• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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  • 优先权
    • 专利摘要:
    injection device - an injection device comprises a housing (101, 102) for a cartridge or syringe, a plunger (40) to cooperate, in use, with the cartridge or syringe to express successive doses, a dose adjustment arrangement (button dose adjustment 16.20) to select a dose volume, and a releasable drive mechanism (22, 24) for advancing said plunger in respective predetermined increments of magnitude to express said successive doses. the actuation mechanism includes an actuation spring (22) to provide movement directly or indirectly to said piston (40), and said adjustment arrangement comprises a dose adjustment element (16) movable in a dose adjustment routine for define a magnitude of movement increments of said plunger for a given dose. the drive mechanism further includes a clutch arrangement (56) operable during said dose adjustment routine to inhibit movement in front of the plunger and / or to isolate said dose adjustment element from the force of said pressure spring drive.
    公开号:BR112012008859A2
    申请号:R112012008859-9
    申请日:2010-10-15
    公开日:2020-05-12
    发明作者:Cowe Toby
    申请人:Owen Mumford Limited；
    IPC主号:
    专利说明:

    “INJECTION APPLIANCE”
    The invention relates to injection devices and, in particular, but not exclusively, such devices used to inject multiple doses of varying magnitude, for example, insulin.
    In our previous Autopen® device, a rotary dose adjustment knob, attached to the rear end of the pen-type injector, is connected to a hollow actuation sleeve that carries an annular ratchet surface at its front end that engages a corresponding ratchet surface in a threaded drive collar. The threaded drive collar is threadedly engaged with a piston rod so that the rotating movement of the drive collar is converted into a linear piston advance. A trigger can be moved to release the drive collar for rotary movement. During a dose adjustment routine, with the actuation collar retained against rotation by the trigger, a dose is selected by rotating the dose adjustment button and the actuation sleeve against a spring tension provided by a main actuation spring. The dose adjustment movement is unidirectional only due to the ratchet action between the drive sleeve and the drive collar. When releasing the trigger, the actuation collar rotates by an angular amount, equivalent to the angular amount initially selected, and the plunger is advanced by the corresponding amount to dispense the required number of units.
    This device behaves extremely well and has considerable success, but we have identified a number of opportunities for improvement. In the device above, when adjusting a dose, the user rolls the spring to provide the driving force that is needed for the next dose. This means that it can be uncomfortable for those of limited dexterity to exercise enough grip to turn the dose adjustment knob against the tension of the actuation spring. Also in this project, because the dose adjustment action coils the actuation spring, a ratchet action is required so that, when the user releases his grip on the dose adjustment button, the button remains in this position and does not return immediately to the zero position under the influence of the actuation spring. To allow for reversal of dose adjustment in the event of over-adjustment, a bidirectional ratchet mechanism is then required, or otherwise a disconnect mechanism, either of which complicates the device.
    Therefore, we have designed an injection apparatus in which a clutch arrangement is provided to isolate the dose adjustment element from the force of the ai spring during the dose adjustment routine.
    Accordingly, in one aspect, this invention provides an injection apparatus for use with a cartridge or syringe to dispense a plurality of doses therefrom, the injection apparatus comprising:
    a housing for the cartridge or syringe;
    a plunger to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement for selecting a dose volume;
    a releasable drive mechanism for advancing said plunger in respective predetermined increments of magnitude to express said selected successive doses;
    characterized by the fact that said actuation mechanism includes a actuation spring to apply expulsion actuation movement directly or indirectly to said plunger, and said dose adjustment arrangement comprises a mobile dose adjustment element in a routine dose adjustment to adjust a magnitude of an increase in movement of said piston for a given dose, said drive mechanism further including an operable clutch arrangement during said dose adjustment routine to isolate said dose adjustment element a from the force of said actuation spring and optionally to directly or indirectly inhibit the forward movement of the piston.
    In an arrangement where the dose adjustment element is isolated from the force of the actuation spring during the dose adjustment routine, the dose adjustment element can be easily rotated, and also preferably can be moved in the reverse direction if the user moves the dose adjustment element after a required dose. The isolation of the dose adjustment element means that the dose adjustment movement of said dose adjustment element is not resisted by said spring.
