• 专利附录
  • 专利说明
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    • 专利摘要:
    INJECTION PEN WITH LAST DOSE MEASUREMENT AND CONTROL REFLUX. A medication injection pen is provided comprising a housing (218) for housing a dose adjustment knob (220), a lead screw (226), a conductor (224), a recoil element (222) and an element stop dose (228). The dose adjustment knob (220) is rotatable with respect to said housing (218) to set a desired injection dose and comprises at least one internal thread (291). The lead screw (226) includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that which expels medication from a cartridge (36). The conductor (224) is rotationally fixed on said lead screw (226) to prevent relative rotation between them, said lead (224) being rotatable in a first direction to rotate and advance said lead screw (226) in the said first direction. The recoil member (222) is pivotally secured to said conductor (224) to prevent relative rotation therebetween. The dose stop member (228) is rotationally coupled to said recoil member (222) and comprises an external thread (290) in engagement with said internal thread (291) of said (...).
    公开号:BR112012013340B1
    申请号:R112012013340-3
    申请日:2010-11-30
    公开日:2021-05-04
    发明作者:Richard Cronenberg；Michael Quinn；Haiming Wu
    申请人:Becton, Dickinson And Company；
    IPC主号:
    专利说明:

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    [001] This application claims the benefit of U.S. Provisional Patent Applications 61/265,562, filed December 1, 2009 and 61/351,465, filed June 4, 2010, each of which is incorporated herein in its entirety. field of invention
    [002] The present application relates to multi-dose medication injection pen devices with improved functionality, including improved reflow metering of an adjusted dose and improved last dose control. Invention precedents
    [003] Various medication injection pen devices are known in the prior art. These prior art devices sometimes include features to enable a user to correct a dose that has been set too large, which may be referred to as "measurement reflux". Another aspect that may be provided by some of the prior art devices is the ability to control a last dose from a medication cartridge, such that a user cannot adjust a dose greater than the amount of medication remaining in the cartridge. This aspect is referred to as last dose control or last dose management. Both of these aspects are desired by users of such pen devices; however, prior art devices do not satisfactorily meet these needs. Many prior art devices can provide one of these aspects, but not both. In addition, many of the prior art devices require additional steps to perform measurement reflow, which are cumbersome and unintuitive for the user. Thus, there is a need in the art to provide improved backflow metering functionality and last dose control mechanisms together in a medication injection pen. Summary of the embodiments of the invention
    [004] Exemplary embodiments of the present invention address at least the above problems and/or disadvantages and provide at least the advantages described below.
    [005] Thus, a first exemplary embodiment of the present invention provides a medication injection pen comprising a housing for housing a dose adjustment knob, a lead screw, a trigger, a recoil member and an interruption member of dose. The dose adjustment knob is rotatable with respect to said housing to set a desired injection dose and comprises at least one internal thread. The lead screw includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that expelling medication from a cartridge. The actuator is rotationally fixed on said lead screw to prevent relative rotation therebetween, said actuator being rotatable in a first direction to rotate and advance said lead screw in said first direction. The recoil member is fixed with rotation on said actuator to prevent relative rotation between them. The dose interrupt member is rotatably secured to said recoil member and comprises an external thread in threaded engagement with said internal thread of said dose adjustment knob, said dose interrupt member being axially movable with respect to said dose adjustment knob when said dose adjustment knob is rotated relative to said recoil member, and wherein axial movement of said dose stop member limits user adjustment of a dose that is greater than one. injectable volume of medication that remains in the cartridge.
    [006] According to another exemplary embodiment of the present invention, a medication injection pen is provided comprising a housing for housing a dose adjustment knob, a lead screw, a trigger, a recoil member and a member of dose interruption. The dose adjustment knob is rotatable with respect to said housing to set a desired injection dose. The lead screw includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that which expels medication from a cartridge. The actuator is rotatably fixed on said lead screw to prevent relative rotation therebetween, said actuator being rotatable in a first direction to rotate and advance said lead screw in said first direction. The recoil member is fixed with rotation on said actuator to prevent relative rotation between them and is provided with an external thread thereon. The dose interrupt member is rotatably secured to said dose adjustment knob and comprises an internal thread in threaded engagement with said external thread of said recoil member, said dose interrupt member being axially movable with respect to said dose adjustment knob when said dose adjustment knob is rotated relative to said recoil member, and wherein axial movement of said dose stop member limits user adjustment of a dose that is greater than one. injectable volume of medication that remains in the cartridge.
    [007] According to yet another exemplary embodiment of the present invention, a medication injection pen is provided comprising a housing, for housing a dose adjustment knob, a lead screw, a trigger, a member of recoil and a dose-interrupting member. The dose adjustment knob is rotatable with respect to said housing to set a desired injection dose. The lead screw includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that which expels medication from a cartridge. The driver is rotationally fixed on said lead screw to prevent relative rotation therebetween, said drive being rotatable in a first direction to rotate and advance said lead screw in said first direction. The recoil member is rotationally fixed on said actuator to prevent relative rotation between them. The dose interrupt member is rotatably fixed to said dose setting knob and comprises an internal thread in threaded engagement with said thread of said lead screw, said dose interrupt member being axially movable with respect to said knob. setting dose when said dose setting knob is rotated relative to said recoil member, and wherein axial movement of said dose stopping member limits user adjustment of a dose that is greater than one. injectable volume of medication that remains in the cartridge.
    [008] According to yet another exemplary embodiment of the present invention, a medication injection pen is provided comprising a housing, for housing a dose adjustment knob, a lead screw, an actuator, a member of indentation and a tongue element. The dose adjustment knob is rotatable with respect to said housing to set a desired injection dose. The lead screw includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that expelling medication from a cartridge. The actuator is rotatably fixed on said lead screw to prevent relative rotation therebetween, said actuator being rotatable in a first direction to rotate and advance said lead screw in said first direction. The recoil member is fixed with rotation on said actuator to prevent relative rotation between them. The pawl element is positioned between said dose setting knob and said recoil member, said pawl member comprising a first arm member engaging an inner surface of said dose setting knob, and a second arm member engaging an outer surface of said recoil member, wherein one of said first and second arms produces an audible signal when said dose adjustment knob is rotated with respect to said housing.
    [009] According to yet another exemplary embodiment of the present invention, a medication injection pen is provided comprising a housing, for housing a dose adjustment knob, a lead screw, an actuator and a member of recoil. The dose adjustment knob is rotatable with respect to said housing to set a desired injection dose. The lead screw includes a thread element by which it can be advanced in a first direction through a corresponding threaded engagement, said first direction being that which expels medication from a cartridge. The driver is rotationally fixed on said lead screw to prevent relative rotation therebetween, said drive being rotatable in a first direction to rotate and advance said lead screw in said first direction. The recoil member is fixed with rotation on said actuator to prevent relative rotation between them. The housing further comprises a flexible protrusion provided on a surface within said housing, and the dose adjustment knob further comprises a flexible flap element which engages said protrusion to produce an audible signal upon completion of injection of a adjusted dose.
    [010] Additional objects, advantages and salient features of exemplary embodiments of the invention will become apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the accompanying drawings, discloses exemplary embodiments of the invention. Brief description of the drawings
    [011] The above aspects and advantages and other examples of certain exemplary embodiments of the present invention will become more evident from the following description of certain exemplary embodiments thereof when taken in conjunction with the accompanying drawings, in which:
    [012] Figure 1 represents a medication injection pen according to an exemplary embodiment of the present invention,
    [013] Figures 2A and 2B represent unassembled and assembled cross-sectional views, respectively, of exemplary components provided in a medication injection pen according to a first exemplary embodiment of the present invention,
    [014] Figure 2C represents an unassembled view of a pen needle usable in the exemplary embodiments of the present invention,
    [015] Figures 3A and 3B represent views of a body provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [016] Figures 4A and 4B represent views of a dose adjustment knob provided on a medication injection pen according to the first exemplary embodiment of the present invention,
    [017] Figures 5A and 5B represent views of a recoil member provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [018] Figures 6A and 6B represent views of a tongue element provided in a medication injection pen according to the first exemplary modality of the present invention,
    [019] Figure 7 represents a view of an advance screw and actuator arrangement provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [020] Figures 8A and 8B represent views of a dose interrupt member provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [021] Figures 9A and 9B represent views of a lead screw brake provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [022] Figures 10A and 10B represent views of an alternative injection coupling mechanism provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [023] Figures 11A - 11F represent views of alternative modalities of threaded insertion and lead screw stop provided in a medication injection pen according to the first exemplary embodiment of the present invention,
    [024] Figures 12A - 12E represent views of an injection end latch mechanism in a medication injection pen according to the first exemplary embodiment of the present invention,
    [025] Figure 13 represents a view of a muted injection latch mechanism in a medication injection pen according to the first exemplary embodiment of the present invention,
    [026] Figures 14A and 14B represent views of an additional mechanism for reducing friction between components in a medication injection pen according to the first exemplary embodiment of the present invention,
    [027] Figures 15A and 15B represent exemplary mechanisms for connecting a cartridge to a medication injection pen according to the first exemplary embodiment of the present invention,
    [028] Figures 16A and 16B represent unassembled and assembled cross-sectional views, respectively, of exemplary components provided in a medication injection pen according to a second exemplary embodiment of the present invention,
    [029] Figure 17 represents a view of an advance screw and actuator arrangement provided in a medication injection pen according to the second exemplary embodiment of the present invention,
    [030] Figure 18 represents a view of a last dose control mechanism provided in a medication injection pen according to the second exemplary embodiment of the present invention,
    [031] Figures 19A and 19B represent views of alternative last dose control mechanisms provided in a medication injection pen according to the second exemplary embodiment of the present invention,
    [032] Figure 20 represents an assembled cross-sectional view of exemplary components provided in a medication injection pen according to a third exemplary embodiment of the present invention,
    [033] Figure 21 represents a view of a body provided in a medication injection pen according to the third exemplary embodiment of the present invention,
    [034] Figure 22 represents a view of an insert provided in a medication injection pen according to the third exemplary embodiment of the present invention,
    [035] Figure 23 represents a view of a trigger provided in a medication injection pen according to the third exemplary embodiment of the present invention,
    [036] Figure 24 represents a view of a dose adjustment knob provided on a medication injection pen according to the third exemplary embodiment of the present invention and
    [037] Figure 25 represents a view of a recoil member provided in a medication injection pen according to the third exemplary embodiment of the present invention.
