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    • 专利摘要:
    apparatus and method for ocular imaging, - the object of the present invention relates to ocular imaging by a mounted slit lamp, an integrated slit lamp, a laptop computer, oct integrated or connected to a mounting apparatus with a rest bar. split chin and method for producing a wide field of view and/or magnified views of the posterior or anterior segments of an eye through an undilated or dilated pupil. the images and focal planes of the device and use a lighting system that uses one or more LEDs, optical lighting elements, inversion masks and/or aperture closures where light is provided to the optical system in the optical axis or outside the axis of the center of the optical system and eye image return path, creating artifacts at different locations in the eye image. image processing is used to detect and eliminate artifacts and image masks. the apparatus can be used in combination with an oct, microscope and can be arranged in a portable housing for use.
    公开号:BR112012023716B1
    申请号:R112012023716-0
    申请日:2011-03-22
    公开日:2021-07-13
    发明作者:Steven Verdooner
    申请人:Neurovision Imaging Inc；
    IPC主号:
    专利说明:

    The present invention relates to an apparatus and method for ocular imaging and claims priority to U.S. Provisional Application 61/316677 filed 03/23/2010, the full description of which is incorporated herein by reference.
    Examining the eye is a challenge in relation to obtaining images that are of good quality, that include a wide field of view, that are free of central artifacts and other factors, that are in stereo, that can be obtained with ease. operator use, which can achieve proper alignment, focus, and exposure for both dilated and undilated pupils in the posterior and anterior segments of the eye.
    The present invention generally relates to a system and method for ocular imaging. The present invention provides a combination of innovative optical, mechanical, and image processing techniques which comprises using optical technologies combined with various image processing techniques to obtain artifact-free images. More specifically, the invention is a system and method for ocular imaging, which can be used in different modes of operation and configurations, which include a mounted, portable microscope, integrated with optical coherence tomography (OCT) devices, integrated with ophthalmoscopies direct and indirect, a slit lamp, an integrated slit lamp or coupled to a separate chin rest bar mounting configuration (background camera) included with a plurality of accessories. The invention is able to examine patients without optics and other optical artifacts and also achieve a wide field of view compared to current fundus cameras and other eye imaging devices.
    The present invention will be described by way of exemplary, but without limitation, forms illustrated in the accompanying drawings, in which, as references indicate similar elements, and in which:
    Figure 1A illustrates a side perspective view of an ocular imaging apparatus used in combination with a computer, in accordance with an embodiment of the present invention.
    Figure 1B illustrates a side perspective view of a camera housing, in accordance with an embodiment of the present invention.
    Figure 1C illustrates a front perspective view from above of an eyepiece, in accordance with one embodiment of the present invention.
    Figure 1D is an exploded diagram in diagonal lateral perspective of a computer system in accordance with one embodiment of the present invention.
    Figure 2 illustrates a side perspective view of an ocular imaging apparatus used in combination with a microscope, in accordance with an embodiment of the present invention.
    Figure 3 illustrates a side perspective view of an ocular imaging apparatus that is operated in accordance with an embodiment of the present invention.
    Figure 4A is a flowchart of a method for producing an image of an eye, in accordance with one embodiment of the present invention.
    Figure 4B illustrates a front perspective view of image capture of an eye and artifact points, in accordance with one embodiment of the present invention.
    Figure 4C illustrates a front perspective view of an inverted eye image capture mask, in accordance with one embodiment of the present invention.
    Figure 4D illustrates a front perspective view of composite eye image without artifact, in accordance with one embodiment of the present invention.
    Various aspects of illustrative embodiments will be described using terms commonly employed by those skilled in the art to convey the substance of their work to other persons skilled in the art. However, it will be apparent to those skilled in the art that the present invention can be practiced with only a few of the aspects described. For purposes of explanation, specific numbers, materials and configurations are presented in order to provide a full understanding of the illustrative embodiments. However, it will be apparent to one skilled in the art that the present invention can be practiced without the specific details. In other examples, well-known features are omitted or simplified so as not to obscure illustrative embodiments.
    Several operations will be described as multiple discrete operations, in turn, in a way that is more useful for understanding the present invention.
    However, the order of description should not be construed to imply that these operations are necessarily order-dependent. In particular, these operations do not need to be performed in the order of presentation.
    The phrase "in one embodiment" is used repeatedly. The phrase does not generally refer to the same embodiment, however it may refer. The terms "comprising", "having" and "including" are synonymous unless the context dictates otherwise.
    The apparatus for producing an image of an eye can be used for examining the eye and other medical applications, including but not limited to imaging the anterior segment of the eye, including but not limited to the cornea, lens, an anterior camera, a tear film, and also a posterior segment image, including background color, fluorescein angiography and ICG angiography imaging, as well as free red, blue, red, near infrared and infrared, spectral wavelengths of auto-fluorescence imaging and functional, such as flavoprotein autofluorescence, fluorophores in the retinoid cycle and others, curcumin fluorescence imaging, and other contrast agents used to examine eye diseases and also neurodegenerative diseases. The apparatus for producing an image of an eye can be used at high magnification or it can provide a very wide field of view and can be operated in a magnification mode. The apparatus for producing an image of an eye can be operated in a plenoptically mode allowing various focal lengths to be combined into a composite image which can be sectioned by, or combined into a single image.
    One embodiment of the apparatus for producing an image of an eye allows the use of a stereopsy mode for near real-time generation of stereo images. The apparatus for producing an image of an eye may contain an eyeball to create a patient interface and darkened environment for operation in a non-mydriatic mode. The eyeball can be used to hold a person's eyelids open.
