESLIE SWAINE JR.
    (85) National Phase Start Date: 03/22/2013
    1/50
    SWEETENING COMPOSITION AND ORAL COMPOSITION WITH ENHANCED SWEETNESS
    FIELD OF THE INVENTION
    The present invention relates to sweetener compositions, compositions for oral treatment and methods of improving the sweetness of compositions for oral treatment. BACKGROUND OF THE INVENTION
    As a sensation, sweetness is generally recognized as a perception of sucrose and artificial sweeteners, so it has ratings in terms of sucrose equivalents. There are a wide variety of compounds that improve the feeling of sweetness. Although naturally occurring carbohydrate sweeteners such as sucrose are the most widely used sweeteners, they suffer from the disadvantages of high cost, high calorie content and the promotion of tooth decay. Artificial sweeteners are designed to overcome these problems, but they are sometimes rejected by the consumer for not having a sufficiently similar taste to sucrose. Artificial sweeteners have different sweetness profiles than sucrose and often suffer side effects, such as delays in the beginning of the perception of sweetness and / or an unpleasant aftertaste.
    Due to its contribution to dental caries, the use of natural sweeteners, such as sucrose or high fructose corn syrup, to provide superior characteristics of sweetness in compositions for oral treatment is problematic. To reduce the contribution to tooth decay, artificial sweeteners are often used to provide sweetness, although they may have undesirable tastes to consumers, such as
    Petition 870180058633, of 07/06/2018, p. 4/11
    2/50 delayed sweetness; persistent sweet aftertaste; bitter, metallic or astringent taste and / or dryness.
    For example, the sweet taste of high-potency natural and / or synthetic sweeteners is slower in the beginning and longer in duration than the sweet taste produced by sugar and thus alters the remaining flavor of a food composition. Due to these differences, the use of a high-potency natural sweetener replaces a bulk sweetener, such as sugar, in a food or drink, causes a time balance and / or flavor profile. In addition to the difference in time profile, high-potency sweeteners, in general, exhibit (i) a lower maximum response than sugar, (ii) unpleasant flavors including bitter, metallic, cooling, astringent, licorice-like flavor, etc., and / or (iii) sweetness that decreases in iterative tasting. It is well known to those skilled in the food / beverage formulation technique, that changing the sweetener in a composition requires re-balancing the flavoring and other flavor components (for example, acidulants). If the flavor profile of high-potency natural and synthetic sweeteners could be modified, to give specific desired flavor characteristics to be more similar to sugar, the type and variety of compositions that can be prepared with this sweetener would expand significantly. Consequently, it would be desirable to selectively modify the flavor characteristics of natural and synthetic high-potency sweeteners.
    The residual taste of artificial sweeteners in oral care products is particularly problematic in that many of the ingredients in oral care compositions have negative flavor attributes
    3/50 individuals. While flavoring has been used as a compensator to disguise unpleasant-tasting materials, including the sweetener, the flavoring by itself can impart a bitter taste when used at too high a level, requiring even more sweetener to overcome the flavoring. The end result can be a formula that is too bitter, too sweet, gives a negative aftertaste or is simply too expensive. The purpose of this invention is to provide an innovative combination of sweeteners that resolves the aforementioned negative attributes. This combination provides a longer lasting freshness, clean feeling, reduced bitter taste and flavor impression of any of the sweeteners alone.
    Some relevant descriptions related to the use of sweetener combinations include:
    EP 658 340 A1 which describes the compensation of the bitter taste of betaine-based surfactants with a combination of saccharin or an alternative saccharin and another sweetening agent such as thaumatin or stevioside. This document does not provide instructions for using triple sweetener combinations where the use of saccharin has been reduced, as described herein.
    US patent 2007/0116831 Al (Prakash, Dubois) describes the use in a dental composition of a high-potency sweetener composition, which comprises a natural high-potency sweetener, such as rebaudioside A and / or a high-potency sweetener synthetic, such as sucralose, in combination with a sweet taste enhancing composition and a dental active. Its objective was to create a profile more similar to sugar. In US patent 2009/0053378 Al,
    4/50
    Prakash et al., Based on US patent 2007/0116831 A1, further describe the inclusion of a sweetening enhancer, such as an aryl carboxylic acid derivative. None of these documents teaches the use of the sweetener combinations described here.
    The US patent 2009/0004360 Al (Bingley) is also concerned with the use of a sweetener modifier, in this case a (di) hydroxy benzoic acid, to modify the sweetener profiles. It does not provide instructions for using multiple sweeteners.
    US patent 2007/0178123 Al (Levenson et al.) Refers to compositions that enhance the flavoring of products for the treatment of cough. Describes combinations of neotame and sucralose.
    European patent 1 869 986 (Schwarz, Rathjen) describes edible compositions said to have a sucrose flavor profile, but which comprise a combination of isomaltulose, acesulfame-K and another high intensity sweetener, such as sucralose.
    WO 2009/086049 (Catani, Liao) describes a sweetening composition that comprises a combination of sucralose and a purified stevia extract that comprises rebaudiosides and dulcosides. Within certain reasons of sucralose to stevia, the synergism of the sweetening intensity was observed. The document does not describe specific combinations of sucralose and stevia with other sweeteners.
    US patent 4,915,969 (Beyts) shows the sweetening synergy of sucralose and cyclamate within beverages.
    5/50 similar rinsing compositions,
    JP 2002-171930 (Morita et al.) Reports an excellent degree of sweetness and quality of sweetness in combinations of sucralose, stevia and acesulfame-K.
    Despite this progress in the development of innovative sweetening combinations with a more sucrose profile, there is still a need for mouthwashes, particularly toothpaste and which include compositions with optimized sweetness. It would be desirable to develop a sweetness composition that allows the amount of natural or artificial sweetener in a product supplied orally to be reduced or optimized, thereby reducing the unpleasant taste associated with specific raw materials in the product supplied orally, but which avoids adverse flavoring effects. In particular, there is a need for a sweetener composition that is capable of providing high sucrose equivalence, as well as changing the perception of the sweet flavoring of the sweetener, the residual flavor of the sweetener, the period of onset of sweetener sweetness, the period of sweetening. peak sweetness of the sweetener and / or the period of decreased sweetness of the sweetener.
    SUMMARY OF THE INVENTION
    The present invention relates to improved sweetening compositions and compositions for oral treatment, specifically those in the form of a toothpaste or mouthwash / dental, which comprises them. More specifically, the invention relates to a sweetener composition and an oral composition comprising the same, in which the sweetener composition comprises sweetener A, sweetener B and sweetener C, in which sweetener A is an artificial sweetener that has 250 to 350 sucrose equivalents, sweetener B
    6/50 is an artificial sweetener that has 500 to 600 equivalents of sucrose and sweetener C is a natural sweetener with 0.5 to 400 equivalents of sucrose. The preferred forms of sweeteners A, B and C are saccharin, sucralose and rebaudioside, respectively. Preferably, sweeteners A, B and C are in a ratio of (0.5-2) :( 0.5-2): 2. In the most preferred embodiment, the sweetener composition comprises a combination of saccharin, sucralose and rebaudioside in a ratio of about 1: 1: 2.
    The invention additionally relates to a method of improving the sweetness of a composition for oral treatment which comprises adding the sweetening composition of the invention to the composition for oral treatment.
    DETAILED DESCRIPTION OF THE INVENTION
    All percentages and ratios used later in this document are expressed in weight of the total composition, unless otherwise indicated. All percentages, ratios and contents of ingredients mentioned in this document are based on the actual quantity of said ingredient, and do not include solvents, fillers or other materials with which the ingredient may be combined in the form of a commercially available product, except where otherwise indicated. All measurements mentioned in the present invention are made at 25 ° C (i.e., room temperature), unless otherwise specified.
    For use in the present invention, the word about means +/- 10 percent. For use in the present invention, the word include and its variants are intended to be non-limiting, so that the recitation of items in a list does not imply the exclusion of other items
    7/50 that may also be useful in the materials, compositions, devices and methods of this invention.
    By composition for oral treatment in the present invention, it is understood that a product that, in the normal course of use, is not immediately swallowed for purposes of systemic administration of specific therapeutic agents, but is retained in the oral cavity for a sufficient time, or has enough contact with the tongue to experience its flavor. Applicable oral treatment compositions include particular health care products (such as cough syrups, cough drops and the like), confectionery, food and drinks (such as chewing gum, soda and the like). Preferred oral treatment compositions are not intended for nutritional foods and can be in various forms including a toothpaste or gel, subgingival gel, mouthwash, mousse, foam, mouth spray, lozenge, chewable tablet, lozenge, chewing gum or product for denture care. The composition for oral treatment can also be incorporated on tapes or films for direct application or fixation to oral surfaces. In the preferred modalities, the composition for oral treatment comprises a surfactant or other therapeutic asset directed to the oropharynx, in particular the oral cavity.
    dentifrice, for use in the present invention, includes formulations in the form of paste, gel or liquid, unless otherwise specified. The term teeth, for use in the present invention, refers to natural teeth as well as artificial teeth or dental prostheses.
    8/50
    The active ingredients and other ingredients useful in the present invention can be categorized or described in this invention for their cosmetic and / or therapeutic benefit, or for their postulated modes of action or function. However, it must be understood that the active and the other ingredients used here may, in some cases, offer more than one function or more than one cosmetic and / or therapeutic benefit, or operate through more than one mode of action. Therefore, the classifications of the present invention are made for the sake of convenience and are not intended to limit an ingredient to the particularly described functions or activities mentioned.
