• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:

    公开号:BR112012028881B1
    申请号:R112012028881-4
    申请日:2011-05-27
    公开日:2018-03-20
    发明作者:Pohlman Matthias；Sikuljak Tatjana；Langewald Jürgen；Gewehr Markus
    申请人:Basf Se；
    IPC主号:
    专利说明:

    (54) Title: SYNERGIC MIXTURES, PESTICIDE COMPOSITION, METHOD TO CONTROL ANIMAL PEST, METHOD TO PROTECT PLANT PROPAGATION MATERIAL AND USE OF A MIXTURE (51) Int.CI .: A01N 43/90; A01N 43/40; A01N 53/00; A01P 7/04 (52) CPC: A01N 43/90, A01N 43/40, A01N 53/00, A01N 2300/00 (30) Unionist Priority: 05/28/2010 EP 10164305.4, 05/28/2010 US 61 / 349,228 (73) Holder (s): BASF SE (72) Inventor (s): MATTHIAS POHLMAN; TATJANA SIKULJAK; JÜRGEN LANGEWALD; MARKUS GEWEHR
    1/56 “SYNERGIC MIXTURES, PESTICIDE COMPOSITION, METHOD TO CONTROL ANIMAL PEST, METHOD TO PROTECT PLANT PROPAGATION MATERIAL AND USE OF A MIXTURE” Description of the Invention [001] The present invention relates to mixtures comprising as active components,
    1) the pesticidal compound of formula I
    (I) and
    2) one or more, for example 1,2 or 3, particularly a pesticidal compound II selected from the compounds of the following groups M.1. to M.28 as defined here:
    M.1. Organo (thio) phosphate compounds selected from the group consisting of acephate, azametiphos, azinfos-ethyl, azinfos-methyl, chloretoxifos, chlorfenvinfos, chlorephs, chlorpyrifos, chlorpyrifos-methyl, coumafos, cyanofos, demeton-Smetil, diazinonon, dinvon / diazinon, DDVP, dicrotofos, dimetoate, dimethylvinfos, disulfoton, EPN, etion, etoprofos, famfur, fenamiphos, fenitrotion, fention, flupirazofos, fostiazate, heptenofos, isoxation, malation, mecarbam, metamidofos, metidation, oxide, midate, midate, midate, mido methyl, paration, paration-methyl, fentoate, phorate, fosalone, fosmet, fosfamidon, foxim, pirimiphos-methyl, profenofos, propetamfos, protiofos, piraclofos, piridafention, quinalfos, sulfotep, tebupirimfos, temefos, tertofeffos, tertofeffos, tertofeffos, tertoflu, trichlorfon and vamidotion;
    Petition 870170089690, of 11/21/2017, p. 11/69
    2/56
    M.2. Carbamate compounds selected from the group consisting of aldicarb, alanicarb, bendiocarb, benfuracarb, butocarboxy, butoxycarboxy, carbaryl, carbofuran, carbosulfan, etiofencarb, phenobucarb, formethanate, furatiocarb, isoprocarb, metiocarb, methoxy, methoxy, pyrim, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy, methoxy. tiodicarb, thiofanox, trimetacarb, XMC, xylylcarb and triazamate;
    M.3. Pyrethroid compounds selected from the group consisting of acrinatrin, aletrin, d-cis-trans aletrin, d-trans aletrin, bifentrin, bioaletrin, S-cilclopentenyl bioalethrin, bioresmetrin, cycloprotrin, ciflutrin, beta-ciflutrin, cihalotrin, lambda-cida , gamma-cihalotrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenotrin, deltametrin, empentrin, esfenvalerate, etofenprox, fenpropatrin, fenvalerate, flucitrinate, flucitrinate, flucitrinate, flumetrinate, flumetrinate, flumetrinate, flumetrinate, flumetrinate, flumetrinate, flumitrinate , permetrin, fenotrin, praletrin, proflutrin, pyrethrin (piretrum), resmetrin, silafluofen, teflutrin, tetrametrin, tralometrine and transflutrin;
    M.4. Imitators of youth hormones selected from the group consisting of hydroprene, kinoprene, methoprene, phenoxycarb and pyriproxifen;
    M.5. Nicotinic receptor agonist / antagonist compounds consisting of acetamiprid, bensultap, cartap hydrochloride, clothianidin, dinotefuran, imidacloprid, thiamethoxam, nitenpiram, nicotine, spinosad (allosteric agonist), thiotridone, thiclamidine, thiacloprid, thiclamidine AKD1022, ie 1 - [(2-chloro-1,3-thiazol-5-yl) methyl] -3,5dimethyl-N-nitro-1,3,5-triazinan-2-imine;
    M.6. GABA-activated chloride channel antagonist compounds selected from the group consisting of chlordane, endosulfan, gamma-HCH (lindane); ethiprole, fipronil, pirafluprole and pyriprole;
    Petition 870170089690, of 11/21/2017, p. 12/69
    3/56
    M.7. Chloride channel activators selected from the group consisting of abamectin, emamectin benzoate, milbemectin and lepimectin;
    M.8. METI I compounds selected from the group consisting of fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpirad, tolfenpirad, flufenerim and rotenone;
    M.9. METI II and III compounds selected from the group consisting of acequinocil, fluaciprim and hydramethylnon;
    M.10. Oxidative phosphorylation decouplers selected from the group consisting of corfenapyr and DNOC, i.e. 4,6-dinitro-2-methylphenol;
    M.11. Oxidative phosphorylation inhibitors selected from the group consisting of azocyclotin, cihexatin, diafentiuron, fenbutatin oxide, propargite and tetradifon;
    M.12. Seedling disruptors selected from the group consisting of cyromazine, chromafenozide, halofenozide, methoxyfenozide and tebufenozide;
    M.13. Synergistic selected from the group consisting of piperonyl butoxide and tribufos;
    M.14. Sodium channel blocking compounds selected from the group consisting of indoxacarb and metaflumizone;
    M.15. Fumigants selected from the group consisting of methyl bromide, chloropicrin and sulfuryl fluoride;
    M.16. Selective food blockers selected from the group consisting of cryolite, pimetrozine and flonicamid;
    M.17. Mite growth inhibitors selected from the group consisting of clofentezine, hexithiazox and ethoxazole;
    M.18. Chitin synthesis inhibitors selected from the group consisting of buprofezin, bistrifluron, chlorfluazuron, diflubenzuron, fluPetition 870170089690, of 11/21/2017, p. 13/69
    4/56 cycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron;
    M.19. Lipid biosynthesis inhibitors selected from the group consisting of spirodiclofen, spiromesifen and spirotetramat; and
    M.20. The octapaminergic agonist amitraz; and
    M.21. Ryanodine receptor modulators selected from the group consisting of flubendiamide and the phthalamide compound (R) -, (S) -3chlor-N1- {2-methyl-4- [1,2,2,2-tetrafluor- 1 - (trifluormethyl) ethyl] phenyl} -N2- (1-methyl2methylsulfonylethyl) phthalamide (M21.1);
    M.22. Isoxazoline compounds selected from the group consisting of 4- [5- (3,5-dichloro-phenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3yl] -2-methyl-N-pyridin-2- ilmethyl-benzamide (M22.1), 4- [5- (3,5-dichloro-phenyl) -5trifluoromethyl-4,5-dihydro-isoxazol-3-yl] -2-methyl-N- (2,2, 2-trifluoro-ethyl) benzamide (M22.2), 4- [5- (3,5-dichloro-phenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-methyl-N- [ Acid (2,2,2-trifluoro-ethylcarbamoyl) -methyl] -benzamide (M22.3), [[2,2,2-trifluoro-ethylcarbamoyl) -methyl] -amide 4- [5- (3,5dichloro -phenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] -naphthalene-1-carboxylic (M22.4), 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4 , 5-dihydro-isoxazol-3-yl] -N [(methoxyimino) methyl] -2-methylbenzamide (M22.5), 4- [5- (3-chloro-5-trifluoromethylphenyl) -5-trifluoromethyl-4, 5-dihydro-isoxazol-3-yl] -2-methyl-N - [(2,2,2-trifluoroethylcarbamoyl) -methyl] -benzamide (M22.6); 4- [5- (3-chloro-5-trifluoromethyl-phenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl [(2,2,2-trifluoro-ethylcarbamoyl) -methyl] -amide] - naphthalene-1-carboxylic (M22.7), and 5- [5- (3,5-dichloro-4-fluorophenyl) -5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl] -2- [1 , 2.4] triazole-1-yl-benzonitrile (M22.8);
    M.23. Anthranilamide compounds selected from the group consisting of chloranthraniline, cyanthraniline, [4-cyano-2- (1-cyclopropylethylcarbamoyl) -6-methyl-phenyl] -amide of 5-bromo-2- (3-chloro-pyridin-acid) 2-il) Petition 870170089690, of 11/21/2017, p. 14/69
    5/56
    2H-pyrazol-3-carboxylic [2-chloro-4-cyano-6- (1-cyclopropylethylcarbamoyl) -phenyl] -amide of 5-bromo-2- (3-chloro-pyridin-2-yl) -2Hpyrazol- 5-Bromo-2- (3-chloro-pyridin-2-yl) 3-carboxylic (M23.2), [2-bromo-4-cyano-6- (1-cyclopropylethylcarbamoyl) -phenyl] -amide 2-pyrazol-3-carboxylic (M23.3), [2-bromo-4-chloro-6- (1-cyclopropyl-ethylcarbamoyl) phenyl]-5-bromo-2- (3-chloro-pyridin-2-) amide il) -2b-pyrazol-3-carboxylic acid (M23.4), [2,4-dichloro-6- (1-cyclopropyl-ethylcarbamoyl) -phenyl] -amide of 5bromo-2- (3-chloro-pyridin- 2-yl) -2H-pyrazol-3-carboxylic (M23.5), [4-chloro-2- (1 cyclopropyl-ethylcarbamoyl) -6-methyl-phenyl] -amide of 5-bromo-2- acid (3 -chloropyridin-2-yl) -2H-pyrazol-3-carboxylic (M23.6), N '- (2 - {[5bromo-2- (3-chloro-pyridin-2-yl) -2H methyl ester -2H -pyrazol-3-carbonyl] -amino} -5-chloro-3-methyl benzoyl) -hydrazinecarboxylic acid (M23.7), N '- (2 - {[5-bromo-2 (3-chloro- pyridin-2-yl) -2H-pyrazol-3-carbonyl] -amino} -5-chloro-3-methyl-benzoyl) -N'methyl-hydrazinac arboxylic (M23.8), N '- (2 - {[5-bromo-2- (3chloro-pyridin-2-yl) -2H-pyrazol-3-carbonyl] -amino} -5-chlorine methyl ester -3-methyl-benzoyl) -N, N'dimethyl-hydrazinecarboxylic (M23.9), N '- (3,5-dibromo-2 {[5-bromo-2- (3-chloro-pyridin) methyl ester -2-yl) -2H-pyrazol-3-carbonyl] -amino} benzoyl) hydrazinecarboxylic acid (M23.10), N '- (3,5-dibromo2 - {[5-bromo-2- (3-methyl acid ester) -chloro-pyridin-2-yl) -2H-pyrazol-3-carbonyl] -amino} -benzoyl) -N'methyl-hydrazinecarboxylic (M23.11) and N '- (3,5-dibromo- 2 {[5-bromo-2- (3-chloro-pyridin-2-yl) -2H-pyrazol-3-carbonyl] -amino} -benzoyl) -N, N'dimethylhydrazinecarboxylic (M23.12);
    M.24. Malononitrile compounds selected from the group consisting of 2- (2,2,3,3,4,4,5,5-octafluoropentyl) -2- (3,3,3-trifluoropropyl) malononitrile (CF2H-CF2-CF2 -CF2-CH2-C (CN) 2-CH2-CH2-CF3) (M24.1) and 2- (2,2,3,3,4,4,5,5-octafluoropentyl) -2- (3, 3,4,4,4-pentafluorobutyl) malonodinitrile (CF2H-CF2-CF2-CF2-CH2-C (CN) 2-CH2-CH2-CF2-CF3) (M24.2);
    Petition 870170089690, of 11/21/2017, p. 15/69
    6/56
    M.25. Microbial disruptors selected from the group consisting of Bacillus thuringiensis subspecies Israelensi, Bacillus sphaericus, Bacillus thuringiensis subspecies Aizawai, Bacillus thuringiensis subspecies Kurstaki and Bacillus thuringiensis subspecies Tenebrionis;
    M.26. Aminofuranone compounds selected from the group consisting of 4 - {[(6-bromopyrid-3-yl) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one (M26.1), 4 - {[ (6-fluoropyrid-3-yl) methyl] (2,2-difluoroethyl) amino} furan-2 (5H) -one (M26.2), 4 - {[(2-chloro1,3-thiazolo-5-yl ) methyl] (2-fluoroethyl) amino} furan-2 (5H) -one (M26.3), 4 - {[(6-chloropyrid-3-yl) methyl] (2-fluoroethyl) amino} furan-2 ( 5H) -one (M26.4), 4 - {[(6-chloropyrid-3-yl) methyl] (2,2-difluoroethyl) amino} furan-2 (5H) -one (M26.5), 4- {[(6Cloro-5-fluoropyrid-3-yl) methyl] (methyl) amino} furan-2 (5H) -one (M26.6), 4 - {[(5,6dichloropyrid-3-yl) methyl] ( 2-fluoroethyl) amino} furan-2 (5H) -one (M26.7), 4 - {[(6-chloro-5fluoropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one (M26.8), 4 - {[(6chloropyrid-3-yl) methyl] (cyclopropyl) amino} furan-2 (5H) -one (M26.9) and 4 - {[(6chloropyrid-3-yl) methyl ] (methyl) amino} furan-2 (5H) -one (M26.10);
    M.27. The insecticides selected from the group consisting of aluminum phosphide, amidoflumet, benclothiaz, benzoxide, biphenazate, borax, bromopropylate, cyanide, cyienopirafen, ciflumetofen, cinomethionate, dicofol, fluoroacetate, phosphine, pyridyl, pyridyl, pyridyl, pyridine , emetic tartar, sulfoxaflor, N-R'-2,2-dihalo-1-Rcyclopropanecarboxamide-2- (2,6-dichloro-a, a, a-trifluoro-p-tolyl) hydrazone or N-R'-2 , 2di (R ') propionamide-2- (2,6-dichloro-a, a, a-trifluoro-p-tolyl) -hydrazone, where R' is methyl or ethyl, halo is chlorine or bromine, R '' is hydrogen or methyl and R '' 'is methyl or ethyl, 8- (2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy) -3- (6-trifluoromethylpyridazin-3-yl) -3-azabicycle [3.2.1] octane ( M27.3); and
    M28: The bacillus species selected from the group consisting of the species Bacillus firmus CNCM 1-1582 and Bacillus cereus strain CNCM 1-1562;
    Petition 870170089690, of 11/21/2017, p. 16/69
    7/56 with the weight ratio of compound I and compound II being 1: 500 to 500: 1, often from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and especially from 1:25 to 25: 1.
