• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Indicator mechanism for an automatic applicator, particularly for insulin. The present invention relates to an indicator mechanism for an automatic applicator, particularly for insulin, or other liquid preparations, and particularly for administration by multiple injection of adjusted doses of a medicine from an interchangeable container, for example for self-administration. insulin application by patients with diabetes; the indication mechanism for an automatic applicator comprising a set of at least two mobile barrels coupled with each other, characterized in that the indication barrel (2) mounted on the actuation barrel (1) contains only marking (2. 1) on the its external surface and be coaxially connected with the nut (3) of the pull - push type control.
    公开号:BR112012001421B1
    申请号:R112012001421-8
    申请日:2010-03-29
    公开日:2020-12-08
    发明作者:Adam STEFANSKI
    申请人:Copernicus Sp. Z O.O.；
    IPC主号:
    专利说明:

    The present invention relates to an indicator mechanism for an automatic applicator, particularly for insulin, or other liquid preparations, and particularly for administration by multiple injection of adjusted doses of a drug from an interchangeable container, for example, for self - application of insulin by diabetic patients.
    European Patent EP 0 338 806 B um (Holman and Marchai) demonstrates a syringe comprising a body, a dose adjustment device in the form of a rotating hood or ring mounted on the body and capable of being moved to a position of the selected adjustment where a bolt is arranged to retain the adjustment device in that adjustment position, the movement of the adjustment device being accompanied by forcing a spring, which, when the force is released, provides the force to expel the adjusted dose, characterized by means arranged to release the force, which cause the adjustment device to return to its original position to drive a plunger through a one-way crimp, to expel the adjusted dose; and by a threaded assembly with a fast - pitch screw capable of transforming the rotation of the adjustment device into a linear piston movement.
    The indicator mechanism in this syringe is designed in such a way that the displacement of the plunger is obtained by using the energy stored in a helical spring, which is rotated, during the preliminary adjustment of the dose to be injected, through the rotation of a cap rotary or ring, which is rotatably mounted on a sleeve having a degree scale on the right end of the “pen” type syringe body. The rotating hood or ring has an inspection window, showing an angle of rotation of said rotating hood or ring, to be read from the scale.
    The main disadvantage of the mechanism is that the scale comprises at most only one complete rotation, which does not guarantee its adequate accuracy.
    Polish Patent Application P 341 395 also demonstrates a syringe for dispensing adjusted doses of a drug from 30 to a cartridge containing the amount of drug sufficient to prepare various doses of treatment, comprising a housing, a piston rod that has no section - circular and an external screw thread, an arrangement for driving a piston rod comprising two elements, that is, piston rod conductors and a nut with an internal screw thread corresponding to the external screw thread 35 of the piston rod, as well as a dose adjustment mechanism comprising a connection with a non-self-locking screw thread, along which an injection push button is unscrewed from the end closest to the housing, causing rotation of the dose adjustment element. . This syringe is characterized by the fact that between the nut and the piston rod conductors there is uni-directional coupling allowing the rotation of both parts in one direction but not in the opposite direction, where the permitted rotation is the only one, by means of which the piston rod is moved towards the circumference in the syringe. The coupling is designed in such a way that the initial resistance, sufficient to resist the torque exerted on the coupling by adjusting a dose, has to be overcome to achieve rotation.
    The indicator mechanism in this syringe is designed in such a way that a convex spiral flap, forming a quick thread, is formed on the inner wall of the second part of the housing. On the outer wall of the dosing barrel, which has a scale, there are spiral grooves that define an external thread that mates with the internal thread of the housing. The pitch of the threads exceeds the friction angle of the materials that form the threaded parts, and therefore the coupling is not self-locking and causes a part of the coupling to rotate when another part is linearly displaced. The numbers that indicate the adjusted doses are printed on the outer wall of the dosing barrel, and indicated in a window located on a side wall of the housing.
