巴西专利BR112012020829B1 liquid drug transfer device for use with a medical bottle

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引用文献

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专利摘要:
liquid drug transfer device with ventilated bottle adapter. the present invention to liquid drug transfer devices including a ventilated vial adapter having an upper wall, a downwardly dependent tip, and a double lumen perforating tip. the upper wall includes ventilation openings in fluid communication with an underlying air filter and protective covers to protect the ventilation openings from splashing. the cover-shaped covers are preferably in the form of a quarter of spheres with the cover openings facing radially downwards.
公开号:BR112012020829B1
申请号:R112012020829
申请日:2011-02-23
公开日:2020-04-14
发明作者:Lev Nimrod
申请人:Medimop Medical Projects Ltd；
IPC主号:

专利说明:

Invention Patent Description Report for NET DRUG TRANSFER DEVICE FOR USE WITH A MEDICINAL BOTTLE.
Field of the invention [0001] The invention relates to liquid drug transfer devices in general and liquid drug transfer devices including a ventilated vial adapter in particular.
Background of the invention [0002] United States Patent No. 6,139,534 to Niedospial,
Jr. et al. illustrates and describes a liquid drug transfer device consisting of a ventilated vial adapter having a longitudinal vial axis and including an upper wall with a series of axially directed vents, an annular air filter underlying the series of vents , a downwardly dependent tip to telescopically receive a vial in it, a downwardly dependent central double lumen perforating tip and an oppositely directed central liquid transfer port. The piercing tip of the double lumen includes a pair of adjacent axial lumens, namely, a liquid transfer lumen and a ventilation lumen. The liquid transfer port is in fluid communication with the liquid transfer lumen. The ventilation openings are in fluid communication with the ventilation lumen through the air filter. The ventilated bottle adapter includes an elastomeric pre-branching septum to maintain sterility of the bottle contents. The use of the ventilated vial adapter can lead to liquid drug contents inadvertently draining into one or more of the ventilation openings or one or more ventilation openings being splashed by the liquid drug contents, thereby moistening the underlying air filter at the expense of its operation.
Petition 870190110374, of 10/30/2019, p. 4/15
2/5 [0003] Liquid drug transfer devices with ventilated vial adapters are also illustrated and described in inter alia US Patent No. 4,834,744 to Ritson, US Patent Nos. 6,503,240, 6,544,246, 6,655,246, 6,997,917 and 7,799,009 also for Niedospial, Jr. et al., U.S. Patent No. 7,192,423 to Wong, U.S. Patent No. 7,452,348 to Hasegawa, U.S. Patent Application Publication No. US 2007/0156112 to Walsh, U.S. Patent Application Publication No. US 2008/0172024 to Yow.
Summary of the invention [0004] The present invention is directed to liquid drug transfer devices including a vented bottle adapter described so far. The present invention is directed to providing such a ventilated vial adapter with individual protective covers to protect its ventilation openings to exclude liquid drug contents that enter a ventilation opening due to drain, splash and the like, and dampening your filter of air underlying the detriment of its operation. The present invention can include a lid manually placed to place on a liquid access port to maintain the sterility of the contents. Alternatively, the present invention may include an elastomeric pre-branching septum to maintain the sterility of the contents of the vial.
[0005] The present invention can also be applied to a wide range of liquid drug transfer devices including ventilated vial adapters for use with vials of different sizes, namely, 13mm, 20mm, and the like. Liquid drug transfer devices may consist of vial adapters including female vial adapters, male vial adapters, and the like. Other devices
Petition 870190110374, of 10/30/2019, p. 5/15
3/5 liquid drug transfer devices include, for example, liquid drug transfer devices illustrated and generally described in U.S. Patent No. 6,558,365 to Zinger et al., Online liquid drug transfer devices illustrated and generally described in the publication PCT International No. WO 2005/105014, and the like.
Brief Description of the Drawings [0006] To understand the invention and to see how it can be carried out in practice, preferred embodiments will now be described, in the form of non-limiting examples only with reference to the accompanying drawings in which similar parts have similar numbers, and in what:
figure 1 is a pictorial representation of a syringe, a vial and a female vented vial adapter having a longitudinal vial axis;
Figure 2 is a top plan view of the vented bottle adapter along the axis of the longitudinal bottle;
figure 3 is a longitudinal cross-section of the vented bottle adapter of figure 1 along line A-A in figure 2;
figure 4 is a longitudinal cross-section of the vented bottle adapter of figure 1 along line B-B in figure 2; and Figure 5 is a pictorial representation of a liquid drug transfer device with a removable vented vial adapter.
Detailed description of the preferred embodiments of the Invention [0007] Figure 1 shows a syringe 10 constituting a source of physiological fluid, a medical vial 20 and a liquid drug transfer device 30 consisting of a female ventilated vial adapter for use with the syringe 10 and vial 20. Syringe 10 includes a cylinder 11 with a plunger 12 and a Luer connector
Petition 870190110374, of 10/30/2019, p. 6/15
4/5 male 13. Syringe 10 can be formed with other types of male connectors. Vial 20 includes an open covered bottle 21 sealed by a lid of vial 22 protected by a metal strip 23. Vial 20 contains a powdered drug or liquid drug 24 under negative pressure. Syringe 10 typically contains diluent to reconstitute the contents of vial 24.
[0008] Figures 1 to 4 show the female vented bottle adapter 30 which has a longitudinal bottle axis 31 and includes a transverse upper wall 32 having a downward dependent tip 33 with flexible members 34 for fitting to the bottle 20. The adapter of the bottle 30 includes a puncture tip dependent down from the double lumen 36 to pierce the cap of the bottle 22 by engaging the tip 33 in the bottle 20. The piercing tip 36 includes a base 36A towards the upper wall 32 and ends at one end of the tip 36B. The drill tip 36 includes a pair of axial lumens, namely, a liquid transfer lumen 37 and a ventilation lumen 38. The liquid transfer lumen 37 includes a port 37A towards the end of the tip 36B. The ventilation lumen 38 has a port 38A towards the end of the tip 36B.
[0009] The bottle adapter 30 also includes a central axial liquid transfer port 39 opposite to the drill tip 36 and in fluid communication with the liquid transfer lumen 37. The liquid transfer port 39 ends at a Luer connector female 41 for thread coupling with the male Luer connector 13 of the syringe. The bottle adapter 30 includes a manually placed cap 42 to seal the female Luer connector 41.
[00010] The upper wall 32 includes a pair of diametrical opposed axial ventilation openings 43. An annular air filter 44 is
Petition 870190110374, of 10/30/2019, p. 7/15
5/5 arranged under the upper wall 32. The ventilation openings 43 are in fluid communication with the ventilation lumen 38 through the air filter 44. The air filter 44 filters the intake of extracted air in the vial 20 in the perforation of the lid of bottle 22.
[00011] The upper wall 32 is formed with a pair of protective covers 46 mounted on the ventilation openings 43 to protect the ventilation openings 43 in the top plan view of figure 2. The protective covers 46 are preferably formed of a quarter sphere . The protective caps 46 have a lid opening 47 above the upper wall 32 and facing radially outwardly with respect to the longitudinal vial axis 31. The protective caps 46 inadvertently exclude liquid drug contents that moisten the air filter 44 through the ventilation openings 43 when using the bottle adapter 30.
[00012] Figure 5 shows a liquid drug transfer device 50 of U.S. Patent No. 6,558,365 with a detachable vented bottle adapter 51 similar to the vented bottle adapter 30.
[00013] While the invention has been described with respect to a limited number of modalities, it will be appreciated that many variations, modifications and other applications of the invention can be included within the scope of the appended claims.

