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    • 专利摘要:
    BAGS FOR A CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT INSTALLATION The invention relates to a bag comprising a first duct (13C) that extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (HM) that emerges on a second side (69); a second conduit (13B) extending longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging from said first side (68), and another tangential flow connector (11N) that emerges on said second side (69); a third conduit (13H) extending from a second side of said conduit (13C), starting from a collection container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) extending from the first side of said conduit (13C), starting from a transfer pump connector (11A), until it enters said second conduit (13B).
    公开号:BR112012027174B1
    申请号:R112012027174-1
    申请日:2011-06-20
    公开日:2020-10-27
    发明作者:Jean-Louis Weissenbach；Sébastien Cirou
    申请人:Emd Millipore Corporation；
    IPC主号:
    专利说明:

    [0001] The invention relates to a bag for the device of a biological liquid treatment facility, particularly, but not exclusively, to purify a biopharmaceutical liquid to obtain products, such as monoclonal antibodies, vaccines or recombinant proteins.
    [0002] The invention also relates to a device for a biological liquid treatment facility.
    [0003] It is well known that biopharmaceutical liquids are generally obtained by culture in a bioreactor and that they need to be treated to obtain the desired characteristics of purity, concentration, absence of viruses, etc.
    [0004] Purification is carried out by means of a succession of treatments, such as clarification, to eliminate culture residues in the bioreactor, and viral filtration, sometimes followed by diafiltration and concentration by means of tangential flow filtration (TFF, “ tangential flow filtration ”). There are other operations related to purification, such as chromatography (XMO).
    [0005] Purification treatments are performed substantially by means of filtration operations in a circuit that leads to a container to collect the treated liquid.
    [0006] Various types of containers containing liquids can be connected to the circuit input, such as the source container containing the product to be treated, but also containers containing a cleaning liquid, such as sodium hydroxide (NaOH), a liquid rinse, such as pure water for injections or a buffer liquid, such as saline. In addition to the container for collecting the treated liquid, several other containers for collecting cleaning, rinse, or tampon liquid, or for collecting waste, can be connected to the circuit outlet.
    [0007] In a production context, liquid treatments can be performed sequentially, with the collection container for the first treatment potentially becoming the source container for the next treatment, and so on until the last treatment be carried out.
    [0008] These treatments are conventionally carried out in dedicated facilities comprising stainless steel tubes and other parts, such as tanks or filter housings, which require operations before and after effective treatment, which are relatively expensive, in particular cleaning operations after use.
    [0009] In the last few years, these treatments have been carried out alternatively in installations where the components in contact with the liquid are single-use components.
    [0010] These single-use components have the advantage of avoiding cleaning operations, but to provide a required degree of safety, the implementation of an installation with these components requires selection, assembly and verification operations that are relatively complex.
    [0011] This is particularly the case when the number of tubes and other circuit components (connectors, valves, etc.) is high and / or when the operating pressure is high.
    [0012] According to a first aspect, the invention refers to providing a bag that allows the simple, economical and advantageous implementation of treatments for biological liquid.
    [0013] For this purpose, the invention relates to a bag for a circuit of an installation for the treatment of a biological liquid by means of tangential filtration, comprising: - a plurality of connectors and a network for transporting liquid between said connectors, being that said transport network is formed by a plurality of conduits; and - two flexible films attached to each other, said ducts being formed between the two flexible films; a first conduit that extends longitudinally between a flow pump connector that emerges on a first side of said bag and a tangential filter connector that emerges on a second side of said bag that is a side opposite to said first side; a second conduit extending longitudinally from a first side of said conduit between a connector of the supply container that emerges on said first side of said bag, and another tangential filter connector that emerges on said second side of said bag that is a side opposite to said first side; a third conduit extending from a second side of said conduit, which is a side opposite to said first side of said conduit, starting at a connector of the collection container, until it enters said first conduit; and a fourth conduit extending from the first side of said conduit, starting at a transfer pump connector, until it enters said second conduit; with which said bag is configured in such a way that the liquid to treat passes into said bag via said fourth conduit, then passes to a supply container via said second conduit, then passes to the tangential filter through the action of a pump flow through said first conduit, with a first treated liquid passing from the tangential filter to the supply vessel via said second conduit and a second treated liquid passing from the tangential filter to a collection vessel via said first conduit.
    [0014] Thanks to the invention it is possible to directly supply the tangential filter through the first conduit, and, in addition, the first treated liquid is sent directly back from the tangential filter thanks to the second conduit.
    [0015] Thus, the so-called dead volume of liquid to be treated and treated liquid is minimized in the bag and, with this, in the circuit.
    [0016] Additionally, the bag is configured so that the longitudinal direction coincides with the horizontal, such that the second and fourth conduits are above the first conduit and the third conduit is below the first conduit.
    [0017] Additionally, the bag according to the invention fully meets the restrictions imposed on a two-dimensional circuit (which prevents the crossing of ducts), thanks to the arrangement of the first duct and second duct that are arranged in parallel with equal spacing between their respective opposite connectors.
    [0018] However, the first conduit has a slightly negative inclination between the flow pump connector and the junction between the first conduit and the third conduit, and, in addition, with a slightly negative inclination between the tangential filter connector and that same junction, to drain the second processed liquid from the filter.
    [0019] To be precise, in this flow direction, there is no pump to assist the flow, contrary to the previous transport of the liquid to be treated to the filter.
    [0020] According to particularly simple, advantageous and economical characteristics of the bag according to the invention: - the bag comprises a fifth conduit connected to a transfer pump connector, and a sixth conduit extending from a container connector- source until entering said fifth conduit; - the pouch comprises at least a seventh conduit that extends from a buffer and / or cleaning container connector until it enters the fifth conduit; - the bag comprises an eighth conduit that extends between an air filter connector and a rinsing container connector, said fifth conduit entering said eighth conduit; and - the bag comprises at least one ninth conduit that extends between a tangential filter connector and a waste container connector;
    [0021] According to a second aspect, the invention also relates to a device for an installation for the treatment of biological liquid by means of tangential filtration, which comprises a circuit comprising: - a pouch provided with a plurality of connectors and a network for transporting liquid between said connectors, said transport network being formed by a plurality of conduits, the bag additionally comprising two flexible films attached to each other, said conduits being formed between said flexible films; - a press comprising a first layer and a second layer mounted on said first layer, said first layer and second layer cooperating with said bag to form the conduits of said transport network between said flexible films, by means of clamping said bag between said first layer and said second layer; and - a plurality of valves; a first conduit that extends longitudinally between a flow pump connector that emerges on a first side of said bag and a tangential filter connector that emerges on a second side of said bag that is a side opposite to said first side; a second conduit extending longitudinally from a first side of said conduit between a connector of the supply container that emerges on said first side of said bag, and another tangential filter connector that emerges on said second side of said bag that is a side opposite to said first side; a third conduit extending from a second side of said conduit, which is a side opposite to said first side of said conduit, starting at a connector of the collection container, until it enters said first conduit; and a fourth conduit extending from the first side of said conduit of a transfer pump connector until it enters said second conduit; at least one first valve which is located in said conduit, at least one second valve which is located in said second conduit, a third valve which is located in said third conduit, and a fourth valve which is located in said fourth conduit.