    European Patent EP 1 351 732 A 1 (Enggaard Christian) demonstrates a dose adjustment device for use in combination with a fluid filled reservoir, the dose adjustment device being adapted for repetitive injection of individually adjusted doses of fluid from the reservoir, the dose adjustment device comprising: a housing, a drive member adapted to expel a dose of medication from the reservoir, a spring-type means, a dose adjustment assembly mounted on the housing and connected to the spring type means, the dose adjustment assembly comprising a dose adjustment member that moves in a first direction to a selected adjustment position against the derivation of the spring type means, where the movement of the spring member dose adjustment is accompanied by the pressing of the spring, and where the dose adjustment member is movable in a second direction to selectively adjust the chosen dose, a bolt-type medium to ssociated with the housing to hold the apparatus in the adjusted position against the derivation of the spring-like means, and the bolt-like means being releasable to cause the actuating member to expel the adjusted dose from the syringe, the force to expel the adjusted dose being provided by spring-type means.
    The dose adjusting member comprises a more distant end wall and a portion of the shirt disposed from behind. The end wall has an opening with an internal thread, the end wall thereby serving as a second nut-like member through which the plunger is arranged. The thread corresponds to the internal thread, thus allowing the piston to rotate without locking. The end wall further comprises a coupling surface that faces the rear, to be described below. The shirt portion of the dose adjusting member comprises longitudinal grooves on its inner surface by setting corresponding longitudinal tongue-like members on the outer surface of the shirt-like portion of the cuff, thus the two shirt-like members being able to slide in the mode axial but not rotating in relation to each other. In fact, any suitable configuration could be used to provide this functional relationship between the two shirt-like members. Numbers (not shown) are printed along a helical line on the outer surface of the shirt, which can be inspected through a window in the device housing, the window allowing only a portion, preferably only one, of the numbers on the glove to be seen.
    Polish patent application P 375 372 demonstrates an automatic applicator, particularly for insulin, more particularly for the application, by multiple injection, of the adjusted doses of a medicine from an interchangeable container, comprising a housing body connected to a housing of an interchangeable container with a medicine, particularly insulin, expelled by a piston connected to a plunger and linearly displaced by means of a control and locking drive unit activated via a double spring tensioning unit located in the housing body, tensioned by a ring manual dose adjustment rotary also via a double bezel unit where a drive unit for control and locking is activated by a trigger-type unit and where an indicator cylinder that can move is located on the holder of the tension spring. According to the invention, said automatic applicator is characterized by the fact that the double crimping unit comprises a crimping plate coaxially coupled with a toothed plate body and coupled with tabs that have matched fasteners so as to fray with a ring type gear of a drive nut. _. - -
    The dose adjustment mechanism comprises the indicator cylinder, which can move, located on the holder of the tension spring; the mechanism is mounted in a sliding manner, coaxially, in the groove of the tension spring carrier and has a helical groove on its outer surface mated with the internal screw thread of the housing body. Such construction provides the dosage scale, properly shifted in the dose setting, to be clearly visible through a dose adjustment inspection window. In spite of this, the indicator cylinder, which can move, comprises the dose adjustment end indicator in the form of a red dot, collaborating with the opening of the dose adjustment end indicator window, provided with the dose adjustment window. dose adjustment end. The currently adjusted dose can be seen on the indicator cylinder, which can move, with the scale through the opening of the dose adjustment inspection window. The cylinder is staggered in one to one unit, and the rotation of the manual dose adjustment rotary ring is accompanied by a characteristic click sound for each unit, which corresponds to 0.01 ml of insulin. The dose adjustment can be carried out up to a single unit, where the scale, visible through the dose adjustment inspection window, stops at any value, or between the prescribed dose values, as indicated by the dose indicator arrow on the accommodation.
    European Patent Application EP 1 819 382 A 1 by Moller Claus Schmidt and Markussen Tom Hede, demonstrates an injection device, a housing with an internal surface provided with threads, a dose adjustment member adapted to adjust a dose to be injected from the injection device, a torsion spring operatively connected to the dose adjustment member, so that energy is accumulated in the torsion spring under a rotation of the dose adjustment member, having a rotatingly mounted display member in accordance with per-thread mode, with the housing threads and operatively connected with the dose adjustment member, and adapted to show the dose to be injected from the injection device according to an adjustment of the dose adjustment member, the display member rotatably mounted being rotatable at an angle corresponding to at least one revolution of the display member.