    [002] These mixtures referred to above will hereinafter be called "inventive mixtures".
    [003] The inventive mixtures show synergistic action against animal pests, for example against invertebrate pests such as insects, mites or nematodes, particularly against arthropod pests such as insects or mites and especially against insects, ie the activity of inventive mixtures against these pests is greater than expected from the known activity of the individual compounds against these pests.
    [004] Therefore, the present invention also relates to the use of mixtures as described herein to combat animal pests, particularly invertebrate pests such as insects, mites or nematodes, especially arthropod pests such as insects and mites.
    [005] In addition, the invention relates to a method of pest control, which includes phytopathogenic animal pests phytopathogenic animal pests (particularly invertebrate pests such as insects, mites or nematodes, especially arthropod pests such as insects and mites) using inventive mixtures and the use of compound I and compound II for the preparation of such mixtures, and also compositions comprising such mixtures.
    [006] In one embodiment, the present invention provides methods for combating phytopathogenic animal pests (particularly invertebrate pests such as insects, mites or nematodes, especially arthropod pests such as insects and mites) comprising contact of the animal pest (of the insect, mite or nematode) or its food supply, habiPetição 870170089690, of 11/21/2017, p. 17/69
    8/56 tat, or its food supply, habitat, breeding sites or its locus with an effective amount as a pesticide of the inventive mixtures.
    [007] Furthermore, in another embodiment the present invention also relates to a method of protecting plants against the attack or infestation of phytopathogenic animal pests (particularly invertebrate pests such as insects, mites or nematodes, especially arthropod pests such as insects and mites) comprising the contact of the plant, or the soil or water in which the plant grows, or the plant propagating material with an effective amount as a pesticide of the inventive mixture.
    [008] Preferably, the present invention also comprises a method for protecting plant propagating material against animal pests (particularly invertebrate pests such as insects, arachnids or nematodes, especially arthropod pests such as insects and mites) comprising contacting the material of propagation of plants with an inventive mixture in amounts of effective pesticidal action. The invention also comprises plant propagation material treated with an inventive mixture.
    [009] The term plant propagation material is understood to mean all generative parts of the plant such as seeds and vegetative plant material such as carvings and tubers (for example potatoes), which can be used for plant multiplication. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, buds, buds and other parts of plants, including young plants and young plants, which must be transplanted after germination or after the soil is removed. These young plants can also be protected before transplantation through total or partial treatment by immersion or dumping. In a particularly preferred embodiment, the term propagating material denotes seeds.
    Petition 870170089690, of 11/21/2017, p. 18/69
    9/56 [010] The present invention also relates to mixtures of plant protection active substances that have synergistically enhanced action to improve plant health and a method to improve plant health and / or yield growth, being that the plant, the locus where the plant grows or is expected to grow, or plant propagation material, from which the plant grows, are treated with an effective amount of an inventive mixture.
    [011] Compounds I and II as well as their pesticidal action and method for producing them are generally known.
    [012] For example, group II commercially available compounds can be found in The Pesticide Manual, 14th Edition, British Crop Protection Council (2006) among other publications.
    [013] Paraoxone and its preparation have been described in the Farm Chemicals Handbook, Volume 88, Meister Publishing Company, 2001. Flupirazophos was described in Pesticide Science 54, 1988, p.237-243 and in patent document US 4822779. AKD 1022 and its preparation described in patent document US 6300348. Anthranilamides M23.1 to M23.6 were described in patent document WO 2008/72743 and WO 200872783, those M23.7 to M23.12 in patent document WO2007 / 043677. Phthalamide M 21.1 is known from the patent document WO 2007/101540. The Alquinileter Compound M27.1 is described for example in patent document JP 2006131529. Organic sulfur compounds have been described in patent document WO 2007060839. The isoxazoline compounds M 22.1 to M 22.8 have been described for example in patent documents WO2005 / 085216, WO 2007 / 079162, WO 2007/026965, WO 2009/126668 and WO2009 / 051956. The aminofuranone compounds M 26.1 to M 26.10 have been described for example in patent document WO 2007/115644. Malononitrile compounds like those (M24.1) and (M24.2) have been described in WO patent documents
    Petition 870170089690, of 11/21/2017, p. 19/69
    10/56
    02/089579, WO 02/090320, WO 02/090321, WO 04/006677, WO 05/068423, WO 05/068432 and WO 05/063694. The compound of formula I, which bears the name IPAC [(3S, 4R, 4aR, 6S, 6aS, 12R, 12aS, 12bS) -3- (cyclopropanecarbonyloxy) 6,12-dihydroxy-4,6a, 12b-trimethyl-11 -oxo-9- (pyridin-3-yl) -1,2,3,4,4a, 5,6,6a, 12a, 12bdecahydro-11H, 12H-benzo [f] pyran [4,3-b] chromen -4-yl] methyl cyclopropanecarboxylate as well as its pesticidal action have been described in patent documents WO2006 / 129714 and WO2009 / 081851, insecticidal mixtures of these in patent document WO2008 / 108491 and methods for producing the compound are for example described in patent document WO2009 / 022702.
    [014] Spore Bacillus firmus CNCM 1-1582 and / or Spore B. cereus strain CNCM 1-1562 as described in American patent document No. 6,406,690, which is incorporated herein by reference in its entirety.
    [015] A typical problem that arises in the field of pest control resides in the need to reduce the dosage rates of the active substance in order to reduce or avoid unfavorable or toxicological effects to the environment, allowing, however, an effective pest control.
    [016] Another problem encountered is the need to have pest control agents available that are effective against a wide spectrum of pests.
    [017] There is also a need for pest control agents that combine knock-down activity (deactivation) with prolonged control, that is, fast action with long lasting action.
    [018] Another difficulty in relation to the use of pesticides is that the repeated and exclusive application of an individual pesticide compound in many cases leads to a rapid selection of animal pests, which have developed natural or adapted resistance against the active compound in question. Therefore, there is a need for pest control agents to help prevent or overcome resistance.
    Petition 870170089690, of 11/21/2017, p. 20/69
    11/56 [019] Another problem underlying the present invention is the search for compositions that improve plants, a process that is commonly and henceforth called “plant health”.
    [020] The term plant health comprises several types of plant improvements that are not associated with pest control. For example, advantageous properties that can be mentioned are improved crop characteristics: emergence, crop yields, protein content, oil content, starch content, more developed root system (improved root growth), improved stress tolerance ( for example against drought, heat, salt, UV, water, cold), reduced ethylene (reduced production and / or reception inhibition), increased fertilization, increased plant height, larger leaf depth, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less necessary elements (such as fertilizers or water), less necessary seeds, more productive tillers, early flowering, early grain maturity, less plant back (lodging) ), increased sprout growth, increased plant vigor, improved plant disposition and better and earlier germination; or any other advantages familiar to the person skilled in the art.
    [021] If used in connection with the treatment of plant propagating material (preferably seeds) the term plant health is equivalent to seed vitality Seed vitality manifests itself in a variety of factors. Examples of factors that are manifestations of the plant's vitality are:
    general visual appearance;
    root growth and / or root development;
    leaf area size;
    intensity of the green color of the leaf;
    Petition 870170089690, of 11/21/2017, p. 21/69
    12/56 number of dead leaves around the soil;
    plant height;
    plant weight;
    growth rate;
    plant layout density;
    germination compartment;
    emergency behavior;
    number of shoots;
    sprout type (quality and productivity) plant toughness, for example resistance to biotic or abiotic stress;
    presence of necrosis; senescence behavior.
    [022] Preferably, the term seed vitality denotes density of plant disposition, seed storage capacity and / or germination behavior.
    [023] Another object of several crop protection efforts to increase plant yield.
    [024] "Yield" should be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the appropriate sense, vegetables, nuts, seeds, wood for example in the case of forestry plants) or even flowers (for example in the case of garden plants, ornamental plants). Plant products can additionally be used and / or processed after cultivation.
    [025] According to the present invention, increased yield of a plant, particularly an agricultural, forestry and / or horticultural plant, preferably an agricultural plant means that the yield of a product of the respective plant is increased by a lesser amount 870170089690 , of 11/21/2017, p. 22/69
    13/56 on the yield of the same product d aplanta produced under the same conditions, but without the application of the mixture according to the invention.
    [026] The increased yield can be characterized, among other things, through the following improved plant properties:
    • increased plant weight • increased plant height • increased biomass such as increased overall fresh weight (FW) • increased grain yield • more tillers • broad leaves • increased crushed growth • increased protein content • increased oil content • content increased starch • increased pigment content.
    [027] According to the present invention, the yield is increased by at least 2%, preferably by at least 4%, more preferably by at least 8%, even more preferably by at least 16%).
    [028] Patent documents EP 2119361 and EP 2223599 describe various pesticidal mixtures which may, inter alia, comprise the compound of formula I.
    [029] However, the extraordinary synergistic plant and / or pesticide health action of the specific inventive mixtures as well as that defined at the beginning will not be described here, including that which such substances may have and especially their suitability for seed treatment purposes.
    Petition 870170089690, of 11/21/2017, p. 23/69
    14/56 [030] Therefore, it is the object of the present invention to provide pesticide mixtures that solve the problems of reducing the dosage rate and / or increasing the spectrum of activity and / or combining the deactivation activity with prolonged control agent and resistance management and / or promoting plant health.
    [031] It is also an object of the present invention to provide methods to increase plant health.
    [032] We found that this object is obtained in part or in its entirety through mixtures comprising the active substances defined at the beginning and after.
    [033] In this case, we have found a method to increase the health of plants, the plant being the place where the plant grows or is expected to grow or plant propagation material, from which the plant grows, are treated with an effective amount of the compound of formula I, preferably the material of plant propagation, from which the plant grows is treated with an effective amount of the compound of formula I. Such further treatment of material of propagation of plant produces an increase in seed vitality.
    [034] We have also revealed a method to increase plant health, with the plant, the place where the plant grows or is expected to grow, or the plant propagation material, from which the plant grows, are treated with an effective amount of a compound of formula I and one or more compounds II, preferably the plant propagating material from which the plant grows is treated with an effective amount of the compound of formula I and one or more compounds II. Such further treatment of plant propagation material produces an increase in seed vitality.
    Petition 870170089690, of 11/21/2017, p. 24/69
    15/56 [035] It was found that the mixtures as defined at the beginning show much greater action against animal pests (such as insects, arachnids or nematodes) compared to the control rates that are possible with the individual compounds and / or suitable for improve plant health when applied to plants, plant parts, plant propagation material (preferably seeds), or their locus of growth.
    [036] It was found that the action of the inventive mixtures goes far beyond the pesticidal action (action against insects, arachnids and nematodes) and / or the action of improving plant health of the compounds present in the mixture individually (synergism).
    [037] In particular, it was found that the action of the inventive mixtures goes far beyond the pesticidal action (action against insects, arachnids and nematodes and / or the action of improving plant health of the active compounds present in the mixture individually (synergism) if applied as a seed treatment.
    [038] Thus, these mixtures are also suitable for improving plant health when applied to plants, parts of plants, seeds, or their locus of growth, preferably to plants and plant propagating material, more preferably to seeds.
    [039] Furthermore, we find that simultaneously, that is, together or separately, the application of compound I and compound II or the successive application of compound I and compound II allows greater control of animal pests, compared to rates of controls that are possible with the individual compounds (synergistic pesticide mixtures).
    [040] Furthermore, we find that simultaneously, that is, together or separately, the application of compound I and compound II or successive application of compound I and compound II provides greater plant health effects compared to plnata health effects. that are possible
    Petition 870170089690, of 11/21/2017, p. 25/69
    16/56 with individual compounds (synergistic mixtures with synergism being synergism of plant health).