    [0022] Thanks to the invention, the device for the treatment installation is particularly advantageous because it allows to carry out the treatment by means of tangential filtration (by opening and closing valves, thereby allowing or preventing the flow of liquid in the ducts) simply and with less occupied space.
    [0023] Additionally, depending on the treatments carried out, the biological liquid treatment installation comprises, in addition to the device according to the invention, one or more other devices, for example, juxtaposed against the device according to the invention.
    [0024] This other device or these other devices is or is provided with the treatment components of the surroundings as mentioned above formed in particular by one or more pumps, for example, of the peristaltic type, and / or by means of a source container containing the product to be treated and / or by means of a treated liquid collection container, and these treatment components in the vicinity are connected to the bag, directly or not.
    [0025] According to particularly simple, advantageous and economical characteristics of the device according to the invention: - the bag comprises a fifth conduit connected to a transfer pump connector, and a sixth conduit extending from a container connector- source until it enters the fifth conduit, and the device comprises a fifth valve located in said fifth conduit and a sixth valve located in said sixth conduit; - the pouch comprises at least a seventh conduit extending from a buffer and / or cleaning container connector until it enters the fifth conduit, and the device comprises at least one seventh valve located in said seventh conduit; the pouch comprises an eighth conduit extending between an air filter connector and a rinsing container connector, said fifth conduit entering said eighth conduit, and the device comprising at least one eighth valve located in said eighth conduit; - the pouch comprises at least one ninth conduit that extends between a tangential filter connector and a waste container connector, and the device comprises at least one ninth valve located in said ninth conduit; and - the device comprises a pressure sensor located in at least one said conduit.
    [0026] The disclosure of the invention will now be continued with the description of embodiments, given below as an illustrative and non-limiting example, with reference to the accompanying drawings, in which: - Figure 1 is a perspective view of an installation device for liquid treatment by means of tangential filtration; - Figure 2 is a side view of the device; - Figure 3 is a rear view of a first cover of the device, with a back panel removed; Figures 4 and 5 are seen in cross section of the device, respectively with an open valve and a closed valve; - Figure 6 is a front view of the first layer, on which a bag for the treatment of liquid by means of tangential filtration is mounted. - Figure 7 is a front view of the bag in isolation; and - Figure 8 is a diagrammatic view of the circuit of an installation for treating liquid by means of tangential filtration;
    [0027] Figures 1 and 2 illustrate a device 1 for an installation for treating biological liquid by means of tangential filtration.
    [0028] Device 1 has a general shape of parallelepiped.
    [0029] This device 1 comprises a base 2 having a first side face 3, a second side face 4 which is opposite the first side face 3, a front face 5 which meets the first and second side faces 3 and 4, and a rear face 6 which is a face opposite to the front face 5 and which meets the first and second side faces 3 and 4.
    [0030] Device 1 additionally comprises a circuit 8 provided with a press 9 and a pocket 10, comprising a plurality of connectors 11 (from 11 A to 11 P in Figures 6 and 7) for liquid and a network 12 for transporting liquid between these connectors 11 including conduits 13 (from 13A to 13K in Figures 6 and 7), as will be seen in more detail below.
    [0031] Press 9 comprises two layers 16 and 17, each formed from a solid block of rigid material.
    [0032] Here, layers 16 and 17 are made of polyoxymethylene (POM), also called acetal, and each one has a general shape of parallelepiped.
    [0033] The cover 16 is mounted on the front face 5 of the base 2.
    [0034] The device 1 additionally comprises a door 20 hinged to the base 2.
    [0035] Cover 17 is mounted on that port 20.
    [0036] Device 1 has a closed door position in which door 20 is closed and covers cover 16 (Figure 2), and another position in which pocket 10 is supported only by cover 16 (Figure 1).
    [0037] In this other position, the cover 17 is far from the cover 16. In the closed position, the pocket 10 is inserted between the two layers 16 and 17.
    [0038] Device 1 is equipped, at the bottom, with a closed cabinet 46 intended to receive one or more tanks (represented diagrammatically in Figure 6) comprising a bag, said tanks forming, for example, a container for collecting treated liquids or a disposal container as will be seen later.
    [0039] This cabinet 46 is closed by a sliding panel 7 arranged on the front face 5 of the device 1, said panel 7 being adapted to be moved in downward translation, then towards the back of the device 1 (see the arrows on Figure 1) in order to insert and remove the tanks.
    [0040] A control panel 14 is arranged on top of the front face 5 of device 1.
    [0041] This control panel 14 is equipped with a graphical touch interface 15 that allows to verify and control the biological liquid treatment process.
    [0042] This control panel 14 is, therefore, arranged at a height that allows a user to use it.
    [0043] To facilitate its movement, device 1 is in the form of a cart mounted on four casters 18 (three of which can be seen in Figure 1), two casters being located under the front face of the device 5 comprising [m] a brake 19, and device 1 additionally having two handles 21 on respective opposite sides of the front face 5, in the vicinity of the respective side faces 3 and 4.
    [0044] Device 1 comprises an inclined chassis 25 on its front face 5.
    [0045] On each of its left and right sides, the chassis 25 comprises two overlapping L-shaped claws 26 that emerge from the respective side and extend upwards.
    [0046] A support plate 27 is attached to the right side of the chassis 25, between the two hitch claws 26.
    [0047] This support plate 27 is arranged in the immediate vicinity under the hitch claw 26 located higher on the right side, in order to allow free access to the hitch claw 26 located lower on that same right side.
    [0048] The support plate 27 comprises two fixing heads 28 on which a platform (not shown) is adapted to be fixed in order to present on it the tangential filter necessary for the treatment of the biological liquid.
    [0049] The base 2 of the device 1 additionally comprises devices 29 which, with complementary devices 40 of the door 20, allow the positioning and locking of that door 20 in the closed door position.
    [0050] There are three of the devices 29, which are located in the corners of the chassis 25, respectively on the top right, bottom on the right, and bottom on the left.
    [0051] These devices 29 each comprise a body, an annular shoulder (not shown), a head connected to that annular shoulder, with that head having the shape of a conical tube and having an internal stem 30 with a conical tip. The body comprises a pneumatic chamber, a plunger that is mechanically connected to the stem 30 with a conical tip, said stem 30 being adapted to extend inside the head.
    [0052] Door 20 comprises a frame 35 having a generally rectangular profile.
    [0053] The frame 35 comprises four sides and three complementary devices 40 adapted to cooperate with the devices 29 of the base 2, said complementary devices 40 being located respectively in the upper left, lower left, and lower right.