    Sweeteners
    References to the sweeteners of the present invention also include reference to their common salts; for example, the term saccharin includes saccharin sodium and acesulfame ”includes the potassium salt, acesulfame-K. As is commonly understood in the art, sweeteners can be characterized in terms of their equivalence to sucrose, representing the ratio between the weight of sucrose that releases a certain amount of sweetness and the weight of the sweetener needed to provide the same amount of sweetness, as determined by the panel of experts comparing the sweetness intensity of sweetener solutions to sucrose stock solutions. Since sucrose equivalence may depend on the concentration of sucrose being combined, the sucrose equivalents of the present invention are 10% sucrose equivalents. Thus, if a 0.1% solution of a sweetener delivers the same sweetness intensity as a 10% sucrose solution, the sweetener has a 10% sucrose equivalence of 100 (10 / 0.1).
    9/50
    In one aspect the present invention relates to a sweetener composition in which the sweetener composition comprises sweetener A, sweetener B and sweetener C, where sweetener A is an artificial sweetener having 250 to 350 equivalents of sucrose, sweetener B is an artificial sweetener having 500 to 600 sucrose equivalents and sweetener C is a natural sweetener having 0.5 to 400 sucrose equivalents.
    Preferably, sweeteners A, B and C are in a ratio of (0.5-2): (0.5-2): 2. In one embodiment the ratio between sweetener A and sweetener B is 0.5: 1 to 2: 1, preferably 0.8: 1 to 1.5: 1. In one embodiment, the ratio between sweetener A and sweetener C is 0.3: 1 to 0.9: 1, preferably 0.3: 1 to 0.7: 1.
    sweetener A is a high intensity sweetener selected, preferably, from the group consisting of saccharin, alitame, aspartame, neotame, cyclamate and mixtures thereof. These sweeteners are typically measured with a 10% sucrose equivalence of 250 to 350. Sweetener A is most preferably saccharin.
    sweetener B is a high intensity sweetener selected, preferably, from the group consisting of trichlorosucrose (sucralose), acesulfame, neo-hesperidin DC, thaumatin, glycyrrhizin, mogroside IV, mogroside V, 1-methyl ester of I, N- [N- [3- (3-hydroxy-4methoxyphenyl) propyl] -La-aspart] -L-phenylalanine cyclocarioside, 1-methyl ester N- [N- [3- (3-hydroxy-4methoxyphenyl) -3-methyl butyl ] -La-aspart] -L-phenylalanine, 1-methyl ester N- [N- [3- (3-methoxy-4-hydroxyphenyl) propyl] -L-aaspart] -L-phenylalanine and mixtures thereof. These sweeteners have a more intense sweetness than the sweetener in
    10/50 type A and are typically measured with a 10% sucrose equivalence of 500 to 600. Sweetener B is most preferably sucralose.
    sweetener C is a naturally derived glycoside or polyol sweetener preferably selected from the group consisting of steviolglycosides, rebaudiosides A, rebaudiosides C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, dulcoside B, rubusoside, stevia, stevia, stevia , sweetener Luo Han Guo, siamenoside, monatin and its salts (monatin SS, RR, RS, SR), curculine, monelin, mabinline, brazzein, hemandulcin, philodulcin, glyphillin, floridizine, trilobatin, baiyanoside, osladin, A polypeptide A, pter , pterocarioside B, mukurozioside, flomisoside I, periandrine I, abrusoside A and mixtures thereof. In addition, sweetener C could be selected from one or more of the following naturally derived sources, for example, polyols such as xylitol, erythritol, maltitol, mannitol and sorbitol or L-arabinose, inulin, dextrin, raffinose, trehalose, tagitose or tagitol. These sweeteners are typically measured with a 10% sucrose equivalence of 0.5 to 400. In particularly desirable embodiments of the present invention, sweetener C comprises rebaudioside A in combination with one or more of rebaudiosides B, rebaudiosides C, rebaudiosides F, rebaudiosides F, stevioside, steviolbioside or dulcoside A. In a preferred embodiment of the present invention, sweetener C comprises at least 70% rebaudioside A or xylitol. REBIANA is a trade name for a high purity source of rebaudioside A marketed by Cargill, Inc. and The Coca-Cola Company.
    11/50
    It is a crystalline diterpene glycoside, about 300x more of the present invention sweet vehicle materials than sucrose. Xylitol is a polyol produced by Cargill.
    The sweetener compositions can additionally comprise edibles to optimize the flow properties of the sweetener compositions. These edible carrier materials can comprise bulk sweetening materials, in particular crystalline sugar alcohols, which although they may impart some sweetness have a much lower sweetness intensity than the sweeteners of the present invention. In addition, a flavor enhancer, such as glucone-δlactone or a hydroxy benzoic acid can be added to the sweetener composition.
    In preferred embodiments of the present invention, the sweetener compositions of the present invention comprise, in total, from 20% to 100%, preferably from 50% to 100% of sweeteners A, B and C.
    Compositions for oral treatment
    Another aspect of the present invention relates to oral treatment compositions which comprise the sweetening composition of the invention. Compositions for oral treatment can comprise from 0.001% to 4%, preferably from 0.01% to 3% of the sweetener composition of the invention.
    It is highly desirable that products intended for the consumer for use in cleaning and caring for the oral cavity provide a feeling of freshness and cleanliness as this provides consumers with a sign of freshness and continuous cleaning. In addition to the feeling of cleanliness, consumers typically want to experience the benefit of
    12/50 therapeutic oral treatment assets, such as antitartar agent, for example, through their oral treatment regimens. Oral treatment compositions are commonly composed of a combination of components that can include vehicle materials, surfactants, flavorings, dyes, sensory elements, actives and other additives. The ability to formulate a composition for oral treatment acceptable to the consumer, however, poses challenges, since many of the components used to impart a flavoring, which provide a benefit or which are part of the basis for the composition for oral treatment add flavors and / or unwanted sensations, along with the desired benefit to which they are added. Thus, the formulation of compositions for oral treatment can be a balancing act between acceptable flavoring and acceptable benefits.
    Vehicle materials for oral treatment Vehicle materials for oral treatment, in general, represent anywhere from 25% to 95% of the composition for oral treatment, by weight. Examples of materials that can act as a carrier material include water, glycerin, sorbitol, polyethylene glycols that have a molecular weight less than 50,000, propylene glycol and other edible polyhydric alcohols, ethanol or combinations thereof. Many of these vehicle materials also act as humectants that block the total dryness of toothpaste. Of these carrier materials, examples of some that provide an unwanted taste within a mouthwash composition are propylene glycol and ethanol. The unwanted flavors commonly associated with
    13/50 these types of materials are bitter taste, burning, astringency and / or earth or dirt flavors.
    Surfactants
    Another component of a composition for oral treatment, particularly a toothpaste, can be a surfactant. Surfactants are, in general, included in a composition for oral treatment in the range of 1% to 15%. The surfactant can be anionic, non-ionic, amphoteric, zwitterionic, cationic or combinations thereof. Anionic surfactants useful to the present invention include, for example, water-soluble salts of alkyl sulfates having 8 to 20 carbon atoms in the alkyl radical and water-soluble salts of sulfonated monoglycerides of fatty acids having 8 to 20 atoms of carbon. Sodium lauryl sulfate (LSS) and sodium sulfonates of coconut monoglycerides are examples of such anionic surfactants. Other suitable anionic surfactants include sarcosinates, such as sodium lauroyl sarcosinate, taurates, sodium lauryl sulfoacetate, sodium lauroyl isethionate, sodium lauret carboxylate and sodium dodecyl benzene sulfonate. Combinations of anionic surfactants can also be employed. In different embodiments, the present compositions comprise an anionic surfactant at a content of 0.025% to 9%, from 0.05% to 5%, or from 0.1% to 1%.
    Another class of anionic surfactants useful here are alkyl phosphates. The surface active organophosphate agents have a strong affinity for the enamel surface and have a propensity to bind to the surface sufficient to desorb proteins from the film and remain fixed on the enamel surfaces. Examples
    Suitable 14/50 organophosphate compounds include mono-, di- or tri-esters represented by the general structure below, where Z x , Z 2 or Z 3 can be identical or different, at least one being an organic portion, in a modality selected from the linear or branched alkyl or alkenyl group of 1 to 22 carbon atoms, optionally substituted by one or more phosphate groups; alkyl or alkoxylated alkenyl, (poly) saccharide, polyol or polyether group.
    O
    P
    O — z 3
    Some other agents include alkyl or alkenyl phosphate esters represented by the following structure:
    o — P — o — z 2 where R 3 represents a linear or branched alkenyl or alkyl group of 6 to 22 carbon atoms, optionally substituted by one or more phosphate groups; nor, are they individually and separately, 2 to 4, and b and, individually and separately, are 0 to 20; Z 2 and Z 3 can be identical or different, each representing hydrogen, alkali metal, ammonium, protonated alkylamine or functional alkylamine
    Protonated 15/50, such as an alkanolamine or a group Ri— (OC n H2n) a (OC m H2m) b - · Examples of suitable agents include alkyl and alkyl (poly) alkoxy phosphates such as lauryl phosphate; PPG5 cetearet-10 phosphate; lauret-1 phosphate;
    lauret-3 phosphate; lauret-9 phosphate; trilauret-4 phosphate; C12-18 PEG 9 phosphate and sodium dilauret-10 phosphate. In one embodiment, the alkyl phosphate is polymeric. Examples of polymeric alkyl phosphate include those containing repeating alkoxy groups such as the polymeric moiety, in particular 3 or more ethoxy, propoxy, isopropoxy or butoxy groups.
    Other suitable surfactants are sarcosinates, isethionates and taurates, specifically their alkali metal or ammonium salts. Examples include: lauryl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleo sarcosinate or combinations thereof.