    [038] Throughout the drawings, like reference numerals will be understood to refer to like elements, features and structures. Detailed description of exemplary modalities
    [039] The topics exemplified in this description are provided to aid in a comprehensive understanding of the exemplary embodiments of the present disclosure with reference to the figures in the accompanying drawing. Accordingly, those skilled in the art will recognize that various changes and modifications to the exemplary modalities described herein can be made without departing from the scope and spirit of the claimed invention. Also, well-known descriptions of functions and constructions are omitted for clarity and brevity.
    [040] With reference to the drawing figures, particularly figure 1, a medication injection pen is shown and generally indicated with the reference numeral 10. The medication injection pen 10 can be used for administering various medications, preferably liquid in nature, including but not limited to insulin and human growth hormones. The term “medication” is used in an illustrative and non-limiting manner to refer to any substance that can be injected into a patient for any purpose. The medication injection pen 10 is provided to administer multiple injections, the dose or volume of which can be adjusted by the user and may vary for each injection. Exemplary embodiments of the medication injection pen 10 of the present disclosure may be disposable or reusable when the medication supply therein has been depleted.
    [041] Referring to Figures 2A and 2B, in an exemplary embodiment, the medication injection pen 10 generally includes a cap 12, a cartridge holder 14, a rotor 16, a body 18, a dose knob 20, a recoil member 22, a drive member 24, a lead screw 26, a dose stop member 28, a bidirectional pawl member 30, a lead screw stop 32 and a push button 34.
    [042] Cartridge holder 14 is formed to accommodate a medication cartridge 36, which may be of any conventional design. By way of non-limiting example, cartridge 36 may include an elastomeric septum 38 at a distal end thereof, and an open proximal end 37 that exposes a sliding plunger 40. A medication is contained within cartridge 36 between septum 38 and the plunger 40. As will be described in more detail below, the rotor 16 is configured to engage the plunger 40 and force distal movement thereof to expel medication from the cartridge 36. The rotor 16 includes an opening formed for snapping or otherwise engaging a distal end bead portion 27 (figure 7) of lead screw 26 on rotor assembly 16 on lead screw 26. A standard pen needle 11 (figure 2C) is used to administer the dictation from the medication injection pen 10. The needle is a double-ended cannula 5 that is screw-mounted onto the threads 42 of the cartridge holder 14, as is well known in the art. One end of the cannula 5 is exposed for insertion into a patient, while the second end of the cannula is arranged to pierce the septum 38 of the cartridge 36. After administration of an adjusted dose, the needle 11 can be removed, in which case the septum 38 may be self-sealing. Cap 12 is formed for releasable mounting on cartridge holder 14, such as with a snap fit or other releasable engagement, to limit contamination of septum 38 and surrounding portions of cartridge holder 14. A resilient clamping arm 13 may extend from cap 12 to provide a clamping force to retain the injection pen 10 in the user's pocket, purse or carrying case. One or more windows 15 may also be provided on cartridge holder 14 to provide a visual indication of the volume of medication remaining in cartridge 36.
    [043] An exploded perspective view of a pen needle 11 of an exemplary injection pen is shown in Figure 2C. The pen needle 11 includes the cap (outer shield) 1, an internal shield 2, a needle cannula 5 and a hub 3. During manufacture, the proximal end of the needle cannula 5 is inserted into a central opening in the distal (patient) end 4 of hub 3 until a predetermined length of the distal (patient) end of needle cannula 5 remains extended. Needle cannula 5 is secured by epoxy or adhesive to distal end 4 of hub 3. To protect users from injury and needle cannula 5 from damage, inner shield 2 covers the exposed part of needle cannula 5 The open proximal end of the inner shield 2 is placed over the exposed portion of the needle cannula 5. The open proximal end of the bonnet 1 envelops the inner shield 2, needle cannula 5 and hub 3. The distal end of the bonnet 1 it is closed to prevent contamination and damage to the internal components of the pen needle 11 and to prevent injury to anyone who might handle it before use. When the user is ready to use the pen needle, hub 3 is threaded onto threads 42 of cartridge holder 14 of injection pen 10 (figures 1, 2A and 2B) and cover 1 and shield 2 are removed The hub 3/cannula 5 subassembly is interrupted by a pulling action. The distal end of the inner shield 2 is closed to protect the user from accidental needle sticking through the needle cannula 5 after the shield 1 is removed. Inner shield 2 is then removed to access needle cannula 5.
    [044] With reference to Figures 3A and 3B, the body 18 is generally cylindrical and includes a cylindrical wall or partition 50 extending through the interior of the body 18 through which a channel 51 is formed comprising an opening 52. The cylindrical wall 50 divides effectively the body 18 into two compartments, a first compartment proximal to the wall 50 to house the plurality of adjustment and dose injection components as shown in Figures 2A and 2B, and a second compartment distal to the wall 50 to house the brake of lead screw 32 and connect to cartridge holder 14. Channel 51 comprises internal threads 54 threadingly engaging corresponding threads of lead screw 26. In an exemplary embodiment, lead screw 26 is provided with a section. non-circular transverse, in which case the opening 52 is defined to allow rotational and thus axial movement of the lead screw 26 therethrough. A plurality of second threads 56 are provided within the body 18 in the first housing and threadedly engaged with corresponding threads 62 provided in the dose adjustment knob 20, as discussed further below. The body 18 preferably includes a window 57 enabling the user to see an adjusted dose indicated on the outer surface of the dose adjustment knob 20. As described further below, a series of inclined steps or teeth 55 is provided within the second compartment. of body 18, circumferentially encircling the distal end of channel 51. Teeth 55 are provided as part of a one-way coupling with lead screw 32 to allow lead screw 26 to rotate through channel 51 in only in one direction, which direction causes the lead screw to expel the medication from the cartridge 36. In an exemplary embodiment, the body 18 also includes a circumferential rib or groove 58 in which the cartridge holder 14 can be mounted with a snap fit. pressure.
    [045] Referring to Figures 4A and 4B, a generally cylindrical dose adjustment knob 20 with open proximal and distal ends is provided with an enlarged proximal portion or gripper 60 defining a handle-like appearance. The gripper 60 may include a plurality of slots 61 enabling a user to firmly grip the gripper 60 to set a dose of medication for an injection. The dose adjustment knob 20 includes at least one threaded element 62 provided on its outer surface, preferably near the distal end and threadingly engaging with corresponding threads 56 within the body 18. An injection dose is adjusted by the user by rotating the dose adjustment knob 20 in a predetermined direction. Due to threaded engagement with body 18, rotation of dose adjustment knob 20 translates in axial movement of dose adjustment knob in the proximal direction extending away from and away from body 18. Provided on the outer surface of body 18 is a plurality of dosage indicia (not shown) indicating an adjusted dose to be viewed through window 57 provided of body 18.
    [046] A plurality of radially directed edges 63 are provided circumferentially along the inner surface of the dose adjustment knob 20 adjacent to the gripper 60. The edges 63 provide part of a pawl mechanism in conjunction with an externally ratchet member directional 82 provided in pawl arm 81 (Figures 6A, 6B) of pawl member 30. The edges 63 each comprise a sloping edge and a flat face to allow relative rotational movement between the adjusting knob. dose 20 and pawl member 30 in only one direction in which pawl arm 81 can slide over edges 63, thus producing an audible and tactile signal. Additionally, the leading edges of the edges 63 define a proximally facing surface having a plurality of teeth 64 disposed thereon. In an exemplary embodiment, teeth 64 are included as part of an engaging mechanism when engaged with corresponding teeth 74 (Figures 5A and 5B) disposed on recoil member 22. When pressed together during injection, teeth 64 and 74 lock together, thereby preventing relative rotation between recoil member 22 and dose adjustment knob 20, as further described below. Additionally, during dose adjustment, teeth 64 provided on dose adjustment knob 20 function as a platform, causing axial movement of recoil member 74 together with dose adjustment knob 20, when the adjustment knob The dose adjustment knob 20 also includes a plurality of longitudinally extending keys or slots 65 provided substantially along the interior surface, preferably extending from the open distal end to the portion. flared proximal 60. The longitudinal slots 65 engage with corresponding slots 95 provided on the outside of the dose interrupt member 28 to prevent relative rotation between the dose adjustment knob 20 and the dose interrupt member 28, but to allow the relative axial movement between them.