    [0054] These complementary devices 40 are provided with a first cylindrical portion and a second cylindrical portion that is hollow and connected to the first portion by means of a shoulder. This second portion has a smaller diameter than the diameter of the first first portion. In addition, the second portion has three holes in the outer surface.
    These complementary devices 40 additionally comprise three balls (not shown), each capable of protruding from the second portion when passing through a respective orifice.
    [0056] In the closed door position, each second portion of a respective complementary device 40 of the door 20 is inserted in a respective head of a respective device 29 of the base 2.
    [0057] The devices 29 and complementary devices 40 form, in pairs, a ball locking pin system equipped with a double-acting pneumatic cylinder with a spring (not shown), presenting an extended position and a retracted position, its operation is well known.
    [0058] The rod 30 of the device 29 is adapted to be inserted in the second hollow cylindrical portion when the [neumatic] cylinder is in its extended position.
    [0059] In this position of the [neumatic] cylinder, the rod 30 pushes the balls until each one passes through a hole, thus blocking the movement of the door 20 relative to the base 2.
    [0060] The device 1 additionally comprises a hinge system by means of which the door 20 is hinged to the base 2.
    [0061] This hinge system is provided with a single hinge 42 comprising a first hinge portion 43 attached to the upper right corner of frame 35 of door 20, and a second hinge portion (not shown) attached to the side face 3 of the base 2 from device 1.
    [0062] At the top of the second hinge portion a mechanical spring (not shown) is arranged with a plastic stop to facilitate opening and closing the door 20.
    [0063] The device also includes a position sensor (not shown) to check and provide security for opening and closing door 20, by detecting the position of the closed door and the other position.
    [0064] A pneumatic system (not shown) is also arranged on top of the second hinge portion in order to supply a system (not shown) for locking the cover 17 and which is located on the door 20.
    [0065] In the closed door position, the rotational axis around which the first hinge portion 43 of the door 20 pivots is displaced relative to a starting surface formed between the covers 16 and 17 when they clamp the pocket 10 with each other.
    [0066] This axial displacement towards the front of the device 1 allows lateral spaces to be formed between the door 20 and the base 2 in the outer perimeter of the door 20 (Figure 2).
    [0067] Thus, access to connectors 11 of bag 10 is very easy.
    [0068] The cover 17 has a reference surface 80, which is flat here, and a plurality of shaping channels 81 embedded in that reference surface 80. This cover 17 has a first side first side 82 and a second side 83 which is a side opposite the first side 82, a third side 84 and a fourth side 85 which is a side opposite the third side 84, each of these third and fourth sides 84 and 85 meeting the first and second sides 82 and 83.
    [0069] On its fourth side 85, the cover 17 is provided with three positioning holes 86 to position the pocket 10, which are arranged facing positioning holes 73 of the pocket 10 in the closed door position, with [the] pocket 10 clamped between layers 16 and 17.
    [0070] Additionally, the cover 17 is provided with two other positioning holes 87 to position the door 20 in the closed door position, one of which is located on the first side 82 of the cover 17, and the other on the other end, towards the bottom cover 17.
    [0071] These two positioning holes 87 are arranged so that they face the positioning holes 77 of the pocket 10 in the closed door position, with the pocket 10 clamped between the covers 16 and 17.
    [0072] In a central zone, the cover 17 additionally comprises two locking holes 88 with a larger diameter than the positioning holes 86 and 87 of that cover 17, said locking holes 88 being used for the joint locking of the covers 16 and 17.
    [0073] These two locking holes 88 are located in the places where there are most of the channels 81 that serve for the formation of the ducts 13, because it is in these places that the pressure force is the greatest during the treatment. The locking holes 88 are therefore at least partially surrounded by channels 81.
    [0074] These locking holes 88 are arranged so that they face the locking holes 75 of the pocket 10 in the closed door position, with the pocket 10 clamped between the covers 16 and 17.
    [0075] The cover 16 has a flat reference surface 95 and modeling channels 96 embedded in relation to the reference surface 95 (Figure 4), each facing a corresponding modeling channel 81.
    [0076] In general, surfaces 80 and 95 have similar dimensions and the layout of the modeling channels 96 is the mirror image of the set of modeling channels 81.
    [0077] The modeling channels 81 and 96 have a semi-elliptical cross section.
    [0078] Surfaces 80 and 95 can be applied against each other with channels 81 and 96 in mutual confrontation to delimit a network of cavities that are, each, generally tubular.
    [0079] The cover 16 has a first side 145 and a second side 146 which is a side opposite the first side 145, a third side 147 and a fourth side 148 which is a side opposite the third side 147, each of which said third and fourth sides 147 and 148 meet the first and second sides 145 and 146 (Figure 6).
    [0080] The cover 16 additionally features, on the opposite side walls 98 and 99, pins 100 adapted to connect, thanks to a vertical translation movement from the top to the bottom when the cover 16 is against the chassis 25, in the coupling claws 26 arranged in that chassis 25.
    [0081] Additionally, in those same opposite side walls 98 and 99, the cover 16 has rods 101 to manipulate the cover 16.
    [0082] This manipulation is performed by the user of device 1, or with the help of a winch, which can be, for example, electric.
    [0083] Thanks to the slope and the weight of the cover 16, and thanks to the connection of the pins 100 in the coupling claws 26, the cover 16 is securely fixed to the chassis 25.
    [0084] On its flat reference surface 95, the cover 16 additionally has a recessed portion 102 which is extended downwards by means of an inclined surface 103, said inclination being directed into the device 1.
    [0085] This inclined surface 103 allows access to cabinet 46 including the containers.
    [0086] On a bottom face 97, the cover 16 additionally comprises a channel 104 in the form of an inverted drain that emerges on the inclined surface 103 (Figure 1).
    [0087] This channel 104 serves as a fail-safe device in the installation of the cover 16 in the chassis 25 of the base 2, so that the reference surface 95 can be rotated inward.
    [0088] The cover 16 additionally comprises, in the place of its fourth side 148, three latching pins 106, of which two are arranged on the respective opposite sides of the cover 16, the third being substantially disposed in the center of the fourth side 148 of cover 16, with those three pins 106 evenly spaced from each other.
    [0089] These pins 106 are adapted to pass through the positioning holes 73 of the pocket 10 for the suspension of the latter in the cover 16.
    [0090] Additionally, the distal end of these same engagement pins 106 is adapted to be inserted into the positioning holes 86 of the cover 17 in the closed door position.
    [0091] The cover 16 comprises two positioning pins 107 for positioning the door 20, one of which is positioned on the fourth side 148 of the cover 16 next to a latch pin 106 located at the top left of that cover 16, the other pin positioning 107 located at the other end, ie at the bottom of the cover 16, between two modeling channels 96 at the location of the third side 147.
    [0092] These positioning pins 107 are adapted to pass through holes 77 of pocket 10, and the distal end of these positioning pins 107 is adapted to be inserted into positioning holes 87 of cover 17.
    [0093] The cover 16 additionally comprises two locking holes 108 which are located in the places where there is most of the channels 96 that serves for the formation of the ducts 13, because it is in these places that the pressure force is the greatest during the treatment. The locking holes 108 are therefore at least partially surrounded by channels 96.
