detergent composition and composition

专利摘要:
DETERGENT FOR WASHING CLOTHES. The present invention provides a synergistic composition such as a synergistic detergent composition for use, for example, in disinfection and cleaning.
公开号:BR112012024553B1
申请号:R112012024553-8
申请日:2011-03-25
公开日:2021-03-02
发明作者:Per Bendix Jeppesen；Dan Monster Nielsen；Allan Korsgaard Poulsen
申请人:Liquid Vanity Aps；
IPC主号:

专利说明:

Field of invention
[001] The present invention relates to a laundry detergent composition, preferably a delicate laundry detergent, comprising one or more biocidal compounds for washing textile articles and materials, where low temperature washing is desired at the same time. in which it obtains a biocidal effect, such as, for example, lingerie and underwear. Background of the invention
[002] When washing clothes entirely or in part made of delicate natural fabrics such as silk or wool, there may be a conflict between the desire to protect and care for the fabrics and the desire to obtain clean clothing. This can be especially relevant when the clothes in question are like lingerie or underwear.
[003] Traditionally, underwear, bed sheets or tea towels have been washed at temperatures of 60 or 95 ° C, to obtain clean washing both visually and hygienically. Over the years, the laundry detergent product has been developed that comprises enzymes, such as proteases, amylases, lipases and cellulases; these laundry detergents are marketed for washing at lower temperatures such as 30 or 40 ° C as enzymes assist in the washing process. Recently, low temperature detergents have been developed that can be used at temperatures as low as 15-20 ° C, these contain recently developed enzymes assisting the washing process.
[004] In the specific case of silk and wool textile articles, the natural polymer on which the textile fiber is based is a protein and thus susceptible to degradation by the enzyme. In reality, depending on the enzyme and washing conditions, there is a real risk that the tissues will gradually be eaten by the enzymes. Enzyme-based detergents are not recommended for textile articles containing wool and silk.
[005] The presence of microorganisms in textile articles or other materials can pose a health risk, the Danish National Consumer Agency has stated that in certain cases it is necessary to wash clothes at 95 ° C. This is, for example, in the case of infectious diseases, in cases with particularly dirty textile items, such as diapers, and when washing textile items that comprise sources of infection. Such sources of infection can be feces, urine, blood, body fluids, etc. the temperature of 95 ° C is to ensure the elimination of such sources of infection, which modern enzyme-containing laundry detergents suitable for washing, for example, at 40 ° C do not guarantee.
[006] There has also recently been an increased focus on the possibility of cross-contamination from one laundry batch to the next. If, for example, one person used a washing machine, for example, at 40 ° C for textile articles containing a source of infection, and the next person uses the same washing machine for washing at low temperature too, for example, delicate textile items, such as lingerie at 30 ° C, microorganisms may be transferred from one laundry batch to the next. This is, for example, a risk in apartment blocks with common laundries, in launderettes, or in communal laundries in a nursing home or hospital with a majority of sick or weak people susceptible to either providing the infection or easily acquiring an infection. cross-contaminated clothing, bedding or towels washed in a communal laundry.
[007] Therefore, to obtain a satisfactory washing of clothes, for example, lingerie or underwear, it is necessary to wash at least 60 ° C. However, manufacturers of lingerie, or other delicate textile items, provide care labels determining a wash temperature of 40 ° C or less. The lack of washing at a sufficiently high temperature causes the aforementioned problems of cross-contamination or a reinfection in the continued reality of the same person. This may be, for example, the case with genital fungal infections that in some may become chronic, or vaginitis in general, such as, for example, both candidiasis and bacterial vaginosis. Sources of infection are, for example, bacteria (such as, for example, Streptococcus, Staphilococcus aureus, Gardnerella, Escherichia coli, bacterioids, or mycoplasma), fungi (such as, for example, Candida albicans, or viruses (such as, for example, HIV -1, Hepatitis B or Hepatitis C).
[008] In addition to being sensitive to enzymes, wool and silk textile articles also need to be washed at low temperatures, for example, 30 or 40 ° C and in a gentle cycle in a washing machine or gently by hand washing, to avoid excessive shrinkage or deformation. It is also recommended to avoid highly alkaline pH. Therefore, a washing detergent for delicate fabrics, such as wool and silk, needs to be free of enzymes, less alkaline than traditional washing detergents and suitable for washing at low temperatures.
[009] The aforementioned problems with cross-contamination or reinfection are therefore especially relevant for such delicate textile articles. Therefore, unless clothing items are only slightly soiled and there is no risk of infectious sources, there is a conflict between care for the fabric and obtaining clean clothing. When items of clothing are such as lingerie or underwear there is a special need for a delicate washing detergent that in addition to washing and caring for the fabric can also remove any unwanted bacteria, fungi or viruses.
[0010] Due to the chemical nature of both laundry detergent ingredients and biocidal compounds, it is well known that not all combinations of such ingredients can provide a stable and effective composition that provides both detergent and biocidal properties.
[0011] Another well-known problem in the field of cleaning products is that very high concentrations of products comprising a single biocide are necessary and that the target microorganisms are likely to become resistant to the biocide used after long-term treatment. Summary of the invention
[0012] The inventors of the present invention have now surprisingly succeeded in identifying a biocidal composition comprising one or more biocides having a synergistic effect thereby minimizing the concentration required to obtain a biocidal effect. The use of a 2-component biocidal composition can also reduce the risk that the microorganisms to be targeted will become resistant to the biocidal composition.
[0013] The inventors of the present invention have additionally surprisingly succeeded in providing stable detergent compositions comprising one or more biocides and one or more surfactants.
[0014] The biocidal composition according to the invention has many different uses, one of which is as a wash clothes composition. Other non-limiting uses for a biocidal composition according to the invention are, for example, in:. disinfectants and biocidal products in general as well as biocidal human hygiene products; disinfectants in the private and public health areas and other biocidal products; biocidal veterinary hygiene products; and feed and food disinfectants and drinking water disinfectants; . condoms as canned condoms; film condoms; wooden condoms; condoms made of fiber, leather, rubber and polymerized materials; masonry condoms; condoms for processing and liquid cooling systems; slimicides; textile articles and metallurgical fluid preservatives; . pest control as in rodenticides; avicides; molluscicides; pesticides; insecticides; acaricides and products to control other arthropods; and repellents and attraction agents; . other biocidal products such as preservatives for food or inputs; anti-fouling products, taxidermist and embalming fluids; and control of other vertebrates; . parasitic insects as in or in domestic animals, farm animals; . seaweed; and . products for use, for example, in spas, swimming pools and the like.
[0015] In another embodiment the present invention relates to a washing detergent composition, as preferably a delicate washing detergent composition, comprising one or more biocidal compounds. The composition is preferably for washing textile articles or materials made entirely or in part of silk or wool, or other enzyme sensitive materials such as natural hair.
[0016] The composition is additionally preferably a liquid washing detergent, and may comprise one or more biocidal compounds selected from the group consisting of a PQ polymer, poly-hydrochloride (hexamethylenebiguanide), Akacid forte®, Akacid®, N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (Bardap-26), povidone-iodine (PVP-iodine, Betadine ™), benzyl amyldimethyl C12-18 ammonium chlorides, alkyl ammonium chlorides benzyl C12C14 dimethyl, alkyl [(ethylphenyl) methyl] ammonium chlorides C12-13 dimethyl (ADBAC), d-C8-10 alkylldimethyl ammonium chloride (DDAC) and octenidine dihydrochloride; or acceptable toxicological salts or solvates thereof.
[0017] In another preferred embodiment of the invention one or more biocidal compounds is a synergistic combination that can be used as such or as part of a composition also comprising one or more surfactants.
[0018] In a preferred embodiment of the invention one or more biocidal compounds is a synergistic combination of one or more biocidal compounds, providing an increased biocidal effect compared to the use of biocidal compounds alone at the same total concentration. In an especially preferred embodiment of the invention the biocidal compound is a mixture of Akacid Forte® and Bardap-26. Detailed description of the invention
[0019] One aspect of the invention relates to a biocidal composition, which has many different uses, one of which is as a laundry composition. Other non-limiting uses for a biocidal composition according to the invention are, for example, in: disinfectants and biocidal products in general as in human hygiene biocidal products; disinfectants in the private and public health areas and other biocidal products; biocidal veterinary hygiene products; and feed and food disinfectants and drinking water disinfectants; condoms as canned condoms; film condoms; wooden condoms; condoms made of fiber, leather, rubber and polymerized materials; masonry condoms; condoms for processing and liquid cooling systems; slimicides; textile articles and metallurgical fluid preservatives; pest control as in rodenticides; avicides; molluscicides; pesticides; insecticides; acaricides and products to control other arthropods; and repellents and attraction agents; other biocidal products such as preservatives for food or inputs; anti-fouling products, taxidermist and embalming fluids; and control of other vertebrates; parasitic insects as in or in domestic animals, farm animals; seaweed; and products for use, for example, in spas, swimming pools and the like.
[0020] In one embodiment of the invention, the biocidal composition of the invention comprises at least two biocides having a synergistic effect. In one embodiment, the biocidal composition of the invention does not comprise a surfactant. In another embodiment of the invention, the biocidal composition of the invention comprises one or more surfactants.
[0021] The inventors of the present invention have surprisingly succeeded in defining the optimal biocidal detergent composition. Therefore, the inventors find that stability problems of biocidal compositions comprising one or more surfactants were due to micelle formation and that such micelle formation should be avoided by carefully selecting a nonionic or monovalent cationic surfactant. The inventors have found that the most preferred detergent composition comprises surfactants such as nonionic or monovalent cationic surfactants as of the general formula R (OCH2CH2) xOH in which: R is C7-20 alkyl so the alkyl has 7-20 carbon atoms in which R can be optionally substituted as defined here; and . x is 2-12, so the polyethylene glycol comprises 2-12 repetitions of OCH2CH2.
[0022] Micelle formation leads to biocide encapsulation thereby preventing the detergent composition comprising one or more biocides from having an efficient biocidal effect. Therefore, by preventing micelle formation, an efficient biocidal effect of the detergent composition comprising one or more biocides can be maintained.
[0023] The inventors of the present invention have also realized that micelle formation can be avoided and thus stable detergent compositions can be obtained if the critical micelle concentration of one or more biocides (CMC (biocide)) is higher than the minimum inhibitory concentration of one or more biocides (MIC (biocide)).
[0024] The inventors of the present invention have also realized that micelle formation can be avoided and thus stable detergent compositions can be obtained if the critical micelle concentration of the detergent composition (CMC (detergent)) is higher than the concentration minimal inhibitor of one or more biocides (MIC (biocide)).
[0025] The inventors have also succeeded in identifying a surprisingly efficient biocidal synergistic composition comprising two or more biocides. When comprised in a biocidal detergent composition, convincing results have been obtained in which the biocidal effect of the biocidal composition comprising two or more biocides is not influenced by the presence of surfactants in the biocidal detergent composition.
[0026] The inventors of the present invention have been successful in providing biocidal detergent compositions that reduce the total amount of fungus with a factor of 105 or more. In one embodiment of the invention, the total amount of fungus was even reduced with a factor of 106. The inventors of the present invention have further succeeded in providing biocidal detergent compositions by reducing the total amount of bacteria with a factor of 107 or more. The convincing reduction in fungus and bacteria thus obtained was highly surprising.
[0027] The same reduction in bacterial growth or yeast growth was obtained regardless of the soap tested, however only as long as the soap comprises a surfactant of the formula R (OCH2CH2) xOH in which: R is C7-20 alkyl so the alkyl it has 7-20 carbon atoms where R can be optionally substituted as defined here; and . x is 2-12, so the polyethylene glycol comprises 2-12 repetitions of OCH2CH2.
[0028] It has also been shown that a biocidal detergent composition in which the surfactant comprises C18 alkyl and in which one or more surfactants in addition to (OCH2CH2) xOH also comprises (OCH2 CH2CH2) x only reduced the growth of microorganisms insignificantly in which only a reduction 102 was obtained.
[0029] One aspect of the invention relates to the use of a biocidal composition according to the invention, with or without detergent, for example, in: disinfectants and biocidal products in general as in human hygiene biocidal products; disinfectants in the private and public health areas and other biocidal products; biocidal veterinary hygiene products; and feed and food disinfectants and drinking water disinfectants; condoms as canned condoms; film condoms; wooden condoms; condoms made of fiber, leather, rubber and polymerized materials; masonry condoms; condoms for processing and liquid cooling systems; slimicides; textile articles and metallurgical fluid preservatives; pest control as in rodenticides; avicides; molluscicides; pesticides; insecticides; acaricides and products to control other arthropods; and repellents and attraction agents; other biocidal products such as preservatives for food or inputs; anti-fouling products, taxidermist and embalming fluids; and control of other vertebrates; parasitic insects as in or in domestic animals, farm animals; seaweed; and products for use, for example, in spas, swimming pools and the like.
[0030] One aspect of the invention relates to a product that is a biocidal composition as such, that is, a composition that does not comprise detergent, in a preferred embodiment, the biocidal composition without detergent comprises two or more biocides according to the invention , biocides having a synergistic effect. In a specific modality, the product is selected from the group consisting of disinfectants and biocidal products in general. In another specific modality, the product is a condom. In yet another specific modality, the product is a product for pest control. In yet another modality, the product is selected from the group consisting of other biocidal products. In yet another specific modality, the product is a product for the treatment of parasitic insects. In yet another specific modality, the product is a product for algae control. In yet another specific modality, the product is for use for disinfection, such as for disinfecting spas, swimming pools and the like.
[0031] One aspect of the present invention relates to a washing detergent composition, as preferably a delicate washing detergent composition, comprising one or more biocides.
[0032] It is an object of the present invention to provide a laundry detergent composition that can provide, in addition to a detergent effect, a biocidal effect to eliminate or reduce the presence of microorganisms in textile articles or materials that are not suitable for washing at temperatures 60 ° C or 95 ° C.
[0033] It is additionally an objective of the present invention to provide a washing detergent that can provide, in addition to a detergent effect, a biocidal effect to eliminate or reduce the presence of microorganisms in textile articles or materials, such as bed linen or towels. hospitals or nursing homes, which could normally be washed at elevated temperatures of 95 ° C, to eliminate sources of infection, but due to environmental considerations or practical considerations, such as power outages, machinery, etc., for example, in countries in development, it should preferably be washed at lower temperatures.
[0034] The term "washing detergent", as used here, is intended to mean compositions for washing textile articles or materials (for example, clothes, towels, other household textile articles or wigs) include both solid and liquid detergent compositions, such as soap powder and washing powder, liquid, unless mentioned otherwise. The term does not include dishwashing detergents or other household cleaning agents.
[0035] To provide a consumer friendly product for easy use the washing detergent of the present invention is preferably an all-in-one product. Therefore, the active ingredients for washing and one or more biocidal compounds are preferably in the same formulation, as opposed to a biocidal composition that is added before, during or after the actual washing process. An all-in-one product provides several advantages, for example, it is easy to use and safe from failure, that is, the product is used as a common washing detergent and does not require knowledge, for example, soaking time, or incompatibility between product and detergents.
[0036] The terms “delicate wash”, “fine fabric detergent” and “delicate washing detergent”, as used here, are intended to mean a washing detergent for washing textile articles or delicate materials, such as lingerie , underwear, wool underwear, thermal underwear, socks, pantyhose, natural and / or synthetic wigs, bedding, comforters or textile items or related clothing, made entirely or in part of silk, wool or other fibers natural (like hair and feathers) sensitive to traditional powdered soaps or liquid washing products containing enzymes. Unless otherwise mentioned, delicate washing includes both solid and liquid compositions. In a specific embodiment of the present invention the washing detergent, as a delicate washing detergent, does not comprise enzymes. A preferred embodiment of the present invention relates to a delicate washing detergent; more preferably a delicate laundry detergent for washing textile articles or materials made entirely or in part from silk, wool, hair, feathers or other natural fibers; even more preferably a delicate washing detergent for washing textile articles or materials made entirely or in part of silk, wool, hair or feathers; and even more preferably a delicate washing detergent for washing textile articles or materials made entirely or in part of silk or wool.
[0037] In addition to being sensitive to enzymes, wool, thirst and other natural materials need to be washed at low temperatures. The washing detergent composition, and especially the delicate washing detergent composition, according to the present invention may preferably be suitable for washing at low temperatures in the range of approximately 5 ° C to approximately 40 ° C, more preferably approximately 10 ° C to approximately 40 ° C, for example, from approximately 15 ° C to approximately 40 ° C, from approximately 20 ° C to approximately 40 ° c, from approximately 20 ° c to approximately 40 ° C, from approximately 15 ° C at approximately 30 ° C, approximately 20 ° C or approximately 30 ° C.
[0038] In an embodiment of the invention, the washing detergent composition and especially the delicate washing detergent composition according to the present invention may preferably be suitable for washing at low temperatures in the range of approximately 20 ° C to approximately 40 ° C, as approximately 25 ° C to approximately 35 ° C. in a specific embodiment of the invention, the washing detergent composition, and especially the delicate washing detergent composition, according to the present invention may preferably be suitable for washing at low temperatures in the range of approximately 30 ° C. when the term "suitable for washing" at a specified temperature is used here in relation to the laundry detergent composition, it is meant to mean that the composition is effective at that temperature, both with regard to detergent properties and biocidal properties.
[0039] In one embodiment of the present invention, the laundry detergent composition is for use in washing clothes or textile articles considered to be a source of infection, such as preferably washing hospital clothes or nursing homes. In the embodiment it is preferred to use one or more biocides that especially eliminate E. coli entirely, that is, it reduces the number of microorganisms by at least 106, more preferably by 107 or more. The present inventors have surprisingly found that using a mixture of the biocides Bardap-26 and Akacid Forte® a synergistic effect is obtained at low concentrations and even at low temperature, that is, 30 ° C. Thereby eliminating the need to wash at least 75 ° C to achieve the same result with traditional laundry detergent compositions. See, for example, S. Fijan and others for a study of temperature, time and detergent needed to reduce / eliminate representative fungi and bacteria (Fijan and others: Antimicrobial disinfection effect of a laundering procedure for hospital textiles against various indicator bacteria and fungi using different substrates for simulating human excrements; Diagnostic Microbiology and Infectious Disease; 57 (2007) 251-257).