    [047] The recoil member 22 comprises an elongated generally cylindrical member as shown in Figures 5A and 5B. Provided near the proximal end of setback member 22 is a plurality of ridges 73 spaced along its outer surface. When the exemplary injection pen 10 is assembled, edges 73 of recoil member 22 turn to edges 63 provided on the inner surface of dose adjustment knob 20. Edges 73 include slanted edges and flat faces for engaging with a internally directed ratchet member 84 provided on flexible arm 83 of pawl member 30. As similarly described above, edges 73 enable relative rotational movement between recoil member 22 and pawl member 30 in only one direction in the which the inwardly directed ratchet member 84 can slide over the edges 73 producing an audible and tactile signal. The permitted direction of relative rotation between recoil member 22 and pawl member 30 is in the opposite direction to that enabled by similar engagement between dose adjustment knob 20 and pawl member 30, so that relative rotation between dose adjustment knob 20 and recoil member 22 are bidirectional.
    [048] The tongue element 30 is described with reference to figures 6A and 6B. As shown, the pawl member 30 is a cylindrical tube-like member comprising a plurality of radially flexible arms 81 and 83 oppositely disposed one another. Tongue member 30 is preferably constructed with a longitudinal dimension similar to the length of edge portions 63, 73 provided on dose adjustment knob 20 and recoil member 22, respectively. Flexible arm 81 includes an externally directed ratchet member 82 provided at its free end facing ridges 63 provided within the dose adjustment knob 20. Flexible arm 83, on the other hand, includes an internally directed ratchet member 84 provided at its free end facing ridges 73 provided outside the recoil member 22. During dose adjustment, the pawl member 30 is allowed to rotate relative to both the recoil member 22 and the knob. dose adjustment 20, but in only one direction with respect to each. In other words, during dose adjustment, the pawl member 30 is rotationally locked in one between the recoil member 22 or the dose adjustment knob 20 via flexible arms 83 and 81, respectively, depending on the direction. of relative rotation for any normal adjustment of a dose or backflow measurement of the adjusted dose. When the dose adjustment knob 20 is rotated in the direction in which the edges 63 can slide over the externally directed ratchet member 82 and produce an audible signal, the pawl member 30 does not move with rotation relative to the recoil member. 22, since such movement is prevented by an engagement between the pawl arm 83 and the edges 73. Conversely, when the dose adjustment knob 20 is rotated in the opposite direction, the externally directed ratchet member 82 engages with one of the edges 63 causing the pawl member to rotate together with the dose adjustment knob 20. In that case, the inwardly directed ratchet member 84 can now slide past the edges 73 on the recoil member, thereby producing an audible signal.
    [049] The exemplary construction of the pawl element 30 described above allows for relative rotation in both directions between the recoil member 22 and the dose adjustment knob 20. Such a pawl element is not restricted to the design represented in the figures 6A and 6B. Any similar members enabling birotational movement between the recoil member 22 and the dose adjustment knob 20, as described above, can be performed in this embodiment, as would be evident to one skilled in the art.
    [050] As shown in Figure 5A, the recoil member 22 includes an adapter element 71 for pressure adjustment with an internal cavity of the pushbutton 34. The pushbutton 34 is of any conventional design, but it is preferred that the snap-in engagement enables the push-button to rotate freely on the adapter element 71. Alternatively, the push-button 34 may be formed unitarily with the adapter element 71. Additionally, as shown in Figure 5B, a plurality of longitudinally extending keys or slots 75 is provided along the inner cylindrical surface of recoil member 22. Slots 75 are formed to engage corresponding longitudinal slots 85 provided in the outer surface of drive member 24 shown in Figure 7, thus preventing relative rotation between the member. recoil 22 and actuator 24, while allowing relative axial movement between them. Referring to Figure 7, the driver 24 includes proximal and distal open ends that produce a passage 86 for the lead screw 26. In an exemplary embodiment, the passage 86 comprises a non-circular cross section corresponding with the non-circular cross section. of the lead screw 26, thus preventing relative rotation between them. Actuator 24 includes a disk 87 formed at the proximal end for pressure engagement with at least one flexible tab 97 provided on the inner surface of dose stopping member 28 (Fig. 8A). With the pressure engagement, the actuator 24 is axially fixed with respect to the dose stopping member 28, but is capable of rotation with respect thereto. The actuator 24 may also include one or more inwardly oriented flexible legs 88 to engage the lead screw 26. The flexible leg 88 may be provided to reduce any clearance between the corresponding cross sections of the lead screw 26 and the opening 86 to improve the dose accuracy of the exemplary 10 injection pen.
    [051] Referring to Figures 8A and 8B, a generally cylindrical dose stopping member 28 is provided to enable control of the last dose so that a dose cannot be adjusted or measured that is greater than the amount of medication remaining in cartridge 36, as further discussed below. The dose stopping member 28 includes a plurality of longitudinal grooves 95 on its outer surface. The slots 95 engage with corresponding slots 65 provided within the dose adjustment knob 20, thereby preventing relative rotation between them, but allowing relative axial movement. The dose interrupt member 28 has an open proximal end 91 and an open distal end 92, the distal end 92 preferably comprising a reduced diameter section. The open distal end 92 defines a threaded opening with threads 93 disposed therein for threaded engagement with corresponding threads 25 of lead screw 26 when assembled. The proximal end 91 defines a cavity housing the recoil member 22, the driver 24 and the advance screw 26. Flexible tabs 97 are provided adjacent the open distal end 92, extending into the dose interrupt member 28 A recess 96 or cutout is provided in the cylindrical outer wall of the dose stopping member defining an area in which the flexible tabs 97 can flex. During assembly, the driver 24 is inserted into the open proximal end 91, whereby the disc 87 disposed near the distal end of the driver 24 engages the flexible tabs 97 and causes them to flex outwardly into the recess 96 until the disc 87 moves past the flexible tabs, at which time the flexible tabs 97 return to their initial positions to provide a locking surface for the actuator 24, preventing relative axial movement between them.
    [052] Although the above components are described as comprising specific aspects for engaging and interconnecting other components of an exemplary injection pen, the above components are not limited to these specific aspects. For example, instead of the corresponding non-circular cross sections described to prevent relative rotation between lead screw 26 and driver 24, one skilled in the art will find that similar functionality can be provided using a slot/slot engagement to prevent relative rotation between them while also allowing for relative axial movement. Conversely, the above-described slot/groove aspects may be replaced by corresponding non-circular arrangements or other known features to prevent relative rotation while allowing relative axial movement therebetween.
    [053] With reference to figures 9A and 9B, lead screw brake 32 comprises a generally cylindrical housing portion 90 provided with a first diameter large enough to surround channel 51, as shown in figure 9B. Extended in the distal direction, a pair of wall portions 92 are provided defining an opening 93 with a non-circular cross section to match the non-circular cross section of lead screw 26. Due to the corresponding non-circular opening 93, the lead screw lead 26 is prevented from rotating with respect to lead screw brake. In addition, lead screw brake 32 comprises a pair of flexible ratchet arms 94 configured to engage the cylindrical ring of ratchet teeth 55 provided within body 18 to define a unidirectional coupling therebetween. The ratchet arms 94 are configured to allow rotation of the lead screw 32 and therefore lead screw 26 brake in only one direction with respect to the body 18. The allowable direction is that which makes the screw advance lever 26 rotate through threaded channel 51 in the distal direction to expel medication. During injection, lead screw brake 32 rotates relative to body 18 and ratchet arms 94 extend over the slanted or ramped portion of teeth 55 to produce an audible click signal indicating that injection is being performed. Rotation of the lead screw brake in the opposite direction causes the free ends of the ratchet arms 94 to engage the flat faces of teeth 55, which resist engagement of the ratchets of the ratchet arms 94 and thereby prevent relative rotation in that direction. Due to the unidirectional coupling between lead screw stop 32 and teeth 55, an unwanted backward movement of lead screw 26 is prevented.
    [054] Having described exemplary structures, aspects and mutual relationships between particular members of the exemplary embodiment of the medication injection pen 10 here, the intended functionality of such an exemplary medical pen device will now be described.
    [055] Following assembly of the exemplary limbs as shown in figures 2A, 2B and as described above, to set a desired dose, the patient or user first holds and rotates the flared proximal end 60 of the dose adjustment knob 20. The knob dose setting dial 20 is rotated in several rotations relative to body 18 until a desired dose is shown through window 57 in body 18. Due to threaded engagement of thread 62 on dose setting knob 20 with internal thread 56 from the body, the dose adjustment knob is induced to unscrew from the proximal end of the body, carrying the recoil member 22 along with it for substantially the same distance. The dose stop member 28 is also induced to rotate together with the dose adjustment knob 20 due to the slot/slot engagement between the slot 65 provided within the dose adjustment knob 20 and the slot 95 provided on the outside of the dose stopping member 28. Rotation of the dose stopping member 28 causes axial movement of the dose stopping member with respect to the body 18 in the proximal direction due to the threaded engagement between the threads 93 on the dose stopping member and the threads 25 of lead screw 26. Dose stop member 28, however, moves axially shorter distance than dose adjustment knob 20, due to a difference in pitch of thread 25 of lead screw 26 and the internal thread 56 of the body 18.