    The dose adjustment mechanism of this device comprises the internal surface of the injection device housing provided with threads. These threads are adapted to crimp and co - operate with external threads from a dose indicator barrel. The dose indicator barrel matches the slide portion of the dose adjustment member in such a way that the dose indicator barrel is able to slide on said slide portion in an axial direction of the injection device. When the dose adjustment member is rotated, to adjust a dose, the dose indicator barrel rotates with the dose adjustment member causing the dose indicator barrel to be displaced axially with respect to the housing. A window is provided in the injection device housing. Through this window, the user of the injection device can see the adjustment level of the actual dose from numerals (not shown) provided on an outer surface of the dose indicator barrel. Numerals are arranged along a helical pitch.
    The main disadvantage of known devices is the lack of provision for the precise controlled and adjusted dose of a drug. Previous projects (for example, considering E P 0 338 806) comprise a scale located only on a circumference and make it possible to place only the small size numbered impressions. Also later, discussed above, projects having a spiral scale on the indication barrel did not meet their objectives adequately. Due to the high friction during movement along the thread of the housing wall, the accuracy of the dose adjustment is difficult. Also, due to the cross-thread with the outer wall of the indication barrel, it is not possible to properly place large printouts of indication numerals on it.
    This matters in relation to the recommended applications of the invention, particularly in the case of self - administration of insulin by diabetic users, since diabetes causes significant loss of vision. In such a context, the presence of a thread on the scale constitutes a disadvantage that is important, since, which, it makes it difficult to read the size of a dose. Magnifying glasses and lenses used in inspection windows deform the read numerals and do not provide a satisfactory solution to this problem.
    Also, the thread that occupies the surface area intended for the scale reduces the number of numerals that can be placed there. The extension of the scale to compensate for the loss of surface area due to the thread leads to the excessive extension of the entire application device, making it poorly maneuverable or even unsuitable for its use. A scale should, of course, be readable, but compact.
    The existence of threads is also a significant technical obstacle because there is a need to place the prints of numerals only between threads, that is, along a helical line. This makes it difficult to locate important marks for the user, for example, the mark that indicates the end of insulin administration at the most advantageous position on the scale.
    The main target of the present invention, referring to an indicator mechanism for an automatic applicator, particularly for insulin or other liquid preparations, particularly for administration by multiple injection of adjusted doses of a medicine from an interchangeable container, is to guarantee a capacity for precisely controlled adjustment and indication of an adjusted dose of a drug, preserving automatic administration of the drug without any effort and without any loss of drug, such as reflux formed while adjusting the dose, particularly by minimizing internal friction forces of the mechanism.
    The second aim of the invention is to ensure an ability to adequately deposit large impressions on the scale, in any numbers and with any configuration of signs and indication numerals, by removing the surface of the indication barrel from any elements that restrict its area .
    The third aim of the present invention is to provide a suitable indication mechanism for an applicator with the possible number of doses to be adjusted in greater numbers than in known devices of such type.
    The main objectives of the present invention were achieved by the automatic applicator present for liquid pharmaceutical preparations, particularly for insulin.
    An indicator mechanism for an automatic applicator, particularly for insulin, or other liquid preparations, particularly for administration by multiple injection of adjusted doses of a medicine from an interchangeable container, comprising a set of at least two barrels movably coupled with each other according to the present invention, it is characterized by the fact that the indication barrel mounted on the actuation barrel contains only marking on its external surface, and is coaxially connected with the pull - type control nut.
    Advantageously, the indication barrel is mounted in a sliding manner, coaxially, and along the actuation barrel by means of a key-type coupling, advantageously a keyed-type coupling with splints comprising the grooves and keys , most advantageously a keyed type coupling with splints comprising bayonet keys.