    [041] Hereinafter the compound of formula I will be called compound I.
    [042] In general, the weight ratios for the respective mixtures comprising compound I and compound II insecticides are 1: 500 to 500: 1, preferably 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [043] Mixtures comprising compound I and as compound II, a pesticide selected from the group M.3, and particularly selected from alpha-cypermethrin, bifentrin, cypermethrin, deltametrin, flucitrinate, lambda-cihalotrin, teflutrin and permetrin, where preferred compound I and compound M.3 are present particularly in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.3 from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [044] Mixtures comprising or consisting of compound I and bifenthrin are preferred. In this mixture, compound I and bifenthrin are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to bifenthrin from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1 : 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [045] Mixtures comprising or consisting of compound I and alpha-cypermethrin are also preferred. In this mixture, compound I and afacipermetrin are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to alfacipermetrin from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    Petition 870170089690, of 11/21/2017, p. 26/69
    17/56 [046] Mixtures comprising compound I and as compound II a pesticide selected from the group M.5, which is preferably selected from the group consisting of bensultap, cartap hydrochloride, nitenpiram, nicotine, spinosad, are preferred. espinetoram, tiacloprid, thiocyclam, thiosultap-sodium and AKD1022, particularly selected from the group consisting of acetamiprid, clothianidin, dinotefuran, imidacloprid, thiamethoxam, nitenpiram, espinosad, espinetoram and tiacloprid and specially selected from the group consisting of nitenpiram espinosad, espinetoram and tiacloprid. In these mixtures, compound I and the compound selected from the group M.5 are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.5 from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [047] Particularly preferred are mixtures comprising or consisting of compound I and spinosad. In this mixture, compound I and spinosad are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to spinosad from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [048] Mixtures comprising compound I and as compound II a pesticide selected from the group M.6, and particularly selected from the group consisting of ethiprole and fipronil are preferred. In these mixtures, compound I and the compound selected from the group M.6 are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.6 of 1: 500 to 500: 1, preferably 1 : 100 to 100: 1, particuPetição 870170089690, from 11/21/2017, p. 27/69
    18/56 widely from 1:50 to 50: 1 and more preferably and most preferably from 1:25 to 25: 1.
    [049] Mixtures comprising or consisting of compound I and ethiprole are particularly preferred. In this mixture, compound I and etiprole are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to etiprole from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [050] Mixtures comprising or consisting of compound I and fipronil are particularly preferred. In this mixture, compound I and fipronil are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to fipronil from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [051] Mixtures comprising or consisting of compound I and pymetrozine are preferred. In this mixture, compound I and pimetrozine are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to pimetrozine from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [052] Mixtures comprising compound I and as compound II a pesticide selected from the group M.7, and particularly selected from the group consisting of abamectin, emamectin benzoate, milbemectine lepimectin are preferred. In these mixtures, compound I and the compound selected from the group M.7 are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.7 from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    Petition 870170089690, of 11/21/2017, p. 28/69
    19/56 [053] Mixtures comprising or consisting of compound I and abamectin are particularly preferred. In this mixture, compound I and abamectin are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to abamectin from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [054] Mixtures comprising compound I and as compound II a pesticide selected from the group M.14, and particularly metaflumizone, are preferred. In these mixtures, compound I and the compound selected from the group M.14 are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.14 from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [055] Mixtures comprising compound I and as compound II a pesticide selected from the group M.23, and particularly selected from chloranthranilipole and cyanthranilipole are preferred. In these mixtures, compound I and the compound selected from the group M.23 are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound M.23 from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [056] Mixtures comprising compound I and as compound II a pesticide selected from the group M.26, and particularly 4 - {[(6-chloropyrid-3-yl) methyl] (2,2-difluoroethyl) amino} are preferred) furan-2 (5H) -one (compound M.26.5). In these mixtures, compound I and the compound selected from the M.26 group are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to
    Petition 870170089690, of 11/21/2017, p. 29/69
    20/56 M.26 compound from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [057] Mixtures comprising or consisting of compound I and sulfoxaflor are preferred. In this mixture, compound I and sulfoxaflor are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to sulfoxaflor from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1: 50 to 50: 1 and more preferably 1:25 to 25: 1.
    [058] Mixtures comprising compound I and as compound II a pesticide selected from the group M.28, and particularly selected from Bacillus firmus CNCM 1-1582 in synergistically effective amounts, are preferred.
    [059] A particular embodiment of the invention relates to mixtures comprising or consisting of compound I and pesticide compound II, where compound II is selected from the group consisting of abamectin, bifentrin, alpha-cypermetrin, metaflumizone, pimetrozine, chlorantraniliprole , cyanantraniliprole, sulfloxaflor, spinosad and 4 - {[(6-chloropyrid-3-yl) methyl] (2,2difluoroethyl) amino} furan-2 (5H) -one. In these mixtures, compound I and compound II are preferably present in synergistically effective amounts, preferably in a weight ratio of compound I to compound II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [060] Another embodiment of the particular invention relates to mixtures comprising or consisting of compound I and compound II pesticide, where compound II is selected from the group consisting of abamectin, bifentrin, and 4 - {[(6-chloropyridine- 3-yl) methyl] (2,2-difluoroethyl) amino} furan-2 (5H) -one. In these mixtures, compound I and compound II are preferably present in synergistically effective amounts, preferably in a
    Petition 870170089690, of 11/21/2017, p. 30/69
    21/56 weight of compound I to compound II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [061] As mentioned at the beginning, inventive mixtures in a preferred embodiment are used as a seed treatment. For seed treatment purposes, the following mixtures are preferred:
    [062] Mixtures comprising compound I and as compound II alpha-cypermethrin or teflutrin, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100 : 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [063] Mixtures comprising compound I and as compound II clothianidin, imidacloprid, thiamethoxam, acetamipride, dinotefuran, spinosad or spinol, particularly spinol or spinosad, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II of 1 : 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [064] Mixtures comprising compound I and as compound II fipronil, preferably in synergistically effective amounts, preferably in a weight ratio of compound I to fipronil from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [065] Mixtures comprising compound I and as compound II abamectin, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    Petition 870170089690, of 11/21/2017, p. 31/69
    22/56 [066] Mixtures comprising compound I and chloranthranilprole as compound II, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [067] Mixtures comprising compound I and compound II Bacillus firmus CNCM 1-1582 in synergistically effective amounts.
    [068] For seed treatment purposes, the following mixtures are most preferred:
    [069] Mixtures comprising compound I and chloranthranilprole as compound II, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [070] Mixtures comprising compound I and as compound II abamectin, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [071] Mixtures comprising compound I and as spinosad compound II, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [072] Mixtures comprising compound I and as compound II spinetor, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, 1 : 50 to 50: 1 and more preferably from 1:25 to 25: 1.
    Petition 870170089690, of 11/21/2017, p. 32/69
    23/56 [073] Mixtures comprising compound I and as compound II Bacillus firmus CNCM 1-1582 in synergistically effective amounts.
    [074] For seed treatment purposes, the following mixtures are most preferred:
    [075] Mixtures comprising compound I and chloranthranilprole as compound II, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [076] Mixtures comprising compound I and as compound II abamectin, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II from 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [077] Mixtures comprising compound I and as spinosad compound II, preferably in synergistically effective amounts, preferably in a weight ratio of compound I: II of 1: 500 to 500: 1, preferably from 1: 100 to 100: 1, particularly from 1:50 to 50: 1 and more preferably from 1:25 to 25: 1.
    [078] Each of the inventive mixtures mentioned above can also comprise one or more insecticides, fungicides, herbicides.
    [079] For use according to the present invention, the mixtures according to the invention can be converted into conventional formulations, for example solutions, emulsions, suspensions, dust, powders, pastes and granules. The form of use depends on the particular purpose intended; respectively, it must ensure a fine and uniform distribution of the mixtures according to the present invention. The formulations are prepared in a known manner (cf. US 3,060,084, EP-A 707 445 (for liquid concentrates),
    Petition 870170089690, of 11/21/2017, p. 33/69
    24/56
    Browning: "Agglomeration", Chemical Engineering, Dec. 4, 1967, 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, S. 8-57 und ff. WO 91/13546, US 4,172,714, US 4,144,050, US 3,920,442, US 5,180,587, US 5,232,701, US 5,208,030, GB 2,095,558, US 3,299,566, Klingman: Weed Control as a Science (J. Wiley & Sons, New York, 1961), Hance et al .: Weed Control Handbook (8th Ed., Blackwell Scientific, Oxford, 1989) and Mollet, H. and Grubemann, A .: Formulation technology (Wiley VCH Verlag, Weinheim, 2001).
    [080] Agrochemical formulations can also comprise auxiliaries that are common in agrochemical formulations. The auxiliaries used depend on the particular form of application and active substance, respectively.
    [081] Examples of suitable auxiliaries are solvents, solid vehicles, dispersants or emulsifiers (such as other solubilizers, protective colloids, surfactants and adhesives), organic and inorganic thickeners, bactericides, antifreeze agents, antifoaming agents, if coloring agents and binding agents or binders (eg seed treatment formulations) are required.
    [082] Suitable solvents are water, organic solvents such as medium to high boiling mineral oil fractions, such as kerosene or diesel oil, in addition to coal tar oil and oils of vegetable and animal origin, aliphatic, cyclic and hydrocarbons aromatics, for example toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes or their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, glycols, ketones, such as cyclohexanone and gamma-butyrolactone, fatty acid dimethylamides and fatty acid esters and strongly polar solvents, for example amines such as N-methylpyrrolidone.
    Petition 870170089690, of 11/21/2017, p. 34/69
    25/56 [083] Solid vehicles are minerals such as silicates, silica gels, talc, kaolin, limestone, lime, chalk, clay, loesse, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide , ground synthetic materials, fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate, ureas and products of plant origin, such as cereal flour, tree bark flour, wood flour and nutshell, cellulose powder and other solid vehicles.
    [084] Suitable surfactants (adjuvants, humectants, thickeners, dispersants or emulsifiers) are alkali metal, alkaline earth metal and ammonium salts of aromatic sulfonic acids such as ligninosoulphonic acid (Borresperse® type, Borregard, Norway) phenolsulfonic acid, naphthalenesulfonic acid ( type Morwet®, Akzo Nobel, USA), dibutylnaphthalene sulfonic acid (type Nekal®, BASF, Germany), and fatty acids, alkyl sulfonates, alkyl aryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol and hexa-, hepta- and sulfates sulfated octadecanolates, glycol sulfated fatty alcohol ethers, in addition condensed with naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, isooctylphenyl ethoxylated, ethylphenol, nonylphenol, alkylphenyl, polyphenylene glycol, glycerylene , condensates of alcohol and fatty alcohol / ethylene oxide, ethoxylated castor oil o, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, liquids from lignin-sulfite residue and proteins, denatured proteins, polysaccharides (for example methylcellulose), hydrophobically modified starches, polyvinyl alcohols (polyvinyl alcohol) Clariant, Switzerland), polycarboxylates (type Sokolan®, BASF, Germany), polyalkoxylates, polyvinylamines (type Lupasol®, BASF, Germany), polyvinylpyrrolidone and the copolymers thereof.
    Petition 870170089690, of 11/21/2017, p. 35/69
    26/56 [085] Examples of thickeners (ie compounds that provide modified flowability in relation to compositions, ie high viscosity under static conditions and low viscosity under agitation) are organic and inorganic polysaccharides and clays such as xanthan gum (Kelzan®, CP Kelco, USA), Rhodopol® 23 (Rhodia, France), Veegum® (RT Vanderbilt, USA) or Attaclay® (Engelhard Corp., NJ, USA).
    [086] Bactericides can be added to preserve and stabilize the composition. Examples of suitable bactericides are those based on dichlorophene and benzylalcohol hemi formal (Proxel® from ICI or Acticide® RS from Thor Chemie and Kathon® MK from Rohm & Haas) and isothiazoline derivatives such as alkylisothiazolinones and benzisothiazolinones (Acticide® MBS from Thor Chemie).
    [087] Examples of suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin.
    [088] Examples of antifoam agents are silicone emulsions (such as for example Silikon® SRE, Wacker, Germany or Rhodorsil®, Rhodia, France), long-chain alcohols, fatty acids, fatty acid salts, fluoro-organic compounds and mixtures of these.
    [089] Suitable dyes are pigments with low water solubility and water-soluble inks. Examples to be cited and the designations rhodamine B, CI red pigment 112, CI red solvent 1, blue pigment 15: 4, blue pigment 15: 3, blue pigment 15: 2, blue pigment 15: 1, blue pigment 80, yellow pigment 1, yellow pigment13, red pigment 112, red pigment 48: 2, red pigment 48: 1, red pigment 57: 1, red pigment 53: 1, orange pigment 43, orange pigment 34, orange pigment 5, green pigment 36, pigment green 7, white pigment 6, brown pigment 25, basic violet 10, basic violet 49, acid red 51, acid red 52, acid red
    Petition 870170089690, of 11/21/2017, p. 36/69
    27/56
    14, acid blue 9, acid yellow 23, basic red 10, basic red 108.
    [090] Examples of tacking agents or binders are polyvinylpyrrolidones, polyvinylacetates, polyvinyl alcohols and cellulose ethers (Tylose®, Shin-Etsu, Japan).
