material removal device.

专利摘要:
MATERIAL REMOVAL DEVICE. The present invention relates to a catheter having a tubular body and a rotating axis disposed within a lumen of the tubular body. A cutting element is coupled to the rotating axis, the cutting element having a cutting edge, the cutting element and the rotating axis can be moved longitudinally within the tubular body between a stored position in which the cutting element is positioned distally from a lateral opening and a cutting position in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the lateral opening. The cutting element is configured to extend through the side opening and to cut material from a vessel wall at a treatment site as the catheter is pulled proximally through the treatment site. The catheter can optionally have a rotating distal tip with an abrasive surface. The catheter includes a collection chamber positioned proximal to the cutting passage.
公开号:BR112012031907A2
申请号:R112012031907-8
申请日:2011-06-14
公开日:2020-08-04
发明作者:John Moberg
申请人:Covidien Lp；
IPC主号:

专利说明:

: Invention Patent Descriptive Report for "MATERIAL REMOVAL DEVICE". - This patent application claims the benefit of US Provisional Patent Application No. 61 / 354,487, filed on June 14, 2010, entitled "Material Removal Device and Method of Use", the content of which is incorporated herein by reference .
FIELD OF THE INVENTION The present invention relates to catheters used to remove and collect material from a treatment site in a body lumen. More particularly, this invention relates to catheters capable of transporting a totally occlused treatment site in a vessel to allow it to. the catheter effectively treats the vessel at the treatment site.
BACKGROUND OF THE INVENTION | Atherosclerosis is a progressive disease of the vascular system through which an atheroma is deposited on the inner walls of blood vessels. Atherosclerosis is a complex, progressive and degenerative condition resulting from the formation of cholesterol and other obstructive materials known as plaque, in the artery walls. The accumulation of plaques narrows the interior or the lumen of the arteries, thereby reducing blood flow.
Plaque occurs in the arteries in several different ways and can be located in numerous different anatomies throughout the arterial system. Plaque varies in composition, with portions that are rigid and fragile, referred to as calcified plaque, and other portions that are adipose and fibrous.
As time passes, atheroma deposits can become large enough to reduce or occlude the blood flow that passes through the vases, leading to symptoms of low blood flow, such as pain in the legs (when walking or at rest) ), skin ulcers, angina (at rest or during exercise), and other symptoms. To treat this disease, improving or resolving these symptoms is desirable to restore or improve the blood flow that passes through the vessel.
Various means are used to restore or improve the flow
. blood that passes through atheromatous vessels. Atomic deposits can be displaced by expanding the vessel diametrically using inflatable balloons, expansion stents and other methods. Deposits can be sprayed using lasers and other methods. Atherectomy catheters can be used to remove atheroma deposits from the blood vessel and can present an ideal solution when atheromatous waste removed from the vessel is captured and removed from the body. Various types of devices with atherectomy catheter have been proposed, which include catheters with rotating protrusions, lasers for photo-dissolving tissue, and catheters with a cutter balloon. And all of them present challenges, however, such as the transposition of small and sinuous arteries to reach the target zone or areas of occluded plaque. This can be especially difficult if the treatment site has been completely occluded by the À plate. Another challenge is the inability to safely and efficiently handle and remove the plaque, which is removed from the vessel walls during the atherectomy procedure. Some devices are not designed to handle the fragments released by the plate and allow these fragments to migrate through the circulation. This can cause several problems as the waste from the released plaque can be thrombus-genic and can end up causing occlusions downstream. Other catheter models reduce this problem by capturing the removed plaque in a collection or storage chamber in such a way that it can be removed from the vessel.
A recent atherectomy catheter, the SilverHawkº rotating and articulated atherectomy catheter (sold by ev3, Inc.) was designed to address these problems. The SilverHawkº catheter (the characteristics of which are exemplified in US Patent Numbers 7,771,444; 7,713,279; and 7,708,749 which are incorporated here in their entirety by reference) uses a single rotating blade, a lateral cutting passage through which blade can be extended, and an articulated nozzle model that can be controlled to induce the catheter to assume a straight or angular position. During the cutting procedure, the catheter is in the
- angular position and, therefore, the lateral cutting passage and the cutting blade can be pushed against the vessel wall. The SilverHawkº catheter is moved distally through the lesion during the cutting procedure. The SilverHawk "catheter includes a collection chamber located in a distal nozzle portion of the cutting passage catheter. The cutting blade and cutting passage are configured to direct the cut material from the vessel wall through the cutting passage. and inside the collection chamber. Although the SilverHawkº catheter represents a significant advance in relation to prior art devices, some challenges still exist for atherectomy catheters, for example, if the treatment site is a CTO (occlusion) total and chronic) it may not be possible to transpose the lesion with the catheter. Sometimes CTOs are composed of a 'hard and calcified material, which is difficult or even impossible to transpose with a standard guidewire or a catheter of If the CTO cannot be transposed with the atherectomy catheter to allow it to be placed in the proper treatment position, the catheter cannot be used to remove the mater ial of the treatment site and other alternative treatments should be used.
In addition, catheters that remove material, such as the SilverHawkº catheter, may include a collection chamber positioned distally in the cutting passage. This requires that the length of the distal catheter of the cutting passage be long enough to accommodate the collection chamber. Which causes some conflicting model choices.
On the other hand, it is desirable that the collection chamber has a capacity large enough to accommodate a reasonable amount of cut material before the chamber is filled, and that the catheter is removed. On the other hand, the increased length of the distal catheter in the cutting passage required to accommodate a collection chamber large enough is disadvantageous in certain applications. For example, if the treatment site or the lesion is located in a vessel with a particularly sinuous anatomy or small size, there may not be enough space
; accessible to the vessel distal to the lesion to accommodate the distal length of the distal cut-through catheter. This distal space accessible to the site | of treatment is sometimes referred to as the "landing zone". For the catheter to be used effectively, the anatomy of the vessel must be such as to allow the catheter to be advanced far enough to position the cut-off passage within the treatment site and the distal portion of the catheter, which houses the collection chamber in the landing zone. Thus, atherectomy catheters can be difficult to use in vessels with short landing zones. In addition, during the cutting act, the atherectomy catheter can be pushed distally by the operator from the proximal end of the catheter through the cutting blade treatment site that extends through the cutting passage. It is possible during this impulse movement that the catheter encounters resistance due to the size of the vessel or the sinuous anatomy of the vessel. This resistance can make it more difficult for the operator to control the catheter during use. A pulling motion can also compress the catheter shaft when resistance is encountered, increasing the possibility that the shaft may bend. If the resistance encountered with a traction movement is abruptly released, the catheter may jump in the distal direction, possibly causing damage to the vessel, such as perforation or dissection. When a catheter is pulled proximally through a vessel, the body of the catheter is more in tension than compression. With the existence of tension, the tendency is to have less stored energy, thus, a sudden release of the resistance found with the traction movement results in a lower possibility of the jumping catheter.
SUMMARY OF THE INVENTION The present invention provides an enhanced atherectomy catheter that has characteristics that overcome the problems found in prior art devices. In one embodiment, the atherectomy catheter has a rotating distal tip with an abrasive surface that allows the catheter to cut through and along a CTO. In another way,
. de, the atherectomy catheter has the cutting passage positioned on a side wall of the catheter and the cutting blade configured to extend À: through the cutting passage and to cut the material from a vessel wall at a location of treatment as the catheter is pulled proximally through the treatment site. In this mode, the catheter can optionally have a rotating distal tip with an abrasive surface. The catheter includes a collection chamber positioned proximal to the cutting passage. The catheter may include means for directing the cut material from the treatment site within the collection chamber.
The catheters of the present invention can also be optionally configured to prevent the drive shaft from blocking or interfering with others. another mode in the cutting passage. In one embodiment, the catheter is equipped with a cutting element that has two cutting structures and two cutting positions.
In one embodiment, the invention is a catheter for removing material from within a vascular lumen. The catheter comprises a tubular body that has proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body. A rotating axis is disposed within the barrel of the tubular body. A cutting element is coupled to the rotating axis, the cutting element having a cutting edge, the cutting element and the rotating axis can be moved longitudinally into the tubular body between a stored position in which the cutting element is positioned distally in relation to the lateral opening and a short position in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the lateral opening. The catheter also comprises a cutting element exposure member, the cutting element exposure member, which can be moved longitudinally into the tubular body between a distal position and a proximal position, the exposure member of the cutting element. cutting element being configured in such a way that the movement of the cutting element display member from the distal position to the proximal position when the cutting element
"is in the cutting position, results in movement of the cutting element from the cutting position to an extended position in which the cutting edge portion is extended through the side opening beyond an outside diameter of the tubular body A material collection chamber is positioned within the tubular body at a location proximal to the lateral opening.
