• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Preconnected multilayer film (1) for covering a bone defect (2), in particular in the region of a jawbone, wherein the film (1) has a shaping shaping layer (3) for forming the film (1) against the bone defect (2) and at least one covering layer (2). 4, 4a, 4b) for covering the bone defect site (2), wherein the mold layer (3) and the at least one cover layer (4, 4a, 4b) are substantially completely resorbable.
    公开号:AT515384A1
    申请号:T84/2014
    申请日:2014-02-05
    公开日:2015-08-15
    发明作者:Dietmar Dr Sonnleitner
    申请人:Dietmar Dr Sonnleitner；
    IPC主号:
    专利说明:

    The invention relates to a preconnected multilayer film for covering a bone defect site, in particular in the region of a jawbone.
    Known foils or membranes for covering bone defect sites are used, for example, in the area of jawbone for jaw augmentation to rebuild a jaw bone in the case of bone loss or bone loss that may occur in the extraction of a tooth or as a result of an inflammatory process around a natural tooth. Such films often have a Fomnstruktur of titanium, which is arranged on a Teflon membrane and which is integrally formed via the bone defect, so that between the film and bone defect site creates a cavity in the bone material and grow back in natural teeth and the periodontium apparatus. The attachment of the film is usually carried out with resorbable or metal pins or screws that are attached through the film to the jawbone. Alternatively, the film can also be glued to the substrate or to the jawbone. With simultaneously introduced implants, the film can also be attached to the implant head. Since the bone regeneration takes several months, a second operation is necessary after bone formation with a Teflon membrane in order to remove the foil or Teflon membrane from the body again.
    The object of the invention is to avoid the disadvantages described above and to provide a comparison with the prior art improved pre-bonded multilayer film. In particular, a further operation to remove the film should be avoided.
    This object is achieved by the features of claim 1. Advantageous embodiments of the invention are specified in the dependent claims.
    According to the invention, it is thus provided that the film comprises a shaping mold layer for molding the film to the bone defect site and at least one cover layer for covering the bone defect site, wherein the mold layer and the at least one cover layer are substantially completely resorbable.
    By virtue of the fact that the film or membrane as a whole is completely resorbable in the body, for example by being degraded by hydrolysis in the body, it is not necessary to carry out another operation for removing the film. In other words, here only an operation for attaching the film is required.
    The film comprises a shaping shaping layer which serves to mold the film to the bone defect site and through which a cavity can be formed between the bone defect site and the film so that bone growth can take place in this cavity. For favorable bone regeneration, the lumen can also contain bone replacement materials and / or carriers for medicaments, growth factors, and / or other substances that promote and protect healing and bone formation. The cavity is maintained by the space-forming and space-retaining mold layer until the cavity is filled by renewable bone Materiai.
    In addition, the film comprises at least one cover layer for covering the bone defect site. This cover layer, which may be formed, for example, as a membrane, serves to cover and seal the bone defect site in order to prevent the penetration of soft tissue into the bone defect site. In order to further improve the attachment of the film and the sealing of the bone defect site, the at least one cover layer can also be designed so that it adheres to a gum surrounding the bone defect site.
    The fact that the shaping mold layer and the at least one cover layer is provided as an already pre-bonded multilayer film results in an easily handleable film for covering a bone defect which combines the space-forming properties of the mold layer with the sealing properties of the cover layer and which furthermore in the body Essentially completely resorbed. The individual layers of the proposed film (molding layer and at least one cover layer) may be joined together mechanically and / or chemically. Thus, it can preferably be provided that the mold layer and the at least one cover layer are mechanically and / or chemically connected to one another.
    According to a preferred embodiment it can be provided that the mold layer and the at least one cover layer are substantially completely absorbable at different time intervals. For example, by designing the molding layer and the at least one cover layer, it can be achieved that the molding layer absorbs faster than the at least one covering layer. In general, great differences in the resiliency of the molding layer and the at least one cover layer result in great freedom in the design of the film with respect to its absorbability.
    It can be provided that the film as a whole in a period of about 3 to 12 months, preferably about 4 to 6 months, is substantially completely absorbable. This is the period of time within which bone reconstruction usually takes place.
    In order to allow a good Anformung at the bone defect site and a stable cavitation between the film and bone defect site, it can be provided that the mold layer is stiffer than the at least one cover layer is formed. The higher stiffness of the mold layer serves to form a cavity for the bone structure and to maintain this cavity for the period required for bone regeneration upright. By virtue of the lower rigidity of the at least one cover layer compared with the molding layer, good coverage and sealing of the bone defect site can once again be achieved.