    [091] Powders, dispersion materials and dust can be prepared by mixing or grinding the mixture concurrently and, if necessary, other active substances, with at least one solid vehicle.
    [092] Granules, for example, coated granules, impregnated granules and homogeneous granules can be prepared by attaching the active substances to solid vehicles. Examples of solid vehicles are mineral soils such as silica gels, silicates, talc, kaolin, atapulgite, limestone, lime, chalk, clay, loesse, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers, such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate, ureas and products of plant origin, such as cereal flour, tree bark flour, wood flour and bark flour of walnut, cellulose powders and other solid vehicles.
    [093] Examples of formulation types are:
    1. Types of Composition for Water Dilution [094] i) Water-soluble concentrates (SL, LS) parts by weight of the compounds of the inventive mixtures are dissolved in 90 parts by weight of water or in a water-soluble solvent. Alternatively, wetting agents or other auxiliaries were added. The active substance dissolves after dilution with water. In this way, a formulation is obtained containing a content of 10% by weight of active substance.
    [095] ii) dispersible concentrates (DC)
    Petition 870170089690, of 11/21/2017, p. 37/69
    28/56 parts by weight of the compounds of the inventive mixtures are dissolved in 70 parts by weight of cyclohexanone with the addition of 10 parts by weight of a dispersant, for example polyvinylpyrrolidone. Dilution with water resulted in a dispersion. The active substance content is 20% by weight.
    [096] iii) emulsifying concentrates (EC) parts by weight of the compounds of the inventive mixtures are dissolved in 75 parts by weight of xylene with the addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (respectively 5 parts by weight). Dilution with water resulted in emulsion. The composition has a content of active substance of 15% by weight.
    [097] iv) Emulsions (EW, EO, ES) parts by weight of the compounds of the inventive mixtures are dissolved in 35 parts by weight of xylene with the addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (respectively 5 parts by weight). This mixture was introduced into 30 parts by weight of water by means of an emulsifying machine (Ultraturrax) and transformed into a homogeneous emulsion. Dilution with water resulted in emulsion. The composition has an active substance content of 25% by weight.
    [098] v) Suspensions (SC, OD, FS)
    In a ball mill, 20 parts by weight of the compounds of the inventive mixtures are combined with the addition of 10 parts by weight of dispersants and wetting agents and 70 parts by weight of water or an organic solvent to produce a suspension of fine active substance. Dilution with water resulted in a stable suspension of the active substance. The content of active substance in the composition is 20% by weight.
    [099] vi) Water-dispersible granules and water-soluble granules (WG, SG)
    Petition 870170089690, of 11/21/2017, p. 38/69
    29/56 parts by weight of the compounds of the inventive mixtures are finely ground with the addition of 50 parts by weight of dispersants and wetting agents and prepared as water-dispersible granules and water-soluble granules by means of applied techniques (eg extrusion, dispersible tower , fluidized bed). Dilution with water resulted in a dispersion or stable solution of the active substance. The composition has an active substance content of 50% by weight.
    [0100] vii) Water-dispersible powders and water-soluble powders (WP, SP, SS, WS) parts by weight of the compounds of the inventive mixtures are finely ground in a rotor-stator mill with the addition of 25 parts by weight of dispersants, wetting agents and silica gel. Dilution with water resulted in a dispersion or stable solution of the active substance. The active substance content of the composition is 75% by weight.
    [0101] viii) Gel (GF)
    In a stirred bullet mill, 20 parts by weight of the compounds of the inventive mixtures are crushed with the addition of 10 parts by weight of dispersants, 1 part by weight of a gelling agent and 70 parts by weight of water or an organic solvent to obtain a fine suspension of the active substance. Dilution with water resulted in a stable suspension of the active substance, obtaining a composition with 20% (w / w) of active substance.
    2. Types of Composition to be Applied Undiluted [0102] ix) Dustable powder (DP, DS) parts by weight of the compounds of the inventive mixtures are finely ground and intimately mixed with 95 parts by weight of finely divided kaolin. A powderable composition was obtained which has an active substance content of 5% by weight.
    Petition 870170089690, of 11/21/2017, p. 39/69
    30/56 [0103] x) Granules (GR, FG, GG, MG)
    0.5 parts by weight of the compounds of the inventive mixtures is finely ground and associated with 99.5 parts by weight of vehicles. Current methods are extrusion, spray drying or fluidized bed. Granules were obtained to be applied undiluted with an active substance content of 0.5% by weight.
    [0104] xi) ULV solutions (UL) parts by weight of the compounds of the inventive mixtures are dissolved in 90 parts by weight of an organic solvent, for example xylene. An undiluted composition to be applied with an active substance content of 10% by weight was obtained.
    [0105] Agrochemical formulations in general comprise between 0.01 and 95%, preferably between 0.1 and 90%, most preferably between 0.5 and 90% by weight of active substance. The compounds of the inventive mixtures are used in a purity of 90% to 100%, preferably from 95% to 100% (according to the NMR spectrum).
    [0106] The compounds of the inventive mixtures can be used as such or in the form of their compositions, for example in the form of directly atomizable solutions, powders, suspensions, dispersions, emulsions, oil dispersions, pastes, powder powders, dispersion materials, or granules, by means of atomization, spraying, dusting, dispersion, brushstroke, immersion or pouring. The forms of application depend entirely on the intended purposes. The aim is to ensure, respectively, the finest possible distribution of the compounds present in the inventive mixtures.
    [0107] Aqueous application forms can be prepared from emulsion concentrates, pastes or wettable powders (atomizable powders, oil dispersions) by adding water. To prepare oil emulsions, pastes or dispersions, substances as such or dissolved in an oil or
    Petition 870170089690, of 11/21/2017, p. 40/69
    31/56 solvent, can be homogenized in water by means of a wetting agent, setting agent, dispersant or emulsifier. Alternatively, it is possible to prepare concentrates composed of active substance, wetting agents, setting agents, dispersants or emulsifiers and, if necessary, solvents or oil and such concentrates are suitable for dilution with water.
    [0108] The concentrations of active substance in ready-to-use preparations can vary within relatively wide ranges. In general, they can be from 0.0001 to 10%, preferably from 0.001 to 1% by weight of the compounds of the inventive mixtures.
    [0109] The compounds of the inventive mixtures can also be used successfully in the ultra-low volume (ULV) process, making it possible to apply compositions comprising over 95% by weight of active substance, or even to apply the active substance without additives.
    [0110] Various types of oils, wetting agents, adjuvants, herbicides, fungicides, other pesticides, or bactericides can be added to the active compounds, if necessary not even immediately before use (tank mix). These agents can be mixed with the compounds of the inventive mixtures in a weight ratio of 1: 100 to 100: 1, preferably 1:10 to 10: 1.
    [0111] Compositions of this invention may also contain fertilizers such as ammonium nitrate, urea, potash and superphosphate, phytotoxicants and plant growth regulators and protective agents. These can be used sequentially or in combination with the compositions described above, if necessary also added only immediately before use (tank mix). For example, the plant (s) can be atomized with a composition of this invention either before or after being treated with fertilizers.
    Petition 870170089690, of 11/21/2017, p. 41/69
    32/56 [0112] The compounds contained in the mixtures as defined above can be applied simultaneously, that is, together or separately, or successively, and the sequence in the case of separate application has no effect on the result of the control measures .
    [0113] According to this invention, compound I and compound II are to be understood as meaning that at least compound I and compound II occur simultaneously at the site of action (ie animal pests such as insects, arachnids or nematodes to be controlled) or its habitats such as infected plants, plant propagating material, particularly seeds, surfaces, materials or the soil as well as plants, plant propagating material, particularly seeds, soil, surfaces, materials or compartments to be protected against fungi or attack insects) in an effective amount.
    [0114] This can be achieved by applying compound I and compound II simultaneously, either together (for example as a tank mix) or separately or successively, with the time interval between individual applications being selected to ensure that the active substance applied first still occurs at the site of action in a sufficient amount at the time of application of the other active substances. The order of application is not fundamental to the present invention.
    [0115] In the mixtures of the present invention, the weight ratio of the compounds in general depends on the properties of the compounds of the inventive mixtures.
    [0116] The compounds of the inventive mixtures can be used individually or already partially or completely mixed together to prepare the composition according to the invention. It is also possible for them to be packaged and used as a combination composition as well as a kit of elements.
    Petition 870170089690, of 11/21/2017, p. 42/69
    [0117] In one embodiment of the invention, kits can include one or more, including all, components that can be used to prepare a target agrochemical composition. For example, kits can include compound I and compound II and / or an adjuvant component and / or another pesticidal compound (for example insecticide or herbicide) and / or a growth-regulating component). One or more of the components can now be combined together or pre-formulated. In those combinations where more than two components are provided in a kit, the components can now be combined together and as such are packaged in a single container such as a bottle, bottle, can, bag, pouch or can. In other embodiments, two or more components of a kit can be separately packaged, i. and. not preformulated. As such, kits can include one or more separate containers such as flasks, cans, bottles, tote bags, bags or cans, each container containing a separate component for an agrochemical composition. In both forms, a component of the kit can be applied separately from or together with the other components or as a component of a combination composition according to the invention for the preparation of the composition according to the invention.
    [0118] The user applies the composition according to the invention in general from a metering device, a back atomizer, an atomization tank or an atomization plane. In this case, the agrochemical composition is prepared with water and / or buffer to the desired concentration of application, making it possible, if necessary, to add other auxiliaries and obtain the ready-to-use atomization liquor or the agrochemical composition according to the invention. Usually, 50 to 500 liters of the ready-to-use atomization liquor are applied per hectare of useful agricultural area, preferably 100 to 400 liters.
    Petition 870170089690, of 11/21/2017, p. 43/69
    34/56 [0119] According to one embodiment, individual compounds of the inventive mixtures formulated as a composition (or formulation) such as parts of a kit or parts of the inventive mixture can be mixed by the user himself in an atomization tank and other auxiliaries can be added if necessary (tank mix).
    [0120] In another embodiment, other individual compounds of the inventive mixtures formulated as a composition or partially pre-mixed components, for example components comprising compound I and compound II, can be mixed by the user in a mixing tank and other auxiliaries can be mixed. added if necessary (tank mix).
    [0121] In another embodiment, whether individual components of the composition according to the invention are partially premixed components, for example components comprising compound I and compound II, can be applied together (for example after tank mixing) or consecutively.
    [0122] As stated above, the present invention comprises a method for controlling animal pests, particularly arthropod pests, especially arthropod pests of the insect group, the pest, its habitat, breeding sites, its locus or the plants to be protected against pest attack, the soil or plant propagating material (preferably seed) is treated with an effective amount of pesticide from a mixture.
    [0123] The method of the invention does not include methods for the therapeutic treatment of the human body or animal body.
    [0124] The inventive mixtures show an extraordinary action against animal pests, coming from the following orders:
    Petition 870170089690, of 11/21/2017, p. 44/69
    35/56 insects of the order of lepidopteroids (Lepidoptera), for example Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarsia gemmatalis, Argyresthia conjugella, Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatoistura chumaoristone, Chimaoristone, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphania nitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Helolithis, Grapholitha funebranoth, Helolisis, Grapholitha funebrana, Helolis , Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exigua, Leucoptera coffeella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege sticticalia, Lymantricia, Lymantricia, Lymantria, Lymantriapseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Plathypena scabra, Plutella xylostella, Pseudoobylia, Friaga, tropica, Fruta, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni and Zeiraphera canadensis, beetles (Coleoptera), for example Agrilus sinuatus, Agriotes lineatus, Agriotes obscurus, Amphimallus solstitialis, Anisandusus, Antisandrus, Thomson, haemorrhoidalis, Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchus rufimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchusiocerisisisisisisisisisisisisisisisisis, Ceuthoris asparagi, Ctenicera ssp., Diabrotica longicornis, DiaPetição 870170089690, of 11/21/2017, p. 45/69
    36/56 brotica semipunctata, Diabrotica 12-punctata Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, Hylobius abietis, Hypera brunneipus, Hypera postica, Ips typographus, Limma, Lema bilinin, Lema bilinin oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha, Oulema oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysopath, Phyllotreta chrysopepyll, Phyllotreta chrysopepyll and Sitophilus granaria, flies, mosquitoes (Diptera), for example Aedes aegypti, Aedes albopictus, Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosyr, Anopheles leucosyr, Anopheles leucosyr saw cina, Ceratitis capitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghicola Cordylobia anthropophaga, Culicoides furens, Culexciaisis Culex, Culex, Culex pipis, Culex, melanura, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Fannia canicularis, Geomyza Tripunctata, Gasterophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fuscipes, Glossina fuscipes Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola oestris, Musca domestica, Musca, florum,
    Petition 870170089690, of 11/21/2017, p. 46/69
    37/56
    Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Rhagoletis pomonella, Sarcophagahem, Sarcophagaem han. bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula oleracea, and Tipula paludosa thrips (Thysanoptera), for example Dichromothrips corbetti, Dichromothrips ssp, Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Thrirtipsy and Thrirtipsy citri tabaci, termites (Isoptera), for example Calotermes flavicollis, Leucotermes flavipes, Heterotermes aureus, Reticulitermes flavipes, Reticulitermes virginicus, Reticulitermes lucifugus, Termes natalensis, and Coptotermes formosanus, cockroaches (Blattaria - Blattodella, Blattodella, german, for example, Blattodella, german, for example) American, Japanese Periplaneta, Periplan eta brunnea, Periplaneta fuligginosa, Periplaneta australasiae, and Blatta orientalis, aphids (Hemiptera), for example Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integrice, Lychee, impotent, Epsychist, Nezara viridula, Piesma quadrata, Solubea insularis, Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri, Aphis schneideri, Aphis schneideri, Aphis schneideri , Bemisia argentifolii, Brachycaudus cardui, Brachycaudus helichrysi, persicae Brachycaudus, prunicola Brachycaudus, Brevicoryne brassicae, Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, ribis Cryptomyzus, nordmannianae Dreyfusia, piceae Dreyfusia, Dysaphis radicola, Dysaulacorthum pseudosolani, plantaginea, Dysaphis, Dysaphis pyri, EmPetição 870170089690, of 11/21/2017, p. 47/69
    38/56 poasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Myzus persicae, Myzus ascalonici, Nezusasisisis, Myzus ceranisis, Myzus ceranisis Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mali, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphia inserti, Sappaphis atri, Sappaphis mali, Sappaphis mali, Sappaphis mali, Sappaphis mali, , Cimex lectularius, Cimex hemipterus, Reduvius senilis, Triatoma spp., And Arilus critatus.