[0040] The terms "washing powder" and "solid detergent" as used here, are intended to mean a washing detergent in solid, granular or powder form, and these terms can be used interchangeably.
[0041] The washing detergent according to the present invention can be suitable for machine washing as well as hand washing. Alternatively, the detergent composition may be specifically suitable for machine washing or specifically suitable for hand washing.
[0042] The terms "washing liquid", "washing liquid detergent" and "washing liquid", as used here, are intended to mean a washing detergent in liquid form, as opposed to a solid detergent, and these terms can be used interchangeably. In a preferred embodiment of the present invention the washing detergent composition, such as a delicate washing detergent, is a liquid detergent composition.
[0043] The terms "biocide" or biocidal compound ", as used here, are intended to mean a compound that eliminates or significantly reduces the growth of microorganisms. The terms can be used interchangeably here and include, unless mentioned otherwise, antimicrobial compounds, such as, for example, germicides, antibiotics, antibacterials, antivirals, antifungals, antiprotozoans and antiparasites. The microorganisms to be affected by these compounds can preferably be bacteria, viruses or fungi; more preferably bacteria and fungi. It is an objective of the present invention to provide a washing composition that can eliminate or significantly reduce the growth of microorganisms selected from the group consisting of bacteria (such as, for example, Streptococcus, Gardnerella, Staphilococcus aureus, Escherichia coli, bacterioids or mycoplasma), fungi (such as, for example, Candida albicans), and viruses (such as, for example, HIV-1, hepatitis B or hepatitis C). the biocidal effect of a washing detergent according to the present invention can, for example, be tested against a group of representative microorganisms such as, for example, Staphilococcus aureus, Escherichia coli and Candida albicans. Biocides
[0044] One or more biocides to be used in the present invention can be one or more biocides approved for human hygiene products and approved for use in public health and private area products, since the present invention must be used in washing of private household clothing and at the same time can come into contact with the person wearing the clothing having been washed with a composition according to the present invention.
[0045] Such approved biocides may depend on the geographical region and thus on the authority in charge of the approval procedure. For Euro pa it is currently the European Commission and listings of biocides can be found in the Biocidal Products Directive 98/8 / EC. For some geographic regions no list of approved biocides exists, in such cases there may instead be a negative list of biocides that may not be used. For such geographic regions, the biocides to be used in the present invention may be a biocide not present in a negative list. In addition to being approved, or not being present on a negative list, it is important that biocides are compatible with washing detergent. In one embodiment of the invention the biocide is not benzalkonium chloride.
[0046] It is additionally an objective of the present invention to provide a washing detergent composition, in which one or more biocides are two or more biocides which together provide a synergistic effect on the elimination or reduction of microorganisms. By using two different biocidal compounds, where one, for example, is especially effective for bacteria and the other is especially effective for fungi, a synergistic effect can be obtained with respect to the total biocidal activity. Thereby obtaining a number of advantages of the composition according to the invention, such as, for example, a reduction in the amount of total biocide present in the composition, and at the same time it obtains a superior effect on the total amount of microorganisms.
[0047] In one embodiment of the present invention the total amount of microorganisms, preferably bacteria and fungi, is reduced by at least 50%, preferably at least 60%, more preferably at least 70%, even more preferably at least 80%, still more preferably at least 90%, and more preferably at least 99.9%. The reduction of microorganisms by the compositions of the present invention can preferably be determined according to the test described in the examples (see example 4A and 4B). the reduction in the total amount of microorganisms can be additionally expressed as a reduction in log units. It is an object of the present invention to use one or more biocidal compounds that provide a reduction in fungus and bacteria of at least 3 and 4 log units, respectively, that is, a reduction of 103 and 104, preferably at least 4 and 5 log units. (104 and 105), respectively; more preferably at least 5 and 6 log units (105 and 106), respectively; and even more preferably at least 6 and 7 log units (106 and 107), respectively.
[0048] Under current practice, to accept a product as having a disinfecting capacity a reduction of at least 105 (5 log units) of bacteria or at least 104 (4 log units) of yeast reduction must be demonstrated (EN 1276; 1997, DS / EN 1275: 2005).
[0049] The biocidal effect can preferably be further tested and defined as the effect on the following group of microorganisms: Escherichia coli, Staphilococcus aureus, Pseudomonas aeruginosa, and Candida albicans; or alternatively from the following group of microorganisms Escherichia coli, Staphilococcus aureus, and Candida albicans.
[0050] Escherichia coli was chosen to represent a gram negative fecal bacterium; Staphilococcus aureus was chosen to represent a gram-positive, heat-tolerant bacterium; Pseudomonas aeruginosa was chosen to represent a bacterium that causes diseases that in some cases are difficult to treat; and Candida albicans represents the presence of fungi.
[0051] In one embodiment of the present invention one or more biocides is effective for reducing Escherichia coli, Staphilococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
[0052] In a specific embodiment of the invention, one or more biocides according to the invention have a minimum inhibitory concentration (MIC) of 1200 ppm or less. . In one embodiment, one or more biocides have a MIC of 700 ppm or less. In another embodiment, one or more biocides have a MIC of 200 ppm or less. In yet another embodiment, one or more biocides have a MIC of 160 ppm or less. In yet another embodiment, one or more biocides have a MIC of 120 ppm or less. In yet another embodiment, one or more biocides have a MIC of 80 ppm or less. In a preferred embodiment, one or more biocides have a MIC of 40 ppm or less.
[0053] In a composition mode with or without detergent, one or more biocides are comprised in a total amount of approximately 100-5000 ppm. In one embodiment, one or more biocides are comprised in a total amount of approximately 100-2500 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 100-1000 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 150-800 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 200-700 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 20-100 ppm; and in one embodiment one or more biocides are comprised in a total amount of approximately 250-600 ppm. Alternatively, one or more biocides can be comprised in a total amount of less than 250 ppm, such as 250-200 ppm. In one embodiment, one or more biocides can be comprised in a total amount less than 150 as less than 100 ppm.
[0054] In one embodiment of the present invention one or more biocides are selected from the group consisting of: a PQ polymer, such as, for example, polymeric quats, polymer of N chloride, N-dimethyl-2-hydroxy propyl ammonium (Barquat ® PQ), for example, by Lonza or The Polyqat Task Force; a polymer of polymeric biguanide, such as, for example, PHMB, poly (hexamethylene biguanide) hydrochloride, poly (hexamethylenguanide) chloride Akacid forte®), poly (oxyalkylnoguanidine) hydrochloride (Akacid®; an alkyl ammonium salt of dialkyl and methyl oxyethylene, such as N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (Bardap-26) or N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate; iodine (PVP-iodine, Betadine ™); a salt of alkyl dimethyl benzyl ammonium or dialkyl methyl benzyl ammonium salt, such as, for example, benzyl dimethyl ammonium coconut chlorides or dichoco benzyl methyl ammonium chlorides with predominantly alkyl chlorides C12-18 benzyl, C12-14 alkyl dimethyl ammonium, C12-14 alkyl benzyl ammonium chlorides, or C12-13-alkyl [(ethylphenyl) methyl] dimethyl ammonium chlorides (ADBAC); a dialkyl dimethyl ammonium salt, coom, for example, di-C8-10 alkyldimethyl ammonium chloride, that is, didecyl dimethyl ammonium chloride, di octyl dimethyl ammonium, or octyl decyl dimethyl ammonium chloride (DDAC); and a bispiridine, such as, for example, octenidine dichloridate (see, Slee et al., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1983), 23 (4), page 531535, for additional bispiridines), or acceptable toxicological salts or solvates thereof .
[0055] In one embodiment of the present invention one or more biocides is selected from the group consisting of a PQ polymer; a polymer of biguanide polymer; an alkyl oxyethylene methyl ammonium salt; dialkyl oxyethylene methyl ammonium salt; povidone-iodine; an alkyl dimethyl benzyl ammonium salt; dialkyl methyl benzyl ammonium salt; a dialkyl dimethyl ammonium salt; and a bispiridine; or acceptable toxicological salts or solvates thereof.
[0056] In a more specific embodiment of the present invention one or more biocides is a polymer of polymeric biguanide, or acceptable toxicological salts or solvates thereof; and selected from the group consisting of PHMB, poly (hexamethylenebiguanide) hydrochloride, Akacid forte®, and Akacid®, or other acceptable toxic salts or solvates thereof. In an even more specific embodiment of the present invention, one or more biocides is selected from the group consisting of Akacid forte® and Akacid® or mixtures thereof.
[0057] In another specific embodiment of the present invention one of one or more biocides is an alkyl or dialkyl salt oxyethylene methyl ammonium, and selected from the group consisting of N, N-didecyl-N-methyl-poly (oxyethyl) propionate ammonium (eg, Bardap-26) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium lactate. In an even more specific embodiment of the present invention one of one or more biocides is Bardap-26.
[0058] In another specific embodiment of the present invention one or more biocides are selected from the group consisting of polymeric alkoxy (an / en / in) salts (polymeric methyl ammonium), dialq salts (an / en / in) Il methyl ammonium oxyethylene and biguanide polymers; or other acceptable toxicological salts or solvates thereof.
[0059] In another specific embodiment of the present invention one or more biocides is an alkyl oxyethylene methyl ammonium salt or dialkyl oxyethylene methyl ammonium salt such as N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (e.g. Bardap 26). The molar weight of the active ingredient (CAS No. 94667-33-1) in Bardap-26 is approximately 454 g / mol.
[0060] In another specific embodiment of the present invention one or more biocides is a poly- (hexamethylene-guanidium chloride) (e.g., strong Akacid) or other acceptable toxicological salts or solvates thereof. The molar weight of the active ingredient (CAS No. 57028-96-3) in Akacid Forte is approximately 1000 g / mol.
[0061] In another specific embodiment of the present invention one or more biocides is a mixture of poly- (hexamethylene-guanide chloride) (for example, Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl ) ammonium propionate (for example, Bardap 26). In one embodiment of the invention, one or more biocides is a mixture of poly- (hexamethylene-guanidium chloride) (for example, Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate example, Badap 26) in a ratio of 0.5 - 1.5: 1-5 by weight. In another embodiment of the invention, one or more biocides is a mixture of poly- (hexamethylene-guanidium chloride) (for example, Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate example, Bardap 26) in a ratio of 0.8 - 1.2: 2-4 by weight. In yet another embodiment of the invention, one or more biocides is a mixture of poly- (hexamethylene-guanidium chloride) (for example, Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) propionate ammonium (for example, Bardap 26) in a ratio of approximately 1: 2 by weight. In a preferred embodiment of the invention, one or more biocides is a mixture of poly- (hexamethylene-guanidium chloride) (e.g. Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate ( for example, Bardap 26) in a ratio of approximately 1: 1 by weight. In yet another preferred embodiment of the invention, one or more biocides is a mixture of poly- (hexamethylene-guanidium chloride) (e.g., Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (for example, Bardap 26) in a ratio of approximately 1: 3 by weight.
[0062] In an embodiment of the invention, poly- (hexamethylene-guanidium chloride) (for example, Akacid Forte) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (for example, Bardap 26) is p.
[0063] In a preferred embodiment of the present invention one or more biocides is a mixture of poly- (hexamethylene-guanide chloride) (for example, Akacid Forte®) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (for example, Bardap 26), such as in a ratio of approximately 1: 1, 1: 1.25, 1: 1.5, 1: 1.75, 1: 2, 1: 3, 1: 4, 1 : 5, 1.25: 1, 1.5: 1, 1.75: 1, 2: 1, 3: 1, or 4: 1; more preferably a mixture in a ratio of approximately 1: 1, 1: 1.25, 1: 1.5, 1: 1.75, 1: 2, 1: 3, 1.25: 1, 1.5: 1, 1.75: 1, 2: 1, or 3: 1; even more preferably a mixture in a ratio of approximately 1: 1, 1: 1.25, 1: 1.5, 1: 1.75, 1: 2, 1.25: 1, 1.5: 1, 1.75: 1, or 2: 1; even more preferably essentially a one to one mixture of poly- (hexamethylene-guanidium chloride) (eg Akacid Forte®) and N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (eg Bardap-26). It was surprisingly found that this specific combination of biocides provides a synergistic effect in reducing all representative microorganisms Escherichia coli, Staphilococcus aureus and Candida albicans. It is especially interesting that Candida albicans, which by using Akacid Forte alone at a concentration of 120 ppm has not been reduced, and that by using Bardap-26 alone a concentration of 120 ppm has been reduced by ~ 103, can be reduced by> 106 by using a one-to-one mixture at a total concentration of 120 ppm. Similarly, it is interesting that Staphilococcus aureus that by using Akacid Forte alone at a concentration of 120 ppm has not been reduced, and that by using Bardap-26 alone has been reduced by 102-103, it can be reduced by> 106 by using of a mixture of one to one of the two in a total concentration of 120 ppm. In addition, Escherichia coli can be reduced by> 106 by using a one-to-one mixture of Bardap-26 and Akacid Forte in a concentration, for example, 120 ppm, but can only be reduced by 104-105 and ~ 103 , respectively, for the use of biocides alone. See examples 4A and 4B of the present invention for further details.
[0064] In another specific embodiment of the present invention one of one or more biocides is povidone-iodine (PVP-iodine, Betadine ™).
[0065] In another specific embodiment of the present invention one of one or more biocides is an alkyl dimethyl benzyl ammonium salt or a dialkyl methyl benzyl ammonium salt; as selected from the group consisting of benzyl dimethyl ammonium chloride or dichloro benzyl methyl ammonium chloride with alkyl groups predominantly C12-18 benzyl dimethyl ammonium chloride, C12-14, C12-14 alkyl benzyl ammonium chloride, and C12-13-alkyl [(ethylphenyl) methyl] dimethyl ammonium chlorides (ADBAC); more preferably C12-13-alkyl ammonium chlorides [(ethylphenyl) methyl] dimethyl (ADBAC).
[0066] In another specific embodiment of the present invention, one of one or more biocides is. a dialkyl dimethyl ammonium salt, with, for example, di-C8-10 alkyldimethyl ammonium chloride, as one or more selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, and octyl decyl dimethyl chloride ammonium (DDAC).
[0067] In another specific embodiment of the present invention one of one or more healthy biocides. a bispyridine, or acceptable toxicological salts or solvates thereof; such as, for example, one or more bispyridines selected from bispyridines specified in Slee et al., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1983), 23 (4), p. 531-535, as octenidine dihydrochloride.
[0068] In another specific embodiment of the present invention one of one or more biocides is a QP polymer, or acceptable toxicological salts or solvates thereof; as one or more polymeric quats, such as N, N-dimethyl-2-hydroxy propyl ammonium chloride polymer (Barquat® PQ)
[0069] Biocides for use in the present invention may additionally be composed of quaternary ammonium, such as one or more of the following: 1. Monoalkyl trimethyl ammonium salts, wherein the alkyl group, for example, is an alkyl of 6-18 atoms of carbon, preferably 12-14 carbon atoms, and the salt is formed with an appropriate anion that allows easy solubility in water, for example: chloride, bromide, sulfate, acetate, propionate, lactate, citrate, methosulfate and carbonate, preferred examples include ammonium chloride cocotrimethyl C12-14 alkyl; 2. Dialkyl dimethyl ammonium salts, where alkyl groups can be the same or different and contain 6-18 carbon atoms, preferably 8-10 carbon atoms, and the salt is formed with an anion of the type previously described, preferred examples include didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride and octyl decyl dimethyl ammonium chloride; 3. Dimethyl benzyl ammonium salts and dialkyl methyl benzyl ammonium salts, where alkyl groups can be the same or different and contain 6-18 carbon atoms, preferably 8-10 carbon atoms in a dialkyl and 10- 14 carbon atoms in a monoalkyl, and the salt is formed with an anion of the type previously described, preferred examples include benzyl dimethyl ammonium chloride and benzyl methyl ammonium dicoco chloride in which the alkyl groups are predominantly C12-14; 4. Alkyl and dialkyl oxyethylene methyl ammonium salts, where alkyl groups can be the same or different and contain 6-18 carbon atoms, preferably 8-10 carbon atoms in a dialkyl and 10-14 carbon atoms in a monoalkyl , more preferably 10 carbon atoms, and the salt is formed with an anion of the type previously described, preferably propionate or lactate, preferred examples include N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (Bardap 26) or N, N-didecyl-N-methyl-poly (oxyethyl) ammonium lactate; and 5. Polymeric quaternary ammonium compounds in which active quaternary ammonium compounds are chemically grafted onto a polymer backbone.
[0070] In one embodiment of the present invention one or more biocides are selected from the group consisting of N, N-dimethyl-2-hydroxypropyl ammonium chloride polymer (Barquat® PQ), poly (hexamethylene biguanide) hydrochloride, polyl (hexamethylene guanidinium chloride (Akacid forte®, poly (oxyalkylene guanidine hydrochloride) (Akacid®, N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (Bardap 26), povidone-iodine (PVP-iodine , Betadine ™); C12-18 alkyl benzyl dimethyl ammonium chlorides, C12-14 alkyl benzyl ammonium chlorides, C12-13 alkyl ammonium chlorides [(ethylphenyl) methyl] dimethyl (ADBAC), di-C8-10alkyl chloride dimethyl ammonium (DDAC), and octenidine dichloridate, or acceptable toxicological salts or solvates thereof.
[0071] One or more biocides may be present in the composition, according to the present invention in an amount less than 20% by weight, in a range between 0.01% to 15%, as, for example, in a range from 0.01% to 12%, in a range of 0.10% to 10% in a range of 0.10% to 8%, in a range of 0.5% to 8%, in a range of 1% at 8%, in a range of 1% to 6%, or in a range of 1% to 5% by weight. It is an objective of the present invention to reduce the amount of biocide present to meet environmental demands.
[0072] The amount of one or more biocides can additionally be expressed as the amount present during use, that is, when textile articles are under the influence of the washing detergent in an appropriate amount of water. The amount of biocidal compound can be in a range of approximately 200 ppm to approximately 2 ppm, such as, for example, in a range of approximately 200 ppm to approximately 10 ppm or from approximately 200 ppm to approximately 20 ppm, more than approximately 180 ppm at approximately 20 ppm, such as, for example, approximately 180 ppm at approximately 40 ppm, still more than approximately 160 ppm at approximately 20 ppm, such as, for example, approximately 160 at approximately 40 ppm, still more than approximately 160 ppm at approximately 80 ppm, and still more than about 160 ppm to about 120 ppm, such as, for example, specifically about 120 ppm.
[0073] The amount of biocide is preferably reduced using a combination of one or more biocides eliciting a synergistic effect on one or more representative microorganisms such as, for example, E. coli, Staphilococcus aureus and Candida albicans. Detergent compositions
[0074] The detergent composition according to the present invention can preferably, in addition to one or more biocides, further comprise i) One or more surfactants; ii) One or more liquid vehicles; and iii) One or more chelating agents.
[0075] Furthermore, the detergent composition according to the present invention can preferably, in addition to one or more biocides, further comprise i) One or more surfactants; ii) One or more liquid vehicles; iii) One or more chelating agents; and iv) One or more detergent builders.
[0076] In one embodiment, the detergent compositions according to the invention comprise: one or more liquid vehicles in a total amount of approximately 60-95% (weight / weight); in one modality, one or more liquid vehicles are comprised in a total amount of approximately 70-90% (weight / weight); and in a preferred embodiment of the same one or more liquid vehicles are comprised in a total amount of approximately 75-85% (weight / weight); and one or more chelating agents in a total amount of approximately 1-5% (weight / weight); in one embodiment one or more chelating agents are comprised in a total amount of approximately 2-4% (weight / weight); in a preferred embodiment of the same one or more chelating agents are comprised in a total amount of approximately 3% (weight / weight); one or more surfactants in a total amount of approximately 200- 6000 ppm; in one embodiment, one or more surfactants are comprised of a total amount of approximately 300-3000 ppm; in one embodiment, one or more surfactants are comprised of a total amount of approximately 400-2000 ppm; in one embodiment one or more surfactants are comprised of a total amount of approximately 500-1500 ppm; in a preferred embodiment, one or more surfactants are comprised in a total amount of approximately 600-1400 ppm; and optionally, one or more biocides in a total amount of approximately 100-5000 ppm. In one embodiment, one or more biocides are comprised in a total amount of approximately 100-2500 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 100-1000 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 150-800 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 200-700 ppm; in one embodiment one or more biocides are comprised in a total amount of approximately 20-100 ppm; and in a preferred embodiment of the same one or more biocides are comprised in a total amount of approximately 250-600 ppm.