    It can preferably be provided that the mold layer, if appropriate together with the at least one cover layer, is formed mechanically and / or thermally and / or chemically deformable. Thus, in particular, the mold layer may be formed as a substantially dimensionally stable layer which can be deformed under mechanical, thermal or chemical influence and in turn has sufficient dimensional stability after this deformation in order to maintain the cavity to be formed for bone growth for the required period of time. The at least one cover layer may be flexible and preferably elastic to allow good coverage and sealing of the bone defect site.
    A mechanical deformation can be done for example by bending with a pair of pliers. This is a suitable method of molding especially for relatively thin mold layers (e.g., in the range of about 0.10 mm to about 0.5 mm). For thicker mold layers (e.g., thicker than about 0.5 mm), thermal deformation of a mold layer for molding may be desirable. A corresponding thermal deformation can be achieved, for example, by means of a thermostable with a hot tip or surface, over heated prefabricated models or in a hot water bath with sterile saline solution. For a good absorbability of the proposed film it can be provided that the at least one cover layer at least partially, preferably substantially completely, consists of a bioresorbable collagen material. It may be provided that the bioresorbable collagen material comprises type I collagen and / or type III collagen. The collagen material may be derived from, for example, bovine Achilles tendons. For a good resorbability of the proposed film can also be provided that the mold layer at least partially, preferably substantially completely, consists of a bioresorbable polymer material. The bioresorbable polymeric material may also be a co-polymer material.
    A particular embodiment provides that the bioresorbable polymer material comprises lactic acid, preferably L-lactic acid, and / or derivatives thereof. It is advantageous if the proportion of lactic acid in the bioresorbable polymer material is at least 70%, preferably about 80% to 95%, particularly preferably substantially 82%.
    In addition, it can be provided that the bioresorbable polymer material comprises glycolic acid. It is advantageous if the proportion of glycolic acid in the bioresorbable polymer material is at most 30%, preferably about 15% to 20%, particularly preferably substantially about 18%. Depending on the composition of the mold layer can be achieved that the mold layer is substantially dimensionally stable and yet substantially completely absorbable.
    In a further preferred embodiment, it can be provided that the mold layer and the at least one cover layer have different area expansions. It can be provided that the mold layer occupies a smaller surface area than the at least one cover layer. If the at least one covering layer covers the shaping layer due to its smaller areal extent, a particularly good covering and thus also sealing of the bone defect site can be achieved.
    It can preferably be provided that the at least one covering layer and / or the shaping layer is or are formed substantially continuous over the entire surface. A favorable for the Anformung to the bone defect site contour of the film can be achieved for example by appropriately cutting the film.
    However, it is particularly favorable if the shaping layer has a shaped structure for molding onto the bone defect site. It can be provided that the shape structure at least partially a convex and / or concave curved edge and / or at least partially has a convex and / or concave curved shape. In other words, the shape structure can have, for example, flat projections-convex and / or concave-and thus have a convexly and / or concavely curved edge.
    Alternatively or additionally, the shape structure as a whole may have a correspondingly convex and / or concave curved shape.
    It is particularly advantageous if the mold structure has at least one strut-shaped molding element. The strut-shaped or flap-shaped Anformelemente can be shaped like a bow over the bone defect site and allow any cavity shape.
    Particularly advantageous is that embodiment of the invention in which the mold structure is formed substantially gitterfönmig. The lattice-shaped mold structure in this case forms a reinforcing grid which allows the formation of a variety of arbitrary cavity shapes.
    It can also be provided that the mold structure is formed by at least one reinforcement of the mold layer. In particular, when the mold layer is applied in the form of a hardening liquid or a hardening gel on the at least one cover layer, it is favorable if the mold structure can be achieved only by the application of more liquid or gel in the region of the mold structure. In this case, for example, the mold layer may have different thicknesses.
    A particular embodiment provides that the film has a carrier layer for at least one substance to be arranged or arranged thereon. The substances to be arranged or arranged on the carrier layer may be medicaments, growth factors and / or other substances which promote and protect healing and bone formation. The carrier layer may preferably be arranged on a side of the foil facing the bone defect site and consist at least partially, preferably substantially completely, of a bioresorbable collagen material.