This embodiment of the invention, as well as any of the other embodiments described here, may also comprise additional features, which include a swivel tip connected to the distal end of the tubular body and a set of connectors for selectively coupling and uncoupling the swivel tip from the rotating axis. The connector set may comprise first and second portions, the first portion comprising the portion of the cutting element which is shaped to mechanically connect with the second portion comprising the! rotating tip portion. This modality can additionally comprise a lumen of guide wire that extends through the rotating axis, through the cutting element and through the rotating tip in such a way that the catheter is configured as a cover for the catheter with wire. The rotating tip may comprise an abrasive surface. The catheter may also comprise a cable attached to a proximal portion of the tubular body, the cable including a power source, a motor coupled to the rotary axis, and first and second control members, the first control member being attached to the rotary axis, the second control member being attached to the cutting element display member, the first control member being configured to move the cutting element between the stored position and the cutting position, the second control member being configured to move the exposure member of the cutting element between the distal position and the proximal position. The exposure member of the cutting element may comprise a traction wire that has distal and proximal ends and an arc modeled in a bushing connected at the distal end of the traction wire, the proximal end of the traction wire being connected to the second member of control. In addition, the cutting element display member can be selectively moved for
, showing the extent by which the cutting edge is extended through the side opening.
! In this modality, as well as in any of the other modalities described here, the cutting element can be moved longitudinally into the tubular body until a material compression position located proximal to the lateral opening, the cutting element being configured to compress the material in the material collection chamber when the cutting element is in the material compression position. The cutting element of the modalities described here can also comprise a side cutting blade configured to cut the material that invades the side cover when the cutting element is in the cutting position. The cutting element can be configured in such a way that the material of the vascular lumen is cut with the cutting edge when the cutting element is in the extended position and the catheter is moved proximally into the vascular lumen and the material is cut with the lateral cutting blade when the cutting element is in the cutting position and the catheter is moved distally or proximally into the vascular lumen. The cutting element may comprise a cup-shaped surface oriented proximally and configured to direct the material removed from the vascular lumen into the collection chamber This embodiment of the invention, as well as the other embodiments described here, can also comprise means for directing the material removed from the vascular lumen proximally within the collection chamber and means for preventing the rotating axis from blocking the lateral opening when the cutting element is in the extended position.
In another embodiment, the invention is a catheter for removing material from within a vascular lumen. The catheter comprises a tubular body that has proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body. A rotating axis is disposed within the lumen of the tubular body. A cutting element is coupled to the rotating axis, the cutting element and the rotating axis forming a set together
Rotating T, the cutting element having a cutting edge, the cutting element and the rotating axis can be moved into the tubular body between the position in which the cutting element is contained within the lumen of the tubular body and an extended position cutting edge in which the cutting edge portion is extended through the side opening beyond an outer diameter of the tubular body. A material collection chamber is positioned inside the tubular body at a location proximal to the lateral opening. A rotating tip is connected to the distal end of the tubular body. The catheter includes a set of connectors to selectively couple and uncouple the pointer from the rotating assembly.
This mode can be equipped with the additional features described above. In addition, this modality may comprise a member of exposure of the cutting element, the member of ex | position of the cutting element and can be moved longitudinally into the tubular body between a distal position and a proximal position, the exposure member of the cutting element being configured in such a way that the movement of the exposure member of the cutting element a from the distal position to the proximal position when the cutting element is in the position in which the cutting element is contained within the lumen of the tubular body, results in the movement of the cutting element from the position within the lumen of the tubular body to the extended cutting position. The catheter may include a cable attached to a proximal portion of the tubular body, the cable including a power source, a motor coupled to the rotary axis, and a first control member, the first control member being attached to the rotary axis, the first control member being configured to move the rotating assembly between the uncoupled position and the coupled position. In a further embodiment, the invention is a catheter for removing material from within a vascular lumen. The catheter comprises a tubular body that has proximal and distal ends and a wall that defines a lumen, the tubular body having a first opening at the distal end and a second opening through the proximal wall of the end.
Distal mity. The catheter includes a first cutting element positioned at the distal end of the tubular body that is configured to cut the material from the vessel through the first opening when the catheter is moved distally through the vessel and a second cutting element position - swims proximally to the first cutting element that is configured to remove material from the vessel through the second opening when the catheter is moved proximally through the vessel.
In this embodiment, the catheter may also comprise a rotating axis disposed within the lumen of the tubular body, the second cutting element being coupled to the rotating axis, the second cutting element and the rotating axis forming a rotating assembly together. The second cutting element can include a cutting edge, the second cutting element and the rotating axis and can be moved into the tubular body between the position in which the second cutting element is contained within the lumen of the tubular body and an extended cutting position in which the cutting edge portion is extended through the second opening beyond an outer diameter of the tubular body. The first cutting element may comprise an abrasive rotating tip. The catheter may include a set of connectors for selectively coupling and uncoupling the rotating tip from the rotating assembly. The second cutting element may also comprise a side cutting blade configured to cut the material that injects the second opening when the second cutting element is in the position in which the second cutting element is contained within the body lumen. tube and a material collection chamber positioned inside the tubular body in a proximal location of the second opening.
In another embodiment, the invention is a catheter for removing material from within a vascular lumen. The catheter comprises a tubular body that has proximal and distal ends and a wall that defines a lumen, the tubular body having a first opening at the end distal a second opening through the proximal wall of the distal end. The catheter includes a first cutting element positioned at the distal end of the tubular body that is configured to cut the material to
: from the vessel through the first opening when the catheter is moved distally through the vessel, a second cutting element positioned E is proximal to the first cutting element that is configured to remove material from the vessel through the second opening when the catheter is moved proximally through the vessel and a third cutting element that is configured to remove material from the vascular lumen through the second opening when the catheter is stationary inside the vessel, when the catheter is moved distally through the vessel and when the catheter is moved proximally through the vessel
In this embodiment, the catheter can also comprise a rotating axis = disposed within the lumen of the tubular body, the second cutting element being coupled to the rotating axis, the second cutting element and the rotating axis forming a rotating assembly together.
The second cutting element may include a cutting edge, the second cutting element and the rotating axis and can be moved into the tubular body between the position in which the second cutting element is contained within the lumen of the tubular body and an extended cutting position in which the cutting edge portion is extended through the second opening beyond an outside diameter of the tubular body.
The first cutting element may comprise an abrasive rotating tip.
The catheter may also comprise a set of connectors for selectively coupling and uncoupling the rotating tip from the rotating assembly.
The third cutting element may comprise a side cutting blade attached to the second cutting element configured to cut the material that invaginates the second opening when the second cutting element is in the position in which the second cutting element is contained within the lumen of the tubular body.
The catheter may include a material collection chamber positioned within the tubular body at a location proximal to the second opening.
The exposure member of the cutting element can be selectively moved to control the extent by which the cutting edge is extended through the side opening.
In another embodiment, the invention is a method of removing
To material from within a treatment site within a vascular lumen with a catheter that has a tubular body, the tubular body having ex: proximal and distal tremors and a wall that defines a lumen, the wall having an opening lateral positioned near the distal end of the tubular body, a rotating axis disposed within the lumen of the tubular body and a cutting element coupled to the rotating axis, the cutting element having a cutting edge, the proximal end of the tubular body being connected to a control cable, the distal end of the tubular body being connected to a rotating cutting tip. The method involves advancing the tubular body through the vascular lumen until the rotating cutting tip is proximal to the treatment site; rotate the rotating tip while advancing the tubular body distally along the treatment site to position the lateral opening in an inward or distal location to the treatment site; moving the cutting element from the position within the tubular body to an extended cutting position in which the cutting edge portion extends through the side opening beyond an outer diameter of the tubular body; and removing the tubular body proximally through the vascular lumen with the cutting element in the extended cutting position to move the cutting edge along the treatment site to cut the material from the treatment site.