    Among these anionic surfactants, examples of some that provide an undesirable taste in a composition for oral treatment include, for example, LSS, lauroyl sarcosinate and / or fatty alcohols or acids associated with naturally occurring surfactants. The unwanted flavors commonly associated with these surfactants are soaps, chemicals and / or artificial products.
    The zwitterionic or amphoteric surfactants useful in the present invention include derivatives of aliphatic quaternary ammonium, phosphonium and sulfonium compounds, in which the aliphatic radicals can be straight or branched chain, and one of the aliphatic substituents contains 8 to 18 carbon atoms and one contains an anionic water solubilizing group, for example, carboxy, sulfonate, sulfate,
    16/50 phosphate or phosphonate. Suitable betaine-based surfactants are disclosed in US patent 5,180,577 to Polefka et al. Typical alkyl dimethyl betaines include decyl betaine or 2- (N-decyl-N, N-dimethylammonium) acetate, coconut betaine or 2- (N-coco-N, N-dimethylammonium) acetate, myristyl betaine, palmitil betaine, lauryl betaine , cetyl betaine, cetyl betaine, stearyl betaine, etc. Starchetaines are exemplified by cocoamido ethyl betaine, cocoamidopropyl betaine (CADB), and lauramido propyl betaine. Among these surfactants, examples of some that provide an undesirable taste in a composition for oral treatment include, for example, cocoamido propyl betaine and lauryl betaine. The unwanted flavors commonly associated with these types of surfactants are soaps and chemicals. These surfactants are, in general, included in a composition for oral treatment in the range of 0.5% to 5%.
    The cationic surfactants useful in the present invention include, for example, derivatives of quaternary ammonium compounds, which have a long alkyl chain containing 8 to 18 carbon atoms such as trimethyl ammonium lauryl chloride; cetyl pyridinium chloride; cetyl trimethyl ammonium bromide; cetylpyridinium fluoride or combinations thereof. Among these surfactants, examples of some that provide an undesirable taste in a composition for oral treatment include, for example, cetylpyridinium chloride or chlorhexidine. The unwanted flavors commonly associated with these surfactants are chemical and / or antiseptic.
    Nonionic surfactants that can be used in the compositions of the present invention include, for example, compounds produced by the condensation of oxide groups of
    17/50 alkylene (hydrophilic in nature) with an organic hydrophobic compound, which can be aliphatic or alkylaromatic in nature. Examples of suitable additional non-ionic surfactants include Pluronics®, which are poloxamers, condensates of polyethylene oxide of alkyl phenols, products derived from condensation of ethylene oxide with the reaction product of propylene oxide and ethylenediamine, condensates of ethylene oxide aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides and combinations of these materials.
    Flavoring
    Another component that can be part of a composition for oral treatment includes a flavoring. Flavorings are, in general, present in an amount of 0.4% to 3%, by weight of the composition for oral treatment. Examples of some flavoring and flavoring components used in oral care compositions are mint oils, wintergreen oil, clove oil, cassia, sage, parsley oil, marjoram, lemon, orange, guaetol propylene, heliotropine, 4-cis -heptenal, diacetyl, methyl-p-tert-butyl phenyl acetate, methyl salicylate, ethyl salicylate, 1-menthyl acetate, oxanone, airisone, methyl cinnamate, ethyl cinnamate, butyl cinnamate, ethyl butyrate, ethyl acetate, methyl anthranylate, isoamyl acetate, isoamyl butyrate, alyl caproate, eugenol, eucalyptol, thymol, cinnamic alcohol, octanol, octanal, decanol, decanal, phenylethyl alcohol, benzyl alcohol, α-terpinol, linalol, limonene , citral, neral, geranial, nerol geraniol, maltol, ethyl maltol, anethole, dihydroanetol, carvone, menthol, β-damascenone,
    18/50 ionone, γ-decalactone, γ-nonalactone, γ-undecalactone or combinations thereof. The most suitable flavoring ingredients are chemicals containing structural characteristics and functional groups that are less prone to redox reactions. These include derivatives of flavoring chemicals that are saturated, or that contain aromatic rings or stable ester groups. Of these flavorants, examples of some that provide an unwanted flavor include, for example, citral, geranial, eucalyptol, thymol and eugenol. The unwanted flavors commonly associated with these types of flavorings are sour, chemical, bitter, pungent and / or astringent.
    Sensory elements
    Another component that can be part of a composition for oral treatment is a sensory element. Sensory element agents such as cooling, heating and tingling agents are useful in providing signals to the consumer. Sensory elements are, in general, used in proportions of 0.001% to 0.8% of the composition for oral treatment. The most well-known sensory cooling compound is menthol, particularly 1-menthol, which is found naturally in mint oil. High levels of menthol can provide a bitter taste and is sometimes associated with unpleasant notes described as earth, camphor, mold etc.
    Among synthetic refrigerants, many are derived from or are structurally related to menthol, that is, they contain the cyclohexane portion, and are derivatized with functional groups including carboxamide, acetal, ester, ether and alcohol. Examples include compounds
    19/50 p-mentanocarboxamide as N-ethyl-p-mentan-3-carboxamide. An example of a synthetic carboxamide refrigerant that is structurally unrelated to menthol is N, 2,3-trimethyl-2-isopropyl butanamide. Additional exemplary synthetic refrigerants include alcohol derivatives such as 3-1-menthoxypropane-1,2-diol, isopulegol, pmentan-3,8-diol; menthol glycerol acetal; menthol esters such as menthol acetate, menthol acetoacetate, menthyl lactate and monomenthyl succinate.
    Additional agents that are not structurally related to menthol, but that have been reported to have a similar physiological cooling effect include alpha-keto enamine derivatives described in US Patent No. 6,592,884, including 3-methyl-2- (1 -pyrrolidinyl) -2cyclopenten-1-one (3-MPC), 5-methyl-2- (1-pyrrolidinyl) -2cyclopenten-1-one (5-MPC); 2,5-dimethyl-4- (1-pyrrolidinyl) 3 (2H) -furanone (DMPF); icyline (also known as AG-35, chemical name 1- [2-hydroxyphenyl] -4- [2-nitricphenyl] 1,2,3,6-tetrahydropyrimidine-2-one) described in Wei et al., J Pharm. Pharmacol. (1983), 35: 110-112.
    Among these sensory cooling elements, examples of some that provide an unwanted taste include, for example, menthol and menthol. Unwanted flavors commonly associated with these sensory cooling elements include burning, chemicals and / or medications.
    Some examples of sensory heating elements include ethanol; nicotinate esters, such as benzyl nicotinate; polyhydric alcohols; nonanoyl vanylyl amide; vanylyl ether of nonanoic acid; derivatives of alkyl ether vanylyl alcohol such as vanylyl ethyl ether,
    20/50 vanylyl butyl ether, vanylyl pentyl ether and vanylyl hexyl ether; alkyl ethers of isovanylyl alcohol; alkyl ethers of ethylvanylyl alcohol; derivatives of veratril alcohol; substituted benzyl alcohol derivatives; alkyl substituted benzyl alcohol ethers; propylene glycol vanillin acetal; propylene glycol ethylvaniline acetal; ginger extract; ginger oil; gingerol; zingerone or combinations thereof. The sensory heating elements are, in general, included in a composition for oral treatment at a content of 0.05% to 2%.
    Examples of some tingling sensory elements include capsaicin; homocapsaicin, jambu oleoresin, zanthoxylum peperitum, saanshool-I, saanshool II, sanshoamide, piperine, piperidine, spilantol, 4— (1-methoxymethyl) -2-phenyl-1,3-dioxolane or combinations thereof. The tingling sensory elements are, in general, included in a composition for oral treatment at a content of 0.0005% to 1%. Of these tingling sensory elements, examples of some that provide an unwanted taste within a mouthwash composition include, for example, jambu and saanshool. The unwanted flavors commonly associated with these tingling elements include a peppery, bitter and / or metallic taste.
    Sweeteners
    References to the sweeteners of the present invention also include reference to their common salts; for example, the term saccharin includes saccharin sodium and acesulfame includes the potassium salt, acesulfame-K. As is commonly understood in the art, sweeteners can be characterized in terms of their equivalence to sucrose,
    21/50 representing the ratio between the weight of sucrose that releases a certain amount of sweetness and the weight of the sweetener needed to provide the same amount of sweetness, as determined by the panel of experts comparing the sweetness intensity of sweetener solutions to the sweetener solutions. sucrose stock. Since sucrose equivalence may depend on the concentration of sucrose being combined, the sucrose equivalents of the present invention are 10% sucrose equivalents. Thus, if a 0.1% solution of a sweetener delivers the same sweetness intensity as a 10% sucrose solution, the sweetener has a 10% sucrose equivalence of 100 (10 / 0.1).
    In one aspect the present invention relates to a sweetener composition with the sweetener composition consisting of sweetener A, sweetener B and sweetener C in a ratio of (0.5-1): (1-3), where the sweetener A is an artificial sweetener having 250 to 350 equivalents of sucrose, sweetener B is an artificial sweetener having 500 to 600 equivalents of sucrose and sweetener C is a natural sweetener having 0.5 to 400 equivalents of sucrose.