    [056] During normal dose adjustment to increase an adjusted dose, lead screw 26 is prevented from rotating with respect to body 18 in the dose adjustment direction, due to unidirectional coupling between lead screw 32 brake and the teeth 55 arranged in body 18. Retract member 22 and driver 24, which are rotatably fixed to each other due to slot/slot connection 75/85, therefore, are also prevented from rotating with respect to body 18 du during dose adjustment, provided that the actuator is fixed with rotation on the lead screw through the union of the non-circular cross section of the lead screw 26 and the non-circular opening 86 of the trigger 24. Due to such pressure adjustment between the disk 87 of the actuator 24 and the flexible tabs 97 provided on the dose stopping member 28, when the dose stopping member unscrews from the body in the proximal direction, the actuator 24 moves axially the same distance but does not rotate.
    [057] The recoil member 22 is interlocked to the dose adjustment knob 20 via the bidirectional pawl element 30. During normal dose adjustment, the dose adjustment knob 20 rotates relative to the pawl element 30 and thus a audible signal is produced due to the sliding of the internal grooves 63 of the dose adjustment knob 20 past the externally directed ratchet member 82 on the flexible arm 81. The externally directed ratchet member 82 tends to slide past the edges 63 in the direction of adjustment of dose because the internally directed ratchet member 84 of the flexible arm 83 is locked with the ridges 73 provided on the recoil member 22, which is prevented from rotating in that direction due to its engagement with the driver 24 and the lead screw 26.
    [058] If the user initially sets a dose greater than desired, the set dose can be “rolled back” or reduced simply by rotating dose setting knob 20 in the opposite direction. Rotation of dose adjustment knob 20 in this reverse direction, which is the injection direction, would normally cause lead screw 26 to rotate and thus axial movement of lead screw into cartridge 36. During injection, rotation of the lead screw 26 is effected due to the coupling between the teeth 64 on the dose setting knob and the teeth 74 on the setback member 22, which is indirectly fixed with rotation on the lead screw 26. During reflow, however, dose adjustment knob 20 and recoil member 22 are not engaged via teeth 64/74 and dose adjustment knob 20 rotates in that inverse direction relative to recoil member 22 via pawl member 30. Reverse rotation of the dose adjustment knob 20, during measurement reflow, now causes the internal edges 63 to engage and lock onto the dose adjustment knob 20 with the externally directed ratchet member 82, forcing the pawl member 30 to rotate therein. same direction. The inwardly directed ratchet member 84 is now induced to slide over the edges 63 provided on the recoil member 22, thereby producing an audible signal indicating that the dose is being reduced. Ratchet member 84 tends to slide over edges 73 in that direction since there is less friction produced between ratchet member 84 and edges 73 than there is between unidirectional coupling between lead screw brake 32 and body 18 In other words, the force required to cause backflow of a set dose measurement is not great enough to overcome the friction between the brake ratchet arms 94 of the lead screw 32 and the teeth 55 of the body 18.
    [059] After a desired dose is adjusted, and the user wants to inject the adjusted dose of medication, the medical injection pen 10 is applied to the patient's skin to insert the needle cannula 5. The needle of the pen 11 is attached to the threaded portion 42 of cartridge holder 14 before or after setting the desired dosage, as a matter of user preference. After the pen needle 11 has been secured in the cartridge holder 14 and inserted into the patient, the push button 34 is lowered. Axial force applied to push button 34 by the user causes teeth 74 on recoil member 22 to engage with teeth 64 on dose adjustment knob 20 to pivotally engage and lock recoil member 22 with the adjustment knob. dose 20, forming an injection coupling. The applied force causes dose adjustment knob 20 (due to a non-self-locking threaded engagement with body 18 via threads 56 and 62) to rotate in the opposite direction to that which occurs during normal dose adjustment. This rotation is now granted to recoil member 22 and therefore driver 24 (due to slot/slot connection 75, 85). Since the driver 24 joins with the non-circular cross section of the lead screw 26, the lead screw is also induced to rotate relative to the body 19, which translates in axial movement of the lead screw into the cartridge 36 to expel a dose (due to the threaded engagement between the threads 25 in the lead screw and the threads 54 disposed in the channel 51 of the body 18). Axial movement of the lead screw in the distal direction urges the rotor 16 against the plunger 40 to expel the medication from the cartridge 32. The injection force is greater than the frictional force on the lead screw 32 brake and, therefore, the lead screw brake allows rotation of the lead screw 26 in that direction during injection. As lead screw brake 32 rotates with lead screw 26, oppositely arranged ratchet arms 94 slide over teeth 55 disposed within body 18 to produce a clicking sound as injection is performed.
    [060] The dose administration process described above may be repeated until the medication in cartridge 36 has run out. Before expelling the last dose from cartridge 36, it is desired to ensure that the last expelled dose is consistent with the dose set by the user. In other words, the user should not be able to adjust a dose to an amount greater than the remaining volume of medication in cartridge 36. This last dose control is performed when the threads 93 disposed on the dose stop member 28 touch against an unthreaded portion of lead screw 26 at its proximal end, preventing further rotation of dose stopping member 28 on lead screw 26. When this occurs, the indicia on dose adjustment knob 20, read through window 57, indicate the last remaining injectable volume of medication in cartridge 36. After dose stopping member 28 is prevented from rotating further, dose adjustment knob 20 is also prevented from rotating further in that direction to adjust a larger dose, due to the 65/95 slot/slot engagement between the dose adjustment knob 20 and the dose stop member 28.
    [061] During dose adjustment, the dose stop member 28 changes its relative position on the lead screw 26 based on the number of rotations of the dose adjustment knob 20. The axial movement of the dose stop member 28 during the dose setting is by substantially the same distance that the lead screw 26 moves into the cartridge 36 during injection. The length of axial movement of the lead screw 26, and therefore the volume of medication to be expelled, is determined in part by the thread pitch of the lead screw threads 25 and body threads 54, which is substantially the same as the pitch of the threads 93 on the dose stopping member 28. Thus, the relative position of the dose stopping member 28 on the lead screw 26 throughout the administration is indicative of the amount of dosage remaining in the cartridge 36. dose maintains its relative position on lead screw 26 during injection due to its 65/95 slot/slot engagement with dose adjustment knob 20. During injection, dose adjustment knob 20, the stop member 20 dose 28, recoil member 22, driver 24 and lead screw 26 are all locked together with rotation. Since the threads 93 of the dose interrupt member 28 and the threads 54 of the body 18 are of substantially the same pitch, simultaneous rotation of the dose interrupt member 28 and lead screw 26 results in the same axial movement. Thus, during injection, the dose stopping member 28 does not move axially with respect to the lead screw 26 and therefore maintain its relative position with respect to the lead screw as determined during the dose adjustment procedure. After administration of the last dose, if the injection pen 10 is reusable, the cartridge can be replaced, whereas, if the pen is disposable, the entire pen 10 can be discarded.
    [062] As will be appreciated by those skilled in the art, various modifications can be made in the above exemplary embodiments without substantially altering the functionality of the injection pen 10. For example, such modifications can be made to facilitate the assembly of the various components , reduce manufacturing complexity, reduce the number of members, or provide some additional improved functionality. Some such exemplary modifications are described below.
    [063] In an alternative embodiment, teeth 64 on dose adjustment knob 20, described above as part of an injection coupling with corresponding teeth 74 (figures 5A and 5B) disposed on recoil member 22, can generate signals of dose adjustment click in the absence of pawl member 30. A spring member or wave washer with similar functionality may be provided to guide teeth 74 of recoil member 22 toward corresponding teeth 64 provided in the adjustment knob. dose 20, so they are in constant engagement. The spring force, however, is easily overcome by the relative rotation between the dose adjustment knob 20 and the recoil member 22, which causes the corresponding teeth 64/74 to slide over each other producing an audible and tactile signal. .
    [064] In another exemplary embodiment, an alternate injection coupling is provided between a modified dose adjustment knob 20 (teeth 64 removed) and a modified recoil member 22', shown in Figure 10. In this embodiment, the injection coupling described above with respect to teeth 64 on dose setting knob 20 and corresponding teeth 74 on setback member 22, is replaced by an extended surface 101 provided near the proximal end of setback member 22', the extended surface 101 being defined by a larger diameter with respect to edges 73. Tongue element 30 includes a first surface 102 positioned coaxially on and surrounding extended surface 101. During the dose adjustment operation, tongue element 30 is positioned on the tongue member. setback 22', such that pawl arms 81 and 83 are free to flex and slide past edges 73 and 63, respectively. In this mode, the metering dose and reflow adjustment mechanism is unchanged. During injection, however, with the user applying an injection force to push the button 34, the recoil member 22' is pushed into the dose adjustment knob 20 and into the pawl member 30. When the member of recoil 22' moves axially to the pawl member 30, the extended surface 101 is moved into engagement with the pawl arm 83, as shown in Fig. 10B. In this position, pawl arm 83 cannot flex radially inwardly to slide past slots 63 in the dose adjustment knob, thus locking pawl member 30 into dose adjustment knob 20. The relative rotation of the dose adjustment knob dose 20 with respect to recoil member 22' in this direction during dose adjustment would enable the passage of the ratchet arm 83 over the edges 63 to reduce an adjusted dose. During injection, however, the ratchet arm 83 is now prevented from flexing away from the edges 63 and thus prevented from sliding over the edges 63, by the locking engagement of the extended surface 101. In this way, the recoil member 22' is now rotationally locked in dose adjustment knob 20 through non-slip engagement with the ratchet arm 83, thus enabling injection of an adjusted dose as described above.
