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    • 专利摘要:
    composition, and method comprising applying the composition. a composition wherein the volatile silicon is partially or completely replaced by a vegetable oil. The vegetable oil-containing composition is equal to or better than volatile silicon material, but at a lower cost. an example comprises a blending product of at least one material chosen from antiperspirant actives and deodorant actives; more than 10% by weight of a vegetable oil; and less than 40% by weight of a volatile silicon oil. other examples comprise a blending product of more than 10% by weight of a vegetable oil; a gelling agent for the composition; and less than 40% by weight of a volatile silicon oil, wherein the composition does not contain an antiperspirant or deodorant active.
    公开号:BR112012006665B1
    申请号:R112012006665-0
    申请日:2009-09-30
    公开日:2018-01-16
    发明作者:Linn Elizabeth；Carlone Darrick；Muir Melissa；Fan Aixing；H. Misner Steven；Kilpatrick-Liverman Latonya；P. Hogan John
    申请人:Colgate-Palmolive Company；
    IPC主号:
    专利说明:

    (54) Title: COMPOSITIONS AND METHOD UNDERSTANDING APPLYING THESE COMPOSITIONS (51) lnt.CI .: A61K 8/02; A61K 8/891; A61K 8/92; A61Q 15/00 (52) CPC: A61K 8/0229, A61K 8/891, A61K 8/922, A61Q 15/00 (73) Holder (s): COLGATE-PALMOLIVE COMPANY (72) Inventor (s): ELIZABETH LINN ; DARRICK CARLONE; MELISSA MUIR; AIXING FAN; STEVEN H. MISNER; LATONYA KILPATRICK-LIVERMAN; JOHN P. HOGAN
    1/24 “COMPOSITIONS AND METHOD UNDERSTANDING APPLYING THESE COMPOSITIONS”
    BACKGROUND OF THE INVENTION
    When formulating antiperspirant products, the previous perspective was that non-volatile components, such as oils, should be minimized because they would remain on the skin after application and leave an oily feeling. Typically, volatile materials are used as the primary carrier for releasing active antiperspirant and / or deodorant to the skin. After application, volatile materials evaporate. Most commonly, volatile silicone oils, such as cyclomethicone, are used as the main volatile component.
    According to U.S. Patent No. 7,347,989 B2 to Walling et al., High levels of non-volatile organic fluids inhibit the effectiveness of the antiperspirant by preventing the release characteristics of the applied product (see column 1, lines 36 to 54).
    It would be desirable to replace the volatile silicone in an antiperspirant / deodorant product because the silicone has a limited supply, and as a result, a high cost. While it would be desirable to make the substitution, the resulting product should have the same product performance and consumer perceptions as products containing volatile silicone.
    SUMMARY OF THE INVENTION
    A composition comprising a product of mixing at least one material chosen from antiperspirant and deodorant actives; greater than 10% by weight of a vegetable oil; and less than 40% by weight of a volatile silicone oil. In one embodiment, the composition also includes a gelling agent.
    A stick composition comprising a mixing product of more than 10% by weight of a vegetable oil; a gelling agent for the composition; and
    2/24 less than 40% by weight of a volatile silicone oil, in which the composition does not contain an antiperspirant or deodorant active.
    DETAILED DESCRIPTION
    As used everywhere, ranges are used as an abbreviated form to describe each and every value that is within the range. Any value within the range can be selected as the end of the range. In addition, all references cited herein are hereby incorporated by reference in their entirety. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure prevails.
    Unless otherwise specified, all percentages and quantities expressed herein and elsewhere in the specification should be understood to refer to percentages by weight. The quantities given are based on the active weight of the material.
    The present invention includes vegetable oils (natural) in an antiperspirant / deodorant composition that overcomes the prospect that the composition will have an oily feel and leave a white residue.
    Vegetable oils
    The composition includes a vegetable oil. By vegetable oil is intended to mean that the oil is obtained from a vegetable, or vegetable oil can be made by mixing the oily components to obtain an oil that is substantially similar in composition to a vegetable oil. By substantially similar, it is intended that the manufactured oil contains the components that are discovered in the vegetable oil that is designed to imitate.
    In some embodiments, vegetable oil has a melting point below 40 ° C or below 35 ° C or below 30 ° C.
    Examples of vegetable oil include, but are not limited to, palm seed, coconut, avocado, canola, corn,
    3/24 cotton, olive, palm, sunflower with high oleic content, medium sunflower with oleic content, sunflower, palm stearin, palm seed oil, safflower, and babassu. In one embodiment, palm seed oil is the selected oil. In another embodiment, coconut oil is the selected oil. In another embodiment, vegetable oil is a combination of palm seed oil and oil oil.
    In some embodiments, vegetable oil is selected to be one that contains at least 40% by weight of C] 2 -C fatty acids | 4 . These oils provided stick products with greater resistance at the same level in the oil. In other embodiments, the oil is selected as those oils with the least amounts of unsaturation. Higher levels of unsaturation can result in an unwanted fragrance when unsaturated bonds become saturated over time. In some embodiments, the amount of unsaturated components in the oil is not more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, or 10% by weight of the oil.
    The tables below show the representative compositions of the selected oils.