    It follows from the above that, if the dose adjustment action does not energize the actuation spring, the actuation spring must be energized in some way. Conveniently, the actuation spring is preloaded to an extent sufficient to substantially dispense the entire usable contents of the syringe or cartridge in a succession of doses. Where the dose adjustment element is isolated from the force of the actuation spring during the dose adjustment routine a more powerful spring can be used, which would be appropriate for the conventional device wound by the user. Instead of providing a fully preloaded actuation spring, the actuation spring could be partially preloaded or without any preload, but with separate devices suitable for energizing the spring. It will be appreciated that in such arrangements, the drive mechanism will usually already be under load from the drive spring before dose adjustment, in contrast to the prior art devices, where the drive mechanism is under load only once the dose was selected.
    Preferably, the dose adjustment member is movable at an angle to adjust said increase in piston movement.
    The clutch arrangement preferably includes a movable clutch element between disengaged and engaged positions. Thus, the clutch element can be adapted to move axially with said dose adjustment element, whereby the axial movement of said dose adjustment element from one from a first resting position to a second position dose adjustment causes said clutch element to engage to inhibit forward movement of said piston. It is also convenient that the dose adjustment element and said housing include complementary contacts that engage to prevent the relative rotation of said dose adjustment element in relation to said housing when said dose adjustment element is in its resting position. , but which disengage to prevent dose adjustment rotation of the dose adjustment element when it is in its adjustment position. In this way, the dose adjustment element can be moved axially from said resting position to its adjustment position, then rotated to select in a required dosing volume, and then returned axially to its resting position to lock it. again against rotation.
    Preferably, in the movement of the dose adjustment element from its resting position to its adjustment position, the clutch element engages, to inhibit the movement of the actuation piston for a predetermined distance before contacting the adjustment element of dose and housing disengage to release the dose adjustment element for the dose adjustment movement.
    In a preferred arrangement, when the dose adjustment element is in its resting position, it receives and reacts to the impulse of the actuation spring so that the dose adjustment element thus inhibits the movement of the actuation piston. In this way, when the dose adjustment element is in its resting position, the impulse of the actuation spring is reacted by the dose adjustment element and, consequently, to the housing, but, when the dose adjustment element is in its adjustment position, the impulse of the actuation spring is reacted by the clutch member having engaged with the housing.
    Preferably, having adjusted a dose, returning the dose adjustment element axially to its first position disengages the clutch element to release the drive mechanism to cause the piston to advance by a predetermined increment corresponding to the predetermined adjusted dose.
    Preferably, said piston is threadedly engaged with an associated control or drive element, whereby the advance of said piston is carried out by rotation of the piston or of the drive or control element, with the magnitude of the incremental feed being adjusted by restricting said rotation.
    Preferably, a stop member is associated with the dose adjustment element and is adjustable by the movement of the dose adjustment element, thus defining an angular increment for the relative rotation between the piston and the actuation or control element in the release of the drive mechanism.
    The stop member could simply be a contact surface provided in the dose adjustment element. This would allow the maximum usable extent of angular movement of the dose adjustment element to be only less than 360 °. This would mean that the necessary indications would need to be closely gathered in some cases. Therefore, it is preferred that an intermediate selection or bidirectional element is provided screwed with the dose adjustment element and restricted to rotate with a rotary between the piston and the control member, with the relative angular movement extension of the member. selection or bidirectional and the dose adjustment element being adjusted by the relative position of the stop member associated with the dose adjustment element. The provision of a threaded selection or bidirectional member means that it is now possible to adjust a dose of several turns. This has advantages both in terms of the size available for the indications, and also allows greater flexibility in the choice of the thread pitch between the piston and the control member. In a particularly preferred arrangement, the dosage indications can be provided as a helical strip over one of the complementary dose adjustment elements, and read via a marker or window on the other dose adjustment element.
    The actuation spring, in the various arrangements described above, can be either a torsion spring that gives a rotary movement when released, or a compression spring that gives a linear movement.
    In many applications, it may be desirable to provide a multiple dose injection device, which is supplied preloaded, so that it is not necessary to re-energize the drive between each dose, for example, if the device is intended to be disposable.
