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    • 专利摘要:
    device for a biological liquid treatment plant. the invention relates to a device comprising a base; a circuit comprising a bag comprising two flexible films and transmission network connectors, and a press (9) comprising a first housing (16) arranged vertically on the front face (5) of said base (2) and a second housing (17) mounted on said first housing (16), said first housing (16) and second housing (17) securing said bag for forming ducts; said pouch comprising the first side penetration openings and said first housing (16) comprising support rivets (106) in an upper part, the rivets of which (106) pass through said first openings.
    公开号:BR112012030050B1
    申请号:R112012030050-4
    申请日:2011-06-03
    公开日:2020-09-29
    发明作者:Sebastien Cirou；René Reinbigler；Virginie Buisson；Jean-Louis Weissenbach
    申请人:Emd Millipore Corporation；
    IPC主号:
    专利说明:

    [0001] The invention relates to a device for a biological liquid treatment plant, especially, but not exclusively, for the purification of a biopharmaceutical liquid, to obtain products, such as monoclonal antibodies, vaccines or proteins recombinants.
    [0002] It is known that bio-pharmaceutical liquids in general are obtained by culture in a bio-reactor and that they must be treated to obtain the required characteristics of purity, concentration, absence of viruses, etc.
    [0003] Purification is performed through a succession of treatments, such as clarification, to eliminate culture residues from the bio-reactor, and viral filtration sometimes followed by diafiltration and concentration through tangential flow filtration (TFF). There are other operations related to purification, such as chromatography.
    [0004] A number of types of containers containing liquids can be connected at the entrance of the circuit, such as the source container that contains the product to be treated, but also containers that contain a cleaning liquid, such as sodium hydroxide, rinsing, such as pure water or a buffer liquid, such as saline. In addition to the container for collecting the treated liquid, several other containers for collecting cleaning liquid, rinsing or buffer solution, or for collecting waste can be connected at the outlet of the circuit.
    [0005] In a production context, liquid treatments can only be carried out in sequence, the collection container for the first treatment potentially becoming the source container for the next treatment, and so on, until the last treatment.
    [0006] These treatments are conventionally carried out in exclusive installations comprising stainless steel pipes and other parts, such as tanks or filter housings, which require operations before and after the actual treatment, which are relatively expensive, especially in cleaning operations after the use.
    [0007] In recent years, these treatments have been performed alternatively in installations where the components in contact with the liquid are single-use components.
    [0008] The invention aims to produce a device that allows simple, economical and convenient implementation of treatments for biological liquids.
    [0009] For this reason, the invention relates to a device for a biological liquid treatment installation comprising: - a base having a front face; - a circuit comprising a number of connectors and a network for transmitting the liquid between said connectors, whose circuit comprises a pocket comprising two flexible films and said transmission network connectors, whose circuit further comprises a press comprising a first housing arranged vertically on said front face of said base and a second housing mounted on said first housing, said first housing and second housing operating simultaneously with said housing to form, between said flexible films, fixing said housing between said first housing and said second housing, the ducts of said transmission network; Said two flexible films of said bag being joined with each other and delimiting an area for treating said liquid according to a closed configuration, said connectors of the transmission network emerging inside and outside at least one side of said configuration; and said pouch comprising first penetration openings on one side of said pouch for attachment, and said first housing comprising tacks for attaching said pouch to an upper part of said first housing, said attachment studs passing through said first penetration openings of said bag.
    [0010] Due to the invention, the implementation of the circuit and especially the assembly of the bag on the first housing, which is placed on the front face of the base, is especially simple and convenient.
    [0011] More especially, when the bag is hung from the top of the first housing, which is in a vertical position, that bag is located directly in a substantially vertical position.
    [0012] According to a preferred embodiment, said base of said device comprises, on its front face, an inclined chassis that forms a console on which is placed the first housing, whose chassis comprises support claws, and said first housing it comprises pins fitted to said support claws.
    [0013] The implementation of the circuit, and especially the assembly of the first housing on the base, is even more convenient and safe.
    [0014] According to especially simple, convenient and economical characteristics of the device according to the invention: - said device contains a second closing system configured in such a way that it jointly involves said first housing and said second housing; and said bag further comprises at least a second penetration opening in a treatment zone for said liquid, between the ducts of the transmission network, allowing the passage of means of said second closure system to fix said bag in said circuit; - said second housing has a first orifice, said bag comprises at least a second full penetration opening in a treatment zone of said liquid, and said second closure system comprises at least one ball-shaped locking pin provided of a body, a head and spheres, and having a state of non-closure and a state of closure, said ball-shaped locking pin being fixed on said first housing, said head passing through said first housing and said second penetration opening emerging in said first orifice of said second housing, said spheres entering said head in said unclosed state of said pin and being projected from said head in said closed state of said pin; - said pouch comprises at least a third penetration opening on one side of said pouch, said first housing comprises at least one pin passing through said third penetration opening, and said second housing comprises at least a second orifice which receives said claw from said first carcass; - said circuit comprises instruments necessary for the treatment of said biological liquid, and especially valves to allow or prevent the passage of said liquid in said ducts, and / or sensors of physical-chemical values of said liquid, and said instruments being integrated in said first carcass; - said first housing comprises a first connector at the rear, and said base of said device comprises a second connector configured in such a way that it connects to said first connector to energize said instruments integrated in said first housing; and - said front face of said base comprises a structure with an opening, and said second connector is configured in such a way that it passes through said opening to connect with said first connector.
    [0015] According to an especially simple and convenient feature, the device comprises a movable or removable door, said device having a closed door position, in which the second housing is arranged on said door to form said circuit, and the which, moreover, has a different position than that of the closed door in which said bag is supported only by the first housing.
    [0016] The invention makes it possible to have a device provided with a base and a single door to perform different types of treatments, by means of a modular circuit in which the modules (the first frame, the second frame and the bag) are interchangeable, depending on the treatments performed.
    [0017] Furthermore, depending on the invention, it is possible to change the pouch very simply and very quickly, and if necessary, the first shell and the second shell in order to be able to carry out a new treatment, of the same type or of a different type.
    [0018] To be exact, to do this, just switch from the closed door position to the other position, that is, open or remove the device door, remove the bag, before or after disconnecting the tubes coming from the components of treatment neighbors that were previously connected to the connectors that come out of the bag, and then, if necessary, remove the first and second frames, respectively, from the base and the door. Finally, just install the first and second housing on the device, as well as a bag for the second treatment, control the passage from the other position to the closed door position, and connect the tubes to the connectors that come out of the bag.
    [0019] When the door is movable in relation to the base, just open it first and then close it again on the base.