In this modality, the catheter can include a set of connectors to selectively couple and detach the rotary cutting tip from the rotary axis in which the step to rotate the rotary tip comprises rotating the rotary axis while the rotating cutting tip is attached to the rotating axis. In this modality, the step to proximally remove the tubular body with the cutting tip in the extended cutting position is performed while the rotating cutting tip is decoupled from the rotating axis. In this embodiment, the catheter may include a material collection chamber within the tubular body proximal to the lateral opening, and the method may also include moving the cutting element into the tubular body to the proximal position of the lateral opening to compress the material cut into the material collection chamber. In this embodiment, the step to move the cutting element to an extended cutting position may comprise moving the cutting element proximally into the tubular body - 'from a stored position distal from the lateral opening to a position of cut in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the lateral opening and move the cutting element radially outwards from the cutting position to the extended cutting position.
The catheter may include a lumen of guide wire which extends through the rotating axis, through the cutting element and through the rotating cutting tip and the step for advancing the tubular body through the vascular lumen may comprise advancing the tubular body over a guide wire inserted into the guide wire lumen. : In this embodiment, the catheter cable can include first and second control members and the step to move the cutting element to an extended cutting position can comprise manipulating the first control member to move the control element proximally. cutting and into the tubular body from a stored position distal from the lateral opening to a cutting position in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the lateral opening and manipulating the second member control to — move the cutting element radially outward from the cutting position to the extended cutting position.
In addition, the cutting element may have a second cutting edge and the method may also comprise advancing the tubular body distally through the vascular lumen with the cutting element in the extended cutting position to move the second cutting edge over the treatment site to cut material from the treatment site.
In this method, the step to advance the tubular body distally through the vascular lumen with the cutting element in the extended cutting position can be performed after the step to proximally remove the tubular body through the vascular lumen with the element cutting edge in the extended cutting position.
The method can also comprise rotating the tubular body around a longitudinal geometric axis of the tubular body to reorient the position of the cutting element within the treatment site.
'to.
In a further embodiment, the invention is a method of removing material from within a treatment site within a vascular lumen with a catheter that has a tubular body, the tubular body having proximal and distal ends and a wall which defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body, a rotating axis disposed within the lumen of the tubular body and a cutting element coupled to the rotating axis, the cutting element having first and second cutting edges, the proximal end of the tubular body being connected to a control cable. The method comprises advancing the tubular body through the vascular lumen until the lateral opening] is proximal to the treatment site; moving the cutting element from the position within the tubular body to an extended cutting position in which the portion of the first and second cutting edges extends through the side opening beyond an outer diameter of the tubular body; advancing the tubular body distally through the vascular lumen with the cutting element in the extended cutting position to move the first cutting edge along the treatment site to cut the material from the treatment site; and removing the tubular body proximally through the vascular lumen with the cutting element in the extended cutting position to move the second cutting edge along the treatment site to cut the material from the treatment site. In this embodiment, the step to proximally remove the tubular body through the vascular lumen with the cutting element in the extended cutting position can be performed after the step to advance the tubular body distally through the vascular lumen with the element cutting edge in the extended cutting position. The method can also comprise rotating the tubular body about a longitudinal geometric axis of the tubular body to reorient the position of the cutting element within the treatment site.
These and other aspects of the invention will become apparent from the following description of preferred embodiments, drawings and
It is the claims. Details of one or more embodiments of the invention are described in the attached drawings and in the description below. Other features, objectives, and advantages of the invention will become apparent from the description and drawings, and from the claims. - Description of the Drawings Figure 1a illustrates a partial perspective view of a cutting unit of a proximal end of an atherectomy catheter of the present invention. Figure 1b illustrates a side perspective view of the cutting unit of Figure 1a with an upper portion of the housing removed Figure 2a illustrates a perspective view of one end: distal portion of the atherectomy catheter of the present invention. Figure 2b shows a cross-sectional view of a distal end of the atherectomy catheter portion shown in figure 1a with a cutting element in a stored position.
Figure 3 illustrates a perspective view, partly cross-sectional and partly translucent, of the atherectomy catheter portion shown in Figure 2a with a cutting element in an operational position.
Figure 4a shows a cross-sectional view of a modality of a cutting element and a driving axis. Figure 4b shows a side view of an embodiment of a drive shaft of the present invention.
Figure 5 illustrates a perspective view of a cutting unit adapter of the present invention.
Figure 6 illustrates a perspective view of a rotatable tipped element of the present invention.
Figure 7 illustrates a partially translucent side view of the catheter portion with an alternative embodiment of the drive shaft.
Figure 8 illustrates a partially translucent side view of the modality in Figure 7 that has an improved characteristic of material collection.
Figure 9 shows a partially translucent side view of the catheter portion with an alternative embodiment of the drive shaft. Figures 10 to 12 illustrate side views partially trans- | of an alternative modality of a cutting element. Figures 13 to 15 illustrate an alternative mode of the drive shaft and a cutting unit adapter. Figure 16 is an alternative embodiment of the catheter configured for use as a quick-change catheter. Figures 17a, 17b and 17c illustrate the method of using the atherectomy catheter.
DETAILED DESCRIPTION The apparatus according to the present invention will comprise. in general, catheters that have catheter bodies adapted for intraluminal introduction into the target body lumen. The dimensions and other physical characteristics of the catheter bodies will vary significantly depending on the body lumen that is to be accessed. In the exemplary case of atherectomy catheters designed for intravascular insertion, the distal portions of the catheter bodies will typically be very flexible and suitable for introducing a guidewire at a target location within the vasculature. In particular, catheters can be designed for introducing "over the wire" when a guide wire channel extends fully through the catheter body or for introducing "quick change" where the guide wire channel extends only through a distal portion of the catheter body. In other cases, it may be possible to form a fixed or integral coil tip or a tip with a guide wire over the distal portion of the catheter or even dispense entirely with the guide wire. To facilitate the illustration, the guide wires will not be shown in all modalities, however, it must be understood that they can be incorporated into any of these modalities. Catheter bodies designed for intravascular introduction will typically have a length in the range from 50 cm to 200 cm and an outside diameter in the range from 1 French to 12 French (0.33 m: 1 French), usually from from 3 French to 9 French. In the case of catheters
coronary resins, the length is typically in the range from 125 cm to 200 cm, the diameter is preferably below 8 French, so | most preferred below 7 French, and even more preferred in the range from 2 French to 7 French. The catheter bodies will typically be - composed of an organic polymer which is manufactured using conventional extrusion techniques. Suitable polymers include polyvinyl chloride, polyurethanes, polyesters, polytetrafluoroethylenes (PTFE), silicon rubbers, natural rubbers and the like. Optionally, the catheter body can be reinforced with braid, helical wires, coils, axial filaments, or similar, in order to increase the rotational strength, column resistance, hardness, traction capacity and the like. Suitable bodies of Fr catheter can be formed by means of extrusion, with one or more channels being supplied when desired. The diameter of the catheter can be modified through expansion and thermal shrinkage using conventional techniques. The resulting catheters will therefore be suitable for introduction into the vascular system, which includes both coronary and peripheral arteries, using conventional techniques.
The lateral openings or cutting openings of the atheteromy catheters of the present invention can have a length of approximately 2 to 6 m. In other embodiments, however, the opening or cutting passage may be larger or smaller, however, it must be wide enough to allow the cutter to project at a distance that is sufficient to cut or reduce the volume of material from the body lumen in a treatment location.
Referring to figures 1A to 6, an atherectomy catheter 2 is shown. Catheter 2 has a cutting element 4, which is used to cut the lumen material from a blood stream such as an arterial or venous blood vessel. Catheter 2 may include an abrasive rotating tip 7, which is used to pierce any occlusion in a lumen that would otherwise prevent distal movement of the catheter through the vessel, which is discussed in more detail below. It should be noted that the abrasive tip is optional and the atherectomy catheter can be manufactured without
"no abrasive tip depending on the application.
The cutting element is mounted on the distal end of a flexible drive shaft 20. The 'drive shaft 20 extends through a lumen 21 in catheter 2. Catheter 2 is comprised of the tissue collection chamber 12. In some mo- —fits, tissue collection chamber 12 is a slotted metal tube with a polymer cover such as thermotactile tubing.
In other modes, the tissue collection chamber 12 is an extension of the catheter body 8 located proximal to the opening 6. The catheter body 8 can be equipped with the opening in the side wall with a tubing attached to the same (not shown) to facilitate the suction of cutting residues or the injection of fluid (which includes medications) through the annular space between the catheter body and the drive shaft 20. Catheter 2 is coupled to its end.