[0077] In a preferred embodiment of the biocidal detergent composition of the invention, one or more biocides meet the criterion that CMC (biocide)> MIC (biocide).
[0078] In another preferred embodiment of the biocidal detergent composition of the invention, the detergent composition meets the criterion that CMC (detergent)> MIC (biocide).
[0079] In the context of the present invention, MIC for yeast is the minimum inhibitory concentration at which a reduction of at least 103 is obtained. In a preferred embodiment, MIC for yeast is the minimum inhibitory concentration at which a reduction of at least 104 is obtained.
[0080] In the context of the present invention, MIC for bacteria is the minimum inhibitory concentration at which a reduction of at least 104 is obtained. In a preferred embodiment, MIC for bacteria is the minimum inhibitory concentration at which a reduction of at least 105 is obtained.
[0081] The present detergent compositions may comprise as an essential component at least one surfactant selected from the group consisting of anionic surfactants, zwitterionic surfactants, amphoteric surfactants, non-ionic surfactants, cationic surfactants as monovalent cationic surfactants, and mixtures thereof. By nature, any surfactant known in the detergent composition technique can be used as disclosed in (1) "Surfactant Science Series", Vol. 7, edited by WM Linfield, Marcel Dekker and in (2) "Surface - Active Agents & Detergents" , Volumes I and II, by Schwatz, Perry and Berch Appropriate levels of this component are in the range of 1.0% to 80%, preferably from 5.0% to 65%, more preferably from 10% to 50% by weight of the composition.
[0082] In one embodiment, the biocidal detergent composition of the invention comprises a surfactant: one or more biocides in a ratio of 2-12: 1-5 by weight. In another embodiment, the biocidal detergent composition comprises surfactant: one or more biocides in a ratio of 5-9: 2-4 by weight. In a preferred embodiment, the biocidal detergent composition comprises a surfactant; one or more biocides in a ratio of approximately 7: 3 (weight / weight).
[0083] A specific embodiment of the invention relates to a biocidal composition comprising water, propylene glycol, methyl glycinediacetic acid (for example, Trilon M) iso-C13 alcohol ethoxylate (for example, Lutensol TO 89), N, N- didecyl-N-methyl-poly (oxyethyl) ammonium propionate (eg Bardap 26) and poly- (hexamethylene-guanidium chloride) (eg Akacid Forte).
[0084] Another specific embodiment of the invention relates to a biocidal composition comprising water, propylene glycol, methyl glycinediacetic acid (for example, Trilon M), a mixture of fatty alcohols with 9 moles of ethylene oxide and fatty alcohols with 3 moles of ethylene oxide (eg Marlipal® 24/939), N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (eg, Bardap 26) and poly- (hexamethylene-guanidium chloride) ) (e.g. Akacid Forte).
[0085] In one embodiment of the invention, the bio-acid detergent composition according to the invention has a CMC of at least 0.5 mmol / l. in another embodiment, the CMC is at least 1 mmol / 1. In another embodiment, the CMC is at least 1.5 mmol / l. in yet another modality, the CMC is at least 2 mmol / l. in yet another modality, the CMC is at least 2.5 mmol / l. in yet another modality of the same, the CMC is at least 3 mmol / l. In one embodiment of the invention, the biocidal detergent composition according to the invention has a CMC of at least 0.02 g / l. in another modality, the CMC is at least 0.03 g / l. in yet another modality, the CMC is at least 0.05 g / l. in yet another modality, the CMC is at least 0.1 g / l. in yet another modality, the CMC is at least 0.15 g / l. Surfactants
[0086] A surfactant according to the invention is preferably a nonionic or monovalent cationic surfactant and is preferably of the general formula I: R (OCH2CH2) xOH
[0087] Where 1) R is C7-20 alkyl whereby alkyl is 7-20 carbon atoms, R can be optionally substituted with one or more substituents selected from the group consisting of alkyl, C3-8-cycloalkyl, C3 -8-cycloalkyl-Cl-6-alkyl, Cl-6-alkyl- C3-8-cycloalkyl, aryl-Cl-6-alkyl, aryl, Cl-6-alkyl-aryl, aryl-Cl-6-alkyl, Cl -6-alkyl-oxy, C3-8-cycloalkyl-oxy, C3-8-cycloalkyl-Cl-6-alkyl-oxy, C3-8-cycloalkyl-oxy-Cl-6-alkyl, Cl-6-alkyl-oxy -C3-8-cycloalkyl, Cl-6-alkyl-C3-8-cycloalkyl-oxy. aryl-Cl-6-alkyl-oxy and aryl, or R can be optionally substituted with one or two groups selected from Ra (OCH2CH2) yOH and Rb (OCH2CH2) zOH;
[0088] In which a. Each of Ra and Rb are independently C7-20-alkyl so the alkyl is 7-20 carbon atoms; B. Each of y and z is 2-12, so the polyethylene glycol comprises 2-12 repetitions of OCH2CH2; and 11) and x is 2-12 so that polyethylene glycol comprises 2-12 repetitions of OCH2CH2.
[0089] Provided that when R is C18-alkyl then the surfactant cannot comprise an alkoxylated fraction that comprises higher alkoxides than ethylene oxides.
[0090] In the context of the present invention, the term 'C7-20-alkyl' refers to a branched or unbranched C7-20-alkanyl, C7-20-alkenyl or C7-20-alkynyl group where: 'C7 -20-alkanyl 'refers to an alkanyl group that is 7-20 carbon atoms in length; - 'C7-20-alkenyl' means alkenyl groups that are 7-20 carbon atoms in length, the group including one or more double bonds and - 'C7-20-alkynyl' designates an alkynyl group that has 7-20 carbon atoms in length, the group including one or more triple bonds.
[0091] Similarly, the term 'C1-6-alkyl' refers to branched or unbranched C1-6-alkanyl, C2-6-alkenyl or C2-6-alkynyl where: - C1-6-alkanyl refers to an alkanyl group that is 1-6 carbon atoms in length; - 'C2-6-alkenyl' means an alkenyl group that is 2-6 carbon atoms in length; the group including one or more double bonds, and - 'C2-6-alkynyl' means an alkynyl group that is 2-6 carbon atoms in length, the group including one or more triple bonds.
[0092] The term 'C3-8-cycloalkyl' refers to a group of C3-8-cycloalkyl or a C3-8-cycloalkenyl in which: - 'C3-8-cycloalkyl' designates a monocyclic or bicyclic carbocycle having three to eight C-atoms, including but not limited to cyclopropyl, cyclopentyl, cyclohexyl, etc .; and - 'C3-8-cycloalkenyl' means a monocyclic or bicyclic carbocycle having three to eight C-atoms and a double bond, including but not limited to cyclopropenyl, cyclopentenyl, cyclohexenyl, etc.
[0093] The term 'aryl' refers to a carbocyclic aromatic group, such as phenyl or naphthyl.
[0094] The term 'C1-6-alkyl-oxy' refers to groups of the formula C1-6-alkyl-O- where C1-6-alkyl is as defined above.
[0095] The term 'C3-8-cycloalkyl-oxy' refers to groups of the formula C3-8-cycloalkyl-O- where C3-8-cycloalkyl is as defined above.
[0096] Under the terms C3-8-cycloalkyl-Cl-6-alkyl, Cl-6-alkyl-C3-8-cycloalkyl, aryl-Cl-6-alkyl, Cl-6-alkyl-aryl, aryl-Cl-6 -alkyl, Cl-6-alkyl-oxy, C3-8-cycloalkyl-oxy, C3-8-cycloalkyl-Cl-6-alkyl-oxy, C3-8-cycloalkyl-oxy-Cl-6-alkyl, Cl-6 - alkyl-oxy-C3-8-cycloalkyl, Cl-6-alkyl-C3-8-cycloalkyl-oxy. aryl-Cl-6-alkyl-oxy and aryl the terms C1-6-alkyl, C3-8-cycloalkyl, aryl, C1-6-alkyl-oxy and C3-8-cycloalkyl-oxy are as defined above.
[0097] Surfactants of the general formula (I) can be prepared using conventional methods known to the person skilled in the art.
[0098] In an embodiment of the general formula I, x is 4-8 so that the fraction of polyethylene glycol comprised in the surfactant on average has 4-8 repetitions of OCH2CH2.
[0099] In a preferred embodiment of the general formula I, x is 3-12 so that the fraction of polyethylene glycol comprised in the surfactant on average has 3-12 repetitions of OCH2CH2.
[00100] In another preferred embodiment of formula I, x is 8.
[00101] In another preferred embodiment of formula I, x is selected from 3 and 9 and mixtures thereof.
[00102] In an embodiment of formula I, R is C10-18-alkyl.
[00103] In an embodiment of formula I, R is C12-14-alkyl. In an embodiment of formula I, R is C12-alkyl. In an embodiment of formula I, R is C13-alkyl. In an embodiment of formula I, R is C14-alkyl.
[00104] In another embodiment of formula I, at least 80% by weight of R is C12-alkyl, C13-alkyl or C14-alkyl or mixtures thereof. In an embodiment of formula I, R is C10-18-alkyl.
[00105] In another embodiment of formula I, at least 90% by weight of R is C12-alkyl, C13-alkyl or C14-alkyl or mixtures thereof. In an embodiment of formula I, 60-80% by weight, as 65-75% by weight of R is C12-alkyl. In another embodiment of formula I, 15-35% by weight, as 20-30% by weight of R is C14-alkyl. In a specific embodiment of formula I, 60-80% by weight, as 65-75% by weight of R is C12-alkyl. 15-35% by weight, as 20-30% by weight of R is C14-alkyl.
[00106] In an embodiment of formula I, not more than 5% by weight, such as less than 2% by weight and preferably less than 1% by weight of R is C10-alkyl.
[00107] In an embodiment of formula I, not more than 5% by weight, such as less than 2% by weight, less than 1% and preferably less than 0.5% by weight of R is C17-18 -alkyl.
[00108] In an embodiment of formula I, not more than 5% by weight, such as less than 2% by weight, less than 1% and preferably less than 0.5% by weight of R is C18-alkyl .
[00109] In a modality R is essentially not C18-alkyl.
[00110] In an embodiment of formula (I), R is substituted with one or more substituents selected from the group consisting of Cl-6-alkyl (en / in) yl, C3-8-cycloalkyl (en) yl, C3- 8-cycloalkyl (en) yl-Cl-6-alkyl (en / in) yl, Cl-6-alkyl (en / in) yl-C3-8-cycloalkyl (en) yl, aryl- Cl-6-alkyl ( en / in) yl, aryl, Cl-6-alkyl (en / in) yl-aryl, aryl- Cl-6-alkyl (en / in) yl, Cl-6-alkyl (en / in) yl-oxy, C3- 8-cycloalkyl (en) yl-oxy, C3-8-cycloalkyl (en) yl-Cl-6-alkyl (en / in) yl-oxy, C3-8-cycloalkyl (en) yl-oxy-Cl- 6- alkyl (en / in) yl, Cl-6-alkyl (en / in) yl-oxy-C3-8-cycloalkyl (en) yl, Cl-6-alkyl (en / in) il-C3-8- cycloalkyl (en) yloxy. aryl-Cl-6-alkyl (en / in) yl-oxy and aryl-oxy-Cl-6-alkyl (en / in) yl and aryl.
[00111] In another embodiment of formula (I), R is substituted with one or two groups selected from Ra (OCH2CH2) yOH and Rb (OCH2CH2) zOH.
[00112] In yet another modality of formula (I), R is not substituted.
[00113] In one embodiment of the invention, the molar weight of a surfactant according to the invention is in the range of 100-1500 g / mol. In one embodiment, the molar weight of a surfactant is in the range of 200-1000 g / mol. In one embodiment, the molar weight of a surfactant is in the range of 300-800 g / mol. In a preferred embodiment, the molar weight of a surfactant is in the range of 400-700 g / mol.
[00114] In one embodiment of the present invention one or more surfactants is selected from the group consisting of zwitterionic surfactants, amphoteric surfactants, nonionic surfactants, cationic surfactants as monovalent cationic surfactants, and mixtures thereof. In one embodiment of the present invention one or more surfactants is selected from the group consisting of amphoteric surfactants, and non-ionic surfactants and mixtures thereof.
[00115] In one embodiment of the present invention, one or more surfactants are selected from the group consisting of Marlipal® 24/939, Daclor 70-1-23, Stepanol WA-extra E, Lutensol TO 89, and combinations thereof . See additional details below.
[00116] In one embodiment of the present invention, one or more surfactants are selected from the group consisting of Marlipal® 24/939, Daclor 70-1-23, Stepanol WA-extra E, Lutensol TO 89, Ampholac 7TX, and combinations thereof.
[00117] In a specific embodiment of the present invention two of one or more surfactants are Marlipal® 24/939 and Ampholac 7TX.
[00118] In a more preferred embodiment, one or more surfactants comprised in a biocidal composition containing the inventive surfactant are selected from the group consisting of nonionic surfactants as alkoxylated nonionic surfactants. Liquid vehicles
[00119] In a preferred embodiment of the present invention, one or more liquid vehicles are selected from the group consisting of water, ethanol, glycerol, glycerin, propylene glycol and combinations thereof. See additional details below. Chelating agents
[00120] In one embodiment of the present invention, one or more chelating agents are selected from the group consisting of Masquol P320 Na, methyl glycinediacetic acid (e.g., Trilon M), potassium tripolyphosphate, and combinations thereof. In a more preferred embodiment, one or more chelating agents is methyl glycinediacetic acid (for example, Trilon M), for example, as the trisodium salt or other acceptable toxicological salts or solvates thereof. See additional details below. Detergent builder
[00121] In one embodiment of the present invention, one or more detergent builders are selected from the group consisting of Mackadet® 40K, soft soap, sodium citrate, and combinations thereof. In a more preferred embodiment of the detergent according to the invention, the detergent does not comprise a detergent builder as defined herein. See additional details below. Anionic surfactants
[00122] The compositions of the invention may comprise an anionic surfactant. The compositions of the present invention may comprise a sulfonic acid surfactant, such as, for example, a sodium salt of alcohol ether sulphate, for example, sodium salt of ethylene ether glycol alcohol C12-13 (Daclor ® 70-1-23 AL), or a linear benzene sulfonic acid or water-soluble salt forms thereof. Anionic surfactant (s) are typically present at a level of 1.0% to 70%. Preferably from 5.0% to 50% by weight, and more preferably from 10% to 30% by weight of the composition.
[00123] Sulfonic acid or anionic sulfonate surfactants suitable for use here include the salt and acid forms of C5-20, more preferably C10-16, more preferably C11-13 alkylbenzene sulfonates, C5-20 alkyl ester sulfonates, alkane sulfonates primary or secondary C6-22, polycarboxylic acids of C5-20 sulfonate and any mixtures thereof, but preferably C11-13 alkyl benzene sulfonates.
[00124] Suitable anionic acid or sulfate salt surfactants for use in the compositions of the invention include primary and secondary alkyl sulfates having a linear or branched alkyl or alkenyl fraction having 9 to 22 carbon atoms, preferably 10 to 18 atoms carbon, and more preferably 12 to 18 carbon atoms. in one embodiment of the composition according to the present invention one of the anionic surfactants is sodium lauryl sulfate (such as, for example, Stepanol® WA-Extra).
[00125] Also available are beta-branched alkyl sulfate surfactants or mixtures of commercial materials available, having an average branching weight (of the surfactant or mixture) of at least 50%. Medium chain branched alkyl sulphonates or sulfates are also suitable anionic surfactants for use in the compositions of the invention. C5-22 are preferred, preferably C10-20 medium chain branched primary sulfates. When mixtures are used, an appropriate average total number of carbon atoms for the alkyl fractions is preferably in the range greater than 14.5 to 17.5. Preferred mono-methyl branched primary alkyl sulfates are selected from the group consisting of 3-methyl to 13-methyl pentadecanol sulfates, the corresponding hexadecanol sulfates and mixtures thereof. Derivatives of dimethyl or other biodegradable alkyl sulfates having light branching can be used similarly.
[00126] Other anionic surfactants suitable for use here include fatty methyl ester sulfonates and / or alkyl ethoxy sulfates (AES) and / or polyalkoxylated alkyl carboxylates (AEC). Mixtures of anionic surfactants can be used, for example, mixtures of alkylbenzenesulfonates and AES.
[00127] Anionic surfactants are typically present in the form of their salts with alkanol amines or alkali metals such as sodium and potassium. Preferably, the anionic surfactants are neutralized with alkanol amines such as Mono ethanol amine or triethanol amine, and are fully soluble in the liquid matrix of the compositions of the present invention. Amphoteric and zwitterionic surfactants
[00128] Amphoteric or zwitterionic detersive surfactants suitable for use in the composition of the present invention include those that are known for use in hair care or other cleaning means for personal care. Non-limiting examples of appropriate zwitterionic or amphoteric surfactants are described in US patents nos. 5,104,646 (Bolich Jr. And others), 5,106,609 (Bolich Jr. And others).
[00129] Amphoteric detersive surfactants suitable for use in the composition are well known in the art, and include those surfactants widely described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight or branched and in which one of the substitutes aliphatics contains 8 to 18 carbon atoms and one contains an anionic group such as carboxy, sulfonate, sulfate, phosphate or phosphonate. Amphoteric detersive surfactants suitable for use in the present invention include cocoanfoacetate, cocoanodacidate, lauroanfoacetate, lauroanphodiacetate and mixtures thereof.
[00130] Detersive zwitterionic surfactants suitable for use in compositions are well known in the art, and include those surfactants widely described as derivatives of aliphatic ammonium, phosphonium, and quaternary sulfonium compounds, in which the aliphatic radicals may be straight or radical mified, and in which one of the aliphatic substituents contains 8 to 18 carbon atoms and one contains an anionic group, such as carboxy, sulfonate, sulfate, phosphate or phosphonate. Zwitterionics such as betaines are suitable for use in the present invention.
[00131] Furthermore, amine oxide surfactants having the formula: R (EO) x (PO) y (BO) zN (O) (CH2R ') 2 ^ qH2O (I) are also suitable for incorporation in the compositions of the present invention. R is a relatively long chain hydrocarbyl fraction that can be saturated or unsaturated, linear or branched, and can contain 8 to 20, preferably 10 to 16 carbon atoms, and is more preferably C12-16 primary alkyl. R 'is a short chain fraction preferably selected from hydrogen, methyl and -CH2OH. When x + y + z is different from O, EO is ethyleneoxy, PO is propylenoneoxy and BO is butyleneoxy. Amine oxide surfactants are illustrated by C12-14 alkyldimethyl amine oxide.
[00132] Non-limiting examples of other anionic, zwitterionic, amphoteric or additional optional surfactants suitable for use in the compositions are described in McCutcheon's, Emulsifiers and Detergents, 1989 Annual, published by M. C. Publishing Co., and in US patents. 3,929,678, 2,658,072; 2,438,091; 2,528,378. a preferred amphoteric surfactant is Ampholac 7TX ™ also known as sodium talgamphopylcarboxyglycinate. Nonionic surfactants
[00133] In one embodiment of the present invention, the surfactant of formula I is a non-ionic surfactant.
[00134] The present compositions can also comprise, and preferably comprise, this type of detersive surfactant. Essentially any alkoxylated nonionic surfactant, suitably ones containing only carbon, hydrogen and oxygen can be included in the present compositions, although functional starch and other heteroatomic functional types can in general also be used. Mixed ethoxylated, propoxylated, butoxylated or alkoxylated surfactants are preferred, for example, non-ionic aromatic hydrocarbyl chains or ethoxylated / propoxylated aliphatics. Appropriate hydrocarbyl fractions can contain 6 to 22 carbon atoms and can be linear, branched, cycloaliphatic or aromatic and the nonionic surfactant can be derived from a primary or secondary alcohol.
[00135] Preferred alkoxylated surfactants can be selected from the classes of non-ionic condensates of lightly branched or linear ethoxylated / propoxylated or propoxylated / ethoxylated monohydric alcohols, which can be natural or synthetic.
[00136] In a preferred embodiment, one or more nonionic surfactants are selected from the group consisting of a mixture of C12-14 polyethylene glycol ether as a mixture of fatty alcohols with 9 moles of ethylene oxide and alcohols fatty with 3 moles of ethylene oxide (for example, Marlipal® 24/939); and iso-C12-14 alcohol ethoxylates such as iso-C13 alcohol ethoxylate (e.g., Lutensol TO 89) and combinations thereof. In a preferred embodiment of the invention the composition comprises nonionic ethoxylate as a linear alcohol ethoxylate, such as, for example, a mixture of polyethylene glycol ether of alcohol C12-14 (for example, CAS-NR 68439-50-9 comprised in Marlipal 24/939 ™ being a mixture of fatty alcohols with 9 moles of ethylene oxide and fatty alcohols with 3 moles of ethylene oxide) and combinations thereof. The average molar weight of CAS-NR 68439-50-9 comprised in Marlipal 24/939 ™ is approximately 447 g / mol.
[00137] In another preferred embodiment of the invention the composition comprises the non-ionic ethoxylate which is selected from the group consisting of iso-alcohol ethoxylates such as iso-C12-14 alcohol ethoxylates as preferably C13-iso alcohol ethoxylate (e.g. For example, CAS No. 69011-36-5 included in Lutensol® TO) of the formula: RO (CH2CH2O) xH, where R = iso-C13H27 and x = 2, 3, 5, 6, 6.5, 7, 8, 10, 11, 12, 15, 20; and combinations thereof. More preferably, Lutensol® TO 89, which has x = 8. The molar weight of CAS no. 69011-36-5 comprised in Lutensol® TO 89 is approximately 600 g / mol.
[00138] When R is C18-alkyl, then the surfactant may not comprise an alkoxylated moiety comprising higher alkoxides than ethylene oxides, such as Plurafac® LF 300 comprising CAS no. 69227-21-0, which is a low foaming non-ionic surfactant. Plurafac® LF 300 is a C1218 alcohol that is propoxylated ethoxylate. Therefore, Plurafac® is not within the scope of formula I above.
[00139] Alkylated alkyl phenyls such as nonyl phenyl ethoxylates can also be used appropriately.
[00140] A preferred nonionic surfactant is Marlipal 24/939 ™. Another preferred nonionic surfactant is Lutensol TO 89.
[00141] Especially suitable as a nonionic surfactant or co-surfactant are the condensation products of primary aliphatic alcohols with 1 to 75 moles of C2-3 alkylene oxide, more appropriately 1 to 15 moles, preferably 1 to 11 moles. Alcohol condensation products having an alkyl group containing 8 to 20 carbon atoms with 2 to 9 moles and in particular 3 or 5 moles of ethylene oxide per mole of alcohol are particularly preferred.