    [0020] When the door is removable, just remove it first and then put it back on the base.
    [0021] In this way, it is possible to move from a first treatment, for example, a tangential filtration treatment, to a second treatment of another type, for example, a chromatography treatment, in a simple, economical, convenient and efficient way.
    [0022] It is clear that when the next treatment is different from the previous one, the first and second frame as well as the bag for the second treatment have characteristics (ducts for the transmission network, connectors) that are different from the first and second frame, as well as the bag from the previous treatment, to form a circuit adapted for the next treatment.
    [0023] Furthermore, in addition to the device according to the invention, the biological liquid treatment installation comprises, depending on the treatments to be carried out, one or more different devices, for example, juxtaposed to the device according to the invention.
    This or these other devices are provided with the neighboring treatment components mentioned above, formed especially by one or more pumps, for example, of the diaphragm type, and / or by a source container containing the product to be treated and / or by a container for collecting the treated liquid and / or by a chromatography column, these neighboring treatment components each being connected in the bag, directly or not.
    [0025] According to other particularly convenient features preferred, said device comprises a hinge system that supports said door in relation to said base, said hinge system is placed only on one side of said door to form, in the position with closed door, lateral spaces between said door and said base in relation to the rest of the perimeter of said door, to allow free access to the connectors of said bag.
    [0026] Because of the arrangement of the hinge system that allows the door to move in relation to the base, the lateral spaces are advantageously formed over a large part of the external perimeter of the door, between that door and the base.
    [0027] Therefore, the bag can comprise connectors that come out of a large part of its configuration with free access to it because of the lateral spaces, to connect the tubes from the neighboring treatment components (pumps and / or containers and / or column).
    [0028] In addition, as the door is connected with the base only on one side, for example, at the top of the door, the assembly of the bag in the first housing is greatly facilitated.
    [0029] More especially, it is possible to connect the bag to the neighboring treatment components before placing it in the first housing, without being hindered by the hinge, that is, when the bag is disposed of in the first housing, even though it is already connected with the tubes.
    [0030] Furthermore, due to the lateral spaces formed in accordance with the invention, the installation of the tubes that connect the bag with the neighboring treatment components is simplified, while preventing the tubes from passing in front of the door.
    [0031] Optionally, said hinge system comprises a single hinge placed in the corner of said door, and said hinge contains a first portion of the hinge fixed in said corner of said door, and a second portion of the hinge fixed on a side face of said device, whose side face is connected with said front face.
    [0032] Also optionally, the axis of said hinge is compensated by a joint plane formed between said first housing and the second housing in the closed door position.
    [0033] In accordance with still other preferred, simple, convenient and economical characteristics of the device according to the invention, the device comprises a first closing system for fixing said second housing in the structure of said door, whose first closing system comprises: - at least one lifting system placed on said structure; - at least one spring placed on said structure; - at least one rod connected to at least one said lifting system by a first end and at least one spring by a second end which is an end opposite the first end, said at least one rod comprising at least one screw closing and having an unopened position and a closed position; and - at least one locking device placed in a recess of said second housing; - said at least one lifting system being configured to connect the passage of said at least one rod between its closed position and its non-closed position; said at least one spring being configured to connect the passage of said at least one rod between its unopened position and its closed position; and said at least one closing screw being installed in at least one treatment device in the closing position of said stem and being removed from said at least one closing device in the unopened position of said stem.
    [0034] According to a second aspect, the invention relates to a bag for a circuit of a biological liquid treatment plant, characterized by the fact that it comprises: - two flexible films joined with each other and delimiting a zone of treating said liquid according to a closed configuration, connectors of a transmission network of said circuit that emerge inside and outside at least one side of said configuration; - at least one first penetration opening on one side of said configuration, the first penetration opening of which allows said bag to be installed in said circuit; and - at least a second penetration opening in the treatment zone of said liquid, between the ducts of the transmission network, allowing the passage of means for fixing said bag in said circuit.
    [0035] Advantageously, the pouch according to the invention comprises, over a large part of its configuration, connectors that emerge out of that configuration, whose connectors are configured in such a way that they are connected with tubes and themselves connected in the treatment components neighbors (pumps and / or containers and / or a column).
    [0036] According to a preferred, simple, convenient and economical feature of the pouch according to the invention, said pouch further comprises at least a third penetration opening on one side of said configuration.
    [0037] The disclosure of the invention will now continue with the description of the embodiments, given below by way of illustrative and non-limiting example, with reference to the attached drawings, in which: - figure 1 is a perspective view of a device for a biological liquid treatment installation according to a first embodiment of the invention, without the bag: - figure 2 is a view similar to figure 1, with the bag; figure 3 is a view on the right side of the device, with a right side panel partially turned; figure 4 is a view from the left side of the device, in the closed door position; figure 5 is a sectional view showing a hinge system that connects the door to a base of the device; figure 6 is a view from the inside of the door, alone, without the second frame, and showing the fixing system of that second frame on that door; - figures 7 and 8 are sectional views in VII-VII of figure 2, showing the system for fixing the second frame on the door, respectively, in the closed and closed state; figures 9 and 10 are sectional views, respectively in IX-IX and X-X of figures 7 and 8, respectively; figure 11 is an isolated perspective view of the system for fixing the first and second housings together; figures 12 and 13 are sectional views showing partially the first and the second housing, with the fixing system in the non-closed and closed states respectively; figure 14 is a rear view of the first housing, with the rear panel removed; figure 15 is a view similar to figure 14, with the rear panel; figure 16 is a partial view of the front of the device, with the first housing removed; Figures 17 and 18 are partly sectioned views of the device, showing diagrammatically the male and female connectors in the unconnected and connected state respectively; figure 19 is a diagrammatic view of the biological liquid treatment circuit of the installation; and - figure 20 is a perspective view of the bag; Figures 1 and 2 illustrate a device 1 for a biological liquid treatment facility (not shown).
    [0038] Device 1 has a generally parallelepiped shape.
    [0039] This device 1 comprises a base 2 having a first side face 3, a second side face 4 which is opposite the first side face 3, a front face 5 that joins the first and second side faces 3 and 4, and a rear face 6 which is opposite the front face 5 and which joins the second side faces 3 and 4.
    [0040] Device 1 further comprises a circuit 8 provided with a press 9 and a pocket 10, which contains a number of connectors 11 for liquid and a network 12 for directing the liquid between those connectors 11 from which the ducts can be seen 13 in figure 2.
    [0041] Press 9 comprises two housings 16 and 17, each formed from a solid block of rigid material.
    [0042] Here, housings 16 and 17 are made of polyoxymethylene (POM), also called acetal, and each of them, generally, has a parallelepiped shape.