    [065] In another embodiment, the exemplary injection pen 10 is modified to facilitate the manufacture of injection pens providing different dosing needs. For example, an injection pen for administering a first medication may need finer dosing intervals for more accurate dosing control than that of another medication. In order to utilize the same exemplary injection pen dose adjustment and injection functionality described above, it is desired to be able to provide a plurality of pens satisfying various dosing needs with greater compatibility, so as to reduce the complexity of manufacturing multiple such pens.
    [066] Such modification is made in the modality illustrated in Figure 9B to alternate the ratchet arms 94 provided in the lead screw brake 32 with the ratchet teeth 55 provided in the body 18, as shown in Figure 11A. As shown, body 18' now includes ratchet arms 111 and lead screw brake 32' now includes teeth 112. Engagement between ratchet arms 111 and teeth 112 serves to provide similar unidirectional functionality as described in previous modality. The 32’ lead screw brake in this alternative mode facilitates a change in the desired injection click interval required for a desired change in a dosing interval. For example, the injection clicks performed by the relative rotation of the lead screw 32' brake preferably correspond with a dose increment, and are related to the spacing of teeth 112. If the dose increment is changed to have an inter greater or lesser value, the lead screw brake with a spacing of corresponding teeth 112 is mounted on the injection pen as shown, as opposed to providing a new body 18 with the desired spacing of teeth 55, as in the previous embodiment. The smaller lead screw brake 32 is easier and cheaper to manufacture than the body 18 and therefore it is advantageous to replace the lead screw 32 brake in the modified injection pen as opposed to replacing the body 18.
    [067] An additional modification, shown in figures 11B-11F, allows for easier change of lead screw thread pitch if desired to increase or decrease dose rate. For example, the threads 25 of the lead screw 26 can be modified to include a larger pitch so that the same number of lead screw rotations results in greater axial movement of the lead screw into the cartridge 36 and, therefore, a larger dose volume. In the previous embodiment, if the threads 25 of the lead screw 26 are modified, the threads 54 of the body are also modified accordingly. The additional modification shown in Figure 11B provides an insert 114 that replaces aspects of the partition wall 50 and channel 51 with threads 54 disposed therein in the exemplary embodiment (see Figure 3A). Insert 114 is a nut-like member with ratchet arms 115 disposed therein. Insert 114 comprises a wall 118 with an opening 119 therethrough. Aperture 119 is defined by a cylindrical channel 116 with threads 117 disposed therein. Body 18" now includes a platform or edge 121 forming a contact surface engaging with a proximal surface of insert 114 to determine axial placement of insert 114 on body 18". Platform 121 comprises at least one protrusion member 122 configured to engage a corresponding recess 120 in the proximal face of insert 114. Engagement between protrusion 122 and recess 120 prohibits relative rotational movement between insert 114 and body 18". Alternatively, any similar keyway/groove type structure may be provided to limit relative rotational movement between insert 114 and body 18”.
    [068] The insert 114 may also be provided with an additional molded spring appearance 124 to maintain the positioning of the insert 114 against the platform 121 in the 18” body. The molded spring feature 124 also presses against the cartridge 36, as shown in Figure 11F, to prevent the cartridge from moving when the needle 5 is inserted into the cartridge septum 38 prior to injection. This aspect provides greater precision in the injection of the dose and prevents unwanted wastage of medication. In prior art injection pens, the cartridge may move a short distance in the proximal direction during this operation, resulting in little waste or “run-off” of the medication.
    [069] In another exemplary embodiment, the end of click or injection signal is produced by a modified 20' dose adjustment knob including a radially flexible leg 128 near the distal end of the 20' dose adjustment knob extended in the direction distal. Flexible leg 128 interacts with an inclined protrusion 130, shown in Figure 12B, disposed on a proximal surface of the partition wall 50 of the body 18. The inclined protrusion 130 is preferably secured to the partition wall 50 at only one end, which is the far end of the inner surface of the body 18. In a zero dose position, when the dose adjustment knob 20' touches the split wall 50, the flexible leg 128 is positioned close to the protrusion 130, but not in touch engagement. With the setting of a desired dose, when the dose setting knob 20' is rotated, the flexible leg 128 moves between the slanted protrusion 130 and the inner surface of the body 18, as shown in Figure 12C. Since the slanted bulge 130 is not secured to the dividing wall 50 at the end closest to the inner surface of the body 18, the slanted bulge flexes radially to allow the flexible leg to pass through and reduce friction to initially overcome the bulge during dose adjustment. After flexible leg 128 passes behind protrusion 130, continuous rotation of dose adjustment knob 20' will result in axial movement of dose adjustment knob away from dividing wall 50 such that flexible leg 128 will not. interacts more with the lump 130. Normal dose adjustment is now performed.
    [070] As the adjusted dose is injected, the dose adjustment knob 20' screws back into the body 18 and moves to the split wall 50. When the injection is near its end, the flexible leg 128 again engages protrusion 130, as shown in Figure 12E. At that time, when flexible leg 128 touches against protrusion 130, it cannot pass between protrusion 130 and the inner surface of body 18. Now flexible leg 128 is induced to flex radially inward to slide past protrusion 130 until it moves past the end of the protrusion 130, at which time the flexible leg 128 presses against the inner surface of the body 18 producing an audible and tactile signal. At this point, the set dose is fully delivered and the injection pen is in a zero dose position.
    [071] In one embodiment, the end of dose click may be provided as a distinct signal distinguishable from the injection clicks provided by the lead screw brake 32, as discussed above with respect to Figure 9. In another embodiment, however, injection clicks are muted and the user feels only the end of the injection click provided between the flexible leg 128 and the protrusion 130. One way to mute the injection clicks is to replace the ratchet teeth 55 provided on the body 18 with a rubber-like ring or brake 134, as shown in figure 13. During injection, lead screw brake 32 still rotates relative to body 18, but in this mode, ratchet arms 94 slide to the along the surface of the rubber brake 134 without producing an audible or tactile signal. The rubber brake 134 is fixed to the body 18 using an adhesive or other structure so that it does not rotate relative to the body 18 and is therefore still capable of functioning as a unidirectional coupling with the lead screw brake 32 The arms of the ratchet 94 of the lead screw brake 32 are preferably chamfered or otherwise configured to hold the rubber brake shaft 134 to prevent relative rotation therebetween, similar to the embodiment discussed in Figure 9B. Additionally, one skilled in the art will find that the rubber brake 134 can be modified as similarly discussed in Figures 11A and 11B.
    [072] In another exemplary embodiment, an element or elements are added to improve the mechanical efficiency of an exemplary 10 injection pen, by eliminating or reducing friction between elements that rotate relative to one another or those that move axially with respect to each other. A particular engagement with undesirable friction is between the push button 34 and the adapter element 71 provided on the recoil member. During dose setting and injection, push-button 34 preferably rotates freely on adapter element 71. In an exemplary embodiment, as partially shown in Figure 5A, adapter element 71 includes a point 77 provided at the center of the geometric axis of rotation. of recoil member 22. This point 77 contacts push-button 34 near its center of rotation. Providing such a contact surface between these members at or near the center of rotation reduces the friction torque between these members during relative rotation and thereby increases efficiency. To further reduce friction between recoil member 22 and push-button 34, one embodiment includes at least one roller ball (i.e., ball bearing) 140 located between an inner surface of push-button 34 and a surface of the adapter element 71 as shown in Fig. 14A. Bearing balls 140 function to translate sliding friction between the engagement members into reduced bearing friction. In another embodiment, shown in Figure 14B, a pair of magnets 142a and 142b with the same polarity are provided on adjacent contact surfaces facing each other. For example, a first magnet 142a is provided within the push button 34, while the second magnet 142b is provided on a contact surface of the adapter element 71 facing the first magnet. Due to the same polarity between magnets 142a and 142b, the resulting repulsion force reduces the contact force between these two surfaces, thus reducing friction between them without affecting the thrust force required to inject the medication. One skilled in the art will appreciate that the above methods can also be performed in combination. Furthermore, such methods can be performed between any two components with a linear or rotational contact surface, to further improve mechanical efficiency.
    [073] The exemplary modalities described above can be supplied as a reusable or disposable pen. In a disposable implementation, cartridge holder 14 and body 18 are preferably irreversibly mounted. In one embodiment, as described with respect to Figure 3A, a circumferential rib provided in cartridge holder 14 presses into engagement with a slot 58 in body 18. In another embodiment, shown in Figure 15A, threaded insert 114 may include at least one snap-fit tab 125 with a recess 126 provided in the cartridge holder 114. Since the threaded insert 114, as discussed in connection with Figures 11B and 11C, is secured both axially and rotationally to the body 18, snap engagement of cartridge holder 14 on threaded insert 114 prevents relative rotation between cartridge holder and body.