    Another embodiment of the apparatus for producing an image of an eye can be used as a targeting treatment and/or a treatment planning system.
    The apparatus for producing an image of an eye is a low cost, portable and/or integrated slit lamp mounted and/or chin rest bar mounted device, and/or a suitable microscope mounted eye imaging device to view a wide field and/or enlarged views of retinal images through an undilated or dilated pupil.
    The apparatus for producing an image of an eye is also capable of examining the anterior segment of the eye as well as sections and focal planes arranged between the sections. Apparatus for producing an image of an eye includes an illumination system such as an LED, Halogen, Xenogen, or other suitable illumination system, aperture switches and reflection masks. The lighting system includes one or more light sources, preferably white LED light or light of an individual wavelength for specific tests, or tunable light sources, which can be conducted to the optical system, either along an optical axis, or slightly off-axis from the center of the optic system or eye and return the retinal imaging path.
    The apparatus for producing an image of an eye provides input of light rays into the eye for wide retinal field illumination, reduced glare and elimination of primary artifacts and reflections.
    Aperture switches, inverted masks, image processing and/or off-axis lighting eliminate unwanted reflections or glare formed in the retinal image. The apparatus for producing an image of an eye is well suited for viewing the retina through an undilated pupil, such as a pharmacologically undilated pupil or a dilated pupil as small as 1.5 mms., and establishes the apertures and masks are sized according to the diameter of an undilated pupil. The adjustment of this aperture 15 and/or masks can be fixed or can be adjusted by the user. It can also automatically detect pupil size and auto-optimize aperture and/or mask size, light source position, and masks. The apparatus for producing an image of an eye may use a reflection mask which momentarily blocks unwanted reflections while leaving other areas of the image illuminated. The artifact-free regions of sequential images can also be combined to form an artifact-free composite image.
    The apparatus for producing a continuous image or film of an eye may utilize a means of tracking the eye and adjusting to different views thereby moving artifacts to different geographic regions in the eye, and subsequently combining those images or parts of images into a final composite image. which is free artifact.
    Another embodiment of the apparatus for producing an image of an eye uses one, two or more light sources, with a lateral shift and/or rotation of optical elements to shift the illumination and/or field of view, combined with the eye mask. fast sequential inversion. These optical designs also illuminate and provide an image with a wider field of view over the retina than current cameras. In addition, when images are combined, a final image with more evenly distributed lighting, more accurate focus and aberration correction is created.
    The apparatus for producing an image of an eye contains an image processing algorithm that automatically detects any artifacts in the image and performs image reconstruction using valid image information from the corresponding images in which the artifact has been masking the retina in the image. of the source. The apparatus for producing an image of an eye may or may not use strobe lighting but does not combine several images and mixes the images together after performing removal of the similar artifact from one or more series of images, and/or changes in fixation of the eye. patient.
    The optical design can contain one or more light sources and can add a prism, such as a penta half prism, Schmidt prism or bespoke that redirects the illumination and image paths to be slightly offset from each other, creating the illumination and superimposed images for an increased field of view, and can also be used in combination with sequentially arranged inversion masks. These alternate illumination and image paths may enter the pupil at an angle to the optical center or may enter slightly off-axis but parallel to the center of the optical system. The angle of separation of these various superimposed light sources and image paths can be variable depending on pupil size. This 15 can automatically adjust based on automatic pupil size detection.
    Another embodiment of the apparatus for producing an image of an eye provides for tilting the optical components to specifically remove or position reflections and artifacts. The apparatus for producing an image of an eye contains a manual focus and/or an autofocus mechanism. The apparatus for producing an image of an eye has an automatic exposure and image brightness algorithm and contrasts the optimization algorithm to optimize image quality. The apparatus for producing an image of an eye may contain an image stabilization or eye tracking algorithm. The apparatus for producing an image of an eye has an alignment mode in either visible light, NIR, or IR that allows the user to align an image of the eye along an outer pupil and/or visible light and/or infrared image of the eye. retina. The apparatus for producing an image of an eye may contain a mechanical or automated alignment and control algorithm for aligning a pupil of the eye along an optical axis to the patient's pupil.
    The apparatus for producing an image of an eye may contain a spatial light modulator for positioning and shaping the illumination beam in accordance with the detected location and dimensions of the pupil, in combination with an inversion mask for artifact removal. The apparatus for producing an image of an eye can measure and record pupil size. The apparatus for producing an image of an eye can record the response to pupillary stimulus introduced into the optical train for perimetry testing purposes. The apparatus for producing an image of an eye may contain a dark adaptation test mode which introduces a flash to whiten the retina followed by internal stimuli of various wavelengths to determine the rod and/or cone response, especially in the screening for age-related macular degeneration or AMD and other disease states. The apparatus for producing an image of an eye may contain a way of performing optical coherence tomography in combination with the other imaging modalities. Apparatus for producing an image of an eye may employ an infrared or near-infrared light filter or a light source that is in place for alignment mode and pulled out to allow other spectral wavelengths to pass and subsequent image capture.
    One embodiment of the apparatus for producing an image of an eye uses an anti-shake optical eye tracker, and/or other image stabilization software algorithm to automatically align the apparatus to produce an image of an eye to the eye of the eye. patient, and also facilitates image alignment for standardization and other image processing and viewing functions.