    Therefore, in another aspect, this invention provides an injection apparatus for use with a cartridge or syringe to dispense a plurality of doses therefrom, the injection apparatus comprising:
    a housing for the cartridge or syringe;
    a plunger to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement for selecting a dose volume;
    a releasable drive mechanism for advancing said plunger in respective predetermined increments of magnitude to express said successive doses;
    characterized by the fact that said drive mechanism includes a rotating stored energy element with sufficient preload to dispense at least a plurality of said successive doses.
    In the arrangement above, the injection apparatus can, for example, be provided with a fully preloaded spring so that the user is not required to supply the mechanical energy required to express the doses. This makes the device particularly suitable for those with limited dexterity or poor gripping ability.
    As noted above, conventional Autopen® and similar devices have an angular range of dose adjustment movement that is limited to 360 °, and this places restrictions on the marking indications, the drive thread pitch, and the spring properties drive. Therefore, we have designed an arrangement in which the dose adjustment arrangement includes first and second, complementary dose adjustment elements, screwed in, which allows the dose adjustment movement for several turns, if required.
    Accordingly, in another aspect of this invention, an injection apparatus is provided for use with a cartridge or syringe to dispense a plurality of doses therefrom, the injection apparatus comprising:
    a housing for the cartridge or syringe;
    a plunger to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement for selecting a dose volume;
    a releasable drive mechanism for advancing said plunger in respective predetermined increments of magnitude to express said successive doses and wherein the advancement of said plunger is controlled by a control member that moves angularly in response to the advancement of said plunger;
    characterized by the fact that said dose adjustment arrangement includes first and second complementary dose adjustment elements threadedly engaged for relative threaded movement away from a first limit position, with said first dose adjustment element being movable in relation to said accommodation in an adjustment routine from a resting position to a variable angular position that adjusts the dose volume, said second dose adjustment element being restricted to rotate with said control element, so , in releasing said drive mechanism, said control member and said second member rotate until the second member returns to said first limit position with respect to the first member and prevents further rotation of the control member.
    According to another aspect, the invention provides an injection apparatus for use with a cartridge or syringe to dispense a plurality of doses therefrom, the injection apparatus comprising:
    a housing for the cartridge or syringe;
    a plunger to cooperate with the cartridge or syringe to express successive doses;
    a drive mechanism energized by a drive spring, and releasable to advance said piston in predetermined increments as determined by the adjustment of a dose adjustment element, and a re-energization element to re-energize said spring regardless of movement said dose adjustment element.
    Preferably, said actuation spring is a torsion spring and said re-energizing element is a rotating element.
    According to another aspect, the invention provides an injection apparatus for use with a cartridge or syringe to dispense a plurality of doses therefrom, the injection apparatus comprising:
    a housing for the cartridge or syringe;
    a plunger to cooperate, in use, with the cartridge or syringe to express successive doses;
    a mobile dose adjustment element for selecting a dose volume;
    a releasable drive mechanism for advancing said plunger in respective predetermined increments of magnitude to express said dose volumes, said drive mechanism including a driving spring to provide driving force directly or indirectly to said plunger to advance said plunger , and the apparatus being configurable between a first position in which the driving force of the actuation spring is transmitted via the dose adjustment element to the housing to be so reacted, and a second position in which a clutch element is moved to a position in which the driving force of the actuation spring is transmitted via the clutch element to the housing to be so reacted, so that the dose adjustment movement of the dose adjustment element is not resisted by the actuation spring.
    Although the invention has been described above, it extends to any inventive combination of the features set out above or in the following description of the claims.
    The invention can be carried out in several ways, and a modality of it will now be described only by way of example, reference being made to the attached drawings, in which:
    figure 1 is a side view of a first type of pen-type injector according to this invention;
    figure 2 is a side section view of the pen-type injector of figure 1;
    figure 3 is an exploded view of the pen-type injector of figures 1 and 2;
    figure 4 is an enlarged view of the main body of the pen-type injector of figures 1 to 3, containing the actuation mechanism, with a body shown by the transparent half;
    figure 5 is a perspective section view of the dose adjustment button showing the thread inside the dose adjustment button;
    figure 6 is a perspective section view of the rear of the drive mechanism showing the clutch and dose adjustment knob and dose scale disc;
    figure 7 is an exploded view of a second embodiment of a pen-type injector according to the invention, having a rewinding equipment;
    figure 8 is a detailed view of the rewinding button, and figure 9 is a side section view of a third mode of the pen-type injector driven by a compression spring.