    [0094] These locking holes 108 are arranged so that they face the passage holes for locking 75 of the pocket 10 when it is arranged in the cover 16, and also facing the corresponding locking holes 88 of the cover 17 in the closed door position.
    [0095] The locking holes 108 of the cover 16 are passed through the ball locking pins 110 for the mutual locking of the covers 16 and 17 when the door 20 is in its closed position, and for the clamping of the bag 10 in the circuit 8.
    [0096] Each ball locking pin 110 comprises a body connected to the cover 16, and an annular shoulder provided with a transverse face and connected to a head (which are not shown). The body comprises a pneumatic chamber and a plunger, the plunger being mechanically connected to a rod with a conical tip (not shown). This rod extends into the head of the pin 110 and three balls 119 (Figure 6) are arranged so as to be able to project from the head through holes formed in that head. Pin 110 is similar to a double-acting [neumatic] cylinder and has an extended position and a retracted position.
    [0097] The head of each pin 110 passes through the corresponding locking hole of cover 16, this head also passing through the corresponding locking hole 75 of the bag, and this head finally emerges in a corresponding locking hole 88 of the cover 17 in the closed door position.
    [0098] When a first portion of the pin 110 pneumatic chamber is placed under pressure, the plunger acts on it. When the plunger reaches the end of its travel, the balls 119 are in an extended position, that is to say that they protrude from the head to extend inside the locking hole 88 of the cover 17.
    [0099] The locking holes 88 are configured so that, when the balls 119 are extended, the covers 16 and 17 remain securely locked.
    [0100] When a second portion of the pneumatic chamber of pin 110 is placed under pressure, this second portion is opposite the first portion, the plunger is pressed towards the other end of the travel position. When that position is reached, the balls 119 are in a retracted position, that is, they return to the head.
    [0101] In addition to layers 16 and 17, device 1 comprises, here installed at the rear of layer 16, instruments required for the treatment of the biological liquid illustrated in Figure 3.
    [0102] Clamping valves 125A to 125N are illustrated (Figure 3) comprising actuators 221 (Figures 4 and 5) for clamping a conduit 13 in order to prevent or allow the passage of liquid in that conduit 13, and pressure sensors of 126A to 126D.
    [0103] A pneumatic distributor 128 and means for verification and control to perform various treatments of that liquid are also illustrated, said means being formed, for example, by a verification and control unit 127.
    [0104] In the example illustrated in Figures 4 and 5, actuators 221 each comprise a body 223 attached to the cover 16 and a movable clamping finger 224 showing a retracted position when valve 125 is in the open position and [in] an extended position when valve 125 is in the closed position.
    [0105] The body 223 comprises a pneumatic chamber 226, a plunger 227 and an accommodation 228 provided with a spring 229 accommodated in the cover, with the spring 229 surrounding a rod connecting the plunger 227 and the finger 224.
    [0106] The pneumatic chamber 226, when under pressure, forces the plunger 227 against the spring 229. When the plunger 227 is at the end of its cycle, the finger 224 is in a retracted position (Figures 4).
    [0107] When the pneumatic chamber 226 is under atmospheric pressure, the spring 229 forces the piston 227 in the direction of the other end of cycle position.
    [0108] When the latter is reached, the mobile finger 224 is in an extended position (Figure 5).
    [0109] At its distal end, the movable finger 224 is modeled after the profile of the modeling channel 81 of the cover 17.
    [0110] In the extended position, the movable finger 224 protrudes into one of the channels 81.
    [0111] The valve 125 further comprises, in comparison with the movable finger 224, an elastically compressible pad 231, said pad 231 being part of an individual local silicone plate 230 molded in one piece (see also Figure 1) .
    [0112] This pad 231 has a first face 232 closest to the movable finger 224 and a second face 233 closest to the tube to be clamped 13.
    [0113] The second face 233 of the cushion 231 is concave and delimits locally the modeling channel 96 of the cover 16.
    [0114] Each actuator 221 allows a tube 13 to be clamped between its movable finger 224 and cap 17, in order to allow or prevent the passage of liquid in the place.
    [0115] To clamp tube 13, valve 125 passes from its open position (Figure 4) where the movable finger 224 is in a retracted position where it does not clamp tube 13, to its closed position (Figure 5) in that the movable finger 224 is in an extended position where it clamps the tube 13.
    [0116] The finger 224, as it is extended, pushes the pad 231 towards the modeling channel 81 of the cover 17.
    [0117] Thus, the pad 231 changes from a resting configuration in which its second face 233 is concave and delimits locally the modeling channel 96 of the cover 16 of the tube 13 to be clamped, to a clamping configuration in which its second face 233 it is convex, with the tube 13 and the pad 231 sandwiched between the shaping channel 81 of the cover 17 of the tube to be pinched 13 and the movable pinching finger 224.
    [0118] In addition, each sensor 126A-D is attached to the cover 16 in confrontation with a channel 96, with the distal end of sensor 126 emerging from that of channel 96, without actually having to touch the fluid (not shown).
    [0119] Said pressure sensors measure the pressure via the outer surface of the bag 10.
    [0120] The cover 16 additionally comprises, here installed behind the cover 16, a female connector 130 that allows supplying power to the valves 125A-N, sensors 126A-D the distributor 128 and the verification and control unit 127, which are integrated on that cover 16 (Figure 3).
    [0121] The supply is therefore electric (for power and control) and pneumatic.
    [0122] This female connector 130 is located at the bottom to the right of cover 16 (seen from behind).
    [0123] When the back of the cover 16 is covered by a rear panel (not shown), only access to the female connector 130 is possible.
    [0124] A male connector (not shown) disposed on the base 2 of the device 1 can be connected to the female connector 130 of the circuit 8.
    [0125] The pouch 10 comprises two flexible films 65 and 66 connected to each other by means of a seal that delimits a closed contour (Figures 4 and 7), and the connectors 11 of the transport network 12.
    [0126] Thus, each of the films 65 and 66 is an applicant's PureFlex ™ film.
    [0127] This is a co-extruded film comprising four layers, respectively, from the inside to the outside, a layer of ultra low density polyethylene (ULDPE) forming the material for contact with a liquid, a copolymer of ethylene and vinyl alcohol (EVOH) forming a gas barrier, a layer of ethylene and vinyl acetate copolymer (EVA) and a layer of ultra low density polyethylene (ULDPE) forming the outer layers.
    [0128] The seal is a weld bead formed on the periphery of films 65 and 66 at the location of ducts 13.
    [0129] Ducts 13 (13A to 13K in Figures 6 and 7) are formed in the passage of a liquid.
    [0130] The closed contour of the pouch 10 forms a liquid treatment zone 67 (Figure 7), in which the conduits 13A-K extend.