proximality by a cable such as the exemplary cutting unit 5. Cutting unit 5 consists of motor 11, the power source15 (for example, one or more batteries), microcomputer (not shown), housing 17 (the upper half of the housing has been removed as shown in figure 16), lever 13, lever 16 and by the connection set (not shown) to connect axis 20 to the drive motor 11. The cutting unit 5 can act as a cable for user to manipulate catheter 2. Lever 13 moves between a forward or distal position, and a backward or proximal position.
The lever 13 is operably coupled to the drive shaft 20 in such a way that the advance or retraction of the lever 13 causes the corresponding advance or retraction of the drive shaft 20, which in turn controls the position of the cutting element in the housing.
As will be discussed in greater detail later, when lever 13 is in the forward position, the cutting element 4 is in its stored position and when lever 13 is in the rear position, the cutting element 4 is in its cut.
Although not shown, the cutting unit 5 includes a switch to electrically connect the power source 15 to the motor 11, thereby causing the cutting element 4 to rotate. Lever 16 moves between a forward position or distal, and a backward or proximal position.
Lever 16 is coupled to
It is operable way to a traction wire 30. The traction wire 30 is attached to the plug 31. As will be discussed in more detail later, the lever 16 is in the front position when the cutting element is in position. - stored location. When the cutting element 4 is moved to its cutting position, the lever 16 is moved to the rear position and causes the cutting element to extend through the cutting passage.
The cutting element 4 is rotated about a longitudinal geometric axis LA when the axis 20 rotates. The cutting element 4 is rotated around 1 to 160,000 rpm, however, it can be rotated at any other suitable speed depending on the particular application. In addition, the description of catheters similar to catheter 2 that have cutting elements * similar to cutting element 4 is found in US Patent No. 7,771,444, entitled "Reducing the volume of the catheter", the content of which is incorporated here by reference .
The cutting element can be formed by a continuous part or it can be composed of multiple parts joined subsequently by means of welding, welding, brazing, adhesive bonding, mechanical interconnection or by other means. The cutting element includes a cutting unit adapter 4, which is adapted to receive and connect to the drive shaft, and a cutting edge 22, which is a radially outer edge 23 of the cutting element 4. The drive shaft can be connected to the cutting unit adapter by means of welding, welding, brazing or adhesive bonding. Alternatively, the connection can be made through mechanical interconnection or by other means.
A perspective view of the cutting unit adapter is shown in figure 5. In figure 5, the cutting unit adapter is shown separate from the rest of the cutting element. In this embodiment, the drive shaft 20 can be concave, having a lumen that forms a lumen of the guide wire. The cutting unit adapter has an opening configured to receive the distal end portion of the drive shaft. The cutting unit adapter can include a lumen 28 positioned to align with the drive shaft guide wire lumen and allow a guide wire
It is passed through the cutting unit adapter. The drive shaft can be made from any suitable material that has sufficient flexibility. For example, the drive shaft may comprise helically stranded strands, coiled strands or a solid tube. In an embodiment as shown in figure 4B, the drive shaft 20c is made of helically wound stainless steel wires, which can be wound to the left or to the right which have welded proximal and distal ends that do not extend in addition to the external dimension of twisted steel wires. In some embodiments, is the drive shaft 20c composed of multiple layers of helically wound yarns, and in some cases, adjacent layers of helically wound yarns they are coiled with an opposite tendency to use one sense more than another. The guide wire lumen extends from the proximal end to the distal end of the drive shaft 20 such that the catheter can be used as a suspended catheter with wire. In a fast catheter change mode shown in figure 16, the catheter is equipped with a shortened guide wire lumen. In the quick change mode, the drive shaft does not need to have a guide wire lumen and, therefore, can be optionally solid or at least does not need to be concave.
By manipulating lever 13, the cutting element 4 can be moved by an operator, between a stored position (figure 2B) and a cutting position (figure 3) in relation to an opening or cutting passage 6 in a body 8 of the catheter 2. In the stored position, the cutting element is positioned distal to the cutting passage within a delimited distal portion of the catheter. Moving from the stored position to the cutting position, the cutting element is moved proximally in a longitudinal or axial direction to the position into the cutting passage through the movement of lever 13 (and the drive shaft 20) proximally. As described in greater detail below, the cutting element 4 thereafter is moved out of relation to the opening 6 such that the portion of the cutting element 4 extends outwardly from the body 8 through the opening 6. More specifically, the port
: tion of the cutting element moves radially outwards to the position beyond an outside diameter of the catheter body at the location of the: cutting passage.
In one embodiment, the cutting element 4 can be positioned in relation to the body 8 and the opening 6 such that less than 90 degrees of the cutting element 4 are exposed to the cutting of the fabric.
In other ways, a larger or smaller part of the cutting element 4 can be exposed
without escaping the numerous aspects of the invention.
During the use of the catheter, the catheter is advanced through the vessel until the opening 6 is positioned adjacent or in a position exactly distal to the distal end of a treatment site of a vessel with cutting element 4 in the stored position.
The cutting element is then. moved proximally from the stored position to the cut position.
Once the cutting element has been moved to the proper: longitudinal position within the catheter body, it is angled out such that the cutting edge portion 22 of the cutting element extends beyond the diameter housing of the catheter.
The cutting element is generally cylindrical or tubular in shape.
The cutting edge 22 extends circumferentially around a proximal end of the cutting element and is generally oriented in a proximal direction.
Once the cutting element has been extended in this way, catheter 2 is pulled proximally through the vessel with the cutting element 4 in the operational position or in the cutting position as described in the additional details below.
As catheter 2 moves through the blood vessel with the cutting element 4 in the operating position or in the cutting position, the tissue material is cut by the cutting edge of the cutting element 4 and is directed into the tissue collection 12 positioned next to the cutting element 4. The tissue collection chamber 12 can be somewhat elongated to accommodate the tissue that has been cut.
As previously mentioned, the catheter body 8 can be equipped with an opening in the side wall at a proximal location that can be connected via tubing to the suction source in such a way that the residues created by the rotating cutting element 4 can be aspirated through the annular space between the catheter body and the drive shaft 20. The tissue collection chamber can be as long as the length of the catheter that | it is proximal to the passage.
The proximal portion of the catheter body may additionally have an opening or hole in the side wall (not shown) so that the tissue transported through the catheter can exit through the hole in the side wall.
However, since the tissue collection chamber is positioned close to the cutting passage, its length is not restricted by the size of the landing zone of the treatment site.
Therefore, the tissue collection chamber 12 can be designed to have any length
desired development.
The cutting element 4 is exposed through the opening 6 through: using a cutting blade exposure mechanism that comprises a traction wire 30 attached to a bush 31. As can be seen best in the cross section of figure 2B, bushing 31 has a curved or cam surface 32. When the treatment site has been reached, opening 6 will be positioned exactly distal from the lesion to be treated.
The lever 13 is then moved proximally to its rear position to move the drive shaft and the cutting element proximally to the position within the cutting passage.
To expose the cutting element through the cutting passage, the lever 16 is moved proximally to its rear position in such a way that the traction wire 30 is removed proximally by the operator while the catheter body and the section 4 are kept in a stationary position.
As the draw wire 30 is removed, the cam surface 32 of the bushing 31 acts against the angular ramp surface 14 of the cutting unit adapter 41, causing the cutting element to tilt out such that the cutting edge 22 of the cutting element extends beyond the external surface of the catheter housing and through opening 6, as shown in figure 3. The distance by which the cam surface 32 is moved in the proximal direction in relation to the ramp surface 14 of the cutting unit adapter 41 determines the distance that the cutting edge extends beyond the outer surface of the catheter.
If the traction wire 30 is removed at an even more proximal distance, the cam surface 32 of the bushing 31 will move even more proximally and act on the super. ramp surface 14 of the cutting unit adapter 41 to make it tilt out at a greater angle such that the cutting edge 22 extends an even greater distance through opening 6. The size or distance at which the cutting edge 22 extends through the opening 6 determines the depth of cut of the material removed from the lumen during the procedure. The depth of cut can be controlled by careful manipulation of the lever 16 in such a way that the diseased tissue can be removed from the treatment site at a pre-selected depth of cut. To facilitate precise control of lever 16, a. it can be equipped with a latch and ratchet mechanism, or it can be threaded onto the cable, or otherwise configured to 'allow incremental and / or positional locking movement of the bushing
31. The tensile tract 30 may comprise a metal wire or other suitable material and may have a substantially constant diameter. Alternatively, the traction wire 30 may have a flat or arcuate cross section. The traction wire 30 can be contained in the lumen 21 of the catheter 2 or it can be housed in a separate lumen (not shown) inside the catheter 2 The bushing 31 can have an arcuate transverse shape that extends into the lumen 21 of the catheter 2 180 degrees or less in such a way that it does not interfere with the extension of the cutting element through the opening. Once the cutting element 4 has been extended into the opening 6, the drive motor is engaged to rotate the cutting element (through the drive shaft 20) and the catheter 2 is removed proximally through the lumen of the vessel to remove material from the lesion. As best seen in figures 17A to 17C, catheter 2 can also comprise a rigid span or or a curved shape towards the distal end which can help to drive the cutting passage 6 and the cutting element 4 towards a wall of a corporeal lumen to improve treatment. Such rigid wingspan increases the catheter's operating range allowing the cutter to be propelled
'against a wall of the lumen along a lumen with a wider diameter.