    The mode of the pen type injector, illustrated in figures 1 to 6, is designed to be a pen type injector, automatic and disposable, capable of expelling a succession of doses of variable preset magnitude from a cartridge. The injector comprises a body made of symmetrical 10 1 and 10 2 body halves, which can be snapped together or glued together. A cartridge or syringe 12 is received in a transparent front cartridge housing 14, which is a quick fit fitting on the front end of the body halves 10 1 , 10. At the rear end of the body, a dose adjustment button 16 is mounted which has a window 18, through which a dose scale disk 20 is visible. As will be described below, the device contains a preloaded torsion spring which, in this particular embodiment, provides the entire force required to expel the entire usable dose volume in the cartridge. Doses are adjusted by pulling the dose adjustment knob 16 backwards, rotating it until the required dosing unit is visible on the dose scale disc and then pushing the dose scale disc back to release the drive mechanism. to expel the required dose.
    With reference now more particularly to figures 2, 3 and 4, the body 10,10 defines an internal cylindrical space in which a torsion spring 22 is positioned in an energized state, with the front end of the spring being fixed in a part 23 of the body. A hollow tubular drive shaft 24 is arranged concentrically within the spring having a radial flange 26 which is rotatably retained within an annular recess 28 at the front of the body to allow rotation of the shaft, but to prevent its axial movement. Towards its rear end, the shaft diameter increases by a shoulder 30 in which an anchoring hole 32 is provided for the rear end of the actuation spring. When assembled and before its first use, the torsion spring 22 is fully energized and acts on the drive shaft to rotate it in the direction of dispersion. The enlarged portion 34, adjacent to the shoulder 30, with four of the grooves 38 at 90 ° extending the full length of the enlarged portion 34.
    At the front end, the drive shaft has an internally threaded hole 38, into which the lead thread of a plunger 40 is threaded. The plunger has an enlarged head 42 which engages the threaded plug 44 of the cartridge 12. Immediately behind the head widened 42, the drive shaft has two keyways 46, diametrically opposed, which cooperate with respective keys 48 at the front end of the body halves 10 1 , 10 2 to allow axial movement of the piston, but prevent its rotation when drive shaft 24 rotates to advance the plunger.
    The dose scale disk 20 is slidably mounted on the widened portion 34 of the drive shaft 24, but prevented from rotating by means of four internal spaced keyways 50, which engage the longest splines 38 in the enlarged portion. The front end of the dose scale disc has an enlarged internal diameter so as to be free of the shorter grooves 36. The external surface of the dose scale disc 20 bears a coarse helical thread 21 which threadably engages a corresponding internal threaded portion 52 on the inner surface of the dose adjustment button 16. The threaded portion 52 inside the dose adjustment button 16 has a limit position adjusted by the thread termination (vertical the blind end 54 in the figure
    5). A rear limit position stop can optionally be provided, for example, on the inside of a hinged lid portion 17 of the dose adjustment button.
    The dose adjustment knob 16 is connected at its front end to a clutch collar 56 by means of a quick-fit adjustment that allows the clutch and the dose adjustment knob to rotate in relation to each other, but counter axial movement (see figure
    6). The clutch collar 56 is mounted for sliding movement on the body 10, but is prevented from rotating with respect to it by means of two tongues 58 on the body by engaging respective opposing slots 60 on the cylindrical wall of the clutch collar 56. At its rear end, the clutch collar 56 has an internal splined arrangement 57, designed to slide into the splined coupling with the splines 56 in the widened portion 34 of the drive shaft in order to lock the drive shaft against movement under the influence of the spring by the reaction of the thrust into the body by means of the tabs 58. Referring now more particularly to figures 4 to 6, the front end of the dose adjustment knob 16 has a series of axially extending fingers 62, which are and an adjustment of axial slide with a series of pockets 64 provided in the body.