    Another embodiment of apparatus for producing an image of an eye that hits optical artifact by traveling through an oscillating objective lens or other internal optical or masking element that achieves the production of an image located adjacent to the artifact produced by the oscillating objective lens. Real-time artifact remapping can be applied to this set of images for artifact elimination. This embodiment of the apparatus for producing an image of an eye provides for real-time creation of stereo pairs of images due to flickering and shifting. The oscillation can be of different frequencies to achieve a desired result. This can also be combined with eye tracking and patient fixation changes to create a wide retinal field of view generated from multiple images, films, or image parts, either in post-processing or in near real-time.
    Another embodiment of the apparatus for producing an image of an eye builds a comprehensive image across multiple planes of the eye by gradual focusing and introducing additional optical elements to achieve the shift in focus.
    Another embodiment of the apparatus for producing an image of an eye utilizes all of the modalities described above incorporated into a therapeutic planning and/or positioning system.
    Fast sequential inversion of an artifact mask and subsequent image reconstruction can be achieved with a variety of lighting strategies in addition to the described light source point. The mask can be implemented through the use of a mechanical inversion element, an opto-electronic closed window mechanism, or a synchronized rotation mask with an image capturing capability of one or more light sources. The area under the artifact would be temporarily exposed and captured, and subsequently combined with other areas of previously acquired images to create a composite image of free artifact. The mask can also serve as a patient fixation and/or eye alignment device or mechanism.
    The apparatus for producing an image of an eye may contain a wireless SD card or other built-in wireless device to automatically transmit images to a computer or other storage device or software. The device for producing an image of an eye can allow the user to take an image of the patient's name, apply optical character recognition technology, detect the patient's first name, last name and graphic code, record the date and time image and automatically store the information in a database and transmit the information to a wireless host. This can be done by a processor integrated in the apparatus to produce an image of an eye, or by a central computer.
    The apparatus for producing an image of an eye may also utilize a flexible eyeball, which can be attached to the apparatus to produce an image of an eye, or be used as a flexible, disposable eyeball that connects the end of the apparatus to produce a image of an eye for use on each patient. The eyeball can be made of a flexible deflector material such as plastic, rubber, or any other suitable material that gently wraps the patient's eye to create a dark environment and can also be used to hold a patient's eyelids open. The eyeball may have an internal angle spring mechanism (or compressible sponge-like material) that holds the patient's eyelids open. The deflectors are flexible to allow for adjustable and proper positioning around the patient's eye.
    One embodiment of the apparatus for producing an image of an eye contains a firm rubber or plastic portion of the eyeball that is located approximately along a vertical axis so that the eyeball is used to hold a patient's upper eyelid open during the exam. The rest of the eyeball is placed over the patient's eye to create a dark environment. This mode of operation creates a dark environment for the patient's natural pupil dilation. Another embodiment of the eye cup is only the uppermost parts used to keep the upper pupil open during the exam.
    Apparatus for producing an image of an eye may also include an infrared or near infrared LED light or other light source illumination system, coupled with a detector, such as a charge-coupled device or CCD, a metal oxide semiconductor. complementary or CMOS, or other suitable type of detector that is sensitive to light at a specific wavelength. The detector should be used for alignment, but it could also be turned off and the patient would be illuminated with visible light, green light, blue light, or free-red light wavelengths for examination including fluorescein angiography, ICG angiography, auto fluorescence background, hyper and multi-spectral imaging, curcumin fluorescence imaging or other wavelengths used in other fluorescence or functional examinations with a variety of contrast agents.
    Apparatus for producing an image of an eye can have all of the embodiments described above, in addition to creating a plenoptic multifocal image or other image or film that is created from images in multiple focal planes. This image is formed by a camera system that has micro-lenses on top of a CCD or CMOS pixel array that is divided into two or more focal planes. This image can be calibrated and reconstructed into a multi-focal plenoptic image. Alternatively, a multifocal plenoptic image can be created using a manual or autofocus mechanism that finds the ideal center focus and then acquires additional images with slight focus adjustments in brackets around the focal center point. These images can be combined into a single plenoptic image or can be combined into an interactive film image that allows the user to navigate through multiple focal planes. The algorithm for combining images automatically aligns the images by correcting for translation, rotation, curvature, and magnification differences between the images. The software can detect high frequency information in each image plane corresponding to an element. The plenopti algorithm can also be used to combine images from different modalities. For example, ICG images highlighting choroidal detail can be combined with fluorescein images highlighting retinal detail. The plenoptic algorithm can be used for any combination of retinal images. The plenooptic algorithm can also be applied to focal multi-plane images in the anterior segment of the eye. These modalities can also be combined with OCT datasets for sectioned retinal images that contain multiple planes and image parts.
    One embodiment allows for continuous capture of images or films through the entire eye from front to back and allows application of the plenoptic algorithm to form a single plenotic image or movie view function.
    Another embodiment of the apparatus for producing an image of an eye allows for rapid or simultaneous capture or rapid sequential capture of multiple image modalities and recombination into composite images as individual frames or pattern images.
    Another embodiment of the apparatus for producing an image of an eye can also be implemented in combination with a wavefront sensor for automatic positioning and correction of aberrations. The apparatus for producing an image of an eye can be combined with a deformable mirror and wavefront sensor for correction of both high and low order aberrations. The apparatus for producing an image of an eye and all embodiments thereof may include components, light sources and filters that allow all retinal types of retinal imaging, including, but not limited to, red background color image free, ICG angiography, fluorescein angiography, IR or near IR imaging, all forms of auto-background fluorescence at various wavelengths, hyper- and multi-spectral imaging, curcumin fluorescence imaging, and functional examination with a variety of agents of contrast.