    [0131] The closed contour has a first side 68, a second side 69 that is opposite the first 68, a third side 70 that meets the first and second sides 68 and 69 and a fourth side 71 that is an opposite side to the third side 70 and that meets the first and second sides 36 and 69. The connectors 11A to 11P of the transport network 12 emerge in and out of the first, second, and third sides 68, 69, and 70, as can be seen more particularly in Figure 7.
    [0132] The dimensions of bag 10 correspond to those of the surfaces of covers 16 and 17.
    [0133] The pouch 10 is provided for clamping by the covers 16 and 17 with one side of the pouch 10 in contact with the face of the cover 16, and with the other face of the pouch 10 being in contact with one face of the cover 17.
    [0134] On its fourth side 71, pocket 10 additionally comprises the three through holes 73 for positioning which have been mentioned above.
    [0135] These positioning holes 73 are aligned and spaced regularly, with two of the holes 73 being located on respective opposite sides of the fourth side 71 of the pocket 10, and the other hole 73 is located in the center of the fourth side 71 of bag 10.
    [0136] These positioning holes 73 are for positioning the pocket 10 on the cover 16.
    [0137] The pouch 10 additionally comprises, in its treatment zone 67, the two through holes 75 mentioned above for locking the covers 16 and 17 with each other, these locking holes 75 having a larger diameter than the positioning holes 73.
    [0138] These locking holes 75 are located in the treatment zone 67 in the places where there is the largest amount of ducts 13, because it is in these places where the pressure force is the greatest during the treatment. The locking holes 75 are therefore at least partially surrounded by conduits 13.
    [0139] The pouch 10 further comprises two other positioning holes 77 referred to above which serve to position the door 20 in the closed door position of the device.
    [0140] One of the positioning holes 77 is located on the fourth side 71 of the pocket 10 in the vicinity of the positioning hole 73 located on the top left of the pocket 10, and the other positioning hole 77 is located on the opposite end. , that is, towards the bottom of the pocket 10, in the treatment area 67.
    [0141] A more detailed description will now be given with respect to the ducts 13A to 13K and the connectors 11A to 11P of bag 10, as well as the valves from 125A to 125N and sensors from 126A to 126D that are integrated in the cover 16 and the components of the surroundings that cooperate with the ducts 13A to 13K and the connectors 11A to 11P, with reference to figures 6 and 7.
    [0142] The treatment components of the surroundings are formed in particular by diaphragm pumps, several containers and other measuring instruments, as will be seen below.
    [0143] These neighborhood treatment components are represented here diagrammatically and placed against and connected to bag 10, which is mounted on cover 16 (Figure 6), or only to bag 10 (Figure 7), but in reality, these components they are arranged on one or more other devices, for example, placed against device 1.
    [0144] Advantageously, these other devices are trolleys like device 1.
    [0145] Evidently, the connections that will be described below can be formed before fixing pouch 10 by hanging on cover 16, without subsequent obstruction, that is, at the moment of suspending that pouch on cover 16, through the hinge system , or after the suspension of that scholarship 10.
    [0146] On its first side 68, the pouch 10 comprises a connector 11B connected to a conduit 13B that extends horizontally across the entire length of the pouch 10 starting from the connector 11B to the second side 69 of the pouch 10 where it is coupled to a 11N connector.
    [0147] Connector 11B is connected to a supply container 400 and connector 11N is connected to a tangential filter 401.
    [0148] On its first side 68, the pocket 10 additionally comprises, above connector 11B, a connector 11A connected to a conduit 13A comprising a first section that extends horizontally from that connector 11 A, then a second folded section and, finally, a third section that extends vertically downwards until it enters the conduit 13B, in the manner of a T-shaped branch connector.
    [0149] Connector 11 A is connected to a 403 transfer pump.
    [0150] Still on its first side 68, the pouch comprises, under connector 11B, a connector 11C connected to a conduit 13C that extends substantially horizontally across the entire length of pouch 10 starting from connector 11C to the second side 69 of the bag 10 where that conduit 13C is connected to an 11M connector.
    [0151] The 11C connector is connected to a 404 flow pump and the 11M connector is connected to the tangential filter 401.
    [0152] Advantageously, the product flow between the flow pump 404 and the tangential filter 401 is made in a substantially straight section, directly, and over the length of the bag. In other words, the length of the bag comprising the product is very short.
    [0153] Under connector 11C, pouch 10 also comprises a connector 11D connected to a conduit 13D that has a first section that extends horizontally over more than half the length of the pouch 10, a second folded section and a third section that extends vertically down to the third side 70 of the pocket 10 where the third section is coupled to a connector 111.
    [0154] Connector 11D is connected to an air filter and connector 111 is connected to a 409 container for rinsing liquid.
    [0155] Bag 10 further comprises, still on its first side 68, under connector 11 D, a connector 11E connected to a conduit 13K that extends horizontally over more than half the length of bag 10 from connector 11E until it into the third section of conduit 13D that extends vertically down to connector 111.
    [0156] Connector 11E is connected to a transfer pump 403, and said transfer pump 403 is connected via a transfer section 500 to connector 11A of bag 10.
    [0157] On its third side 70 (the bottom of the pocket 10) the pocket 10 comprises a connector 11F connected to a conduit 13E that extends vertically upwards from the connector 11F until it enters the conduit 13K that extends horizontally.
    [0158] The 11F connector is connected to a source product container.
    [0159] On its third side 70, the pocket 10 additionally comprises a connector 11G connected to a conduit 13F that extends vertically upwards from the connector 11G until it enters the conduit 13K.
    [0160] The 11G connector is connected to a 407 container of buffering product. On its side 70, the pouch 10 comprises a connector 11H connected to a conduit 13G that extends vertically upwards from the connector 11H until it enters the conduit 13K.
    [0161] The 11H connector is connected to a 408 container for cleaning liquid.
    [0162] Connectors 11F, 11C and 11H are located between the lower left corner of bag 10 and connector 111 described above.
    [0163] After this connector 111 (that is, between this connector and the lower right corner of bag 10), bag 10 comprises a connector 11J connected to a conduit 13H that extends vertically upwards from connector 11J until it enters conduit 13C in the manner of a T-shaped branch connector.
    [0164] Connector 11J is connected to a collection container 410 for treated liquid.
    [0165] It should be noted, therefore, that conduit 13C has two sections, one that extends between connector 11C and the intersection with conduit 13H, and the other that extends between connectors 11M and the intersection with conduit 13H.
    [0166] Each section of this 13C conduit is substantially horizontal, however, with an inclination respectively away from the 11C, 11M connector until the intersection with the 13H conduit, in the order of a few degrees (for example, from 2 to 3 °).
    [0167] Still on its third side 70, the pouch 10 comprises a connector 11K connected to a conduit 131 that has a first section that extends vertically upwards from the connector 11K, a second section folded towards the second side 69 of the pouch 10 , and a third section that extends substantially horizontally from the second folded section to the second side 69 of the pocket 10 where the conduit 131 is coupled to a connector 11L.
    [0168] Connector 11K is connected to a waste container 411 and connector 11L is connected to tangential filter 401.