    [0043] The housing 16 is mounted on the front face 5 of the base 2.
    [0044] Device 1 further comprises a port 20 connected to base 2.
    [0045] Frame 17 is mounted on that port 20.
    [0046] Device 1 has a closed door position in which the door 20 is closed and covers the housing 16, and another position in which the pocket 10 is supported only by the housing 16.
    [0047] In this other position, frame 17 is separated from frame 16.
    [0048] In the closed door position, bag 10 is inserted between the two housings 16 and 17.
    [0049] Device 1 is provided at the bottom, with a closed receptacle 186 which is intended to receive one or more tanks (not shown) containing a sachet, whose tanks form, for example, a container for collecting treated liquids, or a tailings container.
    [0050] This receptacle 186 is closed by a sliding panel 7 disposed on the front face 5 of the device 1, whose panel 7 is adapted to be moved in translation downwards and then towards the rear of the device 1 (see the arrows in the figure 1) to insert and remove the tanks.
    [0051] A control panel 14 is placed on top of the front face 5 of device 1.
    [0052] This control panel 14 is provided with a graphic touch interface 15 that allows the biological liquid treatment process to be checked and controlled.
    [0053] This control panel 14 is therefore placed at a height that allows a user to use it.
    [0054] To facilitate movement, device 1 is in the form of a cart mounted on four casters 18 (three of which can be seen in figure 1), with two casters located under the front face of the device 5 that constitute a brake 19 , and with the device 1 furthermore having two handles 21 on the respective opposite sides of the front face 5, in the vicinity of the respective side faces 3 and 4.
    [0055] Device 1 consists of a chassis 25 on its front face 5.
    [0056] As can be seen more specifically in figure 3, this chassis 25 is tilted.
    [0057] The chassis 25 has an external perimeter and an internal perimeter that are delimited on four sides, of which the left side 140 (visible in figure 16) and a right side 141 which are opposite sides, and a top side 143 and a bottom side 142 (visible in figure 16) which are opposite sides.
    [0058] Left 140 and right 141 each contain two L-shaped support claws 26 that emerge from the respective side and extend upwards.
    [0059] A support plate 27 is attached to the right side 141 of the chassis 25, between the two support claws 26.
    [0060] This support plate 27 is placed in the immediate vicinity under the support claw 26 located higher on the right side 141, to allow free access to the support claw 26 which is located on that same right side 141.
    [0061] The support plate 27 contains two fixing heads 28 on which a platform (not shown) is adapted to be fixed in order to be placed on it instruments that may be necessary for the treatment of the biological liquid.
    [0062] These instruments, for example, can be optional sets, such as sensors for measuring pH or conductivity and are chosen by the user according to the type of treatment to be performed.
    [0063] The base 2 of the device 1 further comprises the devices 29, which, with the complementary devices 40 of the door 20, allow the placement and fixation of that door 20 in the closed door position.
    [0064] There are three of the devices 29, which are placed in the corners of the chassis 25, respectively on the top right side, on the right side of the bottom, and on the left side of the bottom, as can be seen especially in figures 1 and 2.
    [0065] These devices 29, each one comprises a body, and an annular shoulder (not shown) a head attached to that annular shoulder, that head having the shape of a conical tube (figures 1 and 2) and being supplied internally with a rod 30 with a tapered tip. The body comprises a pneumatic chamber, a piston that is mechanically connected with the rod 30 with a conical tip, whose rod 30 is adapted to be extended inside the head.
    [0066] As can be seen in figures 1 to 3, the door 20 comprises a support 35 having a generally rectangular configuration.
    [0067] This support 35 has a first side 36, a second side 37 that is an opposite side to the first 36, a third side 38 that joins the first and second sides 36 and 37 and a fourth side 39 that is an opposite side to the third side 38 and that joins the first and second sides 36 and 37.
    [0068] The support 35 comprises three complementary devices 40 adapted to cooperate with the devices 29 of the base 2, whose complementary devices 40 are located, respectively, in the upper left, left bottom, and right bottom, as seen in the figures 1 to 3.
    These complementary devices 40 are provided with a first cylindrical portion 155 and a second cylindrical portion 156 which is hollow and is connected with the first portion 155 by a shoulder 157 (figure 16). This second portion 156 has a smaller diameter than the diameter of the first portion 155. In addition, the second portion 156 is provided with 3 openings 158 on its outer surface.
    [0070] These complementary devices 40 further comprise 3 spheres (not shown) each of them being capable of being projected from the second portion 156, passing through a respective opening 158.
    [0071] In the closed door position, each second portion 156 of a respective complementary device 40 of the door 20 is inserted in a respective head of a respective device 29 of the base 2.
    [0072] The devices 29 and the complementary devices 40 form, in pairs, a system of locking pins in the form of ball provided with a pneumatic lifting device of the type of double action with a spring (not shown), having an extended position and a stowed position, the operation of which is well known.
    [0073] The rod 30 of the device 29 is adapted to be inserted into the second hollow cylindrical portion 156 when the lifting device is in its extended position.
    [0074] In this position of the lifting system, the rod 30 pushes the balls until each one passes through an opening 158, thereby blocking the movement of the door 20 in relation to the base 2.
    [0075] The device 1 further comprises a hinge system through which the door 20 is rotated on the base 2.
    [0076] This hinge system is provided with a single hinge 42 comprising a first hinge portion 43 attached to the top right corner of the support 35 of the door 20, and a second hinge portion 44 attached to the side face of the base 2 of the device 1.
    [0077] The hinge portion 43 is fixed on the first side 36 of the support 35 by means of three fixing screws 158 (figure 6).
    [0078] As can be seen in greater detail in figure 5, the hinge portions 43 and 44, respectively, of the door 20 and the base 2 are joined by a rod 45 forming a pivotal connection.
    [0079] The hinge portion 44 of the base 2 is connected using six fixing screws 46 on the side face 3 of the base 2.
    [0080] An adjustment pad (not shown) located behind that portion of hinge 44 allows it to be adjusted in the best possible way.
    [0081] Furthermore, below in figure 5 it can be seen that the support 21 is fixed indirectly to that portion of the hinge 44 through an inclined plate 41 and fixing screws 185.
    [0082] At the top of the hinge portion 44, a mechanical spring 48 is mounted, assembled with a plastic lock 160 to facilitate the opening and closing of the door 20.
    [0083] The device also includes a position sensor 162 to check and provide security for opening and closing door 20, by detecting the closed door position and the other position.
    [0084] A pneumatic system 49 is also placed on top of the hinge portion 44 to produce a system (described below) for locking frame 17 and which is located on port 20.