    Another embodiment of the apparatus for producing an image of an eye uses slit lamp imaging parts and is rotated in front of a slit lamp slit lamp objective lens.
    Another embodiment of the apparatus for producing an image of an eye utilizes the slit lamp modification which also utilizes the existing slit lamp illumination system for anterior segment and retinal imaging.
    Another embodiment of the apparatus for producing an image of an eye would be portable use, integrated with a direct or indirect ophthalmoscope, or with the apparatus for producing an image of an eye connected to a microscope.
    Another embodiment of the apparatus for producing an image of an eye would be to combine the apparatus for producing an image of an eye with the optical coherence tomography or OCT test modality.
    Another embodiment of the apparatus for producing an image of an eye uses a mode where images are captured and move together in real time, real time film streams are analyzed for artifacts and optimal focus, and images they are reconstructed from "good" parts of images taken from the video stream.
    Another embodiment of the apparatus for producing an image of an eye allows the user to program the internal fixation target for the patient to follow and then fix the images together as they are captured. This would also apply to artifact removal. Multiple images can be stored as a movie file, single structure or a single structure pinned together. The internal fixture can be in a variety of forms, including an inversion "stick" that contains an LED array, which can be programmed by the user to a specific position. The internal inversion LED stick is automatically moved out of place during image capture.
    Another embodiment of the apparatus for producing an image of an eye introduces stimuli through an LCD light and a beam cutter or other suitable mechanism for microperimetry testing.
    Another embodiment of the apparatus for producing an image of an eye uses interchangeable objective lenses for different fields of view, and also for anterior segment imaging.
    Another embodiment of the apparatus for producing an image of an eye includes a lens, switches and a mask device that is optimized for back-illumination imaging of the eye's lens.
    Another embodiment of the apparatus for producing an image of an eye applies a dark correction algorithm in which an image from the CCD or CMOS chip is captured in a dark environment and is processed, stored and deleted from captured images to reduce noise and improve the overall image quality.
    Another embodiment of the apparatus for producing an image of an eye allows use in a switchable normal focus or plenooptic mode to allow the capture of images from multiple focal planes.
    Another embodiment of the apparatus for producing an image of an eye uses an optical stereo system for real-time stereoscopic visualization. This is accomplished in a variety of different ways including optical alteration, CCD lens overlay or microlens overlay and can be derived from video scanning, motion and/or focusing cameras, multiple cameras, or multi-chip cameras.
    Another embodiment of the apparatus for producing an image of an eye has dual stereo cameras (or two chips/optics in a single camera). These can be mounted to the slit lamp via the beam-splitter or eyepieces of a traditional slit lamp beam-splitter.
    Another embodiment of the apparatus for producing an image of an eye involves an alternative to a fast alternating strobile of an LED light that uses an optically rotating mask at a fast rate that is synchronized to a video input. This would result in multiple images for artifact-free reconstruction.
    Another embodiment of the apparatus for producing an image of an eye uses a rotating light source which can also be used in combination with the other features mentioned above. This can be done with various optical elements in the apparatus to produce an image of an eye including a synchronized fast rotating optic such as a wedge prism. The artifact is mapped to the other image to remove the artifact. Mapping can be done with image processing or with real-time calibration and memory mapping. Mapping also serves as a means of increasing the image's field of view and can be put together in a panorama as a single image.
    Another embodiment of the apparatus for producing an image of an eye uses any or all of the described elements and jointly produces a real-time panorama of the video stream. This can also be achieved by a pre-programmed random or automatic change in patient fixation. This can also be achieved through a programmable balance and/or tilt of the device to change the position and image display.
    Figure A illustrates an exploded perspective view of an apparatus for producing an image of an eye 100, in accordance with one embodiment of the present invention. Apparatus for producing an image of an eye 100 includes a video camera 110, video camera optics 112, a camera housing 120 mounted on a chin rest bar and slit lamp 130 configuration, and light source optics 140. The video camera 110 is a digital camera but can be any type of camera suitable for use with the device to produce an image of an eye 100. The chin rest bar and slit lamp 130 configuration includes a chin rest holder. the head 142, a movable base 144, a bar 146, and a housing support 148. The head support 142 holds the patient's chin and forehead in a known fixed position. Headrest 142 is provided with elevation adjustments to provide a comfortable resting place for the patient's head. The position of the camera housing 120 relative to the head support 142 can be adjusted in both coarse and fine relative increments using bar 146. The apparatus for producing an image of an eye 100 is used in combination with a computer system 150, which is described in more detail in figure 1D. Computer system 150 can be any suitable computer system 150 that can be used in combination with eye examination apparatus 100.
    The personal computer 150 forms the center of the ocular imaging apparatus 100, processing data and controlling the operation of other components of the eye examination apparatus 100. Connected to the personal computer 150 is a video camera 110. An observational video monitor , which may be the personal computer screen, a chin rest bar and slit lamp 130, light source optics 140, and video camera optics 112 are associated with the camera housing 120.
    Personal computer 150 is preferably a relatively compact computer, embedded computer, or tablet computer of relatively high processing power using a standardized operating system and with standardized card slots for interconnecting peripheral equipment such as memory cards, video card, printer and a monitor. Personal computer 150 runs custom software as will be described in detail later. The monitor or screen of the personal computer has high resolution color graphics capability suitable for displaying the images under analysis.