    [0169] This 11L connector is additionally located under the 11M connector described above, which is located under the 11N connector also described above.
    [0170] On its second side 69, above connector 11N, pouch 10 comprises a connector 110 coupled to a conduit 13J which has a first section that extends substantially horizontally from connector 110 towards the first side 68 of pouch 10 ( slightly positive inclination), a second section folded upwards, a third section that extends vertically upwards, a fourth section folded towards the second side 69 of bag 10, and a fifth section that extends substantially horizontally from the third section folded up to the second side 69 of the bag where the conduit 13J is connected to a connector 11P (with a slightly positive inclination).
    [0171] The fifth section of the 13J conduit comprises, in the vicinity of the third folded section, a neck.
    [0172] Connector 110 is connected to tangential filter 401 and connector 11P is connected to a 412 waste container.
    [0173] The cover 16 comprises a pressure sensor 126A in the first portion of the conduit 13A and a pressure sensor 126B in the connector 11N of the conduit 13B.
    [0174] The cover 16 additionally comprises a valve 125A and an elastic buffer 231A located in the third vertical section of conduit 13A and a valve 125B and a buffer 231 B in conduit 13B between connector 11B and the intersection between connectors 13A and 13B, and a valve 125C and an elastic buffer 231C in the conduit 13B between that intersection and the pressure sensor 126B.
    [0175] The cover 16 comprises a valve 125D and an elastic buffer 231D in the conduit 13C in the vicinity of the intersection of that conduit 13C with the conduit 13H, between the connector 11C and that intersection. In that same conduit 13C, between the intersection and the 11M connector the cover comprises a 125E valve and an elastic buffer 231 E.
    [0176] Additionally, the cover 16 comprises a pressure sensor 126C in the conduit 13C between the valve 125D associated with the buffer 231 D and the connector 11C.
    [0177] This cover 16 additionally comprises valve 125F and an elastic buffer 231F in conduit 13H in the vicinity of the intersection between that conduit 13H and conduit 13C.
    [0178] The cover 16 also comprises a 125G valve and an elastic buffer 231G in the third section of the 13D conduit, immediately after the second folded section, and before the location of that third section into which the 13K conduit enters.
    [0179] The cover 16 additionally comprises the valve 125H and an elastic buffer 231H in the conduit 13K between the location of that conduit 13K into which conduit 13E enters and the location of that conduit 13K into which conduit 13F enters.
    [0180] The cover 16 comprises a valve 1251 and an elastic buffer 2311 in the conduit 13E.
    [0181] The cover 16 comprises a valve 125J and an elastic buffer 231J in the conduit 13F.
    [0182] The cover 16 comprises a 125K valve and an elastic buffer 231K in the 13G conduit.
    [0183] The cover 16 comprises a valve 125L and an elastic buffer 231L in the third section of the conduit 13D, but contrary to the valve 125G and elastic buffer 231G, this valve 125K and this buffer 231K are located between connector 111 and the location of the third section of the 13D conduit into which the 13K conduit enters.
    [0184] The cover 16 additionally comprises a valve 125M and an elastic buffer 231M in the third section of the conduit 131, that is, between the second folded section and the connector 11L.
    [0185] The cover 16 finally comprises a valve 125N and an elastic buffer 231N in the third section (which is vertical) of the conduit 13J, and also a pressure sensor 126D located in the first section of that conduit 13J, immediately before the second section which is Tripe.
    [0186] Each connector from 11A to 11P has a semi-elliptical cross section and is provided with a longitudinal conduit 90 on which two annular walls 91 and 92 are formed, defining a tubular portion 93 between them, the annular wall 91 being juxtaposed against the films 65 and 66 of the pocket 10 and the annular wall 92 being displaced relative to its films 65 and 66 towards the end of the conduit 90 in which a tube is connected for its connection to a component in the vicinity.
    [0187] The films 65 and 66 of the pouch 10 are sealed around the tubular portion 93 of each connector 11 in a collar 94.
    [0188] A description will now be presented detailing the circuit for processing liquid by means of tangential filtration, with reference to Figure 8, with the components in the vicinity.
    [0189] Figure 8 shows diagrammatically the circuit 8 provided by the press 9 and bag 10. In this circuit the valves 125A to 125K are formed respectively by an actuator 221, and by the portion of the cover 17 against which the conduit 13 presses when it is pinched by finger 224.
    [0190] The liquid to be treated is initially found in a 406 source bag, filled with liquid from the bioreactor or from the previous treatment. This source bag 406 is connectable via a male connector 506 to the transfer conduit 13E that extends between a female connector 11F and another female connector 11E, with that transfer conduit 13E being connectable via its female connector 11E, to a transfer section , which is connectable to the transfer duct 13A that extends between its female connector 11A to a first hole 323a of a T-shaped branch connector 323 (formed by crossing the ducts 13B and 13C).
    [0191] This transfer section comprises disposable flexible ducts, a 403 transfer pump to circulate the liquid (here a peristaltic pump) and two valves 125A and 1251.
    [0192] The term "conduit" needs to be understood in this document as being a portion of piping that connects two elements of the circuit, it being possible that this portion also comprises a single pipe or, on the contrary, several pipes, possibly having different diameters, connected in series by means of a simple connector (not playing any other role here) or a sophisticated connector (for example, a disposable connector for a pressure sensor (or for a sensor of other physical-chemical value)).
    [0193] Pump 403 is traversed by a duct (from a first entry / exit point 703 to a second entry / exit point 603) such that the duct can be compressed by pump 403.
    [0194] The 125A valve is implanted in the conduit 13A near the branch connector 323 in order to allow or prevent the flow of liquid in the conductor.
    [0195] The transfer section also comprises a connector for the 126A pressure sensor.
    [0196] The 1251 valve is implanted in tube 13E near the female connector 11F.
    [0197] The operator has the possibility to connect other bags 407, 408, 409 and a 405 filter to a transfer conduit 13K that meets conduit 13E, via the respective male connectors 507, 508, 509 and 505 that can be connected on the respective female connectors 11G, 11H, 111 and 11 D.
    [0198] These bags 407, 408 and 409 contain a buffer liquid (saline solution), a cleaning liquid (sodium hydroxide) and a rinse liquid (water) respectively to control the clean state of the circuit or to push the liquid treated towards the components that perform the treatment or towards the collection container, and the filter is an air filter.
    [0199] Conduit 13B has two sections, one of which is for filling (between connector 11A and the intersection of conduit 13B and conduit 13A) and the other is for filtration (between connector 11N and the intersection of conduit 13B and conduit 13A), the sections of which respectively extend from a second orifice 323b and a third orifice 323c of the branch connector 323.
    [0200] The filling section that meets an inlet / outlet port 500 of the disposable flexible supply container 400 comprises a valve 125B implanted in the vicinity of the branch connector 323 (also disposable).
    [0201] A stirring bar 420 actuated by an electromagnetic impeller 425 is arranged in the container 400 to make the liquid held there homogeneous.