: The cutting element 4 can have a cup-shaped surface 24, which directly cuts the fabric cut by the cutting edge 22 within the fabric chamber 12. The cutting edge 22 can be on a radially external border 23 of the cutting element 4. In some embodiments, the cup-shaped surface 24 may be a smooth, continuous surface, free of hollowed holes, teeth, burrs or other characteristics that affect the soft nature of surface 24 in at least half of the distance from the longitudinal geometric axis LA to the external radius of the cutting edge 22. In other embodiments, the cup-shaped surface may have a limited amount of hollowed holes, teeth, burrs or other characteristics. Catheters that have cutting elements similar to the. section 4 are found in US Patent Application Serial No. 12 / 768,281 by Moberg et al, entitled "Methods and Devices for Cutting and Rubbing the Fabric", published as US Patent Application US 2010/0312263, the content of which is incorporated here by reference. Figure 6 is a cross-sectional perspective view of the optional rotating tip 7. Any of the modalities described here of the catheter can be equipped with a stationary tip or a rotating tip depending on the application. As previously described, the drive shaft 20 is connected or in some way coupled to the cutter drive adapter 41 to form a rotating assembly. Figure 5 is a perspective view of the cutting unit adapter 41 of the decorte4 element. The cutting unit adapter 41 has a male hexagonal portion 27. The male hexagonal portion of the cutting unit adapter 41 matches a socket with hexagonal female adapter 47 of the element with rotating tip 7 (as shown in figure 2B) to couple the rotating tip to the rotating assembly when the cutting element 4 is in the stored position. When the cutting element is in the cutting position, the rotating tip is decoupled from the drive assembly. In other words, the corresponding portions of the cutting unit adapter
: (drive set) and the rotating tip form a set of connectors for selectively coupling and uncoupling the rotating tip from Ú | rotating assembly.
The stored position is obtained by moving lever 13 to the front position.
When the drive shaft is rotated while the cutting element is in the stored position, the rotational movement is transmitted to the cutting unit adapter, which in turn rotates the rotating tip 7. The rotating tip 7 includes an optional lumen 43 that extends from socket 47 to its distal end.
The lumen 43 aligns with the lumen 28 of the cutting unit adapter when the cutting element is in the stored position to accommodate a guide wire.
In this way, the lumen of the guidewire for this type of catheter over the com- it comprises the inner lumen of the concave drive shaft, the lumen 28 of the cutting unit adapter and the lumen 43 of the rotating tip.
However, it must be understood that although the corresponding portions of the cutting unit adapter and the tip are shown in this modality as being hexagonal in the cross section, other cross shapes such as square, triangular and similar could also be chosen, however that the correspondence relationship between the parties is reotationally secure.
It should also be understood that in catheter modalities that have a stationary tip, the adapter of the cutting unit can be modified to not include the male hexagonal portion or any other structure that matches the tip.
The swivel tip 7 is attached to the catheter housing by a retaining collar 35. The retaining collar 35 is fixedly attached to the body of catheter 8 by means of rivets, welding, adhesive and the like.
The retaining collar 35 is received in a retaining cavity 42 of the element with a rotating tip 7. The retaining collar 35 prevents axial movement of the rotating tip 7 and at the same time allows free rotational movement of the tip.
When the cutting element is in the stored position and the motor cutting unit is energized to rotate the drive shaft 20, the male hexagonal portion 27 of the adapter cutting unit 41, which is received inside the adapter socket 47 of the rotating tip element
It is 7, also rotates, thus rotating the abrasive rotating tip 7. Retaining collar 35, which is received inside the retaining cavity 42, allows the rotating tip element 40 to rotate freely and at the same time maintains a fit secure of the rotating tip element 40 in the catheter 2. The outer distal surface of the rotating tip element 7 can have a wrinkled abrasive surface 44 which can be composed of materials with rigid particles such as diamond, silicon carbide, oxide of aluminum, tungsten carbide, metal, hardened steel or other materials, which have a range of department sizes and can be defined by the size of gravel.
Similar abrasive cutting surfaces suitable for use as an abrasive surface 44 are found in US Patent Application Serial No. 12 / 768,281 to Moberg et al., Entitled "Methods and Devices for Cutting and Rubbing the Fabric", published as US Patent Application US 2010/0312263, the content of which is incorporated herein by reference.
During use, as the catheter is distally advanced through the vessel lumen, an occlusion or block such as a chronic total occlusion (CTO) can prevent the catheter from progressing.
In this example, the rotating tip 7 would fit and begin to rotate and the wrinkled abrasive surface 44 would begin to shear the layers of the CTO, or cause another blockage, until the rotating tip 7 would pierce the CTO (or another block) allowing catheter 2 was advanced to position the cutting passage in a location allowing the material to be removed from the lesion by the cutting element at the treatment site.
As previously mentioned, the catheter body can be equipped with an opening in the side wall at a proximal location which can be connected by the tubing to a suction source in such a way that the residues created by the rotating tip can be aspirated through the annular space between the catheter body and the drive shaft.
In practice, catheter 2 cuts the softer atheroma from a vessel wall into relatively wide strips and the cup-shaped surface 24 directs these strips through opening 6 inside the collection chamber 12. Since the collection chamber 12 is positioned close to the
n cover 6 and the cutting element 4, it is desirable to keep the passage between opening 6 and the collection chamber as free of obstruction as possible.
A potential obstruction that could hinder the movement of the cut material from the opening to the collection chamber is the action of the drive shaft.
As explained above, the cutting element is tilted towards the opening in order to extend the cutting edge out of the opening during the cutting procedure.
This inclination also affects the position of the drive shaft and tends to redirect the portion of the drive shaft exactly close to the cutting element in the direction of the opening.
The amount of obstruction caused by this deviation from the drive shaft when the cutting element is tilted is minimized by making the drive shaft extremely flexible in relation to its length or, in another mode, in relation to the length of the drive shaft immediately proximal to the cutter.
For example, a flexible drive shaft will bend sharply adjacent to its connection point or engage with the cutting element in such a way that it maintains its position close to the central geometric axis of catheter 2. The increased flexibility of the drive 20 also reduces any resistive force of the drive shaft in the angular inclination of the cutting element 4. In the drive shafts formed from tubular, solid and concave material, the drive shaft can be equipped with cuts spiral (or otherwise directed cuts) S mechanically performed by a laser as seen in the cross section of figure 4A.
In some embodiments, the spiral cuts are made in the direction that contracts when the axis is rotated and the same make the connecting axis 20 more flexible along the spiral-cut portion exactly proximal to the point of coupling with the cutting element.
These spiral cuts allow the cutting element to freely tilt out of the side opening 6 while the position of the drive shaft 20 can be maintained within the housing and out of the way of the material being cut by the cutting element 4 and di-
into the collection chamber 12. In an alternative mode shown in figures 13 to
15, the drive shaft and the cutting element can be modified to further ensure that the drive shaft will not obstruct the H: passage between the opening and the collection chamber.
Figure 13 shows an alternative drive shaft 20d which has an enlarged ball 50 at its distal end.
Figure 14 shows an alternative adapter of the cutting unit 41a which has a socket 52 at its distal end shaped to receive the enlarged ball 50 of the drive shaft 20d.
Figure 15 is a cross-sectional view of the drive shaft 20d coupled to the cutter drive adapter 41a.
A distal region of the driving axis 20d adjacent to the enlarged ball 50 has a transverse hexagonal shape.
The cutting unit adapter 41a includes a lumen that tapers inwardly from the proximal end to socket 52. This tapered shape is configured to correspond to the transverse shape of the drive shaft adjacent to the enlarged ball.
In this mode, the connection between the drive shaft and the cutting unit adapter is mechanical.
The ball 50 is firmly retained inside socket 52 and it prevents any longitudinal movement of the drive shaft in relation to the cutting unit adapter.
The inner and tapered sides of the cutting unit adapter are dimensioned to prevent the drive shaft from rotating in relation to the cutting unit adapter.
However, the inner and tapered sides of the cutting unit adapter are dimensioned to allow a little rotational movement by the drive shaft in relation to the cutting unit adapter.
This configuration allows the cutting unit adapter 41a to be received and rotated by the drive shaft 20d and at the same time allows the cutting unit adapter to tilt or rotate around the extended ball 50. In this mode, when the cutting unit adapter 41a is tilted towards the cutting passage to expose the cutting element through the opening as previously described, the drive axis is configured to remain centered within the catheter body or part - less is not pushed towards the opening to a substantial degree.
And so, this mode reduces the potential for interference from the drive shaft in the cut material that passes from the cutting passage to the collection chamber. : An alternative catheter modality is shown in figures 7 and 8. Catheter 2A is shown so that the same or similar reference numbers for catheter 2A refer to the same or similar structures of catheter 2 and the entire discussion regarding equal characteristics or the like of catheter 2 is equally applicable here, unless otherwise noted. Compared to catheter 2, the driving shaft 20a, which received a narrowed diameter immediately proximal to the cutting element 4. This narrowed diameter presents less obstruction for the passage of the material from the cutting passage 6 to the collection chamber 12. From this Thus, catheter 2A - allows a greater facility for atheroma / tissue collection at a treatment site by providing additional space for atheroma / tissue: to be collected inside the catheter. It should be noted that the drive shaft 20a (or the drive axes of any of the other modes described here) could be additionally coated with a lubricant or Teflon to prevent the atheroma / tissue from sticking to the drive shaft 20th.