    The axial lengths of the fingers 62 and the bags 64 are carefully selected with respect to the axial spacing between the internal splines 57 on the clutch collar and the extreme splines 36 on the drive shaft 24, so that, when pulling the adjustment knob, dose 16 outwardly axially, the splines 57 on the clutch collar 56 engage the splines 36 on the drive shaft 24 at some distance before the fingers 62 of the dose adjustment knob 16 are removed axially from the bags 64 in the body. The reason for this is that, in the position shown in figure 2, as indicated above, the impulse of the drive spring is transmitted via the drive shaft splines 38 to the dose scale disk 20 and, consequently, to the button dose adjustment 16 (due to the dose scale dial being in its front limit position in relation to the dose adjustment button). It is therefore important to ensure that the clutch 56 has engaged the drive shaft 24 to react to the load of the torsion spring 22 through the clutch 56 and the tabs 58 into the housing before the dose adjustment button has been removed enough to rotate.
    Once the dose adjustment knob has been removed sufficiently to disengage fingers 58 from bags 64, it is in an adjustment position in which it can be rotated to adjust a dose against a slight stopping action provided by the fingers 62, which provide an audible / tactile click to allow the user to count the number of units selected. It will be appreciated that during dose adjustment, body 10, drive shaft 24, clutch 56, all remain stationary, both axially and rotationally. The dose scale disk is fixed against rotation due to its splined engagement with the large portion 34 of the drive shaft, but it is capable of axial movement. Thus, in this condition, with the dose adjustment knob 16 axially in its adjustment position, rotation of the dose adjustment knob in the appropriate direction moves the dose scale disk 20 axially in a lead screw manner. The dose scale dial numbers are visible through window 18. The threaded engagement allows multiple turns of the dose adjustment knob. Also at this point there is no loading between the dose scale disc and the cap and, thus, there is little resistance to the rotation movement of the dose add button, apart from that provided by the holder.
    Once the required dose has been selected on the helical scale, the device is ready for firing. In this arrangement, this is achieved by pushing the dose adjustment button 16 back in. When the dose adjustment knob is pushed back in, the fingers 62 re-engage the bags and then the clutch 56 is moved forward out of the widened portion of the drive shaft to disengage it, so that the drive shaft is now free to rotate. The drive axis rotates by the selected angular quantity.
    In the above arrangement, when dose adjustment is independent of the actuation spring, the length and force of the operating stroke can be reduced to design a device in which a large dose is provided with a small movement and force. This contrasts with existing devices, in which the user must apply a large user movement to adjust a dose and / or expel the adjusted dose.
    There is a potential problem with existing multi-dose devices, where, after a dose has been expelled, the plunger remains in contact with the threaded plug. Due to the friction between the threaded plug and the cartridge wall and its resilience, at the end of an injection the threaded plug will be under residual compression. Vibrations transmitted to the threaded plug or via the plunger or cartridge wall can cause the threaded plug to expand slightly and expel a drop that can affect dose accuracy. As a modification of the above embodiment, the clutch arrangement can be designed so that, when it is pulled to disengage, it retracts the plunger 40 from the threaded plug 44 a fraction, so that the threaded plug 44 is discharged.
    This unloading effect can be achieved, for example, by placing a slight shape of the splines 57 of the clutch collar 56 and on the splines 36 of the drive shaft 24 so that when the dose adjustment knob is pulled out to engage the clutch collar 56 on the drive shaft, the drive shaft is rotated by a few degrees against the spring tension to discharge the threaded plug.
    While in this modality the body is formed in two separate halves, it can, on the other hand, be formed in a shell-type arrangement where the two halves are articulated by a living hinge.
    To facilitate manufacturing, the torsion spring in the illustrated embodiment can be formed with a wave or compression portion at its front end to apply a light axial load to the cartridge in order to keep the cartridge firmly in a forward position. This allows variations in length due to production variances to be accommodated. In addition, although the metal wire that is coiled to form the spring may be circular in section in some applications, it is preferred that it be non-circular, such as square or rectangular.