    [0202] The 13C conduit has two sections, one of which forms a filtration section that connects a first 360a orifice of a T-shaped branch connector 360, and comprises a connector for the 126C pressure sensor, two isolation valves 125D and 125E and the tangential connector 401, and the other a supply section.
    [0203] The conduit 13B connects the third hole 323c of the branch connector 323 to a first inlet / outlet of the filter 401 via the connector 11N.
    [0204] Conduit 51 connects a second inlet / outlet port of filter 401 to the first port 360a of the branch connector 360 via the 11M connector.
    [0205] The measurement made by the pressure sensor 126B makes it possible to know the functional state of the tangential filter 401.
    [0206] Valve 125C is implanted in conduit 13B next to branch connector 323, while valve 125E is implanted in conduit 13C near branch connector 360.
    [0207] A supply section and a collection section respectively extend from a second hole 360b and a third hole 360c of the 360 branch connector.
    [0208] The supply section connects to an outlet port 600 of the supply container 400. It comprises a disposable flexible conduit, a 404 flow pump to make the liquid flow (here, a peristaltic pump), a 125D valve implanted in the 13C conduit near the 360 branch connector, and a connector for the 126C pressure sensor inserted in series in the 13C conduit.
    [0209] The supply section has a portion 704 that passes through the pump 404 (from an entry point 504 to an exit point 604) in such a way that it can be compressed by the pump.
    [0210] The supply section additionally comprises a section of the 13C duct located between the 125D valve and the 11C connector connected to the 404 flow pump.
    [0211] The collection section finds the female connector 11 J. It comprises only the 13H conduit and the 125F isolation valve implanted in the 13H conduit next to the 360 branch connector.
    [0212] Depending on the operations performed, the connector 11J can be connected to either a male connector 511 of a waste container 411, or to the male connector 510 of a collection container 410.
    [0213] The tangential filtration treatment circuit also comprises two conduits 13J and 131 to transport the filtrate that respectively extend from the exit points of the filter 401 via the respective connectors 110 and 11L of the bag 10, with the conduits 13J and 131 are connected via the respective connectors 11P and 11K to the respective male connectors 512 and 511 of the respective collection containers 412 and 411. It is possible to interpose a flow meter (not shown) in such a way to be able to determine the volume and the flow rate of the filtrate recovered at the 401 filter outlet.
    [0214] The respective valves 125N and 125M are installed respectively in respective conduits 13J and 131, near filter 401, and a connector for pressure sensor 126D is implanted in conduit 13J, between valve 125N and filter 401.
    [0215] The measurement made by the 126D pressure sensor, together with the measurement made by the 126B pressure sensor, allows to precisely check the functional status of the tangential filter 401.
    [0216] The operation of this circuit will now be described.
    [0217] Valves 125C, 125 and 125F are closed to prevent any flow of liquid in the filtration and collection sections, the other valves being open.
    [0218] The source bag 406 is coupled to the transfer section by connecting the male connector 506 to the female connector 11F and by connecting the male connector 503 to the female connector 11E.
    [0219] The liquid to be treated is then sucked from the source bag 406 by means of transfer pump 403 and is transported to the supply container 400 via transfer section 13A and filling section 13B.
    [0220] After the complete transfer of the liquid to be treated into the circuit, bag 407 containing the buffer liquid is connected via connector 507 to connector 11G. This buffer liquid is then introduced into the transfer section 13A thanks to the transfer pump 403 in order to push the liquid to be treated towards the conduit 13B in such a way that all that liquid can be filtered and recovered. The conduit 13A is then isolated from the conduit 13B by closing the valve 125A.
    [0221] Once the transfer has been made, valves 125E and 125D are opened, the liquid to be treated is made to flow through the flow pump 404, in the sub-circuit formed by the supply section. After passing the liquid through the tangential filter 401, the retained material is returned to the supply container 400 while the filtrate is evacuated via conduits 13J and 131 to be collected in the disposal containers 411 and 412.
    [0222] The operation of making the liquid to be treated flow into the 401 filter is continued until the liquid reaches the desired concentration.
    [0223] The collection of the filtered liquid is then carried out in two successive sub-steps.
    [0224] The first sub-step consists of recovering the filtered liquid contained in the filtration section formed by a section of the 13B conduit and in the 401 filter.
    [0225] For this, valve 125B is closed while valve 125A is opened in order to put the transfer and filtration sections in communication, and isolate them from the filling section formed by the other section of the 13B conduit.
    [0226] In parallel, the 125D valve is closed while the 125F and 125E valves are opened in order to connect the filtration section formed by a section of the conduit 13B and the collection section formed by the conduit 13H, and to isolate the same as in the supply section.
    [0227] The female connector 11J is connected to the male connector 510 of the collection container 410.
    [0228] Then buffer liquid is transported to the transfer section (conduit 13A) by means of transfer pump 403 in order to transfer, via the collection section (conduit 13H), the buffer liquid, and, with this, the rest of the filtered liquid contained in the filtration section (portion of the conduit 13B and conduit 13C) and in the filter 401 for the collection container 410.
    [0229] The second sub-step consists of collecting the filtered liquid contained in the filling (duct portion 13B) and supply (duct portion 13C) sections, and in the supply container 400.
    [0230] For this purpose, valve 125C is closed while valve 125B is opened in order to communicate the transfer (conduit 13A) and filling (conduit portion 13B) sections, and isolate them from the filtration section (another portion of conduit 13B and conduit 13C).
    [0231] In parallel, valve 125E is closed, while valve 125D is opened in order to communicate the supply sections (conduit section 13C) and collect (conduit 13H) sections, and isolate them from the filtration (another section of conduit 13B and another section of conduit 13C).
    [0232] Buffering liquid is then transported into the transfer section (conduit 13A) by means of transfer pump 403 in order to transfer the filtered liquid contained in the filling section (another section of conduit 13B) into the interior of the supply container 400.
    [0233] The flow pump 404 then allows liquid to be brought from container 400 to collection container 410, via the supply and collection sections.
    [0234] In a non-illustrated variant, the pumps are diaphragm-type, rather than peristaltic.
    [0235] In a variant not shown, the dimensions of bag 10 do not coincide with those of the surfaces of layers 16 and 17, being larger or smaller.
    [0236] It should be noted more generally that the invention is not limited to the described and represented examples.