    ants, bees, wasps, hornets (Hymenoptera), e.g. Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster spp., Hoplocampa minuta, Hoplocampa testudinea, Monom Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, Pheidole megacephala, Dasymutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, Paravespula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Wasp crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, crickets, locusts, locusts (Orthoptera), gratia, gratia, for example Achotal , Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris septemfasciata, American schistocerca, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, pariensus, angonoids, Hierogera,
    Petition 870170089690, of 11/21/2017, p. 48/69
    39/56
    Arachnids, such as arachnids (Acarina), for example from the families Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus, Boophilus decoloratus, Boophilus Derolor, Derophylentis andplus, , Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Ornithodorus turicata, Ornithonyssus bacoti, Otobius megnini, Rheismyspus, Dermanysusususpus, Riphyspus, Hermyspus scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyllocoptrata oleivora and Eriophyes sheldoni; Tarsonemidae spp. such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetranychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius and Tetranychus urticae, Panonychus ulmi, Panonychus citri, and Oligonychus pratensis; Araneida, for example Latrodectus mactans, and Loxosceles reclusa, fleas (Siphonaptera), for example Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Pulex irritans, Tunga penetrans, and Nosopsyllus fasciatus, moth, Firebratobia, Thysan domestica, centipedes (Chilopoda), for example Scutigera coleoptrata, millipedes (Diplopoda), for example Narceus spp., small centipedes Earwigs (Dermaptera), for example auricularia, lice (Phthiraptera), for example Pediculus humanus capitis, Pediculus human, pediculus human Pthirus pubis, Haematopinus eurysternus, Hae Petition 870170089690, of 11/21/2017, p. 49/69
    40/56 matopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus, parasitic nematodes of plants such as gall nematodes, Meloidogyne arenaria, Meloidogyne chitwoodi, Meloidogyne exigua, Meloidogyneneognápla Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other species of Globodera, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; nematode species; Anguina; stem and leaf nematodes, Aphelenchoides besseyi, Aphelenchoides fragariae, Aphelenchoides ritzemabosi and other species of Aphelenchoides; stinger nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine nematodes, Bursaphelenchus xylophilus and other species of Bursaphelenchus; annular nematodes, Criconema species, Criconemella species, Criconemoides species, and Mesocriconema species; stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species; perforating nematodes, Dolichodorus species; spiral nematodes, Helicotylenchus dihystera, Helicotylenchus multicinctus and other species Helicotylenchus, Rotylenchus robustus and other Rotylenchus species; sheathed nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; lance nematodes, Hoplolaimus columbus, Hoplolaimus galeatus and other Hoplolaimus species; false gall nematodes, Nacobbus aberrans and other Nacobbus species; needle-type nematodes, Longidorus elongates and other Longidorus species; pin nematodes, Paratylenchus species; lesion nematodes, Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and others
    Petition 870170089690, of 11/21/2017, p. 50/69
    41/56
    Pratylenchus species; Radinaphelenchus cocophilus and other Radinaphelenchus species; cavernicle nematodes, Radopholus similis and other Radopholus species; reniform nematodes, Rotylenchulus reniformis and other Rotylenchulus species; Scutellonema species; thick root nematodes, Trichodorus primitivus and other Trichodorus species; Paratrichodorus minor and other Paratrichodorus species; stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species and Merlinius species; nematodes of citrus, Tylenchulus semipenetrans and other Tylenchulus species; dagger nematodes, Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xiphinema species; and other species of plant parasitic nematodes.
    [0125] The mixtures, according to the invention, can be applied to any and all stages of pest development, such as eggs, larvae, pupa, and adults. Pests can be controlled by contacting the target pest, its food source, habitat, breeding sites and its locus with an effective amount as a pesticide of the inventive mixtures or of compositions comprising the mixtures.
    [0126] Locus means a plant, plant propagating material (preferably seed), soil, area, material or environment in which a pest develops or can grow.
    [0127] In general, effective amount as a pesticide means the amount of the inventive mixtures or compositions comprising the mixtures necessary to obtain an observable effect on growth, including the effects of necrosis, death, retardation, impediment and removal, destruction, or any other decrease in the occurrence and activity of the animal pest. The effective amount as a pesticide may vary for the various mixtures / compositions used in the invention. An effective pesticide amount of mixtures / compositions may also vary according to conditions
    Petition 870170089690, of 11/21/2017, p. 51/69
    42/56 predominant factors such as desired pesticidal effect and duration, climatic conditions, target species, locus, method of application and the like.
    [0128] As mentioned above, the present invention comprises a method for improving plant health, the plant being the locus where the plant grows or is expected to grow or plant propagating material, from which the plant grows, is treated with an effective amount for plant health of an inventive mix.
    [0129] The term effective amount for plant health means an amount of the inventive mixtures, which is sufficient to obtain plant health effects as defined below. More information is provided below as an example on quantity, routes of application and appropriate reasons to be used. In any case, the person skilled in the art is well aware of the fact that such an amount can vary within a wide range and depends on several factors, for example the treated cultivated plant or material and the climatic conditions.
    [0130] The term "effective amount" includes the terms "effective amount for plant health" and / or "effective amount as a pesticide" depending on the case.
    [0131] When preparing the mixtures, pure active compounds are preferably employed, to which other active compounds may be added, such as insecticides, herbicides, fungicides or active herbicidal compounds or growth regulators or fertilizers, according to the need.
    [0132] The inventive mixtures are used in the treatment of animal or plant pests, plant propagating material (preferably seeds), materials or soil to be protected against pest attack with an effective amount as a pesticide of the active compounds. The application can be done both before and after the infestation of the materials,
    Petition 870170089690, of 11/21/2017, p. 52/69
    43/56 plants or plant propagating material (preferably seeds) by pests.
    [0133] Preferably, the inventive mixtures are employed by treating animal or plant pests or the soil to be protected against pest attack through foliar application with an effective amount as a pesticide of the active compounds. Also in this case, the application can be done both before and after the infection of splantas by pests.
    [0134] In the method of fighting animal pests (insects, mites or nematodes) depending on the type of compound and the desired effect, the application rates of the mixtures according to the invention are 1 X 10 -5 g / m 2 a 1 g / m 2 (0.1 g / ha at 10,000 g / ha), preferably 1 X 10 -4 g / m 2 at 0.5 g / m 2 (1 g / ha at 5000 g / ha), more preferably from 2 X 10 -3 g / m 2 to 0.1 g / m 2 (20 g / ha to 1000 g / ha), most preferably from 1 X 10 -3 g / m 2 to 7.5 X 10 -2 g / m 2 (10 g / ha to 750 g / ha), particularly from 2 X 10 -3 g / m 2 to 5 X 10 -2 g / m 2 (20 g / ha to 500 g / ha) .
    [0135] In the context of the present invention, the term plant refers to an entire plant, a part of the plant or plant propagating material.
    [0136] Plants as well as the propagation material of said plants, which can be treated with the inventive mixtures include all genetically modified plants or transgenic plants, for example cultures that tolerate the action of herbicides or fungicides or insecticides due to improvement, including genetic engineering methods, or plants that have modified characteristics compared to existing plants that can be generated for example through traditional breeding methods and / or mutant generation or through recombinant procedures.
    Petition 870170089690, of 11/21/2017, p. 53/69
    44/56 [0137] For example, mixtures according to the present invention can be applied (as seed treatment, spray treatment, furrows or any other means) also to plants that have been modified by breeding, mutagenesis or genetic engineering including, but not limited to, agricultural biotechnology products on the market or in development (cf. http://www.bio.org/speeches/pubs/er/agri_products.asp). Genetically modified plants are plants, whose genetic material has been modified in such a way by the use of recombinant DNA technique that under natural circumstances they cannot be readily obtained through crossing, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include, but are not limited to, modification of the desired post-trans-national protein (s), oligo- or polypeptides for example by glycosylation or additions of polymers such as prenylated, acetylated or farnesylated moieties or PEG moieties.
    [0138] Plants that have been modified by breeding, mutagenesis or genetic engineering, for example, have been made tolerant to applications of specific classes of herbicides, such as hydroxyphenylpyruvate dioxigenase (HPPD); acetolactate synthase (ALS) inhibitors, such as sulfonyl urea (see for example US patent documents 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO 98/02526, WO 98/02527, WO 04 / 106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073) or imidazolinones (see for example US patent documents 6,222,100, WO 01/82685, WO 00/026390, WO 97/41218, WO 98/002526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/014357, WO 03/13225, WO 03/14356, WO 04/16073); enolpyruvylshikimato-3-phosphate synthase (EPSPS) inhibitors, such as glyphosate (see for
    Petition 870170089690, of 11/21/2017, p. 54/69
    45/56 example WO 92/00377); glutamine synthase (GS) inhibitors, such as glufosinate (see for example EP-A 242 236, EP-A 242 246) or oxynyl herbicides (see for example US patent document 5,559,024) as a result of conventional breeding methods or genetic engineering. Several cultivated plants have been made tolerant to herbicides by conventional breeding methods (mutagenesis), for example Clearfield® summer rape (Canola, BASF SE, Germany) which is tolerant to imidazolinones, for example imazamox. Genetic engineering methods have been used to make cultivated plants such as soybeans, cotton, beets and rapeseed tolerant to herbicides such as glyphosate and glufosinate, some of which are commercially available under the trade names RoundupReady® (glyphosate-tolerant, Monsanto, USA) and LibertyLink® (glufosinate-tolerant, Bayer CropScience, Germany).
    [0139] In addition, plants are also coated, which through the use of recombinant DNA technique are able to synthesize one or more insecticidal proteins, especially those known from the bacterial genus Bacillus, particularly Bacillus thuríngiensis, such as δendotoxins, by example CryIA (b), CryIA (c), CryIF, CryIF (a2), CryIIA (b), CryIIIA, CryIIIB (b1) or Cry9c; vegetative insecticidal proteins (VIP), for example VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins from nematode colonizing bacteria, for example Photorhabdus spp. or Xenorhabdus spp .; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins or other insect-specific neurotoxins; toxins produced by fungi, such as streptomycete toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome inactivating proteins (RIP), such as ricin, yellow corn RIP, abrina, lufina, saporina or briodina; enPetição 870170089690, of 11/21/2017, p. 55/69
    46/56 steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdiesteroid-IDP-glycosyl transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as sodium or calcium channel blockers; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilben synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention, these insecticidal proteins or toxins are to be understood expressly as pre-toxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains, (see, for example WO 02/015701). Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are described, for example, in patent documents EP-A 374 753, WO 93/007278, WO 95/34656, EP-A 427 529, EP-A 451 878 , WO 03/18810 and WO 03/52073. The methods of producing such genetically modified plants are generally known to the person skilled in the art and are described, for example in the publications referred to above. These insecticidal proteins contained in genetically modified plants give plants that produce these proteins tolerance to harmful pests derived from all taxonomic groups of arthropods, especially beetles (Coeloptera), dipterous insects (Diptera), and moths (Lepidoptera) and nematodes ( Nematoda). Genetically modified plants capable of synthesizing one or more insecticidal proteins are, for example, described in the publications referred to above, and some of them are commercially available such as YieldGard® (corn cultivars that produce the Cry1Ab toxin), YieldGard® Plus (corn cultivars) which produce the toxins Cry1Ab and Cry3Bb1), Starlink® (corn cultivars that produce the Cry9c toxin), Herculex® RW (corn cultivars that produce Cry34Ab1, Cry35Ab1 and the enzyme phosphinothricin-N-Acetyltransferase [PAT]); NuCOTN® 33B (cotton cultivars that produce the Cry1Ac toxin), Bollgard®
    Petition 870170089690, of 11/21/2017, p. 56/69
    47/56
    I (cotton cultivars that produce the CrylAc toxin), Bollgard® II (cotton cultivars that produce the Cry1Ac and Cry2Ab2 toxins); VIPCOT® (cotton cultivars that produce the VIP toxin); NewLeaf® (potato cultivars that produce the Cry3A toxin); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Bt11 (for example Agrisure® CB) and Bt176 from Syngenta seeds SAS, France, (corn cultivars that produce the Cry1Ab toxin and PAT enzyme), MIR604 from Syngenta seeds SAS, France (maize cultivars that produce a modified version of the Cry3A toxin, cf WO 03/018810), MON 863 from Monsanto Europe SA, Belgium (maize cultivars that produce the Cry3Bb1 toxin), IPC 531 from Monsanto Europe SA , Belgium (cotton cultivars that produce a modified version of the Cry1Ac toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivars that produce the Cry1 F toxin and the PAT enzyme).