    [0085] To that end, that system 49 comprises a connector 50 that is connected to both, the pneumatic power supply (not shown) and an opening 51 formed on the stem 45, whose opening 51 extends on the stem 45 from the connector 50 to the portion of hinge 43 that is on door 20.
    [0086] In the closed door position, as shown more especially in figure 4, the axis of rotation X around which the hinge portion 43 of the door 20 rotates, is balanced against a partition surface P formed between the housings 16 and 17 when they hold pouch 10 between them.
    [0087] This axial compensation towards the front of the device 1 of the X axis in relation to the partition surface P allows the lateral spaces 53 to be formed between the door 20 and the base 2 in the external perimeter of the door 20.
    [0088] Therefore, access, for example, to connector 11 of bag 10 which is illustrated in figure 4, is greatly facilitated.
    [0089] The door 20 also includes, in its support 35, a system 55 for fixing the frame 17 (figure 6).
    [0090] This system 55 comprises two lifting devices 56 placed on the respective opposite sides of the support 35, in its top portion, and the rods 57 which extend over a large portion of the height of the support 35.
    [0091] The lifting devices 56 are of the single-acting pneumatic type with a spring, which is not integrated in the lifting device 56, and are provided by connector 50 which can be seen in figure 5.
    [0092] These lifting devices 56, as will be seen in greater detail below, are each connected to a rod 57 and each of them is adapted to push that rod 57 between a closed position and an unclosed position of the system 55.
    [0093] Each rod 57 contains two locking pins 58.
    [0094] The system 55 further comprises two springs 59 placed on the bottom of the support 35, each spring 59 being connected to a stem 57 to push that respective stem 57 into its closed position and therefore advance the corresponding locking pins 58.
    [0095] The pouch 10 comprises two flexible films 65 and 66 connected with each other through a seal that delimits a closed contour, and the connectors 11 of the targeting network 12 (figures 2 and 20).
    [0096] Therefore, each of the 65 and 66 films is a PureFlex® film from the applicant.
    [0097] This is a coextruded film containing four layers, respectively, from the inside to the outside, a layer of ultra low density polyethylene (ULDPE) forming the material for contact with liquid, a copolymer of ethylene and vinyl alcohol (EVOH) ) forming a gas barrier, a layer of ethylene copolymer and vinyl acetate (EVA) and a layer of ultra low density polyethylene (ULDPE) forming the outer layers.
    [0098] The seal is a welded bead formed on the periphery of films 65 and 66.
    [0099] In addition to films 65 and 66 and connectors 11 for liquid, bag 10 contains a connector for the pneumatic agent (not shown) to form ducts 13 (13A to 13F in figure 20).
    [0100] The closed contour of bag 10 forms a liquid treatment zone 67, in which ducts 13 extend.
    [0101] The closed contour has a first side 68, a second side 69 that is opposite the first 68, a third side 70 that joins the first and second sides 68 and 69 and a fourth side 71 that is an opposite side to the third side 70 and that meets the first and second sides 68 and 69. The connectors of the targeting network 12 emerge in and out of the first, second, and third sides 68, 69, and 70, as can be seen more especially in figure 20 .
    [0102] The dimensions of bag 10 correspond to those of the surfaces of housings 16 and 17.
    [0103] As can be seen below, bag 10 is provided to be secured between housings 16 and 17 with one side of bag 10 in contact with the face of housing 16 and with the other face of bag 10 being in contact with the face of the carcass 17.
    [0104] On its fourth side 71, the pocket 10 further comprises three openings 73 for its attachment.
    [0105] These fixing openings 73 are aligned and spaced regularly, two of the openings 73 being located on respective opposite sides of the fourth side 71 of the pocket 10, and the other opening 73 being located in the center of the fourth side 71 of the pocket 10.
    [0106] These fixing openings 73, as will be seen below, are used to fix the pocket 10 in the housing 16.
    [0107] The pouch 10 further comprises, in its treatment zone 67, two openings 75 for locking the housings 16 and 17 together, these locking openings 75 having a larger diameter than the fixing openings 73.
    [0108] These locking openings 75 are located in the treatment zone 67 in the places where most of the ducts 13 are, because it is in these places that the pressure force is greatest during treatment. The locking openings 75 are therefore at least partially surrounded by the ducts 13.
    [0109] It will be seen below how the means to lock the housings 16 and 17 perform this locking and at the same time fix the pocket 10 in the circuit 8 between them.
    [0110] The pouch 10 also includes other fixation openings 77.
    [0111] One of the fixing openings 77 is located on the fourth side 71 of the bag in the vicinity of the fixing opening 73 located on the left side of the top of the bag 10, and the other fixing opening 77 is located on the opposite end, that is, towards the bottom of bag 10, in treatment area 67.
    [0112] These fixing openings 77, as will be seen below, are used to fix / position the door 20 in the closed door position of the device.
    [0113] As can be seen in figures 1 to 3, housing 17 has a reference surface 80, which is flat here, and a number of format channels 81 with a recession into that reference surface 80. This housing 17 has a first side 82 and a second side 83 which is a side opposite the first side 82, a third side 84 and a fourth side 85 which is a side opposite the third side 84, these third and fourth sides 84 and 85, each of them finding the first and second sides 82 and 83.
    [0114] On its fourth side 85, the housing 17 is provided with three fixing holes 86 for fixing the bag 10, which are placed, as shown below, facing the fixing openings 73 of the bag 10 in the position of closed door, with bag 10 fixed between housings 16 and 17.
    [0115] In addition, the housing 17 is provided with two other fixing holes 87 to secure the door 20 in the closed door position, one of which is placed on the first side 82 of the housing 17, and the other on the other end, in the direction of the housing bottom 17.
    [0116] As will be seen below, these two fixing holes 87 are placed in front of the fixing openings 77 of the pocket 10 in the closed door position, with the pocket 10 fixed between the frames 16 and 17.
    [0117] In a central zone, the housing 17 also comprises two other locking holes 88 with a larger diameter than the fixing holes 86 and 87 of that housing 17, whose locking holes 88 are used for the joint locking of the frames 16 and 17, as will be seen below.
    [0118] These locking holes 88 are located in places where most of the channels 81 are used to form the ducts 13, because it is in these places that the pressure force is greatest during the treatment. Locking holes 88 are therefore at least partially surrounded by channels 81.
    [0119] As will be seen below, these locking holes 88 are placed facing the locking openings 75 of the pocket 10 in the closed door position, with the pocket 10 fixed between the frames 16 and 17.
    [0120] As shown by figures 7 and 10, the housing 17 is provided with four locking devices 89, each formed in a recess of the housing body 17.