    Advantageously, the indication barrel is slidably mounted between its two end positions defining the working range of the indication barrel.
    Advantageously, the drive barrel is also rotatably mounted.
    Advantageously, the pull - push type control nut is rotatably mounted on the drive barrel by means of a threaded coupling, advantageously having a non - self - locking thread.
    Advantageously, the pull - push type control nut is mounted slidingly, coaxially, and along the applicator housing by means of a key - type coupling, advantageously a keyed - type coupling with splints.
    Advantageously, the indication barrel is mounted along with the pull-push control nut by means of a gripping unit, advantageously a circumference type grasping unit comprising the indication barrel grip and the nut grip of control.
    Advantageously, the indication barrel is mounted on the actuation barrel with its outer surface located at the defined distance from the inner surface of the applicator housing.
    Advantageously, the indication marking on the outer surface of the indication barrel is in the form of indication numerals deposited in a spiral.
    Advantageously, the drive barrel is connected to a drive element in the form of resilient means, advantageously in the form of a helical spring.
    Advantageously, the actuation barrel is connected to a mechanism for adjusting the dose of medication.
    The present invention was presented in detail, in the advantageous examples of its configuration, in the drawings, where: - Figure 1 shows the frontal axometric view of the indicator mechanism mounted for an automatic applicator, with parts of the housings removed; - Figure 2 shows the longitudinal half - section of the indication mechanism; - Figure 2 A shows the cross section A - A of the indicator mechanism for an automatic applicator; - Figure 2 B shows the cross section B - B of the indicator mechanism for an automatic applicator; - Figure 2 C shows the longitudinal section C - C of the indicator mechanism for an automatic applicator; - Figure 3 shows the cross section D - D of the indicator mechanism for an automatic applicator, displaced by the angle of 45 degrees from the position shown in the longitudinal section C - C; - Figure 4 shows the exploded axiometric side view of the indicator mechanism for an automatic applicator, with parts of the housings removed; and - Figure 5 shows the automatic applicator with the indicator mechanism according to the present invention.
    As shown in fig. 1, the indication mechanism for an automatic applicator for liquid pharmaceutical preparations, particularly for insulin, more particularly for administration by multiple injection of adjusted doses of a medicine from an interchangeable container, comprises a set of steel minus two barrels movably coupled with each other, where the indication barrel (2) mounted on the actuation barrel (1) contains marking (2. 1) only on its outer surface and is coaxially connected with the control nut (3) pull - push type. The mechanism as a whole is arranged in the housing (4). As shown in figs. 1, fig. 2, fig. 2 A, fig. 2 B, fig. 2 C, fig. 3, and fig. 4, the indication barrel 35 (2) is mounted slidingly, coaxially, and along the actuation barrel (1) by means of a keyed type coupling with splints here comprising the grooves (1 2) the driving barrel (1) and the keys (2. 2) of the indication barrel (2), where the keys (2. 2) are bayonet type keys.
    The indication barrel (2) is slidably mounted between its two end positions defining the working range of the indication barrel (2). The drive barrel (1) is rotationally mounted. The pull-push control nut (3) is rotatably mounted on the drive barrel (1) by means of a threaded coupling comprising the groove (1.1) with the drive barrel thread (1) and the flap (3. 2) with internal thread of the control nut (3), advantageously having non-self-locking thread. The pull-push control nut (3) is mounted slidingly, coaxially, and along the housing (4) of the applicator by means of a keyed type coupling with splints, advantageously the coupling of the keyed type with splints comprising the grooves (4.1) of the housing (4) and the keys (3.1) of the control nut (3).
    The indication barrel (2) is mounted along the pull-push control nut (3) by means of a grip unit, advantageously a circumference grip unit comprising the grip (2. 3) of the indication barrel (2) and the grip (3. 3) of the control nut (3). The indication barrel (2) is mounted on the actuation barrel (1) with its external surface located at the defined distance from the internal surface of the housing (4) of the applicator, where the housing (4) comprises the inspection window (4 . two). The indication marking (2.1) on the outer surface of the indication barrel (2) is here in the form of indication numerals deposited in a spiral. The drive barrel (1) is connected to a drive element in the form of elastic (resilient) means, here in the form of the helical spring (5) - fig. 5.