[00142] Suitable nonionic surfactants containing nitrogen as the heteroatom include the polyhydroxy fatty amides having the structural formula R'CONRZ, where R1 is a C5-31 hydrocarbyl, preferably straight chain C7-9 alkyl or alkenyl, more preferably alkyl or alkenyl C11-17 straight chain, or mixture thereof; R2 is H, C1-18, preferably C1-4 hydrocarbyl, 2-hydroxyethyl, 2-hydroxy propyl, ethoxy, propoxy, or a mixture thereof, preferably C1-4 alkyl, more preferably methyl; and Z is polyhydroxy hydrocarbyl having a linear hydrocarbyl chain with at least 3 hydroxyls directly connected to the chain. Z will preferably be derived from a reducing sugar such as glucose, a corresponding preferred compound being an N-methyl C 1-17 alkyl glucamide.
[00143] Other useful nonionic surfactants useful here include so-called "covered" nonionics in which one or more -OH fractions are replaced by - OR, where R is typically lower alkyl such as C1-3 alkyl; long-chain alkyl polysaccharides, more particularly the polyglycoside and / or oligosaccharide type, as well as nonionic surfactants derivable by esterifying fatty acids. Detersive surfactants containing cationic nitrogen
[00144] Detersive surfactants containing cationic nitrogen suitable for use in the compositions of the present invention have at least one quaternized nitrogen and a long-chain hydrocarbyl group. Compounds comprising two, three or even four long-chain hydrocarbyl groups are also included. Examples of such cationic surfactants include alkyl methyl methyl ammonium salts or their hydroxy alkyl substituted analogs, preferably compounds having the formula R1R2R3R4N + X-. R1, R2, R3 and R4 are independently selected from C1-26 alkyl, alkenyl, hydroxy alkyl, benzyl, alkyl benzyl alkenyl benzyl, benzyl alkyl, benzyl alkenyl and X is an anion. The hydrocarbyl groups R1, R2, R3 and R4 can be independently alkoxylated, preferably ethoxylated or propoxylated, more preferably ethoxylated with groups of the general formula (C2H4O) xH where x has a value from 1 to 15, preferably from 2 to 5. No more than one of R2, R3 or R4 must be benzyl. The hydrocarbyl groups R1, R2, R3 and R4 can independently comprise one or more, preferably two, ester - ([- 0- C (O) -]; [-C (O) -O-]) and / or a starch group ([0-N (R) -]; [-N (R) -O-]), where R is defined as R1 above. Anion X can be selected from halide, methyl sulfate, acetate and phosphate, preferably halide and methyl sulfate, more preferably chloride and bromide. The hydrocarbyl chains R1, R2, R3 and R4 can be fully saturated or unsaturated with a variable iodine value, preferably with an iodine value from 0 to 140. At least 50% of each alkyl or long chain alkenyl group is predominantly linear, but also branched and / or cyclic groups are included.
[00145] For cationic surfactants comprising only a long hydrocarbyl chain, the preferred alkyl chain length for R1 is C12-15 and preferred groups for R2, R3 and R4 are methyl and hydroxy ethyl.
[00146] In a preferred embodiment, the cationic surfactants according to the invention are monovalent.
[00147] For cationic surfactants comprising two or three or even four long hydrocarbyl chains, the preferred average chain length is C18, although mixtures of chain lengths having non-zero proportions of lower chains, for example, C12, C14, C16 and higher ones, for example, C20 may be quite desirable.
Preferred ester-containing surfactants have the general formula {(R5) 2N ((CH2) nER6) 2} + X-, wherein each R5 group is independently selected from C1-4 alkyl, hydroxy alkyl or C2-4 alkenyl; and wherein each R6 is independently selected from C8-28 alkyl or alkenyl groups; E is a fraction of ester, that is, -OC (O) - or -C (O) O-, n is an integer from 0 to 5, and X is an appropriate anion, for example, chloride, methosulfate and mixtures of the same.
[00149] A second type of cationic surfactant containing preferred ester can be represented by the formula: {(R5) 3N (CH2) nCH (O (O) CR6) CH2O (O) CR6} + X-, where R5, R6, X and n are defined as above. This class mentioned last can be exemplified by 1,2-bis [hardened tallowoyloxy] -3-trimethyl ammonium propane chloride.
[00150] Cationic surfactants suitable for use in the compositions of the present invention can be water-soluble, water-dispersible or water-insoluble. Liquid vehicles
[00151] The compositions of the present invention can optionally comprise one or more liquid carriers. The liquid carrier can be aqueous or non-aqueous; and can include water individually or individually organic solvents and / or mixtures thereof. Preferred organic solvents include monohydric alcohols, dihydric alcohols, polyhydric alcohols, glycerol, glycols, glycerin, polyalkylene glycols, such as polyethylene glycol and mixtures thereof.
[00152] In a more preferred embodiment of the present invention, one or more liquid vehicles are selected from the group consisting of water, ethanol, glycerol, propylene glycol, glycerin and combinations thereof. In a more specific embodiment, one or more liquid vehicles are propylene glycol and water and mixtures thereof.
[00153] Suitable monohydric alcohols include especially C1-4 alcohols, such as ethanol, propanol, isopropanol and butanol. 1,2-propanediol is preferred. Highly preferred on the organic solvent side are mixtures of solvents, especially mixtures of lower aliphatic alcohols such as ethanol, propanol, butanol, iso-propanol, and / or diols such as 1,2-propanediol or 1,3-propanediol. The liquid carrier is typically present in levels in the range of 1% to 95%, preferably 5% to 70%, more preferably 10% to 70%, even more preferably 20% to 70%, even more preferably 30% to 70% , and more preferably 40% to 70% by weight of the composition.
[00154] A preferred combination of liquid vehicles comprises water, ethanol and glycerol; for example in a ratio of approximately 16: 1: 3. Another liquid carrier system comprises water and glycerin; for example, in a ratio of approximately 65: 1, such as 60: 1, 50: 1, 40: 1, 30: 1 or 20: 1. Alternatively, a preferred liquid vehicle is water.
[00155] A more preferred combination of liquid vehicles comprises water and propylene glycol. In one embodiment of the invention, water and propylene glycol are comprised in a ratio of 10-18: 0.5: 1.5 by weight. In one embodiment of the invention, water and propylene glycol are comprised in a ratio of 12-16: 0.8: 1.2 by weight. In a preferred embodiment, water and propylene glycol are comprised in a ratio of approximately 14: 1 by weight. Detergent builder
[00156] The compositions of the present invention can optionally comprise a builder, at levels of 0.0% to 80% by weight, such as, for example 1%, 5%, 10%, or 20%, preferably from 3% to 70 % by weight, more preferably from 4% to 60% by weight of the composition. Preferably, the detergent according to the invention does not comprise a detergent builder.
[00157] In general, any known detergent builder is useful here, including inorganic types like zeolites, layered silicates, fatty acids and phosphates like alkali metal polyphosphates, and organic types including especially alkali metal salts (for example, sodium citrate), 2,2-oxisuccinate, carboxy methyloxy succinate, nitrilotriacetate or the di- or trisodium salt thereof and the like. Phosphate-free organic water-soluble builders that have relatively low molecular weight, for example, below 1,000, are highly preferred for use here. Other suitable builders include sodium carbonate and sodium silicates having varying ratios of SiO2: Na2O content, for example, 1: 1 to 3: 1 with the 2: 1 ratio being typical.
In particular, linear and / or branched saturated and / or unsaturated fatty acids, such as medium chain fatty acids (C6-12) or long chain fatty acids (C12-18) and preferably mixtures thereof, are particularly preferred. fatty acids. In some cases of the present invention it is particularly preferred to use C12-18 saturated and / or unsaturated, linear and / or branched fatty acids, and preferably mixtures of such fatty acids. Alternatively or in combination, it may be preferred to use C8-12 saturated and / or unsaturated, linear and / or branched fatty acids, and preferably mixtures of such fatty acids, such as, for example, coconut fatty acids and salts thereof. Mixtures of saturated and unsaturated fatty acids have been found to be highly preferred, for example, a mixture of fatty acid derived from rapeseed and whole cut fat covered acids C16-18, or a mixture of fatty acid derived from seed is preferred. rapeseed and a fatty acid derived from tallow alcohol, coconut fatty acids, alkyl succinic fatty acids, oleic, palmitic, soybean oil fatty acids, and mixtures thereof. Preferably potassium cocoate (Mackadet® 40-K) and / or soft soap. Also preferred are branched fatty acids of synthetic or natural origin, especially branched biodegradable types.
[00159] Mixtures of any of these fatty acid builders can be advantageous to further promote solubility. It is known that fatty acids of lower chain length promote solubility but this needs to be balanced with the knowledge that they are frequently of bad odor, for example, in chain lengths of C9 and below.
[00160] Although the term “fatty acid builder” is in common use, it must be understood and recognized that as formulated in the present detergents, the fatty acid can be in at least partially neutralized to neutralized form, counterions can typically be alkanol amines, sodium, potassium, ammonium alkanol or mixtures thereof. Preferably, the fatty acids are neutralized with alkanol amines such as Mono ethanol amine, and are completely soluble in the liquid phase.
[00161] Fatty acids can be builders in the compositions of the present invention. It was found that the presence of fatty acid builders contributes to the formation of a coacervate. The presence of fatty acid builders in the compositions of the present invention is therefore preferred. Foam suppressor
[00162] The compositions of the present invention can optionally comprise and preferably comprise a foam suppressant. Foam suppressors suitable for use here may comprise essentially any known anti-foam compound or mixture, typically at a level of less than 10%, preferably 0.001% to 10%, more preferably 0.01% to 8%, more preferably 0, 05% to 5%, by weight of the composition. Suitable foam suppressors may include low solubility components such as highly crystalline waxes and / or hydrogenated fatty acids, silicones, silica / silica mixtures, or more sophisticated composite foam suppressor combinations, for example, those commercially available from companies such as Dow Corning . Compound silicones are suitably used at levels of 0.005% to 0.5% by weight. More soluble defoaming agents include, for example, 2-lower alkyl alkanols such as 2-methyl-butanol. Stabilizer
[00163] The compositions of the present invention can optionally comprise and preferably comprise a stabilizer. Appropriate levels of that component are in the range of 0.0% to 20%, preferably 0.1% to 10% and even more preferably 0.1% to 3% by weight of the composition. The stabilizer serves to stabilize certain components of the compositions of the present invention by preventing them from coagulating and / or forming cream.
[00164] Stabilizers suitable for use here can be selected from thickening stabilizers. These include gums and other similar polysaccharides, for example, gellan gum, carrageenan gum, and other known types of thickeners and rheological additives other than highly polyanionic types; thus conventional clays are not included.
[00165] More preferably the stabilizer is a stabilizing agent containing hydroxyl, crystalline and / or hydrogenated jojoba, more preferably still, a trihydroxy stearin, hydrogenated oil or a derivative thereof. Chelating agent
[00166] The compositions of the present invention can optionally comprise and preferably comprise a chelating agent. Chelating agents suitable for use here include P-free, nitrogen-containing aminocarboxylates, such as EDDS, EDTA and DTPA; aminophosphonates, such as diethylenetriamine pentamethylenophosphonic acid and ethylenediamine tetramethylenophosphonic acid; nitrogen-free phosphonates, for example, HEDP; and P-free carboxylate chelating agents, containing nitrogen or oxygen, as compounds of the general class of certain macrocyclic N-ligands, such as those known for use in bleach catalyst systems. Levels of chelating agents are typically lower than 6%, such as, for example, approximately 4-5%, or at levels of 0.01% to 3%. In a preferred embodiment of the invention, the chelating agent is selected from the group consisting of sodium salt of aminotri (methylene phosphonic acid) penta (Masquol P320 Na ™), methylglycinediacetic acid, trisodium salt (for example, Tri-lon® M) , and potassium tripolyphosphate. Most preferably selected from the group consisting of aminotri sodium (methylene phosphonic acid) penta (Masquol P320 Na ™) and methylglycinediacetic acid, trisodium salt (for example, Trilon® M). in a more preferred embodiment, one or more chelating agents is methylglycinediacetic acid (for example, Trilon M), for example, as the trisodium salt or other acceptable toxicological salts or solvates thereof. Other constituents
[00167] The washing detergent according to the present invention can optionally further comprise foam stabilizers (for example, amine oxides, for example, cocoamine-N-oxide), anti-irritating agents, sequestering agent, bleaches, fragrances , dyes, dye transfer inhibitors, pH adjusting agents (eg, sodium citrate or triethanol amine), opacifiers, antioxidants, preservatives (eg, integra® 44) or combinations thereof.
[00168] For the purposes and intent of the present invention, the compositions of the present invention can typically have a pH ranging from pH 5.5 to pH 14, with, for example, pH 5.5 to pH 7, pH 6 to pH 7 , preferably between pH 6.0 and pH 11, more preferably between pH 6 and pH 8. Alternatively, the pH can be in the range between pH 7.5 and pH 11. In a preferred embodiment of the invention the pH is approximately pH neutral , approximately pH 7.
[00169] The washing detergent according to the present invention may optionally further comprise water-soluble polymers, such as polymeric dispersing agents. Non-limiting examples of these are, for example, copolymers of acrylic acid and sulfonated monomers, for example, Alcosperse®240, to provide deposit control; or polymers of carboxylated and non-carboxylated monomers, for example, Alcosperse 747, to provide detergent improvement.
[00170] The washing detergent according to the present invention can optionally further comprise fabric care ingredients, which are not fabric cleaning ingredients. In general, any fabric care ingredient known in the detergent composition technique can be used. However, certain fabric care ingredients are preferred, such as fabric care ingredients selected from the group consisting of clays, silicon-free amine compounds, silicon-free quaternary ammonium compounds, nitrogen-free silicone polymers, polymers amino silicone, anionic silicone polymers, cationic silicone polymers, polyolefins, and mixtures thereof. In a preferred embodiment of the present invention where the delicate laundry detergent is to be used especially for washing textile articles containing wool, it is preferred that the composition comprises lanolin as a wool care additive. Lanolin can be, for example, Lanolin PEG 75/5 LV, and it can preferably be present in an amount of approximately 0.5% to 5.0% by weight, such as 2.0%. In a preferred embodiment of the present invention where the delicate washing detergent is to be used especially for washing silk-containing textile articles, it is preferred that the composition comprises an agent for maintaining silk textile articles, such as, for example, cosmacol® ESI, and may preferably be present in an amount of approximately 0.1% to 5.0% by weight, for example, approximately 0.1% to 3%, 0.2% to 2%, 0.3% to 1% , preferably approximately 0.5% by weight. When included in the compositions of the invention, appropriate concentrations of fabric care ingredients are generally 0.01% to 30%, preferably 0.1% to 10% and more preferably 0.5% to 5.0% by weight of the composition.
[00171] The laundry detergent composition according to the present invention may optionally further comprise a cationic deposit auxiliary medium, such as a modified cationic deposit auxiliary medium. This is especially preferred when the compositions comprise one or more fabric care ingredients. The deposit aid is to increase the deposit rate and extent, for example, of an optional tissue care ingredient present. Typical levels of a deposit aid, if present, are in the range of 0.001% to 10%, preferably 0.05% to 5.0%, more preferably 0.1% to 2.5% by weight of the composition. Preparation
[00172] The liquid washing detergent compositions of the present invention can be prepared in any appropriate manner and can, in general, involve any order of mixing or adding the composition components, unless otherwise mentioned.
[00173] All patent and non-patent references cited in the application, or in this application, are hereby incorporated by reference in their entirety. Items
[00174] A specific aspect of the invention relates to items 1-28 below: 1. Washing detergent composition comprising one or more bicarbonates. 2. Composition, according to item 1, where the composition is a delicate laundry detergent composition. 3. Composition according to either item 1 or 2, where the composition is a liquid washing detergent. 4. Composition, according to any of the previous items, in which one or more biocides are selected from the group consisting of PQ polymers; a polymer of biguanide polymer; an alkyl oxyethylene methyl ammonium salt; dialkyl oxyethylene methyl ammonium salt; povidone-iodine; an alkyl dimethyl benzyl ammonium salt; dialkyl methyl benzyl ammonium salt; a dialkyl dimethyl ammonium salt; and a bispiridine; or acceptable toxicological salts or solvates thereof. 5. Composition, according to any of the previous items, in which one or more biocides is a polymer of polymeric biguanide, or acceptable toxicological salts or solvates thereof. 6. Composition according to item 5, in which the biocide is selected from the group consisting of PHMB, poly (hexamethylene biguanide) hydrochloride, akacid forte®, and Akacid®, or other acceptable toxicological salts or solvates thereof. 7. Composition according to any of the previous items, in which one of one or more biocides is an alkyl or dialkyl oxyethylene methyl ammonium salt. 8. Composition according to item 7, in which the biocide is selected from the group consisting of N, N-didecyl-N-methyl-poly (oxyethyl) ammonium propionate (Bardap 26) and N, N-didecyl-N -methyl-poly (oxyethyl) ammonium lactate. 9. Composition, according to any of the previous items, in which one of one or more biocides is povidone-iodine. 10. Composition according to any of the preceding items, wherein one of one or more biocides is an alkyl dimethyl benzyl ammonium salt or a dialkyl methyl benzyl ammonium salt. 11. Composition according to item 10, in which the biocide is selected from the group consisting of benzyl dimethyl ammonium chloride predominantly with C12-14 alkyl; benzyl methyl ammonium dicoco chlorides predominantly with C12-14 alkyl; benzyl chlorides C12-18alkyl dimethyl ammonium; benzyl chlorides C12-14- alkyl dimethyl ammonium and C12-13-alkyl [(ethyl phenyl) methyl] dimethyl ammonium chlorides (ADBAC). 12. Composition, according to item 10, in which the biocide is C12-13-alkyl [(ethyl phenyl0 methyl] dimethyl ammonium chloride (ADBAC). 13. Composition according to any of the previous items, in which one of one or more biocides is a dialkyl dimethyl ammonium salt 14. Composition, according to item 13, in which the biocide is selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, and chloride octyl dimethyl ammonium (DDAC) 15. Composition, according to any of the previous items, in which one of one or more biocides is a bispiridine, or accepted toxicological salts or solvents thereof. 16. Composition, according to item 15, in which the biocide is octenidine dihydrochloride 17. Composition according to any of the previous items, in which one of one or more biocides is a PQ polymer, or acceptable toxicological salts or solvates thereof. , according to item 17, in which the biocide is polymer of N, N-dimethyl-2-hyd chloride roxi propyl ammonium. 19. Composition according to any one of items 1-4, in which one or more biocides is a mixture of Akacid Forte® and Bardap-26. 20. Composition, according to any of the previous items, in which the composition does not comprise enzymes. 21. Composition according to any of the previous items, in which the composition is suitable for washing at low temperatures in a range of 5 ° C to 40 ° C. 22. Composition according to any of the previous items, in which the delicate washing detergent also comprises: i) One or more surfactants; ii) One or more liquid vehicles; iii) One or more chelating agents; and iv) One or more detergent builders. 23. Composition, according to item 22, in which one or more surfactants are selected from the group consisting of zwitterionic surfactants, amphoteric surfactants, non-ionic surfactants, cationic surfactants and mixtures thereof. 24. Composition, according to any of items 22 or 23, in which one or more surfactants is selected from the group consisting of Marlipal® 24/939, Daclor 70-1-23, Stepanol WA-extra E, Lutensol TO 89 , Plurafac LF 300, Ampholac 7TX and combinations thereof. 25. Composition according to any of items 22-24, in which one or more liquid vehicles is selected from the group consisting of water, ethanol, glycerol, glycerin and combinations thereof. 26. Composition, according to any of items 22-25, in which one or more chelating agents are selected from the group consisting of Masquol P320 Na, Trilon M, potassium tripolyphosphate and combinations thereof. 27. Composition, according to any of items 22-26, in which one or more detergent builder is selected from the group consisting of Mackadet® 40K, soft soap, sodium citrate, and combinations thereof. 28. Composition, according to any of the previous items, where the composition is for washing clothes or textile articles considered to be a source of infection, for example, washing hospital clothes or washing clothes for the nursing home. Figures
[00175] Figures 1 and 2 show the CMD absorption data obtained for diluted Detergent A (table 8a) Figures 3 and 4 show the CMC absorption data obtained for diluted Detergent B (table 8c) Figures 5 and 6 display the CMC absorption data obtained for diluted Akacid Forte. EXAMPLES
[00176] The following non-limiting examples are illustrative of the present invention. The percentages are by weight unless otherwise specified. Example 1
[00177] Delicate washing liquid detergent for wool and fine textile articles
[00178] The table below provides a detergent composition to be combined with one or more biocides as described here. This specific detergent composition is preferably for washing wool, and can be used for other fine textile articles.