    Sweetener A is a high intensity sweetener selected, preferably, from the group consisting of saccharin, alitame, aspartame, neotame, cyclamate and mixtures thereof. These sweeteners are typically measured with a 10% sucrose equivalent of 250 to 350. Sweetener A is most preferably saccharin.
    sweetener B is a high intensity sweetener selected, preferably, from the group consisting of trichlorosucrose (sucralose), acesulfame, neohesperidine DC, thaumatin, glycyrrhizin, mogroside IV, mogroside V, 1-methyl ester of I, N- [N - [3- (3-hydroxy-422/50 methoxyphenyl) propyl] -La-aspart] -L-phenylalanine cyclocarioside, 1-methyl ester N- [N- [3- (3-hydroxy-4methoxyphenyl) -3-methyl butyl] -La-aspartyl] -L-phenylalanine, 1-methyl ester N- [N- [3- (3-methoxy-4-hydroxyphenyl) propyl] -L-aaspart] -L-phenylalanine and mixtures thereof. These sweeteners have a more intense sweetness than type A sweetener and are typically measured with an equivalence of
    sucrose a 10% of 500 to 600. 0 sweetener B is with the maxim preference sucralose. 0 sweetener C is a sweetener glycoside of
    natural derivation preferably selected from the group consisting of steviolglycosides, rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, dulcoside B, rubusoside, stevia, stevioside, sweetener Luo Han Guo, sos monatine and its salts (monatine SS, RR, RS, SR), curculin, monelin, mabinline, brazzein, hemandulcin, filodulcin, glyphilin, floridizine, trilobatin, baiyanoside, osladin, polypeptide A, pterocarioside A, pterocarioside B, mukurozuro , periandrine I, abrusoside A and mixtures thereof. These sweeteners are typically measured with a 10% sucrose equivalence of 0.5 to 400. In particularly desirable embodiments of the present invention, sweetener C comprises rebaudioside A in combination with one or more of rebaudioside B, rebaudioside C, rebaudioside F, rebaudioside F, stevioside, steviolbioside or dulcoside A or the polyol xylitol. Sweetener C is most preferably rebaudioside A or xylitol. REBIANA is a trade name for a high purity source of rebaudioside A, marketed by Cargill, Inc. and The
    23/50
    Coca-Cola Company. It is a crystalline diterpenic glycoside, about 300x sweeter than sucrose. Xylitol is a naturally occurring sugar alcohol and is also supplied by Cargill.
    In addition, a flavor enhancer such as glucono-õ-lactone can be added to the sweetener composition.
    Dyes
    Additionally, the dyes can be part of a composition for oral treatment. The dyes are, in general, present in an amount of 0.001% to 0.5%, by weight of the composition for oral treatment. Examples of some dyes used in oral treatment compositions include D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 40, D&C Red No. 33 and combinations thereof. The content of the dyes can vary from 0.0001% to 0.1%. In one embodiment, the dye is in an amount of 0.001% to 0.01%, by weight of the composition for oral treatment. Of these dyes, an example of a dye that provides an unwanted taste includes, for example, unwanted D&C Red commonly associated with metals and / or chemicals.
    Assets n 33. The flavors of these dyes are
    An additional component that can be included in a mouth care composition includes mouth care assets. Assets for oral treatment are, in general, present in an amount of 0.0001% to 8%. Some examples of oral treatment assets include anti-caries agents, antimicrobial agents, anti-tartar agents, bad breath reduction agents and bleaching agents. Anti-caries agents are generally used in an amount
    Representative 24/50 include: sodium, 0.01% to 3.0% fluoride. It is common to have a fluoride compound present in dentifrices and other oral compositions in an amount sufficient to give a fluoride ion concentration in the composition of 0.0025% to 5.0% by weight to provide anti-carious efficacy. In one embodiment, the fluoride concentration is 0.005% to 2.0% by weight. A wide variety of fluoride ion yield materials can be used as sources of soluble fluoride in the present compositions and methods. Examples of materials that produce suitable fluoride ions are found in US Patent No. 3,535,421 to Briner et al. and in US patent 3,678,154 to Widder et al. The sources of ion fluoride stannous fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, indium fluoride, amine fluorides, such as Olaflur and many others. In one embodiment, anti-caries agents comprise 0.454% stannous fluoride. In another embodiment, the anti-caries agents comprise 0.243% sodium fluoride. Of these anti-caries agents, examples of some that provide an unwanted taste include, for example, stannous fluoride and potassium fluoride. The unwanted flavors commonly associated with these anti-caries agents include earth, dirt and / or metallic flavors.
    Another asset for oral treatment is an antimicrobial agent. An example of an antimicrobial agent is a quaternary ammonium compound. Those useful for the present invention include, for example, those in which one or two of the substitutes in quaternary nitrogen have a carbon chain length (typically alkyl group) of 8 to 20, typically 10 to 18 carbon atoms,
    25/50 while the remaining substitutes (typically alkyl or benzyl group) have a lower number of carbon atoms, such as 1 to 7 carbon atoms, typically methyl or ethyl groups. Typical examples of quaternary ammonium-based antibacterial agents are: dodecyl trimethyl ammonium bromide, tetradecylpyridinium chloride, domiphene bromide, N-tetradecyl-4ethylpyridinium chloride, dimethyl dodecyl (2-phenoxyethyl) ammonium chloride, benzyl dimethyl chloride stearyl ammonium, cetylpyridinium chloride, 5-amino-1,3-bis (2-ethyl hexyl) -5-methyl hexahydropyrimidine quaternized, benzalkonium chloride, benzethonium chloride and benzethonium methyl chloride. Other compounds include bis [4- (R-amino) -1-pyridinium] alkanes as disclosed in US Patent No. 4,206,215, June 3, 1980, to Bailey. Other quaternary ammonium compounds include pyridinium compounds. Examples of pyridinium quaternary ammonium compounds include cetylpyridinium halide and tetadecylpyridinium salts (i.e., chloride, bromide, fluoride and iodide). Quaternary ammonium-based microbicidal agents can be included in levels of at least 0.035%. In other modalities they are included from 0.045% to 1.0% or from 0.05% to 0.10%, by weight of the composition for oral treatment.
    The present invention may also include other antimicrobial agents including non-cationic antimicrobial agents, such as halogenated diphenyl ethers, phenolic compounds including phenol and their homologues, mono and polyalkyl and aromatic halophenols, resorcinol and its derivatives, xylitol, bisphenolic compounds and halogenated salicylanilides, esters benzoic and halogenated carbanilides. Antimicrobials also useful are enzymes, including
    26/50 endoglycosidase, papain, dextranase, mutanase and combinations thereof. Such agents are disclosed in US patent 2,946,725, July 26, 1960, to Norris et al. and in US patent 4,051,234 to Gieske et al. Examples of other antimicrobial agents include chlorhexidine, triclosan, triclosan monophosphate and flavoring oils like thymol. Triclosan and other agents of this type are presented in Parran, Jr. et al., US patent 5,015,466, and US patent 4,894,220 to Nabi et al. These agents can be present in contents of 0.01% to 1.5%, by weight, of the dentifrice composition. Among the antimicrobial agents above, examples of some that provide an unwanted taste include, for triclosan and thymol. The flavors associated with these types of antimicrobial agents include a bitter, dirty, earthy, sour and / or astringent taste.
    Another active agent for oral treatment includes anti-tartar agents. An example of an anti-tartar agent is a pyrophosphate salt as an ion source. The pyrophosphate salts useful in the present include, for example, the metal pyrophosphate salts of mono, di and tetra-alkali and combinations thereof. Disodium pyrophosphate dihydrogen (Na 2 H 2 P 2 O 7 ), sodium acid pyrophosphate, tetrasodium pyrophosphate (Na 4 P2O 7 ) and rapotassium tet pyrophosphate (K 4 P 2 O 7 ) in their unhydrated forms as well as hydrated, they are additional species. In the compositions of the present invention, the pyrophosphate salt can be present in one of three forms: predominantly dissolved, example, chlorhexidine, commonly unwanted pyrophosphate. predominantly undissolved compositions or a combination of dissolved and undissolved pyrophosphate. The amount of pyrophosphate salt useful in the production of these compositions is any effective amount
    27/50 for the control of tartar. In different modalities, the amount of pyrophosphate salt is 1.5% to 15%, 2% to 10% or 3% to 8%, by weight of the composition for oral treatment.
    An additional example of an oral treatment asset is a whitening agent for teeth whitening. Examples of bleaching agents include peroxides, perborates, percarbonates, peroxyacids, persulfates and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, sodium peroxide, zinc peroxide or combinations thereof. An example of a percarbonate is sodium percarbonate. An example of a persulfate includes oxones. The amounts shown below represent the amount of peroxide raw material, although the peroxide source may contain other ingredients in addition to the peroxide raw material. For example, the peroxide source could be a solution, a peroxide raw material and a vehicle material. In general, the present composition can contain from 0.01% to 30% of peroxide raw material. In other modalities, the peroxide raw material is 0.1% to 10% or 0.5% to 5%, by weight of the composition for oral treatment. Of these bleaching agents, examples of some that provide an undesirable taste in a composition for oral treatment include, for example, peroxide and percarbonate. Unwanted flavors commonly associated with these bleaching agents include dirty, chemical and / or sour.