    rxiéiisüojail gives Name Seed ofPalm tree Coconuts Avocado Babaçu Cinnamon Corn C6: 0 capricious <0.8 <0.6 6 you 0 C8: 0 capricious 2.4 to 6.2 4.6 to 10 0 0 0 00: 0 coprieo 2.6 to 5 5.5 to 8 0 0 0 Cl 2: 0 lauric 45 to 55 45.1 to 50.3 0 50 0 0 Cl 4: 0 nnri.stieo 14a 18 16.8 to 21 0 20 0 0 Cl 6: 0 palm 6.5 to 10 7.5 to 10.2 5 to 15 11 4a 5 11 Cl 6: 1 palinitoléieo 0 0 5 0 0 C18: 0 esleàrieo 1 to 3 2 to 4 3 3.5 1.5 to 2.5 2 Cl 8: 1 oleic 12 to 19 5 to 10 59 to 74 10 53 to 6 28 Ç18: 2 li noléicó I to 3.5 1 to 2.5 10 to 20 20 to 23 58 C18: 3 alpha linoleic 0 0 3 9 to 12 1 C20: 0 identical articju 0 0 0 0 0 C22: 0 beenieo 0 0 0 0 0 C22: l 0 0 0 <2 0 Moiwinsaturated(€ 18: 1} 12 6 71 62 28 Polyunsaturated (08: 2 and OK: 3) 2 ·> 14 32 59 Saturated (00: 0.02: 0, 04: 0.0 6: 0.08: 0) 86 92 12 6 13
    4/24
    Extensionjail gives Noiue SeedPalm tree in COCONUT Avocado Babaçu Canola Corn Dc valueTO'í ) iodine 14 to 21 6.3 to 10.6 75 to 95 110 to120 120 to 130 Point ofTO Fusion 25 to 30 20 to 28 <0 <0 <0
    Extension ofjail Name Seed ’cotton Oliveira Palm tree Sunflower High olive content Average olive content Regular C6: you eaprõieo 0 0 0 0 No data 0 C8: 0 capricious 0 0 0 0 No data 0 Cl 0: 0 £ ãpri € t> ü 0 0 0 No data 0 (Ί 2: 0 lauric 0 0 <0.5 0 No data 0 Cl 4: 0 myristian 0.6 to 1 0 0.5 to 2 0 No data 0 Cl 6: 0 pahniltco 21.4 to 26.4 7.5 to 20 39.3 to 47.5 4 No data 5 to 7.6 Cl 6: 1 palinitoleic 0 to 1.2 0 0 0 No data 0 Cl 8: 0 staphor 2.1a 3.3 0.5 to 5 3.5 to 6 6 No data 2.7 to 6.5 Cl 8: 1 oil 14.7 to 21.7 55 to 83 36 to 44 85 55 to 65 14 to39.4 CI8: 2 linolcico 46.7 to 58.2 3.5 to 21 9 to 12 5 No data 48.3 to 74 Cl 8: 3 alphalinoleum 0 to 0.4 <1.5 <0.3 0 1 0 to 0.3 C20; 0 identical here 0.2 to 0.5 <0.8 0 0 No data 0.1 to 0.5 C22; 0 becn i co It at 0.6 0 0 1) O.3 to 1.5 C22: l ententeo 0 tl 0 0 No data 0 Monounsaturated(C18: l) 19 77 39 85 58 20 Poly unsaturated(CI8; 2 and Cl 8: 3) 55 9 10 5 31 69 Saturated (CI0: 0, Cl 2: 0, Cl 4: 0,Col 6: 0, C! 8: 0) 26 14 51 10 9 11 Legg iodine value) 100 to 115 75 to 94 50 to 55 88 100 to 112 118 to141 TO melting point -O <0 37.3 <0  () - 0
    The amount of vegetable oil in the composition is more than% by weight of the composition. In some embodiments, the amount is more than 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 24, or 25% by weight in the composition. In some embodiments, the amount of vegetable oil in the composition can be up to about 50% by weight of the composition. In other embodiments, the amount is up to 49, 48, 47, 46, 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30 , 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, or 11% by weight of the composition. To form a range of quantities, any of the preceding minimum quantities can be matched to any of the preceding maximum quantities.
    5/24
    In some embodiments, the amount of vegetable oil is more than the amount of volatile silicone in the composition. In other embodiments »the amount of vegetable oil is more than
    10, 15 »20, 25, 30, 35, 40, 45» 50, 55, 60, 65, 70, 75, 80 »85, 90, or
    95% by weight of the combined weight of vegetable oil and volatile silicone (if present).
    Gel-forming agents
    Gel forming agents are those materials known in the art that structure the composition. Examples include, but are not limited to, waxes, fatty alcohol, hydrogenated vegetable oil, a hydrocarbon wax, fatty acid and fatty alcohol esters, triglycerides, or other cosmetic acceptable materials »that are solid or semi-solid at room temperature and provide a suitable consistency for application to the skin.
    1.5 In one embodiment, the hydrogenated oil is hydrogenated soybean oil. In one embodiment, hydrogenated soybean oil is almost, but not completely, hydrogenated. The amount of hydrogenation is measured by the iodine value. The iodine value can be measured by ASTM D5554-95 (2006). In one embodiment, the iodine value of the hydrogenated soybean oil used here is more than 0 to 20. In one embodiment, the iodine value is 1 to 5. In another embodiment, the oil soybean oil is completely hydrogenated with an iodine value of 0. In another embodiment, the iodine value is up to 20. Reference is made to US Patent Application Publication N ~
    2008/0187504 AL
    In one embodiment, the gelling agent includes a partially hydrogenated soybean oil having an iodine value in the range of about 75 to about 80. This partially hydrogenated soybean oil can be obtained from
    6/24
    Cargill on product indication S-500, reference is made to U.S. Patent Publication No. 2008 / 0187503A1. This material has a typical fatty acid distribution shown in the table below. Quantities are presented in% by weight.
    Cl 6: 0 10.5 to 1.2 CIO Ó.S to 7.5 CIK: I 61 to 65 CIK: 2 16 to 19 CIK1 0 to 0.2 SaUirjute 17.5 to 19.5 Trans 34 to 39
    The hydrocarbon wax can be a hydrocarbon of the formula C n H2 n +2, where n is 20 to 100, and the hydrocarbon is at least 90% linear. In one embodiment, the hydrocarbon is a paraffin. In another embodiment, the hydrocarbon is polyethylene. An example of a polyethylene can be found in US Patent No. 6,503,491. In another embodiment, the polyethylene has a weighted average molecular weight of about 300 to about 3000 and a melting point of about 50 to about 129 ° C. In one embodiment, the hydrocarbon is synthetically manufactured from methylene to form a polymethylene. Fatty alcohol can be any fatty alcohol. In one embodiment, fatty alcohol is stearyl alcohol.
    In another embodiment, the gelling agent includes hydrogenated castor oil (castor wax). In some embodiments, the melting point of the beaver wax is 70 to 90, or this can be 70, 80, or 90.
    In one embodiment, the gelling agent is a combination of hydrogenated soybean oil with a fatty alcohol or hydrocarbon. Reference is made to U.S. Patent Application No. 2008/0187504 A1.