    It can also be provided that corresponding substances are applied directly to the mold layer and / or the at least one cover layer. It can also be provided that the side facing a bone defect site or
    Surface of the film itself serves as a carrier for the substances described above, for example, by this side or surface of the film has a corresponding roughness.
    Depending on the application, the proposed film or membrane can also be provided precut and / or preformed. In this case, for example, a desired cut and / or a desired 3D deformation of the film can take place according to a data processing-based planning.
    Further details and advantages of the present invention will be explained with reference to the following description of the figures. Showing:
    1 shows an exemplary embodiment of the proposed pre-bonded multilayer film in an exploded perspective view; FIG. 2 shows a side view of the proposed pre-joined multilayer film according to FIG. 1;
    FIGS. 3-7 are plan views of various embodiments of the proposed pre-bonded multilayer film;
    8-15: several embodiments of the proposed preconnected multilayer film in perspective exploded views,
    FIG. 16 shows a proposed convex multilayer film arranged at a bone defect site of a jawbone, FIG.
    FIG. 17 shows a proposed preconnected multilayer film arranged at a bone defect site of a jaw bone with an implant, FIG.
    FIG. 18 shows a proposed preconnected multilayer film arranged at a bone defect site of a jaw bone with implant, washer and posts, FIG.
    19 shows a proposed pre-bonded multilayer film clamped in a groove of a washer,
    FIG. 20 shows a proposed preconnected multilayer film clamped in a groove of a washer and arranged at a bone defect site of a jaw bone with implant and post, FIG.
    Fig. 21: a proposed conjugate multilayer film placed at a bone defect site around a natural tooth; and Fig. 22: a proposed pre-bonded multilayer film arranged at a bone defect site around a natural tooth in a sectional view.
    1 shows an exploded perspective view of a proposed pre-bonded multilayer film 1. The film 1 comprises a mold layer 3 and two cover layers 4a and 4b. The mold layer 3 is stiffer than the cover layers 4a and 4b and has a mold structure 5. The mold structure 5 comprises a plurality of strut-shaped molding elements 7, which serve to form the film 1 via a bone defect 2 (not shown here), wherein the film 1 by the Anformelemente 7 well on a remaining bone 11 of the bone defect site 2 (see, eg FIG. 16). Overall, the mold structure 5 is substantially lattice-shaped and thus allows the formation of any surface shapes of the film 1, so that any cavity forms between the film 1 and the bone defect 2 can be formed in conjunction with a bone defect 2.
    The mold layer 3 and the cover layers 4a and 4b each consist of a bioresorbable material, so that the film 1 as a whole is completely completely absorbable in the body. By providing two cover layers 4a and 4b, between which the mold layer 3 is embedded, in particular the absorption rate and mechanical strength of the mold layer 3 can be controlled.
    The cover layers 4a and 4b may be, for example, bioresorbable collagen membranes which on the one hand can cover a bone defect site 2 well by their softness and on the other hand can bond well with a gum 13 surrounding the bone defect site 2, so that a good sealing of the bone defect site 2 results.
    The mold layer 3 may consist, for example, of a bioresorbable polymer material or co-polymer material. In particular, the mold layer 3 may comprise, for example, about 82% L-lactic acid and about 18% glycolic acid. Such a choice of material results in a substantially dimensionally stable mold layer 3, which may be formed mechanically, thermally and / or chemically deformable for forming on a bone defect 2, wherein the mold layer 3 is substantially dimensionally stable again after such a deformation. Due to the rigidity and dimensional stability of the mold layer 3, a cavity for bone regeneration can thus be created between the film 1 and a bone defect 2 and held for the period of bone regeneration.
    FIG. 2 shows a side view of the pre-bonded multilayer film 1 according to FIG. 1.
    FIG. 3 shows a plan view of a further variant of the proposed film 1, which in this example has two layers and comprises a mold layer 3 and a cover layer 4. Both the mold layer 3 and the cover layer 4 are formed substantially flat. The film 1 can be cut to any desired, depending on the application to allow a good Anformung to a bone defect site 2.
    FIG. 4 and FIG. 5 show two further embodiments of a proposed two-layer film 1 with different outer contours of the cover layer 4 and differently shaped mold structures 5 of the molding layer 3.
    Figure 6 and Figure 7 show further examples of proposed films 1, wherein in the examples shown here, the mold layer 3 was applied in each case as a gel on the cover layer 4 and cured thereafter. The mold layers 3 shown here each comprise a mold structure 5 which has been achieved, for example, by applying more gel in the regions of the mold structure 5 so that the mold layers 3 have different layer thicknesses. In the region of a mold structure 5, a mold layer 3 has a thicker layer thickness than in the remaining regions of the mold layer 3.