    [0140] In addition, plants are also coated that by using recombinant DNA techniques are able to synthesize one or more proteins to increase the resistance or tolerance of those plants in relation to bacterial, viral or fungal pathogens. Examples of such proteins are the so-called “pathogenesis-related proteins” (PR proteins, see, for example EP-A 392 225), plant disease resistance genes (for example, potato cultivars, which express resistance genes that act against Phytophthora infestans derived from the Mexican wild potato Solanum bulbocastanum) or T4-lysozym (for example, potato cultivars capable of synthesizing these proteins with increased resistance against bacteria such as Erwinia amylvora). The methods of producing such genetically modified plants are generally known to the person skilled in the art and are described, for example in the publications referred to above.
    [0141] In addition, plants are also coated that by the use of recombinant DNA techniques are able to synthesize one or more proPetition 870170089690, of 11/21/2017, p. 57/69
    48/56 theines to increase productivity (eg biomass production, grain yield, starch content, oil content or protein content), drought tolerance, salinity or other growth-limiting environmental facts or tolerance to pests and fungi , bacterial or viral pathogens from those plants.
    [0142] In addition, plants are also coated which by the use of recombinant DNA technique contains a modified amount of content substances or new content substances, specifically to improve human or animal nutrition, for example oil cultures that produce fatty acids omega-3 long-chain health promoters or unsaturated omega-9 fatty acids (eg Nexera® rape, DOW Agro Sciences, Canada).
    [0143] In addition, plants are also coated, which by the use of recombinant DNA techniques contains a modified amount of content substances, specifically to improve the production of raw materials, for example potatoes that produce increased amounts of amylopectin (for example Amflora ® potato, BASF SE, Germany).
    [0144] The inventive mixtures are effective both by contact (via soil, glass, wall, bed net, carpet, plant parts or insect parts), as well as by ingestion (baits, or plant part) and through tropalaxies and transfer.
    [0145] Preferred application methods are in bodies of water, via soil, cracks and fissures, pastures, manure piles, sewers, in water, on floors, walls or perimeter spraying and baits.
    [0146] According to another preferred embodiment of the invention, for use against non-phytopathogenic pests such as ants, termites, wasps, flies, mosquitoes, crickets, locusts, or cockroaches the inventive mixtures are prepared in a bait-like preparation.
    Petition 870170089690, of 11/21/2017, p. 58/69
    49/56 [0147] The bait can be a liquid, solid or semi-solid preparation (for example a gel). The bait used in the composition is a product that is attractive enough to incite insects such as ants, termites, wasps, flies, mosquitoes, crickets etc. or cockroaches to eat them. This attraction can be selected from food stimulants or parahormones and / or sex hormones readily known in the prior art.
    [0148] Methods for controlling infectious diseases transmitted by non-phytopathogenic insects (eg malaria, dengue and yellow fever, lymphatic filariasis, and leishmaniasis) with the inventive mixtures and their respective compositions also comprise hut and home treatment surfaces, spraying aerial and impregnation of curtains, tents, clothing items, bed nets, tsetse fly bait or similar. Insecticidal compositions for application to fibers, fabric, knitwear, nonwovens, mesh material or sheets and tarpaulins, preferably comprise a composition that includes the inventive mixtures, optionally a repellent and at least one binder.
    [0149] Inventive mixtures and the compositions that comprise them can be used to protect wooden materials such as trees, fences, bed cabins etc. and constructions such as houses, annexes, factories, but also building materials, furniture and utensils, leather, fibers, vinyl articles, electrical wires and cables etc. against ants and / or termites and to combat ants and termites by preventing their harmful action on crops or people (for example when pests invade houses and public facilities).
    [0150] In the case of soil treatment or application on pest dwelling sites or nests, the amount of active substance varies from 0.0001 to 500 g per 100 m2, preferably from 0.001 to 20 g per 100 m2.
    Petition 870170089690, of 11/21/2017, p. 59/69
    50/56 [0151] Usual rates of application in the protection of materials are, for example, from 0.01 g to 1000 g of active compound per m2 of treated material, desirably from 0.1 g to 50 g per m2.
    [0152] Insecticidal compositions for use in the impregnation of materials typically contain from 0.001 to 95% by weight, preferably from 0.1 to 45% by weight, and more preferably from 1 to 25% by weight of at least one repellent and / or insecticide.
    [0153] For use in bait compositions, the typical active substance content is 0.0001% by weight to 15% by weight, desirably 0.001% by weight to 5% by weight of active compound. The composition used can also comprise other additives such as a solvent for the active material, a flavoring agent, a preservative, a dye or a bitter agent. Its attractiveness can also be increased through a special color, shape or texture.
    [0154] For use in atomizable compositions, the mixture content of the active substances is from 0.001 to 80% by weight, preferably from 0.01 to 50% by weight and most preferably from 0.01 to 15% by weight.
    [0155] As mentioned at the beginning, in a preferred embodiment of the invention, inventive mixtures are used for the protection of the seed and the sowing roots and sprouts, preferably the seeds.
    [0156] Seed treatment can be done in the seed box before planting in the field.
    [0157] For seed treatment purposes, the weight ratio in inventive mixtures in general depends on the properties of the compounds in the inventive mixtures.
    [0158] Common formulations, which are especially useful for seed treatment are for example:
    Petition 870170089690, of 11/21/2017, p. 60/69
    51/56
    Soluble concentrates (SL, LS)
    Demulsions (EW, EO, ES)
    ESuspensôes (SC, OD, FS)
    F Water-dispersible granules and water-soluble granules (WG, SG)
    G Water-dispersible powders and water-soluble powders (WP, SP,
    WS)
    Gel Formulations (GF)
    I Dustable powders (DP, DS) [0159] These compositions can be applied to plant propagating material, particularly seeds, diluted or undiluted. These compositions can be applied to plant propagating material, particularly to seeds, diluted or undiluted. The compositions in question produce, after dilution of two to ten times, concentrations of active substance from 0.01 to 60% by weight, preferably from 0.1 to 40% by weight, in ready-to-use preparations. The application can be carried out before or during sowing.
    [0160] Methods for applying the inventive mixture and compositions thereof, respectively in plant propagation material, especially seeds, are known in the art and include, but are not limited to, seed treatment, seed coating, seed sprinkling, impregnation seed, seed film coating, multilayer seed coating, seed encrustation, seed drip and seed pelleting.
    [0161] In a preferred embodiment, the compounds or compositions thereof, respectively, are applied to the plant propagation material through a method in such a way that germination is not inducedPetition 870170089690, of 11/21/2017, p. 61/69
    52/56 tion, for example by seed coating, pelletizing, coating and dusting.
    [0162] In the treatment of plant propagation material (preferably seed), the application rates of the inventive mixture in general are for the formulated product (which usually comprises from 10 to 750 g / l of the additives).
    [0163] The invention also relates to the propagation of plant products and especially to the seed comprising, that is, coated with and / or containing, a mixture as defined above or a composition (common formulation) comprising the inventive mixture of two or more active substances or a mixture of two or more compositions each providing one of the active substances. The plant propagation material (preferably seed) comprises the inventive mixtures in an amount of 0.1 g to 10 kg per 100 kg of plant propagation material (preferably seed), preferably 0.1 g to 1 kg per 100 kg of material plant propagation (preferably seed).
    [0164] The separate and joint application of the compounds of the inventive mixtures is done by atomizing or sprinkling the seeds, seedlings, plants or soil before or after sowing the plants or before or after emergence of the plants.
    [0165] According to a variant of soil application, another object of the invention being treated in furrows, which comprises the addition of a solid or liquid formulation comprising the inventive mixtures to the open furrow, in which seeds were sown or, alternatively, application of seeds and formulation simultanemanet to the open furrow.
    [0166] The mixtures of the present invention show synergistic action against the animal pests to be controlled. Synergism can be described as an interaction where the combined effect of a mixture of two or
    Petition 870170089690, of 11/21/2017, p. 62/69
    53/56 more compounds is greater than the sum of the individual effects of each of the compounds. The presence of a synergistic effect, in terms of percent control between two mixing components (X and Y) can be calculated using Colby's equation (Colby, SR, 1967, Calculating Synergistic and Antagonistic Responses in Herbicide Combinations, Weeds, 15, 20-22):
    E = X + Y ~ - [0167] ioo [0168] In Colby's formula X and Y are the control in% observed for the individual compounds at a given concentration. And it is the combined control effect that would be expected in the absence of synergism, if the compounds are applied together at the same concentrations of soil application. When the observed control effect for the mixture (i.e. the observed combined control effect) is greater than the expected combined control effect (E) as calculated from Colby's formula, then the observed effect will be synergistic.
    [0169] The following tests demonstrate the effectiveness of controlling the compounds, mixtures or compositions of this invention in specific pests. The pest control protection provided by compounds, mixtures or compositions is not limited to these species. In certain cases, combinations of a compound of this invention with other invertebrate pest control compounds or agent exhibited synergistic effects against certain important invertebrate pests.
    [0170] The analysis of synergism or antagonism between mixtures or compositions was determined using the Colby equation.
    Test 1: Control of vet aphids [0171] For the control of assessment of vet aphids (Megoura viciae) through contact or systemic means, the test was carried out in a test unit consisting of 24-well microtiter plates containing leaf discs of large beans.
    Petition 870170089690, of 11/21/2017, p. 63/69
    54/56 [0172] The individual compounds were formulated as a concentrated solution containing 75% v / v water and 25% v / v dimethyl sulfoxide (DMSO). The concentrated solutions were diluted with water to the desired concentrations of the compounds or mixtures and the dilutions were atomized over the 2.5pl sheet discs, using a customized microatomizer in two replications. For experimental mixtures in these tests, identical volumes of both mixing components at the desired concentrations respectively, were mixed together.
    [0173] After application, the leaf discs were air dried and 5-8 aphids were placed on the leaf discs inside the microtiter plate wells. The aphids were then allowed to aspirate over the treated leaf discs and incubated at 23 + 1 ° C, 50 + 5% RH for 5 days. Aphid mortality and fertility were then analyzed visually.
    As for the tested mixture, the results are listed in the table
    1.
    Table 1: Vet Aphid Control
    Concentration[pm] observed control mean [%] Calculated control[%} Compound I 0.004 25 - Bifenthrin 2 0 - Bifenthrin + Compound I 2 + 0.004 100 * 25
    * synergistic control effect according to Colby equation Test 2: Peach Green Aphid Control [0174] For the control of the evaluation of green peach aphids (Myzus persicae) using systemic means, the test unit consisted of 96 well microtiter containing liquid artificial diet under an artificial memb.
    Petition 870170089690, of 11/21/2017, p. 64/69
    55/56 [0175] The artificial compounds were formulated as a concentrated solution containing 75% v / v water and 25% v / v dimethyl sulfoxide (DMSO). The concentrated solutions were diluted with water in the desired concentrations of the compounds or mixtures and the dilutions were pipetted into the aphid's diet, using a pipettor, in two replications. For experimental mixtures in these tests, equal volumes of both mixing components at the desired concentrations respectively were mixed together.
    [0176] After application, 5 - 8 adult aphids were placed on the artificial membrane inside the microtiter plate wells. The aphids were then allowed to aspirate over the treated aphid diet and incubated at 23 + 1 ° C, 50 + 5% RH for 3 days. Aphid mortality and fertility were then visually analyzed. For the tested mixture, the results are listed in Table 2.
    Table 2: Control of green peach aphids
    Concentration[pm] observed control mean [%] Calculated control [%} Compound I 0.004 0 - Abamectin 0.016 0 - Abamectin + Compound I 0.016 + 0.004 75 * 0 Bifenthrin 0.08 0 - Bifenthrin + Compound I 0.08 + 0.004 100 * 0
    * synergistic control effect according to Colby's equation Test 3: Cotton Boll weed control [0177] For the evaluation of cotton boll weevil (Anthonomus grandis) the test unit consisted of 24 well microtiter plates containing one insect diet and 20-30 A. grandis eggs.
    Petition 870170089690, of 11/21/2017, p. 65/69
    56/56 [0178] The individual compounds were formulated as a concentrated solution containing 75% v / v water and 25% v / v dimethyl sulfoxide (DMSO). The concentrated solutions were diluted with water in the desired concentrations of the compounds or mixtures and the dilutions were atomized over the insect diet in 20 pl, using a personalized microatomizer in two replications. For experimental mixtures in these tests equal volumes of both mixing components at the desired concentrations respectively, were mixed together.
    [0179] After application, microtiter plates were incubated at 23 + 1 ° C, 50 + 5% RH for 5 days. The mortality of eggs and larvae was then analyzed. As for the tested mixture, the results are listed in Table 3.