    Another asset for oral treatment is a bad breath reduction agent. Examples of bad breath reducing agents include copper salts and carbonyl compounds
    28/50 as ascorbic acid [3-oxo-L-gulofurraioliolone]; cisjasmone [3-methyl-2- (2-pentenyl-2-cyclopentenone)]; 2,5dimethyl-4-hydroxy-3 (2H) -furanone; 5-ethyl-3-hydroxy-4-methyl-2 (5H) -furanone; vanillin [4-hydroxy-3-methoxy benzaldehyde]; ethyl vanillin; anisaldehyde [4-methoxy benzaldehyde]; 3,4-methylene dioxide benzaldehyde; 3,4-dimethoxy benzaldehyde; 4-benzaldehyde hydroxy; 2-methoxy benzaldehyde; benzaldehyde; cinnamaldehyde [3-phenyl-2-propenal]; hexyl cinnamaldehyde; α-methyl cinnamaldehyde '; ortho-methoxy cinnamaldehyde or combinations thereof. | Without sticking to the theory, it is believed that certain bad breath reducing agents act as traps for fiolation with thiol!
    or sulphide and formation of products with less odor impact. Of these bad breath reduction agents, an example of one that provides an undesirable taste in a composition for oral treatment includes, for example, anisaldehyde. The unwanted flavors commonly associated with these types of bad breath reducing agents include chemical, plastic, bitter, and / or sour. i
    Metallic salts
    Another potential component in a composition for oral treatment is a metal salt. Metal salts have a wide range of functions, from one antimicrobial agent to
    In a sensitivity and / or tampon modality, the metal salt comprises a zinc salt, stannous salt, potassium salt, copper salt or a combination thereof. In another embodiment, the zinc salt is selected from the group consisting of zinc fluoride, zinc chloride, zinc iodide, zinc chlorofluoride, zinc acetate, zinc hexafluorozirconate, zinc sulfate, zinc lactate , zinc tartrate, gluconate
    29/50 zinc, zinc citrate, zinc malate, zinc glycinate, zinc pyrophosphate, zinc metaphosphate, zinc oxalate, zinc phosphate, zinc carbonate and combinations thereof. In another embodiment, the zinc salt comprises zinc chloride, zinc citrate, zinc gluconate, zinc lactate, zinc oxide or combinations thereof.
    In an additional embodiment, the potassium salt is selected from the group consisting of potassium nitrate, potassium citrate, potassium oxalate, potassium bicarbonate, potassium acetate, potassium chloride and combinations thereof. In another embodiment, the potassium salt comprises potassium nitrate, potassium citrate, potassium chloride or combinations thereof.
    In an additional embodiment, the copper salt is selected from the group consisting of copper fluoride, copper chloride, copper iodide, copper chlorofluoride, copper acetate, copper hexafluorzirconate, copper sulfate, copper lactate, tartrate copper, copper gluconate, copper citrate, copper malate, copper glucinate, copper pyrophosphate, copper metaphosphate, copper oxalate, copper phosphate, copper carbonate and combinations thereof. In another embodiment, the copper salt comprises copper gluconate, copper acetate, copper glycinate or a combination thereof.
    In another embodiment, the stannous salt is selected from the group consisting of stannous fluoride, stannous chloride, stannous iodide, stannous chlorofluoride, stannous acetate, stannous hexafluorzirconate, stannous sulfate, stannous lactate, stannous tartrate, stannous glucate, bad stannous citrate glycinate
    Stannous, stannous pyrophosphate, stannous metaphosphate, stannous oxalate, stannous phosphate, stannous carbonate, stannous gluconate and combinations thereof. In another embodiment, the stannous salt comprises stannous fluoride, stannous chloride, stannous chloride, stannous fluoride, stannous lactate, stannous gluconate, stannous sulfate or a combination thereof.
    In another embodiment, the strontium salt can be selected from the group comprising: strontium chloride, strontium citrate, strontium lactate, strontium gluconate, strontium fluoride, strontium bromide, strontium nitrate, strontium oxalate, strontium carbonate, strontium iodide, strontium sulfate, strontium hydroxide and strontium acetate.
    Dentifrices containing stannous salts, particularly stannous fluoride and stannous chloride, are described in US patent 5,004,597 to Majeti et al. Other descriptions of stannous salts are found in US patent 5,578,293 issued to Prencipe et al. and in US patent 5,281,410 issued to Lukacovic et al. In addition to the stannous ion source, other ingredients needed to stabilize the stannous can be included, such as the ingredients described in Majeti et al. and Prencipe et al.
    Some examples of metal salts that provide a residual flavor include zinc chloride, zinc citrate, copper gluconate, zinc gluconate or combinations thereof. The unpleasant flavors associated with these types of metallic salts are dirty, dry, earthy, metallic, sour, bitter and astringent.
    metallic salt will be present in an amount of 0.05% to 11%, by weight of the composition for oral treatment
    31/50 in one mode. In other modalities, metal salts are present in an amount of 0.5 to 7% or 1% to 5%. In additional embodiments, stannous salts are present in an amount of 0.1 to 7% or 1% to 5% or 1.5% to 3%, by weight of the composition for oral treatment. In certain embodiments, the amount of zinc or copper salts used in the present invention can be in the range of 0.01 to 5%. In other embodiments, the amount of zinc or copper salts is 0.05 to 4% or 0.1 to 3.0%.
    Thus, in one embodiment, the present invention relates to a method for improving the taste of a composition for oral treatment, which comprises providing a composition for oral treatment comprising an alkyl phosphate, betaine surfactant, cetylpyridinium chloride, phosphate, polymer, metal salt, potassium salts, a peroxide, or a combination thereof and adding to the composition for oral treatment rebiana in an amount of 0.05% to 0.4%, by weight of the composition for oral treatment, saccharin in an amount of 0.05% to 0.4%, by weight of the composition for oral treatment, and sucralose in an amount of 0.05% to 0.4%, by weight of the composition for oral treatment. In one embodiment, the metal salt comprises a zinc salt, stannous salt, potassium salt, copper salt or a combination thereof. In another embodiment, peroxide is selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium peroxide and combinations thereof. In an additional embodiment, the potassium salt comprises potassium nitrate and is present in an amount of 0.01% to 5.0%, by weight of the composition for oral treatment. In another modality, the zinc salt
    32/50
    understands citrate in zinc and is present in an amount 0.05 % a 5.0%, by weight of the composition for treatment oral. In another modality, O peroxide in hydrogen is present in a amount in 0.001% a 5.0 % by weight composition for oral treatment. Examples Test of consumer I As purpose of Show O It is made of
    sweetener combinations on the taste-reducing effects of alkyl phosphates in a toothpaste, the following formulations were made and tested on a panel of 10 people. The panel classified the flavor attributes of the following formulations. The averages of 10 examiners for each classification were reported from brushing to 30 minutes after brushing.
    Ingredient Ia Ib Ic Id Ie If IG Ih li Carbomer 956 0.2 0.3 0.2 0.2 0.2 0.2 0.2 CMC 0.75 0.2 1.0 1.0 1.0 1.0 Color solution (1%) 0.05 0.05 0.50 0.75 0.18 0.02 0.25 0.05 0.05 Wintergreen flavor for seasoning 0.15 Mint flavorand fruit 0.55 Mint flavor 0.59 0.45 0.42 1.0 1.2 1.0 1.0 Cinnamon Flavorings 0.5 Vanylyl butyl ether 0.02 WS-23 0.02 0.05 0.02 WS-3 0.02 0.05 0.02 MGA 0.2
    33/50
    Menthol 0.52 0.55 0.56 0.15 0.58 G-180 0.01 0.03 , 015 , 004 0.01 0.01 0.03 008 0.02 Potassium sorbate , 004 008 , 004 , 004 Poloxamer 407 1.0 0.2 0.2 0.2 0.2 0.2 Polyethylene glycol 300 3.0 3.0 3.00 Polyethylene glycol 600 2.3 Propyleneglycol 10.0 Sweetener 0.46 0.5 0.45 0.4 0.58 0.4 0.4 0.4 0.4 Abrasive based on silica 22, 0 31.0 20.0 21.0 17.0 15.0 15.0 15.0 15.0 Sodium benzoate 0.004 0.004 0.004 OO°! Silica thickener 2.0 7.0 7.0 7.0 7.0 Sodium bicarbonate 1.50 9.0 Sodium carbonate 0.50 50% NaOH solution 1.74 2.20 2.0 2.0 2.0 2.0 LSS (27.9% solution) 4.0 5.0 3.0 4.0 4.0 3.0 2.0 Sodium fluoride 0.243 0.243 0.243 Sodium MFP 0.76 0.76 0.76 0.76 0.76 0.76 Glycerin,Farm, from the USA, 99.7% 9.0 11, 9 33.0 9.0 Farm sorbitol solution.from the USA 24.3 24.5 4.0 44.7 56, 9 43.0 43.0 40.0 38.0 Pyrophosphatetetrasodium,anhydrous 2.05 5.05 3.85 3.85 Pyrophosphate 6, 38
    34/50
    tetrapotassium (60% solution) AcidNa pyrophosphate 2.1 4.0 1.0 4.3 4.5 4.5 2.0 Alkyl phosphate 13.5 6.7 3.5 3.5 Cocamido propyl betaine(30% solution) 3.5 Titanium dioxide 0.5 1.0 0.25 0.3 0.3 0.2 0.2 Carnauba wax nibbles 0, 6 0.3 Xanthan gum 0, 6 0.4 0.45 0.7 0.3 0.3 0.3 0.3 Waterpurified,Farm, USA q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s.