    Figure 8 to Figure 15 show further embodiments of a proposed film 1 in each case exploded perspective view. The side 9 of a film 1 pointing downwards in the figures is the side 9 of the film 1 facing a bone defect 2.
    The examples of Figure 8 and Figure 9 are constructed in two layers and each comprise a mold layer 3 and a cover layer 4, wherein the mold layer 3 assumes a smaller surface area than the cover layer 4. The examples of FIG. 10 and FIG. 11 are constructed in three layers and each comprise, in addition to a mold layer 3 and a cover layer 4, a carrier layer 8 on which substances such as medicaments, growth factors and / or other substances promoting healing and bone formation and protective substances may be applied.
    The examples of FIGS. 12 to 15 each have a mold layer 3 and in each case two cover layers 4a and 4b, wherein the mold layer 3 assumes a smaller surface extent than the cover layers 4a and 4b. The examples of FIGS. 13 to 15 additionally each have a carrier layer 8 which can be equipped with corresponding substances (as described above for FIG. 10 and FIG. 11).
    FIG. 16 shows a sectional view of a jaw bone 11 with a bone defect site 2. In order to facilitate bone formation at the bone defect site 2, a proposed pre-bonded multilayer film 1 is correspondingly formed over the bone defect site 2 and anchored to the jawbone 11 by means of appropriate fastening devices 12. The fastening devices 12 may be absorbable nails, for example. Bone replacement materials and / or carriers for medicaments, growth factors and / or other healing and bone formation and forming a periodontal apparatus to natural teeth promoting and protective substances may be included in the forming cavity 10 between the film 1 and bone defect site 2 or jaw bone 11, the bone regeneration to promote. After attachment of the film 1, the previously removed or folded back gum 13 is covered again over the film 1 and sewn accordingly. Due to the resorbability of the film 1 and the fastening devices 12, no further operation is necessary to remove the film 1 and / or the fastening devices 12 after completion of the bone reconstruction.
    FIG. 17 shows a bone defect 2 similar to that of FIG. 16 covered with a proposed foil 1. In this example, an implant 14 was used in the remaining jaw bone 11, the free end is equipped with a screw 15. For easier accessibility to the implant 14 or its screw 15 may be provided in this case that the film 1 is already provided with a pre-punched hole through which the screw 15 can protrude.
    FIG. 18 shows a further example of a bone defect 2 which is covered by a proposed foil 1. In the jawbone 11 an implant 14 is already used, at the free end of a post 16 is arranged. The post 16 projects through both the film 1 and the gum 13 to facilitate further tooth construction. Between post 16 and slide 1, a washer 18 is additionally arranged. Through this washer 18, a closure or a seal of the film 1 in that region of the film 1 can be achieved, through which the post 16 penetrates through the film 1 (penetration area). On the one hand, this is important in order to seal the film 1 against the oral cavity and thus to inhibit the development of inflammation. On the other hand, it can also be achieved that the film 1 absorbs more slowly in precisely this sensitive penetration area and thus can better protect this area. The washer 18 may consist of titanium and project radially beyond the implant 14. The shape of the washer 18 may be, for example, round or oval. The washer 18 can also be designed to be cut to be able, depending on the application, to bring about an optimal closure of the penetration area through the film 1 or to stabilize the sensitive defective area around the implant 14. In this case, the washer 18 can also be made so that the film 1 can be clamped in a groove of the washer 18 as needed and pressed to achieve stabilization.
    Fig. 19 shows a film 1, which is clamped in a groove of a washer 18 and pressed and Fig. 20 shows the arrangement of this film 1 at a bone defect site 2. In the example shown, the upper end of the implant 14 (implant head) projects beyond the jawbone 11 not, but is below the bone level. Depending on how deep the upper end of the implant 14 is located in the jawbone 11 or how large the difference in level between the implant head and bone level can be compensated by differently high inserts 19, so that the film 1 or washer 18 are fixed without cratering can. FIG. 21 shows an example of a bone defect 2 around a natural tooth 17 covered with a proposed foil 1. In this example, it is the application of the proposed film 1 to cover a periodontal Konchendefektstelle 2. The covered by the film 1 sections of the jaw bone 11 and the tooth 17 are shown in broken lines.