权利要求:
Claims (3)
[1]
1. Liquid drug transfer device (30) for use with a medical bottle (20) including a bottle containing a medicine, a bottle opening interrupted by a bottle cap, and a narrow neck that intermediate the bottle and the bottle opening vial, the liquid drug transfer device comprising a vented vial adapter (30) having a longitudinal vial axis (31) and including an upper wall (32) transverse to said longitudinal axis, a substantially cylindrical edge (33) having members flexible (34) resiliently attached to said upper and down wall depending on this to receive the opening of the bottle in a telescopic and sliding way, an annular air filter (44) disposed under said upper wall, a double lumen perforating tip downwardly dependent (36) to pierce the bottle cap (22) to establish fluid communication with the inner bottle, said piercing tip having a b ase (36A) adjacent to said upper wall and a piercing end (36b), said piercing end including a pair of axial directed lumens extending from said base to said piercing end, said pair of axial directed lumens including a liquid transfer lumen (37) and a ventilation lumen (38), a liquid transfer port (37A) in fluid communication with said liquid transfer lumen, at least one axial directed ventilation opening (43) formed in said upper wall and in fluid communication with said ventilation lumen through said air filter, said liquid transfer port and said at least one ventilation opening being in fluid communication with the
Petition 870190110374, of 10/30/2019, p. 9/15
[2]
2/2 bottle slidingly receiving the bottle in the bottle adapter characterized by the fact that said upper wall is formed with a corresponding number of at least one protective cover as at least one said ventilation opening so that each ventilation opening of said at least one vent opening is individually covered by a respective protective cover (46) of said corresponding number of at least one protective cover in a top plan view of said vented bottle adapter along said longitudinal bottle axis and each said protective cover is formed on said upper wall and has a cover opening (47) facing radially outwards in relation to said longitudinal bottle axis.
2. Device according to claim 1, characterized by the fact that each said protective cover has a quarter-sphere shape.
[3]
Device according to claim 1 or 2, characterized by the fact that it still comprises a manually placed lid (42) to seal said liquid access door.

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法律状态:
2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|

2019-08-06| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|

2020-02-27| B09A| Decision: intention to grant|

2020-04-14| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/02/2011, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

IL20414110|2010-02-24|

IL20910110A|IL209101D0|2010-11-04|2010-11-04|Vented vial adapter|

PCT/IL2011/000187|WO2011104712A1|2010-02-24|2011-02-23|Liquid drug transfer device with vented vial adapter|

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