    Rhodium sodium phosphate supplied by Rhodia
    The If formula had the following sweetener combinations:
    Sample: If-1 If-2 If-3 If-4 If-5 If-6 If-7 If-8 If-9 Saccharin 0.2 0.1 0.05 0.2 0.2 0.2 0, 1 0, 1 0, 1 Sucralosand - - - - - - - - - REBIANA - - - 0.2 0.1 0.05 0.2 0.1 0.05
    Sample: If-10 If-11 If-12 If-13 If-14 If-15 If-16 If-17 If-18 Saccharin 0.05 0.05 0, 05 0.1 0.1 0.1 0.05 0.05 0, 05 Sucralosand - - - 0.1 0.1 0.1 0.01 0.01 0.01
    35/50
    REBIANA 0.2 0, 1 0.05 0.2 0.1 0.05 0.1 0.1 0, 1 NHDC - - - - - - 0.1 0.05 0.05 Talina - - - - - - - 0.05 0.05
    Sample: If-19 If-20 If-21 If-22 If-23 If-24 If-25 If-26 If-27 If-28 Saccharin 0.4 0.2 - - - - - - - - Sucralose - 0.2 - - - - - - - 0.4 REBIANA - - - - - 0.4 - - - - NHDC - - - - - - 0.2 - - - Talina - - - - - - - - 0.2 - Acesulfame-K - - 0, 8 - - - - - - - Aspartame - - - 0.21 - - - - - - Neotame - - - - 0.5 - - - - - Magnasweet - - - - - - - 0.02 - -
    Data on samples I f -1 to f -28 are shown below:
    Sweetness ratings 0 = Without sweetness; 25 = Slightly sweet; 50 = Adequate; 75 =Slightly very sweet; 100 = Very sweet Product No. DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-1 17.5 10.0 12.5 12.5 10.0 12.5 12, 5 12.5 If-2 10.0 2.5 5.0 10.0 10.0 5.0 5.0 2.5 If-3 17.5 12.5 17.5 17.5 10, 0 7.5 7.5 7, 5 If-4 34.1 25, 0 22.7 22.7 22.7 18.2 15, 9 11.4 If-5 30.0 27.5 15, 0 15.0 15, 0 15.0 12.5 15.0
    36/50
    Sweetness ratings 0 = Without sweetness; 25 = Slightly sweet; 50 = Adequate; 75 =Slightly very sweet; 100 = Very sweet Product No. DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-6 17.5 15, 0 12.5 10.0 7.5 2.5 2.5 2.5 If-7 12.5 17.5 15.0 5.0 7.5 7.5 7.5 10, 0 If-8 16, 7 16, 7 13.9 11, 1 11, 1 8.3 8.3 8.3 If-9 15, 0 15, 0 17.5 17.5 17.5 17.5 12.5 15, 0 If-10 20, 0 12, 5 15.0 15, 0 15, 0 7.5 7.5 5.0 If-11 18.2 18.2 20.5 9.1 2.3 2.3 2.3 2.3 If-12 16, 7 11, 1 8.3 5.6 5, 6 2.8 5, 6 2.8 If-13 45, 0 45, 0 42.5 40, 0 37.5 30, 0 27.5 27, 5 If-14 32.5 30, 0 25.0 22.5 10.0 10.0 10.0 10, 0 If-15 38, 9 27.8 25.0 19, 4 16, 7 13, 9 8.3 8.3 If-16 27.3 45, 5 40.9 27.3 18.2 13, 6 13, 6 13, 6 If-17 17.5 25, 0 17.5 15.0 15.0 12, 5 10.0 10.0 If-18 25, 0 25, 0 27.8 27.8 27.8 22.2 22.2 22.2 If-19 25.0 27.5 27.5 25.0 22.5 10.0 7.5 7.5 If-20 27.5 35.0 32.5 35.0 25.0 20.0 20, 0 15, 0 If-21 20.0 20, 0 22.5 17.5 12.5 12.5 10.0 10, 0 If-22 5.0 7.5 5.0 2.5 2.5 2.5 2.5 2.5 If-23 10.0 7.5 5.0 7.5 5.0 7.5 5.0 5.0 If-24 20.0 20, 0 17.5 17.5 10.0 7.5 10.0 10.0 If-25 20.0 32, 5 27.5 30.0 30.0 22.5 20, 0 17, 5 If-26 5.0 12, 5 5.0 2.5 2.5 5.0 5.0 5.0 If-27 5.0 5.0 7.5 7.5 5.0 2.5 0.0 0.0 If-28 52.8 47.2 47.2 47.2 36, 1 27.8 25.0 25.0
    Ratings from 0 = Without bitter taste; 25 =Slightly bitter; 50 = Adequate; 75 = Moderately bitter; 100 = Very bitter bitter taste
    37/50
    Product No. During brushing After brushingto 5min 10min 15min 20min 25min 30min If-1 52.5 57.5 37.5 27.5 12.5 10.0 7.5 7.5 If-2 55.0 60.0 42.5 25, 0 17, 5 12.5 10, 0 10.0 If-3 37.5 52.5 47.5 32.5 17, 5 15.0 7.5 7.5 If-4 27.3 45.5 15.9 11.4 2.3 2.3 0.0 0.0 If-5 25.0 30.0 22.5 10.0 7.5 7.5 7.5 5.0 If-6 40.0 47.5 30.0 17.5 15, 0 5.0 7.5 5.0 If-7 32.5 50.0 42.5 20, 0 12, 5 7.5 2.5 2.5 If-8 30.6 30, 6 19.4 8.3 2.8 2.8 5.6 8.3 If-9 42.5 47.5 27.5 15, 0 12.5 5.0 5.0 5.6 If-10 30.0 57.5 37.5 20.0 15, 0 7.5 2.5 2.5 If-11 45.5 52.3 31.8 20, 5 9.1 4.5 2.3 2.3 If-12 41.7 47.2 38.9 22.2 11, 1 11.1 11, 1 11.1 If-13 7.5 20.0 10.0 10.0 10, 0 10.0 7.5 7.5 If-14 30.0 27.5 17.5 12.5 12.5 10.0 7.5 10.0 If-15 19.4 44.4 25.0 16, 7 5.6 5, 6 5, 6 5, 6 If-16 40.9 47.7 29.5 20, 5 11.4 6, 8 4.5 4.5 If-17 40.0 50.0 35.0 25, 0 20, 0 10.0 5.0 5.0 If-18 38.9 50.0 27.8 16, 7 13, 9 11.1 8.3 8.3 If-19 35.0 37.5 25.0 15, 0 7.5 5.0 5.0 5.0 If-20 25.0 27.5 22.5 17.5 10.0 7.5 7.5 7.5 If-21 42.5 52.5 25.0 15, 0 10, 0 10.0 10.0 7.5 If-22 57.5 60.0 50.0 25, 0 17.5 12.5 10, 0 10.0 If-23 40.0 50.0 35.0 22, 5 15.0 7.5 5.0 2.5 If-24 52.5 70.0 47.5 27.5 15.0 7.5 5.0 5.0 If-25 50.0 67.5 40.0 20, 0 17, 5 10.0 10.0 10.0 If-26 70.0 75.0 55.0 32, 5 27.5 17.5 10.0 10.0 If-27 52.5 60.0 42.5 25, 0 15, 0 5.0 5.0 5.0 If-28 27.8 36.1 33.3 16, 7 11, 1 11.1 8.3 2.8
    38/50
    Freshness Ratings 0 = Very cool; 25 = Slightly without freshness; 50 = Neutral;75 = Slightly Cool; 100 = A lotFresh Product No. DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-1 72.5 75, 0 75.0 70, 0 62.5 55.0 52.8 52.5 If-2 67.5 72.5 67.5 62.5 57.5 50.0 47.5 45.0 If-3 72.5 75, 0 75, 0 75.0 70.0 57.5 52.5 50.0 If-4 72.7 86, 4 86.4 75.0 68.2 59, 1 50.0 47.7 If-5 72.5 75, 0 72.5 65, 0 57.5 52.5 50.0 47, 5 If-6 75, 0 80, 0 80.0 75.0 60.0 52.5 52.5 47.5 If-7 75.0 85, 0 75.0 65.0 60.0 50.0 45.0 47.5 If-8 77.8 83.3 80, 6 72.2 69.4 55, 6 50.0 44, 4 If-9 75.0 85.0 85.0 80.0 75.0 72.5 60.0 58.3 If-10 77.5 85, 0 80.0 75.0 67.5 57.5 50.0 50.0 If-11 75.0 79, 5 75, 0 63, 6 63, 6 54.5 47.7 45.5 If-12 66.7 77.8 69, 4 61.1 58.3 44.4 41.7 41.7 If-13 87.5 92.5 90, 0 87.5 82.5 70.0 65.0 55.0 If-14 70.0 87.5 82.5 72.5 62.5 60.0 52.5 50.0 If-15 80.6 94.4 91.7 86, 1 77.8 63, 9 55, 6 55.6 If-16 65.9 81.8 77.3 70.5 63, 6 61.4 54.5 52.3 If-17 67.5 72.5 70, 0 65, 0 60, 0 60, 0 55.0 55.0 If-18 72.2 77, 8 86, 1 77.8 69.4 61.1 58.3 58.3 If-19 70.0 87.5 82.5 75, 0 62.5 57.5 52.5 52.8 If-20 77.5 87.5 77, 5 70.0 65.0 60.0 52.5 47.5 If-21 67.5 80.0 77, 5 67.5 67.5 62.5 57.5 55.0 If-22 52.5 65.0 60.0 57.5 50.0 47.5 47.5 45.0 If-23 67.5 77.5 80, 0 72.5 60.0 55.0 50.0 47, 5 If-24 57.5 72.5 72.5 62.5 60.0 60.0 50.0 50.0 If-25 65.0 80.0 72.5 75.0 67.5 65.0 55.0 50.0 If-26 47.5 52.5 55.0 52.5 50.0 50.0 45.0 50.0 If-27 52.5 65.0 65, 0 60.0 50.0 47.5 42.5 42.5
    39/50
    Freshness Ratings 0 = Very cool; 25 = Slightly without freshness; 50 = Neutral;75 = Slightly Cool; 100 = A lotFresh Product No. DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-28 80.6 83.3 86.1 80, 6 77.8 69, 4 61.1 55, 6