    [074] In a preferred embodiment shown in Figure 15B, the cartridge holder 14 and the body 18 comprise a set of threads 151 and 152 that provide a secure threaded coupling between the cartridge holder 14 and the body 18. Additionally, a one of the cartridge holder and body comprises a lock 154 and the other comprises a recess 156 for engaging the lock 154. The lock/recess engagement is preferably a one-way radial lock. Thus, after body 18 and cartridge holder 14 are screwed together, latch 154 moves into engagement with recess 156 until they close together producing a secure, irreversible connection with minimal or no clearance between cartridge holder 14 and body 18, thereby increasing dose injection accuracy and reducing/eliminating unnecessary medication waste.
    [075] In view of the above description, another exemplary embodiment comprising similar components and functionalities is shown in figures 16A and 16B. The components shown in Figures 16A and 16B have functionality similar to those described above, unless otherwise noted, and therefore their detailed description is omitted here. In this embodiment, the body 218 is similar to the 18" body shown in figures 11B and 11D. A first compartment defined by the interior of the body 218, proximal to the wall 250, houses a dose adjustment knob 220, a recoil member 222, a dose stop member 228, a driver 224 and a lead screw 226. second compartment defined by the interior of body 218, distal to wall 250, houses a threaded driver insert 233 and a distal end 225 of driver 224. Wall 250 is provided with an aperture sized to fit the main cylindrical body of driver 224, but not the flared distal end 225, as shown in Figure 16B, thus axially securing the driver 224 to the body 218.
    [076] In this embodiment, lead screw 226 has a circular cross section and is pivotally secured to driver 224 via a keyway/slot engagement as shown in Figure 17. A proximal end of lead screw 226 includes keys. 217 engaging in longitudinal slots 223 provided within driver 224. Through this keyway/groove engagement, lead screw 226 is rotationally secured in driver 224 but can move axially relative to it. Actuator 224 comprises longitudinal slots 285 engaging internal keyways or slots 275 provided within recoil member 222 for rotationally locking actuator 224 therein. Actuator 224 now includes an flared distal end 225 provided with a ring of teeth 255 disposed on the circumference thereof and functioning similarly to the lead screw stop 32' in Figures 11A and 11B. Distal end 225 comprises part of a unidirectional coupling together with threaded insert 233, as similarly discussed above with respect to Figures 9B and 11B. Threaded insert 233 comprises an opening with threads disposed therein, which are threadedly coupled to corresponding threads in lead screw 226, similar to insert 114 of Fig. 11C.
    [077] In this embodiment, last dose control is provided by a modified dose stop member 228, as shown in Figure 18. The dose stop member 228 comprises a ring-like structure provided with a series of threads 290 disposed on its outer surface and threadedly engaged with threads 291 disposed on the dose adjustment knob 220. The dose stop member 228 is pivotally secured to the recoil member 222 through corresponding edges 272 provided on the inner surface of the dose stop member 228, which mesh with similar edges 273 disposed on the recoil member as shown. In this embodiment, as dose adjustment knob 220 is rotated to adjust a desired dose or decrease a very large dose, dose stopping member 228 screws onto threads 291 disposed on the dose adjustment knob by an amount related to the dose adjusted. During injection, the dose stopping member 228 maintains its relative position with respect to the threads 291 since the recoil member 228 is pivotally secured to the dose setting knob 220. Therefore, the dose stopping member 228 and dose adjustment knob 220 rotate together and there is no relative movement between them. After the dose stopping member 228 screws onto the threads at the end of the threads 291 it is prevented from further rotation and thus further rotation of the dose adjustment knob to set a larger dose is also prevented. Such an occurrence indicates a final dose of medication remaining in the cartridge.
    [078] To adjust a desired dose for injection, the user rotates the dose adjustment knob 220. The audible click of the adjusted dose is provided by sliding teeth 264 on the dose adjustment knob 220 with teeth 274 on the recoil member 222, as similarly described in the previous embodiment above. Teeth 264 and 274 are held in engagement by a spring member 233 provided within pushbutton 234. Similar to the previous embodiment, when the user presses pushbutton 234 to inject a dose, recoil member 222 is rotationally locked in dose adjustment knob 220 via engagement between teeth 264 and 274. Retract member 222 now rotates with dose adjustment knob 220 when dose adjustment knob screws back into body 218. Rotation of recoil member 222 translates to driver 224 which rotates lead screw 226. Lead screw 224 rotates through fixed threaded driver insert 233 and into the cartridge to expel a dose. When driver 225 rotates in that direction, the distal ring of teeth 255 provides the injection click as teeth 255 slide past the ratchet arms disposed on the threaded driver insert 233.
    [079] In another embodiment, last dose control is similarly provided with a modified 328 dose interrupt member as shown in Figure 19A. The dose stop member 328 is a half-nut-like member with a series of threads disposed on its inner surface, threadingly engaging the threads 332 provided in the threaded recoil member 322. The dose adjustment knob 320 comprises two longitudinally extending ribs or slots 330, spaced apart on the circumference by a distance substantially the same as the length of dose interrupt member 328. Slots 330 engage corresponding edges of dose interrupt member 328 to lock with rotation of the dose stopping member on the dose adjustment knob 320. During dose adjustment, the dose stopping member 328 screws onto the threads 332 of the recoil member 322, its relative position indicating the remaining volume of medication in the cartridge. When the dose interrupt member 328 reaches the end of a thread 332 or an interruption fixed to the dose adjustment knob 320 or the recoil member 322, the dose interrupt member 328 is prevented from rotating further and thus limits the dose to that remaining in the cartridge.
    [080] Yet another modality, using a similar principle of operation, is shown in figure 19B. In this embodiment, dose stopping member 428 is threaded along its outer surface with threads 427. The inner surface of dose adjustment knob 420 is provided with at least one thread disposed therein of sufficient length to maintain the constant engagement with the threads 427 of the dose interrupt member 428. The recoil member 422 comprises two longitudinally extending ribs or slots 430, spaced from each other on the circumference by a distance substantially the same as the length of the interrupt member 428. The slots 430 engage corresponding edges of the dose stopping member 428 to rotationally lock the dose stopping member to the recoil member 422. The outer surface of the recoil member 422 in this embodiment is provided with a substantially surface. smooth to allow axial movement of the dose interrupting member 428 therein. In this embodiment, the volume of the last dose is that indicated when the dose stopping member 428 is prevented from moving more axially relative to the recoil member 422. Axial movement of the dose stopping member 428 is prevented when a first edge of member 428 touches a fixed stop on dose adjustment knob 420 or recoil member 422.
    [081] In view of the above description, yet another exemplary embodiment of an injection pen comprising similar functionality is shown in Figure 20. As shown in cutaway view, an exemplary injection pen in this embodiment comprises a main body 518, a button a dose adjustment member 520, a recoil member 522, a drive 524, a lead screw 526, a dose stop member 528, and an insert 530. The body 518 is modified as shown in Figure 21. As shown, at least one ratchet arm 555, secured at one end of a side wall of the body 18 distal to the partition wall 550, is internally directed and preferably provided with a series of ridges or teeth 557 at its free end. Teeth 557 engage with teeth 595 disposed on the outer surface of insert 530, as shown in Figure 22. Teeth 557 are forced into engagement with teeth 595 on insert 530 when a cartridge holder is secured to body 18, due to the holder of the cartridge engaging the protrusion 559 provided on the outer surface of the ratchet arm 555. When the cartridge holder is secured to the body 518, the insert 530 is prevented from rotating in any direction due to the forced tooth engagement. When the cartridge holder is removed, such as to reuse the injection pen, the ratchet arms 555 are free to engage and allow relative rotation between the insert 530 and the body 518, to reload the lead screw for use. subsequent injection pen. Insert 530 comprises an opening 531 with a non-circular cross section to match a similar non-circular cross section of the lead screw to prevent relative rotation therebetween. A plurality of teeth 556 are provided circumferentially along an inner surface of body 518 proximal to dividing wall 550. Teeth 556 serve to engage a ratchet member 586 provided near the distal end of actuator 524, as shown in the figure. 23, described further below.
    [082] As shown in Figure 23, the actuator 524 comprises an elongated cylindrical member with distal and proximal open ends to allow the lead screw 526 to pass therethrough. Actuator 524 includes a plurality of slots 583 produced near the proximal end to engage corresponding slots within recoil member 522 to pivotally engage actuator 524 and recoil member 522 together. A pair of protrusions 585 is provided near the distal end of actuator 524 to press-in engagement with body 518 behind partition wall 550. This press-in engagement prohibits relative axial movement between actuator 524 and body 518 while allowing movement rotational relative between them. Actuator 524 includes at least one thread element 582 provided on the interior surface for threading engagement with a corresponding thread of lead screw 526. As discussed further below, it is this thread engagement that forces lead screw 526 to move. axially in the distal direction to inject an adjusted dose.