    Fatty acids
    In some embodiments, the composition includes a fatty acid. Fatty acid is present in its acid form. While the
    7/24 fatty acids are present in vegetable oils, this is an additional amount of fatty acid that is added. In one embodiment, the fatty acid is a saturated fatty acid. In one embodiment, the fatty acid can be selected from any of the Cl6 to Cl8 fatty acids. In one embodiment, the fatty acid can be stearic acid and / or palmitic acid. The amount of fatty acid in the composition is more than 0 to 7% by weight of the composition. In other embodiments, the amount of fatty acid is at least 0.5, 1.1. 2, 3, 4, 5, or 6 to 7% by weight.
    Antiperspirant active materials
    When the composition includes an antiperspirant active, any of the antiperspirant active materials can be used in the composition. Antiperspirant actives include, but are not limited to, aluminum hydrochloride, aluminum chloride, aluminum sesquichlorohydrate, aluminum-zirconium hydroxychlorides, complexes or adducts of the aforementioned active ingredients with glycol, such as propylene glycol (eg, “Rehydrol ”II by Reheís Chemical Co.), and combinations thereof. Aluminum-zirconium salts in combination with neutral amino acids, such as glycine (for example, aluminum-zirconium tetrachloriderex Gly) can also be used. Generally, any of the Category I active antiperspirant ingredients listed in the Food and Drug Administration's Monograph on Antiperspirant Drug Products for overall-the-counter human use (October 10, 1973) can be used.
    In other embodiments, the active antiperspirant is an aluminum salt and / or an aluminum-zirconium salt, such as the one described above, which is again stabilized through betaine and a calcium salt. More information regarding the antiperspirant salts stabilized with betaine and calcium salt can be found in the Patent Application Publication
    8/24
    No. 2006/0204463 to Tang et al., Which is incorporated herein by reference only for the disclosure of active antiperspirants.
    In other embodiments, the active antiperspirant, such as that described above, is selected to have a low metal to chloride ratio. Examples of these active antiperspirants can be found in U.S. Patent No. 6,375,937 to Chopra et al. and in U.S. Patent Application No. 2004/0109833 to Tang et al., which are incorporated herein by reference only for the disclosure of the active antiperspirant.
    In other embodiments, the type of salt of interest, an aluminum zirconium tetra-salt or glycine-free octa-salt are used in which the aluminum zirconium salt is stabilized by Betaine and has a metal-to-chloride ratio of about from 0.9: 1 to about 1.3: 1 (and in other embodiments from about 0.9: 1 to about 1.2: 1 or about 0.9: 1 to about 1, 1: 1). For the tetra-salt, the Al / Zr atomic ratio can be from about 3.2: 1 to about 4.1: 1.0 and the betaine: zirconium molar ratio can be about 0.2: 1 to about 3.0: 1 (or in other embodiments from about 0.4: 1 to about 1.5: 1). Another salt that can be used is a Betaine buffered aluminum chloride salt, where the salt has a metal to chloride ratio of 0.9: 1 to 1.3: 1 (and in other embodiments of about 0.9: 1 to about 1.2: 1 or about 0.9: 1 to about 1.1: 1). For the octa-salt the Al / Zr atomic ratio is about 6.2: 1 to about 10.0: 1 the Betaine: Zr molar ratio is about 0.2: 1 to about 3, 0: 1 (or in other embodiments from about 0.4: 1 to about 1.5: 1). In one embodiment, in the case of a salt containing zirconium, betaine is incorporated during the synthesis of the salt in order to maximize the stabilizing effect that this ingredient has (especially in the zirconium species). Alternatively, it can be post-added to a glycine-free salt along with additional active phase ingredients to form a stabilized betaine asset.
    9/24
    Examples of commercially available glycine-free M: C1 low-tetra-octals and octassals include, but are not limited to, REZAL® AZP 955 CPG and REZAL® AZP 885 respectively (both from Reheis Chemical Company, Berkeley Heights, NJ). A more detailed description that makes such salts commercially available can be found, for example, in U.S. Patent Nos. 7,074,394 and 6,960,338. Other examples for making these types of saline complexes are described in U.S. Patent Application Publication No. 2004/0198998 and U.S. Patent No. 7,105,691.
    In addition to Betaine's anti-irritation properties, antiperspirant formulations have also been found to retain their fragrance stability in aging when Al / Zr salt is used in combination with Betaine.
    In addition, the active antiperspirant can be an active antiperspirant stabilized with calcium salt. Examples of calcium salt stabilized active antiperspirants can be found in U.S. Patent Application Publication No. 2006/0204463, which is incorporated herein by reference only for the disclosure of calcium salt stabilized active antiperspirants.
    In addition, any new ingredient, not listed in the monograph, such as aluminum nitrate and its combination with hydroxychlorides and zirconyl nitrates, or aluminum-tin hydrochlorides, can be incorporated as an active antiperspirant. Active antiperspirants may include, but are not limited to, the following: aluminum astringent salt, zirconium astringent salt, aluminum hydrobromide, aluminum hydrochloride, aluminum dichlorohydrate, aluminum sesquichlorohydrate, aluminum hydrochloride PG, aluminum dichlorohydrate PG, aluminum sesquichlorohydrate PG , aluminum chloride PEG, aluminum dichloride PEG, aluminum sesquichloride PEG, aluminum chloride, aluminum sulfate, aluminum zirconium hydrochloride,
    10/24 zirconium aluminum trichlorohydrate, zirconium aluminum tetrachlorhydrate, zirconium aluminum pentachlorhydrate, zirconium aluminum octachlorhydrate, zirconium aluminum tetrachloridrex propylene glycol, zirconium aluminum trichlorohydrate, zirconium aluminum, zirconium gyronium, zirconium hydroxide Zirconium glycine, buffered aluminum sulfate, potassium alum, aluminum chlorohydroxy sodium lactate. In one embodiment, the antiperspirant active is aluminum hydrochloride. In another embodiment, the antiperspirant active is zirconium propylene glycol aluminum tetrachloride.