    Table 3: Cotton Beak Control
    Concentration[pm] Control averageobserved [%] Calculated control[%} Compound I 0.02 0 - Compound M26.4 2 0 - Compound M26.4 + Compound I 2 + 0.02 50 * 0
    * synergistic control effect according to Colby's equation [0180] Compound M26.4: 4 - {[(6-chloropyrid-3-yl) methyl] (2fluoroethyl) amino} furan-2 (5H) -one
    Petition 870170089690, of 11/21/2017, p. 66/69
    1/2
    权利要求:
    Claims (9)
    [1]
    Claims
    1. SYNERGIC MIXTURES, characterized by the fact that they comprise:
    (1) the pesticidal compound of formula I:
    and a pesticidal compound II which is abamectin;
    where the weight ratio of compound I and compound II is 1: 500 to
    500: 1.
    [2]
    2. PESTICIDE COMPOSITION, characterized by the fact that it comprises a liquid or solid vehicle and a mixture, as defined in claim 1.
    [3]
    3. METHOD TO CONTROL ANIMAL PEST, characterized by the fact that the pest, its habitat, breeding sites, its locus or the plants to be protected against pest attack, the soil or plant propagation material are treated with a quantity of 1 X 10 -5 g / m 2 to 1 g / m 2 (0.1 g / ha to 10,000 g / ha) of a mixture, as defined in claim 1, wherein the method does not comprise treatment in the human body or animal.
    [4]
    4. METHOD according to claim 3, characterized in that it is additionally to improve the health of plants, in which the locus where the plant grows or is expected to grow or the plant propagation material from which the plant grows are treated.
    Petition 870170089690, of 11/21/2017, p. 67/69
    2/2
    [5]
    5. METHOD FOR PROTECTING PLANT PROPAGATION MATERIAL against animal pests, characterized by the fact that it comprises putting plant propagation materials in contact with a mixture, as defined in claim 1, in an amount of 0.01 g to 10 kg per 100 kg of plant propagation material.
    [6]
    6. METHOD according to any one of claims 3 to 5, characterized by the fact that the compounds, as defined in claim 1, are applied simultaneously, that is, jointly, separately, or successively.
    [7]
    7. METHOD, according to any of claims 3 to 6, characterized by the fact that the animal pests to be controlled, are selected from the group consisting of arthropod pests, and particularly insects.
    [8]
    8. USE OF A MIXTURE, as defined in claim 1, characterized by the fact that it is to control animal pests.
    [9]
    9. USE, according to claim 8, characterized by the fact that the animal pests to be controlled are selected from the group consisting of arthropod pests, and particularly insects.
    Petition 870170089690, of 11/21/2017, p. 68/69
    类似技术:
    公开号 | 公开日 | 专利标题
    JP5948320B2|2016-07-06|Pesticide mixture
    CN104206402B|2018-04-24|Pesticide combination comprising cyanosulfoximine compounds
    JP5877202B2|2016-03-02|Composition comprising a pyripyropene insecticide and a base
    DK2083629T4|2015-03-02|CRYSTAL MODIFICATION OF FIPRONIL
    US20090305886A1|2009-12-10|Pesticidal Mixtures
    JP2009523758A|2009-06-25|Pesticide mixture
    KR20080033380A|2008-04-16|Pesticidal mixtures comprising a phenylsemicarbazone
    KR20090108733A|2009-10-16|Pesticidal mixtures comprising phenylsemicarbazone and clothianidin
    KR20090081423A|2009-07-28|Crystalline modification of fipronil
    US20080261812A1|2008-10-23|Pesticidal Mixtures
    WO2008031712A2|2008-03-20|Pesticidal active mixtures comprising sulfonamides
    TW200838428A|2008-10-01|Pesticidally active compositions comprising 3-acetyl-1-phenylpyrazole compounds
    KR101847665B1|2018-04-10|Pesticidal composition comprising a benzoylurea compound and chlorfenapyr and their uses
    AU2014227475B2|2015-12-17|Pesticidal mixtures
    KR20140063757A|2014-05-27|Insecticidal active mixtures comprising arylquinazolinone compounds
    同族专利:
    公开号 | 公开日
    PE20130631A1|2013-05-29|
    KR101874132B1|2018-07-03|
    CL2012003180A1|2013-03-22|
    MX339218B|2016-05-17|
    TW201201696A|2012-01-16|
    AU2011257163A1|2012-12-13|
    EP2575471B1|2014-11-19|
    TW201717765A|2017-06-01|
    BR112012028881A2|2015-09-22|
    JP5948320B2|2016-07-06|
    TW201717764A|2017-06-01|
    AU2011257163B2|2014-07-24|
    CN102905528B|2015-07-22|
    TWI584733B|2017-06-01|
    ES2527246T3|2015-01-21|
    AR084692A1|2013-06-05|
    CR20120588A|2013-01-03|
    TWI587786B|2017-06-21|
    MX2012012831A|2012-11-30|
    US20130125267A1|2013-05-16|
    TWI584734B|2017-06-01|
    CN102905528A|2013-01-30|
    US9125416B2|2015-09-08|
    EP2575471A1|2013-04-10|
    JP2013527191A|2013-06-27|
    WO2011147952A1|2011-12-01|
    KR20130106288A|2013-09-27|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5304732A|1984-03-06|1994-04-19|Mgi Pharma, Inc.|Herbicide resistance in plants|
    BR8600161A|1985-01-18|1986-09-23|Plant Genetic Systems Nv|CHEMICAL GENE, HYBRID, INTERMEDIATE PLASMIDIO VECTORS, PROCESS TO CONTROL INSECTS IN AGRICULTURE OR HORTICULTURE, INSECTICIDE COMPOSITION, PROCESS TO TRANSFORM PLANT CELLS TO EXPRESS A PLANTINIDE TOXIN, PRODUCED BY CULTURES, UNITED BY BACILLA|
    ES2018274T5|1986-03-11|1996-12-16|Plant Genetic Systems Nv|VEGETABLE CELLS RESISTANT TO GLUTAMINE SYNTHETASE INHIBITORS, PREPARED BY GENETIC ENGINEERING.|
    FR2629098B1|1988-03-23|1990-08-10|Rhone Poulenc Agrochimie|CHEMICAL GENE OF HERBICIDE RESISTANCE|
    KR900003088B1|1988-03-26|1990-05-07|재단법인 한국화학연구소|5-hydroxy prazole derivatives|
    NZ231804A|1988-12-19|1993-03-26|Ciba Geigy Ag|Insecticidal toxin from leiurus quinquestriatus hebraeus|
    DE69034081T2|1989-03-24|2004-02-12|Syngenta Participations Ag|Disease resistant transgenic plant|
    EP0427529B1|1989-11-07|1995-04-19|Pioneer Hi-Bred International, Inc.|Larvicidal lectins and plant insect resistance based thereon|
    AU655197B2|1990-06-25|1994-12-08|Monsanto Technology Llc|Glyphosate tolerant plants|
    US5625136A|1991-10-04|1997-04-29|Ciba-Geigy Corporation|Synthetic DNA sequence having enhanced insecticidal activity in maize|
    US5530195A|1994-06-10|1996-06-25|Ciba-Geigy Corporation|Bacillus thuringiensis gene encoding a toxin active against insects|
    JP3725198B2|1995-03-27|2005-12-07|社団法人北里研究所|Pyripyropene derivative|
    JPH08269062A|1995-03-30|1996-10-15|Kitasato Inst:The|Pyripyropene derivative|
    US6406690B1|1995-04-17|2002-06-18|Minrav Industries Ltd.|Bacillus firmus CNCM I-1582 or Bacillus cereus CNCM I-1562 for controlling nematodes|
    DE19613334A1|1996-04-03|1997-10-09|Bayer Ag|Means for controlling parasitic insects and mites on humans|
    US5773704A|1996-04-29|1998-06-30|Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College|Herbicide resistant rice|
    US5773702A|1996-07-17|1998-06-30|Board Of Trustees Operating Michigan State University|Imidazolinone herbicide resistant sugar beet plants|
    CN1230217A|1996-07-17|1999-09-29|密执安州大学|Imidazolinone herbicide resistant sugar beet plants|
    US6348643B1|1998-10-29|2002-02-19|American Cyanamid Company|DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use|
    AU5920601A|2000-04-28|2001-11-12|American Cyanamid Co|Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots, maize, rice and wheat plants resistant to the imidazolinone herbicides|
    WO2002015701A2|2000-08-25|2002-02-28|Syngenta Participations Ag|Bacillus thuringiensis crystal protein hybrids|
    JP2003026510A|2001-05-09|2003-01-29|Sumitomo Chem Co Ltd|Malononitrile compound and its application to pest control|
    AU2002320377B8|2001-08-09|2008-09-04|Northwest Plant Breeding Company|Wheat plants having increased resistance to imidazolinone herbicides|
    AU2002319037B2|2001-08-09|2008-05-29|University Of Saskatchewan|Wheat plants having increased resistance to imidazolinone herbicides|
    UA89016C2|2001-08-09|2009-12-25|Юниверсити Оф Саскачеван|Wheat plant having increased resistance towards imidasolinone herbicides|
    US7230167B2|2001-08-31|2007-06-12|Syngenta Participations Ag|Modified Cry3A toxins and nucleic acid sequences coding therefor|
    WO2003052073A2|2001-12-17|2003-06-26|Syngenta Participations Ag|Novel corn event|
    EP2329708B1|2002-07-10|2016-10-19|The Department of Agriculture, Western Australia|Wheat plants having increased resistance to imidazolinone herbicides|
    CN100343233C|2002-07-17|2007-10-17|住友化学株式会社|Malononitrile compounds and their uses|
    KR100522446B1|2003-01-07|2005-10-18|한국생명공학연구원|AGENT FOR KILLING INSECTS COMPRISING COMPOUNDS HAVING ACYL CoA:CHOLESTEROL ACYLTRANSFERASE INHIBITORY OR SALT THEREOF|
    EP1633875B1|2003-05-28|2012-05-02|Basf Se|Wheat plants having increased tolerance to imidazolinone herbicides|
    AR047107A1|2003-08-29|2006-01-11|Inst Nac De Tecnologia Agropec|RICE PLANTS THAT HAVE A GREATER TOLERANCE TO IMIDAZOLINONA HERBICIDES|
    CA2547052C|2003-12-26|2011-03-29|Sumitomo Chemical Company, Limited|Nitrile compound and its use in pest control|
    AU2005205311B2|2004-01-16|2010-07-08|Sumitomo Chemical Company, Limited|Malononitrile compound as pesticides|
    RU2362769C2|2004-01-16|2009-07-27|Сумитомо Кемикал Компани, Лимитед|Malononitryl derivatives and their application|
    EA014881B1|2004-03-05|2011-02-28|Ниссан Кемикал Индастриз, Лтд.|Substitited alkylbenzene derivatives|
    JP2006131529A|2004-11-05|2006-05-25|Sumitomo Chemical Co Ltd|Pest control composition|
    US7491738B2|2005-06-01|2009-02-17|Meiji Seika Kaisha, Ltd.|Pest control agents|
    TWI388282B|2005-06-01|2013-03-11|Meiji Seika Pharma Co Ltd|Pest control agents|
    EP1932836B1|2005-09-02|2013-11-06|Nissan Chemical Industries, Ltd.|Isoxazoline-substituted benzamide compound and harmful organism-controlling agent|
    WO2007043677A1|2005-10-14|2007-04-19|Sumitomo Chemical Company, Limited|Hydrazide compound and pesticidal use of the same|
    WO2007060839A1|2005-11-22|2007-05-31|Sumitomo Chemical Company, Limited|Organic sulfur compounds and use thereof as arthropodicides|
    TWI412322B|2005-12-30|2013-10-21|Du Pont|Isoxazolines for controlling invertebrate pests|
    DE102006015197A1|2006-03-06|2007-09-13|Bayer Cropscience Ag|Active ingredient combination with insecticidal properties|
    DE102006015467A1|2006-03-31|2007-10-04|Bayer Cropscience Ag|New cyclic enamine ketone derivatives useful for controlling pests, especially insects|
    EP2107060B1|2006-11-30|2011-12-28|Meiji Seika Pharma Co., Ltd.|Pest control agent|
    JP5449669B2|2006-12-14|2014-03-19|石原産業株式会社|Pest control composition|
    JP2009001541A|2006-12-15|2009-01-08|Ishihara Sangyo Kaisha Ltd|Method for producing anthranilamide compound using new pyrazole compound as intermediate|
    US8859462B2|2007-03-08|2014-10-14|Meiji Seika Pharma Co., Ltd.|Pest control composition|
    US8263778B2|2007-08-13|2012-09-11|Meiji Seika Pharma Co., Ltd.|Process for producing pyripyropene derivatives and intermediates for the production thereof|
    WO2009051956A2|2007-10-16|2009-04-23|E. I. Du Pont De Nemours And Company|Pyrazole-substituted isoxazoline insecticides|