    FIG. 22 shows a sectional view of a jaw bone 11 with a bone defect site 2 around a natural tooth 17. In order to enable a bone structure and / or a structure of the periodontium apparatus at the bone defect site 2, a proposed pre-bonded multilayer film 1 is passed over the bone defect site 2 and the tooth 17 molded accordingly and anchored by means of appropriate fasteners 12 on the jaw bone 11. The fastening devices 12 may be absorbable nails, for example. Bone replacement materials and / or carriers for medicaments, growth factors and / or other healing and bone formation and forming a periodontal apparatus to natural teeth promoting and protective substances may be included in the forming cavity 10 between the film 1 and bone defect site 2 or jaw bone 11, the bone regeneration to promote. After attachment of the film 1, the previously removed or folded back gum 13 is covered again over the film 1 and sewn accordingly. Due to the resorbability of the film 1 and the fastening devices 12, no further operation is necessary to remove the film 1 and / or the fastening devices 12 after completion of the bone reconstruction.
    Innsbruck, on February 5, 2014
    权利要求:
    Claims (22)
    [1]
    1. Vorvergede multilayer film (1) for covering a bone defect (2), in particular in the region of a jawbone, characterized in that the film (1) a shaping mold layer (3) for forming the film (1) to the bone defect site ( 2) and at least one covering layer (4, 4a, 4b) for covering the bone defect site (2), the molding layer (3) and the at least one covering layer (4, 4a, 4b) being substantially completely absorbable,
    [2]
    2. Pre-bonded multilayer film (1) according to claim 1, characterized in that the mold layer (3) and the at least one cover layer (4,4a, 4b) are mechanically and / or chemically bonded together.
    [3]
    3. Pre-bonded multilayer film (1) according to claim 1 or 2, characterized in that the mold layer (3) and the at least one cover layer (4, 4a, 4b) are substantially completely absorbable in different periods of time.
    [4]
    4. Vorverbundene multilayer film (1) according to any one of claims 1 to 3, characterized in that the film (1) over a total period of about 3 to 12 months, preferably about 4 to 6 months, is substantially completely absorbable.
    [5]
    5. Pre-bonded multilayer film (1) according to one of claims 1 to 4, characterized in that the mold layer (3) is stiffer than the at least one cover layer (4) is formed.
    [6]
    6. Pre-bonded multilayer film (1) according to any one of claims 1 to $, characterized in that the mold layer (3), optionally together with the at least one cover layer (4,4a, 4b), mechanically and / or thermally and / or chemically is formed deformable.
    [7]
    7. Vorverbundene multilayer film (1) according to one of claims 1 to 6, characterized in that the at least one cover layer (4) at least partially, preferably substantially completely, consists of a bioresorbable collagen material.
    [8]
    A precoated multilayer film according to claim 7, characterized in that the bioresorbable collagen material comprises type I collagen and / or type III collagen.
    [9]
    9. Pre-bonded multilayer film (1) according to any one of claims 1 to 8, characterized in that the mold layer (3) at least partially, preferably substantially completely, consists of a bioresorbable polymer material.
    [10]
    10. Pre-bonded multilayer film (1) according to claim 9, characterized in that the bioresorbable polymer material comprises lactic acid, preferably L-lactic acid, and / or derivatives thereof.
    [11]
    11. Pre-bonded multilayer film (1) according to claim 9, characterized in that the proportion of lactic acid in the bioresorbable polymer material is at least 70%, preferably about 80% to 95%, particularly preferably substantially 82%.
    [12]
    12. Pre-bonded multilayer film (1) according to any one of claims 9 to 11, characterized in that the bioresorbable polymer material comprises glycolic acid.
    [13]
    13. Pre-bonded multilayer film (1) according to claim 12, characterized in that the proportion of glycolic acid in the bioresorbable polymer material is at most 30%, preferably about 15% to 20%, particularly preferably substantially about 18%.
    [14]
    14. Pre-bonded multilayer film (1) according to one of claims 1 to 13, characterized in that the mold layer (3) and the at least one cover layer (4) have different area expansions.
    [15]
    15. Pre-bonded multilayer film (1) according to claim 14, characterized in that the shaping layer (3) occupies a smaller surface area than the at least one covering layer (4).
    [16]
    16. Pre-bonded multilayer film {1) according to any one of claims 1 to 15, characterized in that the at least one cover layer (4) and / or the mold layer (3) is substantially continuous surface formed or are.