    [0121] These locking devices 89 are placed along the first side 82 of the housing 17, and two other locking devices 89 are placed along the second side 83 of the housing 17, that is to say, that the four locking devices 89 are in opposite pairs.
    [0122] As mentioned earlier, frame 17 is attached to support 35 of port 20, and the attachment of that frame 17 to port 20 will be described with reference to figures 7 to 10.
    [0123] Each lifting device 56 is provided with a body 90 consisting of a pneumatic chamber 91 and a movable piston 92 which extends by means of a rod, the lifting device of which is contained in support 35 of port 20, each piston 92 having an extended position and a retracted position in which the piston 92 has been moved through a predetermined space in relation to its extended position.
    [0124] Each lifting system 56 is connected pneumatically to the opening 51 formed in the rod 45 that connects the hinge portions 43 and 44.
    [0125] The lifting systems 56 are illustrated in the extended position in figure 7 and in the retracted position in figure 8.
    [0126] Each piston rod 92 is clamped to a rod 57, whose rod 57 is also connected to a spring 59.
    [0127] The pneumatic chamber 91, when under pressure, inclines piston 92 against spring 59. When piston 92 is at the end of travel, spring 59 is in the stowed position (figures 7 and 9) and piston 92 is in position extended.
    [0128] The rods 57 have therefore been moved down translationally, the housing 17 has been inserted against the sides 36 and 37 of the support 35 of the port 20, with its reference surface 80 facing outwards, and the locking pins 58 of each rod 57 were inserted in the corresponding recesses of the carcass 17.
    [0129] When the pneumatic chamber 91 of each lifting device 56 is at atmospheric pressure, spring 59 causes piston 92 to move through rod 57 towards the other end of the displacement position of that piston 92. When that position is reached, spring 59 is in the extended position, and the piston is in the stowed position.
    [0130] The rods 57 have therefore been moved translationally upwards with their locking pins 58 each having entered a locking device 89 of the housing 17 to lock that housing 17 in the port 20.
    [0131] Frame 16 has a flat reference surface 95 and formatting channels 96 in recession relative to reference surface 95, each facing a corresponding formatting channel 81.
    [0132] Generally, surfaces 80 and 95 have similar dimensions and the arrangement of format channels 96 is the mirror image of the set of format channels 81.
    [0133] Format channels 81 and 96 have a semi-elliptical section section.
    [0134] Surfaces 80 and 95 can be applied against each other with channels 81 and 96 according to each other to delimit a network of cavities that are each generally tubular.
    [0135] Housing 16 has a first side 145 and a second side 146 which is opposite the first side 145, a third side 147 and a fourth side 148 which is opposite the third side 147, the third and fourth sides of which 147 and 148 each of them meets the first and second sides 145 and 146.
    [0136] In addition, the housing 16, on the opposite side walls 98 and 99, has the pins 100 adapted to be fitted, as a result of a vertical movement from the top to the bottom when the housing 16 is against the chassis 25, on the support claws 26 placed on that chassis 25.
    [0137] In addition, on those same opposite side walls 98 and 99, the housing 16 has rods 101 for handling housing 16, whose rods 101 are longer than pins 100.
    [0138] This manipulation is performed by the user of device 1, or with the help of a winch, which, for example, may be electric.
    [0139] Thanks to the inclination and weight of the housing 16, and thanks to the fitting of the pins 100 on the support claws 26, the housing 16 is firmly fixed on the chassis 25.
    [0140] On its flat reference surface 95, the housing 16, moreover, has a recess portion 102 which extends downwards through an inclined surface 103, the inclination of which is directly into the device 1.
    [0141] This inclined surface 103 allows access to the recess 6 comprising the containers.
    [0142] The tubes (not shown) connected to the connectors 11 of the circuit 8, and specially placed in place of the third side 147 of the housing 16, can also be connected to the containers.
    [0143] On a bottom face 97, the housing 16 further comprises a channel 104 in the form of an inverted gutter emerging from the inclined surface 103 (figures 1 and 14).
    [0144] This channel 104 serves as an error-proof device when installing frame 16 on chassis 25 of base 2, so that the reference surface 95 is turned inwards.
    [0145] The housing 16 further comprises, at the location of its fourth side 148, three fixing rivets 106, two of which are placed on opposite sides of the housing 16, the third being placed substantially in the center of the fourth side 148 of the housing 16, with those three rivets 106 being spaced evenly from each other.
    [0146] As can be seen in figure 2, these rivets 106 are adapted to pass through the fixing openings 73 of the pocket 10 for the suspension of the last one on the housing 16.
    [0147] Furthermore, the farthest end of these same fixing rivets 106 is adapted to be inserted into the fixing holes 86 of the housing 17 in the closed door position.
    [0148] The housing 16 comprises two fixing pins 107 to fix the door 20, one of which is placed on the fourth side 148 of the housing 16 next to the fixing rivet 106 located on the top left of that housing 16, the other fixing pin 107 being located at the other end, that is, at the bottom of the housing 16, between two format channels 96 at the location of the third side 147.
    [0149] These fixing pins 107 are adapted to pass through the openings 77 of the pocket 10, and the farthest end of these fixing pins 107 is adapted to be inserted into the fixing holes 87 of the housing 17.
    [0150] The housing 16 also comprises two locking holes 108 which are placed in the places where most of the channels 96 are used to form the ducts 13, since it is in these places that the pressure force is greatest during the treatment . Locking holes 108 are therefore at least partially surrounded by channels 96.
    [0151] These locking holes 108 are placed facing the openings 75 of the pocket 10 when it is placed in the housing 16, and also facing the corresponding locking holes 88 of the housing 17 in the closed door position.
    [0152] The locking holes 108 of the housing 16 are passed through the ball locking pins 110, details of which will be shown below, for the joint fixing of the frames 16 and 17 when the door 20 is in its closed position, and for fixing pocket 10 to circuit 8.
    [0153] As can be seen more especially in Figures 11 to 13, each ball-shaped locking pin 110 corresponds to a body 111, and an annular shoulder 112 provided with a transverse face 113 and connected to a head 114.
    [0154] Four rods 115 are projected from the transverse face 113 to be inserted in the openings (not shown) formed in the body of the housing 16 to fix the body 111 in the housing 16.
    [0155] The body 111 comprises a pneumatic chamber 116 and a piston 117, the piston 117 being mechanically connected to a rod 118 with a conical tip.
    [0156] That rod 118 extends into the head 114 of pin 110.
    [0157] Three spheres 119 are placed to be projected from the head 114 passing through the openings formed in that head 114.
    [0158] Pin 110 is similar to a double action type lifting device and this pin 110 comprises two pneumatic connectors 120.