Figure 8 shows the catheter 2A which is equipped with features that improve the storage efficiency of the material in the collection chamber. In this mode, the cable or the control mechanism is modified to allow the drive shaft to be removed even more proximally, resulting in the proximal removal of the cutting element beyond the cutting passage. In this embodiment, the lever 16 is advanced distally, thus advancing the bushing 31 distally and allowing the cutting element 4 to return into the catheter body so that the cutting element does not extend through the passage cutting. The drive shaft and cutting element 4 are then pulled back proximally towards the operator while the catheter and housing remain stationary. When the cutting element is pulled back proximally and beyond the cutting passage, the cup-shaped surface 24 collects and retracts the atheroma / tissue into the catheter lumen within the collection chamber 12. This compresses atheroma / tissue and adds even more material storage capacity in catheter 2A. THE ! backward compression step can be done while the cutting element is being rotated although this is typically done without rotating the cutting element. It should be noted that the back compression system could be incorporated into any of the catheter modalities described here in order to increase the storage efficiency of the collection chamber. Another modality of the catheter is shown in figure 9. Catheter 2B is shown so that the same or similar reference numbers of catheter 2B refer to the same or similar structures of catheter 2 and the whole discussion of the same or similar characteristics of catheter 2 it is equally applicable here unless otherwise noted. Compared to the catheter: ter 2, the drive shaft 20b was equipped with drill blades 29 immediately proximal to the cutting element 4. As the drill blades 29 rotate together with drive shaft 20b, the atheroma / tissue entering the cutting passage is pulled away from the cutting area and the treatment site and into the collection chamber 12 of catheter 2B. This modality provides for easier collection of atheroma / tissue in a treatment site by providing additional space for the atheroma / tissue to be collected inside the catheter. It should be noted that the connection shaft 20b and the drill blades 29 could be additionally coated with a lubricant or Teflon to prevent the atheroma / tissue from sticking to the drive shaft 20b. In this embodiment, the cutting element can be elongated and have the characteristics of the cutting element 4c described below together with figures 10 to 12. As previously discussed, suction can be provided through catheter 2 to aid in the proximal removal of the material from inside the cutter element in the drill blades 29.
Figures 10 to 12 show another type of catheter. The 2C catheter is shown so that the same or similar reference numbers of the 2C catheter refer to the same or similar structures of catheter 2 and
. any discussion of the same or similar characteristics of catheter 2 is equally applicable here unless otherwise noted. Compared to catheter 2, catheter 2C has an elongated, cup-shaped surface 24c of the cutting element 4c with a radial surface area greater than previously described which corresponds to the cup-shaped surfaces of the cutting element 4. From additionally, the elongated cup-shaped surface 24c has an opening 25c with a side cutting blade 26c which aids in the material collection capacity. In this way, the cutting element 4c has two separate cutting structures and cutting positions.
In the first cutting position, as shown in figure 10, the cutting element 4c is extended at an angle through the opening 6 as - discussed above. In this position, the cutting edge 22 extends beyond and through the cutting passage 6. This cutting position is performed in the same way as described in relation to catheter 2. Specifically, catheter 2C is pulled out proximal way through the vessel along the treatment site (injury) to cut the plaque from the injury. In addition, the 2C catheter can be advanced distally while the material is cut by the cutting blade 26c, which enters through the opening 25c. The material entering the opening 25c will be pushed proximally by the additional material entering the opening 25c and will then be transported proximally using any of the tissue transport methods discussed here, which includes suction and / or blades. brokens if provided. In the second cutting position as shown in figures 11 and 12, the cutting element 4c is positioned inside the cutting pass, however, not tilted outwards. In this cutting position, the cutting element 4c is rotated and any material on the vessel wall that invades the cutting passage will be cut by the side cutting blade 26c.
In addition, the cutting passage 6 can be equipped with a cutting edge 6c against which the cutting blade 26c acts to cut the material more efficiently. In this cutting position, the catheter can remain stationary inside the vessel or it can be moved proximally or distally during the cutting process. Although not shown, the
'cutting device 4c includes a cutting unit adapter as shown in figure 5 if the catheter has an optional rotating tip, or a modified cutting unit adapter if the catheter has a stationary tip. Figure 16 shows an alternative catheter modality which was built to be used as a quick change catheter. The 2D catheter is shown so that the same or similar reference numbers of the 2D catheter refer to the same or similar structures of catheter 2 and any discussion of the same or similar characteristics of catheter 2 is equally applicable here unless otherwise noted. another way. The 2D catheter includes a tubular portion mounted on the side 55 that forms a lumen of a guide wire: relatively short for receiving a GW guide wire. The tubular portion mounted on the side 55 can be from 1 to 30 cm in length depending on the application and is positioned so as not to interfere with the cutting passage6. In addition, the tubular portion mounted on the side 55 is not attached to the rotating tip 7, if the catheter is equipped with a rotating tip.
Methods of using the catheters described here are shown in figures 17A, 17B, and 17C. A guidewire (GW) is percutaneously introduced into a patient's body and advanced to the region of interest in a patient's V blood vessel. If the treatment site (T) is a CTO, as shown in figure 17A, the guidewire may not be able to transpose the lesion or the occlusion material (M). Figure 17A illustrates a totally occluded lumen in which a guide wire (GW) was advanced to the proximal side of the occlusion material (M) at the treatment site (T). Catheter 2 was advanced over the guide wire to the position exactly proximal to the occlusion material (M). During feed, the cutting element remains in its stored position. In order to allow catheter 2 to treat this occlusion, it must first cross the occlusion. A catheter of the traditional anterior technique that must be forced along the lesion or the treatment would have to be blocked in favor of another form of treatment. With catheter 2, the occlusion material (M) can be safely transposed through the
Y energizing the drive motor to rotate the drive shaft.
Rotating the drive shaft with the cutting element in the stowed position makes the abrasive tip 7 rotate.
The abrasive surface at the tip 7 cuts through the regular, calcified material allowing the catheter to be slowly advanced through the lesion or through the occlusion material (M) until the cutting passage 6 is adjacent to the distal end of the lesion as shown in figure 17B.
The material cut by the rotating tip can be aspirated through the lumen of the catheter body as previously described.
With catheter 2 in the position shown in figure 17B, the lever 13 of the cable 5 is moved from the front to the rear position, which results in the proximal movement of the cutting element from the stored position to the r position.
With the cutting element in this position, the draw wire 30 is pulled proximally to cause the inclined bush 31 to move proximally to the ramp surface 14 of the cutting unit adapter.
This results in tilting out the cutting element 4 in the same manner as previously described to expose the cutting edge outside the cutting pass.
When the cutting edge is exposed, catheter 2 is pulled proximally along the lesion to cut the material from the lesion as shown in figure 17C.
The cut material is directed through the cutting passage and into the collection chamber.
This cutting process can be repeated by advancing and retracting the catheter along the treatment site until a sufficient amount of material has been removed.
At any time during this procedure, waste can be sucked through the catheter or a fluid can be introduced into the vessel through the catheter.
In addition, at any time during the procedure, the guidewire can be removed and debris can be sucked through the guidewire lumen or fluid can be introduced into the
through the guide wire lumen.
Although the method of use has been described in relation to the catheter2, the procedure for using catheters 2A, 2B, 2C and 2D is similar.
For example, catheter 2A, shown in figures 7 and 8, is used in a similar way.
The narrowed diameter of the drive shaft immediately proximal
It is the cutting element that allows the cutter to tilt through the cutting passage without causing the drive shaft to move sideways  which could obstruct the opening.
In addition, during use, the cutting element of catheter 2A can be removed proximally to accommodate the material that has been cut and then moved distally back to the cutting position.
The catheter 2B, shown in figure 9, is used in a similar way with the additional feature that the drill blades pull proximally the cut material that enters the cutting passage to reduce the possibility of the cutting passage becoming obstructed with the material cut during the cutting process.
Catheter 2C, shown in figures 10 to 12, can be used in the same manner as described above.
Specifically, in the first cutting position, the 2C catheter can be moved along the treatment site in the proximal direction to cut the material with cutting edge À 22 and can be advanced distally along the treatment site to cut the material with cutting blade 26c.
Catheter 2c can be moved distally and proximally along the treatment site as many times as necessary to remove a desired amount of diseased material.
In addition, the 2C catheter can be used with a cutting blade in the second cutting position, as described above.
In the second cutting position, catheter 2C will cut the material that invades opening 25c while the catheter is stationary or while catheter 2c is moved distally or proximally along the treatment site.
The 2D catheter, shown in figure 16, is used as described above except that it is advanced to the treatment site on a guidewire positioned in the guidewire lumen defined by the tubular portion mounted on the side 55. The description above and the accompanying drawings are provided for the purpose of describing the modalities of the invention and, therefore, are not intended to limit the scope of the invention in any way.
It will become apparent to people skilled in the art that various modifications and variations can be made without departing from the spirit and scope of the invention.
Thus, it is intended that the present invention covers the modifications and
spinning of this provided invention, which are within the scope of the appended claims and their equivalents.
In addition, although the: choices of materials and configurations have been described above in relation to certain modalities, a person skilled in the art will understand that the materials and configurations described here are applicable across all modalities.