    [17]
    17. Pre-bonded multilayer film (1) according to one of claims 1 to 16, characterized in that the forming layer (3) for forming on the bone defect site (2) has a mold structure (5).
    [18]
    18. Pre-bonded multilayer film (1) according to claim 17, characterized in that the mold structure (5) at least partially a convex and / or concave curved edge (6) and / or at least partially has a convex and / or concave curved shape.
    [19]
    19. Pre-bonded multilayer film (1) according to claim 17 or 18, characterized in that the mold structure (5) has at least one strippenförmiges Anformelement (7).
    [20]
    20. Pre-bonded multilayer film (1) according to any one of claims 17 to 19, characterized in that the mold structure (5) is formed substantially lattice-shaped.
    [21]
    21. Pre-bonded multilayer film (1) according to any one of claims 17 to 20, characterized in that the mold structure (5) by at least one reinforcement of the mold layer (3) is formed.
    [22]
    22. Pre-bonded multilayer film according to one of claims 1 to 21, characterized in that the film (1) has a carrier layer (8) for at least one substance to be arranged or arranged thereon. Innsbruck, on February 5, 2014
    类似技术:
    公开号 | 公开日 | 专利标题
    EP3134026B1|2018-06-27|Dental implant system
    EP0758872B1|1999-05-06|Covering system for defective points in bones and process for producing it
    DE102010055431B4|2014-09-11|Distraction device for bone regeneration in the jaw area
    EP1673030B1|2008-04-09|Planar mesh implant for supplying hernia
    EP2062548B1|2016-05-04|Medicinal membrane for bone regeneration
    DE102010055432A1|2012-06-14|Improved distraction membrane
    DE102013100529A1|2014-07-24|Anchoring element and method of manufacture
    WO2016112894A1|2016-07-21|Method for producing an attachment piece of a cover device for a bone defect site, and device for covering and/or reconstructing a bone defect site
    EP3177232B1|2019-09-04|Method for producing a multilayer film
    EP3102153B1|2018-11-07|Pre-bonded multilayer film for covering a bone defect site
    WO2016180397A1|2016-11-17|Device for covering and/or reconstructing a bone defect site, method for producing a cap for a cover for a bone defect site
    EP3294222A1|2018-03-21|Device for covering and/or reconstructing a bone defect site, method for producing a cap for a cover for a bone defect site
    DE102015108848A1|2016-12-08|Method for producing an orthodontic correction device
    DE102010023794B4|2016-07-21|Medical, in particular dental substrate
    WO1998019621A1|1998-05-14|Stratified material for support parts for dental prosthesis, support parts and method for the production of a support part
    EP2614792A2|2013-07-17|Medical membrane, in particular dental membrane and dental implant with such a membrane
    DE102015102597A1|2016-08-25|Implant for covering bone defects in the jaw area and method for its production
    DE102019116244A1|2020-12-17|Dental implant and set
    DE4232511A1|1994-03-31|Simple screw root system - is for implanting artificial tooth in narrow-section part of lower jaw-bone and incorporates plate for covering hole in bone
    DE19721192A1|1998-12-03|Biocompatible barrier membrane
    同族专利:
    公开号 | 公开日
    HUE041601T2|2019-05-28|
    WO2015117170A1|2015-08-13|
    AT515384B1|2016-04-15|
    EP3102153A1|2016-12-14|
    CN106029008A|2016-10-12|
    PL3102153T3|2019-05-31|
    ES2710474T3|2019-04-25|
    US20160338836A1|2016-11-24|
    EP3102153B1|2018-11-07|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    EP0637452A1|1993-08-06|1995-02-08|Yasuhiko Shimizu|Collagen membrane material for medical use and process for preparing the same|
    DE4414675C1|1994-04-27|1995-09-28|Kirsch Axel|Covering device for bone defects and method for their production|
    WO1997032616A1|1996-03-04|1997-09-12|Axel Kirsch|Covering membrane, moulded bodies produced therefrom and process for the production thereof|