    [0159] The head 114 of each pin 110 passes through the corresponding locking hole 108 of the housing 16, the head 114 also passes through the corresponding locking opening 75 of the bag, and the head 114 finally emerges in a corresponding fixing hole 88 frame 17 in the closed door position.
    [0160] One of the connectors 120 of the pin 110 allows a first portion of the pneumatic chamber 116 to be pressurized, to act on the piston 117. When the piston 117 is at the end of its displacement, the balls 119 are in the extended position, that is to say say that they protrude from the head 114 to be extended into the locking hole 88 of the housing 17 (figure 13).
    [0161] The locking holes 88 are configured in such a way that, when the balls 119 are extended, the housings 16 and 17 are firmly fixed.
    [0162] For this purpose, the locking holes 88 comprise a first portion having a first diameter, the first portion of which is adapted to face the pouch 10 when that pouch is secured between housings 16 and 17, then a recess, and finally a second portion having a second diameter larger than the first diameter.
    [0163] Therefore, in the extended position of pin 110, the balls 119 of each pin 110 are projected into the second portion of the corresponding locking hole 88, the first portion of that locking hole 88 preventing the pin from loosening, at least ball lock 119.
    [0164] The other connector 120 allows a second portion of the pneumatic chamber 116 to be pressurized, this second portion being opposite the first portion, to move piston 117 towards the other end of the displacement position. When this position is reached, the balls 119 are in the stowed position, that is, they return into the head 114 (figure 12).
    [0165] In addition to frames 16 and 17, circuit 8 comprises, installed at the rear of frame 16, as shown in figure 14, the instruments required for the treatment of biological liquid.
    [0166] For example, blocking valves 125 are illustrated comprising actuators for blocking a duct 13 to prevent or allow liquid to pass through that duct 13, and sensors 126 of a psycho-chemical value, for example, pressure.
    [0167] A pneumatic distributor 128 and means for checking and controlling the execution of various treatments of that liquid are also illustrated, the means of which are formed, for example, by a checking and control unit 127.
    [0168] In the example illustrated in figure 14, the actuators of the valves 125, each of them, for example, comprise a body connected to the housing 16 and a movable fixing finger having a stowed position when the valve 125 is in the open position and a extended position when valve 125 is in the closed position (not shown).
    [0169] In the extended position, the movable finger is projected on one of the 96 channels (not shown).
    [0170] Each sensor 126 is attached to housing 16 according to a channel 96, with the furthest end of sensor 126 emerging into that channel 96, without actually having to touch the fluid (not shown).
    [0171] Such sensors are well known and comprise, for example, pressure sensors that measure pressure across the outer surface of the bag 10.
    [0172] The housing 16 also comprises, installed behind the housing 16, a female connector 130 that allows power to be supplied to the valves 125, sensors 126, the distributor 128 and the verification and control unit 127, which are integrated in that housing 16.
    [0173] The supply is therefore electric (for power supply and control) and pneumatic.
    [0174] This female connector 130 is located on the right side of the bottom of the housing 16 (seen from behind).
    [0175] As shown in figure 15, when the rear of the housing 16 is covered by a rear panel 132, only access to the female connector 130 is possible.
    [0176] A male connector 135 placed on base 2 of device 1 can be connected to female connector 130 of circuit 8.
    [0177] As shown in figures 16 and 17, the male connector 135 is mobile, by the action of a pneumatic lifting device 136 that carries the male connector 135 at its end, and this male connector 135 is adapted to pass through a opening 138 formed on the third side 142 of the chassis 25 for its connection with the female connector 130 (figures 18).
    [0178] A description of the assembly of circuit 8 will now be made.
    [0179] The housing 16 is attached to the chassis 25 of the base 2, by means of the pins 100 located in the support claws 26.
    [0180] The male and female connectors 135 and 130 are connected together by means of the pneumatic lifting device 136 which makes that male connector 135 mobile, for the electrical and pneumatic supply of circuit 8.
    [0181] The pocket 10 is then fixed by suspension in the housing 16, through the fixing openings 73 of that pocket 10 which are passed through the fixing rivets 106 of the housing 16.
    [0182] In the other position of the device in which the casing 17 is far from the casing 16, the casing 17 is mounted on the support 35 of the port 20 and is then fixed via the system 55 of rods 57 of the port 20.
    [0183] Door 20 is then closed to secure pouch 10 between housings 16 and 17. The device is therefore in the closed door position.
    [0184] When the door 20 is closed, its fixation, in particular, is made by the pins 107 of the housing 16, through the fixing openings 77 of the bag 10 and through the fixing holes 87 of the housing 17.
    [0185] Door 20 is locked on the front face 5 of the base 2 using devices 29 and 40, respectively, chassis 35 and door 20.
    [0186] The housings 16 and 17, below, are locked by the ball-shaped locking pins 110 which, in addition, allow the pocket 10 to be secured between the housings 16 and 17.
    [0187] The connection of the surrounding treatment components (not shown) with the connectors 11 of the bag 10 is then performed (if not done before the assembly of the bag 10), through tubes, especially flexible tubes.
    [0188] These treatment components around them are formed especially by one or more pumps, for example, of the diaphragm type, and / or by a source container containing the product to be treated and / or through a collection container. treated liquid and / or through a chromatography column.
    [0189] These surrounding treatment components are arranged in one or more devices, for example, juxtaposed to device 1.
    [0190] These other devices are advantageously trolleys like device 1.
    [0191] These connections are greatly facilitated by the lateral spaces formed around the bag 10.
    [0192] It is clear that these connections may be formed before fixing the pouch 10 by suspension in the housing 16, without being harmed later, that is, simultaneously with the suspension of that pouch 10 in the housing 16, by the hinge system.
    [0193] The bag 10 is then inflated: the connectors 11 for liquid are filled and a pneumatic agent is injected through the connector provided for that purpose (not shown).
    [0194] The effect of stock exchange inflation 10 is that films 65 and 66, respectively, are suitable for the face of the housing 16 with the surface 95 and channels 96, and the face of the housing 17 with the surface 80 and the channels 81.
    [0195] Ducts 13 of elliptical section are formed at the location of channels 81 and 96.
    [0196] Press 9 and bag 10 thus form a circuit 8 for treatment of biological liquid which is ready to be put into service.
    [0197] As the biological liquid is treated in the circuit formed by the press 9 and the bag 10, which must be protected against contamination, the bag 10 is supplied with plugs placed in each of the connectors 11 for liquid and in the connector for the agent pneumatic (not shown) and is sterilized, for example, by gamma irradiation. The pneumatic agent injected into the pouch 11 is purified.