Example 2
[00179] Liquid detergent for washing delicate clothes for silk and fine textile articles
[00180] The table below provides a detergent composition to be combined with one or more biocides as described here. This specific detergent composition is preferably for washing silk, and can be used for other fine textile articles.
Example 3 Washing of clothes, liquid, for textile articles
[00181] The table below provides a detergent composition to be combined with one or more biocides as described here. This specific detergent composition is for washing textile articles in general, and can be used for fine textile articles.
Example 4 Test for biocidal effect
[00182] One or more biocides are tested for biocidal effect in vitro. One biocide can be tested alone or two or more biocides in combination. Five different concentrations of one or more biocides can be tested, for example, at two different temperatures in the range of 20-40 ° C. the exposure time of biocide to microorganism can be selected to represent the desired washing process for the laundry detergent composition in question. For example, 1 hour for a delicate washing detergent suitable for washing wool or silk, or 2 hours for a washing detergent suitable for washing heavy loads, for example, hospital textiles.
[00183] One or more biocides can be tested against the following microorganisms: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginoosa, and Candida albicans. Escherichia coli was chosen to represent a gram negative fecal bacterium; Staphylococcus aureus was chosen to represent a gram-positive, heat-tolerant bacterium; Pseudomonas aeruginosa was chosen to represent a bacterium that causes diseases that in some cases are difficult to treat; and Candida albicans represent the presence of fungi.
[00184] The reduction in different microorganisms is quantified. This test can be used to determine the biocidal effect of a specific biocide, or a combination of biocides. The latter determining whether a synergistic effect is obtained. Example 4A Biocidal effect - dosing response
[00185] The test is based on the requirements for chemical disinfectants and antiseptic agent with respect to a reduction in fungus and bacteria of 4 and 5 log units respectively. These requirements are mentioned in DS / EN 1276: 1997 and DS / EN 1275: 2005, respectively. Microorganisms and material cultures
[00186] The following microorganisms were chosen for this dosage response assay: Staphylococcus aureus, ATCC 6538, representing gram positive bacteria; Escherichia coli, ATCC 11229, representing gram negative bacteria; and
[00187] Candida albicans, ATCC 2091, representing yeast fungi.
[00188] Bacterial cultures were grown in the TSB (Tryptic Soy Bouillon) growth medium for 24 h at 37 ° C before use. Colony forming units (CFU) were determined by coating triptych soy agar (TSA).
[00189] Candida albicans was grown on malt extract agar (MEA) for 24 h at 37 ° C before use. Then, the yeast cells were harvested in 0.9% saline using a drigalski spatula. CFU were determined by coating on MEA.
[00190] The cultures described above are called material cultures. Biocides
[00191] The tested biocides and concentrations can be seen in table 1. Table 1: test concentrations of biocides
* Akacid Plus is a mixture of Akacid and Akacid Forte in a 1: 1 ratio. Biocide exposure
[00192] Exposure to biocide was carried out at pH 6-6.5 which was obtained by adding 100 mM of potassium phosphate buffer. To test tubes with 8mL of sterile 100 mM phosphate buffer, 1 ml of test solution (ie, biocidal solution) and 1 ml of material culture were added. After complete mixing, the test mixtures were exposed to heating in a water bath at 30 ° C for 9 minutes. after exposure the test tubes were immediately removed from the water bath and the surviving microorganisms were determined by coating.
[00193] Reference samples were prepared by adding 1 ml of sterile water instead of 1 ml of test solution. Agar Coating
[00194] From the appropriate dilutions of starting material (mixture of biocidal solution, culture of material and buffer) 0.1 ml was taken on Agar plates, and the material was spread with Drigalski spatulas. The plates were incubated at 37 ° C 1 day for bacteria and 2 days for yeast.
[00195] To determine CFU of the bacterium after exposure, with and its biocide, incubation in TSA for 24 h at 37 ° C was used. to determine CFU of Candida albicans before and after exposure, it was used incubated in MEA for 48 h at 37 ° C.
[00196] Where a large reduction in organisms was expected (test concentrations of 700 and 200 ppm) 1 ml and 0.1 ml of solution, respectively, were mixed with 100 ml of sterile water and filtered through a 47 µm membrane filter mm Millipore EZ-Pak®, mesh 0.22 um. The filter was rinsed with 100 mL of sterile water, and then placed directly on the agar plate. Mixing with water and subsequent rinsing ensures that the biocide is heavily diluted and will therefore have no effect after coating. For dilutions of 100 x and more, regular coating was used, since the biocide at these concentrations is considered to provide no further reduction in microorganisms during coating on Agar.
[00197] Plates with between 20 and 500 CFU were chosen for counting. The number of CFU (colony forming units) per g or mL of sample was calculated by multiplying the number of colonies per plate with the dilution and additionally by 10, since only 0.1 mL was used in each plate.
[00198] After incubation, CFU was determined and reduction in organisms was calculated. All tests were performed in triplicate. Results of
[00199] Regarding E. coli, see table 2, especially Bardap-26 and Akacid Forte showed a good effect. The count provided a reduction in organisms from> 107 to Bardap at a concentration of 160 ppm. The effect was less for Akacid Forte where the reduction in organisms was only> 105. The remaining biocides showed no or limited effect.
[00200] Barquat PC-2 showed no effect, and can be used as a negative control. These findings show the importance of choosing the appropriate biocide for the intended microorganism. Table 2: reduction obtained in E. coli