    Referring now to figures 7 and 8, a second embodiment provides an arrangement for rewinding the plunger 40 and simultaneously energizing the actuation spring 22 (see figures 3 and 4) of the first embodiment. In the second modality, most components are similar to that of the first modality and will not be described again and they will be given the same reference numbers. With reference to figure 7, the front part of the housing defining the keys 48 that engage the keyways 46 in the piston driving spindle is formed as a separate rewinding button 70 which is rotatable unidirectionally about the longitudinal axis of the housing. The button 70 is formed of two halves 70 1 , 70 2 and defines a central opening with the keys 48 diametrically opposite. The button 70 has an outer circumferential groove 72, on the base of which are two diametrically opposed heel locking teeth 74, as seen in figure 8. The button 70 is rotatably received at the front end of the housing by means of an annular rib indentation directed inward 76 positioning itself in the groove 72 and cooperating with the ratchet teeth 74 to allow rotation in only one direction. The rear end of the rewinding button 70 is provided with two slots 76, within one of which the front end of the torsion actuation spring 22 (not shown) is fixed. The engagement of the keys 48 on the button 70 with the keyways 46 on the piston driving spindle 40 ensures that the piston 40 rotates with the button in only one direction, but is capable of axial sliding movement. The button and plunger can therefore be rotated in the direction permitted by the ratchet to wind the actuation spring 22 and to retract the plunger back to the actuation shaft 24 by virtue of the threaded engagement between the plunger driving spindle 40 and the drive shaft.
    The rewinding button will normally be accessible only when the cartridge housing (see the first embodiment) has been removed from the body.
    In the above arrangements, a torsion spring provides the driving force to expel the usable contents from the cartridge. Of course, it will be possible to use other appropriate drive configurations. For example, as shown in figure 9, the torsion spring could be replaced by a compression spring 80 that is present on the piston 82 to apply a thrust in the longitudinal direction. In this case, instead of the drive shaft, a drive control shaft 84 is provided which is used to modulate the movement in front of the piston 82 under the influence of the compression spring 80.
    The rear end of the plunger 82 is formed with a threaded portion that threadably engages an internal hole in the drive control shaft 84 so that when the plunger 82 is tensioned forward by the compression spring, the drive control shaft rotates.
    The drive control shaft 84 is formed at its rear end with an enlarged portion 34 provided with vertical grooves 36, similar to those of the drive shaft 24 of the first embodiment, and fulfilling a similar function in conjunction with a clutch collar 56, the dose adjustment button 16 and the dose scale dial 20 of the first embodiment. The construction and operation of these elements will not be described again in detail. As previously, the drive control shaft 84 is alternately retained and released by the clutch collar 56 and the dose adjustment button 16.
    权利要求:
    Claims (22)
    [1]
    1. Injection apparatus for use with a cartridge (12) or syringe to dispense a plurality of doses from it, the injection apparatus comprising:
    a housing (10 1 , 10 2 ) for the cartridge or syringe;
    a plunger (40) to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement (16, 20) for selecting a dose volume;
    a drive mechanism (22, 24) releasable for advancing said plunger in respective predetermined increments of magnitude to express said successive doses;
    characterized by the fact that said actuation mechanism includes an actuation spring (22) to provide movement directly or indirectly to said piston (40), and said dose adjustment arrangement comprises a dose adjustment element (16) movable in a dose adjustment routine to define a magnitude of an increase in movement of said plunger for a given dose, said drive mechanism further including a clutch arrangement (56) operable during said dose adjustment routine to inhibit the forward movement of the plunger and / or to isolate said dose adjustment element from the force of said actuation spring.
    [2]
    Injection apparatus according to claim 1, characterized by the fact that said dose adjustment element (16) is movable angled to define said increase in piston movement.
    [3]
    Injection apparatus according to claim 2, characterized by the fact that said clutch arrangement includes a movable clutch element (56) between disengaged and engaged positions.
    [4]
    Injection apparatus according to claim 3, characterized in that said clutch element (56) is adapted to move axially with said dose adjustment element (16), whereby the axial movement of said dose adjustment element from a first resting position to a second dose adjustment position causes said clutch element (56) to engage to inhibit forward movement of the piston.
    [5]
    Injection apparatus according to claim 4, characterized in that said dose adjustment element (16) and said housing (10 1 , 10 2 ) include complementary contacts (62, 64) that engage to prevent the relative rotation of said dose adjustment element with respect to said housing when said dose adjustment element is in its resting position, but disengage to prevent relative rotation between them when said dose adjustment element is in its adjustment position.