    DE102010055432A1|2010-12-10|2012-06-14|Celgen Ag|Improved distraction membrane|
    FI80605C|1986-11-03|1990-07-10|Biocon Oy|Bone surgical biocomposite material|
    US5700479A|1988-12-23|1997-12-23|Guidor Ab|Surgical element and method for selective tissue regeneration|
    US5372503A|1993-04-27|1994-12-13|Dental Marketing Specialists, Inc.|Method for installation of a dental implant|
    US5380328A|1993-08-09|1995-01-10|Timesh, Inc.|Composite perforated implant structures|
    US6350284B1|1998-09-14|2002-02-26|Bionx Implants, Oy|Bioabsorbable, layered composite material for guided bone tissue regeneration|
    US6328765B1|1998-12-03|2001-12-11|Gore Enterprise Holdings, Inc.|Methods and articles for regenerating living tissue|
    ES2325792T3|2000-05-29|2009-09-17|Celgen Ag|MEDICAL MEMBRANES FOR THE OSEA REGENERATION.|
    US6692498B1|2000-11-27|2004-02-17|Linvatec Corporation|Bioabsorbable, osteopromoting fixation plate|
    US6852330B2|2000-12-21|2005-02-08|Depuy Mitek, Inc.|Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration|
    EP2308423A1|2003-04-16|2011-04-13|Howmedica Osteonics Corp.|Craniofacial implant|
    FI120333B|2003-08-20|2009-09-30|Bioretec Oy|A porous medical device and a method of making it|
    TWI374036B|2004-06-10|2012-10-11|Sean Kerr|Flexible bone composite|
    JP2006124347A|2004-10-29|2006-05-18|Bayer Cropscience Ag|New method for producing phenyl 2-pyrimidinyl ketones and new intermediate therefor|
    US8518123B2|2005-09-09|2013-08-27|Board Of Trustees Of The University Of Arkansas|System and method for tissue generation and bone regeneration|
    US7833253B2|2006-01-17|2010-11-16|Biodynamics Llc|Craniotomy closures and plugs|
    CN1830492B|2006-03-20|2011-05-18|首都医科大学附属北京天坛医院|Bioprotein artificial meninges sheet|
    US8524265B2|2006-08-17|2013-09-03|Warsaw Orthopedic, Inc.|Medical implant sheets useful for tissue regeneration|
    WO2008057344A2|2006-11-06|2008-05-15|Atrium Medical Corporation|Coated surgical mesh|
    WO2010096824A1|2009-02-23|2010-08-26|Bartee Barry K|Reinforced ptfe medical barrier|
    EP2269663B1|2009-07-03|2018-03-07|Armbruster Biotechnology GmbH|Bone graft and biocomposite|
    JP2011212209A|2010-03-31|2011-10-27|Japan Medical Materials Corp|Support for guided bone regeneration|
    TWM435257U|2012-04-27|2012-08-11|Shih-Cheng Wen|Composite regeneration membrane|
    CN202682096U|2012-05-17|2013-01-23|天津市康尔医疗器械有限公司|Absorbable endocranium repair patch|
    DE102012024206A1|2012-12-05|2014-06-18|Celgen Ag|Multi-layered membrane for bone defects|
    US20150245911A1|2013-03-01|2015-09-03|Shih-Liang Stanley Yang|Reinforced multi-layered membrane|
    US20150366669A1|2014-06-24|2015-12-24|Osteogenics Biomedical, Inc.|Perforated membrane for guided bone and tissue regeneration|US10321979B2|2017-10-04|2019-06-18|Dietmar SONNLEITNER|Dental implant system|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA84/2014A|AT515384B1|2014-02-05|2014-02-05|Preconnected multilayer film for covering a bone defect site|ATA84/2014A| AT515384B1|2014-02-05|2014-02-05|Preconnected multilayer film for covering a bone defect site|
    EP15713366.1A| EP3102153B1|2014-02-05|2015-02-03|Pre-bonded multilayer film for covering a bone defect site|
    PL15713366T| PL3102153T3|2014-02-05|2015-02-03|Pre-bonded multilayer film for covering a bone defect site|
    HUE15713366A| HUE041601T2|2014-02-05|2015-02-03|Pre-bonded multilayer film for covering a bone defect site|
    ES15713366T| ES2710474T3|2014-02-05|2015-02-03|Multilayer film to cover a defective place in the bones|
    CN201580010337.3A| CN106029008A|2014-02-05|2015-02-03|preliminarily bonded multilayer film for covering a bone defect site|
    PCT/AT2015/000015| WO2015117170A1|2014-02-05|2015-02-03|Preliminarily bonded multilayer film for covering a bone defect site|
    US15/227,384| US20160338836A1|2014-02-05|2016-08-03|Preliminarily bonded multilayer film for covering a bone defect site|
    [返回顶部]