* Akacid Plus is a mixture of Akacid and Akacid Forte in a 1: 1 ratio. ** the test solutions were prepared in aqueous solutions at a concentration corresponding to 10 times the desired (PPM = mg per kg / liter)
[00201] Regarding Staphylococcus Aureus, see table 3, especially Bardap-26 at 160 ppm and in part Akacid Forte showed a good effect, while the remaining biocides did not show or showed very limited effect. Bardap-26 reduced Staphylococcus Aureus by> 107 by 160 ppm. Akacid Forte reduced by> 104. Barquat PQ-2 showed no effect, and can be used as a negative control. These findings again show the importance of choosing the appropriate biocide for the intended microorganism. Table 3: reduction obtained in Staphilococcus Aureus

* Akacid Plus is a mixture of Akacid and Akacid Forte in a 1: 1 ratio. ** the test solutions were prepared in aqueous solutions at a concentration corresponding to 10 times the desired (PPM = mg per kg / liter)
[00202] Regarding Candida Albicans, see table 4, especially Bardap-26 showed a good effect, while the remaining biocides did not show or showed very limited effect. Bardap-26 reduced Candida albicans by 104. Barquat PQ-2 showed no effect, and can be used as a negative control. These findings again show the importance of choosing the appropriate biocide for the intended microorganism. Table 4: reduction obtained in Candida albicans
Example 4B Biocidal effect - synergistic effect
[00203] The optimal biocides, Bardap-26 and Akacid Forte, found in example 4A, were additionally tested for synergistic effect. Bardap-26 and Akacid Forte were mixed in a 50:50 ratio, and the applied concentrations can be seen from table 5. The methods and solutions were otherwise as described in example 4A of the present invention. Table 5: Test concentrations of 50:50 mixtures of Bardap-26 and Strong Acid
Results of
[00204] As can be seen from table 6, a clear and surprising synergistic effect was found for all tested organisms. The synergistic effect was especially evident for E. coli, since a total elimination was found. For Staphylococcus Aureus and Candida albicans a synergistic effect was similarly found, since the combination provided a significant increase in reduction compared to the effects previously observed for biocide alone. Table 6: Reductions obtained in three organisms by using a 50:50 mixture of Bardap-26 and Akacid Forte