    The digital card accepts a digital file or video input from a video camera 110 and functions as a "capture" or display card. That is, when activated by a signal from the personal computer 150, the digital board collects the video and/or digital data and images from the video camera 110 at that time and stores it in digital data. The digital data produced is stored in memory and made available to the personal computer 150 for analysis.
    Figure 1B shows a side perspective view of a camera housing 120 of the chin rest bar assembly 130, in accordance with one embodiment of the present invention. The camera housing 120 which contains the video camera 110, light source and optics 140 is proximate to a sectioned eyeball of the patient EB with a cornea C and retina R. Housing 120 may be cylindrical or any other suitable shape. The housing 120 has no forward protruding parts, which prevents accidental direct contact of any part of the Eye Imaging apparatus 100 with the patient's cornea C or facial features during movement of the housing 120 relative to the patient's eyes. This is advantageous since there is no contact with the patient's cornea C to perform the examination and image capture. The 120 outer housing and lenses are designed to maintain some distance from cornea C, increasing patient comfort while any test is being performed. A flexible interface such as a rubber cup 180 may be provided at the interface between housing 120 and the patient's eyeball EB.
    The inclusion of light source optics 140, camera optics 112 and video camera 110 in the housing of camera 120 provides a high degree of accessibility. By placing all the elements of the eye imaging apparatus 100 in a camera housing 120, it allows for an affordable design. Additionally, the relatively small design of the ocular imaging apparatus 100 compared to a background camera for observation and image capture provides a shorter and more efficient optical path. The compact design and simplicity of the 112, 140 optics reduces production costs and allows for greater operator ease of use. The design of the ocular imaging apparatus 100 allows imaging through a smaller pupil compared to a background camera.
    The video camera 110 is relatively compact and incorporates a color sensor or CCD sensor, monochrome CMOS, or multi/hyper-spectral image sensor. Patient focus can also be achieved by focusing the digital camera's internal optical elements. The lens contained within the camera 100 can be focused automatically or manually by observing the image displayed on the observation video monitor. Alternatively, an electronic autofocus control system can be provided to automatically adjust the focus of the lens within the camera 100. The video camera 110 can also contain a monochrome or color or CCD or CMOS sensor (not shown).
    The observation lens 112 associated with the video camera 110 includes the lens 170, an observation aperture 172, and a filter 174. The observation aperture 172 and filter 174 transmit light reflected from the retina R to the lens 170 and to the video camera 110. Filter 174 is an infrared enhancement filter (or other filter for other imaging procedures), which improves the contrast of the image seen by video camera 110.
    Indo-cyanine green angiography, background color photography, autofluorescence angiography or fluorescein, curcumin fluorescence imaging, or other sets of filters can be used by the eye imaging apparatus 100. These filters are mounted in a fashion. to be selectively rotated in and out of the video camera 110's axis of view in accordance with the function to be performed. Rotation can be performed manually or under computer control.
    The projection lens 140 of the invention projects light onto the retina R, off-axis at an angle to the central axis 176 of the lens 170 of the video camera 110. The projection lens 140 includes a lamp 141, a lamp assembly of lens 143, a mirror 145, and a projection aperture 172. A control 1001 is provided to adjust the intensity and position of the lamp 141, either manually or under the control of computer system 150. The control is also used to sequentially control the lamps. multiple lamps 141, displacing optical elements, inversion masks 147, internal fixation pointer LED 1004, and image capture trigger.
    Light from lamp 141 passes through aperture 149 and the series of lamp lens group 143 which typically has two lenses. The lenses of the lamp lens group 143 concentrate the light output from the lamp 141. The lamp lens group 143 may preferably consist of multiple lenses or a single aspherical lens. The light is then deflected by mirror 145 which is placed at a critical tilt angle relative to video camera 110 and projection lens 112.
    The light passes from the mirror 145 past the inversion mask 147 which concentrates the light. The light then passes through a plurality of small pupil masks 1002. The light then passes through the objective lens 1003. The light then passes through the cornea C and is projected onto the retina R.
    All masks and apertures used, such as inversion mask 147 and aperture 149 and 1002, are appropriately sized apertures. Although lamp 141 has been described as a generalized LED lamp 15, it should be noted that lamp 141 can be any source of radiant energy. In a preferred embodiment, lamp 141 is an infrared illumination source, and filter 174 specifications are adjusted accordingly to pass the wavelength of lamp 141. Infrared illumination may be particularly desirable for alignment prior to acquisition. of images without the problems generated by lack of pupil dilation. The image can be captured in a relatively dark room with infrared illumination so that the eye being examined is naturally dilated. There is also a means for sequentially transforming the light source on and off in synchronization with the image capture in each condition, which is a computer system 150, further described in Fig. 1C.
    In another preferred embodiment that addresses the problems caused by the lack of pupil dilation during imaging, lamp 141 can be in vibrant color, free red, NIR, or another required wavelength (based on the desired imaging procedure) during image acquisition rather than being held constant, thereby preventing the lamp energy 141 from narrowing the pupil before image capture. Due to the unique design of the 140 projection lens and the image processing capabilities and analysis software employed, useful image data from each image can be collected with minimal pupil dilation. Specifically, the pupils of the eye being examined can have a diameter of at least 2 mms. Projection lens 140 projects light onto the retina R off axis of the observation path of video camera 110. Another preferred embodiment places an adjustable mask 1002 adjacent to objective lens 1003 which adjusts the patient's pupil to optimize the image when the pupil is small.