    [083] As shown in Figure 24, the dose adjustment knob 520 is an elongated cylindrical member provided with an external thread 562 threadingly engaging an internal thread of the dose adjustment knob, similar to the arrangements above. In this embodiment, dose adjustment knob 520 comprises at least one ratchet arm 564 provided near its distal end for engaging a plurality of ridges 573 provided on the outer surface of recoil member 522, as shown in Figure 25. Ratchet arm 564 includes a rounded protrusion 565 to enable sliding of the ratchet member in both directions over edges 573 provided on recoil member 522 to produce audible click signals during both normal dose adjustment and the measuring backflow. The dose adjustment knob 520 also includes a plurality of teeth 563 provided circumferentially along an inner surface of the dose adjustment knob, as shown. During dose adjustment, teeth 563 are located in recess 576 in the outer surface of the recoil member, as shown in Figure 25. Teeth 563, in this embodiment, serve as an injection coupling for rotationally locking the knob. dose adjustment 520 on recoil member 522. In another embodiment, the injection coupling may be between a set of dog teeth provided on recoil member 522 and dose adjustment knob 520, as similarly discussed with respect to the first embodiment shown in Figures 4A and 5A (teeth 64 and 74). The dose adjustment knob 520 comprises a plurality of threads 591 provided along its inner surface for threaded engagement with the threads 590 of the dose stop member 528.
    [084] Having described exemplary structures, aspects and mutual relationships between the particular members of Figures 20-25, the intended functionality of such an exemplary injection pen will now be described. Discussion of particular members and similar aspects of the above modalities have been omitted here.
    [085] To adjust a desired dose for injection, a user rotates the dose adjustment knob 520 in a first direction. Relative rotation between dose adjustment knob 520 and recoil member 522 produces a series of dose adjustment clicks due to engagement between edges 573 and ratchet members 564, 565. If too large a dose is adjusted By the user, the user can rotate the dose adjustment knob 520 in a second opposite direction to reflow the adjusted dose measurement. During dose adjustment, the dose adjustment knob is free to rotate in both the first and second directions with respect to recoil member 522. To inject an adjusted dose, the user presses push button 34, which pushes the recoil member 522 in the distal direction and causes edges 573 on the recoil member to engage teeth 563 provided on the dose adjustment knob. Dose adjustment knob 520 and recoil member 522 are now rotationally secured with respect to each other. Now, when the flow adjustment knob rotates back into the body 518, the recoil member 522 is also induced to rotate, which forces the actuator 524 to rotate with it. The lead screw is prevented from rotating with respect to the body 518 due to its mating engagement with the insert 530, which is pivotally fixed to the body 518 when the cartridge holder is secured to the body 518, as described above. Since the lead screw 526 is fixed with rotation, the relative rotation between the driver 524 and the lead screw 526 causes the lead screw 526 to move axially into the cartridge to inject an adjusted dose, due to the its threaded engagement with the 582 threads provided on the driver 524. During injection, when the driver 524 rotates relative to the body 518, the ratchet arms 586 produce an injection click signal as they extend over the teeth 556 provided within the body 518. In this embodiment, control of the last dose is performed similarly to that described above with respect to Figure 18, to prevent a user from setting a dose greater than the remaining volume of medication remaining in the cartridge.
    [086] Although the present invention has been shown and described with reference to particular illustrative embodiments, it should not be restricted by the exemplary modes, but only by the appended claims and their equivalents. It should be appreciated that those skilled in the art can change or modify the exemplary embodiments without departing from the scope and spirit of the present invention.
    权利要求:
    Claims (10)
    [0001]
    1. Medication injection pen comprising: a housing (18), a dose adjustment knob (220, 320, 420) rotatable with respect to said housing (18) for setting a desired injection dose, a lead screw (226, 326, 426) provided with a threaded element and can be advanced in a first direction through a corresponding threaded engagement, said first direction being that expelling medication from a cartridge (36), an actuator (224 , 324, 424) rotatably fixed to said lead screw (226, 326, 426) to prevent relative rotation therebetween, said driver (224, 324, 424) being rotatable in a first rotational direction to rotate said screw. advancing screw (226, 326, 426) and advancing said lead screw (226, 326, 426) in said first direction, a recoil member (222, 322, 422) rotatably fixed to said driver (224 , 324, 424) to prevent relative rotation between them, said recoil member (222, 322, 422) being separated from the d. the accommodation (18); and CHARACTERIZED by the fact that it further comprises a dose interrupt member (228, 328, 428) rotatably fixed to said dose adjustment knob (220, 320, 420) and comprising an internal thread in threaded engagement with said thread member of said lead screw (226, 326, 426), said dose interrupt member (228, 328, 428) being axially movable with respect to said dose adjustment knob (220, 320, 420) when said dose adjustment knob (220, 320, 420) is rotated relative to said recoil member (222, 322, 422), and at what axial movement of said dose interrupt member (228, 328, 428) limits the adjustment by a user of a dose that is greater than an injectable volume of medication remaining in the cartridge (36).
    [0002]
    2. Medication injection pen, according to claim 1, CHARACTERIZED by the fact that said dose interruption member (228, 328, 428) rotates together with said lead screw (226, 326, 426) when said lead screw (226, 326, 426) rotates in said first rotational direction.
    [0003]
    3. Medication injection pen, according to claim 1, characterized in that it further comprises: a tongue element (30) positioned between said dose adjustment knob (220, 320, 420) and said member (222, 322, 422), said pawl member (30) comprising a first arm member engaging an inner surface of said dose adjustment knob (220, 320, 420), and a second arm member engaging an outer surface of said recoil member (222, 322, 422), wherein one of said first and second arms produces an audible signal when said dose adjustment knob (220, 320, 420) is rotated with respect to the said housing (18), wherein said inner surface of said dose adjustment knob (220, 320, 420) and said outer surface of said recoil member (222, 322, 422) each comprise a plurality of of teeth, and one of said first and second arms slide over edges of said plurality of teeth of said member of setback (222, 322, 422) or edges of said plurality of teeth of said dose adjustment knob (220, 320, 420) to produce the audible signal on each edge.
    [0004]
    4. Medication injection pen according to claim 3, CHARACTERIZED by the fact that said plurality of teeth of said dose adjustment knob (220, 320, 420) are configured to allow relative rotation between said dose knob. dose adjustment (220, 320, 420) and said pawl member (30) in a second rotational direction, and said plurality of teeth of said recoil member (222, 322, 422) are configured to allow relative rotation between said recoil member (222, 322, 422) and said pawl member (30) in a direction opposite to the second rotational direction.
    [0005]
    5. Medication injection pen, according to claim 4, CHARACTERIZED by the fact that when said dose adjustment knob (220, 320, 420) rotates relative to said tongue element (30) in said second direction rotational, said first arm produces the audible signal, and when said recoil member (222, 322, 422) rotates relative to said pawl member (30) in said direction opposite said second rotational direction, said second arm produces the audible signal.
    [0006]
    6. Medication injection pen according to claim 1, CHARACTERIZED by the fact that said housing (18) further comprises a flexible protrusion provided on a surface within said housing (18), and said adjustment knob. The dose (220, 320, 420) further comprises a flexible tab member that engages said protrusion to produce an audible signal upon completion of injection of an adjusted dose.
    [0007]
    7. Medication injection pen, according to claim 6, CHARACTERIZED by the fact that when said dose adjustment knob (220, 320, 420) rotates relative to said housing (18) to adjust an injection dose desired, said flexible tab member passes between a first edge of said protrusion and a side wall of the housing (18), causing said protrusion to flex away from said side wall.
    [0008]
    8. Medication injection pen, according to claim 7, CHARACTERIZED by the fact that said dose adjustment knob (220, 320, 420) rotates in an opposite direction to inject a dose, and in that direction, said flexible tab element engages a second edge of said protrusion causing said flexible tab element to flex radially inward, wherein once said flexible tab element passes an end of said protrusion, said flexible tab element returns to a position while providing an audible signal indicating an end of injection.
    [0009]
    9. Medication injection pen, according to claim 1, CHARACTERIZED by the fact that said recoil member (222, 322, 422) moves axially or rotates in relation to the housing (18) during adjustment or injection of dose.
    [0010]
    10. Medication injection pen, according to claim 9, CHARACTERIZED by the fact that the housing (18) includes a channel having internal threads that threadedly engage the thread element of said lead screw (226, 326, 426); said channel includes a wall disposed on an upper surface of said channel; and said flexible protrusion is disposed on said wall of said channel.