    [6]
    Injection apparatus according to claim 5, characterized in that, in the movement of said adjustment element (16) from said resting position to said adjustment position, said clutch element (56) engages before disengaging the contacts (62, 64) on said adjustment element and said housing.
    [7]
    Injection apparatus according to any of claims 4 to 6, characterized in that the impulse of the actuation spring (22) is reacted by said dose adjustment element (16) when said dose adjustment element is in its resting position.
    [8]
    Injection apparatus according to any of claims 4 to 7, characterized in that the return of said dose adjustment element (16) to said first position after having adjusted a predetermined dose disengages the clutch element ( 56) to release the drive mechanism (22, 24) to cause said plunger (40) to advance by a predetermined increment corresponding to said predetermined adjusted dose.
    [9]
    Injection apparatus according to any of claims 3 to 8, characterized in that the movement of said clutch element to its disengaged position moves said piston against the force of said spring to relieve residual load between said piston and said cartridge or syringe.
    [10]
    10. Injection apparatus according to any of the preceding claims, characterized in that the piston (40) is threadedly engaged with an associated control element (24), whereby the linear movement of said piston is accompanied by rotation of a between the piston and the control element, and the magnitude of the movement increase is controlled by limiting said rotation.
    [11]
    Injection apparatus according to claim 10, characterized in that a stop surface (54), associated with said dose adjustment element (16), is adjustable in the movement of said dose adjustment element for defining an angular increment of movement for the rotation between the piston (40) and the control element (24) in the release of said drive mechanism.
    [12]
    Injection apparatus according to claim 11, characterized by the fact that an intermediate bidirectional member (20) is threadedly engaged with said dose adjustment element (16) and is restricted to rotate with a rotary between the piston ( 40) and the control element (24), with the extension of the relative angular movement of the bidirectional member (20) and the dose adjustment element being adjusted by the relative position of the stop surface associated with the dose adjustment element.
    [13]
    13. Injection apparatus according to any of the preceding claims, characterized in that said actuation spring (22) is a torsion spring.
    [14]
    Injection apparatus according to any of the preceding claims, characterized in that said drive spring (22) is a compression spring.
    [15]
    15. Injection apparatus for use with a cartridge (12) or syringe to dispense a plurality of doses from it, the injection apparatus comprising:
    a housing (10.10) for the cartridge or syringe;
    a plunger (40) to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement (16, 20) for selecting a dose volume;
    a drive mechanism (22, 24) releasable for advancing said plunger in respective predetermined increments of magnitude to express said successive doses;
    characterized by the fact that said drive mechanism includes a rotating stored energy element (22) with a sufficient preload to dispense at least a plurality of said successive doses.
    [16]
    Injection apparatus according to claim 15, characterized in that said rotating stored energy element (22) has a preload selected to substantially dispense the entire usable contents of the syringe or cartridge over a succession of doses.
    [17]
    Injection apparatus according to claim 16, characterized by the fact that it includes devices for re-energizing said rotating stored energy element.
    [18]
    18. Injection apparatus for use with a cartridge (12) or syringe to dispense a plurality of doses from it, the injection apparatus characterized by the fact that it comprises:
    a housing (10.10) for the cartridge or syringe;
    a plunger (40) to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment arrangement (16, 20) for selecting a dose volume;
    a release mechanism (22, 24) releasable to advance said plunger in respective predetermined increments of magnitude to express said successive doses and in which the advancement of said plunger (40) is controlled by a control member (24) moves angularly in response to the advance of said plunger;
    characterized by the fact that said dose adjustment arrangement includes first and second complementary dose adjustment elements (16, 20) threadedly engaged for the relative threaded movement away from the first limit position, with said first adjustment element dose (16) being movable in relation to said housing (10, 10) in an adjustment routine from a resting position to a variable angular position that adjusts the dose volume, said second dose adjustment element ( 20) being restricted to rotate with said control element (24), so, in the release of said drive mechanism, said control member (24) and said second member (20) rotate until the second member returns to said first limit position with respect to the first member and prevents further rotation of the control member (24).