    As shown in fig. 5, the actuation barrel (1) is connected to a mechanism for adjusting the dose of medication in the form of a joint comprising the handle (8) for turning, the grip (6), the resilient element, here being the spring ( 5) helical, the spring-type element block (7), the plunger (11), the toothed mechanism (12), the nut (13), the piston locking sleeve (14), the block (10 ) of the plunger, the trigger (9) and the housing (15) of the container.
    The indicator mechanism, for an automatic applicator for liquid pharmaceutical preparations, particularly for insulin, more particularly for administration, by multiple injection, of adjusted doses of a drug from an interchangeable container, operates as follows.
    When a dose must be adjusted, the actuation barrel (1) is rotated clockwise, looking in the direction of the needle (ascending adjustment), or counterclockwise (adjustment correction), where the control nut (3) is moved along the actuation barrel (1) by means of the threaded coupling comprising the flap (3.2) with internal thread of the control nut (3) moving in the groove (1.1) with thread made on the outer wall of the cylindrical drive barrel (1). The pull-push control nut (3) is secured against rotation by means of the keys (3.1), which are moved coaxially in the corresponding grooves (4.1) made in the internal cylindrical wall the housing (4). Such connection allows the preservation of increased clearance between the external cylinder of the control nut (3) and the internal cylindrical wall of the housing (4), which contributes to the elimination of friction between these two cylindrical parts, which is much less thanks to to the coaxial sliding movement of the keys (3. 1) in the grooves (4. 1), keeping the indicator mechanism at the central point of rotation by means of the forces indicated by the arrows in fig. 2 B.
    The control nut (3) while moving along the housing (4) pulls behind you (during increasing adjustment) or pushes in the opposite direction (during adjustment correction) the indication barrel (2) by means of the grip (3. 3) of the control nut of the control nut (3) connected for rotation to the corresponding grip (2. 3) of the indication barrel of the indication barrel (2). The indication barrel (2) executes the resulting movement, while it is pulled or pushed by the control nut (3) in the coaxial direction and simultaneously rotates together with the actuation barrel (1) since it is coupled with it through its keys (2. 2) and the grooves (1. 2) on the outer wall of the cylindrical drive barrel (1). This connection makes it possible to preserve the increased clearance between the external cylinder of the driving barrel (1) and the internal cylindrical wall of the indicating barrel (2), which contributes to the elimination of friction between these two cylindrical parts, which is much less thanks to the coaxial sliding movement of the keys (2. 2) in the grooves (1. 2), keeping the indicator mechanism at the central point of rotation by means of the forces indicated by arrows in fig. 2 A and fig. 2 B. The resulting movement of the indicating barrel (2) is a spiral movement against the inspection window (4. 2) in the housing (4), which allows any number of complete rotations of the indicating barrel (2) against the housing (4) within the displacement range of the indicating barrel (2) against the driving barrel (1).
    It is to be emphasized that the direction of rotation can thus be changed, such an enlarged adjustment is obtained by turning the actuation barrel (1) counterclockwise. In such a configuration the decreased adjustment can be obtained by turning the actuation barrel (1) clockwise.
    The construction of the present indicator mechanism for an automatic applicator is based on the principle of collaboration of cylinders joined by couplings of the keyed type in such a way that there is no friction between the cylindrical surfaces of the elements. Thanks to this, the forces of the other, actuating and / or elastic elements, may be less, which leads to a more uniform operation of an applicator during the dose adjustment and dose administration process. The ideal axial alignment of the collaborating elements, guaranteed by means of keyed couplings, positively affects the precision of medication administration, which eliminates the formation of reflux while adjusting the dose by decreasing the dose to actually be administered , and enabling the dose to be administered to be exactly as prescribed.