    Active Deodorant Materials
    Any known active deodorant can be used. Examples of active deodorants include, but are not limited to, antimicrobial actives, alcohols, 2,4,4'-trichloro-2'-hydroxy diphenyl ether (Triclosane), benzethonium chloride, polyamethylene biguanides, triethyl citrate, 2- amino-2-methyl-1-propanol (AMP), cetyl-trimethylammonium bromide, cetyl-pyridine chloride, famesol (3.7, 11-trimethyl-2,6,10-dodecatrien-l-ol), bactericides, and / or bacteriostats.
    Volatile silicone
    The compositions according to the present invention can include a volatile silicone. In some embodiments, volatile silicone is excluded from the composition. In one embodiment, the volatile silicone is a cyclic volatile polydimethylsiloxane (cyclomethicone), for example, cyclopentasiloxane. By volatile material, it is intended to mean that the material has a measurable vapor pressure at room temperature. Preferably, the cyclic volatile polydimethylsiloxane is cyclomethicone. Various types of cyclomethicone can be used. Illustratively, and not by way of limitation, silicone volatiles are one or more members selected from cyclic polydimethylsiloxanes such as those represented
    11/24 by Formula I:
    ch 3
    --sí — o- | Jfl
    CH 3 where n is an integer with a value from 3 to 7, particularly from 5 to 3. Illustrative examples of suitable cyclomethicone are DC-345 and DC-245, manufactured by Dow Milhoing
    Corporation, Midland, MI. These types include a tetramer (octylmethylcyclotetrasiloxane) and a pentamer (decamethylcyclopentassiloxane). In one embodiment, the amount of volatile silicone in the composition is more than 0 to 40% by weight of the composition. In another embodiment, the amount is less than 40, 35, 30, 25, 20, 15, 10, 5, or 1% by weight of the composition. In one embodiment, there is no volatile silicone in the composition. In another embodiment, there is no silicone in the composition. In another embodiment, the combined amount of vegetable oil and volatile silicone is up to 50, 45, 40, 35, 30, 25, or 20% by weight.
    Baby powder
    In some embodiments, the composition may contain talc. In one embodiment, the amount of talc in the composition is 1 to 10% by weight of the composition,
    Emo li entes
    The composition can contain emollients in any desired amount to obtain a desired emollient effect. Emollients are known in the art and are used to communicate a skin softening effect. Non-volatile emollients are preferred in the present invention. Classes of non-volatile emollients include non-silicone and silicone emollients. Non-volatile, non-silicone emollients include C1-4 alkyl benzoate. The volatile material other than silicone can be a
    12/24 polyethersiloxane, polyalkylarylsiloxane or polyether siloxane copolymer. A non-silicone volatile material illustrative in the present invention is phenyl trimethicone. Non-limiting examples of emollients can be found in U.S. Patent No. 6,007,799. Examples include, but are not limited to, PPG-14 butyl ether, PPG-3 myristyl ether, stearyl alcohol, stearic acid, glyceryl monoricinoleate, isobutyl palmitate, glyceryl monostearate, isocetyl stearate, sulfated tallow, oleyl alcohol, propylene glycol, isopropyl laurate, marten oil, sorbintan stearate, cetyl alcohol, hydrogenated castor oil, stearyl stearate, hydrogenated soy glycerides, isopropyl isostearate, hexyl laurate, dimethyl brassylate, decyl oleate, adipate diisopropyl, n-dibutyl sebacate, diisopropyl sebacate, 2-ethyl hexyl palmitate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, 2-ethyl hexyl palmitate, 2-ethyl hexyl stearate, adipate (adipate) 2-ethyl hexyl)), di (2-ethyl hexyl) succinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, octacosanol, butyl stearate, glyceryl monostearate, glycyl polyethylene cols, oleic acid, triethylene glycol, lanolin, castor oil, acetylated lanolin alcohols, acetylated lanolin, petrolatum, lanolin isopropyl ester, fatty acids, mineral oils, butyl myristate, isostearic acid, palmitic acid, oleic ether PEG-23 , oleyl oleate, isopropyl linoleate, cetyl lactate, lauryl lactate, lauryl lactate, quaternized alkyl hydroxide, aminoglycolate, vegetable oils, isodecyl oleate, isostearyl neopentanoate, myristyl myristate, etearol myristate, myethylate myristate , ethylene glycol monostearate, myristyl stearate, isopropyl lanolate, paraffinic waxes, glycyrrhizic acid, hydroxyethyl starch stearate.
    The composition can additionally include ionizable inorganic salts. These ionizable salts are in the form of M to X b where a = 1, or 2 and b
    13/24 = 1 or 2; M is a chosen member of Na +1 , Li +1 , K +1 , Mg +2 , Ca +2 , Sr +2 , and Zn and X is a chosen member of chloride, bromide, iodide, citrate, gluconate, lactate , glycinate, glutamate, ascorbate, aspartate, nitrate, phosphate, hydrogen phosphate, dihydrogen phosphate, formate, maloneate, maleate, succinate, carbonate, bicarbonate, sulfate, and hydrogen sulfate. In some embodiments, the selected salts are chosen from NaCl and ZnCl 2 . As will be appreciated by those skilled in the art, while it may be possible under certain circumstances to add salt directly to a portion of the mixture during manufacture, it is desired to add the salt as a mixture or solution of the salt in a carrier or solvent, particularly water. Of course, various concentrations of the saline premix can be made.
    The composition may also contain those that include, but are not limited to, talc, mica, fragrance encapsulated, or hydrophobically modified starches, such as aluminum octenyl succinate (MACKADERM® ASTRO-DRY® by Mclntyre Group Ltd.) . If the composition is in a liquid form and is dispensed through a roll-on applicator, the average particle size of the material placed in suspension is measured so that it can pass through the application to prevent the applicator sphere from functioning properly. inadequate. Generally, the average particle size does not exceed 150 microns.