    KR20100094550A|2007-12-21|2010-08-26|메이지 세이카 가부시키가이샤|Novel systemic pesticide|
    TW201444787A|2008-04-09|2014-12-01|Du Pont|Method for preparing 3-trifluoromethyl chalcones|
    ES2567266T3|2010-05-28|2016-04-21|Basf Se|Pesticide mixtures|UY33887A|2011-02-03|2012-09-28|Syngenta Ltd|PEST CONTROL METHODS IN SOYA|
    US20130131091A1|2010-05-24|2013-05-23|Kimihiko Goto|Harmful organism control agent|
    ES2567266T3|2010-05-28|2016-04-21|Basf Se|Pesticide mixtures|
    CN110294765A|2010-09-14|2019-10-01|巴斯夫欧洲公司|Composition containing pyridine Nan Ping insecticide and auxiliary agent|
    AU2011303965B9|2010-09-14|2014-12-18|Basf Se|Composition containing a pyripyropene insecticide and a base|
    US8895587B2|2011-05-18|2014-11-25|Syngenta Participations Ag|Insecticidal compounds based on arylthioacetamide derivatives|
    UY34104A|2011-05-31|2013-01-03|Syngenta Participations Ag|? HETEROCYCLIC BENZAMID DERIVATIVE COMPOUNDS, PROCESSES AND INTERMEDIATES FOR PREPARATION, COMPOSITIONS AND METHODS FOR USE.|
    EP2748137A1|2011-08-22|2014-07-02|Syngenta Participations AG|Dihydrofuran derivatives as insecticidal compounds|
    WO2013026724A1|2011-08-22|2013-02-28|Syngenta Participations Ag|Dihydrofuran derivatives as insecticidal compounds|
    WO2013026695A1|2011-08-25|2013-02-28|Syngenta Participations Ag|Isoxazoline derivatives as insecticidal compounds|
    EP2747570B1|2011-08-25|2018-09-19|Syngenta Participations AG|Isoxazoline derivatives as insecticidal compounds|
    MX2014002092A|2011-08-25|2014-04-25|Syngenta Participations Ag|Isoxazoline derivatives as insecticidal compounds.|
    WO2013026929A1|2011-08-25|2013-02-28|Syngenta Participations Ag|Dihydropyrrole derivatives as insecticidal compounds|
    BR122018069466B1|2011-09-13|2019-04-02|Syngenta Participations Ag|ISOTIAZOLIN DERIVATIVES AS INSECTICATED COMPOUNDS|
    CN103842346A|2011-10-03|2014-06-04|先正达参股股份有限公司|Isoxazoline derivatives as insecticidal compounds|
    EP2825050B1|2012-03-12|2016-02-03|Basf Se|Liquid concentrate formulation containing a pyripyropene insecticide i|
    CN104168769B|2012-03-12|2016-12-14|巴斯夫欧洲公司|The method producing the aqueous suspension-concentrates preparaton of pyridine Nan Ping insecticide|
    BR112014022497B1|2012-03-12|2021-02-23|Basf Se|FORMULATION OF LIQUID CONCENTRATE, WATER PREPARATION, METHODS TO PARAPROTEGATE PLANTS OF ATTACKS OR INFESTATION BY INVERTEBRATE PAGGES, NON-THERAPEUTIC TO CONTROL INVERTEBRATED PAGES AND TO PROTECT MATERIAL DEPROPAGE FROM PLANTS AGAINST LARGE PLACES AND INVERTED PAGES.|
    WO2013135674A1|2012-03-12|2013-09-19|Syngenta Participations Ag|Insecticidal 2-aryl-acetamide compounds|
    CN103300035A|2012-03-14|2013-09-18|陕西韦尔奇作物保护有限公司|Pesticide composition containing chromafenozide|
    CN102657178B|2012-04-12|2013-11-06|广东中迅农科股份有限公司|Synergistic acaricidal composition containing spiromesifen and pyridaben|
    WO2014001120A1|2012-06-25|2014-01-03|Syngenta Participations Ag|Isothiazole derivatives as insecticidal compounds|
    WO2014001121A1|2012-06-25|2014-01-03|Syngenta Participations Ag|Isothiazole derivatives as insecticidal compounds|
    US9867375B2|2012-07-31|2018-01-16|Syngenta Participations Ag|Methods of pest control in soybean|
    CN104520287A|2012-08-03|2015-04-15|先正达参股股份有限公司|Methods of controlling insects|
    WO2014019950A1|2012-08-03|2014-02-06|Syngenta Participations Ag|Methods of pest control in soybean|
    BR112015001979A2|2012-08-03|2017-07-04|Syngenta Participations Ag|soybean pest control methods|
    WO2014029640A1|2012-08-24|2014-02-27|Syngenta Participations Ag|Methods of controlling insects|
    CN104582485A|2012-08-24|2015-04-29|先正达参股股份有限公司|Methods of soil pest control|
    WO2014029709A1|2012-08-24|2014-02-27|Syngenta Participations Ag|Methods of controlling insects|
    AR093342A1|2012-11-06|2015-06-03|Makhteshim Chem Works Ltd|MIX FOR PEST CONTROL|
    WO2014079935A1|2012-11-21|2014-05-30|Syngenta Participations Ag|Insecticidal compounds based on arylthioacetamide derivatives|
    ES2716379T3|2013-02-20|2019-06-12|Basf Se|Anthranilamide compounds, their mixtures and the use thereof as pesticides|
    WO2014131837A1|2013-02-28|2014-09-04|Syngenta Participations Ag|Isoxaline derivatives for use in cotton plants|
    EP2978316A1|2013-03-28|2016-02-03|Syngenta Participations AG|Methods of controlling neonicotinoid resistant pests|
    CA3134748A1|2013-10-18|2015-04-23|Basf Agrochemical Products B.V.|Agricultural mixtures comprising carboxamide compound|
    WO2015055752A1|2013-10-18|2015-04-23|Basf Se|Insecticidal active mixtures comprising carboxamide compound|
    CN103518733B|2013-10-24|2015-09-16|江苏龙灯化学有限公司|A kind of Pesticidal combination containing ethyl pleocidin and bromine cyanogen insect amide|
    CN103583553B|2013-11-21|2014-12-17|济南凯因生物科技有限公司|Water dispersible granule of theta-cypermethrin and pyriproxyfen and application of same|
    CN103583557B|2013-11-22|2015-07-15|山东中新科农生物科技有限公司|Composition for preventing tea lesser leafhoppers|
    CN103814937B|2014-02-11|2015-10-07|深圳诺普信农化股份有限公司|A kind of Pesticidal combination|
    CN103814909A|2014-02-11|2014-05-28|深圳诺普信农化股份有限公司|Synergistic pesticidal composition|
    CN104054736A|2014-06-30|2014-09-24|海利尔药业集团股份有限公司|Insecticidal combination containing sulfoxaflor and spirotetramat|
    WO2016038067A1|2014-09-10|2016-03-17|Basf Se|Use of afidopyropene in genetically modified plants|
    CN104365606B|2014-10-24|2015-12-02|青岛瀚生生物科技股份有限公司|Dihalo pyrazole amide and Tolfenpyrad complex insecticidal composition|
    CN109304350A|2016-05-12|2019-02-05|温州泓呈祥科技有限公司|The soil restoring device of organo-chlorine pesticide ingredient in a kind of removal agricultural land soil|
    CN106106500A|2016-06-24|2016-11-16|江苏省绿盾植保农药实验有限公司|A kind of containing double third ring worm esters and the composite insecticide of ethofenprox and application|
    CN106106501A|2016-06-27|2016-11-16|深圳诺普信农化股份有限公司|A kind of Synergistic insecticidal compositions containing double third ring worm esters|
    CN106165695A|2016-07-22|2016-11-30|深圳诺普信农化股份有限公司|A kind of Synergistic insecticidal compositions containing double third ring worm esters|
    CN106305762A|2016-08-24|2017-01-11|深圳诺普信农化股份有限公司|Synergistic insecticidal composite containing afidopyropen|
    CN106342843A|2016-08-27|2017-01-25|深圳诺普信农化股份有限公司|Insecticide composition containing haloxyfop furanone|
    CN106417348A|2016-10-10|2017-02-22|深圳诺普信农化股份有限公司|Afidopyropen-containing synergistic pesticidal composition|
    CN106538586B|2016-10-13|2018-10-23|深圳诺普信农化股份有限公司|A kind of Synergistic insecticidal compositions containing double third ring worm esters|
    CN106489981A|2016-10-17|2017-03-15|佛山市盈辉作物科学有限公司|Pesticidal combination containing afidopyropen and trifluoro-benzene pyrimidine|
    CN106489952A|2016-10-21|2017-03-15|佛山市盈辉作物科学有限公司|Pesticidal combination containing afidopyropen and nitrile pyrrole demodicid mite ester|
    CN106561689A|2016-11-15|2017-04-19|佛山市盈辉作物科学有限公司|Pesticide composition containing afidopyropen and cyclaniliprole|
    CN106561699A|2016-11-15|2017-04-19|佛山市盈辉作物科学有限公司|Composite containing Afidopyropen and SYP-9080|
    CN106538587A|2016-11-26|2017-03-29|佛山市普尔玛农化有限公司|Composition pesticide containing double third ring worm esters and Nylar|
    CN106538588A|2016-12-08|2017-03-29|深圳诺普信农化股份有限公司|A kind of Synergistic insecticidal compositions containing double third ring worm esters|
    CN106577700A|2016-12-14|2017-04-26|广东省农业科学院植物保护研究所|Medicine composition for controlling bemisia tabaci|
    CN106857620A|2017-02-26|2017-06-20|佛山市瑞生通科技有限公司|Composition pesticide containing double third ring worm esters and indoxacarb|
    CN106857636A|2017-03-13|2017-06-20|深圳诺普信农化股份有限公司|A kind of Synergistic insecticidal compositions containing double third ring worm esters|
    CN106857640A|2017-03-20|2017-06-20|陕西上格之路生物科学有限公司|A kind of Pesticidal combination containing double third ring worm esters|
    CN106962391A|2017-03-28|2017-07-21|陕西上格之路生物科学有限公司|A kind of Pesticidal combination containing double third ring worm esters|
    KR101953984B1|2017-08-01|2019-03-04|주식회사 팜한농|Compositions comprising Bistrifluron and Indoxacarb having Insecticidal Activities|
    AR113761A1|2017-10-18|2020-06-10|Syngenta Participations Ag|PEST CONTROL OF HEMIPTERS USING RNA MOLECULES|
    CN109845742A|2017-11-30|2019-06-07|佛山市盈辉作物科学有限公司|A kind of Pesticidal combination containing afidopyropen and spirodiclofen|
    US20200383333A1|2018-01-29|2020-12-10|BASF Agro B.V.|New agrochemical formulations|
    CN108967437A|2018-08-22|2018-12-11|中国农业大学|A kind of pair of the third ring worm ester and Acetamiprid compound synergic insecticide and its application|
    CN109221191A|2018-10-11|2019-01-18|泰安市农业科学研究院|Pesticidal combination and its application containing double third ring worm esters and pymetrozine|
    CN109392945B|2018-11-05|2020-11-20|中国农业大学|Compound pesticide for effectively preventing and controlling cotton aphids and application thereof|
    CN111328825A|2018-12-18|2020-06-26|燕化永乐（乐亭）生物科技有限公司|Insecticidal composition|
    CN111357758A|2018-12-26|2020-07-03|燕化永乐（乐亭）生物科技有限公司|Compound insecticide|
    CN111374144A|2018-12-27|2020-07-07|燕化永乐（乐亭）生物科技有限公司|Insecticidal composition|
    CN111406756A|2019-01-04|2020-07-14|燕化永乐（乐亭）生物科技有限公司|Compound insecticide|
    CN111713506A|2019-03-21|2020-09-29|燕化永乐（乐亭）生物科技有限公司|Insecticidal composition|
    CN109984142A|2019-05-17|2019-07-09|江西正邦作物保护有限公司|A kind of Pesticidal combination containing double third ring worm esters and shuangweiwei|
    CN110100838A|2019-06-20|2019-08-09|漯河市农业科学院|A kind of Pesticidal combination|
    CN110214786B|2019-06-28|2021-11-30|广西壮族自治区农业科学院|Ultralow-volume liquid containing dicyclopropyl succinate and sodium rosinate|
    CN110250188B|2019-07-04|2021-07-06|山东省农业科学院植物保护研究所|Medicament composition for preventing and treating bemisia tabaci and aphis cucumeriae|
    CN110495470A|2019-08-29|2019-11-26|上海明德立达生物科技有限公司|A kind of insecticide composition and its application|
    CN110637823A|2019-09-20|2020-01-03|上海明德立达生物科技有限公司|Pesticide composition and application thereof|
    CN110574763A|2019-10-10|2019-12-17|河北军星生物化工有限公司|Insecticidal composition|
    CN111011391A|2019-11-18|2020-04-17|青岛润生农化有限公司|Composite insecticidal composition and application thereof|
    CN110959627A|2019-11-18|2020-04-07|青岛东生药业有限公司|Pesticide composition and application thereof|
    法律状态:
    2017-08-22| B07A| Technical examination (opinion): publication of technical examination (opinion)|
    2017-09-19| B15K| Others concerning applications: alteration of classification|Ipc: A01N 43/90 (1980.01), A01N 43/40 (1980.01), A01N 5 |
    2018-02-06| B09A| Decision: intention to grant|
    2018-03-20| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/05/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US34922810P| true| 2010-05-28|2010-05-28|
    EP10164305.4|2010-05-28|
    EP10164305|2010-05-28|
    US61/349,228|2010-05-28|
    PCT/EP2011/058704|WO2011147952A1|2010-05-28|2011-05-27|Pesticidal mixtures|
    [返回顶部]