    [0198] For example, the pneumatic agent is compressed air purified by a hydrophobic filter, such as an AERVENT® available from Millipore, connected to the filling connector (not shown).
    [0199] Figure 19 shows in diagram the circuit 8 supplied by a press 9 and a bag 10. In this circuit the valves 125A to 125G are formed respectively by an actuator, and by the portion of the housing 17 against which the duct 13 presses when it is compressed by the finger.
    [0200] The connector 11B serves to inject the liquid to be treated in a circuit formed by the duct 13E, by the feed container connected to the 11C connector, by the feed pump, from which the inlet side is connected to another connector of the supply and from which the discharge side is connected to connector 11 A, through duct 13A and the filter.
    [0201] In the injection of the liquid to be treated by connector 11B, all valves are open, except valves 125E and 125A.
    [0202] As soon as the product to be treated is transferred to the feed container, valves 125F and 1250 are closed, while the other valves are opened and the feed pump is put into operation, such that the liquid to be treated treated flows in the circuit mentioned above.
    [0203] When passed through the filter, the product to be treated is purified with the retentate passing into the duct 13E and the filtrate being passed to the duct 13D, and then being evacuated to the drain.
    [0204] When the liquid has been circulated enough in the circuit and has reached the required characteristics of purity and concentration, it is evacuated to the collection container connected to connector 11E, placing valve 125B in the closed position and valve 125C in the open position, the treated liquid then arrives at connector 11E through the passage through filter 151 where the liquid undergoes final filtration.
    [0205] It should be noted that, in addition to the operations described above, the circuit is capable of implementing several other operations through the direction network 12 formed by ducts 13A to 13F and valves125A to 125G.
    [0206] The sensors 126A to 126B are all pressure sensors here. They allow the proper operation of the installation to be checked, and especially, the detection of any occurrence of excess pressure (sensor 126 A) and ensure the proper operation of the filter (sensors 126B to 126D).
    [0207] In a variation not illustrated, the hinge system consists of a door having a horizontal flexing axis instead of a single hinge located in a corner. This door having a horizontal hinge axis is fixed to the top or bottom of the front face of the device base. Similar to a single hinge, this door having a horizontal flexing axis allows lateral spaces to be created over most of the bag structure.
    [0208] In a variation not illustrated, the door is removable, that is to say, it is independent of the base, and it is mounted on the base to be fixed in it.
    [0209] In a variation not illustrated, the lifting devices of the rod system are of the double action type, or are electric or hydraulic, instead of pneumatic.
    [0210] In a variation not illustrated, the ball-shaped locking pins are of the single acting type, or are electric or hydraulic, rather than pneumatic.
    [0211] In other variations not shown, other mechanisms may be used instead of the rod system, ball-shaped locking pins and support claws.
    [0212] In non-illustrated variations, stock exchange inflation is executed before the stock is fixed, or partially before and partially after the stock is fixed.
    [0213] In yet another variation not illustrated, there is no such prior inflation of the bag, because the bag's ducts are formed directly by directing the fluid into the bag at the time of treatment.
    [0214] In a variation not illustrated, instead of being dispersed over the same frame, the sensor or sensors of psycho-chemical value are placed in different frames; and / or no sensor is provided. The instrumentation, of course, is different, depending on the treatment of the biological liquid to be performed.
    [0215] In a variation not illustrated, the bag is triangular or circular, instead of being rectangular, and the box formed by the carcasses is adapted to the shape of the bag, as well as, if desired, the door and the base. For example, in the case of a triangular bag, the door has only three sides, and the hinge system is configured in such a way that it forms lateral spaces at least at the location of the remaining two sides.
    [0216] In other variations not shown: - instead of being a single piece, the carcasses are formed by a set of modulated members associated with each other to delimit the different portions of the circuit, whose members are provided with marks or markings to ensure that they are placed correctly in the relationship between them. The marks and markings comprise, for example, reference numbers or codes and may be of the RFID type; - the housings are of a material other than polyoxymethylene, for example, stainless steel, or aluminum, or of another plastic material, especially having high density, or of ceramic or wood; - the housing 16 comprises only two fixing rivets 106, or more than three, and in this case, the pouch 10 comprises respectively only two or more than three fixing openings 73, and for housing 17 it comprises two or more than three fixing holes fixing 86, those rivets, openings and holes being spaced or not equally spaced: - the housing 16 comprises more than two fixing pins 107 and in a specific case, the pocket 10 comprises more than two fixing openings 77, and the housing 17 comprises more two fixing holes 87, those rivets, openings and holes whether or not they are evenly spaced; - the housing 16 comprises more than two locking holes 108 and in one case, the pocket 10 comprises more than two locking openings 75, and the housing 17 comprises more than two locking holes 88; - the films in the bags are of a different material than PureFlex® film, for example, another film with several layers compatible with biological liquids, such as HyQ® CX5-14 film available from Hyclone industries, or Platinum UltraPac film available from Lonza company: - the psycho-chemical value measured by sensors 126 is temperature and / or pH and / or conductivity, in combination, or as an alternative to pressure; - the formatting channels have a circular section instead of a semi-elliptical section; - the pump or pumps of the other devices are of the peristaltic type instead of the diaphragm type; and - the device is not in the form of a cart, but is placed on another support, for example, on a table, and / or - all surrounding treatment components are arranged with the device on the same cart, or on the same support, which is different from a cart.
    [0217] It should be noted, more generally, that the invention is not limited to the described and represented examples.
    权利要求:
    Claims (12)
    [0001]
    1. Device for a biological liquid treatment installation, comprising: - a base (2) having a front face (5); - a circuit (8) comprising a number of connectors (11) and a network (12) for transmitting the liquid between said connectors (11), whose circuit (8) consists of a pocket (10) containing two flexible films (65, 66) and said connectors (11) of said transmission network (12), whose circuit (8) further comprises a press (9) comprising a first housing (16) arranged vertically on said front face (5) of the said base (2) and a second housing (17) mounted on said first housing (16), said first housing (16) and second housing (17) operating in conjunction with said housing (10) to form, between the said flexible films (65, 66), by fixing said pocket (10) between said first housing (16) and said second housing (17), ducts (13) of said transmission network (12); the two said flexible films (65, 66) of said bag (10) being joined together and delimiting an area (67) for the treatment of said liquid according to a closed configuration, the connectors (11) of said network transmission emerging inside and outside at least one side (68, 69, 70) of said configuration; and said bag (10) further comprising first penetration openings (73) on one side (71) of said bag (10) for its positioning, and said first housing (16) comprising rivets (106) to support said pocket (10) in an upper part of said first housing, said support rivets (106) passing through said first penetration openings (73) of said pocket (10); characterized by the fact that the device comprises a closing system configured in such a way that it jointly involves the first housing (16) and the second housing (17) and that the pocket (10) comprises at least a second penetration opening (75 ) in a treatment zone (67) of said liquid, between the ducts (13) of said targeting network (12), allowing the passage of means for fixing said closing system to fix said bag (10) in said circuit (8).