    In some embodiments, the composition may also contain as an optional ingredient at least an odor-neutralizing alpha, unsaturated beta ester or mixtures of such materials. In some embodiments, the level of the bad odor neutralization composition to release a noticeable odor control benefit when released from an antiperspirant and / or deodorant composition is about 0.05 to about 0.45% by weight based on the entire composition. The odor-neutralizing materials of alpha ester, beta-unsaturated are incorporated
    14/24 within the oil phase of an antiperspirant composition. Examples of these components that counter bad odor can be found in U.S. Patent No. 6,610,648 and U.S. Patent No. 6,495,097, which are incorporated herein only for the disclosure of alpha, beta unsaturated esters. For example, in this invention the odor neutralizing alpha ester, unsaturated beta mixture demonstrates unexpected stability in antiperspirant compositions containing low ratios of glycine-free (M: C1) salts. Examples of the alpha, beta unsaturated ester can be found in WO 2005/025523, which was filed in the United States as US Order No. 10 / 571.488, both of which are incorporated herein by reference to the extent that they do not conflict. with the disclosure of this specification.
    Examples of alpha, beta unsaturated esters include, but are not limited to:
    (1) 3-phenyl-2-propenoic acid alkyl esters in which R 1 is a substituent on the benzene ring and is chosen from an alkyl, alkoxy, aryl, or substituted aryl. In some embodiments, R 1 is chosen from H, a C 1 to C 8 alkyl, a C 1 to C 8 alkoxy, or an aryl; and R is a substituent group that replaces hydrogen carboxylic acid to form the ester where R 2 has more than 6 carbon atoms, an aryl, or a substituted aryl group, in some embodiments R 2 is a C6 to C alkyl 22 or is a benzyl group; and (2) a fumaric acid ester or maleic acid having linear carbon ester chains of 3 to 9 carbons, for example, diexyl fumarate;
    (3) e-phenyl propenoic acid ester chosen from octyl methoxy cinnamate, phenylethyl cinnamate, benzyl cinnamate;
    (4) an unsaturated aliphatic ester, such as diexyl fumarate.
    15/24
    The composition can also optionally comprise absorbent materials such as corn starch, talc, clay, sodium polyacrylate and / or cotton fiber; and / or other materials such as fragrances, bacteriostats and / or bacteriosides, dyes, etc. Known bacteriostats include bacteriostatic quaternary ammonium compounds such as 2-amino-2-methyl-1-propanol (AMP), cetyltrimethylammonium bromide, cetyl pyridine chloride, 2,4,4N-trichloro-2Nhydroxydiphenyl ether (Trichosane), etc. and various zinc salts.
    Antioxidants can be added to the composition, preferably to act as protectors of ingredients and to maintain the long-term stability of the composition. Suitable antioxidants include Tinogard, manufactured by Ciba Specialty Chemicals, Basel, Switzerland.
    The compositions as provided herein are described and claimed with reference to their ingredients, as is usual in the art. As would be evident to those skilled in the art, the ingredients may, in some instances, react with each other, so that the true composition of the final formulation may not correspond exactly to the listed ingredients. Thus, it should be understood that the invention extends to the combination product of the listed ingredients.
    The compositions of the present invention can be manufactured using methods known in the art. Typically, the ingredients are combined and heated to melt the components (other than inert filler), and the melted components (together with the inert particulate filler) are mixed. Desirably, volatile materials, such as fragrance materials, are incorporated into the composition at stages after the mixing cycle, in order to avoid their volatilization. After mixing, the molten composition can be poured directly into the dispensers, after
    16/24 compositions are hardened to a solid, and the container is capped to preserve the product until use.
    In one embodiment, the composition is a solid or soft solid stick when at an ambient temperature of about 25 ° C. The stick shape is an example of a solid shape, and the soft solid is a thickened shape that may or may not be solid. The stick shape can be distinguished from a soft solid in which, on a stick, the formulated product can retain its shape for extended periods of time outside the package, the product not significantly losing its shape (allowing for some shrinkage due to solvent evaporation) . Adjusting the amounts of gel forming or thickening agents can be used to form a stick or soft solid.
    The soft solids can be properly packed in containers that look like a stick, but which dispense through openings (for example, grooves or pores) in the top surface of the packaging. Soft solid products have also been called soft sticks or "smooth-ons", and then are generically called "soft solids". Reference is made to U.S. Patent No. 5,102,656, Pat. No. 5,069,897, and U.S. Pat. No. 4,937,069.
    In one embodiment, the composition is an anhydrous stick. By anhydrous, it is intended to mean that no separate water is added, but there may be moisture associated with the materials that are added to the composition. In some embodiments, the amount of water is zero or less than 3, 2, 1, 0.5, or 0.1% by weight of the composition.
    In one embodiment, the compressive strength of the composition is at least 2500 g. In other embodiments, the compressive strength of at least 3000 g, at least 3500 g, at least 4000 g,
    17/24 at least 4500 g, at least about 5000 g, at least 6000 g, at least 7000 g, at least about 8000 g, at least 9000 g. In another embodiment, the compressive strength is 2500 g to 10,000 g.
    In one embodiment, the composition can provide a distribution of about 0.7 to about 0.9g according to the distribution test on the Distribution, Slip, and Scaling Test Machine, which is the machine and method described in WO 2009/045557. In another embodiment, the composition can provide a slip of about 0.8 to about 1.4 g according to the glide test on the Distribution, Slip and Scaling Test Machine. In another embodiment, the composition can provide a scale of less than about 25%. In other embodiments, the scale is less than about 20, about 15, about 10, or about 5%. In other embodiments, the amount of flaking is from about 1 to about 6%.
    The compressive strength of a stick product is measured using a Texture Analyzer Model # TA-ZT21 from Texture Technologies. The compression probe is a 19 mm square termination probe. The antiperspirant stick is removed from the cylinder and placed in a hardness sample container. The stick is positioned such that 2.54 cm (1 inch) of the sample, measured at the end of the dome portion, is exposed for testing. The lid on the hardness vessel is closed and the vessel is positioned so that the slide comes in contact with the midpoint of the exposed sample. The instrument is adjusted to the following parameters:
    Measured force - compression (speed set to 1.0 mm / s)
    Option - RETURN TO START
    Distance - 5.0 mm
    Unit selection - grams.
    The measurements to be recorded are peak force and distance
    18/24 needed to break the baton. The higher the strength reading, the stronger the stick. The greater the distance to break, the more elastic the stick.