    Cleanliness ratings 0 = Feeling very dirty; 25 = Feeling slightly dirty; 50 = Neutral; 75 = Feeling slightly clean; 100 = Very clean feeling Product No. DuringThebrushingO Immediately after rinsing 5min 10min 15min 20min 25min 30min If-1 70.0 82.5 82.5 75, 0 67.5 57.5 55.0 52.5 If-2 72.5 77.5 80.0 72.5 70.0 62.5 57.5 52.5 If-3 65.0 82.5 85.0 85, 0 80.0 67.5 65.0 60.0 If-4 75.0 79.5 79, 5 72.7 70.5 65, 9 63, 6 63, 6 If-5 70.0 82.5 75.0 70.0 67.5 62.5 60.0 57.5 If-6 72.5 80.0 82.5 77.5 72.5 70.0 60.0 57.5 If-7 75.0 85.0 80.0 77.5 72.5 62.5 57.5 57.5 If-8 80.6 91.7 80, 6 75.0 75, 0 66.7 55.6 52.8 If-9 77.5 87.5 85.0 82.5 77.5 77.5 70.0 70.0 If-10 77.5 85.0 82.5 75, 0 72.5 70.0 60.0 60.0 If-11 65, 9 79.5 75.0 70.5 68.2 65, 9 61.4 59, 1 If-12 75, 0 86.1 86, 1 77, 8 72.2 63, 9 61.1 62.5 If-13 87.5 95.0 92.5 92.5 85.0 75, 0 70.0 67.5 If-14 80.0 95.0 85.0 75.0 67.5 60.0 60.0 57.5 If-15 88, 9 97.2 88, 9 86, 1 83.3 69, 4 69.4 66.7 If-16 72.7 75.0 79, 5 79.5 68.2 61.4 59, 1 61.4 If-17 67.5 80.0 75, 0 67.5 67.5 57.5 57.5 55.0 If-18 75.0 84.4 78.1 78.1 68.8 68.8 62.5 59, 4 If-19 75.0 85.0 80.0 75.0 70.0 65.0 60.0 60.0
    40/50
    Cleanliness ratings 0 = Feeling very dirty; 25 = Feeling slightly dirty; 50 = Neutral; 75 = Feeling slightly clean; 100 = Very clean feeling Product N 0 DuringThebrushingO Immediately after rinsing 5min 10min 15min 20min 25min 30min If-20 75.0 85, 0 80.0 72.5 65.0 57.5 55.0 52.5 If-21 77.5 85.0 82.5 75, 0 70.0 65.0 62.5 57.5 If-22 60.0 65.0 65.0 62.5 57.5 57.5 55.0 55.0 If-23 77.5 80.0 77.5 72.5 65.0 65.0 62.5 61.1 If-24 72.5 75, 0 80.0 72.5 65, 0 60.0 57.5 57.5 If-25 62.5 72.5 70.0 72.5 67.5 67.5 62.5 60.0 If-26 55.0 57.5 65.0 62.5 62.5 65.0 62.5 62.5 If-27 65.0 65, 0 60.0 60.0 55.0 50.0 50.0 50.0 If-28 77.8 80, 6 80, 6 77.8 75.0 72.2 63, 9 58.3
    Flavor Ratings 0 = Very negative; 25 = Slightly negative; 50 = Neutral; 75 = Slightly positive; 100 = Very positive Product No. DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-1 32.5 30.0 37.5 40.0 45.0 45.0 42.5 42.5 If-2 25.0 25.0 30.0 32.5 37.5 42.5 40.0 40.0 If-3 35.0 27.5 33.3 40.0 42.5 45.0 45.0 47.5 If-4 50.0 47.7 52.3 54.5 52.3 52.3 52.5 52.5 If-5 47.5 40, 0 42.5 42.5 4 0.0 37.5 45, 0 45.0 If-6 42.5 40.0 47.5 47.5 47.5 47.5 47.5 47.5 If-7 37.5 32.5 37.5 45.0 47.5 47.5 50.0 50.0 If-8 50.0 41.7 47.2 47.2 50.0 47.2 47.2 47.2 If-9 30.0 32.5 37.5 42.5 47.5 50.0 47.5 47.5 If-10 37.5 27.5 35.0 40.0 42.5 42.5 45.0 42.5 If-11 27.3 22.7 40.9 38.6 40.9 40.9 40.9 43.2
    41/50
    Flavor Ratings 0 = Very negative; 25 = Slightly negative; 50 = Neutral; 75 = Slightly positive; 100 = Very positive Product N 0 DuringThebrushingO After brushingO 5min 10min 15min 20min 25min 30min If-12 33.3 22.2 30.6 36, 1 44.4 44.4 41.7 44.4 If-13 67.5 62.5 67.5 67.5 60.0 55.0 50.0 50.0 If-14 38.9 41.7 41.7 41.7 44.4 41.7 44.4 44.4 If-15 55, 6 44.4 50.0 50.0 50.0 52.8 47.2 47.2 If-16 38.6 36, 4 40.9 50.0 52.3 56.8 52.3 50.0 If-17 30.0 25.0 32.5 32.5 40.0 47.5 47.5 47.5 If-18 41.7 36, 1 41.7 47.2 50.0 47.2 50.0 47.2 If-19 45.0 40.0 40.0 45.0 45.0 42.5 42.5 45.0 If-20 47.5 50.0 50.0 45.0 45.0 45, 0 42.5 42.5 If-21 37.5 37.5 42.5 50, 0 52.5 45.0 40.0 45.0 If-22 7.5 10.0 20.0 27.5 37.5 40.0 42.5 42.5 If-23 20.0 15.0 22.5 30.0 30.0 37.5 37.5 37.5 If-24 17.5 20.0 32.5 35, 0 42.5 47.5 47.5 47.5 If-25 25.0 22.5 38.9 47.5 47.5 47.5 45, 0 42.5 If-26 5.0 2.5 12.5 20, 0 25.0 25.0 30.0 35, 0 If-27 12.5 7.5 12.5 20.0 30.0 32.5 37.5 35.0 If-28 44.4 44, 4 52.8 55, 6 61.1 55, 6 55, 6 55, 6
    The data showed that product no. 13 (saccharin: sucralose: rebiana in a 1: 1: 2 ratio) outperformed all other combinations, including saccharin: sucralose (product 20) combinations and better than saccharin alone (products of 1 to 3, and 19).
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    Example Product II - Metal salt containing toothpaste
    The toothpastes shown below are produced using conventional methods; the proportions are in% by weight.
    Ingredient IIA IIB IIC IID IIE Calcium carbonate 40.00 Binders 1.00 1.8 1.00 1.00 0.20 Thickeners 2.00 1, 00 1.25 0.4 0.8 Color solution (1%) 0.05 0.05 0.175 Dibasic calcium phosphate dihydrate 35.00 Flavoring zante 1 1.00 1.00 1.00 1.00 1, 00 Refreshing agents 0.03 0.24 0.20 0.50 0.58 EVB 0.01 0.01 0.01 0.01 0.01 Glycerin Farm, USA 16.489 15.00 Poloxamer 407, National Formula 0.20 Monosodium orthophosphate Potassium nitrate 5.00 Saccharin Sodium Farm, USA 0.47 0.25 0.30 0.300 0.58 Abrasive based on silica 24.00 12, 50 17.00 27.9% sodium lauryl sulfate solution 7.50 7.00 5.50 7.00 4.00 50% NaOH solution 1.00 Sodium monofluoro phosphate 0.76 0.76 0.76 0.76 Sodium fluoride 0.32 Sodium gluconate 1.00
    43/50
    Stannous chloride dihydrate 1, 00 Zinc Citrate 0.50 Tribasic sodium phosphate 3.20 Humectant 10.50 33.00 12, 00 14.00 57.00 Tetrasodium pyrophosphate, anhydrous 0.50 0.50 3.85 Sodium pyrophosphate 1.00 Titanium dioxide 0.50 0.50 0.25 Purified Water, Farm, USA q.s. q.s. q.s. q.s. q.s.
    Ingredient IIF IIG IIH II IIK Calcium carbonate 40.00 Binders 1.00 1.8 1, 00 1.00 0.20 Thickeners 0.5 1.00 1.25 0.4 0, 8 Color solution (1%) 0.05 0.05 0.175 Dibasic calcium phosphate dihydrate 35.00 Flavoring 1 1.5 1.0 0, 8 1.00 0, 8 Refreshing agents 0.5 0.2 0.08 Glycerin Farm, USA 16, 4 89 15.00 0.10 Potassium nitrate 5.00 Sweetener combinations 0.47 0.25 0.30 0.300 0.58 Abrasive based on silica 24.00 12.50 17, 00 27.9% sodium lauryl sulfate solution 7.50 7.00 5, 50 7.00 4.00 50% NaOH solution 1.00 Monofluoro phosphate 0.76 0.76 0.76 0.76
    44/50
    sodium Sodium fluoride 0.32 Sodium gluconate 1, 00 Stannous chloride dihydrate 1.00 Zinc Citrate 0.50 Tribasic sodium phosphate 3.20 Humectant 12.00 33.00 12.00 14.00 57.00 Tetrasodium pyrophosphate, anhydrous 0.50 0.50 3.85 Sodium pyrophosphate 1.00 Titanium dioxide 0.50 0.50 0.25 Purified Water, Farm, USA q.s. q.s. q.s. q.s. q.s.
    The flavoring comprises about 31.3% menthol providing approximately 500 ppm menthol.
    Sample product III - 5 mouthwash compositions
    Mouthwash compositions are prepared using conventional methods and are shown below with weight percent components of the components.