    [0002]
    2. Device according to claim 1, characterized in that said base (2) of said device (1) comprises, on its front face (5), an inclined chassis that forms a console (25) in which the device is placed. first housing (16), whose chassis (25) comprises support claws (26), and said first housing (16) comprises pins (100) fitted to said support claws (26).
    [0003]
    Device according to any one of claims 1 to 2, characterized in that said second housing (17) has a first orifice (88), said bag (10) comprises at least one second penetration opening (75) in a treatment zone (67) for said liquid, and said second closure system comprises at least one ball-shaped locking pin (110) provided with a body (111), a head (114) and balls (119) and having a non-closing state and a closing state, said ball-shaped locking pin (110) being attached to said first housing (16), said head (114) passing through said first housing (16) and said second penetration opening (75) and emerging in said first orifice (88) of said second housing (17), and said balls (119) entering said head (114) in said non-closing state of said pin (110) and protruding from said head (114) in said closing state of said pin (110).
    [0004]
    Device according to any one of claims 1 to 3, characterized in that said bag (10) comprises at least a third penetration opening (77) on one side (70.71) of said bag (10), the said first housing (16) comprises at least one pin (107) which passes through said third penetration opening (77) and said second housing (17) comprises at least one second hole (87) which receives said pin (107) ) of said first housing (16).
    [0005]
    Device according to any one of claims 1 to 4, characterized in that said circuit (8) comprises instruments (125, 126) necessary for the treatment of said biological liquid, especially valves (125) to allow or prevent the passage of said liquid in said ducts, and / or sensors (126) of physical-chemical values of said liquid, and said instruments (125, 126) being integrated in said first housing (16).
    [0006]
    Device according to claim 5, characterized in that said first housing (16) comprises a first connector (130) at the rear, and said base (2) of said device (1) comprises a second connector (135) ) configured in such a way that it connects to said first connector (130) to energize said instruments (125, 126) integrated in said first housing (16).
    [0007]
    Device according to claim 6, characterized in that said front face (5) of said base (2) comprises a structure (35) provided with an opening (138), and said second connector (135) being configured in such a way that it passes through said opening (138) to connect to said first connector (130).
    [0008]
    Device according to any one of claims 1 to 7, characterized in that it comprises a movable or removable door (20), said device having a closed door position, in which the second housing (17) is placed on the said door (20) to form said circuit (8), and which, in addition, has a different position from said closed door position in which said pocket (10) is supported only by the first housing (16).
    [0009]
    Device according to claim 8, characterized in that it comprises a hinge system that moves said door (20) in relation to said base (2), said hinge system being installed only on one side of said door (20) to form, in the closed door position, lateral spaces between said door (20) and said base (2) over the rest of a perimeter of said door (20), to allow free access to the connectors ( 11) of said bag (20).
    [0010]
    Device according to claim 9, characterized in that said hinge system comprises a single hinge (42) placed in a corner of said door (20), and said hinge (42) comprises a first portion of the hinge ( 43) attached to said corner of said door (20) and a second hinge portion (44) being attached to a side face (3) of said device (2), whose side face (3) is connected to said front face ( 5).
    [0011]
    Device according to claim 10, characterized by the fact that said axis (42) of said hinge is compensated by a joining plane (P) formed between said first housing (16) and the second housing (17) in the position of closed door.
    [0012]
    Device according to any one of claims 8 to 11, characterized by the fact that it comprises a first closing system (55) for wrapping said second housing (17) in a structure (35) of said door (20), whose the first closing system (55) comprises: - at least one lifting system (56) placed on said structure (35); - at least one spring (59) placed on said structure (35); - at least one rod (57) connected to said at least one lifting system (56) by a first end and at least one spring (59) by a second end which is an end opposite the first end, said at least a rod (57) comprising at least one locking pin (58) and having an unclosed and a closed position; and - at least one locking device (89) placed in a recess of said second housing (17); - said at least one lifting system (56) being configured to cause said at least one rod (57) to pass between its closed position and its non-closed position; - said at least one spring (59) being configured to cause said at least one rod (57) to pass between its unopened position and its closed position; and - said at least one locking pin (58) being fitted to said at least one locking device (89) in the closed position of said rod (57) and being removed from said at least one treatment device (89) in the position not closed of said rod (57).
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012030050B1|2020-09-29|DEVICE FOR A BIOLOGICAL LIQUID TREATMENT INSTALLATION
    BR112012027616B1|2020-10-27|device for a biological liquid treatment plant
    BR112012030040B1|2020-01-21|device for a biological liquid treatment plant
    BR112012030481B1|2020-12-29|bag for a circuit of a biological liquid treatment plant
    ES2431303T3|2013-11-25|Pump carriage for a biological liquid treatment facility
    BR112012027174B1|2020-10-27|bag for a circuit of a biological liquid treatment plant and device for a biological liquid treatment plant by means of tangential filtration
    同族专利:
    公开号 | 公开日
    CN102939145B|2016-01-20|
    CN102939145A|2013-02-20|
    WO2011154884A1|2011-12-15|
    EP2579964B1|2018-12-05|
    FR2960796A1|2011-12-09|
    KR20130050951A|2013-05-16|
    US9205955B2|2015-12-08|
    US10766666B2|2020-09-08|
    JP5782509B2|2015-09-24|
    JP2013531492A|2013-08-08|
    KR101512249B1|2015-04-14|
    ES2714748T3|2019-05-29|
    US20120138522A1|2012-06-07|
    EP2579964A1|2013-04-17|
    BR112012030050A2|2016-08-09|
    SG185560A1|2012-12-28|
    EP3461554B1|2021-07-21|
    ES2882725T3|2021-12-02|
    US20180111720A1|2018-04-26|
    EP3461554A1|2019-04-03|
    FR2960796B1|2014-01-24|
    US20130236130A1|2013-09-12|
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    法律状态:
    2018-04-10| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-01-08| B25G| Requested change of headquarter approved|Owner name: EMD MILLIPORE CORPORATION (US) |
    2019-02-26| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|
    2019-12-10| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2020-05-05| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-09-29| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1054517A|FR2960796B1|2010-06-08|2010-06-08|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR1054517|2010-06-08|
    PCT/IB2011/052448|WO2011154884A1|2010-06-08|2011-06-03|Device for a biological liquid treatment installation|
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