    For the rheology of a solid sample, the following procedure is used for the AR-1000 Instrument:
    (i) Preparation of the Instrument.
    Turn on the computer, turn on the air, remove the rheometer cover, thread in geometry, turn on the instrument, turn on the water circulator. Open the rheology software - AR Instrument Control. Under the geometry tab, select the geometry to be used for the test (20 mm soft solid parallel plate). Then, the interval between the geometric and the peltier plate is zeroed from the instrument menu at the top by choosing interval and then zeroing interval. Follow the instructions on the screen to reset the interval. This is a calibration step to accurately measure the distance between the geometry and the plate. Once the interval has been reset, set up the procedure. Under the procedure menu, select new flow and a flow tab will appear on the main screen. Under the flow tab, select conditioning step on the left of the screen. Adjust the temperature to 37 ° C. Then, in the step window, set up a step flow procedure with the following parameters: Temperature (37 ° C); Slope: Shear Stress (Pa); Range (0.1 to 6000 Pa); (Linear) mode; Number of points (600).
    (ii) Sample preparation.
    Place the sample in a stainless steel cutting template. Increase the product until the curved portion of the product has cleaned the end of the template. Use the wire cutter to remove the curved portion of the product, and discard. The cross section of the product should now be at its maximum extent. Increase the product so that the 3 to 4 mm of the product is exposed past the end of the template. Again,
    19/24 use the wire to cut the exposed product, creating a plate with 3 to 4 mm of product thickness. Cut the plate in half by the width so that there are no holes in the thread sample. This is the sample to be tested. Gently place the 3 to 4 mm thick product plate directly on the Peltier plate, being careful to minimize the amount of shear applied to the sample. The sample should be as close to the epicenter of the plate as possible. Set the instrument's range to 1100 microns. While the geometry is being decreased, gently replace the sample so that it is directly under the geometry. This is to ensure that when the geometry and sample come into contact with each other, the sample acquires the entire surface area of the geometry. When the geometry has stopped in the 1100 micron range, use a spatula to level the excess and product from the end of the geometry. Decrease the geometry to 1000 microns. Start the test by pressing the start experiment button.
    (iii) Data analysis
    The instrument is dedicated to increasing the voltage to the geometry, scanning the preset range from 0.1 to 6000 Pa. The software then graphically viscosizes the viscosity in log (variable y) of the sample as a function of the voltage by shear (variable x). To better quantify the rheological characteristics of a sample, look at 3 numbers; static yield voltage, dynamic yield voltage, and delta voltage. The static yield voltage is the voltage at which the instrument can first precisely measure the sample viscosity, that is, the sample data point on the graph. Dynamic stress is the stress at which the viscosity of the sample begins to decrease rapidly. This portion of the curve will have an almost vertical slope. The final number, delta voltage is the difference between the static yield voltage and the dynamic yield voltage.
    20/24
    In another embodiment, the composition is a stick that does not contain an antiperspirant or deodorant active. In this embodiment, the stick can be formulated to be a lip balm, lip stick, or a cosmetic.
    SPECIFIC WAYS TO CARRY OUT THE
    INVENTION
    The invention is also described in the following examples. The examples are illustrative only and do not limit the scope of the invention in any way as described and claimed. Stick compositions are made using the procedures described above. The amounts in the formulas below are in% by weight.
    What follows is a comparative control and two formulations according to the invention. Formula 1 is an example of a stick composition with about 53.4% by weight of silicone replaced with palm seed oil based on the combined amount of silicone and palm seed oil. Formula 2 is an example of a stick composition without any silicone.
    21/24
    Material Control Formula 1 Formula 2 Altju benzoate thi 10 0 16.9 PPG-14 biplane 6 16.65 0 Lihydrogenadu soybean oilIodine value greater than 0 to about 20 ' T 2 Hydraulic oil of hydroxide 1.P0M0 of fusion to S () C> 5 5 5 PEG-Í5 dislcaralo 2 3 3 Stearyl alcohol 16 16 16 Aleool hecnilieo 0.3 5 0.15 0.15 Palm dc oil 0 18.7 35 Aluminite Telraeloridrex <Zirconium ily 20 2" 20 Cyclomethicone 33.9 16.5 0 Baby powder 2 0 0 Fragrance and side effects. the to 100 OS ii 100 OS to 100
    The example below is a demonstration that the composition containing vegetable oil can provide the same level of sweat reduction effectiveness as a product without vegetable oil. In this example, formulas 1 and 2 were compared to the control formula to determine the level of sweat reduction effectiveness. A 3 cell warm room clinical test was conducted. All products were applied in an equivalent dose of 0.5 grams / armpit / application. Eighty-one (81) male volunteers with shaved armpits participated in the study.
    Method • Recruit male panelists, 18 to 55 years old, • Refrain from using A / P and talcum powder for 21 two before the study started, two days before the study, the panelists' armpits were shaved by professional barbers (scraping with foam / razor), • Start the study with a group on Monday and a second group on Tuesday.
    • On day 1, obtain baseline sweat collections following standard hot room procedures for round robin projects, wash underarms, make the first application using a randomized 4-cell test, • On day 2, wash the armpits, perform the second application,
    22/24
    On day 3, wash the armpit, perform the third application,
    On day 4, wash your armpits, perform the fourth application,
    On day 5, collect the sweat 24 hours after # 4,
    Data analysis was performed using the SAS software statistics, data from both groups of panelists were combined for analysis. The results are shown in the table below
    Control Formula 2 Formula Baseline output (g) 1088 11 85 1176 Post-treatment output (g) 1071 1003 1070 Sweat reduction estimated in% 7.7 | 15.0 | 11.2 Corrected average difference i 4 5.7% 3.6% Formula fav 2 Formula fav 2 95% of C.l, for «i average difference (-1.1. 12.9) (-3.1. 10.7) P value 0.0996 0.2938
    Corrected average difference j, 2.0%
    Formula fav I
    Corrected average difference
    2.0%
    Formula fav I% C.l. for the average difference (-4.5. 9.0)
    P-value 0.5481
    Average square hrro 0.0223
    The results of clinical efficacy showed: Control,
    Formula 1, and Formula 2 general performed in statistical equality for each other, p> 0.05, and Formula 1 performed in statistical equality to Formula 2 »p = 0.2938.