    [19]
    19. Injection apparatus for use with a cartridge (12) or syringe to dispense a plurality of doses from it, the injection apparatus comprising:
    a housing (10.10) for the cartridge or syringe;
    a plunger (40) for cooperating with the cartridge or syringe to express successive doses;
    a drive mechanism (22, 24) energized by a drive spring (22), and releasable to advance said piston in predetermined increments as determined by the adjustment of a dose adjustment element (16), and a reset element energization (70) to re-energize said spring (24) independently of the movement of said dose adjustment element (16).
    [20]
    20. Injection apparatus according to claim 19, characterized in that said actuation spring is a torsion spring and said re-energizing element is a rotating element.
    [21]
    21. The injection apparatus according to claim 20, characterized by the fact that said re-energizing element is mounted for the rotational movement in one direction over the housing by a ratchet arrangement.
    [22]
    22. Injection apparatus for use with a cartridge (12) or syringe to dispense a plurality of doses from it, the injection apparatus characterized by the fact that it comprises:
    a housing (10.10) for the cartridge or syringe;
    a plunger (40) to cooperate, in use, with the cartridge or syringe to express successive doses;
    a dose adjustment element (16) movable for selecting a dose volume;
    a releasable drive mechanism (22) for advancing said plunger in respective predetermined increments of magnitude to express said dose volumes, said drive mechanism including a driving spring (24) to provide driving force directly or indirectly to said piston to advance said piston, and the apparatus being configurable between a first position in which the driving force of the actuation spring (24) is transmitted via the dose adjustment element (16) to the housing (10) to be so reacted , and a second position in which a clutch element (56) is moved to a position in which the driving force of the actuation spring (24) is transmitted via the clutch element (56) to the housing (10) to be so reacted.
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    同族专利:
    公开号 | 公开日
    US20130046249A1|2013-02-21|
    CN104436371B|2018-08-03|
    US10806865B2|2020-10-20|
    US20210299360A1|2021-09-30|
    JP2013507996A|2013-03-07|
    WO2011045611A2|2011-04-21|
    EP2586478A3|2017-06-28|
    EP2586478B1|2021-03-10|
    EP2586477A3|2017-10-11|
    EP2488232A2|2012-08-22|
    CN102596291B|2014-11-26|
    JP2018089522A|2018-06-14|
    KR101789342B1|2017-10-23|
    EP2488232B1|2016-01-27|
    US20110092905A1|2011-04-21|
    RU2012117980A|2013-11-27|
    US8608708B2|2013-12-17|
    JP2016163721A|2016-09-08|
    KR20120102597A|2012-09-18|
    JP5922578B2|2016-05-24|
    GB201004440D0|2010-05-05|
    US9415165B2|2016-08-16|
    JP6633673B2|2020-01-22|
    JP6313358B2|2018-04-18|
    EP2586478A2|2013-05-01|
    DK2488232T3|2016-04-25|
    IN2012DN03078A|2015-07-31|
    GB0918145D0|2009-12-02|
    EP2586477A2|2013-05-01|
    CN102596291A|2012-07-18|
    US20160317752A1|2016-11-03|
    CN104436371A|2015-03-25|
    US20190192780A1|2019-06-27|
    US11033690B2|2021-06-15|
    WO2011045611A3|2011-07-21|
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    法律状态:
    2020-05-26| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-09-15| B11B| Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements|
    2021-10-19| B350| Update of information on the portal [chapter 15.35 patent gazette]|
    优先权:
    申请号 | 申请日 | 专利标题
    GB0918145.4|2009-10-16|
    GBGB0918145.4A|GB0918145D0|2009-10-16|2009-10-16|Injector apparatus|
    US12/604782|2009-10-23|
    US12/604,782|US8608708B2|2009-10-16|2009-10-23|Injector apparatus|
    US31487610P| true| 2010-03-17|2010-03-17|
    GBGB1004440.2A|GB201004440D0|2009-10-16|2010-03-17|Injector apparatus|
    GB1004440.2|2010-03-17|
    US61/314876|2010-03-17|
    PCT/GB2010/051740|WO2011045611A2|2009-10-16|2010-10-15|Injector apparatus|
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