    权利要求:
    Claims (11)
    [0001]
    1. Bag for a circuit of an installation for the treatment of a biological liquid by means of tangential filtration, characterized by the fact that it comprises: - a plurality of connectors (11A-11P) and a network (12) to transport liquid between said connectors (11A-11P), said transport network (12) being formed by a plurality of conduits (13A-13K); and - two flexible films (65, 66) attached to each other, said conduits (13A-13K) being formed between the two said flexible films (65, 66); a first conduit (13C) extending longitudinally between a flow pump connector (11C) emerging on a first side (68) of said bag and a tangential filter connector (11M) emerging on a second side (69) said bag which is a side opposite to said first side (68); a second conduit (13B) extending longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68) of said bag, and another tangential filter connector ( 11N) emerging on said second side (69) of said bag which is a side opposite to said first side (68); a third conduit (13H) extending from a second side of said conduit (13C), which is a side opposite to said first side of said conduit (13C), starting from a collection container connector (11J), until into said first conduit (13C); and a fourth conduit (13A) extending from the first side of said conduit (13C), starting from a transfer pump connector (11A), until it enters said second conduit (13B); whereby said bag is configured so that the liquid to be treated passes into said bag (10) via said fourth conduit (13A), then passes to a supply container via said second conduit (13B), then passes to the tangential filter through the action of a flow pump via said first conduit (13C), with a first treated liquid passing from the tangential filter to the supply vessel via said second conduit (13B) and a second treated liquid passes from the tangential filter to a collection container via said first conduit (13C).
    [0002]
    2. Bag according to claim 1, characterized by the fact that it comprises a fifth conduit (13K) connected to a transfer pump connector (11E), and a sixth conduit (13E) which extends from a source container connector (11F) until it enters the fifth conduit (13K).
    [0003]
    3. Bag according to claim 2, characterized by the fact that it comprises at least one seventh conduit (13F, 13G) that extends from a buffer and / or cleaning container connector (11G, 11H) until it enters the fifth conduit (13K).
    [0004]
    Bag according to one of claims 2 and 3, characterized in that it comprises an eighth conduit (13D) that extends between an air filter connector (11 D) and a rinsing container connector (111), said fifth conduit (13K) entering said eighth conduit (13D).
    [0005]
    Bag according to any one of claims 1 to 4, characterized in that it comprises at least a ninth conduit (131, 13J) that extends between a tangential filter connector (11L, 110) and a container connector discard (11K, 11P).
    [0006]
    6. Device for an installation for the treatment of biological liquid by means of tangential filtration, characterized by the fact that it comprises a circuit (8) comprising: - a pocket (10), as defined in claim 1, provided with a plurality of connectors (11A-11P) and a network (12) for transporting liquid between said connectors (11A-11P), said transport network (12) being formed by a plurality of conduits (13A-13K), the bag ( 10) further comprising two flexible films (65, 66) attached to each other, said conduits (13A-13K) being formed between said flexible films (65, 66); - a press (9) comprising a first layer (16) and a second layer (17) mounted on said first layer (16), said first layer (16) and said second layer (17) cooperating with said bag (10) to form the conduits (13A-13K) of said transport network (12) between said flexible films (65, 66), by means of clamping said bag (10) between said first layer (16 ) and said second layer (17); and - a plurality of valves (125A-N); a first conduit (13C) extending longitudinally between a flow pump connector (11C) emerging on a first side (68) of said bag and a tangential filter connector (11M) emerging on a second side (69) said bag which is a side opposite to said first side (68); a second conduit (13B) extending longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68) of said bag, and another tangential filter connector ( 11 N) emerging on said second side (69) of said bag which is a side opposite to said first side (68); a third conduit (13H) extending from a second side of said conduit (13C), which is a side opposite to said first side of said conduit (13C), starting from a collection container connector (11J), until into said first conduit (13C); a fourth conduit (13A) extending from the first side of said conduit (13C), starting from a transfer pump connector (11A), until it enters said second conduit (13B); and at least one first valve (125D, 125E) which is located in said first conduit (13C), at least a second valve (125B, 125C) which is located in said second conduit (13B), a third valve (125F ) which is located in said third conduit (13H), and a fourth valve (125A) which is located in said fourth conduit (13A).
    [0007]
    7. Device according to claim 6, characterized in that the bag (10) comprises a fifth conduit (13K) connected to a transfer pump connector (11E), and a sixth conduit (13E) extending from a source container connector (11F) until it enters said fifth conduit (13K), and the device comprises a fifth valve (125H) located in said fifth conduit (13K) and a sixth valve (1251) located in said sixth conduit ( 13E).
    [0008]
    8. Device according to claim 7, characterized by the fact that the bag (10) comprises at least one seventh conduit (13F, 13G) extending from a buffer and / or cleaning container connector (11G, 11H ) until it enters said fifth conduit (13K), and the device comprises at least one seventh valve (125J, 125K) located in said seventh conduit (13F, 13G).
    [0009]
    Device according to one of claims 7 and 8, characterized in that the bag comprises an eighth conduit (13D) extending between an air filter connector (11 D) and a rinsing container connector (111 ), said fifth conduit (13K) entering said eighth conduit (13D), and the device comprising at least one eighth valve (125G, 125L) located in said eighth conduit (13D).
    [0010]
    Device according to any one of claims 6 to 9, characterized in that the bag comprises at least one ninth conduit (131, 13J) that extends between a tangential filter connector (11L, 110) and a disposal container (11K, 11P), and the device comprises at least one ninth valve (125M, 125N) located in said ninth conduit (131, 13J).
    [0011]
    Device according to any one of claims 6 to 10, characterized in that it comprises a pressure sensor (126A-D) located in at least one said conduit (13A, 13B, 13C, 13J).
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012027174B1|2020-10-27|bag for a circuit of a biological liquid treatment plant and device for a biological liquid treatment plant by means of tangential filtration
    BR112012030481B1|2020-12-29|bag for a circuit of a biological liquid treatment plant
    JP2013530754A5|2014-06-26|
    ES2773328T3|2020-07-10|Device for a biological liquid treatment circuit
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    CN101287513B|2013-04-03|A burette
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    US5562882A|1996-10-08|Sterile liquid barrier transfer coupling
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    同族专利:
    公开号 | 公开日
    EP2585199B1|2016-12-07|
    KR20130031352A|2013-03-28|
    SG184884A1|2012-11-29|
    CN102933287A|2013-02-13|
    ES2618429T3|2017-06-21|
    US9174171B2|2015-11-03|
    CN102933287B|2016-01-20|
    FR2961713B1|2012-08-10|
    KR101502247B1|2015-03-12|
    JP2013530754A|2013-08-01|
    FR2961713A1|2011-12-30|
    WO2011161609A1|2011-12-29|
    BR112012027174A2|2016-07-19|
    US20130240065A1|2013-09-19|
    WO2011161609A8|2012-03-01|
    US9259687B2|2016-02-16|
    US20120160342A1|2012-06-28|
    JP5653515B2|2015-01-14|
    EP2585199A1|2013-05-01|
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    法律状态:
    2018-04-10| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-01-08| B25G| Requested change of headquarter approved|Owner name: EMD MILLIPORE CORPORATION (US) |
    2019-02-19| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|
    2019-12-10| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2020-04-07| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-10-27| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1055025A|FR2961713B1|2010-06-23|2010-06-23|POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY|
    FR1055025|2010-06-23|
    PCT/IB2011/052676|WO2011161609A1|2010-06-23|2011-06-20|A bag for a circuit of a biological liquid treatment installation|
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