权利要求:
Claims (56)
[1]
1. Catheter for the removal of material from within a vascular lumen I comprising: a tubular body that has proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the body tubular; a rotating axis disposed within the lumen of the tubular body; a cutting element coupled to the rotating axis, the cutting element having a cutting edge, the cutting element and the rotating axis can be moved longitudinally into the tubular body between a stored position in which the cutting element is positioned of ma-. distal edge in relation to the lateral opening and a cutting position in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the lateral opening; a cutting element display member, the cutting element display member can be moved longitudinally into the tubular body between a distal position and a proximal position, the cutting element display member being configured in such a way that the movement of the cutting element exposure member from the distal position to the proximal position when the cutting element is in the cutting position results in the movement of the cutting element from the cutting position to an extended position in the which portion of the cutting edge is extended through the lateral opening beyond an outer diameter of the tubular body; and a material collection chamber positioned inside the tubular body at a location proximal to the lateral opening.
[2]
2. The catheter according to claim 1, which further comprises: a rotating tip connected to the distal end of the body tumbles a set of connectors for selectively coupling and uncoupling the rotating tip from the rotating axis.
[3]
: 3. Catheter according to claim 2 in which the connector set comprises a first portion of the cutting element models! to mechanically connect with a second portion of the rotating tip.
[4]
A catheter according to claim 2, which further comprises a lumen of guide wire that extends through the rotating axis, through the cutting element and through the rotating tip in such a way that the catheter is configured as a suspended catheter with thread.
[5]
5. Catheter according to claim 2 in which the rotating tip comprises an abrasive surface.
[6]
6. A catheter according to claim 1 that still comprises: A cable attached to a proximal portion of the tubular body, the cable including a power source, a motor coupled to the rotating shaft, and first and second members control, the first control member being attached to the rotary axis, the second control member being attached to the cutting element display member, the first control member being configured to move the cutting element between the stored position and the cutting position, the second control member being configured to move the exposure member of the cutting element between the distal position and the proximal position.
[7]
A catheter according to claim 6 in which the cutting element display member comprises a traction wire having distal and proximal ends and an arc-shaped bushing, connected at the distal end of the traction wire, the proximal end of the traction wire being connected to the second control member.
[8]
8. A catheter according to claim 1 in which the cutting element can be moved longitudinally into the tubular body to a material compression position located proximal to the lateral opening, the cutting element being configured to compress the material in the chamber of material collection when the cutting element is in the material compression position.
[9]
A catheter according to claim 1 in which the cutting element further comprises a side cutting blade configured to: cut the material that invaginates the side opening when the cutting element is in the cutting position.
[10]
10. Catheter according to claim 9 in which the cutting element is configured such that the material of the vascular lumen is cut with the cutting edge when the cutting element is in the extended position and the catheter is moved proximally into the vascular lumen and the material is cut with the lateral cutting blade when the cutting element is in the cutting position and the catheter is moved distally or proximally within the vascular lumen.
[11]
. 11. Catheter according to claim 1, which further comprises means for proximally directing material removed from the vascular lumen: into the collection chamber.
[12]
12. Catheter according to claim 1 in which the cutting element comprises a cup-shaped surface oriented proximally and configured to direct the material removed from the vascular lumen into the collection chamber.
[13]
A catheter according to claim 1 which further comprises means for preventing the rotating axis from blocking the lateral opening when the cutting element is in the extended position.
[14]
14. Catheter for the removal of material from within a vascular lumen comprising: a tubular body that has proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body ; a rotating axis disposed within the lumen of the tubular body; a cutting element coupled to the rotating axis, the cutting element and the rotating axis forming a rotating assembly together, the cutting element having a cutting edge, the cutting element and the rotating axis can be moved into the body between the position in which the cutting element is contained within the lumen of the tubular body and a
"extended cutting position in which the cutting edge portion is extended through the lateral opening beyond an outer diameter of the tubular body; a material collection chamber positioned within the tubular body in a proximal location of the opening lateral, a swivel tip connected to the distal end of the tubular body, and a set of connectors for selectively coupling and uncoupling the swivel tip from the swivel assembly.
[15]
The catheter according to claim 14 in which the connector set comprises a first portion of the rotating assembly and a second portion of the rotating tip, the rotating assembly being able to be moved into the tubular body between an uncoupled proximal position and a " distal coupled position, the first and second portions being modeled to mechanically connect when the rotating assembly is in the distal coupled position.
[16]
16. Catheter according to claim 15 in which the first portion is not mechanically connected to the second portion when the rotating assembly is in the proximal position uncoupled.
[17]
17. The catheter according to claim 14 which further comprises a lumen of guide wire which extends through the rotating axis, through the cutting element and through the rotating tip in such a way that the catheter is configured as a catheter suspended with wire.
[18]
18. The catheter according to claim 14 in which the rotating tip comprises an abrasive surface.
[19]
19. The catheter according to claim 14 which further comprises: a cable attached to a proximal portion of the tubular body, the cable including a power source, a motor coupled to the rotating shaft, and a first control member, the first control member being attached to the rotary axis, the first control member being configured to move the rotary assembly between the uncoupled position and the position
coupled fection.
[20]
20. Catheter according to claim 14 in which the element: | The cutting element can be moved into the tubular body to a material compression position located proximal to the side opening, the cutting element being configured to compress the material in the material collection chamber when the cutting element is in the compression position. of material.
[21]
21. The catheter according to claim 14 in which the cutting element further comprises a side cutting blade configured to cut the material that invades the side opening when the cutting element is in the position in which the cutting element is contained within of the lumen of the. tubular body.
[22]
22. The catheter according to claim 21 in which the cutting element is configured such that the material of the vascular lumen is cut with the cutting edge when the cutting element is in the extended position and the catheter is moved proximally into the vascular lumen and the material is cut with the lateral cutting blade when the cutting element is in the position in which the cutting element is contained within the lumen of the tubular body and the catheter is moved in a way distal or proximal within the vascular lumen.
[23]
23. The catheter according to claim 14 which further comprises means for directing material removed from the vascular lumen proximally into the collection chamber.
[24]
24. The catheter according to claim 14 in which the cutting element comprises a cup-shaped surface oriented proximally and configured to direct the material removed from the vascular lumen into the collection chamber.
[25]
25. The catheter according to claim 14 which further comprises means for preventing the rotary axis from blocking the lateral opening when the cutting element is in the extended cutting position.
[26]
26. The catheter according to claim 14 which further comprises:
º a cutting element display member, the cutting element display member can be moved longitudinally to: inside the tubular body between a distal position and a proximal position, the cutting element display member being configured in such a way - the movement of the cutting element's display member from the distal position to the proximal position when the cutting element is in the position in which the cutting element is contained within the lumen of the tubular body results in the movement of the cutting element a from the position within the lumen of the tubular body to the extended cutting position.
[27]
27. The catheter according to claim 14 which further comprises: - a cable attached to a proximal portion of the tubular body, the cable including a power source, a motor coupled to the rotating shaft, and: first and second members control, the first control member being attached to the rotary axis, the second control member being attached to the cutting element display member, the first control member being configured to move the rotary assembly between the uncoupled position and a coupled position, the second control member being configured to move the exposure member of the cutting element between the distal position and the proximal position.
[28]
28. Method of removing material from within a treatment site within a vascular lumen with a catheter that has a tubular body, the tubular body having proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body, a rotating axis arranged within the lumen of the tubular body and a cutting element coupled to the rotating axis, the cutting element having a cutting edge, the proximal end of the tubular body being connected to a control cable, the distal end of the tubular body being connected to a rotating cutting tip, the method comprising: advancing the tubular body through the vascular lumen until the rotating cutting tip is proximal to the location of treatment;
* rotating the rotating tip while advancing the tubular body distally along the treatment site to position the lateral opening 'in a location within or distal to the treatment site; moving the cutting element from the position within the tubular body to an extended cutting position in which the portion of the cutting edge extends through the lateral opening beyond an outer diameter of the tubular body; and removing the tubular body proximally through the vascular lumen with the cutting element in the extended cutting position to move the cutting edge along the treatment site to cut the material from the treatment site.
[29]
29. The method of claim 28, wherein the catheter includes a set of connectors for selectively coupling and uncoupling the rotating cutting tip from the rotary axis and in which rotating the rotating tip comprises rotating the rotary axis while the rotating cutting tip is attached to the rotating shaft.
[30]
30. The method of claim 29 wherein the step for proximally removing the tubular body with the cutting tip in the extended cutting position is carried out while the rotating cutting tip is decoupled from the rotating axis.
[31]
31. The method of claim 28 in which the catheter includes a material collection chamber within the proximal tubular body of the lateral opening and in which the method further includes moving the cutting element into the tubular body to the proximal position of the side opening to compress the cut material inside the material collection chamber.
[32]
32. The method of claim 28 wherein the step of moving the cutting element to an extended cutting position comprises: moving the cutting element proximally into the tubular body from a stored distal position from the side opening to a cutting position in which the cutting element is contained within the lumen of the tubular body and longitudinally aligned with the opening
'side; and move the cutting element radially outward from the Z-po! cutting position to the extended cutting position.
[33]
33. The method of claim 28 in which the catheter includes a lumen of guide wire which extends through the rotating axis, through the cutting element and through the rotating cutting tip and in which the step for advancing the The tubular body through the vascular lumen comprises advancing the tubular body on a guide wire inserted into the guide wire lumen.
[34]
34. The method of claim 28 wherein the catheter handle includes first and second control members and in which the step for moving the cutting element to an extended cutting position comprises: manipulating the first member control to move: proximally the cutting element into the tubular body from a stored position distal from the side opening to a cutting position in which the cutting element is contained within the lumen of the tubular body and aligned in a way longitudinal with the lateral opening; and manipulating the second control member to move the cutting element radially outward from the cutting position to the extended cutting position.
[35]
35. The method of claim 28 wherein the cutting element has a second cutting edge, the method further comprising: advancing the tubular body distally through the vascular lumen as the cutting element in the extended cutting position to move the second cutting edge along the treatment site and cut the material from the treatment site.
[36]
36. The method of claim 35 wherein the step for advancing the tubular body distally through the vascular lumen with the cutting element in the extended cutting position is carried out after the step for proximally removing the tubular body through the vascular lumen with the cutting element in the extended cutting position.
[37]
37. The method of claim 28 which further comprises rotating the tubular body about a longitudinal geometric axis of the tubular body to reorient the position of the cutting element within the treatment site.
[38]
38. Method of removing material from within a treatment site within a vascular lumen with a catheter that has a tubular body, the tubular body having proximal and distal ends and a wall that defines a lumen, the wall having a lateral opening positioned close to the distal end of the tubular body, a rotary axis arranged within the lumen of the tubular body and a cutting element coupled to the rotating axis, the cutting element having first and second cutting edges: a proximal end of the tubular body being connected to a control cable, the method which comprises: Ô advancing the tubular body through the vascular lumen until the lateral opening is proximal to the treatment site; moving the cutting element from the position into the tubular body to an extended cutting position in which the portion of the first and second cutting edges extends through the side opening beyond an outer diameter of the tubular body; advancing the tubular body distally through the vascular lumen with the cutting element in the extended cutting position to move the first cutting edge along the treatment site to cut the material from the treatment site; and removing the tubular body proximally through the vascular lumen with the cutting element in the extended cutting position to move the second cutting edge along the treatment site and cut the material from the treatment site.
[39]
39. The method of claim 38 wherein the step for proximally removing the tubular body through the vascular lumen with the cutting element in the extended cutting position is carried out after the step for advancing the tubular body distally through the vascular lumen with the cutting element in the extended cutting position.
[40]
: 40. The method of claim 38 which further comprises rotating the tubular body about a longitudinal geometric axis of the tubular body to reorient the position of the cutting element within the treatment site.
[41]
41.Catheter for the removal of material from within a vascular lumen comprising: a tubular body that has proximal and distal ends and a wall that defines a lumen, the tubular body having a first opening at the distal end and a second opening through the wall near the distal end; a first cutting element positioned at the distal end of the tubular body and configured to cut the material from the vessel through the first opening when the catheter is moved distally a-. through the vessel; and% a second cutting element positioned proximally to the first cutting element and configured to remove material from the vessel through the second opening when the catheter is moved proximally through the vessel.
[42]
42. A catheter according to claim 41 which further comprises: a rotary axis disposed within the lumen of the tubular body, the second cutting element being coupled to the rotating axis, the second cutting element and the rotating axis forming a set together rotating.
[43]
43. A catheter according to claim 42 in which the second cutting element includes a cutting edge, the second cutting element and the rotating axis which can be moved into the tubular body between the position in which the second cutting element is contained within the lumen of the tubular body and an extended cutting position in which the portion of the cutting edge is extended through the second opening beyond an outer diameter of the tubular body.
[44]
The catheter according to claim 42 in which the first cutting element comprises an abrasive rotating tip.
"
[45]
45. A catheter according to claim 44 which further comprises:] a set of connectors for selectively coupling and uncoupling the rotating tip from the rotating assembly.
[46]
46. A catheter according to claim 43 in which the second cutting element further comprises a side cutting blade configured to cut the material that invaginates the second opening when the second cutting element is in the position in which the second cutting element is contained within the lumen of the tubular body.
[47]
The catheter according to claim 41, which further comprises: - a material collection chamber positioned inside the tubular body in a proximal location of the second opening.
[48]
'48. Catheter for the removal of material from within a vascular lumen comprising: a tubular body that has proximal and distal ends and a wall that defines a lumen, the tubular body having a first opening at the distal end and a second opening through the proximal wall of the distal end; a first cutting element positioned at the distal end of the tubular body and configured to cut the material from the vessel through the first opening when the catheter is moved distally through the vessel; a second cutting element positioned proximally to the first cutting element and configured to remove material from the vessel through the second opening when the catheter is moved proximally through the vessel; and a third cutting element configured to remove material from the vascular lumen through the second opening when the catheter is stationary within the vessel.
[49]
49. A catheter according to claim 48 which further comprises:
. a rotating axis disposed within the lumen of the tubular body, the second cutting element being coupled to the rotating axis, the second: cutting element and the rotating axis forming a rotating assembly together.
[50]
50. A catheter according to claim 49 in which the second cutting element includes a cutting edge, the second cutting element and the rotating axis which can be moved into the tubular body between the position in which the second cutting element is contained within the lumen of the tubular body and an extended cutting position in which the portion of the cutting edge is extended through the second opening beyond an outer diameter of the tubular body.
[51]
51. The catheter according to claim 49 in which the first. The cutting element comprises an abrasive rotating tip.
[52]
52. A catheter according to claim 51 which still comprises: a set of connectors for selectively coupling and uncoupling the rotating tip from the rotating assembly.
[53]
53. A catheter according to claim 50 in which the third cutting element comprises a side cutting blade attached to the second cutting element configured to cut the material that invaginates the second opening when the second cutting element is in the position in which the second cutting element is contained within the lumen of the tubular body.
[54]
54. A catheter according to claim 48 which further comprises: a material collection chamber positioned within the tubular body at a location proximal to the second opening.
[55]
55. A catheter according to claim 1 in which the cutting element display member can be selectively moved to control the extent by which the cutting edge is extended through the lateral opening.
[56]
56. A catheter according to claim 26 in which the cutting element display member can be selectively moved to
: r to control the extent by which the cutting edge is extended through the side cover.