    Ingredient IIIA IIIB IIIC Ethanol, Farm, US 190, standard alcohol content 15,000 15,000 15,000 Glycerin 7,500 7,500 7,500 Polysorbate 80, FormulaNational 0.120 0.120 0. 120 Flavoring 0.160 0. 160 0. 160 Sweetener combinations 0.1 0.1 0.060 Color solution 0.040 0.040 0.040
    45/50
    Cetylpyridinium chloride 0.045 0.045 0.045 Benzoic acid 0.005 0.005 005 Sodium benzoate 0.054 0.054 0.054 Water q. s. q. s . q. s .
    Example IV Product - Peroxide Mouthwash Compositions
    The peroxide-containing mouthwash compositions are shown below with amounts of the components in% by weight. These compositions are produced using conventional methods. They provide a pleasant high-impact mint flavor during use and remarkable long-lasting fresh breath.
    Ingredient VAT IVB IVC IVD IVE IVF 35% H2O2 solution 4.286 4.286 4.286 2, 143 4.286 4.286 Refrigerant 0.075 0.02 0.04 0.04 0.03 0.04 Flavoring 0.145 0.135 0.135 0.15 0.135 0.135 Calcium chloride 0.0250.025 0.02 0.025 0.025 Poloxamer 407 0.75 0.75 0.750 0.10 0.10 0.10 Glycerin 11.00 11.00 11.00 20.00 20.00 20.00 Propylene glycol 3.00 3.00 4.00 4.00 4.00 Sweetener combinations 0.08 - 0.068 0.06 0.08 0, 06 Polyphosphate 1.00 Phytic acid 2.00 Cetylpyridinium chloride 0.074 0.10 0.10 Sodium citrate 0.21 0.21
    46/50
    2 2 Citric acid 0.052 0.052 0.052 Alcohol, Farm, dosUSA 5.00 Purified water,Farm, USA q.s. q.s. q.s. q.s. q.s. q.s.
    Example V Product - Tartar control dentifrice compositions
    The toothpastes shown below are produced 5 using conventional methods; the proportions are in% by weight.
    Ingredient GO VB you VD VE Calcium peroxide FCC 0.10 Thickener 5.0 2.5 4.5 0.80 5.0 Binder 0.60 0.75 0.40 0.45 0.70 Polymer 0.20 Color solution (1%) 0.05 0.05 0.50 0.75 0.175 Flavoring 0.15 Refrigerant 0.02 0.05 0.02 Glycerin, Farm, USA, 99.7% 9.00 11, 85 33, 1 64 9.00 Poloxamer 407, National Formula 1.00 0.20 Tetrapotassium pyrophosphate (60% solution) 6, 38 Propylene Glycol, Farm, USA, Crest 10.00 Sweetener combinations 0.46 0.50 0.45 0.40 0.58 Sodium pyrophosphate 2.10 4.00 1, 00 Abrasive based on silica 22.00 31, 00 20.00 21.00 17.00
    47/50
    Silica thickener 2.00 Baking soda, Farm, USA 1.50 9.00 Sodium carbonate, anhydrous, National Formula 0.50 50% sodium hydroxide solution 1.74 2.20 27.9% sodium lauryl sulfate solution 4.00 5.00 3.00 4.00 4.00 Sodium monofluoro phosphate 0.76 0.76 0.76 0.76 0.76 Sorbitol solution, Farm, USA 24.28 24.54 3.985 GRANDFATHERgrandfatherod 56.885 Tetrasodium pyrophosphate, anhydrous 2.05 5.045 3.85 3.85 Titanium dioxide 0.50 1.00 0.25 Titanium dioxide / Carnauba wax nuggets 0.60 0.30 Purified Water, Farm, USA q. s . q. s . q. s . q. s . q. s.
    Example - Consumer test # 2
    The data in the Table below was from a panel of 146 people where the products were delivered in a toothpaste as produced in Example V. Seven products were selected at random and evaluated by the examiners in a monadic sequential manner over the course of a week. Respondents brushed up to twice a day (once in the morning and once in the afternoon) and then completed a self-administered computerized questionnaire. Approximately 1.0 gram of the product was used for brushing. The toothpaste (d) contained the same sweetener ratio as the product of consumer test No. 1.
    Total base size: 146 (a) (b) (c) (d)
    48/50
    Saccharin content 0.4% - 0.2% 0.1% Sucralose content - - - 0.2% REBIANA content - 0.4% 0.2% 0.2% Ratings (scale from 0 to 100, where0 = Poor, 100 = Excellent) (The) (B) (ç) (d) Overall rating 69b 62 71b 78abc Mint flavor during brushing 64b 54 67b 74ab Flavoring intensity during brushing 61b 51 62b 7 2abc Intensity of sweetness during brushing 62b 50 64b 7 2abc Cooling amount 69 64 72b 74b You can feel the product working 67 62 69b 74ab Product texture 71 68 72 78ab Product foam / bubbles 64 60 70b 73ab It's new and different 55 52 57 63ab It's a good value 60 54 61b 68abc It is a quality product 66b 58 66b 7 4abc Prevents cavities 66 61 67b 70b Prevents tartar 64 61 64 68b Strengthens enamel 62 58 64b 67b Prevents blemishes 64 60 64 69b Teeth look whiter 62 57 62 65b Removes surface stains 65 59 64 68b Feels wet mouth 62 59 65 69ab Completely cleans teeth 70 64 70 74b
    49/50
    Leaves your mouth feeling clean 72 67 73b 7 6b Keeps your mouth healthy 68 63 68 72b Easy to rinse 71 65 73b 75b No film / residue remaining on teeth 70 67 72 77ab
    Dentifrice (d) was statistically better than all other dentifrices in the test - providing greater preference in the total classification, mint flavor, flavoring intensity, sweetness impression and in value and quality.
    The dimensions and values presented in the present invention should not be understood as being strictly limited to the exact numerical values mentioned. Instead, unless otherwise specified, each of these dimensions is intended to mean both the mentioned value and a range of functionally equivalent values around that value. For example, a dimension shown as 40 mm is intended to mean about 40 mm.
    Each of the documents cited in the present invention, including any cross-reference, related patent or patent application, is hereby incorporated in its entirety, by way of reference, unless expressly excluded or otherwise limited. The mention of any document is not an admission that it is prior art in relation to any invention presented or claimed in this document, or that it, alone or in any combination with any other reference or references, teaches, suggest or present any invention like that. In addition, if
    50/50 there is a conflict between any meaning or definition of a term mentioned in this document and any meaning or definition of the same term in a document incorporated by reference, the meaning or definition attributed to that term in this document will take precedence.
    Although particular embodiments of the present invention have been illustrated and described, it should be apparent to those skilled in the art that various other changes and modifications can be made without departing from the character and scope of the invention. Therefore, it is intended to cover in the appended claims all such changes and modifications that fall within the scope of the present invention.
    1/2
    权利要求:
    Claims (2)
    [1]
    1. Sweetener composition, characterized by the fact that it consists of a combination of saccharin, sucralose and rebaudioside in a ratio of about 1: 1: 2.
    5 2. Oral composition, characterized by the fact that it comprises:
    a) the sweetener composition as defined in claim 1, preferably from 0.01% to 1% of the sweetener composition as defined in claim 1; and
    B) one or more vehicle materials acceptable for oral use.
    3. Oral composition according to claim 2, characterized by the fact that it comprises an alkyl phosphate or sodium sulfate surfactant
    15 alkyl.
    4. Oral composition, according to claim 2 or 3, characterized by the fact that it comprises an asset for oral treatment selected from anti-caries agents, antimicrobial agents, anti-tartar agents,
    20 bad breath reduction agents, bleaching agents and mixtures thereof.
    5. Oral composition according to claim 2, 3 or 4, characterized by the fact that it comprises a metallic salt selected from salts of
    25 zinc, stannous salts, potassium salts, copper salts, strontium salts and mixtures thereof, preferably selected from zinc salts, stannous salts, copper salts and mixtures thereof.
    6. Oral composition, according to
    Claim 2, characterized by the fact that it comprises an amino acid, preferably an amino acid selected from the
    Petition 870180058633, of 07/06/2018, p. 5/11
    [2]
    2/2
    group that consisting of arginine , lysine, ornithine, citrullene and mixtures thereof. 7. Composition oral, in according to claim 2, characterized by fact that you understand an agent of bleach. 8. Composition oral, in according to claim 2, characterized by fact that you understand
    a sensory element agent selected from cooling agents, heating agents, agents
    10 tingling and mixtures thereof.
    Petition 870180058633, of 07/06/2018, p. 6/11
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    同族专利:
    公开号 | 公开日
    WO2012044785A3|2013-05-02|
    AU2011308820B2|2014-09-25|
    CA2813343C|2015-06-16|
    PL2621466T3|2018-11-30|
    CN103140214A|2013-06-05|
    AU2011308820A1|2013-04-18|
    US20120082630A1|2012-04-05|
    CN103140214B|2015-09-23|
    WO2012044785A2|2012-04-05|
    MX2013003644A|2013-05-22|
    EP2621466A2|2013-08-07|
    CA2813343A1|2012-04-05|
    BR112013006643A2|2017-11-14|
    MX345950B|2017-02-27|
    US8691190B2|2014-04-08|
    EP2621466B1|2018-04-04|
    ES2673730T3|2018-06-25|
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    法律状态:
    2018-04-10| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2018-08-07| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2018-10-16| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/09/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    2021-08-10| B21F| Lapse acc. art. 78, item iv - on non-payment of the annual fees in time|Free format text: REFERENTE A 10A ANUIDADE. |
    2021-11-30| B24J| Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)|Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
    优先权:
    申请号 | 申请日 | 专利标题
    US38875310P| true| 2010-10-01|2010-10-01|
    PCT/US2011/053912|WO2012044785A2|2010-10-01|2011-09-29|Oral care compositions with improved sweetness|
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