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5725508A|1994-06-22|1998-03-10|Becton Dickinson And Company|Quick connect medication delivery pen|
    WO1999038554A1|1998-01-30|1999-08-05|Novo Nordisk A/S|An injection syringe|
    US6248095B1|1998-02-23|2001-06-19|Becton, Dickinson And Company|Low-cost medication delivery pen|
    JP4290366B2|1999-08-05|2009-07-01|ベクトン・ディキンソン・アンド・カンパニー|Drug delivery pen|
    TW453884B|1999-09-16|2001-09-11|Novo Nordisk As|Dose setting limiter|
    US6663602B2|2000-06-16|2003-12-16|Novo Nordisk A/S|Injection device|
    US20040097883A1|2000-10-09|2004-05-20|Roe Michael Joseph|Pen device for administration of parathyroid hormone|
    CA2440873C|2001-03-27|2010-12-07|Eli Lilly And Company|Kit including side firing syringe needle for preparing a drug in an injection pen cartridge|
    JP4283545B2|2001-05-16|2009-06-24|イーライリリーアンドカンパニー|Drug injection device with simplified reset drive assembly|
    WO2003080160A1|2002-03-18|2003-10-02|Eli Lilly And Company|Medication dispensing apparatus with gear set for mechanical advantage|
    CA2500195C|2002-09-24|2009-07-21|Shl Medical Ab|Injecting device|
    DE60308042T2|2002-10-01|2007-04-12|Becton Dickinson And Co.|PEN DRY MEDICATION SYRINGE|
    GB0304823D0|2003-03-03|2003-04-09|Dca Internat Ltd|Improvements in and relating to a pen-type injector|
    US6932794B2|2003-04-03|2005-08-23|Becton, Dickinson And Company|Medication delivery pen|
    CA2530263C|2003-08-12|2012-04-17|Eli Lilly And Company|Medication dispensing apparatus with triple screw threads for mechanical advantage|
    DE202004006611U1|2004-04-23|2005-08-25|Tecpharma Licensing Ag|Injection device for administering an injectable product with secured dosing device|
    WO2006079481A1|2005-01-25|2006-08-03|Novo Nordisk A/S|An injection device with an end of dose feedback mechanism|
    US8257318B2|2005-02-11|2012-09-04|Novo Nordisk A/S|Injection device having a rotatable scale drum|
    EP1861141B1|2005-02-17|2013-12-18|Novo Nordisk A/S|A dose setting element for an injection device and having a dose setting limiting mechanism|
    JP4827922B2|2005-07-27|2011-11-30|ノボ・ノルデイスク・エー／エス|Dosing mechanism of an injection device that limits the setting of the dose corresponding to the remaining amount of the drug|
    US8574199B2|2006-07-03|2013-11-05|Novo Nordisk A/S|Coupling for injection devices|
    DE202007014852U1|2007-03-22|2008-03-06|Tecpharma Licensing Ag|Dosing with overload protection|
    DE102007054020A1|2007-11-13|2009-05-14|Tecpharma Licensing Ag|Injection device with uncoupling click mechanism|SG10201700601VA|2011-03-16|2017-03-30|Becton Dickinson Co|Multiple use disposable injection pen|
    US8784388B2|2011-09-30|2014-07-22|Becton, Dickinson And Company|Syringe with disinfecting tip feature|
    KR101680437B1|2011-10-17|2016-11-28|에스에이치엘 그룹 에이비|Medicament delivery device|
    BR112014013632A8|2011-12-08|2017-06-13|Unitract Syringe Pty Ltd|Precise dose mechanisms and drug delivery syringes|
    JP6214549B2|2011-12-08|2017-10-18|サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング|Drive assembly for a drug delivery device and drug delivery device comprising the drive assembly|
    CH703993A2|2012-02-09|2012-03-15|Tecpharma Licensing Ag|Injection device for dispensing fluid product, has bearing coupling surfaces that are formed in coupling mechanism to produce acoustic/tactile signals corresponding to adjusted or corrected dose during dose dispensing process|
    DK2825227T3|2012-03-15|2019-07-29|Becton Dickinson Co|Disposable syringe for many applications|
    CH706567A2|2012-05-16|2013-11-29|Tecpharma Licensing Ag|Improved device to set a dose a limiting mechanism for an apparatus for administering a product.|
    EP2900299B1|2012-09-27|2020-07-08|Aptar France SAS|Autoinjector|
    JP2015533321A|2012-11-08|2015-11-24|サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング|Dose setting mechanism of drug delivery device|
    CN103041476B|2012-12-04|2017-12-12|邓源基|Adjustable dosage syringe|
    EP2950853B1|2013-02-01|2017-03-15|Novo Nordisk A/S|A non-axial working end-of content mechanism and an injection device comprising the same|
    BR112015024187A2|2013-04-10|2017-07-18|Sanofi Sa|injection device|
    US10201662B2|2013-04-10|2019-02-12|Sanofi|Injection device and assembly method|
    JP6366680B2|2013-04-10|2018-08-01|サノフイ|Drive mechanism of drug delivery device|
    WO2014166907A2|2013-04-10|2014-10-16|Sanofi|Drive mechanism for a drug delivery device|
    JP2016518901A|2013-04-10|2016-06-30|サノフイ|Injection device|
    BR112015023941A2|2013-04-10|2017-07-18|Sanofi Sa|injection device|
    WO2014166888A1|2013-04-10|2014-10-16|Sanofi|Injection device|
    WO2014195270A1|2013-06-04|2014-12-11|Novo Nordisk A/S|Torsion spring injection device having an end-of-dose mechanism|
    DK3021909T3|2013-07-17|2019-04-29|Sanofi Sa|PHARMACEUTICAL MANAGEMENT DEVICE|
    EP3021913B1|2013-07-17|2017-09-27|Sanofi|Drug delivery device|
    EP3021910B1|2013-07-17|2020-05-27|Sanofi|Drug delivery device|
    JP6412569B2|2013-07-17|2018-10-24|サノフイＳａｎｏｆｉ|Drug delivery device|
    MX2016001245A|2013-08-02|2016-05-24|Becton Dickinson Co|Injection pen.|
    EP3041542A1|2013-09-03|2016-07-13|Sanofi|Drive mechanism for a drug delivery device|
    EP3057629B1|2013-10-16|2021-12-08|Novo Nordisk A/S|Drug delivery device with brake mechanism|
    DK3068471T3|2013-11-15|2020-03-23|Sanofi Aventis Deutschland|PART AND DEVICE FOR PHARMACEUTICAL ADMINISTRATION, PHARMACEUTICAL ADMINISTRATION AND USE OF PART|
    CA2943554C|2014-04-03|2019-02-26|Cc Biotechnology Corporation|Syringe|
    US10596332B2|2014-04-29|2020-03-24|Shl Medical Ag|Device for adjusting needle insertion depth|
    AU2015269605A1|2014-06-06|2016-10-27|Eli Lilly And Company|Rotatable end of dose feedback mechanism|
    CN105233373B|2014-06-26|2018-05-18|群康生技股份有限公司|The cycling switch mechanism of syringe|
    CN105288790B|2014-06-26|2018-07-03|群康生技股份有限公司|Syringe|
    CN105311714B|2014-06-26|2018-08-17|群康生技股份有限公司|The spiral-guide mechanism of syringe|
    TW201603852A|2014-07-01|2016-02-01|賽諾菲公司|Spring arrangement and drug delivery device herewith|
    TW201603851A|2014-07-01|2016-02-01|賽諾菲公司|Drug delivery device|
    US10471218B2|2014-07-01|2019-11-12|Sanofi|Drug delivery device|
    CN104491956B|2014-12-30|2017-03-08|江苏德尔福医疗器械有限公司|A kind of injection pen|
    EP3045193A1|2015-01-19|2016-07-20|Sanofi-Aventis Deutschland GmbH|Assembly for a drug delivery device|
    EP3270989B1|2015-03-19|2019-06-05|SHL Medical AG|Dose setting mechanism and medicament delivery device comprising the dose setting mechanism|
    CN105477744A|2015-06-11|2016-04-13|江苏德尔福医疗器械有限公司|Dose-fixable disposable injection pen|
    WO2017001692A1|2015-07-01|2017-01-05|Novo Nordisk A/S|Drug delivery device with priming mechanism|
    PL227678B1|2015-12-22|2018-01-31|Copernicus Spólka Z Ograniczona Odpowiedzialnoscia|Control and drive system for the device intended for injection and the device for making injections equipped with such a system|
    EP3187217A1|2015-12-29|2017-07-05|Galderma S.A.|Syringe with click mechanism|
    WO2017138819A1|2016-02-11|2017-08-17|Medical Plastics Limited|An apparatus for dispensing a medicament|
    WO2017158033A1|2016-03-15|2017-09-21|Sanofi|Dosing mechanism for multi-shot injection device comprising flexible ratchet element|
    PL3108914T3|2016-07-07|2019-08-30|Copernicus Sp. Z O.O.|Injection device for delivering a defined number of equal doses of a liquid substance|
    RU2653688C1|2017-01-19|2018-05-11|Бектон, Дикинсон Энд Компани|Disposable syringe-pen for several doses|
    JP6412963B2|2017-01-20|2018-10-24|ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ|Multi-use disposable injection pen|
    US10688247B2|2017-07-13|2020-06-23|Haselmeier Ag|Injection device with flexible dose selection|
    RU2696459C1|2019-02-21|2019-08-01|Общество с ограниченной ответственностью «НЭКСТ БИО»|Injection device|
    EP3520844A1|2019-05-07|2019-08-07|Tecpharma Licensing AG|Dosing device for an injection device|
    RU2729432C1|2019-10-23|2020-08-06|Общество с ограниченной ответственностью «НЭКСТ БИО»|Device for drug delivery|
    EP3884974A1|2020-03-27|2021-09-29|Becton, Dickinson and Company|Improved systems, components, and combinations thereof for pen-type injection devices|
    法律状态:
    2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-07-23| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-05-26| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2020-11-03| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2021-03-16| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-05-04| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/11/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF |
    优先权:
    申请号 | 申请日 | 专利标题
    US26556209P| true| 2009-12-01|2009-12-01|
    US61/265,562|2009-12-01|
    US35146510P| true| 2010-06-04|2010-06-04|
    US61/351,465|2010-06-04|
    PCT/US2010/003059|WO2011068531A1|2009-12-01|2010-11-30|Injection pen with dial back and last dose control|BR122020008868-0A| BR122020008868B1|2009-12-01|2010-11-30|INJECTION PEN WITH LAST DOSE MEASUREMENT AND CONTROL REFLUX|
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