    Essential for the present invention is the triple coupling of the indication elements of an automatic applicator, that is, the mutual cooperation of the indication barrel (2) with the driving barrel (1) and with the control nut (3) in the mode which allows the precise and controlled decrease of the incorrectly adjusted dose, preserving an automatic administration of the medication without any effort, guaranteeing a long-term use of the automatic applicator, particularly for insulin, and more particularly for administration by multiple injection of adjusted doses of a medicine from an interchangeable container.
    权利要求:
    Claims (10)
    [0001]
    1. Indicator mechanism for an automatic applicator, particularly for insulin, or other liquid preparations, and particularly for administration, by multiple injection, of adjusted doses of a medicine from an interchangeable container, comprising an applicator housing, a set of steel at least two movable barrels coupled with each other, where the indication barrel (2) mounted on the actuation barrel (1), directly inside the applicator housing (4), contains only one indication marking (2. 1) on its external surface, the indication barrel (2), which contains only the indication marking (2. 1) on its smooth external surface, be mounted only in a sliding way, coaxially and along, using a key coupling, directly on the external surface of the separate driving barrel (1), without touching the internal surface of the applicator housing (4) and being on its distal end, coaxially and directly, with connected to the separate pull-push control nut (3), located close to it, characterized by the fact that the pull-push control nut (3) is rotationally mounted, by means of a threaded coupling on the driving barrel (1), be mounted in a sliding manner, coaxially, and at length, in the applicator housing (4) by means of a key-type coupling, in which the indication barrel (2) to be pulled or pushed by the pull-type control nut (3) pushes, axially and along, along the actuation barrel (1), where the indication barrel (2) works only to indicate the adjusted dose and to be separated, in the functional mode, the dose adjustment mechanism.
    [0002]
    2. Mechanism according to claim 1, characterized in that the indicating barrel (2) is mounted by means of a key-type coupling, comprising the grooves (1. 2) and the keys (2. 2).
    [0003]
    3. Mechanism, according to claim 2, characterized by the fact that the keys (2. 2) are a keyed type coupling with splints comprising bayonet keys.
    [0004]
    4. Mechanism according to claim 2, characterized by the fact that the indication barrel (2) is slidably mounted between its two end positions that define the working range of the indication barrel (2).
    [0005]
    5. Mechanism, according to claim 1, characterized by the fact that the pull-push control nut (3) is mounted on the drive barrel (1) by means of a threaded coupling, with the thread not of the type self - locking.
    [0006]
    6. Mechanism according to claim 1, characterized by the fact that the indicating barrel (2) is mounted along the length on the pull-push control nut (3) by means of a gripping unit, advantageously a unit a grip of the type of a circumference comprising the grip (2. 3) of the indication barrel and the grip (3. 3) of the control nut.
    [0007]
    7. Mechanism, according to claim 1, characterized by the fact that the indication barrel (2) is mounted on the actuation barrel (1) with its outer surface located at the pre-defined distance, greater than zero, from the inner surface the housing (4) of the applicator.
    [0008]
    8. Mechanism, according to claim 1, characterized by the fact that the marking (2.1) of indication on the external surface of the indication barrel (2) is in the form of indication numerals deposited in a spiral.
    [0009]
    9. Mechanism according to claim 1, characterized in that the actuation barrel (1) is connected to a actuation element in the form of resilient means, advantageously in the form of a helical spring (5).
    [0010]
    10. Mechanism, according to claim 1, characterized by the fact that the actuation barrel (1) is connected to a mechanism for adjusting the dose of medication.
    类似技术:
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    法律状态:
    2019-01-15| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-07-02| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|
    2019-12-24| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2020-08-11| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-12-08| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
    2021-06-22| B16C| Correction of notification of the grant|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/03/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
    优先权:
    申请号 | 申请日 | 专利标题
    PLP388694|2009-07-31|
    PL388694A|PL214940B1|2009-07-31|2009-07-31|Indication mechanism of an automatic applicator, especially for insulin|
    PCT/EP2010/054125|WO2010089417A2|2009-07-31|2010-03-29|An indication mechanism for an automatic applicator, particularly for insulin|
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