    Contrary to what was expected, compositions with natural oils had one. performance equal to a product containing silicone without natural oil.
    Additional formulas which can be made according to the invention are contained below.
    Material rórniLtlrt 3 Formula 4 Formula 5 Formula 6 C12-15 alkyl benzoate 16.65 K.6 | 12.2 10.1 1'-butyl ico PPG-14 0 S.6 j 4.2 6.1 Hydrogenated soybean oil 2 2 2 Iodine value greater than that of Cl to the area of 21> Hydrogenated castor oil t Melting point 80X ') 5 5 5 5 IJistearate of PfXi-8 Λ 3 3 Λ Stearyl alcohol 16 16 16 16.1 Beenyl alcohol 0.15 0.15 0.15 0.15 Demented palm oil 26.7 34.7 30.3 15, « Aluminum Telraeloridrex (ily of Zíreómo 20 20 20 20.2 Cielometieona 8.5 0 4.1 18.4 Baby powder 0 0 1 1 7
    23/24
    IQ Sa 100 [OS at 100 QS a liio [QS at 100 |
    Ten female judges evaluated the sensory properties of the control formula and formulas I to 5, with each pannista evaluating each product twice using an evaluation scale (15-point scale). The samples are shielded and encoded with a random three-digit number. The order of presentation of the sample is balanced and randomized through the panelists. Each panelist tested 2 products per session, one on each arm. Each panelist pre-washed his armpit with soap, and then wiped it off with light taps. They were in an environmental room for 10 minutes, 5 minutes with their arms lowered and 5 minutes with their arms raised to allow air to flow under their arm before applying a specified amount (4 applications) of each sample to their exiles. The panelist evaluated each test product for application, visual, tactile attributes at various time points (for example, 15 minutes after application) including slip, spread uniformity, coolness, hardness, whiteness, thickness, wetting, Quantity Residue, Paraffinic Residue, Fineness, Oily / Fatty Residue. After assessing the armpits, each panelist wiped his armpit with disposable moist paper towels before reapplying the product to the armpit after the application procedure. A sample, 15.2 cm x 17.8 cm (6 ”x 7”) of black cotton fabric, is applied to the armpit. The arm is held against the trunk for 10 seconds, the tissue is removed and evaluated to remove the white residue and other residues by rubbing.
    The table below shows how each formula comparatively performed against the control formula.
    formula 3 ] 2 4 5 1 slide application < < Application of 4 glides < < Basl Hardness > Apiitaçài) rtwiâ < Wet application ..... ..... ...... < Application v i scusii Dcsli / iimètiU application) < < <
    24/24
    Formula 3 1 2 4 5 2 minutes of sliding <: :: r 5 minutes of sliding = e: ;: < = = 15 minutes of sliding > > Whiteness-Aplieation < < = Application of Amt Res < < = = < 2 Minutes from Anil Res < = = < 5 Minutes from Anil Res < < 10 Minutes from Amt Res < ....... < 20 Minutes from Amt Res .... Application Oil / Grease ...... ....... < 2 minutes Res Oil / Grease ...: < ....: 5 minutes Res Oil / Grease < = < 10 minutes Res Olco / Grease =: < < < 20 minutes Res Oil / Grease > > > > 25 minutes Res Oil / Grease > = > > 30 minutes Res Oil / Grease = = > = = 25 minutes powder < < < < < 30 minutes powder < < < < < Prela Clothing: Rub off the white residue < • c ~ < < Other Waste-Clothes < - < - Distribution (g / armpit) = = >
    <; The product had a significantly lower value for that attribute vs. control>: The product had a significantly higher value for that attribute vs, control =; performance equality vs. control
    Below are examples of formulations using other vegetable oils.
    Material THE li G □ C12-15 alkyl benzoate 10.1 10.1 10.1 10.1 Bulier bulilico PPG-14 ή 6 6 6 Hydrogenated soybean oilIodine value more than 0 to about 20 2 2 7 2 Hydrogenated manwn oil (Melting point XO ^ C) 5 5 5 5 PEG-X distearalo 3 3 5 3 .Splastic alcohol 16.1 16.1 16.1 16.1 Beenyl alcohol 0.15 0.15 0.15 0.15 Coconut oil 15, « 0 « 0 High-content sunflower oil 0 15, « « 0 Sunflower oil 0 0 15.X 0 Olive oil (extra-virgin) 0 0 « I5, S Alumino Teiraeloridrex Gly of Zíreõnio 20.2 10.2 20.2 20.2 Cyelomethicone 1 S, 4 18.4 18.4 IX, 4 Baby powder 2 2 7 2 Fragrãneias and Secondaries QS to 10 « QS to 10 « OS to 100 GS »100
    1/5
    权利要求:
    Claims (27)
    [1]
    1. Composition, characterized by the fact that it comprises a mixture product of:
    a) at least one antiperspirant active;
    b) at least one deodorant active, where the deodorant active is at least one material chosen from antimicrobial active, alcohols, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, benzethonium chloride, polyamethylene biguanides, citrate triethyl, 2-amino-2methyl-1-propanol, cetyl-trimethylammonium bromide, cetyl pyridine chloride, famesol (3.7, 11-trimethyl-2,6,10-dodecatrien-l-ol), bactericides, and / or bacteriostats;
    c) more than 10% by weight and less than 50% by weight of vegetable oil; and
    d) a gelling agent;
    where the composition is free from silicone oil and silicone, where vegetable oil comprises a combination of palm seed oil and coconut oil, where the melting point of vegetable oil is less than
    30 ° C, and where the composition is a stick product.
    [2]
    2. Composition according to claim 1, characterized by the fact that it also comprises: non-volatile emollients that are not vegetable oils.
    [3]
    Composition according to claim 1, characterized by the fact that it also comprises: more than 1% by weight and less than 10% by weight of talc.
    [4]
    4. Composition according to claim 1, characterized by the fact that the at least one antiperspirant active
    2/5 comprises one or more betaine-stabilized antiperspirant salts and a calcium salt.
    [5]
    5. Composition according to claim 1, characterized by the fact that the at least one deodorant active comprises one or more of benzethonium chloride, polyamethylene biguanides or triethyl citrate.