Gray indicates high effect. Example 5 Test for washing and biocidal effect
[00205] Microorganisms, as mentioned in example 4, are inoculated into the textile article in question. For a delicate laundry detergent the textile article is wool and / or silk, and for a heavy-duty detergent composition the textile article can be cotton, a textile article containing cotton, a textile article containing polyester, etc.
[00206] The inoculated textile article is washed by standard methods with the washing detergent to be tested. Washing is carried out at different temperatures, concentrations, and under conditions suitable for the intended use of the laundry detergent composition.
[00207] The reduction in different microorganisms is quantified.
[00208] This test is used to determine the biocidal effect of washing detergent under washing conditions. Example 6
[00209] Washing detergent, liquid, for fine textile articles
[00210] The table below provides a liquid washing detergent composition for fine textile articles, that is, a liquid washing detergent, to be combined with one or more biocides as described here; preferably Bardap-26 or Akacid Forte, or a mixture thereof. Table 7: test concentrations of biocides

[00211] Liquid laundry washing can be prepared by adding the components in the specified amount of water and shaking after adding each component. Thereafter, the pH is adjusted to pH 6.0 - 6.5. Example 7 Liquid washing detergent for fine textile articles
[00212] The liquid washing detergents, exemplified, for fine textile articles, ie delicate washing detergents, comprise:. one or more chelating agents such as, but not limited to, Trilon M,. one or more non-ionic surfactants or monovalent cationic surfactants such as, but not limited to, the surfactants selected from the group consisting of Lutensol TO 89 and Marlipal 24/93. one or more liquid vehicles with, but not limited to, water and propylene glycol. optionally one or more biocides such as, but not limited to, biocides selected from the group consisting of Bardap-26 and Akacid Forte
[00213] The detergents A, B and C below were prepared with and without biocides (tables 8a-f): Table 8a: detergent A with biocides

Table 8b: detergent A without biocides
Table 8c: detergent B with biocides
Table 8D: detergent B with biocides

Table 8e: Detergent C with biocides
Table 8f: Detergent C without biocides
* a content of 5% (weight / weight) Bardap-26 comprising 70% CAS 94667- 33-1 in each of the detergents A, B and C provides a content of 3.5% (weight / weight) CAS 94667-33- 1, which is the active ingredient in Bardap-26. ** a content of 5% (weight / weight) Akacid Forte comprising 25% CAS 57028-96-3 in each of the detergents A, B and C provides a content of 1.25% (weight / weight) CAS 57028-96- 3, which is the active ingredient in Akacid Forte.
[00214] Liquid washing detergents A, B and C with and without biocides can be prepared by adding the components to the specified amount of water and stirring after adding each component. Thereafter, the pH is adjusted to pH 6-7 using, for example, lactic acid.
[00215] The stability of liquid washing detergents A, B and C comprising 5% (weight / weight) Bardap-26 and 5% (weight / weight) Akacid Forte was analyzed after 1 week of storage at -18 ° C, 5 °, 20 ° C and 58 ° C. Table 9

[00216] Detergent C without biocides is the only detergent of detergents A without biocides, B without biocides and C without biocides that was not stable. Conclusion
[00217] No precipitate occurred in detergent A with biocides after storage for 1 week at -18 ° C - 58 ° C. no precipitate occurred in composition B with biocides after storage for 1 week at -18 ° C - 58 ° C. no precipitate occurred in composition C, with biocides after storage for 1 week at -18 ° C - 58 ° C. as a conclusion, liquid washing detergents A, B and C are stable. Detergent C without biocides is not stable. Example 8 Biocidal effect of detergent and detergent with biocides Cultures of yeast material and bacteria
[00218] Staphylococcus aureus, ATCC 6538 representing Gram positive bacteria. Escherichia coli, ATCC 11229 representing gram-negative bacteria. Candida albicans, ATCC 2091 representing yeasts.
[00219] Bacteria were grown in TSB (Tryptic Soy Bouillon) at 37 ° C for 24 hours. This culture was called a bacterial material culture.
[00220] Candida albicans was grown in MEA (Malt extract agar) at 37 ° C for 24 hours. The yeast was harvested by adding 10 mL of 0.9% NaCl per plate and the yeast was loosened with a Drigalski spatula. The yeast suspension was collected in a jar with glass beads and rotated to ensure an even distribution of the cells. This culture was called the yeast material culture. The yeast CFU counts after exposure were performed using normal MEA plate counts at 37 ° C for 48 hours. Biocidal material solution
[00221] A 12000 ppm biocidal material solution comprising 6000 ppm of the active ingredient in Akacid Forte (CAS 57028-96-3) + 6000 ppm of the active ingredient in Bardap-26 (CAS 94667-33-1) was made in buffer of potassium phosphate, pH 6.0. Test solution 1
[00222] Test solution 1 was prepared by adding 0.5 ml of solution of biocide material and 8.5 ml of potassium phosphate buffer in sterile test tubes. Test solution 1 does not contain detergent. Test solution 2
[00223] Test solution 2 was prepared by adding 1.0 ml of solution of biocide material and 8 ml of potassium phosphate buffer in sterile test tubes. Test solution 2 does not contain detergent.
[00224] Before use in test solutions 3-8, detergent solutions A and B with and without biocides were made according to example 7 and pH was adjusted to 6.0 - 6.5 by adding 1M NaOH. Test solution 3
[00225] Detergent A without biocides (table 8b) was diluted with water to a concentration of 5.4 g / liter of test solution: detergent A comprises 11.25% (weight / weight) of the active ingredient in Luensol TO 89 (CAS No. 69011-36-5). Thus, test solution 3 comprises CS no. 69011-36-5 in an amount of 0.61 g / liter of test solution.
[00226] Test solution 3 does not comprise biocide. Test solution 4
[00227] Detergent A with biocides (table 8a) was diluted with water to a concentration of 6 g / 900 ml of test solution: detergent A comprises 11.25% (weight / weight) of the active ingredient in Lu- tensol TO 89 (CAS No. 69011-36-5). Thus, test solution 4 comprises CS no. 69011-36-5 in an amount of 0.675g / 900 ml of test solution. detergent A comprises 3.5% (weight / weight) of the active ingredient in Bardap-26 (CAS NR 94667-33-1). Thus, test solution 4 comprises CAS 94667-33-1 in an amount of 0.21 g / 900 ml of test solution. detergent A comprises 1.25% (weight / weight) of the active ingredient in Acacid Forte (CAS NR 57028-96-3). Thus test solution 4 comprises CAS 57028-96-3 in an amount of 0.075 g / 900 mol of test solution. In total, test solution 4 comprises biocides in the amount of (0.21 + 0.075) g / 900 ml = 0.285 g of biocides / 900 ml of test solution. Test solution 5
[00228] Detergent A with biocides (table 8a) has been diluted with water to a concentration of 12 g / 900 ml of test solution: Detergent A comprises 11.25% (weight / weight) of the active ingredient in Luensol TO 89 (CAS No. 69011-36-5). Thus, test solution 5 comprises CS no. 69011-36-5 in an amount of 1.35 g / 900 ml of test solution. detergent A comprises 3.5% (weight / weight) of the active ingredient in Bardap-26 (CAS NR 94667-33-1). Thus, test solution 4 comprises CAS 94667-33-1 in an amount of 0.42 g / 900 ml of test solution. detergent A comprises 1.25% (weight / weight) of the active ingredient in Acacid Forte (CAS NR 57028-96-3). Thus, test solution 4 comprises CAS 57028-96-3 in an amount of 0.15 g / 900 mol of test solution.
[00229] In total, test solution 5 comprises biocides in the amount of (0.42 + 0.15) g / 900 ml = 0.57 g of biocides / 900 ml of test solution. Test solution 6
[00230] Detergent B without biocides (Table 8d) was diluted with water to a concentration of 5.4 g / liter of test solution: Detergent B comprises 11.25% (weight / weight) of the active ingredient in Marlipal 24 / 939 (CAS-NR 68439-50-9). Thus test solution 6 comprises CAS-NR 68439-50-9 in an amount of 0.61 g / liter of test solution.
[00231] The test solution does not comprise biocide. Test solution 7
[00232] Detergent B with biocides (table 8c) was diluted with water to a concentration of 6 g / 900 ml of test solution: Detergent B comprises 11.25% (weight / weight) of the active ingredient in Marlipal 24 / 939 (CAS No. 68439-50-9). Thus, test solution 7 comprises CS no. 68439-50-9 in an amount of 0.675g / 900 ml of test solution. detergent B comprises 3.5% (weight / weight) of the active ingredient in Bardap-26 (CAS NR 94667-33-1). Thus, test solution 4 comprises CAS 94667-33-1 in an amount of 0.21 g / 900 ml of test solution. detergent B comprises 1.25% (weight / weight) of the active ingredient in Acacid Forte (CAS NR 57028-96-3). Thus test solution 4 comprises CAS 57028-96-3 in an amount of 0.075 g / 900 mol of test solution.
[00233] In total, test solution 7 comprises biocides in the amount of (0.21 + 0.075) g / 900 ml = 0.285 g of biocides / 900 ml of test solution. Test solution 8
[00234] Detergent B with biocides (Table 8c) was diluted with water to a concentration of 12 g / 900 ml of test solution: Detergent B comprises 11.25% (weight / weight) of the active ingredient in Marlipal 24 / 939 (CAS No. 68439-50-9). Thus, test solution 8 comprises CS no. 68439-50-9 in an amount of 1.35 g / 900 ml of test solution. detergent B comprises 3.5% (weight / weight) of the active ingredient in Bardap-26 (CAS NR 94667-33-1). Thus, test solution 4 comprises CAS 94667-33-1 in an amount of 0.42 g / 900 ml of test solution. detergent B comprises 1.25% (weight / weight) of the active ingredient in Acacid Forte (CAS NR 57028-96-3). Thus, test solution 4 comprises CAS 57028-96-3 in an amount of 0.15 g / 900 mol of test solution.
[00235] In total, test solution 8 comprises biocides in the amount of (0.42 + 0.15) g / 900 ml = 0.57 g of biocides / 900 ml of test solution. Experimental
[00236] 9 ml of test solution 1, 2, 3, 4, 5, 6, 7 or 8 were added to a sterile test tube. 1 ml of culture of bacterial material or culture of yeast material was added immediately before exposure.
[00237] Thus, the concentration during exposure was as follows: Table 10: exposure concentrations


[00238] Test solutions were exposed to microorganisms for 9 minutes at 30 ° C.
[00239] The number of surviving bacteria was determined immediately after exposure. The bacterial CFU (colony-forming units) after exposure to batteries was performed using normal plate counts on TSA (triptych soy agar) plates at 37 ° C for 24 hours. The yeast CFU counts after exposure were performed using normal plate counts in MEA at 37 ° C for 48 hours.
[00240] All tests were performed in triplicate. Results and conclusion Table 11: Exposure results