    Figure 1C illustrates a top perspective front view of an eyeball 180, in accordance with one embodiment of the present invention. Eyeball 180 protrudes outward from perimeter 182 at an approximate 10% increase at the approximate positions of 0° degree 184 and 180° degrees 186 at perimeter 182. Further details about eyeball 180 are described in Figure 3 and its description.
    Figure 1D is a lateral diagonal exploded perspective diagram of a computer system 150 in accordance with one embodiment of the present invention. Said computer system 150 includes a processing unit such as a CPU 151 connected by a bus to a random access memory or RAM 152, a storage device 153, a keyboard 154, a display 155 and a mouse 156. there is data entry software 157 incorporating the ocular imaging apparatus 100. An example of a computer system 150 may be a Dell personal operating computer running on the Microsoft Windows operating system, or Linux, Macintosh, etc. The invention can also be used on a laptop computer, cell phone, PDA, Apple™, Mac™ tablet or other computerized device. Computer system 150 can also be used in combination with a wireless modem 158 or network interface card 159.
    The various embodiments of the method of the invention will generally be implemented by a computer executing a sequence of program instructions to carry out the method steps, assuming that all data necessary for processing is accessible to the computer. The sequence of program instructions may be incorporated into a computer program product comprising means that store the program instructions. As will be readily apparent to those skilled in the art, the present invention can be embodied in hardware, software, or a combination of hardware and software. Any type of computer/server system - or other apparatus adapted to carry out the methods described herein is suitable. A typical combination of hardware and software might be a general purpose computer system with a computer program that, when loaded and executed, performs the method, and variations of the method as described herein.
    Figure 2 illustrates a side perspective view of an ocular imaging apparatus 200 used in combination with a microscope 260, in accordance with one embodiment of the present invention. Figure 2 illustrates a side perspective view of an eye imaging apparatus 100 that has all the same components as the eye imaging apparatus 100 described in Figure 1A, except for the microscope 260 and computer system 150. The apparatus for producing an image of an eye 200 includes a video camera 210, video camera lenses 212, a camera housing 220 mounted on a patient alignment assembly 230, and an illumination source lens 240. The microscope assembly 230 includes a bracket 242. a movable base 244, and housing support 248. The position of the camera housing 220 relative to the head support 242 can be adjusted in coarse and fine increments using the bar 246. The microscope 260 can be any suitable microscope that can be used in combination with the One-Eye Imaging Apparatus 200.
    Figure 3 illustrates a side perspective view of a portable eye imaging apparatus 300, in accordance with one embodiment of the present invention. The portable one-eye imaging apparatus 300 includes all of the same components as the ocular imaging apparatus 100 described in Fig. 1B and can be used in combination with a microscope 260 (Fig. 2) or a computer system 150 (Fig. IA). The portable one-eye imaging apparatus 300 uses a portable housing 310 instead of a camera housing 120 as described in Figure 1A and 1B, but uses all the same optical and electrical components disposed within the portable housing 310.
    The portable apparatus for producing an image of an eye 300 may also utilize a flexible eyeball 320 which can be attached to the portable apparatus for producing an image of an eye 300, or be used as a flexible disposable eyeball that connects to end 312 of the apparatus to produce an image of an eye for use with each patient. The flexible eyeball 320 can be made of a flexible material 322 such as plastic, rubber, or any suitable type of material that gently wraps the patient's eye to create a dark environment and can also be used to hold a patient's eyelids open. Flexible eyeball 320 may have an angled inner spring mechanism 330 that holds the patient's eyelids open. The 322 deflectors are flexible to allow for adjustable and proper positioning around the patient's eye.
    Figure 4A is a flowchart of a method for producing an image of an eye 400, in accordance with one embodiment of the present invention. Method 400 generally illustrates the architecture, functionality, and operation of possible implementations of computer program systems, methods, and products in accordance with various embodiments of the present invention. In this sense, each step in the method can represent a module, segment, or piece of code, which comprises one or more executable instructions to implement the specified logic function. It should also be noted that, in some alternative implementations, the functions observed in the step may occur out of order. For example, two steps shown in succession may in fact be performed substantially simultaneously, or the steps may sometimes be performed in reverse order, depending on the functionality involved. It will also be noted that each step of the method in general, and combinations of steps in the method in general, can be implemented by special purpose hardware systems that perform the specified functions or acts, or combinations of special purpose hardware and computer instructions .
    The method in general can be embodied as a system, method or computer program product. Therefore, the method in general can take the form of a hardware embodiment, a software embodiment, or a combined software and hardware embodiment. Furthermore, the method in general may take the form of a computer program product incorporated in any tangible means of expression having the usable computer program code incorporated in the medium.
    Any combination of one or more usable or readable computer media can be used. Specific examples of the computer readable medium may include a hard disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM), or flash memory or read-only memory. portable compact disk (CD-ROM). In the context of this document, a usable or readable computer medium can be any medium that can be used by or in connection with the instruction execution system or apparatus. Computer program code for performing general method operations can be written in any combination of one or more programming languages. Program code can run entirely on the user's computer, partially on the user's computer as a standalone software package, partially on the user's computer, and partially on a remote computer, or entirely on the remote computer or server.
    The method in general is described above with reference to a computer program according to an embodiment of the present invention. It should be understood that each step, and combinations of the steps shown, can be implemented by computer program instructions. These computer program instructions may be provided to a general purpose computer processor, purpose-built computer, or other programmable data processing apparatus to produce a machine such that instructions are executed through the processor. of the computer or other programmable data processing apparatus, create means to implement the functions specified in the method.