    [6]
    6. Composition according to claim 1, characterized in that the composition comprises more than 10% by weight and less than 25% by weight of vegetable oil.
    [7]
    7. Composition according to claim 1, characterized in that the composition comprises more than 10% by weight and less than 20% by weight of vegetable oil.
    [8]
    8. Composition according to claim 1, characterized in that the composition comprises more than 10% by weight and less than 15% by weight of vegetable oil.
    [9]
    9. Composition according to claim 1, characterized by the fact that the vegetable oil comprises at least 86% by weight of saturated Cio-Cis fatty acids.
    [10]
    10. Composition, according to claim 1, characterized by the fact that the composition is an anhydrous stick product.
    [11]
    11. Composition according to claim 1, characterized in that the gelling agent comprises a partially hydrogenated soybean oil having an iodine value greater than or equal to about 75 and less than or equal to about 80.
    [12]
    12. Composition according to claim 1, characterized in that the gelling agent comprises a partially hydrogenated soybean oil comprising more than or equal to 17.5% by weight of saturated Cio-Cis fatty acids and less than or equal to
    3/5
    19.5% by weight of saturated Cio-Cie fatty acids.
    [13]
    13. Composition according to claim 1, characterized by the fact that the stick product has a distribution greater than or equal to about 0.7 grams and less than or equal to about 0.9 grams according to with a distribution test on a distribution, slip, and scale test machine.
    [14]
    14. Composition according to claim 1, characterized by the fact that the stick product has a slip greater than or equal to about 0.8 grams and less than or equal to about 1.4 grams according to with a slip test on a distribution, slip, and scale test machine.
    [15]
    15. Composition, according to claim 1, characterized by the fact that the stick product has a scale greater than or equal to about 1% and less than or equal to about 6% in a test machine. distribution, sliding, and scaling.
    [16]
    16. Composition, characterized by the fact that it comprises a mixture product of:
    a) at least one antiperspirant active;
    b) at least one deodorant active, where the deodorant active is at least one material chosen from antimicrobial active, alcohols, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, benzethonium chloride, polyamethylene biguanides, citrate triethyl, 2-amino-2methyl-1-propanol, cetyl-trimethylammonium bromide, cetyl pyridine chloride, famesol (3.7, 11-trimethyl-2,6,10-dodecatrien-l-ol), bactericides, and / or bacteriostats;
    c) more than 10% by weight and less than 50% by weight of canola oil; and
    d) a gelling agent;
    where the composition is free of silicone oil and
    4/5 silicone, where the melting point of canola oil is less than
    0 ° C, and where the composition is a stick product.
    [17]
    17. Composition according to claim 16, characterized by the fact that it also comprises: non-volatile emollients that are not vegetable oils.
    [18]
    18. Composition according to claim 16, characterized by the fact that it also comprises: more than 1% by weight and less than 10% by weight of talc.
    [19]
    19. Composition according to claim 16, characterized by the fact that the at least one antiperspirant active comprises one or more betaine-stabilized antiperspirant salts and a calcium salt.
    [20]
    20. Composition, according to claim 16, characterized by the fact that the at least one deodorant active comprises one or more of benzethonium chloride, polyiexamethylene biguanides or triethyl citrate.
    [21]
    21. Composition according to claim 16, characterized by the fact that the composition is an anhydrous stick product.
    [22]
    22. Composition, characterized by the fact that it comprises a mixture product of:
    a) at least one antiperspirant active;
    b) at least one deodorant active, where the deodorant active is at least one material chosen from antimicrobial active, alcohols, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, benzethonium chloride, polyamethylene biguanides, citrate triethyl, 2-amino-2methyl-1-propanol, cetyl-trimethylammonium bromide, cetyl pyridine chloride,
    5/5 famesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol), bactericides, and / or bacteriostats;
    c) more than 10% by weight and less than 50% by weight of babassu oil; and
    d) a gelling agent;
    where the composition is free of silicone oil and silicone, where babassu oil comprises at least 50% by weight of C12-C14 fatty acids, and where the composition is a stick product.
    [23]
    23. Composition according to claim 22, characterized by the fact that it also comprises: non-volatile emollients that are not vegetable oils.
    [24]
    24. Composition according to claim 22, characterized in that it also comprises: more than 1% by weight and less than 10% by weight of talc.
    [25]
    25. Composition according to claim 22, characterized in that the at least one antiperspirant active comprises one or more betaine-stabilized antiperspirant salts and a calcium salt.
    [26]
    26. Composition according to claim 22, characterized by the fact that the at least one deodorant active comprises one or more of benzethonium chloride, polyiexamethylene biguanides or triethyl citrate.
    [27]
    27. Composition according to claim 22, characterized by the fact that the composition is an anhydrous stick product.
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    同族专利:
    公开号 | 公开日
    BR112012006665A2|2016-05-03|
    RU2491912C1|2013-09-10|
    AR078195A1|2011-10-19|
    MX2012003029A|2012-04-19|
    ZA201202223B|2014-09-25|
    RU2567054C2|2015-10-27|
    WO2011040911A1|2011-04-07|
    EP2482790B1|2017-09-27|
    US20110076309A1|2011-03-31|
    CA2772709C|2015-07-21|
    CA2772709A1|2011-04-07|
    MX342275B|2016-09-22|
    US11058904B2|2021-07-13|
    EP2482790A1|2012-08-08|
    RU2013119986A|2014-11-10|
    AU2009353312B2|2013-04-04|
    AU2009353312A1|2012-03-22|
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    法律状态:
    2016-09-06| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2016-09-13| B15K| Others concerning applications: alteration of classification|Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61K 8/34 , A61K 8/81 , A61K 8/92 , A61Q 15/00 , A61K 8/36 Ipc: A61K 8/02 (2006.01), A61K 8/891 (2006.01), A61K 8/ |
    2017-01-31| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2017-05-23| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    2017-09-19| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2018-01-16| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|
    优先权:
    申请号 | 申请日 | 专利标题
    PCT/US2009/059003|WO2011040911A1|2009-09-30|2009-09-30|Antiperspirant/deodorant composition|
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