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同族专利:

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公开号 | 公开日

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US9855072B2|2018-01-02|

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US9119662B2|2015-09-01|

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AU2011267862A1|2012-12-13|

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CA2800920C|2015-04-14|

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JP2013532027A|2013-08-15|

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KR20130018437A|2013-02-22|

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AU2011267862B2|2013-11-07|

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CN102946815B|2015-07-15|

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EP2742881B1|2015-10-07|

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JP5690928B2|2015-03-25|

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EP2742881A1|2014-06-18|

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US20150327884A1|2015-11-19|

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RU2012150415A|2014-07-20|

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EP2579791B1|2014-04-23|

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US20110306995A1|2011-12-15|

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EP2579791A1|2013-04-17|

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CA2800920A1|2011-12-22|

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WO2011159697A1|2011-12-22|

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RU2538174C2|2015-01-10|

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CN102946815A|2013-02-27|

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ES2482608T3|2014-08-04|

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KR101493138B1|2015-02-12|

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法律状态:
2020-08-18| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2020-09-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2020-10-20| B08F| Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]|Free format text: REFERENTE A 9A ANUIDADE. |

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2021-01-05| B11B| Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements|

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2021-11-03| B350| Update of information on the portal [chapter 15.35 patent gazette]|

优先权:

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申请号 | 申请日 | 专利标题

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US35448710P| true| 2010-06-14|2010-06-14|

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US61/354,487|2010-06-14|

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PCT/US2011/040348|WO2011159697A1|2010-06-14|2011-06-14|Material removal device|

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