[00241] By incorporating detergent C comprising Plurafac LF 300 (prepared according to example 7) in a test solution comprising Bardap-26 and Akacid Forte, then reductions as low as 102 yeast are obtained.
[00242] The results show that (table 11): a reduction of 105 yeast was obtained at the lowest concentration of biocide present in test solutions 4 and 7. a reduction of 106 of yeast was obtained at the highest concentration of biocide present in test solutions 4 and 7. a reduction of 107 in yeast was obtained in the concentration of biocide in test solutions 5 and 8. the same reduction was obtained for all test solutions when exposed to Staph. Aureus and E. coli. the same results were obtained for Lutensol TO 89 and Marlipal 24/939. there is no difference in the reduction of bacteria obtained for test solutions 1 and 2 compared to test solutions 4, 5, 6 and 7. there is no difference in the reduction of yeast obtained for test solutions 1 and 2 compared to solutions of test 5 and 8. the addition of Lutensol TO 89 and Marlipal 24/939 had no significant impact on the biocide effect of the biocides. no reduction of the tested organism was seen when exposed to test solutions 3 and 6. the addition of Plurafac LF300 in detergent C leads to a reduction in yeast as low as a factor 100.
[00243] A reduction as high as 105 yeast was obtained after exposure to biocidal detergent compositions in which the biocide concentration was as low as 285 ppm. Therefore, in a non-limiting example, exposure under the same conditions to biocide compositions where the concentration of biocide was as high as 600 or 1200 ppm without detergent only increased the yeast reduction with a factor of 10 for a reduction of yeast 106.
[00244] In one embodiment, the same yeast reduction was obtained by exposing it to a biocidal composition without detergent and by exposing it to a biocidal detergent composition. Therefore, in a non-limiting example, the same reduction of 106 yeast was obtained after exposure to biocidal detergent compositions comprising 570 ppm biocide and 600 or 1200 ppm biocidal composition without detergent.
[00245] In one embodiment, at least the same antibacterial effect was obtained by exposing it to a biocidal composition without detergent and by exposing it to a biocidal detergent composition. Therefore, in a non-limiting example, the same reduction of 107 bacteria was obtained after exposure to biocidal detergent compositions comprising 285 or 570 ppm biocide and 600 or 1200 ppm biocidal composition without detergent. The same reduction was obtained regardless of the bacteria tested.
[00246] Conclusion
[00247] Based on the above results, it is concluded that the addition of Lu- tensol TO 89 and Marlipal 24/939 does not have a significant impact on the biocidal effect of Marlipal 24/939 and Bardap-26. Example 9 Test solutions
[00248] Detergent A with biocides and detergent B with biocides obtained from example 7 tables 8a + c were tested. In addition a solution comprising Water 75% (weight / weight); and Akacid Forte 25% (weight / weight) Experimentally tested
[00249] The concentration of critical micelle is measured using Sudan Black B dissolved in the test solutions in different concentrations. Sudan Black B is dissolvable in micelles, only. A difference in the measured absorbance is thus a valid measure of the critical micelle concentration in the test solutions.
[00250] Sudan Black has the structure below.

[00251] Absorbance was measured using a Shi- madzu UV-1800 spectrophotometer and absorbance is measured at 600 nm.
[00252] The dilutions were made in water and Sudan Black B by first adding water, then Sudan Black B and lastly the test solutions in 4 ml cuvettes. The dilutions were then stirred and left for at least 6 hours at room temperature. Then, the absorbance was measured. CMC results for detergent A (table 8a) CMC for diluted detergent A (table 8a) was measured at 0.097 g / l (figures 1 and 2) detergent A (table 8a) comprises 11.25% (weight / weight) of active ingredient in Lutensol TO 89 (CAS No. 69011-36-5). Thus, the diluted detergent A comprises CAS no. 69011-36-5 in an amount of 10.9 mg / l of solution. CMC for detergent B (table 8c) CMC for diluted detergent B (table 8c) was measured at 0.03 g / l (figures 3 and 4) detergent B (table 8a) comprises 11.25% (weight / weight) of the active ingredient in Marlipal 24/939 (CAS No. 68439-50-9). Thus, the diluted detergent B comprises CAS no. 68439-50-9 in an amount of 3.38 mg / l of solution. CMC for Akacid Forte CMC for diluted Akacid Forte was measured at 15 g / l (figures 5 and 6) that 15 g / l dilution is diluted with a 25% (weight / weight) solution of Akacid Forte and thus comprises 3.75 g / l. Akacid Forte comprises the active ingredient CAS 57028-96-3 in an amount of 25% (weight / weight). Thus, the dilution of 15 g / l comprises CAS 57028-96-3 in an amount of 0.938 g / l. CMC for Bardap-26 is approximately 0.7 - 1.0 mmol / l (data not shown).

权利要求:
Claims (24)
[0001]
1. Composition CHARACTERIZED by the fact that it comprises a mixture of the poly (hexamethylene-guanidium chloride) and N, N-didecyl-N-methyl-poly (oxyethyl) -propionate biocides, said biocides having synergistic effect, in which said composition does not comprise a surfactant.
[0002]
2. Detergent composition CHARACTERIZED by the fact that a mixture of the biocides poly (hexamethylene-guanidium chloride) and N, N-didecyl- N-methyl-poly (oxyethyl) -ammonium propionate is purchased, said biocides having synergistic effect and one or more surfactants selected from the group consisting of nonionic surfactants and monovalent cationic surfactants, in which said one or more surfactants are of the general formula (I): R (OCH2CH2) xOH where i) R is C7 alkyl -20 whereby the alkyl is 7-20 carbon atoms, said R can be optionally substituted with one or more substituents selected from the group consisting of alkyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6 -alkyl, C1-6- alkyl-C3-8-cycloalkyl, aryl-C1-6-alkyl, C1-6-alkyl-aryl, aryl-C1-6-alkyl, C1-6-alkyl-oxy, C3-8 -cycloalkyl-oxy, C3-8-cycloalkyl-C1-6-alkyl-oxy, C3-8-cycloalkyl-oxy-C1-6-alkyl, C1-6-alkyl-oxy-C3-8-cycloalkyl, C1-6 -C3-8alkyl-cycloalkyl-oxy, aryl-C1-6- alkyl-oxy and air ila, or where R is optionally substituted with one or two groups selected from C7-20 alkyl- (OCH2CH2) yOH and C7-20-alkyl- (OCH2CH2) zOH; in which a. C7-20-alkyl means an alkyl of 7-20 carbon atoms; B. Each of y and z is 2-12, so the polyethylene glycol comprises 2-12 repetitions of OCH2CH2; and ii) x is 2-12 so that polyethylene glycol comprises 2-12 repetitions of OCH2CH2, with the proviso that when R is C18-alkyl then the surfactant cannot comprise an alkoxylated moiety that comprises higher alkoxides than oxides of ethylene.
[0003]
3. Composition, according to claim 2, CHARACTERIZED by the fact that it additionally comprises i) one or more liquid vehicles; and ii) one or more chelating agents.
[0004]
4. Composition according to any one of claims 2 and 3, CHARACTERIZED by the fact that x is 4-8 so that the polyethylene glycol comprised in the surfactant on average has 4-8 repetitions of OCH2CH2.
[0005]
Composition according to any one of claims 2 to 4, CHARACTERIZED by the fact that R is C12-14 alkyl.
[0006]
6. Composition according to any of claims 2 to 5, CHARACTERIZED by the fact that at least 80% by weight such as at least 90% by weight of R is C12-alkyl, C13-alkyl or C14-alkyl or mixtures of themselves.
[0007]
7. Composition according to any one of claims 2 to 6, CHARACTERIZED by the fact that it comprises a surfactant of formula (I) in which R is substituted with one or more substituents selected from the group consisting of C1-6-alkyl ( en / in) yl, C3-8-cycloalkyl (en) yl, C3-8-cycloalkyl (en) yl-C1-6-alkyl (en / in) yl, C1-6-alkyl (en / in) il- C3-8-cycloalkyl (en) yl, aryl-C1-6-alkyl (en / in) yl, C1-6-alkyl (en / in) yl-aryl, aryl-C1-6-alkyl (en / in) useful, C1-6-alkyl (en / in) yl-oxy, C3-8-cycloalkyl (en) yl-oxy, C3-8-cycloalkyl (en) yl-C1-6-alkyl (en / in) il- oxy, C3-8-cycloalkyl (en) yl-oxy-C1-6-alkyl (en / in) yl, C1-6-alkyl (en / in) yl-oxy-C3-8-cycloalkyl (en) yl, C1-6-alkyl (en / in) yl-C3-8-cycloalkyl (en) yl-oxy, aryl-C1-6-alkyl (en / in) yl-oxy and aryl-oxy-C1-6-alkyl ( en / in) il and arila.
[0008]
8. Composition according to any one of claims 2 to 6, CHARACTERIZED by the fact that it comprises a surfactant of formula (I) in which R is substituted with one or two groups selected from C7-20-alkyl- (OCH2CH2) yOH and C7-20-alkyl- (OCH2CH2) zOH.
[0009]
9. Composition according to any one of claims 2 to 6, CHARACTERIZED by the fact that it comprises a surfactant of formula (I) in which R is not substituted.
[0010]
10. Composition according to any one of claims 2 to 9, CHARACTERIZED by the fact that the one or more surfactants are selected from the group consisting of non-ionic surfactants such as alkoxylated non-ionic surfactants.
[0011]
11. Composition according to any one of claims 2 to 10, CHARACTERIZED by the fact that one or more surfactants are selected from the group consisting of a mixture of polyethylene glycol ether C12-14 such as a mixture of fatty alcohols with 9 mol of ethylene oxide and fatty alcohols with 3 mol of ethylene oxide and alcohol-iso-C12-14 ethoxylates such as alcohol-C13-iso ethoxylate and combinations thereof.
[0012]
12. Composition according to any one of claims 2 to 11, CHARACTERIZED by the fact that it comprises only a surfactant which is selected from the group consisting of a mixture of polyethylene glycol ether C12-14 alcohol such as a mixture of fatty alcohols with 9 mol of ethylene oxide and fatty alcohols with 3 mol of ethylene oxide.
[0013]
13. Composition according to any one of claims 1 to 11, CHARACTERIZED by the fact that it comprises only a surfactant which is selected from the group consisting of alcohol-iso-C12-14 ethoxylates such as alcohol-iso-C13-ethoxylate and combinations thereof.
[0014]
14. Composition according to any one of claims 2 to 13, CHARACTERIZED by the fact that CMC (biocide)> MIC (biocide).
[0015]
15. Composition according to any one of claims 2 to 14, CHARACTERIZED by the fact that CMC (detergent)> MIC (biocide).
[0016]
16. Composition according to any one of claims 1 to 15, CHARACTERIZED by the fact that it comprises one or more liquid vehicles selected from the group consisting of water, ethanol, glycerol, propylene glycol, glycerin and combinations thereof.
[0017]
17. Composition according to any one of claims 1 to 16, CHARACTERIZED by the fact that it comprises one or more liquid vehicles selected from propylene glycol and water and mixtures thereof.
[0018]
18. Composition according to any one of claims 1 to 17, CHARACTERIZED by the fact that it comprises one or more chelating agents selected from the group consisting of phosphonic amino-tri (methylene) acid, methylglycinediacetic acid (eg sodium nitrilotriacetate) ), potassium tripolyphosphate, and combinations thereof, such as methylglycinediacetic acid (for example, sodium nitrilotriacetate), for example, as the trisodium salt or other acceptable toxic salts or solvates thereof.
[0019]
19. Composition according to any one of claims 2 to 18, CHARACTERIZED by the fact that the composition is suitable for cleaning such as washing at low temperatures in the range of 5 ° C to 40 ° C.
[0020]
20. Composition according to any one of claims 2 to 19, CHARACTERIZED by the fact that the composition is a detergent composition for washing clothes, such as a detergent composition for washing delicate clothes.
[0021]
21. Composition according to any one of claims 2 to 20, CHARACTERIZED by the fact that the composition is for washing clothes or textile articles considered to be a source of infection, for example, washing hospital clothes or washing clothes nursing home.
[0022]
22. Composition according to any one of claims 2 to 21, CHARACTERIZED by the fact that the composition does not comprise enzymes.
[0023]
23. Composition according to any one of claims 2 to 22, CHARACTERIZED by the fact that it is a liquid washing detergent.
[0024]
24. Composition according to any one of claims 1 to 23, CHARACTERIZED by the fact that it is with or without a surfactant, which is for use, for example, in: disinfectants and biocidal products in general such as in biocidal human hygiene products ; disinfectants in the private and public health areas and other biocidal products; biocidal veterinary hygiene products; and feed and food disinfectants and drinking water disinfectants; condoms such as canned condoms; film condoms; wooden condoms; fiber, leather, rubber and polymerized condoms; masonry condoms; condoms for liquid processing and cooling systems, slimicides; and metallurgical fluid condoms; pest control such as rodenticides; avicides; molluscicides; pesticides; insecticides; acaricides and products to control other arthropods; and repellents and attraction agents; other biocidal products such as preservatives for food or inputs; anti-fouling products, embalming fluids and taxidermists; and control of other vertebrates; worms such as on or in domestic animals, livestock animals or pets; seaweed; and products for use, for example, in spas, swimming pools and the like.

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JP2001214197A|2001-08-07|Liquid detergent composition

同族专利:

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公开号 | 公开日

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CN102947435B|2017-06-06|

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US9719057B2|2017-08-01|

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SI2553073T1|2018-02-28|

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PT2553073T|2017-08-03|

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HRP20171105T1|2017-10-06|

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RS56349B1|2017-12-29|

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CN102947435A|2013-02-27|

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ES2634197T3|2017-09-27|

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WO2011116775A3|2012-03-08|

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US20160017262A1|2016-01-21|

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US20130177518A1|2013-07-11|

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BR112012024553A2|2016-05-31|

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CY1119426T1|2018-03-07|

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WO2011116775A2|2011-09-29|

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EP2553073A2|2013-02-06|

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LT2553073T|2017-08-10|

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HUE035303T2|2018-05-02|

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EP2553073B1|2017-05-03|

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DK2553073T3|2017-08-14|

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PL2553073T3|2017-09-29|

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法律状态:
2018-04-10| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|

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2019-02-26| B06T| Formal requirements before examination|

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2019-11-19| B07A| Technical examination (opinion): publication of technical examination (opinion)|

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2020-12-08| B09A| Decision: intention to grant|

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2021-03-02| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/03/2011, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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DKPA201070128|2010-03-26|

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DKPA201070128|2010-03-26|

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PCT/DK2011/050099|WO2011116775A2|2010-03-26|2011-03-25|Laundry detergent|

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