    These computer program instructions may also be stored on a computer readable medium which can direct a computer or other programmable data processing apparatus to function in a particular manner such that instructions stored on the computer readable medium produce a factory item including means of instructions that implement the function specified in the steps.
    The computer program instruction may also be loaded into a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions performed on the computer or other programmable device provide processes for implementing the specified functions.
    In the first step 410, the patient's demographics are entered. The patient places their head in the slit lamp on the bar structure and chin rest so that the patient's head is kept substantially immobile. The operator adjusts the position of the housing using adjustments to the bar assembly and chin rest and particularly using the bar until the projection lens and video camera are aimed at either cornea of the patient's eye. Image capture is initiated 420 and is triggered by the operator, or automatically by the computer based on an optimal image alignment algorithm by the operator pressing a button on the bar, Bluetooth keyboard, tablet, or pressing a footswitch to signal the device that the image of the camcorder must be recorded. Then, an autofocus and autoexposure procedure 430, 440 is performed to obtain a clear image of the patient's retina. The illumination is then activated 450 and, thus, both the activated optical shift 460 and the inversion mask 147 (from figure 1B) are actuated (depending on the configuration).
    Figure 4B illustrates a front perspective view of an eye capture image 472 and artifact points 480, in accordance with one embodiment of the present invention. Afterwards, the image capture ends 470 and artifacts are identified 480.
    Figure 4C illustrates a front perspective view of an inversion mask 485 in an image capture of the eye 490, in accordance with one embodiment of the present invention. After identifying the artifacts, the inversion mask 147 is identified, the additional well-exposed focused parts of each image are identified 490, and the image parts are combined to create a composite image without artifact 495. Figure 4D illustrates a front perspective view of the composite image of the artifact-free eye 495, according to one embodiment of the present invention. The composite image without artifact 495 is previously depicted in Figure 4C.
    In response to indication from the operator (or via the controller) the image must be recorded, the personal computer causes the video camera image to store digital data representing the captured image. The method in general 400 can also be used in combination with a microscope. The method can generally be used with the verification device through a rocking or tilting mechanism or patient fixation.
    While the present invention has been related in terms of previous embodiments, those skilled in the art will recognize that the invention is not limited to the described embodiments. The present invention may be practiced with modifications and alterations within the spirit and scope of its claims. Therefore, the description is to be considered as illustrative rather than restrictive in the present invention.
    权利要求:
    Claims (23)
    [0001]
    1. Apparatus that produces an image of a posterior or anterior segment of the eye (100) comprising: - a light source (141); - an optical system (140) with a center having optical elements that can be displaced to provide light from said light source in an optical axis or slightly off said optical axis from said center of the optical system and return an image path of the said posterior and anterior segment; characterized by, - a means for sequentially turning on and off said light source in synchronization with the image capture in each condition; - a means for inserting an inversion mask (147) which momentarily blocks unwanted reflections in small areas of an image, leaving larger areas of the image illuminated; - a means for detecting said artifacts (480) in one image (without inversion mask), and detecting said artifact mask in the second image, and combining the images to create a composite image (495) without artifact; - a means for tilting or rocking the optical head, altering the patient's fixation to generate views with artifacts at different locations in each image, patterned images or film stream, and - a plurality of optical displacement elements, masks and light sources wherein two or more images have specular and reflex artifacts located in two or more anatomically different areas of each sequentially acquired image of said eye segments are created, said artifacts in said images are detected by image processing, said images are combined with one or more images to create a composite image, a stereo image, a multi-image panoramic image or video stream, or generate a video stream by shifting the retina without artifacts, where parts of the relatively clear well-focused image are combined into one or further said images or video streams to create said composite image or film.
    [0002]
    Apparatus according to claim 1, characterized in that said light source is momentarily and laterally displaced to generate artifacts in different locations.
    [0003]
    3. Apparatus according to claim 2, characterized in that said light source is laterally displaced and rotated, synchronized with image capture to generate artifacts in different locations.
    [0004]
    Apparatus according to claim 3, characterized in that said light source has at least two or more light sources that are fired sequentially, generating artifacts in different locations.
    [0005]
    Apparatus according to claim 1, characterized in that said alternative image illumination paths enter said pupil at an angle relative to said optical center axis but are displaced by optical elements to create artifacts at different locations.
    [0006]
    Apparatus according to claim 5, characterized in that said position of light sources and said image paths are of variable size, position and shape depending on pupil size and can be adjusted manually or automatically dynamically, in combination with apertures and masks based on pupil size and desired field of view.
    [0007]
    Apparatus according to claim 6, characterized in that a spatial light modulator is provided to position and shape said light source in accordance with said detected location and dimensions of said pupil.
    [0008]
    8. Apparatus according to claim 6, characterized in that an IR filter or near IR or light source is provided to allow non-mydriatic operation, align and rotate to allow other spectral wavelengths to pass and allow capture of subsequent imaging with visible light or specifically defined wavelengths.
    [0009]
    The apparatus of claim 6, characterized in that a flexible eyeball (180) made of flexible material is positioned to enclose said eye to create a dark environment with compressible protruding features (184, 186) at the 6 and 12h positions used to hold a person's eyelids open during such eye imaging.
    [0010]
    Apparatus according to claim 6, characterized in that said focus is varied and spaced to allow capture in multiple focal planes in said eye and recombined into a single image, a plenotic image, a stereo image, or a film.
    [0011]
    Apparatus according to claim 6, characterized in that said focus is varied by a series of microlenses of different focal lengths and is placed on an image sensor and said images subsequently captured at multiple focal lengths.
    [0012]
    Apparatus according to claim 11, characterized in that said apparatus is connected to or combined with an existing slit lamp, a microscope, an OCT device, a direct ophthalmoscope, an indirect ophthalmoscope, an adaptive optical imaging device , or a background camera and using a portion of said imaging elements to capture and process said image.
    [0013]
    Apparatus according to claim 12, characterized in that said apparatus is equipped with said light sources and filters using color background imaging, fluorescein angiography, free red, red, blue, ICG angiography, all lengths waveform autofluorescence, flavoprotein fluorescence, 2-photon imaging, curcumin fluorescence imaging, multispectral imaging, hyperspectral imaging, functional imaging, lens imaging, corneal and other anterior segment imaging, film imaging tear, optical coherence tomography, dark adaptation rod and coniform sensitivity testing, microperimetry, optical name character recognition, and ultra-wide field imaging, and which also serves as a guidance and planning system to address various conditions.
    [0014]
    Apparatus according to claim 13, characterized in that said apparatus is used to detect amyloid in said retina.
    [0015]
    Apparatus according to claim 14, characterized in that said apparatus contains an internal fixation pointer containing LEDS, a motorized tilt and balance mechanism for moving said retina and a set of masks that dynamically adjusts the small pupils and creates still images, patterned images, or movies.
    [0016]
    Apparatus according to claim 1, characterized in that said means for sequentially connecting said light source and one or more cameras is a computer system or a tablet computer which is turned on and off in synchronization with said masks inversion and lens with image capture in each of said conditions.
    [0017]
    17. Apparatus according to claim 1, characterized in that said apparatus is used in combination or integrated with an OCT device, a microscope, a slit lamp, a direct or indirect ophthalmoscope, a microperimetry device, or a camera of existing fund.
    [0018]
    Apparatus according to claim 1, characterized in that said device has a portable housing (310) and is used as a portable device (300) either as a stand-alone device or incorporated with an existing direct or indirect ophthalmoscope.
    [0019]
    19. A computerized method for producing an image of an anterior and posterior segment of an eye in combination with the imaging apparatus, comprising the steps of: -entering patient demographic data (410); - start image or movie capture (420); - optimize the position of masks and illumination for pupil size autofocus, or intentional focus shift for plenoptic imaging; - perform auto exposure (440); the method being characterized by: - activating sequential lighting (450); - activate optical change; - activate the inversion mask (460); - finish image or movie capture (470); - identify artifacts (480), masks and clear parts of images; - identify (490) the relatively well-focused and well-lit parts of said images; and - combining (495) the parts of said image to create a composite image/film without artifact, plenoptic, patterned, or stereo.
    [0020]
    A method according to claim 19, characterized in that said apparatus is a portable apparatus (300) either as a stand-alone device or incorporated with an existing direct or indirect ophthalmoscope.
    [0021]
    21. A method according to claim 19, characterized in that said apparatus is used in combination with a microscope, a slit lamp, an OCT, a microscope, a direct or indirect ophthalmoscope, a micro perimetry device, or a existing background camera.
    [0022]
    A method according to claim 19, characterized in that said apparatus is used in detecting amyloid in said retina.
    [0023]
    A method according to claim 22, characterized in that said apparatus is used in said detection of amyloid in said retina using light sources, filters, spectrometers and sensors that allow curcumin fluorescence imaging, auto fluorescence imaging, imaging hyper-spectral, multi-spectral imaging or OCT and subsequent segmentation for identification of amyloid associated with ocular or brain conditions.
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    同族专利:
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    CN102917634A|2013-02-06|
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    WO2011119602A3|2011-12-22|
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    IL222047A|2017-12-31|
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    ES2601886T3|2017-02-16|
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    WO2011119602A2|2011-09-29|
    AU2011232625A1|2012-09-27|
    KR20130010079A|2013-01-25|
    EP2549913A4|2014-03-26|
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    JP5566523B2|2014-08-06|
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    US9314155B2|2016-04-19|
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    BR112012023716A2|2018-05-15|
    EP2549913B1|2016-09-07|
    US20110234977A1|2011-09-29|
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    法律状态:
    2018-07-03| B25A| Requested transfer of rights approved|Owner name: NEUROVISION IMAGING LLC (US) |
    2018-07-24| B08E| Application fees: payment of additional fee required [chapter 8.5 patent gazette]|Free format text: COMPLEMENTAR A RETRIBUICAO DA(S) 4A. ANUIDADE(S), DE ACORDO COM TABELA VIGENTE, REFERENTE A(S) GUIA(S) DE RECOLHIMENTO 0000221404926130. |
    2018-10-23| B08F| Application fees: application dismissed [chapter 8.6 patent gazette]|Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. |
    2019-01-15| B08G| Application fees: restoration [chapter 8.7 patent gazette]|
    2019-01-22| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2020-01-21| B25D| Requested change of name of applicant approved|Owner name: NEUROVISION IMAGING INC. (US) |
    2020-07-21| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-05-25| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-07-13| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |
    优先权:
    申请号 | 申请日 | 专利标题
    US31667710P| true| 2010-03-23|2010-03-23|
    US61/316,677|2010-03-23|
    PCT/US2011/029421|WO2011119602A2|2010-03-23|2011-03-22|Apparatus and method for imaging an eye|
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